From edc1f8069d34977ea06443ba98313bd314d70f13 Mon Sep 17 00:00:00 2001 From: Charles Tapley Hoyt Date: Fri, 19 Jul 2019 21:06:48 -0400 Subject: [PATCH 01/19] Create .gitignore --- .gitignore | 1 + 1 file changed, 1 insertion(+) create mode 100644 .gitignore diff --git a/.gitignore b/.gitignore new file mode 100644 index 000000000..485dee64b --- /dev/null +++ b/.gitignore @@ -0,0 +1 @@ +.idea From 7f8186c747b9751783a7524b60df18e26a2fc8ba Mon Sep 17 00:00:00 2001 From: Charles Tapley Hoyt Date: Sun, 21 Jul 2019 16:35:46 +0200 Subject: [PATCH 02/19] Add descriptions file --- README.md | 4 ++++ descriptions.tsv | 1 + 2 files changed, 5 insertions(+) create mode 100644 descriptions.tsv diff --git a/README.md b/README.md index 93996b60c..15939d8d4 100644 --- a/README.md +++ b/README.md @@ -31,6 +31,10 @@ the FamPlex namespace. * ```entities.csv```. A registry of the families and complexes defined in the FamPlex namespace. + +* ```descriptions.tsv```. Descriptions and citations of some entities. Contains + three columns: the FamPlex name, comma separated reference CURIEs, and a + textual description. * ```grounding_map.csv```. Explicit mapping of text strings to identifiers in biological databases. diff --git a/descriptions.tsv b/descriptions.tsv new file mode 100644 index 000000000..87a2b290c --- /dev/null +++ b/descriptions.tsv @@ -0,0 +1 @@ +CBF3 interpro:IPR016072 SKP1 (together with SKP2) was identified as an essential component of the cyclin A-CDK2 S phase kinase complex From 6e2cd0c48dce9ef260ef2e0efb14941f0bbf1226 Mon Sep 17 00:00:00 2001 From: Charles Tapley Hoyt Date: Sun, 21 Jul 2019 17:09:17 +0200 Subject: [PATCH 03/19] Add upgrade script and rewrite exporters - This adds identifiers and descriptions to all entities. - For now, the old files will stay until there's a good reason to commit to this new format. - TODO: The check_references.py script needs to be rewritten still for the new format --- .gitignore | 101 +- export/famplex.belns | 4 +- export/famplex.obo | 7994 ++++++++-------- export/obo.py | 153 - export/relations_graph.pdf | Bin 0 -> 647387 bytes export/relations_graph.py | 43 - famplex/__init__.py | 3 + famplex/constants.py | 16 + famplex/export/__init__.py | 3 + famplex/export/__main__.py | 8 + famplex/export/cli.py | 22 + .../export/export_belns.py | 26 +- famplex/export/export_obo.py | 227 + famplex/export/export_relations_graph.py | 48 + famplex/reorganize_old_resources.py | 175 + famplex/resources/entities.tsv | 505 + famplex/resources/equivalences.tsv | 1582 +++ famplex/resources/famplex.obo | 8520 +++++++++++++++++ famplex/resources/grounding_map.tsv | 2838 ++++++ famplex/resources/metadata.json | 710 ++ famplex/resources/relations.tsv | 2784 ++++++ famplex/resources/relations_graph.pdf | Bin 0 -> 647384 bytes 22 files changed, 21564 insertions(+), 4198 deletions(-) delete mode 100644 export/obo.py create mode 100644 export/relations_graph.pdf delete mode 100644 export/relations_graph.py create mode 100644 famplex/__init__.py create mode 100644 famplex/constants.py create mode 100644 famplex/export/__init__.py create mode 100644 famplex/export/__main__.py create mode 100644 famplex/export/cli.py rename export/belns.py => famplex/export/export_belns.py (67%) create mode 100644 famplex/export/export_obo.py create mode 100644 famplex/export/export_relations_graph.py create mode 100644 famplex/reorganize_old_resources.py create mode 100644 famplex/resources/entities.tsv create mode 100644 famplex/resources/equivalences.tsv create mode 100644 famplex/resources/famplex.obo create mode 100644 famplex/resources/grounding_map.tsv create mode 100644 famplex/resources/metadata.json create mode 100644 famplex/resources/relations.tsv create mode 100644 famplex/resources/relations_graph.pdf diff --git a/.gitignore b/.gitignore index 485dee64b..cffd6de52 100644 --- a/.gitignore +++ b/.gitignore @@ -1 +1,100 @@ -.idea +# Byte-compiled / optimized / DLL files +__pycache__/ +*.py[cod] +*$py.class + +# C extensions +*.so + +# Distribution / packaging +.Python +env/ +build/ +develop-eggs/ +dist/ +downloads/ +eggs/ +.eggs/ +lib/ +lib64/ +parts/ +sdist/ +var/ +*.egg-info/ +.installed.cfg +*.egg + +# PyInstaller +# Usually these files are written by a python script from a template +# before PyInstaller builds the exe, so as to inject date/other infos into it. +*.manifest +*.spec + +# Installer logs +pip-log.txt +pip-delete-this-directory.txt + +# Unit test / coverage reports +htmlcov/ +.tox/ +.coverage +.coverage.* +.cache +nosetests.xml +coverage.xml +*,cover +.hypothesis/ + +# Translations +*.mo +*.pot + +# Django stuff: +*.log +local_settings.py + +# Flask stuff: +instance/ +.webassets-cache + +# Scrapy stuff: +.scrapy + +# Sphinx documentation +docs/_build/ + +# PyBuilder +target/ + +# IPython Notebook +.ipynb_checkpoints + +# pyenv +.python-version + +# celery beat schedule file +celerybeat-schedule + +# dotenv +.env + +# virtualenv +venv/ +ENV/ + +# Spyder project settings +.spyderproject + +# Rope project settings +.ropeproject + +# PyCharm project settings +.idea/* + +*.pickle +*.gpickle + +scratch +scratch/* + +.pytest_cache diff --git a/export/famplex.belns b/export/famplex.belns index 4d18c7c15..7acb328e5 100644 --- a/export/famplex.belns +++ b/export/famplex.belns @@ -2,8 +2,8 @@ Keyword=FPLX NameString=FamPlex DomainString=Gene and Gene Products -VersionString=20190714 -CreatedDateTime=2019-07-14T13:17:44 +VersionString=20190721 +CreatedDateTime=2019-07-21T16:59:55 DescriptionString=FamPlex is a collection of resources for grounding biological entities from text and describing their hierarchical relationships. QueryValueURL=http://identifiers.org/fplx/ [Author] diff --git a/export/famplex.obo b/export/famplex.obo index 8a87d7777..cf086d6e2 100644 --- a/export/famplex.obo +++ b/export/famplex.obo @@ -1,40 +1,59 @@ format-version: 1.2 -date: 14:07:2019 13:17 +date: 21:07:2019 17:01 + +[Typedef] +id: part_of +name: part of +namespace: external +xref: BFO:0000050 +is_transitive: true + +[Typedef] +id: inverse_is_a +name: inverse is_a + +[Typedef] +id: has_part +name: has part + +[Term] +id: FPLX:000000 +name: famplex [Term] -id: FPLX:9_1_1 +id: FPLX:000001 name: 9-1-1 synonym: "(9-1-1) complex" EXACT [] synonym: "9-1-1 complex" EXACT [] synonym: "9-1-1" EXACT [] synonym: "h9-1-1 complex" EXACT [] xref: BEL:"9-1-1 Complex" -is_a: FPLX:root -has_part: HGNC:HUS1 -has_part: HGNC:RAD1 -has_part: HGNC:RAD9A +is_a: FPLX:000000 ! famplex +relationship: has_part HGNC:5309 ! HUS1 +relationship: has_part HGNC:9806 ! RAD1 +relationship: has_part HGNC:9827 ! RAD9A [Term] -id: FPLX:A4GALT_family +id: FPLX:000002 name: A4GALT-family -is_a: FPLX:Glycosyltransferase -inverse_is_a: HGNC:A4GALT -inverse_is_a: HGNC:A4GNT +is_a: FPLX:000198 ! Glycosyltransferase +relationship: inverse_is_a HGNC:18149 ! A4GALT +relationship: inverse_is_a HGNC:17968 ! A4GNT [Term] -id: FPLX:ABL_family +id: FPLX:000003 name: ABL-family synonym: "ABL family" EXACT [] synonym: "ABL" EXACT [] xref: IP:IPR015015 xref: MEDSCAN:urn:agi-aopfc:0000567 xref: RE:R-HSA-376002 -is_a: FPLX:root -inverse_is_a: HGNC:ABL1 -inverse_is_a: HGNC:ABL2 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:76 ! ABL1 +relationship: inverse_is_a HGNC:77 ! ABL2 [Term] -id: FPLX:ACAD +id: FPLX:000004 name: ACAD synonym: "ACAD" EXACT [] synonym: "acyl CoA dehydrogenase" EXACT [] @@ -42,21 +61,21 @@ synonym: "acyl-CoA dehydrogenase" EXACT [] xref: BEL:"ACAD Family" xref: ECCODE:1.3.8.7 xref: NEXTPROT-FAMILY:00093 -is_a: FPLX:root -inverse_is_a: HGNC:ACAD8 -inverse_is_a: HGNC:ACAD9 -inverse_is_a: HGNC:ACADL -inverse_is_a: HGNC:ACADM -inverse_is_a: HGNC:ACADS -inverse_is_a: HGNC:ACADVL -inverse_is_a: HGNC:ACAD10 -inverse_is_a: HGNC:ACAD11 -inverse_is_a: HGNC:ACADSB -inverse_is_a: HGNC:GCDH -inverse_is_a: HGNC:IVD - -[Term] -id: FPLX:ACC +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:87 ! ACAD8 +relationship: inverse_is_a HGNC:21497 ! ACAD9 +relationship: inverse_is_a HGNC:88 ! ACADL +relationship: inverse_is_a HGNC:89 ! ACADM +relationship: inverse_is_a HGNC:90 ! ACADS +relationship: inverse_is_a HGNC:92 ! ACADVL +relationship: inverse_is_a HGNC:21597 ! ACAD10 +relationship: inverse_is_a HGNC:30211 ! ACAD11 +relationship: inverse_is_a HGNC:91 ! ACADSB +relationship: inverse_is_a HGNC:4189 ! GCDH +relationship: inverse_is_a HGNC:6186 ! IVD + +[Term] +id: FPLX:000005 name: ACC synonym: "ACC" EXACT [] synonym: "ACCs" EXACT [] @@ -67,12 +86,12 @@ xref: BEL:"Acetyl CoA Carboxylase Complex" xref: ECCODE:6.4.1.2 xref: IP:IPR013537 xref: RE:R-HSA-200563 -is_a: FPLX:root -has_part: HGNC:ACACA -has_part: HGNC:ACACB +is_a: FPLX:000000 ! famplex +relationship: has_part HGNC:84 ! ACACA +relationship: has_part HGNC:85 ! ACACB [Term] -id: FPLX:Acetyl_CoA_synthetase +id: FPLX:000006 name: Acetyl-CoA-synthetase synonym: "Acetate-CoA ligase" EXACT [] synonym: "acetyl CoA ligase" EXACT [] @@ -82,43 +101,43 @@ synonym: "acetyl-CoA synthetase" EXACT [] synonym: "acetyl-coenzyme A synthase" EXACT [] synonym: "ACS" EXACT [] xref: BEL:"Acetyl-CoA Synthetase Family" -is_a: FPLX:root -inverse_is_a: HGNC:SLC27A2 -inverse_is_a: HGNC:ACSL1 -inverse_is_a: HGNC:ACSL3 -inverse_is_a: HGNC:ACSL4 -inverse_is_a: HGNC:ACSL5 -inverse_is_a: HGNC:ACSL6 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:10996 ! SLC27A2 +relationship: inverse_is_a HGNC:3569 ! ACSL1 +relationship: inverse_is_a HGNC:3570 ! ACSL3 +relationship: inverse_is_a HGNC:3571 ! ACSL4 +relationship: inverse_is_a HGNC:16526 ! ACSL5 +relationship: inverse_is_a HGNC:16496 ! ACSL6 [Term] -id: FPLX:ACOX +id: FPLX:000007 name: ACOX synonym: "Acyl-CoA Oxidase" EXACT [] synonym: "acyl-CoA oxidases" EXACT [] xref: BEL:"ACOX Family" xref: IP:IPR002655 xref: XFAM:PF01756 -is_a: FPLX:root -inverse_is_a: HGNC:ACOX1 -inverse_is_a: HGNC:ACOX2 -inverse_is_a: HGNC:ACOX3 -inverse_is_a: HGNC:ACOXL +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:119 ! ACOX1 +relationship: inverse_is_a HGNC:120 ! ACOX2 +relationship: inverse_is_a HGNC:121 ! ACOX3 +relationship: inverse_is_a HGNC:25621 ! ACOXL [Term] -id: FPLX:ACSL +id: FPLX:000008 name: ACSL synonym: "Acsl" EXACT [] synonym: "long-chain acyl-CoA synthetase" EXACT [] xref: BEL:"ACSL Family" -is_a: FPLX:root -inverse_is_a: HGNC:ACSL1 -inverse_is_a: HGNC:ACSL3 -inverse_is_a: HGNC:ACSL4 -inverse_is_a: HGNC:ACSL5 -inverse_is_a: HGNC:ACSL6 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:3569 ! ACSL1 +relationship: inverse_is_a HGNC:3570 ! ACSL3 +relationship: inverse_is_a HGNC:3571 ! ACSL4 +relationship: inverse_is_a HGNC:16526 ! ACSL5 +relationship: inverse_is_a HGNC:16496 ! ACSL6 [Term] -id: FPLX:Actin +id: FPLX:000009 name: Actin synonym: "actin filament" EXACT [] synonym: "actin" EXACT [] @@ -131,17 +150,17 @@ xref: MESH:D000199 xref: NCIT:C16258 xref: NEXTPROT-FAMILY:00078 xref: XFAM:PF00022 -is_a: FPLX:root -inverse_is_a: HGNC:ACTA1 -inverse_is_a: HGNC:ACTA2 -inverse_is_a: HGNC:ACTB -inverse_is_a: HGNC:ACTC1 -inverse_is_a: HGNC:ACTG1 -inverse_is_a: HGNC:ACTG2 -inverse_is_a: FPLX:F_actin +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:129 ! ACTA1 +relationship: inverse_is_a HGNC:130 ! ACTA2 +relationship: inverse_is_a HGNC:132 ! ACTB +relationship: inverse_is_a HGNC:143 ! ACTC1 +relationship: inverse_is_a HGNC:144 ! ACTG1 +relationship: inverse_is_a HGNC:145 ! ACTG2 +relationship: inverse_is_a FPLX:000178 ! F_actin [Term] -id: FPLX:Activin +id: FPLX:000010 name: Activin synonym: "activin protein" EXACT [] synonym: "Activin" EXACT [] @@ -152,13 +171,13 @@ xref: NCIT:C20456 xref: RE:R-HSA-2470478 xref: RE:R-HSA-2470491 xref: RE:R-HSA-2470494 -is_a: FPLX:root -inverse_is_a: FPLX:Activin_A -inverse_is_a: FPLX:Activin_AB -inverse_is_a: FPLX:Activin_B +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a FPLX:000011 ! Activin_A +relationship: inverse_is_a FPLX:000012 ! Activin_AB +relationship: inverse_is_a FPLX:000013 ! Activin_B [Term] -id: FPLX:Activin_A +id: FPLX:000011 name: Activin-A synonym: "Activin A protein" EXACT [] synonym: "Activin A" EXACT [] @@ -168,44 +187,44 @@ synonym: "activinA" EXACT [] xref: GO:0043509 xref: IP:IPR000491 xref: RE:R-HSA-206893 -is_a: FPLX:Activin -has_part: HGNC:INHBA +is_a: FPLX:000010 ! Activin +relationship: has_part HGNC:6066 ! INHBA [Term] -id: FPLX:Activin_AB +id: FPLX:000012 name: Activin-AB synonym: "activin AB" EXACT [] xref: RE:R-HSA-1449698 xref: RE:R-HSA-2470478 xref: RE:R-HSA-2470491 xref: RE:R-HSA-2470494 -is_a: FPLX:Activin -has_part: HGNC:INHBA -has_part: HGNC:INHBB +is_a: FPLX:000010 ! Activin +relationship: has_part HGNC:6066 ! INHBA +relationship: has_part HGNC:6067 ! INHBB [Term] -id: FPLX:Activin_B +id: FPLX:000013 name: Activin-B synonym: "activin-B" EXACT [] xref: IP:IPR000381 xref: RE:R-HSA-1449672 -is_a: FPLX:Activin -has_part: HGNC:INHBB +is_a: FPLX:000010 ! Activin +relationship: has_part HGNC:6067 ! INHBB [Term] -id: FPLX:ACTN +id: FPLX:000014 name: ACTN synonym: "actinin" EXACT [] xref: BEL:"ACTN Family" xref: RE:R-HSA-451402 -is_a: FPLX:root -inverse_is_a: HGNC:ACTN1 -inverse_is_a: HGNC:ACTN2 -inverse_is_a: HGNC:ACTN3 -inverse_is_a: HGNC:ACTN4 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:163 ! ACTN1 +relationship: inverse_is_a HGNC:164 ! ACTN2 +relationship: inverse_is_a HGNC:165 ! ACTN3 +relationship: inverse_is_a HGNC:166 ! ACTN4 [Term] -id: FPLX:Adaptor_protein_II +id: FPLX:000015 name: Adaptor-protein-II synonym: "Adaptor Protein 2 complex" EXACT [] synonym: "adaptor protein complex 2" EXACT [] @@ -218,27 +237,27 @@ synonym: "AP2 complex" EXACT [] synonym: "AP2" EXACT [] xref: BEL:"Adaptor Protein II Complex" xref: GO:0030122 -is_a: FPLX:root -has_part: HGNC:AP2B1 -has_part: HGNC:AP2M1 -has_part: HGNC:AP2S1 -has_part: FPLX:AP2A +is_a: FPLX:000000 ! famplex +relationship: has_part HGNC:563 ! AP2B1 +relationship: has_part HGNC:564 ! AP2M1 +relationship: has_part HGNC:565 ! AP2S1 +relationship: has_part FPLX:000049 ! AP2A [Term] -id: FPLX:Adaptor_protein_III +id: FPLX:000016 name: Adaptor-protein-III synonym: "adaptor protein complex 3" EXACT [] synonym: "AP-3" EXACT [] synonym: "AP3" EXACT [] xref: BEL:"Adaptor Protein III Complex" -is_a: FPLX:root -has_part: HGNC:AP3B1 -has_part: HGNC:AP3D1 -has_part: HGNC:AP3S1 -has_part: HGNC:AP3S2 +is_a: FPLX:000000 ! famplex +relationship: has_part HGNC:566 ! AP3B1 +relationship: has_part HGNC:568 ! AP3D1 +relationship: has_part HGNC:2013 ! AP3S1 +relationship: has_part HGNC:571 ! AP3S2 [Term] -id: FPLX:ADCY +id: FPLX:000017 name: ADCY synonym: "adenylate cyclase" EXACT [] synonym: "adenylyl cyclase" EXACT [] @@ -246,38 +265,38 @@ xref: BEL:"ADCY Family" xref: NCIT:C16264 xref: RE:R-HSA-5610577 xref: RE:R-HSA-5610578 -is_a: FPLX:root -inverse_is_a: HGNC:ADCY1 -inverse_is_a: HGNC:ADCY2 -inverse_is_a: HGNC:ADCY3 -inverse_is_a: HGNC:ADCY4 -inverse_is_a: HGNC:ADCY5 -inverse_is_a: HGNC:ADCY6 -inverse_is_a: HGNC:ADCY7 -inverse_is_a: HGNC:ADCY8 -inverse_is_a: HGNC:ADCY9 -inverse_is_a: HGNC:ADCY10 - -[Term] -id: FPLX:ADH +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:232 ! ADCY1 +relationship: inverse_is_a HGNC:233 ! ADCY2 +relationship: inverse_is_a HGNC:234 ! ADCY3 +relationship: inverse_is_a HGNC:235 ! ADCY4 +relationship: inverse_is_a HGNC:236 ! ADCY5 +relationship: inverse_is_a HGNC:237 ! ADCY6 +relationship: inverse_is_a HGNC:238 ! ADCY7 +relationship: inverse_is_a HGNC:239 ! ADCY8 +relationship: inverse_is_a HGNC:240 ! ADCY9 +relationship: inverse_is_a HGNC:21285 ! ADCY10 + +[Term] +id: FPLX:000018 name: ADH synonym: "alcohol dehydrogenase" EXACT [] xref: BEL:"ADH Family" xref: ECCODE:1.1.1.1 xref: NCIT:C16272 xref: XFAM:PF00465 -is_a: FPLX:root -inverse_is_a: HGNC:ADH1A -inverse_is_a: HGNC:ADH1B -inverse_is_a: HGNC:ADH1C -inverse_is_a: HGNC:ADH4 -inverse_is_a: HGNC:ADH5 -inverse_is_a: HGNC:ADH6 -inverse_is_a: HGNC:ADH7 -inverse_is_a: HGNC:ADHFE1 - -[Term] -id: FPLX:ADRA +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:249 ! ADH1A +relationship: inverse_is_a HGNC:250 ! ADH1B +relationship: inverse_is_a HGNC:251 ! ADH1C +relationship: inverse_is_a HGNC:252 ! ADH4 +relationship: inverse_is_a HGNC:253 ! ADH5 +relationship: inverse_is_a HGNC:255 ! ADH6 +relationship: inverse_is_a HGNC:256 ! ADH7 +relationship: inverse_is_a HGNC:16354 ! ADHFE1 + +[Term] +id: FPLX:000019 name: ADRA synonym: "a-adrenoreceptor" EXACT [] synonym: "alpha adrenoceptor" EXACT [] @@ -291,16 +310,16 @@ synonym: "α-adrenoreceptors" EXACT [] xref: BEL:"ADRA Family" xref: GO:0004936 xref: GO:0004937 -is_a: FPLX:root -inverse_is_a: HGNC:ADRA1A -inverse_is_a: HGNC:ADRA1B -inverse_is_a: HGNC:ADRA1D -inverse_is_a: HGNC:ADRA2A -inverse_is_a: HGNC:ADRA2B -inverse_is_a: HGNC:ADRA2C +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:277 ! ADRA1A +relationship: inverse_is_a HGNC:278 ! ADRA1B +relationship: inverse_is_a HGNC:280 ! ADRA1D +relationship: inverse_is_a HGNC:281 ! ADRA2A +relationship: inverse_is_a HGNC:282 ! ADRA2B +relationship: inverse_is_a HGNC:283 ! ADRA2C [Term] -id: FPLX:ADRA2 +id: FPLX:000020 name: ADRA2 synonym: "alpha(2)-adrenoceptors" EXACT [] synonym: "alpha(2)-ARs" EXACT [] @@ -315,13 +334,13 @@ xref: BEL:"ADRA2 Family" xref: GO:0004938 xref: RE:R-HSA-390664 xref: RE:R-HSA-390700 -is_a: FPLX:root -inverse_is_a: HGNC:ADRA2A -inverse_is_a: HGNC:ADRA2B -inverse_is_a: HGNC:ADRA2C +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:281 ! ADRA2A +relationship: inverse_is_a HGNC:282 ! ADRA2B +relationship: inverse_is_a HGNC:283 ! ADRA2C [Term] -id: FPLX:ADRB +id: FPLX:000021 name: ADRB synonym: "b-adrenergic receptor" EXACT [] synonym: "b-receptors" EXACT [] @@ -335,13 +354,13 @@ xref: BEL:"ADRB Family" xref: NCIT:C17062 xref: RE:R-HSA-390643 xref: RE:R-HSA-390670 -is_a: FPLX:root -inverse_is_a: HGNC:ADRB1 -inverse_is_a: HGNC:ADRB2 -inverse_is_a: HGNC:ADRB3 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:285 ! ADRB1 +relationship: inverse_is_a HGNC:286 ! ADRB2 +relationship: inverse_is_a HGNC:288 ! ADRB3 [Term] -id: FPLX:ADRBK +id: FPLX:000022 name: ADRBK synonym: "BARK" EXACT [] synonym: "beta adrenergic receptor kinase" EXACT [] @@ -350,12 +369,12 @@ synonym: "β adrenergic receptor kinase" EXACT [] synonym: "βARK" EXACT [] xref: BEL:"ADRBK Family" xref: RE:R-HSA-8866229 -is_a: FPLX:GRK -inverse_is_a: HGNC:GRK2 -inverse_is_a: HGNC:GRK3 +is_a: FPLX:000192 ! GRK +relationship: inverse_is_a HGNC:289 ! GRK2 +relationship: inverse_is_a HGNC:290 ! GRK3 [Term] -id: FPLX:AKT +id: FPLX:000023 name: AKT synonym: "AKT family" EXACT [] synonym: "AKT" EXACT [] @@ -376,13 +395,13 @@ xref: RE:R-HSA-2317329 xref: RE:R-HSA-2400006 xref: RE:R-HSA-2400013 xref: SIGNOR:SIGNOR-PF24 -is_a: FPLX:root -inverse_is_a: HGNC:AKT1 -inverse_is_a: HGNC:AKT2 -inverse_is_a: HGNC:AKT3 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:391 ! AKT1 +relationship: inverse_is_a HGNC:392 ! AKT2 +relationship: inverse_is_a HGNC:393 ! AKT3 [Term] -id: FPLX:ALDH +id: FPLX:000024 name: ALDH synonym: "aldehyde dehydrogenase (NAD+)" EXACT [] synonym: "Aldehyde dehydrogenase" EXACT [] @@ -391,20 +410,20 @@ synonym: "ALDH" EXACT [] xref: BEL:"ALDH Family" xref: ECCODE:1.2.1.3 xref: NCIT:C118481 -is_a: FPLX:root -inverse_is_a: HGNC:ALDH1A1 -inverse_is_a: HGNC:ALDH1A2 -inverse_is_a: HGNC:ALDH1A3 -inverse_is_a: HGNC:ALDH2 -inverse_is_a: HGNC:ALDH3A1 -inverse_is_a: HGNC:ALDH3A2 -inverse_is_a: HGNC:ALDH3B1 -inverse_is_a: HGNC:ALDH5A1 -inverse_is_a: HGNC:ALDH7A1 -inverse_is_a: HGNC:ALDH9A1 - -[Term] -id: FPLX:ALDO +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:402 ! ALDH1A1 +relationship: inverse_is_a HGNC:15472 ! ALDH1A2 +relationship: inverse_is_a HGNC:409 ! ALDH1A3 +relationship: inverse_is_a HGNC:404 ! ALDH2 +relationship: inverse_is_a HGNC:405 ! ALDH3A1 +relationship: inverse_is_a HGNC:403 ! ALDH3A2 +relationship: inverse_is_a HGNC:410 ! ALDH3B1 +relationship: inverse_is_a HGNC:408 ! ALDH5A1 +relationship: inverse_is_a HGNC:877 ! ALDH7A1 +relationship: inverse_is_a HGNC:412 ! ALDH9A1 + +[Term] +id: FPLX:000025 name: ALDO synonym: "ALDO" EXACT [] synonym: "fructose-bisphosphate aldolase" EXACT [] @@ -413,54 +432,54 @@ xref: ECCODE:4.1.2.13 xref: IP:IPR000741 xref: IP:IPR029768 xref: RE:R-HSA-179508 -is_a: FPLX:root -inverse_is_a: HGNC:ALDOA -inverse_is_a: HGNC:ALDOB -inverse_is_a: HGNC:ALDOC +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:414 ! ALDOA +relationship: inverse_is_a HGNC:417 ! ALDOB +relationship: inverse_is_a HGNC:418 ! ALDOC [Term] -id: FPLX:ALG10 +id: FPLX:000026 name: ALG10 synonym: "ALG10" EXACT [] synonym: "Alpha-1,2-glucosyltransferase" EXACT [] synonym: "Alpha-1,2-glucosyltransferases" EXACT [] synonym: "alpha-1,2-glucosyltransferase" EXACT [] synonym: "alpha-1,2-glucosyltransferases" EXACT [] -is_a: FPLX:Glycosyltransferase -inverse_is_a: HGNC:ALG10 -inverse_is_a: HGNC:ALG10B +is_a: FPLX:000198 ! Glycosyltransferase +relationship: inverse_is_a HGNC:23162 ! ALG10 +relationship: inverse_is_a HGNC:31088 ! ALG10B [Term] -id: FPLX:ALG1_family +id: FPLX:000027 name: ALG1-family -is_a: FPLX:Glycosyltransferase -inverse_is_a: HGNC:ALG1 -inverse_is_a: HGNC:ALG1L -inverse_is_a: HGNC:ALG1L2 -inverse_is_a: HGNC:ALG2 -inverse_is_a: HGNC:ALG11 -inverse_is_a: HGNC:GLT1D1 -inverse_is_a: HGNC:GTDC1 -inverse_is_a: HGNC:GYS1 -inverse_is_a: HGNC:GYS2 -inverse_is_a: HGNC:PIGA - -[Term] -id: FPLX:ALG3_family +is_a: FPLX:000198 ! Glycosyltransferase +relationship: inverse_is_a HGNC:18294 ! ALG1 +relationship: inverse_is_a HGNC:33721 ! ALG1L +relationship: inverse_is_a HGNC:37258 ! ALG1L2 +relationship: inverse_is_a HGNC:23159 ! ALG2 +relationship: inverse_is_a HGNC:32456 ! ALG11 +relationship: inverse_is_a HGNC:26483 ! GLT1D1 +relationship: inverse_is_a HGNC:20887 ! GTDC1 +relationship: inverse_is_a HGNC:4706 ! GYS1 +relationship: inverse_is_a HGNC:4707 ! GYS2 +relationship: inverse_is_a HGNC:8957 ! PIGA + +[Term] +id: FPLX:000028 name: ALG3-family -is_a: FPLX:Glycosyltransferase -inverse_is_a: HGNC:ALG3 -inverse_is_a: HGNC:ALG9 -inverse_is_a: HGNC:ALG12 -inverse_is_a: HGNC:PIGB -inverse_is_a: HGNC:PIGM -inverse_is_a: HGNC:PIGV -inverse_is_a: HGNC:PIGZ -inverse_is_a: HGNC:POMT1 -inverse_is_a: HGNC:POMT2 - -[Term] -id: FPLX:ALG6_family +is_a: FPLX:000198 ! Glycosyltransferase +relationship: inverse_is_a HGNC:23056 ! ALG3 +relationship: inverse_is_a HGNC:15672 ! ALG9 +relationship: inverse_is_a HGNC:19358 ! ALG12 +relationship: inverse_is_a HGNC:8959 ! PIGB +relationship: inverse_is_a HGNC:18858 ! PIGM +relationship: inverse_is_a HGNC:26031 ! PIGV +relationship: inverse_is_a HGNC:30596 ! PIGZ +relationship: inverse_is_a HGNC:9202 ! POMT1 +relationship: inverse_is_a HGNC:19743 ! POMT2 + +[Term] +id: FPLX:000029 name: ALG6-family synonym: "Alpha-1,3-glucosyltransferase" EXACT [] synonym: "Alpha-1,3-glucosyltransferases" EXACT [] @@ -470,19 +489,19 @@ synonym: "Alpha-1,4-glucosyltransferase" EXACT [] synonym: "Alpha-1,4-glucosyltransferases" EXACT [] synonym: "alpha-1,4-glucosyltransferase" EXACT [] synonym: "alpha-1,4-glucosyltransferases" EXACT [] -is_a: FPLX:Glycosyltransferase -inverse_is_a: HGNC:ALG6 -inverse_is_a: HGNC:ALG8 +is_a: FPLX:000198 ! Glycosyltransferase +relationship: inverse_is_a HGNC:23157 ! ALG6 +relationship: inverse_is_a HGNC:23161 ! ALG8 [Term] -id: FPLX:ALG13_family +id: FPLX:000030 name: ALG13-family -is_a: FPLX:Glycosyltransferase -inverse_is_a: HGNC:ALG13 -inverse_is_a: HGNC:ALG14 +is_a: FPLX:000198 ! Glycosyltransferase +relationship: inverse_is_a HGNC:30881 ! ALG13 +relationship: inverse_is_a HGNC:28287 ! ALG14 [Term] -id: FPLX:AMPK +id: FPLX:000031 name: AMPK synonym: "AMPK" EXACT [] xref: BEL:"AMP Activated Protein Kinase Complex" @@ -494,25 +513,25 @@ xref: RE:R-HSA-380931 xref: RE:R-HSA-380934 xref: RE:R-HSA-380961 xref: RE:R-HSA-6805467 -is_a: FPLX:root -inverse_is_a: FPLX:AMPK_A1B1G1 -inverse_is_a: FPLX:AMPK_A1B1G2 -inverse_is_a: FPLX:AMPK_A1B1G3 -inverse_is_a: FPLX:AMPK_A1B2G1 -inverse_is_a: FPLX:AMPK_A1B2G2 -inverse_is_a: FPLX:AMPK_A1B2G3 -inverse_is_a: FPLX:AMPK_A2B1G1 -inverse_is_a: FPLX:AMPK_A2B1G2 -inverse_is_a: FPLX:AMPK_A2B1G3 -inverse_is_a: FPLX:AMPK_A2B2G1 -inverse_is_a: FPLX:AMPK_A2B2G2 -inverse_is_a: FPLX:AMPK_A2B2G3 -has_part: FPLX:AMPK_alpha -has_part: FPLX:AMPK_beta -has_part: FPLX:AMPK_gamma - -[Term] -id: FPLX:AMPK_A1B1G1 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a FPLX:000032 ! AMPK_A1B1G1 +relationship: inverse_is_a FPLX:000033 ! AMPK_A1B1G2 +relationship: inverse_is_a FPLX:000034 ! AMPK_A1B1G3 +relationship: inverse_is_a FPLX:000035 ! AMPK_A1B2G1 +relationship: inverse_is_a FPLX:000036 ! AMPK_A1B2G2 +relationship: inverse_is_a FPLX:000037 ! AMPK_A1B2G3 +relationship: inverse_is_a FPLX:000038 ! AMPK_A2B1G1 +relationship: inverse_is_a FPLX:000039 ! AMPK_A2B1G2 +relationship: inverse_is_a FPLX:000040 ! AMPK_A2B1G3 +relationship: inverse_is_a FPLX:000041 ! AMPK_A2B2G1 +relationship: inverse_is_a FPLX:000042 ! AMPK_A2B2G2 +relationship: inverse_is_a FPLX:000043 ! AMPK_A2B2G3 +relationship: has_part FPLX:000044 ! AMPK_alpha +relationship: has_part FPLX:000045 ! AMPK_beta +relationship: has_part FPLX:000046 ! AMPK_gamma + +[Term] +id: FPLX:000032 name: AMPK-A1B1G1 synonym: "AMPK (alpha 1, beta 1, gamma 1)" EXACT [] synonym: "AMPK (α 1, β 1, γ 1)" EXACT [] @@ -522,13 +541,13 @@ synonym: "AMPK a1b1g1" EXACT [] synonym: "AMPK alpha1beta1gamma1" EXACT [] synonym: "AMPK α1β1γ1" EXACT [] synonym: "α1β1γ1" EXACT [] -is_a: FPLX:AMPK -has_part: HGNC:PRKAA1 -has_part: HGNC:PRKAB1 -has_part: HGNC:PRKAG1 +is_a: FPLX:000031 ! AMPK +relationship: has_part HGNC:9376 ! PRKAA1 +relationship: has_part HGNC:9378 ! PRKAB1 +relationship: has_part HGNC:9385 ! PRKAG1 [Term] -id: FPLX:AMPK_A1B1G2 +id: FPLX:000033 name: AMPK-A1B1G2 synonym: "AMPK (alpha 1, beta 1, gamma 2)" EXACT [] synonym: "AMPK (α 1, β 1, γ 2)" EXACT [] @@ -538,13 +557,13 @@ synonym: "AMPK a1b1g2" EXACT [] synonym: "AMPK alpha1beta1gamma2" EXACT [] synonym: "AMPK α1β1γ2" EXACT [] synonym: "α1β1γ2" EXACT [] -is_a: FPLX:AMPK -has_part: HGNC:PRKAA1 -has_part: HGNC:PRKAB1 -has_part: HGNC:PRKAG2 +is_a: FPLX:000031 ! AMPK +relationship: has_part HGNC:9376 ! PRKAA1 +relationship: has_part HGNC:9378 ! PRKAB1 +relationship: has_part HGNC:9386 ! PRKAG2 [Term] -id: FPLX:AMPK_A1B1G3 +id: FPLX:000034 name: AMPK-A1B1G3 synonym: "AMPK (alpha 1, beta 1, gamma 3)" EXACT [] synonym: "AMPK (α 1, β 1, γ 3)" EXACT [] @@ -554,13 +573,13 @@ synonym: "AMPK a1b1g3" EXACT [] synonym: "AMPK alpha1beta1gamma3" EXACT [] synonym: "AMPK α1β1γ3" EXACT [] synonym: "α1β1γ3" EXACT [] -is_a: FPLX:AMPK -has_part: HGNC:PRKAA1 -has_part: HGNC:PRKAB1 -has_part: HGNC:PRKAG3 +is_a: FPLX:000031 ! AMPK +relationship: has_part HGNC:9376 ! PRKAA1 +relationship: has_part HGNC:9378 ! PRKAB1 +relationship: has_part HGNC:9387 ! PRKAG3 [Term] -id: FPLX:AMPK_A1B2G1 +id: FPLX:000035 name: AMPK-A1B2G1 synonym: "AMPK (alpha 1, beta 2, gamma 1)" EXACT [] synonym: "AMPK (α 1, β 2, γ 1)" EXACT [] @@ -570,13 +589,13 @@ synonym: "AMPK a1b2g1" EXACT [] synonym: "AMPK alpha1beta2gamma1" EXACT [] synonym: "AMPK α1β2γ1" EXACT [] synonym: "α1β2γ1" EXACT [] -is_a: FPLX:AMPK -has_part: HGNC:PRKAA1 -has_part: HGNC:PRKAB2 -has_part: HGNC:PRKAG1 +is_a: FPLX:000031 ! AMPK +relationship: has_part HGNC:9376 ! PRKAA1 +relationship: has_part HGNC:9379 ! PRKAB2 +relationship: has_part HGNC:9385 ! PRKAG1 [Term] -id: FPLX:AMPK_A1B2G2 +id: FPLX:000036 name: AMPK-A1B2G2 synonym: "AMPK (alpha 1, beta 2, gamma 2)" EXACT [] synonym: "AMPK (α 1, β 2, γ 2)" EXACT [] @@ -586,26 +605,26 @@ synonym: "AMPK a1b2g2" EXACT [] synonym: "AMPK alpha1beta2gamma2" EXACT [] synonym: "AMPK α1β2γ2" EXACT [] synonym: "α1β2γ2" EXACT [] -is_a: FPLX:AMPK -has_part: HGNC:PRKAA1 -has_part: HGNC:PRKAB2 -has_part: HGNC:PRKAG2 +is_a: FPLX:000031 ! AMPK +relationship: has_part HGNC:9376 ! PRKAA1 +relationship: has_part HGNC:9379 ! PRKAB2 +relationship: has_part HGNC:9386 ! PRKAG2 [Term] -id: FPLX:AMPK_A1B2G3 +id: FPLX:000037 name: AMPK-A1B2G3 synonym: "AMPK (alpha 1, beta 2, gamma 3)" EXACT [] synonym: "AMPK (α 1, β 2, γ 3)" EXACT [] synonym: "AMPK (A1/B2/G3)" EXACT [] synonym: "AMPK alpha1beta2gamma3" EXACT [] synonym: "AMPK α1β2γ3" EXACT [] -is_a: FPLX:AMPK -has_part: HGNC:PRKAA1 -has_part: HGNC:PRKAB2 -has_part: HGNC:PRKAG3 +is_a: FPLX:000031 ! AMPK +relationship: has_part HGNC:9376 ! PRKAA1 +relationship: has_part HGNC:9379 ! PRKAB2 +relationship: has_part HGNC:9387 ! PRKAG3 [Term] -id: FPLX:AMPK_A2B1G1 +id: FPLX:000038 name: AMPK-A2B1G1 synonym: "AMPK (alpha 2, beta 1, gamma 1)" EXACT [] synonym: "AMPK (α 2, β 1, γ 1)" EXACT [] @@ -615,39 +634,39 @@ synonym: "AMPK a2b1g1" EXACT [] synonym: "AMPK alpha2beta1gamma1" EXACT [] synonym: "AMPK α2β1γ1" EXACT [] synonym: "α2β1γ1" EXACT [] -is_a: FPLX:AMPK -has_part: HGNC:PRKAA2 -has_part: HGNC:PRKAB1 -has_part: HGNC:PRKAG1 +is_a: FPLX:000031 ! AMPK +relationship: has_part HGNC:9377 ! PRKAA2 +relationship: has_part HGNC:9378 ! PRKAB1 +relationship: has_part HGNC:9385 ! PRKAG1 [Term] -id: FPLX:AMPK_A2B1G2 +id: FPLX:000039 name: AMPK-A2B1G2 synonym: "AMPK (alpha 2, beta 1, gamma 2)" EXACT [] synonym: "AMPK (α 2, β 1, γ 2)" EXACT [] synonym: "AMPK (A2/B1/G2)" EXACT [] synonym: "AMPK alpha2beta1gamma2" EXACT [] synonym: "AMPK α2β1γ2" EXACT [] -is_a: FPLX:AMPK -has_part: HGNC:PRKAA2 -has_part: HGNC:PRKAB1 -has_part: HGNC:PRKAG2 +is_a: FPLX:000031 ! AMPK +relationship: has_part HGNC:9377 ! PRKAA2 +relationship: has_part HGNC:9378 ! PRKAB1 +relationship: has_part HGNC:9386 ! PRKAG2 [Term] -id: FPLX:AMPK_A2B1G3 +id: FPLX:000040 name: AMPK-A2B1G3 synonym: "AMPK (alpha 2, beta 1, gamma 3)" EXACT [] synonym: "AMPK (α 2, β 1, γ 3)" EXACT [] synonym: "AMPK (A2/B1/G3)" EXACT [] synonym: "AMPK alpha2beta1gamma3" EXACT [] synonym: "AMPK α2β1γ3" EXACT [] -is_a: FPLX:AMPK -has_part: HGNC:PRKAA2 -has_part: HGNC:PRKAB1 -has_part: HGNC:PRKAG3 +is_a: FPLX:000031 ! AMPK +relationship: has_part HGNC:9377 ! PRKAA2 +relationship: has_part HGNC:9378 ! PRKAB1 +relationship: has_part HGNC:9387 ! PRKAG3 [Term] -id: FPLX:AMPK_A2B2G1 +id: FPLX:000041 name: AMPK-A2B2G1 synonym: "AMPK (alpha 2, beta 2, gamma 1)" EXACT [] synonym: "AMPK (α 2, β 2, γ 1)" EXACT [] @@ -657,13 +676,13 @@ synonym: "AMPK a2b2g1" EXACT [] synonym: "AMPK alpha2beta2gamma1" EXACT [] synonym: "AMPK α2β2γ1" EXACT [] synonym: "α2β2γ1" EXACT [] -is_a: FPLX:AMPK -has_part: HGNC:PRKAA2 -has_part: HGNC:PRKAB2 -has_part: HGNC:PRKAG1 +is_a: FPLX:000031 ! AMPK +relationship: has_part HGNC:9377 ! PRKAA2 +relationship: has_part HGNC:9379 ! PRKAB2 +relationship: has_part HGNC:9385 ! PRKAG1 [Term] -id: FPLX:AMPK_A2B2G2 +id: FPLX:000042 name: AMPK-A2B2G2 synonym: "AMPK (alpha 2, beta 2, gamma 2)" EXACT [] synonym: "AMPK (α 2, β 2, γ 2)" EXACT [] @@ -677,13 +696,13 @@ xref: RE:R-HSA-163679 xref: RE:R-HSA-163736 xref: RE:R-HSA-163747 xref: RE:R-HSA-200408 -is_a: FPLX:AMPK -has_part: HGNC:PRKAA2 -has_part: HGNC:PRKAB2 -has_part: HGNC:PRKAG2 +is_a: FPLX:000031 ! AMPK +relationship: has_part HGNC:9377 ! PRKAA2 +relationship: has_part HGNC:9379 ! PRKAB2 +relationship: has_part HGNC:9386 ! PRKAG2 [Term] -id: FPLX:AMPK_A2B2G3 +id: FPLX:000043 name: AMPK-A2B2G3 synonym: "AMPK (alpha 2, beta 2, gamma 3)" EXACT [] synonym: "AMPK (α 2, β 2, γ 3)" EXACT [] @@ -693,13 +712,13 @@ synonym: "AMPK a2b2g3" EXACT [] synonym: "AMPK alpha2beta2gamma3" EXACT [] synonym: "AMPK α2β2γ3" EXACT [] synonym: "α2β2γ3" EXACT [] -is_a: FPLX:AMPK -has_part: HGNC:PRKAA2 -has_part: HGNC:PRKAB2 -has_part: HGNC:PRKAG3 +is_a: FPLX:000031 ! AMPK +relationship: has_part HGNC:9377 ! PRKAA2 +relationship: has_part HGNC:9379 ! PRKAB2 +relationship: has_part HGNC:9387 ! PRKAG3 [Term] -id: FPLX:AMPK_alpha +id: FPLX:000044 name: AMPK-alpha synonym: "AMPKalpha" EXACT [] synonym: "AMPKα" EXACT [] @@ -711,12 +730,12 @@ xref: RE:R-HSA-2151213 xref: RE:R-HSA-381844 xref: RE:R-HSA-381845 xref: SIGNOR:SIGNOR-PF6 -part_of: FPLX:AMPK -inverse_is_a: HGNC:PRKAA1 -inverse_is_a: HGNC:PRKAA2 +relationship: part_of FPLX:000031 ! AMPK +relationship: inverse_is_a HGNC:9376 ! PRKAA1 +relationship: inverse_is_a HGNC:9377 ! PRKAA2 [Term] -id: FPLX:AMPK_beta +id: FPLX:000045 name: AMPK-beta synonym: "PRKAB" EXACT [] xref: BEL:"PRKAB Family" @@ -724,25 +743,25 @@ xref: IP:IPR006828 xref: IP:IPR032640 xref: RE:R-HSA-2151208 xref: RE:R-HSA-381854 -part_of: FPLX:AMPK -inverse_is_a: HGNC:PRKAB1 -inverse_is_a: HGNC:PRKAB2 +relationship: part_of FPLX:000031 ! AMPK +relationship: inverse_is_a HGNC:9378 ! PRKAB1 +relationship: inverse_is_a HGNC:9379 ! PRKAB2 [Term] -id: FPLX:AMPK_gamma +id: FPLX:000046 name: AMPK-gamma synonym: "PRKAG" EXACT [] xref: BEL:"PRKAG Family" xref: RE:R-HSA-2151212 xref: RE:R-HSA-2316451 xref: RE:R-HSA-381851 -part_of: FPLX:AMPK -inverse_is_a: HGNC:PRKAG1 -inverse_is_a: HGNC:PRKAG2 -inverse_is_a: HGNC:PRKAG3 +relationship: part_of FPLX:000031 ! AMPK +relationship: inverse_is_a HGNC:9385 ! PRKAG1 +relationship: inverse_is_a HGNC:9386 ! PRKAG2 +relationship: inverse_is_a HGNC:9387 ! PRKAG3 [Term] -id: FPLX:Annexin_II_heterotetramer +id: FPLX:000047 name: Annexin-II-heterotetramer synonym: "A2t" EXACT [] synonym: "annexin A2 heterotetramer" EXACT [] @@ -750,55 +769,55 @@ synonym: "annexin II heterotetramer" EXACT [] synonym: "ANXA2 heterotetramer" EXACT [] xref: BEL:"Annexin II Heterotetramer Complex" xref: RE:R-HSA-5336141 -is_a: FPLX:root -has_part: HGNC:ANXA2 -has_part: HGNC:S100A10 +is_a: FPLX:000000 ! famplex +relationship: has_part HGNC:537 ! ANXA2 +relationship: has_part HGNC:10487 ! S100A10 [Term] -id: FPLX:AP1 +id: FPLX:000048 name: AP1 synonym: "AP-1" EXACT [] synonym: "AP1" EXACT [] xref: BEL:"AP-1 Complex" xref: MESH:D018808 xref: NCIT:C17450 -is_a: FPLX:root -has_part: FPLX:FOS_family -has_part: FPLX:JUN_family +is_a: FPLX:000000 ! famplex +relationship: has_part FPLX:000173 ! FOS_family +relationship: has_part FPLX:000268 ! JUN_family [Term] -id: FPLX:AP2A +id: FPLX:000049 name: AP2A xref: IP:IPR017104 -part_of: FPLX:Adaptor_protein_II -inverse_is_a: HGNC:AP2A1 -inverse_is_a: HGNC:AP2A2 +relationship: part_of FPLX:000015 ! Adaptor_protein_II +relationship: inverse_is_a HGNC:561 ! AP2A1 +relationship: inverse_is_a HGNC:562 ! AP2A2 [Term] -id: FPLX:APC_C +id: FPLX:000050 name: APC-C synonym: "APC/C" EXACT [] xref: GO:0005680 xref: MEDSCAN:urn:agi-aopfc:0000571 xref: MEDSCAN:urn:agi-complex:prophash-dd63d0a558770b12c9149b4955828f35 -is_a: FPLX:root -has_part: HGNC:ANAPC2 -has_part: HGNC:ANAPC11 -has_part: HGNC:ANAPC1 -has_part: HGNC:CDC16 -has_part: HGNC:CDC27 -has_part: HGNC:CDC23 -has_part: HGNC:ANAPC5 -has_part: HGNC:ANAPC10 -has_part: HGNC:ANAPC15 -has_part: HGNC:ANAPC13 -has_part: HGNC:CDC26 -has_part: HGNC:ANAPC16 -has_part: HGNC:ANAPC7 -has_part: HGNC:ANAPC4 - -[Term] -id: FPLX:APOA +is_a: FPLX:000000 ! famplex +relationship: has_part HGNC:19989 ! ANAPC2 +relationship: has_part HGNC:14452 ! ANAPC11 +relationship: has_part HGNC:19988 ! ANAPC1 +relationship: has_part HGNC:1720 ! CDC16 +relationship: has_part HGNC:1728 ! CDC27 +relationship: has_part HGNC:1724 ! CDC23 +relationship: has_part HGNC:15713 ! ANAPC5 +relationship: has_part HGNC:24077 ! ANAPC10 +relationship: has_part HGNC:24531 ! ANAPC15 +relationship: has_part HGNC:24540 ! ANAPC13 +relationship: has_part HGNC:17839 ! CDC26 +relationship: has_part HGNC:26976 ! ANAPC16 +relationship: has_part HGNC:17380 ! ANAPC7 +relationship: has_part HGNC:19990 ! ANAPC4 + +[Term] +id: FPLX:000051 name: APOA synonym: "ApoA" EXACT [] synonym: "apoA" EXACT [] @@ -808,14 +827,14 @@ synonym: "apolipoprotein(A)" EXACT [] synonym: "apolipoprotein(a)" EXACT [] xref: BEL:"APOA Family" xref: NCIT:C105952 -is_a: FPLX:Apolipoprotein -inverse_is_a: HGNC:APOA1 -inverse_is_a: HGNC:APOA2 -inverse_is_a: HGNC:APOA4 -inverse_is_a: HGNC:APOA5 +is_a: FPLX:000052 ! Apolipoprotein +relationship: inverse_is_a HGNC:600 ! APOA1 +relationship: inverse_is_a HGNC:601 ! APOA2 +relationship: inverse_is_a HGNC:602 ! APOA4 +relationship: inverse_is_a HGNC:17288 ! APOA5 [Term] -id: FPLX:Apolipoprotein +id: FPLX:000052 name: Apolipoprotein synonym: "Apolipoprotein" EXACT [] synonym: "apolipoprotein" EXACT [] @@ -823,87 +842,87 @@ synonym: "apolipoproteins" EXACT [] xref: IP:IPR000074 xref: MEDSCAN:urn:agi-protfc:apolipoprotein xref: XFAM:PF01442 -is_a: FPLX:root -inverse_is_a: FPLX:APOA -inverse_is_a: HGNC:APOE +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a FPLX:000051 ! APOA +relationship: inverse_is_a HGNC:613 ! APOE [Term] -id: FPLX:ARF_GTPase_family +id: FPLX:000053 name: ARF-GTPase-family synonym: "ADP ribosylation factor" EXACT [] synonym: "ARF" EXACT [] -is_a: FPLX:root -inverse_is_a: HGNC:TRIM23 -inverse_is_a: HGNC:ARF1 -inverse_is_a: HGNC:ARF3 -inverse_is_a: HGNC:ARF4 -inverse_is_a: HGNC:ARF5 -inverse_is_a: HGNC:ARF6 -inverse_is_a: HGNC:ARL1 -inverse_is_a: HGNC:ARL2 -inverse_is_a: HGNC:ARL3 -inverse_is_a: HGNC:ARL4A -inverse_is_a: HGNC:ARL4C -inverse_is_a: HGNC:ARL4D -inverse_is_a: HGNC:ARL5A -inverse_is_a: HGNC:ARL5B -inverse_is_a: HGNC:ARL5C -inverse_is_a: HGNC:ARL6 -inverse_is_a: HGNC:ARL8A -inverse_is_a: HGNC:ARL8B -inverse_is_a: HGNC:ARL9 -inverse_is_a: HGNC:ARL10 -inverse_is_a: HGNC:ARL11 -inverse_is_a: HGNC:ARL13A -inverse_is_a: HGNC:ARL13B -inverse_is_a: HGNC:ARL14 -inverse_is_a: HGNC:ARL15 -inverse_is_a: HGNC:ARL16 -inverse_is_a: HGNC:ARL17A -inverse_is_a: HGNC:ARL17B -inverse_is_a: HGNC:ARFRP1 -inverse_is_a: HGNC:SAR1A -inverse_is_a: HGNC:SAR1B - -[Term] -id: FPLX:Arp2_3_protein +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:660 ! TRIM23 +relationship: inverse_is_a HGNC:652 ! ARF1 +relationship: inverse_is_a HGNC:654 ! ARF3 +relationship: inverse_is_a HGNC:655 ! ARF4 +relationship: inverse_is_a HGNC:658 ! ARF5 +relationship: inverse_is_a HGNC:659 ! ARF6 +relationship: inverse_is_a HGNC:692 ! ARL1 +relationship: inverse_is_a HGNC:693 ! ARL2 +relationship: inverse_is_a HGNC:694 ! ARL3 +relationship: inverse_is_a HGNC:695 ! ARL4A +relationship: inverse_is_a HGNC:698 ! ARL4C +relationship: inverse_is_a HGNC:656 ! ARL4D +relationship: inverse_is_a HGNC:696 ! ARL5A +relationship: inverse_is_a HGNC:23052 ! ARL5B +relationship: inverse_is_a HGNC:31111 ! ARL5C +relationship: inverse_is_a HGNC:13210 ! ARL6 +relationship: inverse_is_a HGNC:25192 ! ARL8A +relationship: inverse_is_a HGNC:25564 ! ARL8B +relationship: inverse_is_a HGNC:23592 ! ARL9 +relationship: inverse_is_a HGNC:22042 ! ARL10 +relationship: inverse_is_a HGNC:24046 ! ARL11 +relationship: inverse_is_a HGNC:31709 ! ARL13A +relationship: inverse_is_a HGNC:25419 ! ARL13B +relationship: inverse_is_a HGNC:22974 ! ARL14 +relationship: inverse_is_a HGNC:25945 ! ARL15 +relationship: inverse_is_a HGNC:27902 ! ARL16 +relationship: inverse_is_a HGNC:24096 ! ARL17A +relationship: inverse_is_a HGNC:32387 ! ARL17B +relationship: inverse_is_a HGNC:662 ! ARFRP1 +relationship: inverse_is_a HGNC:10534 ! SAR1A +relationship: inverse_is_a HGNC:10535 ! SAR1B + +[Term] +id: FPLX:000054 name: Arp2-3-protein synonym: "Arp2/3" EXACT [] xref: BEL:"Arp2/3 Protein Complex" -is_a: FPLX:root -has_part: HGNC:ARPC1A -has_part: HGNC:ARPC1B -has_part: HGNC:ARPC2 -has_part: HGNC:ARPC3 -has_part: HGNC:ARPC4 -has_part: HGNC:ARPC5 -has_part: HGNC:ARPC5L +is_a: FPLX:000000 ! famplex +relationship: has_part HGNC:703 ! ARPC1A +relationship: has_part HGNC:704 ! ARPC1B +relationship: has_part HGNC:705 ! ARPC2 +relationship: has_part HGNC:706 ! ARPC3 +relationship: has_part HGNC:707 ! ARPC4 +relationship: has_part HGNC:708 ! ARPC5 +relationship: has_part HGNC:23366 ! ARPC5L [Term] -id: FPLX:ARRB +id: FPLX:000055 name: ARRB synonym: "b-arrestin" EXACT [] synonym: "barrestins" EXACT [] xref: BEL:"ARRB Family" xref: RE:R-HSA-1911410 -is_a: FPLX:root -inverse_is_a: HGNC:ARRB1 -inverse_is_a: HGNC:ARRB2 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:711 ! ARRB1 +relationship: inverse_is_a HGNC:712 ! ARRB2 [Term] -id: FPLX:ATG4 +id: FPLX:000056 name: ATG4 synonym: "ATG4" EXACT [] synonym: "Atg4" EXACT [] xref: RE:R-HSA-5682664 -is_a: FPLX:root -inverse_is_a: HGNC:ATG4A -inverse_is_a: HGNC:ATG4B -inverse_is_a: HGNC:ATG4C -inverse_is_a: HGNC:ATG4D +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:16489 ! ATG4A +relationship: inverse_is_a HGNC:20790 ! ATG4B +relationship: inverse_is_a HGNC:16040 ! ATG4C +relationship: inverse_is_a HGNC:20789 ! ATG4D [Term] -id: FPLX:ATP1A +id: FPLX:000057 name: ATP1A synonym: "ATP1A" EXACT [] synonym: "ATPase Na+/K+ transporting subunit alpha" EXACT [] @@ -913,64 +932,64 @@ synonym: "ATPase Na+/K+ transporting subunit β" EXACT [] synonym: "Na/K ATPase alpha" EXACT [] synonym: "Na/K ATPase α" EXACT [] xref: RE:R-HSA-936779 -part_of: FPLX:Na_K_ATPase -inverse_is_a: HGNC:ATP1A1 -inverse_is_a: HGNC:ATP1A2 -inverse_is_a: HGNC:ATP1A3 -inverse_is_a: HGNC:ATP1A4 +relationship: part_of FPLX:000303 ! Na_K_ATPase +relationship: inverse_is_a HGNC:799 ! ATP1A1 +relationship: inverse_is_a HGNC:800 ! ATP1A2 +relationship: inverse_is_a HGNC:801 ! ATP1A3 +relationship: inverse_is_a HGNC:14073 ! ATP1A4 [Term] -id: FPLX:ATP1B +id: FPLX:000058 name: ATP1B synonym: "Na,K-ATPase beta subunit" EXACT [] synonym: "Na,K-ATPase β subunit" EXACT [] synonym: "ATP1B" EXACT [] xref: RE:R-HSA-936820 -part_of: FPLX:Na_K_ATPase -inverse_is_a: HGNC:ATP1B1 -inverse_is_a: HGNC:ATP1B2 -inverse_is_a: HGNC:ATP1B3 -inverse_is_a: HGNC:ATP1B4 +relationship: part_of FPLX:000303 ! Na_K_ATPase +relationship: inverse_is_a HGNC:804 ! ATP1B1 +relationship: inverse_is_a HGNC:805 ! ATP1B2 +relationship: inverse_is_a HGNC:806 ! ATP1B3 +relationship: inverse_is_a HGNC:808 ! ATP1B4 [Term] -id: FPLX:ATP5G +id: FPLX:000059 name: ATP5G synonym: "ATP synthase H + transporting mitochondrial F0 complex subunit G" EXACT [] xref: BEL:"ATP5G Family" xref: IP:IPR000454 xref: IP:IPR020537 -part_of: FPLX:ATP_synthase -inverse_is_a: HGNC:ATP5MC1 -inverse_is_a: HGNC:ATP5MC2 -inverse_is_a: HGNC:ATP5MC3 +relationship: part_of FPLX:000060 ! ATP_synthase +relationship: inverse_is_a HGNC:841 ! ATP5MC1 +relationship: inverse_is_a HGNC:842 ! ATP5MC2 +relationship: inverse_is_a HGNC:843 ! ATP5MC3 [Term] -id: FPLX:ATP_synthase +id: FPLX:000060 name: ATP-synthase synonym: "ATP synthase" EXACT [] xref: BEL:"Proton Transporting ATP Synthase Complex" -is_a: FPLX:root -has_part: HGNC:ATP5F1A -has_part: HGNC:ATP5F1B -has_part: HGNC:ATP5F1C -has_part: HGNC:ATP5F1D -has_part: HGNC:ATP5F1E -has_part: HGNC:ATP5MD -has_part: