From 6e69c2a6ebabbb137b0ff16ee91af42bc77ef626 Mon Sep 17 00:00:00 2001 From: jessexknight Date: Mon, 1 Nov 2021 21:52:39 -0400 Subject: [PATCH] docs/api: revise methods for gee glm, part of #1 & #2 --- docs/api/methods.tex | 11 +++++++---- 1 file changed, 7 insertions(+), 4 deletions(-) diff --git a/docs/api/methods.tex b/docs/api/methods.tex index 079e6ff..20c1b7c 100644 --- a/docs/api/methods.tex +++ b/docs/api/methods.tex @@ -161,9 +161,12 @@ \subsubsection{ART Prevention Impact} relative reduction in incidence and/or proportion of infections averted relative to the base-case scenario for available time horizons relative to \tx{0}. \par -Finally, for each factor of heterogeneity, +For each factor of heterogeneity, we compared projected ART impacts (incidence reduction/infections averted) across different factor levels (whether or not, and how the factor was modelled). -We plotted the impacts versus time since \tx{0}, stratified by factor levels, -and explored whether projected impacts were the same under all factor levels, -testing for significant differences using a Kruskal-Wallis test. +We estimated the effect of each factor level on ART impacts +using linear multivariate regression, with generalized estimating equations \cite{Hojsgaard2006} +to control for clustering due to multiple estimates per study. +Time since \tx{0} was included as a covariate, and two variables were removed due to missingness. +No variable selection was used to avoid biasing effect estimates \cite{Harrell2001}. +We also plotted impacts versus time since \tx{0}, stratified by factor levels. \ No newline at end of file