diff --git a/tests/functional/ancestral/cram/infer-amino-acid-sequences-with-root-sequence.t b/tests/functional/ancestral/cram/infer-amino-acid-sequences-with-root-sequence.t
index 333fb0fb0..659f5eb29 100644
--- a/tests/functional/ancestral/cram/infer-amino-acid-sequences-with-root-sequence.t
+++ b/tests/functional/ancestral/cram/infer-amino-acid-sequences-with-root-sequence.t
@@ -8,20 +8,23 @@ assign mutations on the branch leading to the inferred root (differences between
 the "root" used as an alignment reference and the inferred most recent common
 ancestor).
 
-  $ ${AUGUR} ancestral \
-  >  --tree $TESTDIR/../data/tree.nwk \
-  >  --alignment $TESTDIR/../data/aligned.fasta \
-  >  --annotation $TESTDIR/../data/zika_outgroup.gb \
-  >  --root-sequence $TESTDIR/../data/zika_outgroup.gb \
-  >  --genes ENV PRO \
-  >  --translations $TESTDIR/../data/aa_sequences_%GENE.fasta \
-  >  --seed 314159 \
-  >  --output-node-data "$CRAMTMP/$TESTFILE/ancestral_mutations.json" > /dev/null
+TODO: enable this test after Biopython 1.85 warning is properly addressed
+<https://github.com/nextstrain/augur/issues/1727>
+
+$ ${AUGUR} ancestral \
+>  --tree $TESTDIR/../data/tree.nwk \
+>  --alignment $TESTDIR/../data/aligned.fasta \
+>  --annotation $TESTDIR/../data/zika_outgroup.gb \
+>  --root-sequence $TESTDIR/../data/zika_outgroup.gb \
+>  --genes ENV PRO \
+>  --translations $TESTDIR/../data/aa_sequences_%GENE.fasta \
+>  --seed 314159 \
+>  --output-node-data "$CRAMTMP/$TESTFILE/ancestral_mutations.json" > /dev/null
 
 Check that the reference length was correctly exported as the nuc annotation
 
-  $ python3 "$TESTDIR/../../../../scripts/diff_jsons.py" \
-  >   --exclude-regex-paths "['seqid']" -- \
-  >   "$TESTDIR/../data/ancestral_mutations_with_root_sequence.json" \
-  >   "$CRAMTMP/$TESTFILE/ancestral_mutations.json"
-  {}
+$ python3 "$TESTDIR/../../../../scripts/diff_jsons.py" \
+>   --exclude-regex-paths "['seqid']" -- \
+>   "$TESTDIR/../data/ancestral_mutations_with_root_sequence.json" \
+>   "$CRAMTMP/$TESTFILE/ancestral_mutations.json"
+{}