HGNC:ATP5ME -has_part: HGNC:ATP5MF -has_part: HGNC:ATP5MG -has_part: HGNC:ATP5MPL -has_part: HGNC:MT-ATP6 -has_part: HGNC:MT-ATP8 -has_part: HGNC:ATP5PB -has_part: HGNC:ATP5PD -has_part: HGNC:ATP5PF -has_part: HGNC:ATP5PO -has_part: HGNC:ATP5IF1 -has_part: FPLX:ATP5G - -[Term] -id: FPLX:Augmin +is_a: FPLX:000000 ! famplex +relationship: has_part HGNC:823 ! ATP5F1A +relationship: has_part HGNC:830 ! ATP5F1B +relationship: has_part HGNC:833 ! ATP5F1C +relationship: has_part HGNC:837 ! ATP5F1D +relationship: has_part HGNC:838 ! ATP5F1E +relationship: has_part HGNC:30889 ! ATP5MD +relationship: has_part HGNC:846 ! ATP5ME +relationship: has_part HGNC:848 ! ATP5MF +relationship: has_part HGNC:14247 ! ATP5MG +relationship: has_part HGNC:1188 ! ATP5MPL +relationship: has_part HGNC:7414 ! MT-ATP6 +relationship: has_part HGNC:7415 ! MT-ATP8 +relationship: has_part HGNC:840 ! ATP5PB +relationship: has_part HGNC:845 ! ATP5PD +relationship: has_part HGNC:847 ! ATP5PF +relationship: has_part HGNC:850 ! ATP5PO +relationship: has_part HGNC:871 ! ATP5IF1 +relationship: has_part FPLX:000059 ! ATP5G + +[Term] +id: FPLX:000061 name: Augmin synonym: "Augmin" EXACT [] synonym: "HAUS" EXACT [] @@ -978,18 +997,18 @@ synonym: "HAUS complex" EXACT [] xref: GO:0070652 xref: HGNC_GROUP:581 xref: RE:R-HSA-8855211 -is_a: FPLX:root -has_part: HGNC:HAUS1 -has_part: HGNC:HAUS2 -has_part: HGNC:HAUS3 -has_part: HGNC:HAUS4 -has_part: HGNC:HAUS5 -has_part: HGNC:HAUS6 -has_part: HGNC:HAUS7 -has_part: HGNC:HAUS8 - -[Term] -id: FPLX:AXIN +is_a: FPLX:000000 ! famplex +relationship: has_part HGNC:25174 ! HAUS1 +relationship: has_part HGNC:25530 ! HAUS2 +relationship: has_part HGNC:28719 ! HAUS3 +relationship: has_part HGNC:20163 ! HAUS4 +relationship: has_part HGNC:29130 ! HAUS5 +relationship: has_part HGNC:25948 ! HAUS6 +relationship: has_part HGNC:32979 ! HAUS7 +relationship: has_part HGNC:30532 ! HAUS8 + +[Term] +id: FPLX:000062 name: AXIN synonym: "Axin" EXACT [] synonym: "hAxin" EXACT [] @@ -1000,25 +1019,25 @@ xref: RE:R-HSA-3640819 xref: RE:R-HSA-3640863 xref: RE:R-HSA-3772502 xref: RE:R-HSA-4641132 -is_a: FPLX:root -inverse_is_a: HGNC:AXIN1 -inverse_is_a: HGNC:AXIN2 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:903 ! AXIN1 +relationship: inverse_is_a HGNC:904 ! AXIN2 [Term] -id: FPLX:B3GAT +id: FPLX:000063 name: B3GAT synonym: "B3GAT" EXACT [] synonym: "Beta-1,3-glucuronyltransferase" EXACT [] synonym: "Beta-1,3-glucuronyltransferases" EXACT [] synonym: "beta-1,3-glucuronyltransferase" EXACT [] synonym: "beta-1,3-glucuronyltransferases" EXACT [] -is_a: FPLX:Glycosyltransferase -inverse_is_a: HGNC:B3GAT1 -inverse_is_a: HGNC:B3GAT2 -inverse_is_a: HGNC:B3GAT3 +is_a: FPLX:000198 ! Glycosyltransferase +relationship: inverse_is_a HGNC:921 ! B3GAT1 +relationship: inverse_is_a HGNC:922 ! B3GAT2 +relationship: inverse_is_a HGNC:923 ! B3GAT3 [Term] -id: FPLX:BCKDC +id: FPLX:000064 name: BCKDC synonym: "BCKDC" EXACT [] synonym: "BCKDH" EXACT [] @@ -1030,14 +1049,14 @@ xref: BEL:"Branched Chain Alpha Keto Acid Dehydrogenase Complex" xref: RE:R-HSA-5693120 xref: RE:R-HSA-6792583 xref: RE:R-HSA-70019 -is_a: FPLX:root -has_part: HGNC:BCKDHA -has_part: HGNC:BCKDHB -has_part: HGNC:DBT -has_part: HGNC:DLD +is_a: FPLX:000000 ! famplex +relationship: has_part HGNC:986 ! BCKDHA +relationship: has_part HGNC:987 ! BCKDHB +relationship: has_part HGNC:2698 ! DBT +relationship: has_part HGNC:2898 ! DLD [Term] -id: FPLX:Beta_3_4_GTF +id: FPLX:000065 name: Beta-3-4-GTF synonym: "Beta 3-glycosyltransferase" EXACT [] synonym: "Beta 3-glycosyltransferases" EXACT [] @@ -1047,97 +1066,97 @@ synonym: "Beta 4-glycosyltransferase" EXACT [] synonym: "Beta 4-glycosyltransferases" EXACT [] synonym: "beta 4-glycosyltransferase" EXACT [] synonym: "beta 4-glycosyltransferases" EXACT [] -is_a: FPLX:Glycosyltransferase -inverse_is_a: HGNC:B3GALNT1 -inverse_is_a: HGNC:B3GALNT2 -inverse_is_a: HGNC:B3GLCT -inverse_is_a: HGNC:B3GALT1 -inverse_is_a: HGNC:B3GALT2 -inverse_is_a: HGNC:B3GALT4 -inverse_is_a: HGNC:B3GALT5 -inverse_is_a: HGNC:B3GALT6 -inverse_is_a: HGNC:B3GNT2 -inverse_is_a: HGNC:B3GNT3 -inverse_is_a: HGNC:B3GNT4 -inverse_is_a: HGNC:B3GNT5 -inverse_is_a: HGNC:B3GNT6 -inverse_is_a: HGNC:B3GNT7 -inverse_is_a: HGNC:B3GNT8 -inverse_is_a: HGNC:B3GNT9 -inverse_is_a: HGNC:CHPF -inverse_is_a: HGNC:CHPF2 -inverse_is_a: HGNC:CHSY1 -inverse_is_a: HGNC:CHSY3 -inverse_is_a: HGNC:C1GALT1 -inverse_is_a: HGNC:LFNG -inverse_is_a: HGNC:MFNG -inverse_is_a: HGNC:RFNG -inverse_is_a: HGNC:B4GALNT1 -inverse_is_a: HGNC:B4GALNT2 -inverse_is_a: HGNC:B4GALNT3 -inverse_is_a: HGNC:B4GALNT4 -inverse_is_a: HGNC:B4GALT1 -inverse_is_a: HGNC:B4GALT2 -inverse_is_a: HGNC:B4GALT3 -inverse_is_a: HGNC:B4GALT4 -inverse_is_a: HGNC:B4GALT5 -inverse_is_a: HGNC:B4GALT6 -inverse_is_a: HGNC:B4GALT7 -inverse_is_a: HGNC:CSGALNACT1 -inverse_is_a: HGNC:CSGALNACT2 - -[Term] -id: FPLX:BIRC +is_a: FPLX:000198 ! Glycosyltransferase +relationship: inverse_is_a HGNC:918 ! B3GALNT1 +relationship: inverse_is_a HGNC:28596 ! B3GALNT2 +relationship: inverse_is_a HGNC:20207 ! B3GLCT +relationship: inverse_is_a HGNC:916 ! B3GALT1 +relationship: inverse_is_a HGNC:917 ! B3GALT2 +relationship: inverse_is_a HGNC:919 ! B3GALT4 +relationship: inverse_is_a HGNC:920 ! B3GALT5 +relationship: inverse_is_a HGNC:17978 ! B3GALT6 +relationship: inverse_is_a HGNC:15629 ! B3GNT2 +relationship: inverse_is_a HGNC:13528 ! B3GNT3 +relationship: inverse_is_a HGNC:15683 ! B3GNT4 +relationship: inverse_is_a HGNC:15684 ! B3GNT5 +relationship: inverse_is_a HGNC:24141 ! B3GNT6 +relationship: inverse_is_a HGNC:18811 ! B3GNT7 +relationship: inverse_is_a HGNC:24139 ! B3GNT8 +relationship: inverse_is_a HGNC:28714 ! B3GNT9 +relationship: inverse_is_a HGNC:24291 ! CHPF +relationship: inverse_is_a HGNC:29270 ! CHPF2 +relationship: inverse_is_a HGNC:17198 ! CHSY1 +relationship: inverse_is_a HGNC:24293 ! CHSY3 +relationship: inverse_is_a HGNC:24337 ! C1GALT1 +relationship: inverse_is_a HGNC:6560 ! LFNG +relationship: inverse_is_a HGNC:7038 ! MFNG +relationship: inverse_is_a HGNC:9974 ! RFNG +relationship: inverse_is_a HGNC:4117 ! B4GALNT1 +relationship: inverse_is_a HGNC:24136 ! B4GALNT2 +relationship: inverse_is_a HGNC:24137 ! B4GALNT3 +relationship: inverse_is_a HGNC:26315 ! B4GALNT4 +relationship: inverse_is_a HGNC:924 ! B4GALT1 +relationship: inverse_is_a HGNC:925 ! B4GALT2 +relationship: inverse_is_a HGNC:926 ! B4GALT3 +relationship: inverse_is_a HGNC:927 ! B4GALT4 +relationship: inverse_is_a HGNC:928 ! B4GALT5 +relationship: inverse_is_a HGNC:929 ! B4GALT6 +relationship: inverse_is_a HGNC:930 ! B4GALT7 +relationship: inverse_is_a HGNC:24290 ! CSGALNACT1 +relationship: inverse_is_a HGNC:24292 ! CSGALNACT2 + +[Term] +id: FPLX:000066 name: BIRC synonym: "BIRs" EXACT [] xref: BEL:"BIRC Family" xref: IP:IPR001370 -is_a: FPLX:root -inverse_is_a: HGNC:BIRC2 -inverse_is_a: HGNC:BIRC3 -inverse_is_a: HGNC:BIRC5 -inverse_is_a: HGNC:BIRC6 -inverse_is_a: HGNC:BIRC7 -inverse_is_a: HGNC:BIRC8 -inverse_is_a: HGNC:NAIP -inverse_is_a: HGNC:XIAP - -[Term] -id: FPLX:BMP +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:590 ! BIRC2 +relationship: inverse_is_a HGNC:591 ! BIRC3 +relationship: inverse_is_a HGNC:593 ! BIRC5 +relationship: inverse_is_a HGNC:13516 ! BIRC6 +relationship: inverse_is_a HGNC:13702 ! BIRC7 +relationship: inverse_is_a HGNC:14878 ! BIRC8 +relationship: inverse_is_a HGNC:7634 ! NAIP +relationship: inverse_is_a HGNC:592 ! XIAP + +[Term] +id: FPLX:000067 name: BMP synonym: "BMP" EXACT [] xref: BEL:"BMP Family" xref: NCIT:C17274 xref: XFAM:PF02608 -is_a: FPLX:root -inverse_is_a: HGNC:BMP1 -inverse_is_a: HGNC:BMP2 -inverse_is_a: HGNC:BMP3 -inverse_is_a: HGNC:BMP4 -inverse_is_a: HGNC:BMP5 -inverse_is_a: HGNC:BMP6 -inverse_is_a: HGNC:BMP7 -inverse_is_a: HGNC:BMP8A -inverse_is_a: HGNC:BMP8B -inverse_is_a: HGNC:BMP10 -inverse_is_a: HGNC:BMP15 -inverse_is_a: HGNC:GDF1 -inverse_is_a: HGNC:GDF2 -inverse_is_a: HGNC:GDF3 -inverse_is_a: HGNC:GDF5 -inverse_is_a: HGNC:GDF6 -inverse_is_a: HGNC:GDF7 - -[Term] -id: FPLX:BMP_receptor +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:1067 ! BMP1 +relationship: inverse_is_a HGNC:1069 ! BMP2 +relationship: inverse_is_a HGNC:1070 ! BMP3 +relationship: inverse_is_a HGNC:1071 ! BMP4 +relationship: inverse_is_a HGNC:1072 ! BMP5 +relationship: inverse_is_a HGNC:1073 ! BMP6 +relationship: inverse_is_a HGNC:1074 ! BMP7 +relationship: inverse_is_a HGNC:21650 ! BMP8A +relationship: inverse_is_a HGNC:1075 ! BMP8B +relationship: inverse_is_a HGNC:20869 ! BMP10 +relationship: inverse_is_a HGNC:1068 ! BMP15 +relationship: inverse_is_a HGNC:4214 ! GDF1 +relationship: inverse_is_a HGNC:4217 ! GDF2 +relationship: inverse_is_a HGNC:4218 ! GDF3 +relationship: inverse_is_a HGNC:4220 ! GDF5 +relationship: inverse_is_a HGNC:4221 ! GDF6 +relationship: inverse_is_a HGNC:4222 ! GDF7 + +[Term] +id: FPLX:000068 name: BMP-receptor xref: SIGNOR:SIGNOR-PF9 -is_a: FPLX:root -inverse_is_a: FPLX:BMP_receptor_type_I -inverse_is_a: FPLX:BMP_receptor_type_II +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a FPLX:000069 ! BMP_receptor_type_I +relationship: inverse_is_a FPLX:000070 ! BMP_receptor_type_II [Term] -id: FPLX:BMP_receptor_type_I +id: FPLX:000069 name: BMP-receptor-type-I synonym: "BMP Receptor Type I" EXACT [] synonym: "BMP type I receptor" EXACT [] @@ -1148,13 +1167,13 @@ synonym: "bone morphogenetic protein type I receptors" EXACT [] synonym: "BRI" EXACT [] xref: BEL:"BMP Receptor Type I Family" xref: MEDSCAN:urn:agi-protfc:bone%20morphogenetic%20protein%20I%20receptor -is_a: FPLX:BMP_receptor -inverse_is_a: HGNC:ACVR1 -inverse_is_a: HGNC:BMPR1A -inverse_is_a: HGNC:BMPR1B +is_a: FPLX:000068 ! BMP_receptor +relationship: inverse_is_a HGNC:171 ! ACVR1 +relationship: inverse_is_a HGNC:1076 ! BMPR1A +relationship: inverse_is_a HGNC:1077 ! BMPR1B [Term] -id: FPLX:BMP_receptor_type_II +id: FPLX:000070 name: BMP-receptor-type-II synonym: "BMP Receptor Type II" EXACT [] synonym: "BMP type II receptor" EXACT [] @@ -1165,21 +1184,21 @@ synonym: "BRII" EXACT [] xref: BEL:"BMP Receptor Type II Family" xref: RE:R-HSA-201465 xref: RE:R-HSA-201804 -is_a: FPLX:BMP_receptor -inverse_is_a: HGNC:ACVR2A -inverse_is_a: HGNC:ACVR2B -inverse_is_a: HGNC:BMPR2 +is_a: FPLX:000068 ! BMP_receptor +relationship: inverse_is_a HGNC:173 ! ACVR2A +relationship: inverse_is_a HGNC:174 ! ACVR2B +relationship: inverse_is_a HGNC:1078 ! BMPR2 [Term] -id: FPLX:BRCA +id: FPLX:000071 name: BRCA synonym: "BRCA" EXACT [] -is_a: FPLX:root -inverse_is_a: HGNC:BRCA1 -inverse_is_a: HGNC:BRCA2 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:1100 ! BRCA1 +relationship: inverse_is_a HGNC:1101 ! BRCA2 [Term] -id: FPLX:C1 +id: FPLX:000072 name: C1 synonym: "c1 complex" EXACT [] synonym: "C1" EXACT [] @@ -1188,24 +1207,24 @@ xref: BEL:"C1 Complex" xref: RE:R-HSA-173584 xref: RE:R-HSA-173615 xref: RE:R-HSA-173617 -is_a: FPLX:root -has_part: HGNC:C1QA -has_part: HGNC:C1QB -has_part: HGNC:C1QC -has_part: HGNC:C1R -has_part: HGNC:C1S +is_a: FPLX:000000 ! famplex +relationship: has_part HGNC:1241 ! C1QA +relationship: has_part HGNC:1242 ! C1QB +relationship: has_part HGNC:1245 ! C1QC +relationship: has_part HGNC:1246 ! C1R +relationship: has_part HGNC:1247 ! C1S [Term] -id: FPLX:C1q +id: FPLX:000073 name: C1q synonym: "C1q" EXACT [] xref: BEL:"C1q Complex" -is_a: FPLX:root -has_part: HGNC:C1QA -has_part: HGNC:C1QB +is_a: FPLX:000000 ! famplex +relationship: has_part HGNC:1241 ! C1QA +relationship: has_part HGNC:1242 ! C1QB [Term] -id: FPLX:Cadherin +id: FPLX:000074 name: Cadherin synonym: "cadherin" EXACT [] xref: BEL:"CDH Family" @@ -1213,31 +1232,31 @@ xref: MEDSCAN:urn:agi-complex:prophash-8a9e47ee0ee03d8d8b6e029e2fba6896 xref: MEDSCAN:urn:agi-protfc:cadherin xref: NCIT:C16373 xref: XFAM:PF00028 -is_a: FPLX:root -inverse_is_a: HGNC:CDH1 -inverse_is_a: HGNC:CDH10 -inverse_is_a: HGNC:CDH11 -inverse_is_a: HGNC:CDH12 -inverse_is_a: HGNC:CDH13 -inverse_is_a: HGNC:CDH15 -inverse_is_a: HGNC:CDH16 -inverse_is_a: HGNC:CDH17 -inverse_is_a: HGNC:CDH18 -inverse_is_a: HGNC:CDH19 -inverse_is_a: HGNC:CDH2 -inverse_is_a: HGNC:CDH20 -inverse_is_a: HGNC:CDH22 -inverse_is_a: HGNC:CDH24 -inverse_is_a: HGNC:CDH3 -inverse_is_a: HGNC:CDH4 -inverse_is_a: HGNC:CDH5 -inverse_is_a: HGNC:CDH6 -inverse_is_a: HGNC:CDH7 -inverse_is_a: HGNC:CDH8 -inverse_is_a: HGNC:CDH9 - -[Term] -id: FPLX:CALM +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:1748 ! CDH1 +relationship: inverse_is_a HGNC:1749 ! CDH10 +relationship: inverse_is_a HGNC:1750 ! CDH11 +relationship: inverse_is_a HGNC:1751 ! CDH12 +relationship: inverse_is_a HGNC:1753 ! CDH13 +relationship: inverse_is_a HGNC:1754 ! CDH15 +relationship: inverse_is_a HGNC:1755 ! CDH16 +relationship: inverse_is_a HGNC:1756 ! CDH17 +relationship: inverse_is_a HGNC:1757 ! CDH18 +relationship: inverse_is_a HGNC:1758 ! CDH19 +relationship: inverse_is_a HGNC:1759 ! CDH2 +relationship: inverse_is_a HGNC:1760 ! CDH20 +relationship: inverse_is_a HGNC:13251 ! CDH22 +relationship: inverse_is_a HGNC:14265 ! CDH24 +relationship: inverse_is_a HGNC:1762 ! CDH3 +relationship: inverse_is_a HGNC:1763 ! CDH4 +relationship: inverse_is_a HGNC:1764 ! CDH5 +relationship: inverse_is_a HGNC:1765 ! CDH6 +relationship: inverse_is_a HGNC:1766 ! CDH7 +relationship: inverse_is_a HGNC:1767 ! CDH8 +relationship: inverse_is_a HGNC:1768 ! CDH9 + +[Term] +id: FPLX:000075 name: CALM synonym: "Calmodulin" EXACT [] synonym: "calmodulin" EXACT [] @@ -1247,28 +1266,28 @@ xref: MEDSCAN:urn:agi-aopfc:0000452 xref: MEDSCAN:urn:agi-complex:prophash-f7e292d6e30998b81cf5f772ab430f11 xref: NCIT:C16375 xref: NEXTPROT-FAMILY:00440 -is_a: FPLX:root -inverse_is_a: HGNC:CALM1 -inverse_is_a: HGNC:CALM2 -inverse_is_a: HGNC:CALM3 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:1442 ! CALM1 +relationship: inverse_is_a HGNC:1445 ! CALM2 +relationship: inverse_is_a HGNC:1449 ! CALM3 [Term] -id: FPLX:CAMK +id: FPLX:000076 name: CAMK synonym: "CaMK family" EXACT [] synonym: "CaMK" EXACT [] xref: BEL:"CAMK Family" xref: ECCODE:2.7.11.17 xref: NEXTPROT-FAMILY:03072 -is_a: FPLX:root -inverse_is_a: HGNC:CAMK1 -inverse_is_a: HGNC:CAMK1D -inverse_is_a: HGNC:CAMK1G -inverse_is_a: HGNC:CAMK4 -inverse_is_a: FPLX:CAMK2_family +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:1459 ! CAMK1 +relationship: inverse_is_a HGNC:19341 ! CAMK1D +relationship: inverse_is_a HGNC:14585 ! CAMK1G +relationship: inverse_is_a HGNC:1464 ! CAMK4 +relationship: inverse_is_a FPLX:000078 ! CAMK2_family [Term] -id: FPLX:CAMK2_complex +id: FPLX:000077 name: CAMK2-complex synonym: "Ca(2+)-calmodulin-dependent protein kinase II" EXACT [] synonym: "Ca(2+)/calmodulin-dependent kinase II" EXACT [] @@ -1282,14 +1301,14 @@ xref: RE:R-HSA-417004 xref: RE:R-HSA-432792 xref: RE:R-HSA-444796 xref: RE:R-HSA-445374 -is_a: FPLX:root -has_part: HGNC:CAMK2A -has_part: HGNC:CAMK2B -has_part: HGNC:CAMK2D -has_part: HGNC:CAMK2G +is_a: FPLX:000000 ! famplex +relationship: has_part HGNC:1460 ! CAMK2A +relationship: has_part HGNC:1461 ! CAMK2B +relationship: has_part HGNC:1462 ! CAMK2D +relationship: has_part HGNC:1463 ! CAMK2G [Term] -id: FPLX:CAMK2_family +id: FPLX:000078 name: CAMK2-family synonym: "calmodulindependent kinase II" EXACT [] synonym: "CAMK2" EXACT [] @@ -1301,14 +1320,14 @@ xref: RE:R-HSA-417004 xref: RE:R-HSA-432792 xref: RE:R-HSA-444796 xref: RE:R-HSA-445374 -is_a: FPLX:CAMK -inverse_is_a: HGNC:CAMK2A -inverse_is_a: HGNC:CAMK2B -inverse_is_a: HGNC:CAMK2D -inverse_is_a: HGNC:CAMK2G +is_a: FPLX:000076 ! CAMK +relationship: inverse_is_a HGNC:1460 ! CAMK2A +relationship: inverse_is_a HGNC:1461 ! CAMK2B +relationship: inverse_is_a HGNC:1462 ! CAMK2D +relationship: inverse_is_a HGNC:1463 ! CAMK2G [Term] -id: FPLX:CAPN +id: FPLX:000079 name: CAPN synonym: "calpain" EXACT [] xref: BEL:"CAPN Family" @@ -1317,39 +1336,39 @@ xref: IP:IPR022684 xref: NCIT:C16377 xref: RE:R-HSA-8848649 xref: RE:R-HSA-8848668 -is_a: FPLX:root -inverse_is_a: HGNC:CAPN1 -inverse_is_a: HGNC:CAPN10 -inverse_is_a: HGNC:CAPN11 -inverse_is_a: HGNC:CAPN12 -inverse_is_a: HGNC:CAPN13 -inverse_is_a: HGNC:CAPN14 -inverse_is_a: HGNC:CAPN2 -inverse_is_a: HGNC:CAPN3 -inverse_is_a: HGNC:CAPN5 -inverse_is_a: HGNC:CAPN6 -inverse_is_a: HGNC:CAPN7 -inverse_is_a: HGNC:CAPN9 -inverse_is_a: HGNC:CAPN15 -inverse_is_a: HGNC:CAPN8 - -[Term] -id: FPLX:Carboxylesterase +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:1476 ! CAPN1 +relationship: inverse_is_a HGNC:1477 ! CAPN10 +relationship: inverse_is_a HGNC:1478 ! CAPN11 +relationship: inverse_is_a HGNC:13249 ! CAPN12 +relationship: inverse_is_a HGNC:16663 ! CAPN13 +relationship: inverse_is_a HGNC:16664 ! CAPN14 +relationship: inverse_is_a HGNC:1479 ! CAPN2 +relationship: inverse_is_a HGNC:1480 ! CAPN3 +relationship: inverse_is_a HGNC:1482 ! CAPN5 +relationship: inverse_is_a HGNC:1483 ! CAPN6 +relationship: inverse_is_a HGNC:1484 ! CAPN7 +relationship: inverse_is_a HGNC:1486 ! CAPN9 +relationship: inverse_is_a HGNC:11182 ! CAPN15 +relationship: inverse_is_a HGNC:1485 ! CAPN8 + +[Term] +id: FPLX:000080 name: Carboxylesterase synonym: "carboxylesterase" EXACT [] synonym: "carboxylesterases" EXACT [] xref: BEL:"Carboxylesterase Family" xref: ECCODE:3.1.1.1 xref: NCIT:C112051 -is_a: FPLX:root -inverse_is_a: HGNC:CES1 -inverse_is_a: HGNC:CES2 -inverse_is_a: HGNC:CES3 -inverse_is_a: HGNC:CES4A -inverse_is_a: HGNC:CES5A +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:1863 ! CES1 +relationship: inverse_is_a HGNC:1864 ! CES2 +relationship: inverse_is_a HGNC:1865 ! CES3 +relationship: inverse_is_a HGNC:26741 ! CES4A +relationship: inverse_is_a HGNC:26459 ! CES5A [Term] -id: FPLX:Caspase +id: FPLX:000081 name: Caspase synonym: "caspase" EXACT [] synonym: "caspases" EXACT [] @@ -1360,30 +1379,30 @@ xref: IP:IPR033139 xref: MESH:D020169 xref: NCIT:C18153 xref: XFAM:PF00656 -is_a: FPLX:root -inverse_is_a: HGNC:CASP1 -inverse_is_a: HGNC:CASP2 -inverse_is_a: HGNC:CASP4 -inverse_is_a: HGNC:CASP5 -inverse_is_a: HGNC:CASP6 -inverse_is_a: HGNC:CASP8 -inverse_is_a: HGNC:CASP9 -inverse_is_a: HGNC:CASP10 -inverse_is_a: HGNC:CASP12 -inverse_is_a: HGNC:CASP14 -inverse_is_a: FPLX:Caspase_3_7 - -[Term] -id: FPLX:Caspase_3_7 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:1499 ! CASP1 +relationship: inverse_is_a HGNC:1503 ! CASP2 +relationship: inverse_is_a HGNC:1505 ! CASP4 +relationship: inverse_is_a HGNC:1506 ! CASP5 +relationship: inverse_is_a HGNC:1507 ! CASP6 +relationship: inverse_is_a HGNC:1509 ! CASP8 +relationship: inverse_is_a HGNC:1511 ! CASP9 +relationship: inverse_is_a HGNC:1500 ! CASP10 +relationship: inverse_is_a HGNC:19004 ! CASP12 +relationship: inverse_is_a HGNC:1502 ! CASP14 +relationship: inverse_is_a FPLX:000082 ! Caspase_3_7 + +[Term] +id: FPLX:000082 name: Caspase-3-7 synonym: "caspase-3/7" EXACT [] xref: RE:R-HSA-202877 -is_a: FPLX:Caspase -inverse_is_a: HGNC:CASP3 -inverse_is_a: HGNC:CASP7 +is_a: FPLX:000081 ! Caspase +relationship: inverse_is_a HGNC:1504 ! CASP3 +relationship: inverse_is_a HGNC:1508 ! CASP7 [Term] -id: FPLX:CAV +id: FPLX:000083 name: CAV synonym: "Caveolin" EXACT [] synonym: "caveolin" EXACT [] @@ -1393,14 +1412,15 @@ xref: IP:IPR018361 xref: MEDSCAN:urn:agi-protfc:caveolin xref: NEXTPROT-FAMILY:00489 xref: XFAM:PF01146 -is_a: FPLX:root -inverse_is_a: HGNC:CAV1 -inverse_is_a: HGNC:CAV2 -inverse_is_a: HGNC:CAV3 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:1527 ! CAV1 +relationship: inverse_is_a HGNC:1528 ! CAV2 +relationship: inverse_is_a HGNC:1529 ! CAV3 [Term] -id: FPLX:CBF3 +id: FPLX:000084 name: CBF3 +def: "SKP1 (together with SKP2) was identified as an essential component of the cyclin A-CDK2 S phase kinase complex" [interpro:IPR016072] synonym: "CBF3 complex" EXACT [] synonym: "CBF3" EXACT [] synonym: "kinetochore centromere binding factor 3" EXACT [] @@ -1408,11 +1428,11 @@ xref: BEL:"CBF3 Complex" xref: GO:0031518 xref: IP:IPR016072 xref: IP:IPR016897 -is_a: FPLX:root -has_part: HGNC:SKP1 +is_a: FPLX:000000 ! famplex +relationship: has_part HGNC:10899 ! SKP1 [Term] -id: FPLX:CCT_complex +id: FPLX:000085 name: CCT-complex synonym: "CCT complex" EXACT [] synonym: "CCT" EXACT [] @@ -1427,75 +1447,75 @@ xref: IP:IPR002194 xref: MEDSCAN:urn:agi-complex:prophash-cd6413d79122d5489ee4b4e339245b61 xref: RE:R-HSA-390455 xref: RE:R-HSA-390474 -is_a: FPLX:root -has_part: HGNC:CCT2 -has_part: HGNC:CCT3 -has_part: HGNC:CCT4 -has_part: HGNC:CCT5 -has_part: HGNC:CCT6A -has_part: HGNC:CCT6B -has_part: HGNC:CCT7 -has_part: HGNC:CCT8 -has_part: HGNC:TCP1 - -[Term] -id: FPLX:CD16 +is_a: FPLX:000000 ! famplex +relationship: has_part HGNC:1615 ! CCT2 +relationship: has_part HGNC:1616 ! CCT3 +relationship: has_part HGNC:1617 ! CCT4 +relationship: has_part HGNC:1618 ! CCT5 +relationship: has_part HGNC:1620 ! CCT6A +relationship: has_part HGNC:1621 ! CCT6B +relationship: has_part HGNC:1622 ! CCT7 +relationship: has_part HGNC:1623 ! CCT8 +relationship: has_part HGNC:11655 ! TCP1 + +[Term] +id: FPLX:000086 name: CD16 synonym: "CD16" EXACT [] xref: BEL:"CD16 Family" xref: NCIT:C17487 -is_a: FPLX:root -inverse_is_a: HGNC:FCGR3A -inverse_is_a: HGNC:FCGR3B +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:3619 ! FCGR3A +relationship: inverse_is_a HGNC:3620 ! FCGR3B [Term] -id: FPLX:CD3 +id: FPLX:000087 name: CD3 synonym: "CD3" EXACT [] xref: BEL:"CD3 Complex" xref: MEDSCAN:urn:agi-complex:CD3%20complex xref: NCIT:C38897 -is_a: FPLX:root -has_part: HGNC:CD247 -has_part: HGNC:CD3D -has_part: HGNC:CD3E -has_part: HGNC:CD3G +is_a: FPLX:000000 ! famplex +relationship: has_part HGNC:1677 ! CD247 +relationship: has_part HGNC:1673 ! CD3D +relationship: has_part HGNC:1674 ! CD3E +relationship: has_part HGNC:1675 ! CD3G [Term] -id: FPLX:CD32 +id: FPLX:000088 name: CD32 synonym: "CD32" EXACT [] xref: BEL:"CD32 Family" xref: NCIT:C18308 -is_a: FPLX:root -inverse_is_a: HGNC:FCGR2A -inverse_is_a: HGNC:FCGR2B -inverse_is_a: HGNC:FCGR2C +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:3616 ! FCGR2A +relationship: inverse_is_a HGNC:3618 ! FCGR2B +relationship: inverse_is_a HGNC:15626 ! FCGR2C [Term] -id: FPLX:CD64 +id: FPLX:000089 name: CD64 synonym: "CD64" EXACT [] xref: BEL:"CD64 Family" xref: RE:R-HSA-1031694 xref: RE:R-HSA-1236898 xref: RE:R-HSA-1236905 -is_a: FPLX:root -inverse_is_a: HGNC:FCGR1A -inverse_is_a: HGNC:FCGR1B +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:3613 ! FCGR1A +relationship: inverse_is_a HGNC:3614 ! FCGR1B [Term] -id: FPLX:CD8 +id: FPLX:000090 name: CD8 synonym: "CD8" EXACT [] xref: MEDSCAN:urn:agi-complex:CD8 xref: RE:R-HSA-198899 -is_a: FPLX:root -inverse_is_a: HGNC:CD8A -inverse_is_a: HGNC:CD8B +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:1706 ! CD8A +relationship: inverse_is_a HGNC:1707 ! CD8B [Term] -id: FPLX:CDC25 +id: FPLX:000091 name: CDC25 synonym: "CDC25 family" EXACT [] synonym: "Cdc25 phosphatases" EXACT [] @@ -1506,13 +1526,13 @@ xref: IP:IPR000751 xref: MEDSCAN:urn:agi-aopfc:0000551 xref: RE:R-HSA-170108 xref: RE:R-HSA-69261 -is_a: FPLX:root -inverse_is_a: HGNC:CDC25A -inverse_is_a: HGNC:CDC25B -inverse_is_a: HGNC:CDC25C +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:1725 ! CDC25A +relationship: inverse_is_a HGNC:1726 ! CDC25B +relationship: inverse_is_a HGNC:1727 ! CDC25C [Term] -id: FPLX:CDK +id: FPLX:000092 name: CDK synonym: "CDK" EXACT [] synonym: "Cdk" EXACT [] @@ -1521,45 +1541,45 @@ xref: ECCODE:2.7.11.22 xref: MEDSCAN:urn:agi-complex:prophash-4dda466320b1a32b046d823accadbaee xref: MESH:D018844 xref: NCIT:C17767 -is_a: FPLX:root -inverse_is_a: HGNC:CDKL1 -inverse_is_a: HGNC:CDKL2 -inverse_is_a: HGNC:CDKL3 -inverse_is_a: HGNC:CDKL4 -inverse_is_a: HGNC:CDKL5 -inverse_is_a: FPLX:CDK1_2 -inverse_is_a: HGNC:CDK3 -inverse_is_a: HGNC:CDK4 -inverse_is_a: HGNC:CDK5 -inverse_is_a: HGNC:CDK6 -inverse_is_a: HGNC:CDK7 -inverse_is_a: HGNC:CDK8 -inverse_is_a: HGNC:CDK9 -inverse_is_a: HGNC:CDK10 -inverse_is_a: HGNC:CDK11A -inverse_is_a: HGNC:CDK11B -inverse_is_a: HGNC:CDK12 -inverse_is_a: HGNC:CDK13 -inverse_is_a: HGNC:CDK14 -inverse_is_a: HGNC:CDK15 -inverse_is_a: HGNC:CDK16 -inverse_is_a: HGNC:CDK17 -inverse_is_a: HGNC:CDK18 -inverse_is_a: HGNC:CDK19 -inverse_is_a: HGNC:CDK20 - -[Term] -id: FPLX:CDK1_2 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:1781 ! CDKL1 +relationship: inverse_is_a HGNC:1782 ! CDKL2 +relationship: inverse_is_a HGNC:15483 ! CDKL3 +relationship: inverse_is_a HGNC:19287 ! CDKL4 +relationship: inverse_is_a HGNC:11411 ! CDKL5 +relationship: inverse_is_a FPLX:000093 ! CDK1_2 +relationship: inverse_is_a HGNC:1772 ! CDK3 +relationship: inverse_is_a HGNC:1773 ! CDK4 +relationship: inverse_is_a HGNC:1774 ! CDK5 +relationship: inverse_is_a HGNC:1777 ! CDK6 +relationship: inverse_is_a HGNC:1778 ! CDK7 +relationship: inverse_is_a HGNC:1779 ! CDK8 +relationship: inverse_is_a HGNC:1780 ! CDK9 +relationship: inverse_is_a HGNC:1770 ! CDK10 +relationship: inverse_is_a HGNC:1730 ! CDK11A +relationship: inverse_is_a HGNC:1729 ! CDK11B +relationship: inverse_is_a HGNC:24224 ! CDK12 +relationship: inverse_is_a HGNC:1733 ! CDK13 +relationship: inverse_is_a HGNC:8883 ! CDK14 +relationship: inverse_is_a HGNC:14434 ! CDK15 +relationship: inverse_is_a HGNC:8749 ! CDK16 +relationship: inverse_is_a HGNC:8750 ! CDK17 +relationship: inverse_is_a HGNC:8751 ! CDK18 +relationship: inverse_is_a HGNC:19338 ! CDK19 +relationship: inverse_is_a HGNC:21420 ! CDK20 + +[Term] +id: FPLX:000093 name: CDK1-2 synonym: "CDK1/2" EXACT [] synonym: "cdk1/2" EXACT [] synonym: "Cdk1/2" EXACT [] -is_a: FPLX:CDK -inverse_is_a: HGNC:CDK1 -inverse_is_a: HGNC:CDK2 +is_a: FPLX:000092 ! CDK +relationship: inverse_is_a HGNC:1722 ! CDK1 +relationship: inverse_is_a HGNC:1771 ! CDK2 [Term] -id: FPLX:CDKN +id: FPLX:000094 name: CDKN synonym: "CDKN" EXACT [] synonym: "CKI" EXACT [] @@ -1568,100 +1588,100 @@ synonym: "cyclin-dependent kinase inhibitor" EXACT [] synonym: "cyclin-dependent protein kinase inhibitors" EXACT [] xref: NCIT:C18492 xref: XFAM:PF02234 -is_a: FPLX:root -inverse_is_a: FPLX:CDKN1 -inverse_is_a: FPLX:CDKN2 -inverse_is_a: HGNC:CDKN3 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a FPLX:000095 ! CDKN1 +relationship: inverse_is_a FPLX:000096 ! CDKN2 +relationship: inverse_is_a HGNC:1791 ! CDKN3 [Term] -id: FPLX:CDKN1 +id: FPLX:000095 name: CDKN1 synonym: "CDKN1" EXACT [] xref: IP:IPR003175 xref: RE:R-HSA-8941923 xref: RE:R-HSA-8942604 xref: RE:R-HSA-8948131 -is_a: FPLX:CDKN -inverse_is_a: HGNC:CDKN1A -inverse_is_a: HGNC:CDKN1B -inverse_is_a: HGNC:CDKN1C +is_a: FPLX:000094 ! CDKN +relationship: inverse_is_a HGNC:1784 ! CDKN1A +relationship: inverse_is_a HGNC:1785 ! CDKN1B +relationship: inverse_is_a HGNC:1786 ! CDKN1C [Term] -id: FPLX:CDKN2 +id: FPLX:000096 name: CDKN2 synonym: "CDKN2" EXACT [] -is_a: FPLX:CDKN -inverse_is_a: HGNC:CDKN2A -inverse_is_a: HGNC:CDKN2B -inverse_is_a: HGNC:CDKN2C -inverse_is_a: HGNC:CDKN2D +is_a: FPLX:000094 ! CDKN +relationship: inverse_is_a HGNC:1787 ! CDKN2A +relationship: inverse_is_a HGNC:1788 ! CDKN2B +relationship: inverse_is_a HGNC:1789 ! CDKN2C +relationship: inverse_is_a HGNC:1790 ! CDKN2D [Term] -id: FPLX:CEBP +id: FPLX:000097 name: CEBP synonym: "C/EBP" EXACT [] synonym: "CCAAT/enhancer binding protein" EXACT [] xref: BEL:"CEBP Family" xref: NEXTPROT-FAMILY:00406 -is_a: FPLX:root -inverse_is_a: HGNC:CEBPA -inverse_is_a: HGNC:CEBPB -inverse_is_a: HGNC:CEBPD -inverse_is_a: HGNC:CEBPG -inverse_is_a: HGNC:CEBPE +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:1833 ! CEBPA +relationship: inverse_is_a HGNC:1834 ! CEBPB +relationship: inverse_is_a HGNC:1835 ! CEBPD +relationship: inverse_is_a HGNC:1837 ! CEBPG +relationship: inverse_is_a HGNC:1836 ! CEBPE [Term] -id: FPLX:CHEK +id: FPLX:000098 name: CHEK synonym: "checkpoint kinase" EXACT [] synonym: "Chk1/2" EXACT [] xref: MEDSCAN:urn:agi-protfc:checkpoint%20kinase -is_a: FPLX:root -inverse_is_a: HGNC:CHEK1 -inverse_is_a: HGNC:CHEK2 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:1925 ! CHEK1 +relationship: inverse_is_a HGNC:16627 ! CHEK2 [Term] -id: FPLX:Chemokine +id: FPLX:000099 name: Chemokine synonym: "chemokine" EXACT [] synonym: "chemokines" EXACT [] xref: MEDSCAN:urn:agi-aopfc:0000391 xref: NCIT:C20466 -is_a: FPLX:root -inverse_is_a: FPLX:CXCL_ELR_negative -inverse_is_a: FPLX:CXCL_ELR_positive +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a FPLX:000128 ! CXCL_ELR_negative +relationship: inverse_is_a FPLX:000129 ! CXCL_ELR_positive [Term] -id: FPLX:Chemokine_receptor +id: FPLX:000100 name: Chemokine-receptor synonym: "chemoattractant receptor" EXACT [] xref: BEL:"Chemokine Receptor Family" -is_a: FPLX:root -inverse_is_a: HGNC:ACKR2 -inverse_is_a: HGNC:CCR1 -inverse_is_a: HGNC:CCR10 -inverse_is_a: HGNC:CCR2 -inverse_is_a: HGNC:CCR3 -inverse_is_a: HGNC:CCR4 -inverse_is_a: HGNC:CCR5 -inverse_is_a: HGNC:CCR6 -inverse_is_a: HGNC:CCR7 -inverse_is_a: HGNC:CCR8 -inverse_is_a: HGNC:CCR9 -inverse_is_a: HGNC:ACKR4 -inverse_is_a: HGNC:CCRL2 -inverse_is_a: HGNC:CX3CR1 -inverse_is_a: HGNC:CXCR1 -inverse_is_a: HGNC:CXCR2 -inverse_is_a: HGNC:CXCR3 -inverse_is_a: HGNC:CXCR4 -inverse_is_a: HGNC:CXCR5 -inverse_is_a: HGNC:CXCR6 -inverse_is_a: HGNC:ACKR3 -inverse_is_a: HGNC:XCR1 - -[Term] -id: FPLX:Cholinesterase +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:1565 ! ACKR2 +relationship: inverse_is_a HGNC:1602 ! CCR1 +relationship: inverse_is_a HGNC:4474 ! CCR10 +relationship: inverse_is_a HGNC:1603 ! CCR2 +relationship: inverse_is_a HGNC:1604 ! CCR3 +relationship: inverse_is_a HGNC:1605 ! CCR4 +relationship: inverse_is_a HGNC:1606 ! CCR5 +relationship: inverse_is_a HGNC:1607 ! CCR6 +relationship: inverse_is_a HGNC:1608 ! CCR7 +relationship: inverse_is_a HGNC:1609 ! CCR8 +relationship: inverse_is_a HGNC:1610 ! CCR9 +relationship: inverse_is_a HGNC:1611 ! ACKR4 +relationship: inverse_is_a HGNC:1612 ! CCRL2 +relationship: inverse_is_a HGNC:2558 ! CX3CR1 +relationship: inverse_is_a HGNC:6026 ! CXCR1 +relationship: inverse_is_a HGNC:6027 ! CXCR2 +relationship: inverse_is_a HGNC:4540 ! CXCR3 +relationship: inverse_is_a HGNC:2561 ! CXCR4 +relationship: inverse_is_a HGNC:1060 ! CXCR5 +relationship: inverse_is_a HGNC:16647 ! CXCR6 +relationship: inverse_is_a HGNC:23692 ! ACKR3 +relationship: inverse_is_a HGNC:1625 ! XCR1 + +[Term] +id: FPLX:000101 name: Cholinesterase synonym: "choline esterase" EXACT [] synonym: "cholinesterase" EXACT [] @@ -1670,44 +1690,44 @@ xref: IP:IPR000997 xref: IP:IPR014788 xref: RE:R-HSA-2990868 xref: RE:R-HSA-3640837 -is_a: FPLX:root -inverse_is_a: HGNC:ACHE -inverse_is_a: HGNC:BCHE +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:108 ! ACHE +relationship: inverse_is_a HGNC:983 ! BCHE [Term] -id: FPLX:CHRM +id: FPLX:000102 name: CHRM synonym: "acetylcholine receptor" EXACT [] xref: BEL:"CHRM Family" xref: IP:IPR000995 -is_a: FPLX:root -inverse_is_a: HGNC:CHRM1 -inverse_is_a: HGNC:CHRM2 -inverse_is_a: HGNC:CHRM3 -inverse_is_a: HGNC:CHRM4 -inverse_is_a: HGNC:CHRM5 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:1950 ! CHRM1 +relationship: inverse_is_a HGNC:1951 ! CHRM2 +relationship: inverse_is_a HGNC:1952 ! CHRM3 +relationship: inverse_is_a HGNC:1953 ! CHRM4 +relationship: inverse_is_a HGNC:1954 ! CHRM5 [Term] -id: FPLX:CHRN +id: FPLX:000103 name: CHRN synonym: "nAChR" EXACT [] synonym: "nicotine class acetylcholine receptors" EXACT [] synonym: "nicotinic acetylcholine receptor" EXACT [] xref: BEL:"CHRN Complex" xref: GO:0016904 -is_a: FPLX:root -has_part: HGNC:CHRNA2 -has_part: HGNC:CHRNA3 -has_part: HGNC:CHRNA4 -has_part: HGNC:CHRNA5 -has_part: HGNC:CHRNA6 -has_part: HGNC:CHRNA7 -has_part: HGNC:CHRNB2 -has_part: HGNC:CHRNB3 -has_part: HGNC:CHRNB4 - -[Term] -id: FPLX:CK2 +is_a: FPLX:000000 ! famplex +relationship: has_part HGNC:1956 ! CHRNA2 +relationship: has_part HGNC:1957 ! CHRNA3 +relationship: has_part HGNC:1958 ! CHRNA4 +relationship: has_part HGNC:1959 ! CHRNA5 +relationship: has_part HGNC:15963 ! CHRNA6 +relationship: has_part HGNC:1960 ! CHRNA7 +relationship: has_part HGNC:1962 ! CHRNB2 +relationship: has_part HGNC:1963 ! CHRNB3 +relationship: has_part HGNC:1964 ! CHRNB4 + +[Term] +id: FPLX:000104 name: CK2 synonym: "casein kinase 2" EXACT [] synonym: "casein kinase II complex" EXACT [] @@ -1719,13 +1739,13 @@ xref: NCIT:C107559 xref: NEXTPROT-FAMILY:03101 xref: RE:R-HSA-201711 xref: RE:R-HSA-6805066 -is_a: FPLX:root -has_part: HGNC:CSNK2A1 -has_part: HGNC:CSNK2A2 -has_part: HGNC:CSNK2B +is_a: FPLX:000000 ! famplex +relationship: has_part HGNC:2457 ! CSNK2A1 +relationship: has_part HGNC:2459 ! CSNK2A2 +relationship: has_part HGNC:2460 ! CSNK2B [Term] -id: FPLX:Clathrin +id: FPLX:000105 name: Clathrin synonym: "clathrin coat" EXACT [] synonym: "clathrin" EXACT [] @@ -1734,33 +1754,33 @@ xref: GO:0016190 xref: RE:R-HSA-5138439 xref: RE:R-HSA-5138447 xref: RE:R-HSA-5333713 -is_a: FPLX:root -has_part: HGNC:CLTA -has_part: HGNC:CLTB -has_part: HGNC:CLTC +is_a: FPLX:000000 ! famplex +relationship: has_part HGNC:2090 ! CLTA +relationship: has_part HGNC:2091 ! CLTB +relationship: has_part HGNC:2092 ! CLTC [Term] -id: FPLX:CNKSR +id: FPLX:000106 name: CNKSR synonym: "CNKSR" EXACT [] synonym: "connector enhancer of kinase suppressor of ras" EXACT [] xref: NEXTPROT-FAMILY:00653 -is_a: FPLX:root -inverse_is_a: HGNC:CNKSR1 -inverse_is_a: HGNC:CNKSR2 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:19700 ! CNKSR1 +relationship: inverse_is_a HGNC:19701 ! CNKSR2 [Term] -id: FPLX:Cofilin +id: FPLX:000107 name: Cofilin synonym: "cofilin" EXACT [] xref: IP:IPR017904 -is_a: FPLX:root -inverse_is_a: HGNC:CFL1 -inverse_is_a: HGNC:CFL2 -inverse_is_a: HGNC:DSTN +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:1874 ! CFL1 +relationship: inverse_is_a HGNC:1875 ! CFL2 +relationship: inverse_is_a HGNC:15750 ! DSTN [Term] -id: FPLX:Cohesin +id: FPLX:000108 name: Cohesin synonym: "cohesin complex" EXACT [] synonym: "cohesin" EXACT [] @@ -1768,12 +1788,12 @@ xref: BEL:"Cohesin Complex" xref: GO:0008278 xref: GO:0008279 xref: XFAM:PF00963 -is_a: FPLX:root -has_part: HGNC:RAD21 -has_part: HGNC:SMC3 +is_a: FPLX:000000 ! famplex +relationship: has_part HGNC:9811 ! RAD21 +relationship: has_part HGNC:2468 ! SMC3 [Term] -id: FPLX:COL1 +id: FPLX:000109 name: COL1 synonym: "collagen type I" EXACT [] synonym: "Type I collagen" EXACT [] @@ -1794,12 +1814,12 @@ xref: RE:R-HSA-2396456 xref: RE:R-HSA-2396478 xref: RE:R-HSA-2399520 xref: RE:R-HSA-2428941 -is_a: FPLX:root -inverse_is_a: HGNC:COL1A1 -inverse_is_a: HGNC:COL1A2 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:2197 ! COL1A1 +relationship: inverse_is_a HGNC:2198 ! COL1A2 [Term] -id: FPLX:COL4 +id: FPLX:000110 name: COL4 synonym: "Col4" EXACT [] synonym: "ColIV" EXACT [] @@ -1811,16 +1831,16 @@ xref: GO:0005587 xref: IP:IPR001442 xref: NCIT:C16448 xref: RE:R-HSA-2127389 -is_a: FPLX:root -inverse_is_a: HGNC:COL4A1 -inverse_is_a: HGNC:COL4A2 -inverse_is_a: HGNC:COL4A3 -inverse_is_a: HGNC:COL4A4 -inverse_is_a: HGNC:COL4A5 -inverse_is_a: HGNC:COL4A6 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:2202 ! COL4A1 +relationship: inverse_is_a HGNC:2203 ! COL4A2 +relationship: inverse_is_a HGNC:2204 ! COL4A3 +relationship: inverse_is_a HGNC:2206 ! COL4A4 +relationship: inverse_is_a HGNC:2207 ! COL4A5 +relationship: inverse_is_a HGNC:2208 ! COL4A6 [Term] -id: FPLX:COL5 +id: FPLX:000111 name: COL5 synonym: "collagen type V" EXACT [] synonym: "type V collagen" EXACT [] @@ -1829,59 +1849,59 @@ xref: BEL:"COL5 Family" xref: GO:0005588 xref: RE:R-HSA-2127310 xref: RE:R-HSA-2127422 -is_a: FPLX:root -inverse_is_a: HGNC:COL5A1 -inverse_is_a: HGNC:COL5A2 -inverse_is_a: HGNC:COL5A3 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:2209 ! COL5A1 +relationship: inverse_is_a HGNC:2210 ! COL5A2 +relationship: inverse_is_a HGNC:14864 ! COL5A3 [Term] -id: FPLX:COLGALT +id: FPLX:000112 name: COLGALT synonym: "COLGALT" EXACT [] synonym: "Collagen beta(1-O)galactosyltransferase" EXACT [] synonym: "Collagen beta(1-O)galactosyltransferases" EXACT [] synonym: "collagen beta(1-O)galactosyltransferase" EXACT [] synonym: "collagen beta(1-O)galactosyltransferases" EXACT [] -is_a: FPLX:Glycosyltransferase -inverse_is_a: HGNC:COLGALT1 -inverse_is_a: HGNC:COLGALT2 +is_a: FPLX:000198 ! Glycosyltransferase +relationship: inverse_is_a HGNC:26182 ! COLGALT1 +relationship: inverse_is_a HGNC:16790 ! COLGALT2 [Term] -id: FPLX:COX +id: FPLX:000113 name: COX synonym: "Complex IV" EXACT [] synonym: "cytochrome c oxidase" EXACT [] xref: BEL:"Cytochrome C Oxidase Complex Muscle" xref: BEL:"Cytochrome C Oxidase Complex Non Muscle" xref: ECCODE:1.9.3.1 -is_a: FPLX:root -has_part: HGNC:COX5A -has_part: HGNC:COX5B -has_part: FPLX:COX4 -has_part: FPLX:COX6A -has_part: FPLX:COX6B -has_part: FPLX:COX7A -has_part: FPLX:COX7B -has_part: FPLX:COX8 -has_part: HGNC:COX10 -has_part: HGNC:COX11 -has_part: HGNC:COX15 -has_part: HGNC:COX17 - -[Term] -id: FPLX:COX4 +is_a: FPLX:000000 ! famplex +relationship: has_part HGNC:2267 ! COX5A +relationship: has_part HGNC:2269 ! COX5B +relationship: has_part FPLX:000114 ! COX4 +relationship: has_part FPLX:000115 ! COX6A +relationship: has_part FPLX:000116 ! COX6B +relationship: has_part FPLX:000117 ! COX7A +relationship: has_part FPLX:000118 ! COX7B +relationship: has_part FPLX:000119 ! COX8 +relationship: has_part HGNC:2260 ! COX10 +relationship: has_part HGNC:2261 ! COX11 +relationship: has_part HGNC:2263 ! COX15 +relationship: has_part HGNC:2264 ! COX17 + +[Term] +id: FPLX:000114 name: COX4 synonym: "Cox4" EXACT [] xref: BEL:"COX4 Family" xref: IP:IPR004203 xref: IP:IPR013288 xref: XFAM:PF02936 -part_of: FPLX:COX -inverse_is_a: HGNC:COX4I1 -inverse_is_a: HGNC:COX4I2 +relationship: part_of FPLX:000113 ! COX +relationship: inverse_is_a HGNC:2265 ! COX4I1 +relationship: inverse_is_a HGNC:16232 ! COX4I2 [Term] -id: FPLX:COX6A +id: FPLX:000115 name: COX6A synonym: "COX6A" EXACT [] synonym: "Cox6a" EXACT [] @@ -1890,77 +1910,77 @@ xref: BEL:"COX6A Family" xref: IP:IPR001349 xref: IP:IPR018507 xref: XFAM:PF02046 -part_of: FPLX:COX -inverse_is_a: HGNC:COX6A1 -inverse_is_a: HGNC:COX6A2 +relationship: part_of FPLX:000113 ! COX +relationship: inverse_is_a HGNC:2277 ! COX6A1 +relationship: inverse_is_a HGNC:2279 ! COX6A2 [Term] -id: FPLX:COX6B +id: FPLX:000116 name: COX6B synonym: "Cox6b" EXACT [] xref: BEL:"COX6B Family" xref: XFAM:PF02297 -part_of: FPLX:COX -inverse_is_a: HGNC:COX6B1 -inverse_is_a: HGNC:COX6B2 +relationship: part_of FPLX:000113 ! COX +relationship: inverse_is_a HGNC:2280 ! COX6B1 +relationship: inverse_is_a HGNC:24380 ! COX6B2 [Term] -id: FPLX:COX7A +id: FPLX:000117 name: COX7A synonym: "COX7A" EXACT [] synonym: "Cox7a" EXACT [] xref: BEL:"COX7A Family" xref: XFAM:PF02238 -part_of: FPLX:COX -inverse_is_a: HGNC:COX7A1 -inverse_is_a: HGNC:COX7A2 +relationship: part_of FPLX:000113 ! COX +relationship: inverse_is_a HGNC:2287 ! COX7A1 +relationship: inverse_is_a HGNC:2288 ! COX7A2 [Term] -id: FPLX:COX7B +id: FPLX:000118 name: COX7B synonym: "Cox7b" EXACT [] xref: BEL:"COX7B Family" xref: IP:IPR008433 xref: IP:IPR023272 xref: XFAM:PF05392 -part_of: FPLX:COX -inverse_is_a: HGNC:COX7B -inverse_is_a: HGNC:COX7B2 +relationship: part_of FPLX:000113 ! COX +relationship: inverse_is_a HGNC:2291 ! COX7B +relationship: inverse_is_a HGNC:24381 ! COX7B2 [Term] -id: FPLX:COX8 +id: FPLX:000119 name: COX8 synonym: "Cox8" EXACT [] synonym: "cytochrome c oxidase subunit VIII" EXACT [] xref: BEL:"COX8 Family" xref: IP:IPR003205 xref: XFAM:PF02285 -part_of: FPLX:COX -inverse_is_a: HGNC:COX8A -inverse_is_a: HGNC:COX8C +relationship: part_of FPLX:000113 ! COX +relationship: inverse_is_a HGNC:2294 ! COX8A +relationship: inverse_is_a HGNC:24382 ! COX8C [Term] -id: FPLX:CREB +id: FPLX:000120 name: CREB synonym: "CREB family" EXACT [] synonym: "CREB" EXACT [] xref: BEL:"CREB Family" xref: MEDSCAN:urn:agi-aopfc:0000094 xref: NCIT:C17286 -is_a: FPLX:root -inverse_is_a: HGNC:CREB1 -inverse_is_a: HGNC:CREB3 -inverse_is_a: HGNC:CREB5 -inverse_is_a: HGNC:CREB3L1 -inverse_is_a: HGNC:CREB3L2 -inverse_is_a: HGNC:CREB3L3 -inverse_is_a: HGNC:CREB3L4 -inverse_is_a: HGNC:CREM -inverse_is_a: HGNC:ATF1 -inverse_is_a: HGNC:ATF2 - -[Term] -id: FPLX:CRISP +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:2345 ! CREB1 +relationship: inverse_is_a HGNC:2347 ! CREB3 +relationship: inverse_is_a HGNC:16844 ! CREB5 +relationship: inverse_is_a HGNC:18856 ! CREB3L1 +relationship: inverse_is_a HGNC:23720 ! CREB3L2 +relationship: inverse_is_a HGNC:18855 ! CREB3L3 +relationship: inverse_is_a HGNC:18854 ! CREB3L4 +relationship: inverse_is_a HGNC:2352 ! CREM +relationship: inverse_is_a HGNC:783 ! ATF1 +relationship: inverse_is_a HGNC:784 ! ATF2 + +[Term] +id: FPLX:000121 name: CRISP synonym: "CRISP" EXACT [] synonym: "CRISPs" EXACT [] @@ -1970,13 +1990,13 @@ xref: BEL:"CRISP Family" xref: IP:IPR013871 xref: IP:IPR034117 xref: XFAM:PF08562 -is_a: FPLX:root -inverse_is_a: HGNC:CRISP1 -inverse_is_a: HGNC:CRISP2 -inverse_is_a: HGNC:CRISP3 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:304 ! CRISP1 +relationship: inverse_is_a HGNC:12024 ! CRISP2 +relationship: inverse_is_a HGNC:16904 ! CRISP3 [Term] -id: FPLX:CRSP +id: FPLX:000122 name: CRSP synonym: "CRSP complex" EXACT [] synonym: "CRSP" EXACT [] @@ -1984,26 +2004,26 @@ synonym: "CRSP/Med complex" EXACT [] synonym: "transcriptional cofactor complex CRSP" EXACT [] xref: BEL:"CRSP Complex" xref: NCIT:C28687 -is_a: FPLX:root -has_part: HGNC:MED1 -has_part: HGNC:MED14 -has_part: HGNC:MED17 -has_part: HGNC:MED23 -has_part: HGNC:MED26 -has_part: HGNC:MED27 -has_part: HGNC:MED7 +is_a: FPLX:000000 ! famplex +relationship: has_part HGNC:9234 ! MED1 +relationship: has_part HGNC:2370 ! MED14 +relationship: has_part HGNC:2375 ! MED17 +relationship: has_part HGNC:2372 ! MED23 +relationship: has_part HGNC:2376 ! MED26 +relationship: has_part HGNC:2377 ! MED27 +relationship: has_part HGNC:2378 ! MED7 [Term] -id: FPLX:CRTC +id: FPLX:000123 name: CRTC synonym: "CRTC" EXACT [] -is_a: FPLX:root -inverse_is_a: HGNC:CRTC1 -inverse_is_a: HGNC:CRTC2 -inverse_is_a: HGNC:CRTC3 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:16062 ! CRTC1 +relationship: inverse_is_a HGNC:27301 ! CRTC2 +relationship: inverse_is_a HGNC:26148 ! CRTC3 [Term] -id: FPLX:CSNK1 +id: FPLX:000124 name: CSNK1 synonym: "Casein kinase 1" EXACT [] synonym: "casein kinase 1" EXACT [] @@ -2012,17 +2032,17 @@ synonym: "CSNK1" EXACT [] xref: BEL:"CSNK1 Family" xref: MEDSCAN:urn:agi-protfc:casein%20kinase%20I xref: NEXTPROT-FAMILY:03083 -is_a: FPLX:root -inverse_is_a: HGNC:CSNK1A1 -inverse_is_a: HGNC:CSNK1A1L -inverse_is_a: HGNC:CSNK1D -inverse_is_a: HGNC:CSNK1E -inverse_is_a: HGNC:CSNK1G1 -inverse_is_a: HGNC:CSNK1G2 -inverse_is_a: HGNC:CSNK1G3 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:2451 ! CSNK1A1 +relationship: inverse_is_a HGNC:20289 ! CSNK1A1L +relationship: inverse_is_a HGNC:2452 ! CSNK1D +relationship: inverse_is_a HGNC:2453 ! CSNK1E +relationship: inverse_is_a HGNC:2454 ! CSNK1G1 +relationship: inverse_is_a HGNC:2455 ! CSNK1G2 +relationship: inverse_is_a HGNC:2456 ! CSNK1G3 [Term] -id: FPLX:CSNK2 +id: FPLX:000125 name: CSNK2 synonym: "CSNK2" EXACT [] xref: BEL:"CSNK2 Family" @@ -2030,12 +2050,12 @@ xref: RE:R-HSA-5083623 xref: RE:R-HSA-5083624 xref: RE:R-HSA-6805064 xref: RE:R-HSA-6805073 -is_a: FPLX:root -inverse_is_a: HGNC:CSNK2A1 -inverse_is_a: HGNC:CSNK2A2 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:2457 ! CSNK2A1 +relationship: inverse_is_a HGNC:2459 ! CSNK2A2 [Term] -id: FPLX:CTNNA +id: FPLX:000126 name: CTNNA synonym: "a-cathenin" EXACT [] synonym: "alpha catenin" EXACT [] @@ -2045,13 +2065,13 @@ synonym: "catenin α" EXACT [] synonym: "α catenin" EXACT [] synonym: "α-catenin" EXACT [] xref: BEL:"CTNNA Family" -is_a: FPLX:root -inverse_is_a: HGNC:CTNNA1 -inverse_is_a: HGNC:CTNNA2 -inverse_is_a: HGNC:CTNNA3 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:2509 ! CTNNA1 +relationship: inverse_is_a HGNC:2510 ! CTNNA2 +relationship: inverse_is_a HGNC:2511 ! CTNNA3 [Term] -id: FPLX:CUL +id: FPLX:000127 name: CUL synonym: "cullin proteins" EXACT [] synonym: "cullin" EXACT [] @@ -2061,50 +2081,50 @@ xref: MEDSCAN:urn:agi-complex:prophash-c3bac0781a4430da4cf6721b8f7537d9 xref: MEDSCAN:urn:agi-protfc:cullin xref: NEXTPROT-FAMILY:00787 xref: XFAM:PF00888 -is_a: FPLX:root -inverse_is_a: HGNC:CUL1 -inverse_is_a: HGNC:CUL2 -inverse_is_a: HGNC:CUL3 -inverse_is_a: HGNC:CUL4A -inverse_is_a: HGNC:CUL4B -inverse_is_a: HGNC:CUL5 -inverse_is_a: HGNC:CUL7 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:2551 ! CUL1 +relationship: inverse_is_a HGNC:2552 ! CUL2 +relationship: inverse_is_a HGNC:2553 ! CUL3 +relationship: inverse_is_a HGNC:2554 ! CUL4A +relationship: inverse_is_a HGNC:2555 ! CUL4B +relationship: inverse_is_a HGNC:2556 ! CUL5 +relationship: inverse_is_a HGNC:21024 ! CUL7 [Term] -id: FPLX:CXCL_ELR_negative +id: FPLX:000128 name: CXCL-ELR-negative synonym: "ELR (-) CXC chemokines" EXACT [] synonym: "ELR-negative CXC chemokine" EXACT [] synonym: "ELR-negative CXC family" EXACT [] synonym: "non-ELR-CXC chemokines" EXACT [] xref: BEL:"CXCL ELR-Negative Family" -is_a: FPLX:Chemokine -inverse_is_a: HGNC:CXCL10 -inverse_is_a: HGNC:CXCL11 -inverse_is_a: HGNC:CXCL12 -inverse_is_a: HGNC:CXCL13 -inverse_is_a: HGNC:CXCL14 -inverse_is_a: HGNC:CXCL9 -inverse_is_a: HGNC:PF4 +is_a: FPLX:000099 ! Chemokine +relationship: inverse_is_a HGNC:10637 ! CXCL10 +relationship: inverse_is_a HGNC:10638 ! CXCL11 +relationship: inverse_is_a HGNC:10672 ! CXCL12 +relationship: inverse_is_a HGNC:10639 ! CXCL13 +relationship: inverse_is_a HGNC:10640 ! CXCL14 +relationship: inverse_is_a HGNC:7098 ! CXCL9 +relationship: inverse_is_a HGNC:8861 ! PF4 [Term] -id: FPLX:CXCL_ELR_positive +id: FPLX:000129 name: CXCL-ELR-positive synonym: "ELR (+) CXC chemokines" EXACT [] synonym: "ELR-positive CXC chemokine" EXACT [] synonym: "ELR-positive CXC family" EXACT [] xref: BEL:"CXCL ELR-Positive Family" -is_a: FPLX:Chemokine -inverse_is_a: HGNC:CXCL1 -inverse_is_a: HGNC:CXCL2 -inverse_is_a: HGNC:CXCL3 -inverse_is_a: HGNC:CXCL5 -inverse_is_a: HGNC:CXCL6 -inverse_is_a: HGNC:CXCL8 -inverse_is_a: HGNC:PPBP +is_a: FPLX:000099 ! Chemokine +relationship: inverse_is_a HGNC:4602 ! CXCL1 +relationship: inverse_is_a HGNC:4603 ! CXCL2 +relationship: inverse_is_a HGNC:4604 ! CXCL3 +relationship: inverse_is_a HGNC:10642 ! CXCL5 +relationship: inverse_is_a HGNC:10643 ! CXCL6 +relationship: inverse_is_a HGNC:6025 ! CXCL8 +relationship: inverse_is_a HGNC:9240 ! PPBP [Term] -id: FPLX:Cyclin +id: FPLX:000130 name: Cyclin synonym: "cyclin family" EXACT [] synonym: "Cyclin" EXACT [] @@ -2113,34 +2133,34 @@ synonym: "cyclins" EXACT [] xref: MEDSCAN:urn:agi-protfc:cyclin xref: NCIT:C17349 xref: NEXTPROT-FAMILY:00815 -is_a: FPLX:root -inverse_is_a: HGNC:CCNB1 -inverse_is_a: HGNC:CCNB2 -inverse_is_a: HGNC:CCNB3 -inverse_is_a: HGNC:CCNC -inverse_is_a: HGNC:CCNF -inverse_is_a: HGNC:CCNG1 -inverse_is_a: HGNC:CCNG2 -inverse_is_a: HGNC:CCNH -inverse_is_a: HGNC:CCNI -inverse_is_a: HGNC:CCNI2 -inverse_is_a: HGNC:CCNJ -inverse_is_a: HGNC:CCNJL -inverse_is_a: HGNC:CCNK -inverse_is_a: HGNC:CCNL1 -inverse_is_a: HGNC:CCNL2 -inverse_is_a: HGNC:CCNO -inverse_is_a: HGNC:CCNT1 -inverse_is_a: HGNC:CCNT2 -inverse_is_a: HGNC:CCNY -inverse_is_a: HGNC:CCNYL1 -inverse_is_a: HGNC:CCNYL3 -inverse_is_a: FPLX:Cyclin_A -inverse_is_a: FPLX:Cyclin_D -inverse_is_a: FPLX:Cyclin_E - -[Term] -id: FPLX:Cyclin_A +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:1579 ! CCNB1 +relationship: inverse_is_a HGNC:1580 ! CCNB2 +relationship: inverse_is_a HGNC:18709 ! CCNB3 +relationship: inverse_is_a HGNC:1581 ! CCNC +relationship: inverse_is_a HGNC:1591 ! CCNF +relationship: inverse_is_a HGNC:1592 ! CCNG1 +relationship: inverse_is_a HGNC:1593 ! CCNG2 +relationship: inverse_is_a HGNC:1594 ! CCNH +relationship: inverse_is_a HGNC:1595 ! CCNI +relationship: inverse_is_a HGNC:33869 ! CCNI2 +relationship: inverse_is_a HGNC:23434 ! CCNJ +relationship: inverse_is_a HGNC:25876 ! CCNJL +relationship: inverse_is_a HGNC:1596 ! CCNK +relationship: inverse_is_a HGNC:20569 ! CCNL1 +relationship: inverse_is_a HGNC:20570 ! CCNL2 +relationship: inverse_is_a HGNC:18576 ! CCNO +relationship: inverse_is_a HGNC:1599 ! CCNT1 +relationship: inverse_is_a HGNC:1600 ! CCNT2 +relationship: inverse_is_a HGNC:23354 ! CCNY +relationship: inverse_is_a HGNC:26868 ! CCNYL1 +relationship: inverse_is_a HGNC:33206 ! CCNYL3 +relationship: inverse_is_a FPLX:000131 ! Cyclin_A +relationship: inverse_is_a FPLX:000132 ! Cyclin_D +relationship: inverse_is_a FPLX:000133 ! Cyclin_E + +[Term] +id: FPLX:000131 name: Cyclin-A synonym: "Cyclin A" EXACT [] synonym: "cyclin A" EXACT [] @@ -2151,12 +2171,12 @@ xref: RE:R-HSA-174074 xref: RE:R-HSA-5696998 xref: RE:R-HSA-6783051 xref: RE:R-HSA-75202 -is_a: FPLX:Cyclin -inverse_is_a: HGNC:CCNA1 -inverse_is_a: HGNC:CCNA2 +is_a: FPLX:000130 ! Cyclin +relationship: inverse_is_a HGNC:1577 ! CCNA1 +relationship: inverse_is_a HGNC:1578 ! CCNA2 [Term] -id: FPLX:Cyclin_D +id: FPLX:000132 name: Cyclin-D synonym: "Cyclin D" EXACT [] xref: BEL:"CCND Family" @@ -2166,13 +2186,13 @@ xref: NEXTPROT-FAMILY:00818 xref: RE:R-HSA-182582 xref: RE:R-HSA-182700 xref: RE:R-HSA-8938866 -is_a: FPLX:Cyclin -inverse_is_a: HGNC:CCND1 -inverse_is_a: HGNC:CCND2 -inverse_is_a: HGNC:CCND3 +is_a: FPLX:000130 ! Cyclin +relationship: inverse_is_a HGNC:1582 ! CCND1 +relationship: inverse_is_a HGNC:1583 ! CCND2 +relationship: inverse_is_a HGNC:1585 ! CCND3 [Term] -id: FPLX:Cyclin_E +id: FPLX:000133 name: Cyclin-E synonym: "cyclin E" EXACT [] xref: BEL:"CCNE Family" @@ -2183,54 +2203,54 @@ xref: RE:R-HSA-157462 xref: RE:R-HSA-187493 xref: RE:R-HSA-6813837 xref: RE:R-HSA-68373 -is_a: FPLX:Cyclin -inverse_is_a: HGNC:CCNE1 -inverse_is_a: HGNC:CCNE2 +is_a: FPLX:000130 ! Cyclin +relationship: inverse_is_a HGNC:1589 ! CCNE1 +relationship: inverse_is_a HGNC:1590 ! CCNE2 [Term] -id: FPLX:Cyclophilin +id: FPLX:000134 name: Cyclophilin synonym: "cyclophilin" EXACT [] synonym: "cyclophilins" EXACT [] xref: BEL:"Cyclophilin Family" xref: MEDSCAN:urn:agi-protfc:cyclophilins -is_a: FPLX:root -inverse_is_a: HGNC:CWC27 -inverse_is_a: HGNC:PPIA -inverse_is_a: HGNC:PPIB -inverse_is_a: HGNC:PPIC -inverse_is_a: HGNC:PPID -inverse_is_a: HGNC:PPIE -inverse_is_a: HGNC:PPIF -inverse_is_a: HGNC:PPIH -inverse_is_a: HGNC:PPIL1 -inverse_is_a: HGNC:PPIL2 -inverse_is_a: HGNC:PPIL3 -inverse_is_a: HGNC:PPIL4 -inverse_is_a: HGNC:PPIL6 -inverse_is_a: HGNC:PPWD1 -inverse_is_a: HGNC:PPIAL4A -inverse_is_a: HGNC:PPIAL4C -inverse_is_a: HGNC:PPIAL4G - -[Term] -id: FPLX:Cytoplasmic_dynein +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:10664 ! CWC27 +relationship: inverse_is_a HGNC:9253 ! PPIA +relationship: inverse_is_a HGNC:9255 ! PPIB +relationship: inverse_is_a HGNC:9256 ! PPIC +relationship: inverse_is_a HGNC:9257 ! PPID +relationship: inverse_is_a HGNC:9258 ! PPIE +relationship: inverse_is_a HGNC:9259 ! PPIF +relationship: inverse_is_a HGNC:14651 ! PPIH +relationship: inverse_is_a HGNC:9260 ! PPIL1 +relationship: inverse_is_a HGNC:9261 ! PPIL2 +relationship: inverse_is_a HGNC:9262 ! PPIL3 +relationship: inverse_is_a HGNC:15702 ! PPIL4 +relationship: inverse_is_a HGNC:21557 ! PPIL6 +relationship: inverse_is_a HGNC:28954 ! PPWD1 +relationship: inverse_is_a HGNC:24369 ! PPIAL4A +relationship: inverse_is_a HGNC:33995 ! PPIAL4C +relationship: inverse_is_a HGNC:33996 ! PPIAL4G + +[Term] +id: FPLX:000135 name: Cytoplasmic-dynein synonym: "cytoplasmic dynein" EXACT [] xref: BEL:"Cytoplasmic Dynein Complex" xref: GO:0005868 -is_a: FPLX:root -has_part: HGNC:DYNC1H1 -has_part: HGNC:DYNC1I1 -has_part: HGNC:DYNC1I2 -has_part: HGNC:DYNC1LI1 -has_part: HGNC:DYNC1LI2 -has_part: HGNC:DYNLL1 -has_part: HGNC:DYNLRB1 -has_part: HGNC:DYNLRB2 - -[Term] -id: FPLX:DDR +is_a: FPLX:000000 ! famplex +relationship: has_part HGNC:2961 ! DYNC1H1 +relationship: has_part HGNC:2963 ! DYNC1I1 +relationship: has_part HGNC:2964 ! DYNC1I2 +relationship: has_part HGNC:18745 ! DYNC1LI1 +relationship: has_part HGNC:2966 ! DYNC1LI2 +relationship: has_part HGNC:15476 ! DYNLL1 +relationship: has_part HGNC:15468 ! DYNLRB1 +relationship: has_part HGNC:15467 ! DYNLRB2 + +[Term] +id: FPLX:000136 name: DDR synonym: "discoidin domain receptor family" EXACT [] synonym: "discoidin domain receptors" EXACT [] @@ -2238,27 +2258,27 @@ synonym: "discoidin domain-containing receptor" EXACT [] xref: BEL:"DDR Family" xref: MEDSCAN:urn:agi-aopfc:0000252 xref: XFAM:PF08841 -is_a: FPLX:root -inverse_is_a: HGNC:DDR1 -inverse_is_a: HGNC:DDR2 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:2730 ! DDR1 +relationship: inverse_is_a HGNC:2731 ! DDR2 [Term] -id: FPLX:Death_receptor +id: FPLX:000137 name: Death-receptor synonym: "death receptor" EXACT [] synonym: "death receptors" EXACT [] xref: GO:0005035 -is_a: FPLX:root -inverse_is_a: HGNC:TNFRSF1A -inverse_is_a: HGNC:TNFRSF1B -inverse_is_a: HGNC:TNFRSF10A -inverse_is_a: HGNC:TNFRSF10B -inverse_is_a: HGNC:TNFRSF10C -inverse_is_a: HGNC:TNFRSF10D -inverse_is_a: HGNC:FAS +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:11916 ! TNFRSF1A +relationship: inverse_is_a HGNC:11917 ! TNFRSF1B +relationship: inverse_is_a HGNC:11904 ! TNFRSF10A +relationship: inverse_is_a HGNC:11905 ! TNFRSF10B +relationship: inverse_is_a HGNC:11906 ! TNFRSF10C +relationship: inverse_is_a HGNC:11907 ! TNFRSF10D +relationship: inverse_is_a HGNC:11920 ! FAS [Term] -id: FPLX:Desmoglein +id: FPLX:000138 name: Desmoglein synonym: "desmoglein" EXACT [] synonym: "desmogleins" EXACT [] @@ -2267,14 +2287,14 @@ xref: IP:IPR009123 xref: MEDSCAN:urn:agi-protfc:desmoglein xref: RE:R-HSA-6814694 xref: RE:R-HSA-8847714 -is_a: FPLX:root -inverse_is_a: HGNC:DSG1 -inverse_is_a: HGNC:DSG2 -inverse_is_a: HGNC:DSG3 -inverse_is_a: HGNC:DSG4 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:3048 ! DSG1 +relationship: inverse_is_a HGNC:3049 ! DSG2 +relationship: inverse_is_a HGNC:3050 ! DSG3 +relationship: inverse_is_a HGNC:21307 ! DSG4 [Term] -id: FPLX:DGC +id: FPLX:000139 name: DGC synonym: "DGC" EXACT [] synonym: "dystrophin glycoprotein complex" EXACT [] @@ -2283,26 +2303,26 @@ synonym: "dystrophin-associated glycoprotein complex" EXACT [] synonym: "dystrophin-glycoprotein complex" EXACT [] xref: BEL:"Dystrophin Associated Glycoprotein Complex" xref: GO:0016010 -is_a: FPLX:root -has_part: HGNC:DAG1 -has_part: HGNC:DMD -has_part: HGNC:DTNA -has_part: HGNC:DTNB -has_part: HGNC:NOS1 -has_part: HGNC:SGCA -has_part: HGNC:SGCB -has_part: HGNC:SGCD -has_part: HGNC:SGCE -has_part: HGNC:SGCZ -has_part: HGNC:SNTA1 -has_part: HGNC:SNTB1 -has_part: HGNC:SNTG1 -has_part: HGNC:SNTG2 -has_part: HGNC:SSPN -has_part: HGNC:UTRN - -[Term] -id: FPLX:DGK +is_a: FPLX:000000 ! famplex +relationship: has_part HGNC:2666 ! DAG1 +relationship: has_part HGNC:2928 ! DMD +relationship: has_part HGNC:3057 ! DTNA +relationship: has_part HGNC:3058 ! DTNB +relationship: has_part HGNC:7872 ! NOS1 +relationship: has_part HGNC:10805 ! SGCA +relationship: has_part HGNC:10806 ! SGCB +relationship: has_part HGNC:10807 ! SGCD +relationship: has_part HGNC:10808 ! SGCE +relationship: has_part HGNC:14075 ! SGCZ +relationship: has_part HGNC:11167 ! SNTA1 +relationship: has_part HGNC:11168 ! SNTB1 +relationship: has_part HGNC:13740 ! SNTG1 +relationship: has_part HGNC:13741 ! SNTG2 +relationship: has_part HGNC:11322 ! SSPN +relationship: has_part HGNC:12635 ! UTRN + +[Term] +id: FPLX:000140 name: DGK synonym: "DAG kinase" EXACT [] synonym: "DGK" EXACT [] @@ -2312,20 +2332,20 @@ xref: BEL:"DGK Family" xref: ECCODE:2.7.1.107 xref: IP:IPR000756 xref: RE:R-HSA-426070 -is_a: FPLX:root -inverse_is_a: HGNC:DGKA -inverse_is_a: HGNC:DGKB -inverse_is_a: HGNC:DGKD -inverse_is_a: HGNC:DGKG -inverse_is_a: HGNC:DGKH -inverse_is_a: HGNC:DGKQ -inverse_is_a: HGNC:DGKZ -inverse_is_a: HGNC:DGKE -inverse_is_a: HGNC:DGKI -inverse_is_a: HGNC:DGKK - -[Term] -id: FPLX:DNA_polymerase_delta +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:2849 ! DGKA +relationship: inverse_is_a HGNC:2850 ! DGKB +relationship: inverse_is_a HGNC:2851 ! DGKD +relationship: inverse_is_a HGNC:2853 ! DGKG +relationship: inverse_is_a HGNC:2854 ! DGKH +relationship: inverse_is_a HGNC:2856 ! DGKQ +relationship: inverse_is_a HGNC:2857 ! DGKZ +relationship: inverse_is_a HGNC:2852 ! DGKE +relationship: inverse_is_a HGNC:2855 ! DGKI +relationship: inverse_is_a HGNC:32395 ! DGKK + +[Term] +id: FPLX:000141 name: DNA-polymerase-delta synonym: "DNA polymerase delta" EXACT [] synonym: "DNA polymerase δ" EXACT [] @@ -2337,14 +2357,14 @@ xref: BEL:"DNA Polymerase delta Complex" xref: GO:0043625 xref: NCIT:C16511 xref: RE:R-HSA-68450 -is_a: FPLX:root -has_part: HGNC:POLD1 -has_part: HGNC:POLD2 -has_part: HGNC:POLD3 -has_part: HGNC:POLD4 +is_a: FPLX:000000 ! famplex +relationship: has_part HGNC:9175 ! POLD1 +relationship: has_part HGNC:9176 ! POLD2 +relationship: has_part HGNC:20932 ! POLD3 +relationship: has_part HGNC:14106 ! POLD4 [Term] -id: FPLX:DNM +id: FPLX:000142 name: DNM synonym: "dynamin family" EXACT [] synonym: "dynamin" EXACT [] @@ -2353,13 +2373,13 @@ xref: RE:R-HSA-2213185 xref: RE:R-HSA-446847 xref: RE:R-HSA-8868235 xref: RE:R-HSA-8868609 -is_a: FPLX:root -inverse_is_a: HGNC:DNM1 -inverse_is_a: HGNC:DNM2 -inverse_is_a: HGNC:DNM3 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:2972 ! DNM1 +relationship: inverse_is_a HGNC:2974 ! DNM2 +relationship: inverse_is_a HGNC:29125 ! DNM3 [Term] -id: FPLX:DRD +id: FPLX:000143 name: DRD synonym: "dopamine receptor" EXACT [] synonym: "dopamine receptors" EXACT [] @@ -2367,27 +2387,27 @@ xref: BEL:"DRD Family" xref: GO:0004952 xref: IP:IPR000929 xref: NCIT:C17066 -is_a: FPLX:root -inverse_is_a: HGNC:DRD1 -inverse_is_a: HGNC:DRD2 -inverse_is_a: HGNC:DRD3 -inverse_is_a: HGNC:DRD4 -inverse_is_a: HGNC:DRD5 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:3020 ! DRD1 +relationship: inverse_is_a HGNC:3023 ! DRD2 +relationship: inverse_is_a HGNC:3024 ! DRD3 +relationship: inverse_is_a HGNC:3025 ! DRD4 +relationship: inverse_is_a HGNC:3026 ! DRD5 [Term] -id: FPLX:DUSP +id: FPLX:000144 name: DUSP synonym: "DUSP" EXACT [] -is_a: FPLX:root -inverse_is_a: HGNC:DUSP1 -inverse_is_a: HGNC:DUSP2 -inverse_is_a: HGNC:DUSP3 -inverse_is_a: HGNC:DUSP4 -inverse_is_a: HGNC:DUSP5 -inverse_is_a: HGNC:DUSP6 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:3064 ! DUSP1 +relationship: inverse_is_a HGNC:3068 ! DUSP2 +relationship: inverse_is_a HGNC:3069 ! DUSP3 +relationship: inverse_is_a HGNC:3070 ! DUSP4 +relationship: inverse_is_a HGNC:3071 ! DUSP5 +relationship: inverse_is_a HGNC:3072 ! DUSP6 [Term] -id: FPLX:DVL +id: FPLX:000145 name: DVL synonym: "dishevelled" EXACT [] synonym: "Dvl" EXACT [] @@ -2402,52 +2422,52 @@ xref: RE:R-HSA-3858467 xref: RE:R-HSA-3858479 xref: RE:R-HSA-4652685 xref: SIGNOR:SIGNOR-PF10 -is_a: FPLX:root -inverse_is_a: HGNC:DVL1 -inverse_is_a: HGNC:DVL2 -inverse_is_a: HGNC:DVL3 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:3084 ! DVL1 +relationship: inverse_is_a HGNC:3086 ! DVL2 +relationship: inverse_is_a HGNC:3087 ! DVL3 [Term] -id: FPLX:DYRK +id: FPLX:000146 name: DYRK synonym: "DYRK" EXACT [] xref: NEXTPROT-FAMILY:03091 -is_a: FPLX:root -inverse_is_a: HGNC:DYRK1A -inverse_is_a: HGNC:DYRK1B -inverse_is_a: HGNC:DYRK2 -inverse_is_a: HGNC:DYRK3 -inverse_is_a: HGNC:DYRK4 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:3091 ! DYRK1A +relationship: inverse_is_a HGNC:3092 ! DYRK1B +relationship: inverse_is_a HGNC:3093 ! DYRK2 +relationship: inverse_is_a HGNC:3094 ! DYRK3 +relationship: inverse_is_a HGNC:3095 ! DYRK4 [Term] -id: FPLX:E2F +id: FPLX:000147 name: E2F synonym: "E2F" EXACT [] xref: BEL:"E2F Family" xref: IP:IPR015633 xref: MEDSCAN:urn:agi-aopfc:0000099 xref: MEDSCAN:urn:agi-complex:prophash-40bc2e4348830d6f7bdacd573fd7c388 -is_a: FPLX:root -inverse_is_a: HGNC:E2F1 -inverse_is_a: HGNC:E2F2 -inverse_is_a: HGNC:E2F3 -inverse_is_a: HGNC:E2F4 -inverse_is_a: HGNC:E2F5 -inverse_is_a: HGNC:E2F6 -inverse_is_a: HGNC:E2F7 -inverse_is_a: HGNC:E2F8 - -[Term] -id: FPLX:E3_Ub_ligase +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:3113 ! E2F1 +relationship: inverse_is_a HGNC:3114 ! E2F2 +relationship: inverse_is_a HGNC:3115 ! E2F3 +relationship: inverse_is_a HGNC:3118 ! E2F4 +relationship: inverse_is_a HGNC:3119 ! E2F5 +relationship: inverse_is_a HGNC:3120 ! E2F6 +relationship: inverse_is_a HGNC:23820 ! E2F7 +relationship: inverse_is_a HGNC:24727 ! E2F8 + +[Term] +id: FPLX:000148 name: E3-Ub-ligase synonym: "E3 ubiquitin ligase" EXACT [] synonym: "E3" EXACT [] xref: XFAM:PF12483 xref: RE:R-HSA-976075 -is_a: FPLX:root +is_a: FPLX:000000 ! famplex [Term] -id: FPLX:EDN +id: FPLX:000149 name: EDN synonym: "endothelin" EXACT [] synonym: "endothelins" EXACT [] @@ -2458,110 +2478,110 @@ xref: IP:IPR020475 xref: MEDSCAN:urn:agi-protfc:endothelin xref: XFAM:PF00322 xref: RE:R-HSA-388544 -is_a: FPLX:root -inverse_is_a: HGNC:EDN1 -inverse_is_a: HGNC:EDN2 -inverse_is_a: HGNC:EDN3 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:3176 ! EDN1 +relationship: inverse_is_a HGNC:3177 ! EDN2 +relationship: inverse_is_a HGNC:3178 ! EDN3 [Term] -id: FPLX:EGFR_ligand +id: FPLX:000150 name: EGFR-ligand synonym: "EGFR ligand" EXACT [] synonym: "EGFR ligands" EXACT [] xref: BEL:"EGFR Ligand Family" xref: GO:0005154 -is_a: FPLX:root -inverse_is_a: HGNC:AREG -inverse_is_a: HGNC:EGF -inverse_is_a: HGNC:TGFA -inverse_is_a: HGNC:HBEGF -inverse_is_a: HGNC:BTC -inverse_is_a: HGNC:EREG -inverse_is_a: HGNC:EPGN +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:651 ! AREG +relationship: inverse_is_a HGNC:3229 ! EGF +relationship: inverse_is_a HGNC:11765 ! TGFA +relationship: inverse_is_a HGNC:3059 ! HBEGF +relationship: inverse_is_a HGNC:1121 ! BTC +relationship: inverse_is_a HGNC:3443 ! EREG +relationship: inverse_is_a HGNC:17470 ! EPGN [Term] -id: FPLX:EGR +id: FPLX:000151 name: EGR synonym: "early growth response proteins" EXACT [] synonym: "EGR" EXACT [] xref: BEL:"EGR Family" -is_a: FPLX:root -inverse_is_a: HGNC:EGR1 -inverse_is_a: HGNC:EGR2 -inverse_is_a: HGNC:EGR3 -inverse_is_a: HGNC:EGR4 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:3238 ! EGR1 +relationship: inverse_is_a HGNC:3239 ! EGR2 +relationship: inverse_is_a HGNC:3240 ! EGR3 +relationship: inverse_is_a HGNC:3241 ! EGR4 [Term] -id: FPLX:EIF2B +id: FPLX:000152 name: EIF2B synonym: "EIF2B" EXACT [] synonym: "eIF2B" EXACT [] xref: BEL:"EIF2B Complex" xref: NCIT:C18162 xref: RE:R-HSA-72526 -is_a: FPLX:root -has_part: HGNC:EIF2B1 -has_part: HGNC:EIF2B2 -has_part: HGNC:EIF2B3 -has_part: HGNC:EIF2B4 -has_part: HGNC:EIF2B5 +is_a: FPLX:000000 ! famplex +relationship: has_part HGNC:3257 ! EIF2B1 +relationship: has_part HGNC:3258 ! EIF2B2 +relationship: has_part HGNC:3259 ! EIF2B3 +relationship: has_part HGNC:3260 ! EIF2B4 +relationship: has_part HGNC:3261 ! EIF2B5 [Term] -id: FPLX:EIF4A +id: FPLX:000153 name: EIF4A synonym: "eIF4A" EXACT [] synonym: "eukaryotic initiation factor-4A" EXACT [] xref: BEL:"EIF4A Family" xref: NEXTPROT-FAMILY:00921 xref: RE:R-HSA-429842 -is_a: FPLX:root -inverse_is_a: HGNC:EIF4A1 -inverse_is_a: HGNC:EIF4A2 -inverse_is_a: HGNC:EIF4A3 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:3282 ! EIF4A1 +relationship: inverse_is_a HGNC:3284 ! EIF4A2 +relationship: inverse_is_a HGNC:18683 ! EIF4A3 [Term] -id: FPLX:EIF4EBP +id: FPLX:000154 name: EIF4EBP synonym: "4EBP" EXACT [] synonym: "initiation factor 4E binding proteins" EXACT [] xref: