The SpatialDatasets package contains a collection of spatially-resolved omics datasets, which have been formatted into the SpatialExperiment, MoleculeExperiment or CytoImageList Bioconductor classes, for use in examples, demonstrations, and tutorials. The datasets are from several different platforms including IMC, MIBI-TOF, Xenium, CosMx and MERFISH. They have been sourced from various publicly available sources.