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<!DOCTYPE html>
<html lang="en">
<head>
<meta charset="utf-8">
<title>Adsorption and Advanced Materials</title>
<meta content="width=device-width, initial-scale=1.0" name="viewport">
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<li><a href="index.html">Home</a></li>
<li><a href="news.html">News</a></li>
<li class="menu-has-children"><a href="people.html">People</a>
<ul>
<li><a href="david.html">David Fairen-Jimenez</a></li>
<li><a href="students.html">Current Students</a></li>
<li><a href="pdra.html">PDRAs</a></li>
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<ul>
<li><a href="synthesis.html">MOF Engineering</a></li>
<li><a href="adsorption.html">Gas Adsorption and Storage</a></li>
<li><a href="drug.html">Drug Delivery</a></li>
<li><a href="simulations.html">Computational Simulations</a></li>
<li><a href="workwithus.html">Work With Us</a></li>
</ul>
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<!-- About -->
<section class="about" id="about">
<div class="container text-center">
<h2>Drug Delivery</h2>
<div class="container text-justify">
<p>Although there have been great advances in cancer treatment, where survival rates have doubled in the last 40 years,
cancer remains a key health concern. This is especially true for hard-to-treat cancers such as mesothelioma where very
little improvement has been obtained in decades. A main challenge is the development of better drugs, including treatments
based on macromolecules capable of interfere the cell signalling system such as RNAs and inhibitor peptides.
These macromolecules are potentially the most powerful cancer drugs that exist, but still there is no feasible way of
getting them delivered to the tumour, and therefore require a drug delivery system.
<br></br>
A new line of research from our lab has been the development of computational tools (<i>J. Mat. Chem. B</i> <b>2013</b>) to understand this
process, and the design of functional materials based on amorphous MOFs for drug delivery (<i>Chem. Commun.</i> <b>2015</b>, <i>J. Am. Chem. Soc.</i> <b>2017</b>).
We have advanced in creating materials with outstanding loading capacities, extended drug-release times, and grafted functionalities
to improve their performance (<i>Adv. Health. Mat.</i> <b>2016</b>, <i>Chem</i> <b>2017</b>, <i>ACS. Appl. Mat. Interfaces</i> <b>2017</b>).
We are working in the understanding of how the external surface of the MOF affects the endocytosis routes of these materials.
All this has opened new future directions using MOFs as drug delivery vehicles.
</p>
</div>
</div>
</section>
<!-- Slected publications, news styke -->
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<h2>Selected Publications</h2>
<!--paper 1 -->
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<p>
<a href="https://pubs.acs.org/doi/full/10.1021/jacs.7b01451">
Temperature Treatment of Highly Porous Zirconium-Containing Metal–Organic Frameworks Extends Drug Delivery Release
</a>
<br />
Michelle H. Teplensky, Marcus Fantham, Peng Li, Timothy C. Wang, Joshua P. Mehta, Laurence J. Young, Peyman Z. Moghadam, Joseph T. Hupp, Omar K. Farha, Clemens F. Kaminski, David Fairen-Jimenez,
<em>J. Am. Chem. Soc.</em>, <strong>2017</strong>, 139 (22), pp 7522–7532.
</p>
</div>
</div>
<br></br>
<!--paper 2-->
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<p>
<a href="https://onlinelibrary.wiley.com/doi/full/10.1002/adhm.201600296">
Endocytosis Mechanism of Nano Metal‐Organic Frameworks for Drug Delivery
</a>
<br />
Claudia Orellana‐Tavra, Sergio A. Mercado, David Fairen‐Jimenez,
<em>Adv. Healthcare. Mater.</em>, <strong>2016</strong>, 5, pp 2261–2270.
</p>
</div>
</div>
<br></br>
<!--paper 3-->
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<img alt="" class="team-img" src="img/bio paper 3.gif">
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<p>
<a href="https://pubs.rsc.org/en/content/articlehtml/2015/cc/c5cc05237h">
Amorphous metal–organic frameworks for drug delivery
</a>
<br />
Claudia Orellana-Tavra, Emma F. Baxter, Tian Tian, Thomas D. Bennett, Nigel K. H. Slater, Anthony K. Cheetham, David Fairen-Jimenez,
<em>Chem. Comm.</em>, <strong>2015</strong>, 51, pp 13878–13881.
</p>
</div>
</div>
<br></br>
<!--paper 4-->
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<div class="col-sm-9 col-xs-12 text-justify">
<p>
<a href="https://pubs.rsc.org/en/content/articlehtml/2014/tb/c3tb21328e">
Screening of bio-compatible metal–organic frameworks as potential drug carriers using Monte Carlo simulations
</a>
<br />
María C. Bernini, David Fairen-Jimenez, Marcelo Pasinetti, Antonio J. Ramirez-Pastor， Randall Q. Snurr,
<em>J. Mater. Chem. B</em>, <strong>2014</strong>, 2, pp 766-774.
</p>
</div>
</div>
<br></br>
<!--paper 5-->
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<div class="card card-block">
<img alt="" class="team-img" src="img/bio paper 5.gif">
</div>
</div>
<div class="col-sm-9 col-xs-12 text-justify">
<p>
<a href="https://pubs.acs.org/doi/abs/10.1021/acsami.7b17756">
Mechanistic Investigation into the Selective Anticancer Cytotoxicity and Immune System Response of Surface-Functionalized, Dichloroacetate-Loaded, UiO-66 Nanoparticles
</a>
<br />
Isabel Abánades Lázaro, Salame Haddad, José M. Rodrigo-Muñoz, Claudia Orellana-Tavra, Victoria del Pozo, David Fairen-Jimenez, Ross S. Forgan,
<em>ACS Appl. Mater. Interfaces</em>, <strong>2018</strong>, 10 (6), pp 5255-5268.
</p>
</div>
</div>
<br></br>
<!--paper 7-->
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</div>
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<p>
<a href="https://www.sciencedirect.com/science/article/pii/S2451929417300748">
Selective Surface PEGylation of UiO-66 Nanoparticles for Enhanced Stability, Cell Uptake, and pH-Responsive Drug Delivery
</a>
<br />
Isabel Abánades Lázaro, Salame Haddad, Sabrina Sacca, Claudia Orellana-Tavra, David Fairen-Jimenez, Ross S.Forgan,
<em>Chem.</em>, <strong>2017</strong>, 2 (4), pp 561-578.
</p>
</div>
</div>
<br></br>
<!--paper 6-->
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<div class="col-sm-3 col-xs-6">
<div class="card card-block">
<img alt="" class="team-img" src="img/bio paper 6.gif">
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<div class="col-sm-9 col-xs-12 text-justify">
<p>
<a href="https://pubs.acs.org/doi/abs/10.1021/acsami.7b07342">
Tuning the Endocytosis Mechanism of Zr-Based Metal–Organic Frameworks through Linker Functionalization
</a>
<br />
Claudia Orellana-Tavra, Salame Haddad, Ross J. Marshall, Isabel Abánades Lázaro, Gerard Boix, Inhar Imaz, Daniel Maspoch,
Ross S. Forgan, David Fairen-Jimenez,
<em>ACS Appl. Mater. Interfaces</em>, <strong>2017</strong>, 9 (41), pp 35516-35525.
</p>
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