questions for pAE compute

[kdnghw]

Hello! I have recently read your article "Atomically accurate de novo design of single-domain antibodies" and am very interested in it. In this article, there is a computational metric called pAE (predicted Aligned Error). In my studies, pAE refers to the alignment error between each pair of residues. If I calculate pAE for a segment of the sequence (for example, the CDR3 region), the result should be in the form of a matrix that stores the pAE between each pair of residues. How do you integrate the pAE of each pair of residues into a single value? And how is the criterion of pAE being less than 10 derived?

If you can clarify my doubts, I would be very grateful!