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DESCRIPTION
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Package: Tapestry
Type: Package
Title: Software for deconvoluting unphased polyclonal genotypes
Version: 0.1.0
Authors@R: as.person(c(
"Jason Hendry <[email protected]> [aut, cre]",
"Bob Verity <[email protected]> [aut]"
))
Description: Malaria infections often contain multiple genotypes, and when
sequenced together these produce a complex signal that is a mixture of the
individual genotypes. Building on the framework of earlier programs like
DEploid and DEploidIBD, Tapestry attempts to pull these individual genotypes
apart by exploiting allele frequency imbalances within a sample, while
simultaneously estimating segments of identity by descent (IBD) between
sequences. Unlike previous programs, Tapestry uses advanced MCMC methods to
ensure that results are robust even for high complexity of infection (COI).
License: MIT + file LICENSE
Encoding: UTF-8
SystemRequirements: C++17
BugReports: https://github.com/mrc-ide/tapestry/issues