diff --git a/Cargo.lock b/Cargo.lock
index 2479456482..9420f19770 100644
--- a/Cargo.lock
+++ b/Cargo.lock
@@ -1995,6 +1995,7 @@ version = "0.30.1"
 source = "registry+https://github.com/rust-lang/crates.io-index"
 checksum = "2e99fb7a497b1e3339bc746195567ed8d3e24945ecd636e3619d20b9de9e9149"
 dependencies = [
+ "bindgen",
  "cc",
  "pkg-config",
  "vcpkg",
diff --git a/sqlx-macros-core/src/database/mod.rs b/sqlx-macros-core/src/database/mod.rs
index a2d0a1fa0d..50ef911495 100644
--- a/sqlx-macros-core/src/database/mod.rs
+++ b/sqlx-macros-core/src/database/mod.rs
@@ -54,7 +54,27 @@ impl<DB: DatabaseExt> CachingDescribeBlocking<DB> {
             let conn = match cache.entry(database_url.to_string()) {
                 hash_map::Entry::Occupied(hit) => hit.into_mut(),
                 hash_map::Entry::Vacant(miss) => {
-                    miss.insert(DB::Connection::connect(database_url).await?)
+                    let conn = miss.insert(DB::Connection::connect(database_url).await?);
+
+                    #[cfg(feature = "postgres")]
+                    if DB::NAME == sqlx_postgres::Postgres::NAME {
+                        conn.execute(
+                            "
+                            DO $$
+                            BEGIN
+                                IF EXISTS (
+                                    SELECT 1
+                                    FROM pg_settings
+                                    WHERE name = 'plan_cache_mode'
+                                ) THEN
+                                    SET SESSION plan_cache_mode = 'force_generic_plan';
+                                END IF;
+                            END $$;
+                        ",
+                        )
+                        .await?;
+                    }
+                    conn
                 }
             };