BEL:"EIF4EBP Family" xref: GO:0008190 xref: IP:IPR008606 -is_a: FPLX:root -inverse_is_a: HGNC:EIF4EBP1 -inverse_is_a: HGNC:EIF4EBP2 -inverse_is_a: HGNC:EIF4EBP3 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:3288 ! EIF4EBP1 +relationship: inverse_is_a HGNC:3289 ! EIF4EBP2 +relationship: inverse_is_a HGNC:3290 ! EIF4EBP3 [Term] -id: FPLX:EIF4G +id: FPLX:000155 name: EIF4G synonym: "eIF4G" EXACT [] xref: XFAM:PF02854 xref: RE:R-HSA-1678828 -is_a: FPLX:root -inverse_is_a: HGNC:EIF4G1 -inverse_is_a: HGNC:EIF4G2 -inverse_is_a: HGNC:EIF4G3 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:3296 ! EIF4G1 +relationship: inverse_is_a HGNC:3297 ! EIF4G2 +relationship: inverse_is_a HGNC:3298 ! EIF4G3 [Term] -id: FPLX:ELA +id: FPLX:000156 name: ELA synonym: "elastase" EXACT [] xref: BEL:"ELA Family" xref: NEXTPROT-FAMILY:02762 -is_a: FPLX:root -inverse_is_a: HGNC:AZU1 -inverse_is_a: HGNC:CELA1 -inverse_is_a: HGNC:CELA2A -inverse_is_a: HGNC:CELA2B -inverse_is_a: HGNC:CELA3A -inverse_is_a: HGNC:CELA3B -inverse_is_a: HGNC:CTRC -inverse_is_a: HGNC:ELANE -inverse_is_a: HGNC:PRTN3 - -[Term] -id: FPLX:ENO +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:913 ! AZU1 +relationship: inverse_is_a HGNC:3308 ! CELA1 +relationship: inverse_is_a HGNC:24609 ! CELA2A +relationship: inverse_is_a HGNC:29995 ! CELA2B +relationship: inverse_is_a HGNC:15944 ! CELA3A +relationship: inverse_is_a HGNC:15945 ! CELA3B +relationship: inverse_is_a HGNC:2523 ! CTRC +relationship: inverse_is_a HGNC:3309 ! ELANE +relationship: inverse_is_a HGNC:9495 ! PRTN3 + +[Term] +id: FPLX:000157 name: ENO synonym: "enolase" EXACT [] xref: BEL:"ENO Family" @@ -2569,14 +2589,14 @@ xref: IP:IPR000941 xref: IP:IPR020810 xref: IP:IPR020811 xref: NEXTPROT-FAMILY:01112 -is_a: FPLX:root -inverse_is_a: HGNC:ENO1 -inverse_is_a: HGNC:ENO2 -inverse_is_a: HGNC:ENO3 -inverse_is_a: HGNC:ENO4 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:3350 ! ENO1 +relationship: inverse_is_a HGNC:3353 ! ENO2 +relationship: inverse_is_a HGNC:3354 ! ENO3 +relationship: inverse_is_a HGNC:31670 ! ENO4 [Term] -id: FPLX:Ephrin_receptor +id: FPLX:000158 name: Ephrin-receptor synonym: "Eph receptor" EXACT [] synonym: "Eph receptors" EXACT [] @@ -2588,51 +2608,51 @@ xref: IP:IPR016257 xref: IP:IPR027936 xref: NCIT:C18606 xref: NEXTPROT-FAMILY:03124 -is_a: FPLX:root -inverse_is_a: HGNC:EPHA1 -inverse_is_a: HGNC:EPHA2 -inverse_is_a: HGNC:EPHA3 -inverse_is_a: HGNC:EPHA4 -inverse_is_a: HGNC:EPHA5 -inverse_is_a: HGNC:EPHA6 -inverse_is_a: HGNC:EPHA7 -inverse_is_a: HGNC:EPHA8 -inverse_is_a: HGNC:EPHB1 -inverse_is_a: HGNC:EPHB2 -inverse_is_a: HGNC:EPHB3 -inverse_is_a: HGNC:EPHB4 -inverse_is_a: HGNC:EPHB6 -inverse_is_a: HGNC:EPHA10 - -[Term] -id: FPLX:EPN +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:3385 ! EPHA1 +relationship: inverse_is_a HGNC:3386 ! EPHA2 +relationship: inverse_is_a HGNC:3387 ! EPHA3 +relationship: inverse_is_a HGNC:3388 ! EPHA4 +relationship: inverse_is_a HGNC:3389 ! EPHA5 +relationship: inverse_is_a HGNC:19296 ! EPHA6 +relationship: inverse_is_a HGNC:3390 ! EPHA7 +relationship: inverse_is_a HGNC:3391 ! EPHA8 +relationship: inverse_is_a HGNC:3392 ! EPHB1 +relationship: inverse_is_a HGNC:3393 ! EPHB2 +relationship: inverse_is_a HGNC:3394 ! EPHB3 +relationship: inverse_is_a HGNC:3395 ! EPHB4 +relationship: inverse_is_a HGNC:3396 ! EPHB6 +relationship: inverse_is_a HGNC:19987 ! EPHA10 + +[Term] +id: FPLX:000159 name: EPN synonym: "epsin" EXACT [] synonym: "epsins" EXACT [] xref: BEL:"EPN Family" xref: NEXTPROT-FAMILY:01121 -is_a: FPLX:root -inverse_is_a: HGNC:EPN1 -inverse_is_a: HGNC:EPN2 -inverse_is_a: HGNC:EPN3 -inverse_is_a: HGNC:CLINT1 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:21604 ! EPN1 +relationship: inverse_is_a HGNC:18639 ! EPN2 +relationship: inverse_is_a HGNC:18235 ! EPN3 +relationship: inverse_is_a HGNC:23186 ! CLINT1 [Term] -id: FPLX:ERBB +id: FPLX:000160 name: ERBB synonym: "ErbB" EXACT [] synonym: "erbB" EXACT [] xref: BEL:"EGFR/ERBB Family" xref: IP:IPR016245 xref: NCIT:C17763 -is_a: FPLX:root -inverse_is_a: HGNC:EGFR -inverse_is_a: HGNC:ERBB2 -inverse_is_a: HGNC:ERBB3 -inverse_is_a: HGNC:ERBB4 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:3236 ! EGFR +relationship: inverse_is_a HGNC:3430 ! ERBB2 +relationship: inverse_is_a HGNC:3431 ! ERBB3 +relationship: inverse_is_a HGNC:3432 ! ERBB4 [Term] -id: FPLX:ERK +id: FPLX:000161 name: ERK synonym: "ERK 1/2" EXACT [] synonym: "ERK MAPK" EXACT [] @@ -2666,22 +2686,22 @@ xref: RE:R-HSA-5674341 xref: RE:R-HSA-5675361 xref: RE:R-HSA-5675363 xref: SIGNOR:SIGNOR-PF1 -is_a: FPLX:MAPK -inverse_is_a: HGNC:MAPK1 -inverse_is_a: HGNC:MAPK3 +is_a: FPLX:000283 ! MAPK +relationship: inverse_is_a HGNC:6871 ! MAPK1 +relationship: inverse_is_a HGNC:6877 ! MAPK3 [Term] -id: FPLX:ESR +id: FPLX:000162 name: ESR synonym: "ER" EXACT [] synonym: "ESR" EXACT [] xref: BEL:"ESR Family" -is_a: FPLX:root -inverse_is_a: HGNC:ESR1 -inverse_is_a: HGNC:ESR2 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:3467 ! ESR1 +relationship: inverse_is_a HGNC:3468 ! ESR2 [Term] -id: FPLX:ETS +id: FPLX:000163 name: ETS synonym: "ETS" EXACT [] xref: BEL:"ETS Family" @@ -2690,12 +2710,12 @@ xref: XFAM:PF00178 xref: RE:R-HSA-3132719 xref: RE:R-HSA-3132724 xref: RE:R-HSA-3200029 -is_a: FPLX:root -inverse_is_a: HGNC:ETS1 -inverse_is_a: HGNC:ETS2 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:3488 ! ETS1 +relationship: inverse_is_a HGNC:3489 ! ETS2 [Term] -id: FPLX:EXOC +id: FPLX:000164 name: EXOC synonym: "EXOC" EXACT [] synonym: "exocyst complex" EXACT [] @@ -2703,58 +2723,58 @@ synonym: "exocyst" EXACT [] xref: GO:0000145 xref: RE:R-HSA-264974 xref: RE:R-HSA-5623453 -is_a: FPLX:root -has_part: HGNC:EXOC1 -has_part: HGNC:EXOC2 -has_part: HGNC:EXOC3 -has_part: HGNC:EXOC4 -has_part: HGNC:EXOC5 -has_part: HGNC:EXOC6 -has_part: HGNC:EXOC7 -has_part: HGNC:EXOC8 - -[Term] -id: FPLX:EXT +is_a: FPLX:000000 ! famplex +relationship: has_part HGNC:30380 ! EXOC1 +relationship: has_part HGNC:24968 ! EXOC2 +relationship: has_part HGNC:30378 ! EXOC3 +relationship: has_part HGNC:30389 ! EXOC4 +relationship: has_part HGNC:10696 ! EXOC5 +relationship: has_part HGNC:23196 ! EXOC6 +relationship: has_part HGNC:23214 ! EXOC7 +relationship: has_part HGNC:24659 ! EXOC8 + +[Term] +id: FPLX:000165 name: EXT synonym: "Exostosin glycosyltransferase family" EXACT [] synonym: "exostosin glycosyltransferase family" EXACT [] synonym: "EXT" EXACT [] -is_a: FPLX:Glycosyltransferase -inverse_is_a: HGNC:EXTL1 -inverse_is_a: HGNC:EXTL2 -inverse_is_a: HGNC:EXTL3 -inverse_is_a: HGNC:EXT1 -inverse_is_a: HGNC:EXT2 +is_a: FPLX:000198 ! Glycosyltransferase +relationship: inverse_is_a HGNC:3515 ! EXTL1 +relationship: inverse_is_a HGNC:3516 ! EXTL2 +relationship: inverse_is_a HGNC:3518 ! EXTL3 +relationship: inverse_is_a HGNC:3512 ! EXT1 +relationship: inverse_is_a HGNC:3513 ! EXT2 [Term] -id: FPLX:FANC +id: FPLX:000166 name: FANC synonym: "FANC proteins" EXACT [] synonym: "FANC" EXACT [] -is_a: FPLX:root -inverse_is_a: HGNC:FANCA -inverse_is_a: HGNC:FANCB -inverse_is_a: HGNC:FANCC -inverse_is_a: HGNC:BRCA2 -inverse_is_a: HGNC:FANCD2 -inverse_is_a: HGNC:FANCE -inverse_is_a: HGNC:FANCF -inverse_is_a: HGNC:FANCG -inverse_is_a: HGNC:FANCI -inverse_is_a: HGNC:BRIP1 -inverse_is_a: HGNC:FANCL -inverse_is_a: HGNC:FANCM -inverse_is_a: HGNC:PALB2 -inverse_is_a: HGNC:RAD51C -inverse_is_a: HGNC:SLX4 -inverse_is_a: HGNC:ERCC4 -inverse_is_a: HGNC:RAD51 -inverse_is_a: HGNC:BRCA1 -inverse_is_a: HGNC:UBE2T -inverse_is_a: HGNC:XRCC2 - -[Term] -id: FPLX:FGF +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:3582 ! FANCA +relationship: inverse_is_a HGNC:3583 ! FANCB +relationship: inverse_is_a HGNC:3584 ! FANCC +relationship: inverse_is_a HGNC:1101 ! BRCA2 +relationship: inverse_is_a HGNC:3585 ! FANCD2 +relationship: inverse_is_a HGNC:3586 ! FANCE +relationship: inverse_is_a HGNC:3587 ! FANCF +relationship: inverse_is_a HGNC:3588 ! FANCG +relationship: inverse_is_a HGNC:25568 ! FANCI +relationship: inverse_is_a HGNC:20473 ! BRIP1 +relationship: inverse_is_a HGNC:20748 ! FANCL +relationship: inverse_is_a HGNC:23168 ! FANCM +relationship: inverse_is_a HGNC:26144 ! PALB2 +relationship: inverse_is_a HGNC:9820 ! RAD51C +relationship: inverse_is_a HGNC:23845 ! SLX4 +relationship: inverse_is_a HGNC:3436 ! ERCC4 +relationship: inverse_is_a HGNC:9817 ! RAD51 +relationship: inverse_is_a HGNC:1100 ! BRCA1 +relationship: inverse_is_a HGNC:25009 ! UBE2T +relationship: inverse_is_a HGNC:12829 ! XRCC2 + +[Term] +id: FPLX:000167 name: FGF synonym: "FGF" EXACT [] xref: BEL:"FGF Family" @@ -2762,32 +2782,32 @@ xref: GO:0005162 xref: IP:IPR002209 xref: XFAM:PF00167 xref: SIGNOR:SIGNOR-PF8 -is_a: FPLX:root -inverse_is_a: HGNC:FGF1 -inverse_is_a: HGNC:FGF2 -inverse_is_a: HGNC:FGF3 -inverse_is_a: HGNC:FGF4 -inverse_is_a: HGNC:FGF5 -inverse_is_a: HGNC:FGF6 -inverse_is_a: HGNC:FGF7 -inverse_is_a: HGNC:FGF8 -inverse_is_a: HGNC:FGF9 -inverse_is_a: HGNC:FGF10 -inverse_is_a: HGNC:FGF11 -inverse_is_a: HGNC:FGF12 -inverse_is_a: HGNC:FGF13 -inverse_is_a: HGNC:FGF14 -inverse_is_a: HGNC:FGF16 -inverse_is_a: HGNC:FGF17 -inverse_is_a: HGNC:FGF18 -inverse_is_a: HGNC:FGF19 -inverse_is_a: HGNC:FGF20 -inverse_is_a: HGNC:FGF21 -inverse_is_a: HGNC:FGF22 -inverse_is_a: HGNC:FGF23 - -[Term] -id: FPLX:FGFR +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:3665 ! FGF1 +relationship: inverse_is_a HGNC:3676 ! FGF2 +relationship: inverse_is_a HGNC:3681 ! FGF3 +relationship: inverse_is_a HGNC:3682 ! FGF4 +relationship: inverse_is_a HGNC:3683 ! FGF5 +relationship: inverse_is_a HGNC:3684 ! FGF6 +relationship: inverse_is_a HGNC:3685 ! FGF7 +relationship: inverse_is_a HGNC:3686 ! FGF8 +relationship: inverse_is_a HGNC:3687 ! FGF9 +relationship: inverse_is_a HGNC:3666 ! FGF10 +relationship: inverse_is_a HGNC:3667 ! FGF11 +relationship: inverse_is_a HGNC:3668 ! FGF12 +relationship: inverse_is_a HGNC:3670 ! FGF13 +relationship: inverse_is_a HGNC:3671 ! FGF14 +relationship: inverse_is_a HGNC:3672 ! FGF16 +relationship: inverse_is_a HGNC:3673 ! FGF17 +relationship: inverse_is_a HGNC:3674 ! FGF18 +relationship: inverse_is_a HGNC:3675 ! FGF19 +relationship: inverse_is_a HGNC:3677 ! FGF20 +relationship: inverse_is_a HGNC:3678 ! FGF21 +relationship: inverse_is_a HGNC:3679 ! FGF22 +relationship: inverse_is_a HGNC:3680 ! FGF23 + +[Term] +id: FPLX:000168 name: FGFR synonym: "FGFR" EXACT [] xref: BEL:"FGFR Family" @@ -2795,15 +2815,15 @@ xref: GO:0005007 xref: IP:IPR016248 xref: NCIT:C17297 xref: SIGNOR:SIGNOR-PF23 -is_a: FPLX:root -inverse_is_a: HGNC:FGFR1 -inverse_is_a: HGNC:FGFR2 -inverse_is_a: HGNC:FGFR3 -inverse_is_a: HGNC:FGFR4 -inverse_is_a: HGNC:FGFRL1 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:3688 ! FGFR1 +relationship: inverse_is_a HGNC:3689 ! FGFR2 +relationship: inverse_is_a HGNC:3690 ! FGFR3 +relationship: inverse_is_a HGNC:3691 ! FGFR4 +relationship: inverse_is_a HGNC:3693 ! FGFRL1 [Term] -id: FPLX:Fibrinogen +id: FPLX:000169 name: Fibrinogen synonym: "fibrinogen" EXACT [] xref: BEL:"Fibrinogen Complex" @@ -2816,13 +2836,13 @@ xref: RE:R-HSA-139934 xref: RE:R-HSA-140586 xref: RE:R-HSA-140919 xref: RE:R-HSA-8870680 -is_a: FPLX:root -has_part: HGNC:FGA -has_part: HGNC:FGB -has_part: HGNC:FGG +is_a: FPLX:000000 ! famplex +relationship: has_part HGNC:3661 ! FGA +relationship: has_part HGNC:3662 ! FGB +relationship: has_part HGNC:3694 ! FGG [Term] -id: FPLX:FLOT +id: FPLX:000170 name: FLOT synonym: "flotillin" EXACT [] xref: BEL:"FLOT Family" @@ -2831,49 +2851,49 @@ xref: IP:IPR031905 xref: MEDSCAN:urn:agi-protfc:flotillin xref: XFAM:PF15975 xref: RE:R-HSA-8849894 -is_a: FPLX:root -inverse_is_a: HGNC:FLOT1 -inverse_is_a: HGNC:FLOT2 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:3757 ! FLOT1 +relationship: inverse_is_a HGNC:3758 ! FLOT2 [Term] -id: FPLX:FLRT +id: FPLX:000171 name: FLRT synonym: "FLRT family" EXACT [] synonym: "Flrt family" EXACT [] synonym: "FLRT proteins" EXACT [] xref: BEL:"FLRT Family" xref: RE:R-HSA-5656056 -is_a: FPLX:root -inverse_is_a: HGNC:FLRT1 -inverse_is_a: HGNC:FLRT2 -inverse_is_a: HGNC:FLRT3 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:3760 ! FLRT1 +relationship: inverse_is_a HGNC:3761 ! FLRT2 +relationship: inverse_is_a HGNC:3762 ! FLRT3 [Term] -id: FPLX:FNT +id: FPLX:000172 name: FNT synonym: "farnesyltransferase" EXACT [] synonym: "FTase" EXACT [] synonym: "protein farnesyltransferase" EXACT [] xref: ECCODE:2.5.1.58 xref: RE:R-HSA-2530496 -is_a: FPLX:root -has_part: HGNC:FNTA -has_part: HGNC:FNTB +is_a: FPLX:000000 ! famplex +relationship: has_part HGNC:3782 ! FNTA +relationship: has_part HGNC:3785 ! FNTB [Term] -id: FPLX:FOS_family +id: FPLX:000173 name: FOS-family synonym: "FOS" EXACT [] synonym: "Fos" EXACT [] xref: NEXTPROT-FAMILY:00408 -part_of: FPLX:AP1 -inverse_is_a: HGNC:FOS -inverse_is_a: HGNC:FOSB -inverse_is_a: HGNC:FOSL1 -inverse_is_a: HGNC:FOSL2 +relationship: part_of FPLX:000048 ! AP1 +relationship: inverse_is_a HGNC:3796 ! FOS +relationship: inverse_is_a HGNC:3797 ! FOSB +relationship: inverse_is_a HGNC:13718 ! FOSL1 +relationship: inverse_is_a HGNC:3798 ! FOSL2 [Term] -id: FPLX:FOXO +id: FPLX:000174 name: FOXO synonym: "FOXO" EXACT [] synonym: "FoxO" EXACT [] @@ -2881,49 +2901,49 @@ xref: BEL:"FOXO Family" xref: IP:IPR032067 xref: NCIT:C118892 xref: SIGNOR:SIGNOR-PF27 -is_a: FPLX:root -inverse_is_a: HGNC:FOXO1 -inverse_is_a: HGNC:FOXO3 -inverse_is_a: HGNC:FOXO4 -inverse_is_a: HGNC:FOXO6 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:3819 ! FOXO1 +relationship: inverse_is_a HGNC:3821 ! FOXO3 +relationship: inverse_is_a HGNC:7139 ! FOXO4 +relationship: inverse_is_a HGNC:24814 ! FOXO6 [Term] -id: FPLX:FSH +id: FPLX:000175 name: FSH synonym: "follicle-stimulating hormone" EXACT [] synonym: "FSH" EXACT [] xref: BEL:"Follicle Stimulating Hormone Complex" xref: GO:0016914 xref: RE:R-HSA-378947 -is_a: FPLX:root -has_part: HGNC:CGA -has_part: HGNC:FSHB +is_a: FPLX:000000 ! famplex +relationship: has_part HGNC:1885 ! CGA +relationship: has_part HGNC:3964 ! FSHB [Term] -id: FPLX:FUT +id: FPLX:000176 name: FUT synonym: "Fucosyltransferase" EXACT [] synonym: "Fucosyltransferases" EXACT [] synonym: "fucosyltransferase" EXACT [] synonym: "fucosyltransferases" EXACT [] synonym: "FUT" EXACT [] -is_a: FPLX:Glycosyltransferase -inverse_is_a: HGNC:FUT1 -inverse_is_a: HGNC:FUT2 -inverse_is_a: HGNC:FUT3 -inverse_is_a: HGNC:FUT4 -inverse_is_a: HGNC:FUT5 -inverse_is_a: HGNC:FUT6 -inverse_is_a: HGNC:FUT7 -inverse_is_a: HGNC:FUT8 -inverse_is_a: HGNC:FUT9 -inverse_is_a: HGNC:FUT10 -inverse_is_a: HGNC:FUT11 -inverse_is_a: HGNC:POFUT1 -inverse_is_a: HGNC:POFUT2 - -[Term] -id: FPLX:FZD +is_a: FPLX:000198 ! Glycosyltransferase +relationship: inverse_is_a HGNC:4012 ! FUT1 +relationship: inverse_is_a HGNC:4013 ! FUT2 +relationship: inverse_is_a HGNC:4014 ! FUT3 +relationship: inverse_is_a HGNC:4015 ! FUT4 +relationship: inverse_is_a HGNC:4016 ! FUT5 +relationship: inverse_is_a HGNC:4017 ! FUT6 +relationship: inverse_is_a HGNC:4018 ! FUT7 +relationship: inverse_is_a HGNC:4019 ! FUT8 +relationship: inverse_is_a HGNC:4020 ! FUT9 +relationship: inverse_is_a HGNC:19234 ! FUT10 +relationship: inverse_is_a HGNC:19233 ! FUT11 +relationship: inverse_is_a HGNC:14988 ! POFUT1 +relationship: inverse_is_a HGNC:14683 ! POFUT2 + +[Term] +id: FPLX:000177 name: FZD synonym: "Fz" EXACT [] synonym: "FZD" EXACT [] @@ -2933,28 +2953,28 @@ xref: MEDSCAN:urn:agi-complex:prophash-047b61fab6d7e7445346cc84dafcb267 xref: XFAM:PF01534 xref: RE:R-HSA-517388 xref: SIGNOR:SIGNOR-PF11 -is_a: FPLX:root -inverse_is_a: HGNC:FZD1 -inverse_is_a: HGNC:FZD10 -inverse_is_a: HGNC:FZD2 -inverse_is_a: HGNC:FZD3 -inverse_is_a: HGNC:FZD4 -inverse_is_a: HGNC:FZD5 -inverse_is_a: HGNC:FZD6 -inverse_is_a: HGNC:FZD7 -inverse_is_a: HGNC:FZD8 -inverse_is_a: HGNC:FZD9 - -[Term] -id: FPLX:F_actin +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:4038 ! FZD1 +relationship: inverse_is_a HGNC:4039 ! FZD10 +relationship: inverse_is_a HGNC:4040 ! FZD2 +relationship: inverse_is_a HGNC:4041 ! FZD3 +relationship: inverse_is_a HGNC:4042 ! FZD4 +relationship: inverse_is_a HGNC:4043 ! FZD5 +relationship: inverse_is_a HGNC:4044 ! FZD6 +relationship: inverse_is_a HGNC:4045 ! FZD7 +relationship: inverse_is_a HGNC:4046 ! FZD8 +relationship: inverse_is_a HGNC:4047 ! FZD9 + +[Term] +id: FPLX:000178 name: F-actin synonym: "F-actin" EXACT [] xref: GO:0031941 xref: MEDSCAN:urn:agi-protfc:F-actin-binding%20protein -is_a: FPLX:Actin +is_a: FPLX:000009 ! Actin [Term] -id: FPLX:GABR +id: FPLX:000179 name: GABR synonym: "GABA receptor" EXACT [] synonym: "GABA receptors" EXACT [] @@ -2963,55 +2983,55 @@ synonym: "gamma-aminobutyric-acid A receptor" EXACT [] synonym: "γ-aminobutyric-acid A receptor" EXACT [] xref: BEL:"GABR Family" xref: GO:0004890 -is_a: FPLX:root -inverse_is_a: HGNC:GABRA1 -inverse_is_a: HGNC:GABRA2 -inverse_is_a: HGNC:GABRA3 -inverse_is_a: HGNC:GABRA4 -inverse_is_a: HGNC:GABRA5 -inverse_is_a: HGNC:GABRA6 -inverse_is_a: HGNC:GABRB1 -inverse_is_a: HGNC:GABRB2 -inverse_is_a: HGNC:GABRB3 -inverse_is_a: HGNC:GABRD -inverse_is_a: HGNC:GABRE -inverse_is_a: HGNC:GABRG1 -inverse_is_a: HGNC:GABRG2 -inverse_is_a: HGNC:GABRG3 -inverse_is_a: HGNC:GABRP -inverse_is_a: HGNC:GABRQ -inverse_is_a: HGNC:GABRR1 -inverse_is_a: HGNC:GABRR2 -inverse_is_a: HGNC:GABRR3 - -[Term] -id: FPLX:GALNT +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:4075 ! GABRA1 +relationship: inverse_is_a HGNC:4076 ! GABRA2 +relationship: inverse_is_a HGNC:4077 ! GABRA3 +relationship: inverse_is_a HGNC:4078 ! GABRA4 +relationship: inverse_is_a HGNC:4079 ! GABRA5 +relationship: inverse_is_a HGNC:4080 ! GABRA6 +relationship: inverse_is_a HGNC:4081 ! GABRB1 +relationship: inverse_is_a HGNC:4082 ! GABRB2 +relationship: inverse_is_a HGNC:4083 ! GABRB3 +relationship: inverse_is_a HGNC:4084 ! GABRD +relationship: inverse_is_a HGNC:4085 ! GABRE +relationship: inverse_is_a HGNC:4086 ! GABRG1 +relationship: inverse_is_a HGNC:4087 ! GABRG2 +relationship: inverse_is_a HGNC:4088 ! GABRG3 +relationship: inverse_is_a HGNC:4089 ! GABRP +relationship: inverse_is_a HGNC:14454 ! GABRQ +relationship: inverse_is_a HGNC:4090 ! GABRR1 +relationship: inverse_is_a HGNC:4091 ! GABRR2 +relationship: inverse_is_a HGNC:17969 ! GABRR3 + +[Term] +id: FPLX:000180 name: GALNT synonym: "GALNT" EXACT [] -is_a: FPLX:Glycosyltransferase -inverse_is_a: HGNC:GALNTL5 -inverse_is_a: HGNC:GALNTL6 -inverse_is_a: HGNC:GALNT1 -inverse_is_a: HGNC:GALNT2 -inverse_is_a: HGNC:GALNT3 -inverse_is_a: HGNC:GALNT4 -inverse_is_a: HGNC:GALNT5 -inverse_is_a: HGNC:GALNT6 -inverse_is_a: HGNC:GALNT7 -inverse_is_a: HGNC:GALNT8 -inverse_is_a: HGNC:GALNT9 -inverse_is_a: HGNC:GALNT10 -inverse_is_a: HGNC:GALNT11 -inverse_is_a: HGNC:GALNT12 -inverse_is_a: HGNC:GALNT13 -inverse_is_a: HGNC:GALNT14 -inverse_is_a: HGNC:GALNT15 -inverse_is_a: HGNC:GALNT16 -inverse_is_a: HGNC:GALNT18 -inverse_is_a: HGNC:GALNT17 - -[Term] -id: FPLX:Gamma_secretase +is_a: FPLX:000198 ! Glycosyltransferase +relationship: inverse_is_a HGNC:21725 ! GALNTL5 +relationship: inverse_is_a HGNC:33844 ! GALNTL6 +relationship: inverse_is_a HGNC:4123 ! GALNT1 +relationship: inverse_is_a HGNC:4124 ! GALNT2 +relationship: inverse_is_a HGNC:4125 ! GALNT3 +relationship: inverse_is_a HGNC:4126 ! GALNT4 +relationship: inverse_is_a HGNC:4127 ! GALNT5 +relationship: inverse_is_a HGNC:4128 ! GALNT6 +relationship: inverse_is_a HGNC:4129 ! GALNT7 +relationship: inverse_is_a HGNC:4130 ! GALNT8 +relationship: inverse_is_a HGNC:4131 ! GALNT9 +relationship: inverse_is_a HGNC:19873 ! GALNT10 +relationship: inverse_is_a HGNC:19875 ! GALNT11 +relationship: inverse_is_a HGNC:19877 ! GALNT12 +relationship: inverse_is_a HGNC:23242 ! GALNT13 +relationship: inverse_is_a HGNC:22946 ! GALNT14 +relationship: inverse_is_a HGNC:21531 ! GALNT15 +relationship: inverse_is_a HGNC:23233 ! GALNT16 +relationship: inverse_is_a HGNC:30488 ! GALNT18 +relationship: inverse_is_a HGNC:16347 ! GALNT17 + +[Term] +id: FPLX:000181 name: Gamma-secretase synonym: "gamma secretase" EXACT [] synonym: "gamma-secretase" EXACT [] @@ -3019,32 +3039,32 @@ synonym: "γ secretase" EXACT [] xref: BEL:"gamma Secretase Complex" xref: GO:0070765 xref: NCIT:C95114 -is_a: FPLX:root -has_part: HGNC:APH1A -has_part: HGNC:PSEN1 -has_part: HGNC:PSENEN +is_a: FPLX:000000 ! famplex +relationship: has_part HGNC:29509 ! APH1A +relationship: has_part HGNC:9508 ! PSEN1 +relationship: has_part HGNC:30100 ! PSENEN [Term] -id: FPLX:GAP +id: FPLX:000182 name: GAP synonym: "GAP" EXACT [] synonym: "GTPase-activating proteins" EXACT [] xref: GO:0005096 xref: NCIT:C17298 -is_a: FPLX:root +is_a: FPLX:000000 ! famplex [Term] -id: FPLX:GAS6_receptor +id: FPLX:000183 name: GAS6-receptor synonym: "Gas6 receptors" EXACT [] xref: BEL:"GAS6 Receptor Family" -is_a: FPLX:root -inverse_is_a: HGNC:AXL -inverse_is_a: HGNC:MERTK -inverse_is_a: HGNC:TYRO3 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:905 ! AXL +relationship: inverse_is_a HGNC:7027 ! MERTK +relationship: inverse_is_a HGNC:12446 ! TYRO3 [Term] -id: FPLX:GATA +id: FPLX:000184 name: GATA synonym: "GATA family" EXACT [] synonym: "GATA" EXACT [] @@ -3052,16 +3072,16 @@ xref: BEL:"GATA Family" xref: MEDSCAN:urn:agi-aopfc:0000105 xref: XFAM:PF00320 xref: RE:R-HSA-996770 -is_a: FPLX:root -inverse_is_a: HGNC:GATA1 -inverse_is_a: HGNC:GATA2 -inverse_is_a: HGNC:GATA3 -inverse_is_a: HGNC:GATA4 -inverse_is_a: HGNC:GATA5 -inverse_is_a: HGNC:GATA6 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:4170 ! GATA1 +relationship: inverse_is_a HGNC:4171 ! GATA2 +relationship: inverse_is_a HGNC:4172 ! GATA3 +relationship: inverse_is_a HGNC:4173 ! GATA4 +relationship: inverse_is_a HGNC:15802 ! GATA5 +relationship: inverse_is_a HGNC:4174 ! GATA6 [Term] -id: FPLX:GCNT +id: FPLX:000185 name: GCNT synonym: "GCNT" EXACT [] synonym: "XYLT" EXACT [] @@ -3069,26 +3089,26 @@ synonym: "Xylosyltransferase" EXACT [] synonym: "Xylosyltransferases" EXACT [] synonym: "xylosyltransferase" EXACT [] synonym: "xylosyltransferases" EXACT [] -is_a: FPLX:Glycosyltransferase -inverse_is_a: HGNC:GCNT1 -inverse_is_a: HGNC:GCNT2 -inverse_is_a: HGNC:GCNT3 -inverse_is_a: HGNC:GCNT4 -inverse_is_a: HGNC:GCNT7 -inverse_is_a: HGNC:XYLT1 -inverse_is_a: HGNC:XYLT2 +is_a: FPLX:000198 ! Glycosyltransferase +relationship: inverse_is_a HGNC:4203 ! GCNT1 +relationship: inverse_is_a HGNC:4204 ! GCNT2 +relationship: inverse_is_a HGNC:4205 ! GCNT3 +relationship: inverse_is_a HGNC:17973 ! GCNT4 +relationship: inverse_is_a HGNC:16099 ! GCNT7 +relationship: inverse_is_a HGNC:15516 ! XYLT1 +relationship: inverse_is_a HGNC:15517 ! XYLT2 [Term] -id: FPLX:GEF +id: FPLX:000186 name: GEF synonym: "GEF" EXACT [] synonym: "GEFs" EXACT [] xref: GO:0008433 xref: NCIT:C17494 -is_a: FPLX:root +is_a: FPLX:000000 ! famplex [Term] -id: FPLX:GPCR +id: FPLX:000187 name: GPCR synonym: "Class C GPCR" EXACT [] synonym: "GPCR" EXACT [] @@ -3098,10 +3118,10 @@ xref: MEDSCAN:urn:agi-complex:prophash-763d31b31e177311583df0ac1ea015da xref: MEDSCAN:urn:agi-protfc:class%20c%20orphan%20receptor xref: NCIT:C18239 xref: SIGNOR:SIGNOR-PF33 -is_a: FPLX:root +is_a: FPLX:000000 ! famplex [Term] -id: FPLX:GPIb_IX_V +id: FPLX:000188 name: GPIb-IX-V synonym: "glycoprotein Ib-V-IX complex" EXACT [] synonym: "Glycoprotein Ib-V-IX" EXACT [] @@ -3113,14 +3133,14 @@ xref: BEL:"Ib-V-IX Complex" xref: GO:1990779 xref: NCIT:C126122 xref: RE:R-HSA-114668 -is_a: FPLX:root -has_part: HGNC:GP1BA -has_part: HGNC:GP1BB -has_part: HGNC:GP5 -has_part: HGNC:GP9 +is_a: FPLX:000000 ! famplex +relationship: has_part HGNC:4439 ! GP1BA +relationship: has_part HGNC:4440 ! GP1BB +relationship: has_part HGNC:4443 ! GP5 +relationship: has_part HGNC:4444 ! GP9 [Term] -id: FPLX:GPIT +id: FPLX:000189 name: GPIT synonym: "glycosylphosphatidylinositol transamidase complex" EXACT [] synonym: "GPI transamidase complex" EXACT [] @@ -3128,15 +3148,15 @@ synonym: "GPIT complex" EXACT [] synonym: "GPIT" EXACT [] xref: BEL:"GPIT Complex" xref: RE:R-HSA-162690 -is_a: FPLX:root -has_part: HGNC:GPAA1 -has_part: HGNC:PIGK -has_part: HGNC:PIGS -has_part: HGNC:PIGT -has_part: HGNC:PIGU +is_a: FPLX:000000 ! famplex +relationship: has_part HGNC:4446 ! GPAA1 +relationship: has_part HGNC:8965 ! PIGK +relationship: has_part HGNC:14937 ! PIGS +relationship: has_part HGNC:14938 ! PIGT +relationship: has_part HGNC:15791 ! PIGU [Term] -id: FPLX:GPX +id: FPLX:000190 name: GPX synonym: "glutathione peroxidase" EXACT [] xref: BEL:"GPX Family" @@ -3145,18 +3165,18 @@ xref: IP:IPR000889 xref: IP:IPR029760 xref: NEXTPROT-FAMILY:01553 xref: XFAM:PF00255 -is_a: FPLX:root -inverse_is_a: HGNC:GPX1 -inverse_is_a: HGNC:GPX2 -inverse_is_a: HGNC:GPX3 -inverse_is_a: HGNC:GPX4 -inverse_is_a: HGNC:GPX5 -inverse_is_a: HGNC:GPX6 -inverse_is_a: HGNC:GPX7 -inverse_is_a: HGNC:GPX8 - -[Term] -id: FPLX:GRIA +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:4553 ! GPX1 +relationship: inverse_is_a HGNC:4554 ! GPX2 +relationship: inverse_is_a HGNC:4555 ! GPX3 +relationship: inverse_is_a HGNC:4556 ! GPX4 +relationship: inverse_is_a HGNC:4557 ! GPX5 +relationship: inverse_is_a HGNC:4558 ! GPX6 +relationship: inverse_is_a HGNC:4559 ! GPX7 +relationship: inverse_is_a HGNC:33100 ! GPX8 + +[Term] +id: FPLX:000191 name: GRIA synonym: "AMPA glutamate receptor" EXACT [] synonym: "AMPA receptor" EXACT [] @@ -3170,14 +3190,14 @@ xref: RE:R-HSA-399713 xref: RE:R-HSA-416323 xref: RE:R-HSA-420974 xref: RE:R-HSA-421001 -is_a: FPLX:root -inverse_is_a: HGNC:GRIA1 -inverse_is_a: HGNC:GRIA2 -inverse_is_a: HGNC:GRIA3 -inverse_is_a: HGNC:GRIA4 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:4571 ! GRIA1 +relationship: inverse_is_a HGNC:4572 ! GRIA2 +relationship: inverse_is_a HGNC:4573 ! GRIA3 +relationship: inverse_is_a HGNC:4574 ! GRIA4 [Term] -id: FPLX:GRK +id: FPLX:000192 name: GRK synonym: "G protein-coupled receptor kinases" EXACT [] synonym: "GPCR kinases" EXACT [] @@ -3187,16 +3207,16 @@ xref: BEL:"GRK Family" xref: ECCODE:2.7.11.16 xref: IP:IPR000239 xref: NCIT:C26233 -is_a: FPLX:root -inverse_is_a: FPLX:ADRBK -inverse_is_a: HGNC:GRK1 -inverse_is_a: HGNC:GRK4 -inverse_is_a: HGNC:GRK5 -inverse_is_a: HGNC:GRK6 -inverse_is_a: HGNC:GRK7 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a FPLX:000022 ! ADRBK +relationship: inverse_is_a HGNC:10013 ! GRK1 +relationship: inverse_is_a HGNC:4543 ! GRK4 +relationship: inverse_is_a HGNC:4544 ! GRK5 +relationship: inverse_is_a HGNC:4545 ! GRK6 +relationship: inverse_is_a HGNC:17031 ! GRK7 [Term] -id: FPLX:GRM +id: FPLX:000193 name: GRM synonym: "glutamate metabotropic receptors" EXACT [] synonym: "metabotrophic glutamate receptor" EXACT [] @@ -3207,18 +3227,18 @@ xref: IP:IPR000162 xref: MEDSCAN:urn:agi-protfc:mglur xref: RE:R-HSA-420516 xref: RE:R-HSA-420519 -is_a: FPLX:root -inverse_is_a: HGNC:GRM1 -inverse_is_a: HGNC:GRM2 -inverse_is_a: HGNC:GRM3 -inverse_is_a: HGNC:GRM4 -inverse_is_a: HGNC:GRM5 -inverse_is_a: HGNC:GRM6 -inverse_is_a: HGNC:GRM7 -inverse_is_a: HGNC:GRM8 - -[Term] -id: FPLX:GSK3 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:4593 ! GRM1 +relationship: inverse_is_a HGNC:4594 ! GRM2 +relationship: inverse_is_a HGNC:4595 ! GRM3 +relationship: inverse_is_a HGNC:4596 ! GRM4 +relationship: inverse_is_a HGNC:4597 ! GRM5 +relationship: inverse_is_a HGNC:4598 ! GRM6 +relationship: inverse_is_a HGNC:4599 ! GRM7 +relationship: inverse_is_a HGNC:4600 ! GRM8 + +[Term] +id: FPLX:000194 name: GSK3 synonym: "GSK-3" EXACT [] synonym: "GSK3" EXACT [] @@ -3227,12 +3247,12 @@ xref: MEDSCAN:urn:agi-aopfc:0000434 xref: NEXTPROT-FAMILY:03087 xref: RE:R-HSA-198358 xref: RE:R-HSA-198373 -is_a: FPLX:root -inverse_is_a: HGNC:GSK3A -inverse_is_a: HGNC:GSK3B +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:4616 ! GSK3A +relationship: inverse_is_a HGNC:4617 ! GSK3B [Term] -id: FPLX:GST +id: FPLX:000195 name: GST synonym: "glutathione S-transferase" EXACT [] synonym: "GST" EXACT [] @@ -3240,28 +3260,28 @@ synonym: "GSTs" EXACT [] xref: BEL:"GST Family" xref: NCIT:C16641 xref: NEXTPROT-FAMILY:01669 -is_a: FPLX:root -inverse_is_a: HGNC:GSTA1 -inverse_is_a: HGNC:GSTA2 -inverse_is_a: HGNC:GSTA3 -inverse_is_a: HGNC:GSTA4 -inverse_is_a: HGNC:GSTA5 -inverse_is_a: HGNC:GSTK1 -inverse_is_a: HGNC:GSTM1 -inverse_is_a: HGNC:GSTM2 -inverse_is_a: HGNC:GSTM3 -inverse_is_a: HGNC:GSTM4 -inverse_is_a: HGNC:GSTM5 -inverse_is_a: HGNC:GSTO1 -inverse_is_a: HGNC:GSTO2 -inverse_is_a: HGNC:GSTP1 -inverse_is_a: HGNC:GSTT1 -inverse_is_a: HGNC:GSTT2 -inverse_is_a: HGNC:GSTZ1 -inverse_is_a: HGNC:GSTT2B - -[Term] -id: FPLX:GTF2E +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:4626 ! GSTA1 +relationship: inverse_is_a HGNC:4627 ! GSTA2 +relationship: inverse_is_a HGNC:4628 ! GSTA3 +relationship: inverse_is_a HGNC:4629 ! GSTA4 +relationship: inverse_is_a HGNC:19662 ! GSTA5 +relationship: inverse_is_a HGNC:16906 ! GSTK1 +relationship: inverse_is_a HGNC:4632 ! GSTM1 +relationship: inverse_is_a HGNC:4634 ! GSTM2 +relationship: inverse_is_a HGNC:4635 ! GSTM3 +relationship: inverse_is_a HGNC:4636 ! GSTM4 +relationship: inverse_is_a HGNC:4637 ! GSTM5 +relationship: inverse_is_a HGNC:13312 ! GSTO1 +relationship: inverse_is_a HGNC:23064 ! GSTO2 +relationship: inverse_is_a HGNC:4638 ! GSTP1 +relationship: inverse_is_a HGNC:4641 ! GSTT1 +relationship: inverse_is_a HGNC:4642 ! GSTT2 +relationship: inverse_is_a HGNC:4643 ! GSTZ1 +relationship: inverse_is_a HGNC:33437 ! GSTT2B + +[Term] +id: FPLX:000196 name: GTF2E synonym: "general transcription factor II E" EXACT [] synonym: "TFIIE" EXACT [] @@ -3270,12 +3290,12 @@ synonym: "transcription factor IIE" EXACT [] xref: BEL:"GTF2E Complex" xref: GO:0005673 xref: RE:R-HSA-109633 -is_a: FPLX:root -has_part: HGNC:GTF2E1 -has_part: HGNC:GTF2E2 +is_a: FPLX:000000 ! famplex +relationship: has_part HGNC:4650 ! GTF2E1 +relationship: has_part HGNC:4651 ! GTF2E2 [Term] -id: FPLX:GTF2F +id: FPLX:000197 name: GTF2F synonym: "general transcription factor II F" EXACT [] synonym: "TFIIF" EXACT [] @@ -3285,84 +3305,84 @@ xref: BEL:"GTF2F Complex" xref: GO:0005674 xref: IP:IPR011039 xref: RE:R-HSA-109631 -is_a: FPLX:root -has_part: HGNC:GTF2F1 -has_part: HGNC:GTF2F2 +is_a: FPLX:000000 ! famplex +relationship: has_part HGNC:4652 ! GTF2F1 +relationship: has_part HGNC:4653 ! GTF2F2 [Term] -id: FPLX:Glycosyltransferase +id: FPLX:000198 name: Glycosyltransferase xref: MESH:D016695 -is_a: FPLX:root -inverse_is_a: FPLX:A4GALT_family -inverse_is_a: FPLX:ALG10 -inverse_is_a: FPLX:ALG1_family -inverse_is_a: FPLX:ALG3_family -inverse_is_a: FPLX:ALG6_family -inverse_is_a: FPLX:ALG13_family -inverse_is_a: FPLX:B3GAT -inverse_is_a: FPLX:Beta_3_4_GTF -inverse_is_a: FPLX:COLGALT -inverse_is_a: FPLX:EXT -inverse_is_a: FPLX:FUT -inverse_is_a: FPLX:GALNT -inverse_is_a: FPLX:GCNT -inverse_is_a: FPLX:GTF_family_2 -inverse_is_a: FPLX:GTF_family_6 -inverse_is_a: FPLX:GTF_family_8 -inverse_is_a: FPLX:GTF_family_29 -inverse_is_a: FPLX:GTF_family_90 -inverse_is_a: FPLX:MGAT -inverse_is_a: FPLX:OGT_family -inverse_is_a: FPLX:PYG -inverse_is_a: FPLX:STT3 -inverse_is_a: FPLX:UGCG -inverse_is_a: FPLX:UGT -inverse_is_a: FPLX:UGGT - -[Term] -id: FPLX:GTF_family_2 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a FPLX:000002 ! A4GALT_family +relationship: inverse_is_a FPLX:000026 ! ALG10 +relationship: inverse_is_a FPLX:000027 ! ALG1_family +relationship: inverse_is_a FPLX:000028 ! ALG3_family +relationship: inverse_is_a FPLX:000029 ! ALG6_family +relationship: inverse_is_a FPLX:000030 ! ALG13_family +relationship: inverse_is_a FPLX:000063 ! B3GAT +relationship: inverse_is_a FPLX:000065 ! Beta_3_4_GTF +relationship: inverse_is_a FPLX:000112 ! COLGALT +relationship: inverse_is_a FPLX:000165 ! EXT +relationship: inverse_is_a FPLX:000176 ! FUT +relationship: inverse_is_a FPLX:000180 ! GALNT +relationship: inverse_is_a FPLX:000185 ! GCNT +relationship: inverse_is_a FPLX:000199 ! GTF_family_2 +relationship: inverse_is_a FPLX:000200 ! GTF_family_6 +relationship: inverse_is_a FPLX:000201 ! GTF_family_8 +relationship: inverse_is_a FPLX:000202 ! GTF_family_29 +relationship: inverse_is_a FPLX:000203 ! GTF_family_90 +relationship: inverse_is_a FPLX:000287 ! MGAT +relationship: inverse_is_a FPLX:000322 ! OGT_family +relationship: inverse_is_a FPLX:000396 ! PYG +relationship: inverse_is_a FPLX:000455 ! STT3 +relationship: inverse_is_a FPLX:000491 ! UGCG +relationship: inverse_is_a FPLX:000492 ! UGT +relationship: inverse_is_a FPLX:000493 ! UGGT + +[Term] +id: FPLX:000199 name: GTF-family-2 synonym: "Glycosyltransferase family 2" EXACT [] synonym: "glycosyltransferase family 2" EXACT [] -is_a: FPLX:Glycosyltransferase -inverse_is_a: HGNC:ALG5 -inverse_is_a: HGNC:B3GNTL1 -inverse_is_a: HGNC:DPM1 -inverse_is_a: HGNC:HAS1 -inverse_is_a: HGNC:HAS2 -inverse_is_a: HGNC:HAS3 +is_a: FPLX:000198 ! Glycosyltransferase +relationship: inverse_is_a HGNC:20266 ! ALG5 +relationship: inverse_is_a HGNC:21727 ! B3GNTL1 +relationship: inverse_is_a HGNC:3005 ! DPM1 +relationship: inverse_is_a HGNC:4818 ! HAS1 +relationship: inverse_is_a HGNC:4819 ! HAS2 +relationship: inverse_is_a HGNC:4820 ! HAS3 [Term] -id: FPLX:GTF_family_6 +id: FPLX:000200 name: GTF-family-6 synonym: "Glycosyltransferase family 6" EXACT [] synonym: "glycosyltransferase family 6" EXACT [] -is_a: FPLX:Glycosyltransferase -inverse_is_a: HGNC:ABO -inverse_is_a: HGNC:A3GALT2 -inverse_is_a: HGNC:GBGT1 -inverse_is_a: HGNC:GLT6D1 +is_a: FPLX:000198 ! Glycosyltransferase +relationship: inverse_is_a HGNC:79 ! ABO +relationship: inverse_is_a HGNC:30005 ! A3GALT2 +relationship: inverse_is_a HGNC:20460 ! GBGT1 +relationship: inverse_is_a HGNC:23671 ! GLT6D1 [Term] -id: FPLX:GTF_family_8 +id: FPLX:000201 name: GTF-family-8 synonym: "Glycosyltransferase family 8" EXACT [] synonym: "glycosyltransferase family 8" EXACT [] -is_a: FPLX:Glycosyltransferase -inverse_is_a: HGNC:GLT8D1 -inverse_is_a: HGNC:GLT8D2 -inverse_is_a: HGNC:GXYLT1 -inverse_is_a: HGNC:GXYLT2 -inverse_is_a: HGNC:GYG1 -inverse_is_a: HGNC:GYG2 -inverse_is_a: HGNC:LARGE1 -inverse_is_a: HGNC:LARGE2 -inverse_is_a: HGNC:RXYLT1 -inverse_is_a: HGNC:XXYLT1 - -[Term] -id: FPLX:GTF_family_29 +is_a: FPLX:000198 ! Glycosyltransferase +relationship: inverse_is_a HGNC:24870 ! GLT8D1 +relationship: inverse_is_a HGNC:24890 ! GLT8D2 +relationship: inverse_is_a HGNC:27482 ! GXYLT1 +relationship: inverse_is_a HGNC:33383 ! GXYLT2 +relationship: inverse_is_a HGNC:4699 ! GYG1 +relationship: inverse_is_a HGNC:4700 ! GYG2 +relationship: inverse_is_a HGNC:6511 ! LARGE1 +relationship: inverse_is_a HGNC:16522 ! LARGE2 +relationship: inverse_is_a HGNC:13530 ! RXYLT1 +relationship: inverse_is_a HGNC:26639 ! XXYLT1 + +[Term] +id: FPLX:000202 name: GTF-family-29 synonym: "Glycosyltransferase family 29" EXACT [] synonym: "glycosyltransferase family 29" EXACT [] @@ -3370,74 +3390,74 @@ synonym: "Sialytransferase" EXACT [] synonym: "Sialytransferases" EXACT [] synonym: "sialytransferase" EXACT [] synonym: "sialytransferases" EXACT [] -is_a: FPLX:Glycosyltransferase -inverse_is_a: HGNC:ST3GAL1 -inverse_is_a: HGNC:ST3GAL2 -inverse_is_a: HGNC:ST3GAL3 -inverse_is_a: HGNC:ST3GAL4 -inverse_is_a: HGNC:ST3GAL5 -inverse_is_a: HGNC:ST3GAL6 -inverse_is_a: HGNC:ST6GALNAC1 -inverse_is_a: HGNC:ST6GALNAC2 -inverse_is_a: HGNC:ST6GALNAC3 -inverse_is_a: HGNC:ST6GALNAC4 -inverse_is_a: HGNC:ST6GALNAC5 -inverse_is_a: HGNC:ST6GALNAC6 -inverse_is_a: HGNC:ST6GAL1 -inverse_is_a: HGNC:ST6GAL2 -inverse_is_a: HGNC:ST8SIA1 -inverse_is_a: HGNC:ST8SIA2 -inverse_is_a: HGNC:ST8SIA3 -inverse_is_a: HGNC:ST8SIA4 -inverse_is_a: HGNC:ST8SIA5 -inverse_is_a: HGNC:ST8SIA6 - -[Term] -id: FPLX:GTF_family_90 +is_a: FPLX:000198 ! Glycosyltransferase +relationship: inverse_is_a HGNC:10862 ! ST3GAL1 +relationship: inverse_is_a HGNC:10863 ! ST3GAL2 +relationship: inverse_is_a HGNC:10866 ! ST3GAL3 +relationship: inverse_is_a HGNC:10864 ! ST3GAL4 +relationship: inverse_is_a HGNC:10872 ! ST3GAL5 +relationship: inverse_is_a HGNC:18080 ! ST3GAL6 +relationship: inverse_is_a HGNC:23614 ! ST6GALNAC1 +relationship: inverse_is_a HGNC:10867 ! ST6GALNAC2 +relationship: inverse_is_a HGNC:19343 ! ST6GALNAC3 +relationship: inverse_is_a HGNC:17846 ! ST6GALNAC4 +relationship: inverse_is_a HGNC:19342 ! ST6GALNAC5 +relationship: inverse_is_a HGNC:23364 ! ST6GALNAC6 +relationship: inverse_is_a HGNC:10860 ! ST6GAL1 +relationship: inverse_is_a HGNC:10861 ! ST6GAL2 +relationship: inverse_is_a HGNC:10869 ! ST8SIA1 +relationship: inverse_is_a HGNC:10870 ! ST8SIA2 +relationship: inverse_is_a HGNC:14269 ! ST8SIA3 +relationship: inverse_is_a HGNC:10871 ! ST8SIA4 +relationship: inverse_is_a HGNC:17827 ! ST8SIA5 +relationship: inverse_is_a HGNC:23317 ! ST8SIA6 + +[Term] +id: FPLX:000203 name: GTF-family-90 synonym: "Glycosyltransferase family 90" EXACT [] synonym: "glycosyltransferase family 90" EXACT [] -is_a: FPLX:Glycosyltransferase -inverse_is_a: HGNC:POGLUT2 -inverse_is_a: HGNC:POGLUT3 -inverse_is_a: HGNC:POGLUT1 +is_a: FPLX:000198 ! Glycosyltransferase +relationship: inverse_is_a HGNC:19350 ! POGLUT2 +relationship: inverse_is_a HGNC:28496 ! POGLUT3 +relationship: inverse_is_a HGNC:22954 ! POGLUT1 [Term] -id: FPLX:GTPase +id: FPLX:000204 name: GTPase synonym: "GTPase" EXACT [] xref: ECCODE:3.6.5.- xref: MEDSCAN:urn:agi-complex:prophash-e9fbfd73e486bda4d99b348f72bb4196 xref: NCIT:C16650 -is_a: FPLX:root +is_a: FPLX:000000 ! famplex [Term] -id: FPLX:GUCY +id: FPLX:000205 name: GUCY synonym: "guanylate cyclase" EXACT [] synonym: "guanylyl cyclase" EXACT [] xref: BEL:"GUCY Family" xref: ECCODE:4.6.1.2 xref: NCIT:C16653 -is_a: FPLX:root -inverse_is_a: HGNC:GUCY2C -inverse_is_a: HGNC:GUCY2D -inverse_is_a: HGNC:GUCY2F -inverse_is_a: HGNC:NPR1 -inverse_is_a: HGNC:NPR2 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:4688 ! GUCY2C +relationship: inverse_is_a HGNC:4689 ! GUCY2D +relationship: inverse_is_a HGNC:4691 ! GUCY2F +relationship: inverse_is_a HGNC:7943 ! NPR1 +relationship: inverse_is_a HGNC:7944 ! NPR2 [Term] -id: FPLX:GYS +id: FPLX:000206 name: GYS synonym: "glycogen synthase" EXACT [] xref: BEL:"GYS Family" xref: IP:IPR008631 -is_a: FPLX:root -inverse_is_a: HGNC:GYS1 -inverse_is_a: HGNC:GYS2 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:4706 ! GYS1 +relationship: inverse_is_a HGNC:4707 ! GYS2 [Term] -id: FPLX:G_12 +id: FPLX:000207 name: G-12 synonym: "G(12)" EXACT [] synonym: "G12 family" EXACT [] @@ -3447,11 +3467,11 @@ xref: IP:IPR000469 xref: RE:R-HSA-114547 xref: RE:R-HSA-418570 xref: RE:R-HSA-418572 -is_a: FPLX:G_protein -has_part: FPLX:G_12_alpha +is_a: FPLX:000214 ! G_protein +relationship: has_part FPLX:000208 ! G_12_alpha [Term] -id: FPLX:G_12_alpha +id: FPLX:000208 name: G-12-alpha synonym: "G-protein alpha-12" EXACT [] synonym: "G-protein α-12" EXACT [] @@ -3462,25 +3482,25 @@ xref: IP:IPR000469 xref: RE:R-HSA-114525 xref: RE:R-HSA-418570 xref: RE:R-HSA-418572 -is_a: FPLX:G_alpha -part_of: FPLX:G_12 -inverse_is_a: HGNC:GNA12 -inverse_is_a: HGNC:GNA13 +is_a: FPLX:000209 ! G_alpha +relationship: part_of FPLX:000207 ! G_12 +relationship: inverse_is_a HGNC:4380 ! GNA12 +relationship: inverse_is_a HGNC:4381 ! GNA13 [Term] -id: FPLX:G_alpha +id: FPLX:000209 name: G-alpha synonym: "G_alpha" EXACT [] synonym: "G_α" EXACT [] xref: XFAM:PF00503 -is_a: FPLX:root -inverse_is_a: FPLX:G_i_alpha -inverse_is_a: FPLX:G_s_alpha -inverse_is_a: FPLX:G_q_alpha -inverse_is_a: FPLX:G_12_alpha +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a FPLX:000213 ! G_i_alpha +relationship: inverse_is_a FPLX:000218 ! G_s_alpha +relationship: inverse_is_a FPLX:000216 ! G_q_alpha +relationship: inverse_is_a FPLX:000208 ! G_12_alpha [Term] -id: FPLX:G_beta +id: FPLX:000210 name: G-beta synonym: "G protein beta" EXACT [] synonym: "G protein β" EXACT [] @@ -3496,15 +3516,15 @@ xref: RE:R-HSA-6814207 xref: RE:R-HSA-6814413 xref: RE:R-HSA-8850524 xref: SIGNOR:SIGNOR-PF4 -is_a: FPLX:root -inverse_is_a: HGNC:GNB1 -inverse_is_a: HGNC:GNB2 -inverse_is_a: HGNC:GNB3 -inverse_is_a: HGNC:GNB4 -inverse_is_a: HGNC:GNB5 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:4396 ! GNB1 +relationship: inverse_is_a HGNC:4398 ! GNB2 +relationship: inverse_is_a HGNC:4400 ! GNB3 +relationship: inverse_is_a HGNC:20731 ! GNB4 +relationship: inverse_is_a HGNC:4401 ! GNB5 [Term] -id: FPLX:G_gamma +id: FPLX:000211 name: G-gamma synonym: "G protein gamma subunit" EXACT [] synonym: "G protein gamma" EXACT [] @@ -3516,22 +3536,22 @@ xref: NEXTPROT-FAMILY:01400 xref: RE:R-HSA-167442 xref: RE:R-HSA-400062 xref: SIGNOR:SIGNOR-PF3 -is_a: FPLX:root -inverse_is_a: HGNC:GNG10 -inverse_is_a: HGNC:GNG11 -inverse_is_a: HGNC:GNG12 -inverse_is_a: HGNC:GNG13 -inverse_is_a: HGNC:GNG2 -inverse_is_a: HGNC:GNG3 -inverse_is_a: HGNC:GNG4 -inverse_is_a: HGNC:GNG5 -inverse_is_a: HGNC:GNG7 -inverse_is_a: HGNC:GNG8 -inverse_is_a: HGNC:GNGT1 -inverse_is_a: HGNC:GNGT2 - -[Term] -id: FPLX:G_i +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:4402 ! GNG10 +relationship: inverse_is_a HGNC:4403 ! GNG11 +relationship: inverse_is_a HGNC:19663 ! GNG12 +relationship: inverse_is_a HGNC:14131 ! GNG13 +relationship: inverse_is_a HGNC:4404 ! GNG2 +relationship: inverse_is_a HGNC:4405 ! GNG3 +relationship: inverse_is_a HGNC:4407 ! GNG4 +relationship: inverse_is_a HGNC:4408 ! GNG5 +relationship: inverse_is_a HGNC:4410 ! GNG7 +relationship: inverse_is_a HGNC:19664 ! GNG8 +relationship: inverse_is_a HGNC:4411 ! GNGT1 +relationship: inverse_is_a HGNC:4412 ! GNGT2 + +[Term] +id: FPLX:000212 name: G-i synonym: "Gi protein" EXACT [] synonym: "Gi" EXACT [] @@ -3541,11 +3561,11 @@ xref: RE:R-HSA-111864 xref: RE:R-HSA-167410 xref: RE:R-HSA-167413 xref: RE:R-HSA-167438 -is_a: FPLX:G_protein -has_part: FPLX:G_i_alpha +is_a: FPLX:000214 ! G_protein +relationship: has_part FPLX:000213 ! G_i_alpha [Term] -id: FPLX:G_i_alpha +id: FPLX:000213 name: G-i-alpha synonym: "G alphai" EXACT [] synonym: "G αi" EXACT [] @@ -3563,31 +3583,31 @@ xref: RE:R-HSA-111864 xref: RE:R-HSA-167410 xref: RE:R-HSA-167413 xref: RE:R-HSA-167438 -is_a: FPLX:G_alpha -part_of: FPLX:G_i -inverse_is_a: HGNC:GNAO1 -inverse_is_a: HGNC:GNAI1 -inverse_is_a: HGNC:GNAI2 -inverse_is_a: HGNC:GNAI3 -inverse_is_a: HGNC:GNAT1 -inverse_is_a: HGNC:GNAT2 -inverse_is_a: HGNC:GNAT3 -inverse_is_a: HGNC:GNAZ - -[Term] -id: FPLX:G_protein +is_a: FPLX:000209 ! G_alpha +relationship: part_of FPLX:000212 ! G_i +relationship: inverse_is_a HGNC:4389 ! GNAO1 +relationship: inverse_is_a HGNC:4384 ! GNAI1 +relationship: inverse_is_a HGNC:4385 ! GNAI2 +relationship: inverse_is_a HGNC:4387 ! GNAI3 +relationship: inverse_is_a HGNC:4393 ! GNAT1 +relationship: inverse_is_a HGNC:4394 ! GNAT2 +relationship: inverse_is_a HGNC:22800 ! GNAT3 +relationship: inverse_is_a HGNC:4395 ! GNAZ + +[Term] +id: FPLX:000214 name: G-protein synonym: "G protein" EXACT [] synonym: "G proteins" EXACT [] xref: NCIT:C17458 -is_a: FPLX:root -inverse_is_a: FPLX:G_i -inverse_is_a: FPLX:G_s -inverse_is_a: FPLX:G_q -inverse_is_a: FPLX:G_12 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a FPLX:000212 ! G_i +relationship: inverse_is_a FPLX:000217 ! G_s +relationship: inverse_is_a FPLX:000215 ! G_q +relationship: inverse_is_a FPLX:000207 ! G_12 [Term] -id: FPLX:G_q +id: FPLX:000215 name: G-q synonym: "G(q/11)" EXACT [] synonym: "Gq/11" EXACT [] @@ -3601,11 +3621,11 @@ xref: RE:R-HSA-399992 xref: RE:R-HSA-400000 xref: RE:R-HSA-400008 xref: RE:R-HSA-749499 -is_a: FPLX:G_protein -has_part: FPLX:G_q_alpha +is_a: FPLX:000214 ! G_protein +relationship: has_part FPLX:000216 ! G_q_alpha [Term] -id: FPLX:G_q_alpha +id: FPLX:000216 name: G-q-alpha synonym: "G alphaq" EXACT [] synonym: "G αq" EXACT [] @@ -3626,15 +3646,15 @@ xref: RE:R-HSA-399992 xref: RE:R-HSA-400000 xref: RE:R-HSA-400008 xref: RE:R-HSA-749499 -is_a: FPLX:G_alpha -part_of: FPLX:G_q -inverse_is_a: HGNC:GNAQ -inverse_is_a: HGNC:GNA11 -inverse_is_a: HGNC:GNA14 -inverse_is_a: HGNC:GNA15 +is_a: FPLX:000209 ! G_alpha +relationship: part_of FPLX:000215 ! G_q +relationship: inverse_is_a HGNC:4390 ! GNAQ +relationship: inverse_is_a HGNC:4379 ! GNA11 +relationship: inverse_is_a HGNC:4382 ! GNA14 +relationship: inverse_is_a HGNC:4383 ! GNA15 [Term] -id: FPLX:G_s +id: FPLX:000217 name: G-s synonym: "G protein Gs" EXACT [] synonym: "G protein(s)" EXACT [] @@ -3642,11 +3662,11 @@ synonym: "G S protein" EXACT [] synonym: "Gs family" EXACT [] synonym: "Gs protein" EXACT [] xref: BEL:"GNA Gs Family" -is_a: FPLX:G_protein -has_part: FPLX:G_s_alpha +is_a: FPLX:000214 ! G_protein +relationship: has_part FPLX:000218 ! G_s_alpha [Term] -id: FPLX:G_s_alpha +id: FPLX:000218 name: G-s-alpha synonym: "G alphaS" EXACT [] synonym: "G αS" EXACT [] @@ -3662,23 +3682,23 @@ synonym: "Gs alpha" EXACT [] synonym: "Gs α subunit" EXACT [] synonym: "Gs α" EXACT [] synonym: "GαS" EXACT [] -is_a: FPLX:G_alpha -part_of: FPLX:G_s -inverse_is_a: HGNC:GNAS -inverse_is_a: HGNC:GNAL +is_a: FPLX:000209 ! G_alpha +relationship: part_of FPLX:000217 ! G_s +relationship: inverse_is_a HGNC:4392 ! GNAS +relationship: inverse_is_a HGNC:4388 ! GNAL [Term] -id: FPLX:hCG +id: FPLX:000219 name: hCG synonym: "hCG" EXACT [] xref: NCIT:C2275 xref: RE:R-HSA-378941 -is_a: FPLX:root -has_part: HGNC:CGA -has_part: HGNC:CGB3 +is_a: FPLX:000000 ! famplex +relationship: has_part HGNC:1885 ! CGA +relationship: has_part HGNC:1886 ! CGB3 [Term] -id: FPLX:HDAC +id: FPLX:000220 name: HDAC synonym: "HDAC" EXACT [] synonym: "histone deacetylase" EXACT [] @@ -3688,83 +3708,83 @@ xref: ECCODE:3.5.1.98 xref: IP:IPR003084 xref: MEDSCAN:urn:agi-complex:prophash-7e8823afb9ca7870b95633dcb782500b xref: NCIT:C16682 -is_a: FPLX:root -inverse_is_a: FPLX:HDAC_I -inverse_is_a: FPLX:HDAC_II -inverse_is_a: FPLX:HDAC_III -inverse_is_a: FPLX:HDAC_IV +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a FPLX:000221 ! HDAC_I +relationship: inverse_is_a FPLX:000222 ! HDAC_II +relationship: inverse_is_a FPLX:000223 ! HDAC_III +relationship: inverse_is_a FPLX:000224 ! HDAC_IV [Term] -id: FPLX:HDAC_I +id: FPLX:000221 name: HDAC-I synonym: "Class I HDACs" EXACT [] synonym: "class I HDACs" EXACT [] synonym: "class I histone deacetylases" EXACT [] xref: BEL:"HDAC Class I Family" xref: IP:IPR003084 -is_a: FPLX:HDAC -inverse_is_a: HGNC:HDAC1 -inverse_is_a: HGNC:HDAC2 -inverse_is_a: HGNC:HDAC3 -inverse_is_a: HGNC:HDAC8 +is_a: FPLX:000220 ! HDAC +relationship: inverse_is_a HGNC:4852 ! HDAC1 +relationship: inverse_is_a HGNC:4853 ! HDAC2 +relationship: inverse_is_a HGNC:4854 ! HDAC3 +relationship: inverse_is_a HGNC:13315 ! HDAC8 [Term] -id: FPLX:HDAC_II +id: FPLX:000222 name: HDAC-II synonym: "class II HDACs" EXACT [] synonym: "class II histone deacetylases" EXACT [] xref: BEL:"HDAC Class II Family" -is_a: FPLX:HDAC -inverse_is_a: HGNC:HDAC4 -inverse_is_a: HGNC:HDAC5 -inverse_is_a: HGNC:HDAC7 -inverse_is_a: HGNC:HDAC9 -inverse_is_a: HGNC:HDAC6 -inverse_is_a: HGNC:HDAC10 +is_a: FPLX:000220 ! HDAC +relationship: inverse_is_a HGNC:14063 ! HDAC4 +relationship: inverse_is_a HGNC:14068 ! HDAC5 +relationship: inverse_is_a HGNC:14067 ! HDAC7 +relationship: inverse_is_a HGNC:14065 ! HDAC9 +relationship: inverse_is_a HGNC:14064 ! HDAC6 +relationship: inverse_is_a HGNC:18128 ! HDAC10 [Term] -id: FPLX:HDAC_III +id: FPLX:000223 name: HDAC-III synonym: "Class III HDACs" EXACT [] synonym: "class III HDACs" EXACT [] synonym: "class III histone deacetylases" EXACT [] xref: IP:IPR003000 xref: IP:IPR026590 -is_a: FPLX:HDAC -inverse_is_a: HGNC:SIRT1 -inverse_is_a: HGNC:SIRT2 -inverse_is_a: HGNC:SIRT3 -inverse_is_a: HGNC:SIRT4 -inverse_is_a: HGNC:SIRT5 -inverse_is_a: HGNC:SIRT6 -inverse_is_a: HGNC:SIRT7 +is_a: FPLX:000220 ! HDAC +relationship: inverse_is_a HGNC:14929 ! SIRT1 +relationship: inverse_is_a HGNC:10886 ! SIRT2 +relationship: inverse_is_a HGNC:14931 ! SIRT3 +relationship: inverse_is_a HGNC:14932 ! SIRT4 +relationship: inverse_is_a HGNC:14933 ! SIRT5 +relationship: inverse_is_a HGNC:14934 ! SIRT6 +relationship: inverse_is_a HGNC:14935 ! SIRT7 [Term] -id: FPLX:HDAC_IV +id: FPLX:000224 name: HDAC-IV synonym: "Class IV HDACs" EXACT [] synonym: "class IV HDACs" EXACT [] synonym: "class IV histone deacetylases" EXACT [] -is_a: FPLX:HDAC -inverse_is_a: HGNC:HDAC11 +is_a: FPLX:000220 ! HDAC +relationship: inverse_is_a HGNC:19086 ! HDAC11 [Term] -id: FPLX:HDL +id: FPLX:000225 name: HDL synonym: "HDL" EXACT [] synonym: "High-density lipoproteins" EXACT [] xref: BEL:"HDL Complex" xref: GO:0034364 xref: NCIT:C25186 -is_a: FPLX:root -has_part: HGNC:ALB -has_part: HGNC:APOA1 -has_part: HGNC:APOA2 -has_part: HGNC:APOE -has_part: HGNC:CLU +is_a: FPLX:000000 ! famplex +relationship: has_part HGNC:399 ! ALB +relationship: has_part HGNC:600 ! APOA1 +relationship: has_part HGNC:601 ! APOA2 +relationship: has_part HGNC:613 ! APOE +relationship: has_part HGNC:2095 ! CLU [Term] -id: FPLX:Hedgehog +id: FPLX:000226 name: Hedgehog synonym: "Hedgehog family" EXACT [] synonym: "hedgehog protein" EXACT [] @@ -3787,99 +3807,99 @@ xref: RE:R-HSA-5358318 xref: RE:R-HSA-5358332 xref: RE:R-HSA-5362382 xref: RE:R-HSA-5362391 -is_a: FPLX:root -inverse_is_a: HGNC:DHH -inverse_is_a: HGNC:IHH -inverse_is_a: HGNC:SHH +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:2865 ! DHH +relationship: inverse_is_a HGNC:5956 ! IHH +relationship: inverse_is_a HGNC:10848 ! SHH [Term] -id: FPLX:Hemoglobin +id: FPLX:000227 name: Hemoglobin synonym: "hemoglobin" EXACT [] xref: BEL:"Hemoglobin Complex" xref: MEDSCAN:urn:agi-protfc:hemoglobin xref: NCIT:C16676 -is_a: FPLX:root -has_part: HGNC:HBA1 -has_part: HGNC:HBA2 -has_part: HGNC:HBB -has_part: HGNC:HBD -has_part: HGNC:HBE1 -has_part: HGNC:HBG1 -has_part: HGNC:HBG2 -has_part: HGNC:HBM -has_part: HGNC:HBQ1 -has_part: HGNC:HBZ - -[Term] -id: FPLX:HES +is_a: FPLX:000000 ! famplex +relationship: has_part HGNC:4823 ! HBA1 +relationship: has_part HGNC:4824 ! HBA2 +relationship: has_part HGNC:4827 ! HBB +relationship: has_part HGNC:4829 ! HBD +relationship: has_part HGNC:4830 ! HBE1 +relationship: has_part HGNC:4831 ! HBG1 +relationship: has_part HGNC:4832 ! HBG2 +relationship: has_part HGNC:4826 ! HBM +relationship: has_part HGNC:4833 ! HBQ1 +relationship: has_part HGNC:4835 ! HBZ + +[Term] +id: FPLX:000228 name: HES synonym: "Hes gene family" EXACT [] synonym: "Hes genes" EXACT [] synonym: "HES" EXACT [] synonym: "Hes" EXACT [] xref: BEL:"HES Family" -is_a: FPLX:root -inverse_is_a: HGNC:HES1 -inverse_is_a: HGNC:HES2 -inverse_is_a: HGNC:HES3 -inverse_is_a: HGNC:HES4 -inverse_is_a: HGNC:HES5 -inverse_is_a: HGNC:HES6 -inverse_is_a: HGNC:HES7 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:5192 ! HES1 +relationship: inverse_is_a HGNC:16005 ! HES2 +relationship: inverse_is_a HGNC:26226 ! HES3 +relationship: inverse_is_a HGNC:24149 ! HES4 +relationship: inverse_is_a HGNC:19764 ! HES5 +relationship: inverse_is_a HGNC:18254 ! HES6 +relationship: inverse_is_a HGNC:15977 ! HES7 [Term] -id: FPLX:HIF +id: FPLX:000229 name: HIF synonym: "HIF" EXACT [] synonym: "HIFs" EXACT [] synonym: "hypoxia-inducible factors" EXACT [] xref: NCIT:C113839 xref: RE:R-HSA-1234130 -is_a: FPLX:root -has_part: FPLX:HIF_alpha -has_part: FPLX:HIF_beta +is_a: FPLX:000000 ! famplex +relationship: has_part FPLX:000231 ! HIF_alpha +relationship: has_part FPLX:000232 ! HIF_beta [Term] -id: FPLX:HIF1 +id: FPLX:000230 name: HIF1 synonym: "HIF-1" EXACT [] xref: MEDSCAN:urn:agi-complex:HIF-1 xref: MEDSCAN:urn:agi-complex:prophash-44f61960049704dc2afb23ff7c324b85 xref: NCIT:C17690 xref: XFAM:PF11413 -is_a: FPLX:root -has_part: HGNC:HIF1A -has_part: HGNC:ARNT +is_a: FPLX:000000 ! famplex +relationship: has_part HGNC:4910 ! HIF1A +relationship: has_part HGNC:700 ! ARNT [Term] -id: FPLX:HIF_alpha +id: FPLX:000231 name: HIF-alpha synonym: "HIFalpha" EXACT [] synonym: "Hifalpha" EXACT [] synonym: "HIFα" EXACT [] synonym: "Hifα" EXACT [] xref: RE:R-HSA-1234147 -part_of: FPLX:HIF -inverse_is_a: HGNC:HIF1A -inverse_is_a: HGNC:EPAS1 -inverse_is_a: HGNC:HIF3A +relationship: part_of FPLX:000229 ! HIF +relationship: inverse_is_a HGNC:4910 ! HIF1A +relationship: inverse_is_a HGNC:3374 ! EPAS1 +relationship: inverse_is_a HGNC:15825 ! HIF3A [Term] -id: FPLX:HIF_beta +id: FPLX:000232 name: HIF-beta synonym: "HIFbeta" EXACT [] synonym: "Hifbeta" EXACT [] synonym: "HIFβ" EXACT [] synonym: "Hifβ" EXACT [] xref: RE:R-HSA-8936837 -part_of: FPLX:HIF -inverse_is_a: HGNC:ARNT -inverse_is_a: HGNC:ARNT2 -inverse_is_a: HGNC:ARNTL +relationship: part_of FPLX:000229 ! HIF +relationship: inverse_is_a HGNC:700 ! ARNT +relationship: inverse_is_a HGNC:16876 ! ARNT2 +relationship: inverse_is_a HGNC:701 ! ARNTL [Term] -id: FPLX:Histone +id: FPLX:000233 name: Histone synonym: "Histone" EXACT [] synonym: "histone" EXACT [] @@ -3889,34 +3909,34 @@ xref: MEDSCAN:urn:agi-complex:prophash-0f8242e28423189d7ef714808fdcc121 xref: MEDSCAN:urn:agi-protfc:histone xref: MESH:D006657 xref: NCIT:C16687 -is_a: FPLX:root -inverse_is_a: FPLX:Histone_H1 -inverse_is_a: FPLX:Histone_H2A -inverse_is_a: FPLX:Histone_H2B -inverse_is_a: FPLX:Histone_H3 -inverse_is_a: FPLX:Histone_H4 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a FPLX:000234 ! Histone_H1 +relationship: inverse_is_a FPLX:000235 ! Histone_H2A +relationship: inverse_is_a FPLX:000236 ! Histone_H2B +relationship: inverse_is_a FPLX:000237 ! Histone_H3 +relationship: inverse_is_a FPLX:000238 ! Histone_H4 [Term] -id: FPLX:Histone_H1 +id: FPLX:000234 name: Histone-H1 synonym: "histone H1" EXACT [] xref: BEL:"Histone H1 Family" xref: MEDSCAN:urn:agi-protfc:histone%20H1 xref: NCIT:C16683 -is_a: FPLX:Histone -inverse_is_a: HGNC:H1F0 -inverse_is_a: HGNC:H1FOO -inverse_is_a: HGNC:H1FX -inverse_is_a: HGNC:HIST1H1A -inverse_is_a: HGNC:HIST1H1B -inverse_is_a: HGNC:HIST1H1C -inverse_is_a: HGNC:HIST1H1D -inverse_is_a: HGNC:HIST1H1E -inverse_is_a: HGNC:HIST1H1T -inverse_is_a: HGNC:H1FNT - -[Term] -id: FPLX:Histone_H2A +is_a: FPLX:000233 ! Histone +relationship: inverse_is_a HGNC:4714 ! H1F0 +relationship: inverse_is_a HGNC:18463 ! H1FOO +relationship: inverse_is_a HGNC:4722 ! H1FX +relationship: inverse_is_a HGNC:4715 ! HIST1H1A +relationship: inverse_is_a HGNC:4719 ! HIST1H1B +relationship: inverse_is_a HGNC:4716 ! HIST1H1C +relationship: inverse_is_a HGNC:4717 ! HIST1H1D +relationship: inverse_is_a HGNC:4718 ! HIST1H1E +relationship: inverse_is_a HGNC:4720 ! HIST1H1T +relationship: inverse_is_a HGNC:24893 ! H1FNT + +[Term] +id: FPLX:000235 name: Histone-H2A synonym: "Histone 2A" EXACT [] synonym: "Histone H2A" EXACT [] @@ -3925,57 +3945,57 @@ xref: BEL:"Histone H2A Family" xref: MEDSCAN:urn:agi-protfc:histone%20H2A xref: NCIT:C16684 xref: NEXTPROT-FAMILY:01762 -is_a: FPLX:Histone -inverse_is_a: UP:P0C0S8 -inverse_is_a: HGNC:H2AFB1 -inverse_is_a: UP:P0C5Y9 -inverse_is_a: HGNC:H2AFJ -inverse_is_a: HGNC:H2AFV -inverse_is_a: HGNC:H2AFX -inverse_is_a: HGNC:H2AFY -inverse_is_a: HGNC:H2AFY2 -inverse_is_a: HGNC:H2AFZ -inverse_is_a: HGNC:HIST1H2AA -inverse_is_a: HGNC:HIST1H2AC -inverse_is_a: HGNC:HIST1H2AD -inverse_is_a: HGNC:HIST1H2AH -inverse_is_a: HGNC:HIST1H2AJ -inverse_is_a: HGNC:HIST2H2AB -inverse_is_a: HGNC:HIST2H2AC -inverse_is_a: HGNC:HIST3H2A -inverse_is_a: UP:P04908 -inverse_is_a: UP:Q6FI13 - -[Term] -id: FPLX:Histone_H2B +is_a: FPLX:000233 ! Histone +relationship: inverse_is_a UP:H2A1_HUMAN ! P0C0S8 +relationship: inverse_is_a HGNC:22516 ! H2AFB1 +relationship: inverse_is_a UP:H2AB1_HUMAN ! P0C5Y9 +relationship: inverse_is_a HGNC:14456 ! H2AFJ +relationship: inverse_is_a HGNC:20664 ! H2AFV +relationship: inverse_is_a HGNC:4739 ! H2AFX +relationship: inverse_is_a HGNC:4740 ! H2AFY +relationship: inverse_is_a HGNC:14453 ! H2AFY2 +relationship: inverse_is_a HGNC:4741 ! H2AFZ +relationship: inverse_is_a HGNC:18729 ! HIST1H2AA +relationship: inverse_is_a HGNC:4733 ! HIST1H2AC +relationship: inverse_is_a HGNC:4729 ! HIST1H2AD +relationship: inverse_is_a HGNC:13671 ! HIST1H2AH +relationship: inverse_is_a HGNC:4727 ! HIST1H2AJ +relationship: inverse_is_a HGNC:20508 ! HIST2H2AB +relationship: inverse_is_a HGNC:4738 ! HIST2H2AC +relationship: inverse_is_a HGNC:20507 ! HIST3H2A +relationship: inverse_is_a UP:H2A1B_HUMAN ! P04908 +relationship: inverse_is_a UP:H2A2A_HUMAN ! Q6FI13 + +[Term] +id: FPLX:000236 name: Histone-H2B synonym: "H2B" EXACT [] synonym: "histone H2B" EXACT [] xref: BEL:"Histone H2B Family" xref: MEDSCAN:urn:agi-protfc:histone%20H2B -is_a: FPLX:Histone -inverse_is_a: UP:P62807 -inverse_is_a: HGNC:HIST1H2BA -inverse_is_a: HGNC:HIST1H2BB -inverse_is_a: HGNC:HIST1H2BD -inverse_is_a: HGNC:HIST1H2BH -inverse_is_a: HGNC:HIST1H2BJ -inverse_is_a: HGNC:HIST1H2BK -inverse_is_a: HGNC:HIST1H2BL -inverse_is_a: HGNC:HIST1H2BM -inverse_is_a: HGNC:HIST1H2BN -inverse_is_a: HGNC:HIST1H2BO -inverse_is_a: HGNC:HIST2H2BC -inverse_is_a: HGNC:HIST2H2BD -inverse_is_a: HGNC:HIST2H2BE -inverse_is_a: HGNC:HIST2H2BF -inverse_is_a: HGNC:HIST3H2BB -inverse_is_a: HGNC:H2BFS -inverse_is_a: HGNC:H2BFM -inverse_is_a: HGNC:H2BFWT - -[Term] -id: FPLX:Histone_H3 +is_a: FPLX:000233 ! Histone +relationship: inverse_is_a UP:H2B1C_HUMAN ! P62807 +relationship: inverse_is_a HGNC:18730 ! HIST1H2BA +relationship: inverse_is_a HGNC:4751 ! HIST1H2BB +relationship: inverse_is_a HGNC:4747 ! HIST1H2BD +relationship: inverse_is_a HGNC:4755 ! HIST1H2BH +relationship: inverse_is_a HGNC:4761 ! HIST1H2BJ +relationship: inverse_is_a HGNC:13954 ! HIST1H2BK +relationship: inverse_is_a HGNC:4748 ! HIST1H2BL +relationship: inverse_is_a HGNC:4750 ! HIST1H2BM +relationship: inverse_is_a HGNC:4749 ! HIST1H2BN +relationship: inverse_is_a HGNC:4758 ! HIST1H2BO +relationship: inverse_is_a HGNC:20516 ! HIST2H2BC +relationship: inverse_is_a HGNC:20517 ! HIST2H2BD +relationship: inverse_is_a HGNC:4760 ! HIST2H2BE +relationship: inverse_is_a HGNC:24700 ! HIST2H2BF +relationship: inverse_is_a HGNC:20514 ! HIST3H2BB +relationship: inverse_is_a HGNC:4762 ! H2BFS +relationship: inverse_is_a HGNC:27867 ! H2BFM +relationship: inverse_is_a HGNC:27252 ! H2BFWT + +[Term] +id: FPLX:000237 name: Histone-H3 synonym: "H3" EXACT [] synonym: "histone H3" EXACT [] @@ -3985,15 +4005,15 @@ xref: IP:IPR000164 xref: MEDSCAN:urn:agi-protfc:histone%20H3 xref: NCIT:C16685 xref: NEXTPROT-FAMILY:01764 -is_a: FPLX:Histone -inverse_is_a: UP:P68431 -inverse_is_a: UP:Q71DI3 -inverse_is_a: HGNC:HIST3H3 -inverse_is_a: UP:P84243 -inverse_is_a: HGNC:H3F3C +is_a: FPLX:000233 ! Histone +relationship: inverse_is_a UP:H31_HUMAN ! P68431 +relationship: inverse_is_a UP:H32_HUMAN ! Q71DI3 +relationship: inverse_is_a HGNC:4778 ! HIST3H3 +relationship: inverse_is_a UP:H33_HUMAN ! P84243 +relationship: inverse_is_a HGNC:33164 ! H3F3C [Term] -id: FPLX:Histone_H4 +id: FPLX:000238 name: Histone-H4 synonym: "histone H4" EXACT [] xref: BEL:"Histone H4 Family" @@ -4001,25 +4021,25 @@ xref: IP:IPR001951 xref: MEDSCAN:urn:agi-protfc:histone%20H4 xref: NCIT:C16686 xref: NEXTPROT-FAMILY:01765 -is_a: FPLX:Histone -inverse_is_a: UP:P62805 -inverse_is_a: HGNC:HIST1H4G +is_a: FPLX:000233 ! Histone +relationship: inverse_is_a UP:H4_HUMAN ! P62805 +relationship: inverse_is_a HGNC:4792 ! HIST1H4G [Term] -id: FPLX:HLA_DR +id: FPLX:000239 name: HLA-DR synonym: "HLA-DR" EXACT [] xref: BEL:"HLA-DR Family" xref: NCIT:C16692 -is_a: FPLX:root -inverse_is_a: HGNC:HLA-DRA -inverse_is_a: HGNC:HLA-DRB1 -inverse_is_a: HGNC:HLA-DRB3 -inverse_is_a: HGNC:HLA-DRB4 -inverse_is_a: HGNC:HLA-DRB5 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:4947 ! HLA-DRA +relationship: inverse_is_a HGNC:4948 ! HLA-DRB1 +relationship: inverse_is_a HGNC:4951 ! HLA-DRB3 +relationship: inverse_is_a HGNC:4952 ! HLA-DRB4 +relationship: inverse_is_a HGNC:4953 ! HLA-DRB5 [Term] -id: FPLX:HMOX +id: FPLX:000240 name: HMOX synonym: "haem oxygenase" EXACT [] synonym: "heme oxygenase" EXACT [] @@ -4030,86 +4050,86 @@ xref: IP:IPR016053 xref: IP:IPR016084 xref: IP:IPR018207 xref: RE:R-HSA-189382 -is_a: FPLX:root -inverse_is_a: HGNC:HMOX1 -inverse_is_a: HGNC:HMOX2 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:5013 ! HMOX1 +relationship: inverse_is_a HGNC:5014 ! HMOX2 [Term] -id: FPLX:HSP90 +id: FPLX:000241 name: HSP90 synonym: "HSP90" EXACT [] synonym: "Hsp90" EXACT [] xref: BEL:"HSP90 Family" xref: NCIT:C17766 xref: XFAM:PF00183 -is_a: FPLX:root -inverse_is_a: FPLX:HSP90A -inverse_is_a: HGNC:HSP90B1 -inverse_is_a: HGNC:TRAP1 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a FPLX:000242 ! HSP90A +relationship: inverse_is_a HGNC:12028 ! HSP90B1 +relationship: inverse_is_a HGNC:16264 ! TRAP1 [Term] -id: FPLX:HSP90A +id: FPLX:000242 name: HSP90A synonym: "HSP90A" EXACT [] xref: RE:R-HSA-3371429 xref: RE:R-HSA-419619 xref: RE:R-HSA-5082395 xref: RE:R-HSA-5618088 -is_a: FPLX:HSP90 -inverse_is_a: FPLX:HSP90AA -inverse_is_a: HGNC:HSP90AB1 +is_a: FPLX:000241 ! HSP90 +relationship: inverse_is_a FPLX:000243 ! HSP90AA +relationship: inverse_is_a HGNC:5258 ! HSP90AB1 [Term] -id: FPLX:HSP90AA +id: FPLX:000243 name: HSP90AA synonym: "HSP90AA" EXACT [] xref: RE:R-HSA-1218829 xref: RE:R-HSA-1221657 xref: RE:R-HSA-5082406 -is_a: FPLX:HSP90A -inverse_is_a: HGNC:HSP90AA1 +is_a: FPLX:000242 ! HSP90A +relationship: inverse_is_a HGNC:5253 ! HSP90AA1 [Term] -id: FPLX:HSPA +id: FPLX:000244 name: HSPA synonym: "Heat Shock Protein 70" EXACT [] synonym: "HSP70" EXACT [] synonym: "Hsp70" EXACT [] xref: BEL:"HSPA Family" xref: XFAM:PF00012 -is_a: FPLX:root -inverse_is_a: HGNC:HSPA12A -inverse_is_a: HGNC:HSPA12B -inverse_is_a: HGNC:HSPA13 -inverse_is_a: HGNC:HSPA14 -inverse_is_a: HGNC:HSPA1A -inverse_is_a: HGNC:HSPA1B -inverse_is_a: HGNC:HSPA1L -inverse_is_a: HGNC:HSPA2 -inverse_is_a: HGNC:HSPA4 -inverse_is_a: HGNC:HSPA4L -inverse_is_a: HGNC:HSPA5 -inverse_is_a: HGNC:HSPA6 -inverse_is_a: HGNC:HSPA8 -inverse_is_a: HGNC:HSPA9 -inverse_is_a: HGNC:HSPH1 -inverse_is_a: HGNC:HYOU1 - -[Term] -id: FPLX:HSPB +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:19022 ! HSPA12A +relationship: inverse_is_a HGNC:16193 ! HSPA12B +relationship: inverse_is_a HGNC:11375 ! HSPA13 +relationship: inverse_is_a HGNC:29526 ! HSPA14 +relationship: inverse_is_a HGNC:5232 ! HSPA1A +relationship: inverse_is_a HGNC:5233 ! HSPA1B +relationship: inverse_is_a HGNC:5234 ! HSPA1L +relationship: inverse_is_a HGNC:5235 ! HSPA2 +relationship: inverse_is_a HGNC:5237 ! HSPA4 +relationship: inverse_is_a HGNC:17041 ! HSPA4L +relationship: inverse_is_a HGNC:5238 ! HSPA5 +relationship: inverse_is_a HGNC:5239 ! HSPA6 +relationship: inverse_is_a HGNC:5241 ! HSPA8 +relationship: inverse_is_a HGNC:5244 ! HSPA9 +relationship: inverse_is_a HGNC:16969 ! HSPH1 +relationship: inverse_is_a HGNC:16931 ! HYOU1 + +[Term] +id: FPLX:000245 name: HSPB synonym: "heat shock protein family B" EXACT [] synonym: "HSPB proteins" EXACT [] synonym: "HSPB" EXACT [] synonym: "small HSPs" EXACT [] xref: BEL:"HSPB Family" -is_a: FPLX:root -inverse_is_a: HGNC:HSPB1 -inverse_is_a: HGNC:HSPB2 -inverse_is_a: HGNC:HSPB8 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:5246 ! HSPB1 +relationship: inverse_is_a HGNC:5247 ! HSPB2 +relationship: inverse_is_a HGNC:30171 ! HSPB8 [Term] -id: FPLX:IFNA +id: FPLX:000246 name: IFNA synonym: "IFN-a" EXACT [] synonym: "IFN-alpha" EXACT [] @@ -4118,23 +4138,23 @@ synonym: "IFNalpha" EXACT [] synonym: "IFNα" EXACT [] xref: BEL:"IFNA Family" xref: RE:R-HSA-909688 -is_a: FPLX:Interferon -inverse_is_a: HGNC:IFNA1 -inverse_is_a: HGNC:IFNA2 -inverse_is_a: HGNC:IFNA4 -inverse_is_a: HGNC:IFNA5 -inverse_is_a: HGNC:IFNA6 -inverse_is_a: HGNC:IFNA7 -inverse_is_a: HGNC:IFNA8 -inverse_is_a: HGNC:IFNA10 -inverse_is_a: HGNC:IFNA13 -inverse_is_a: HGNC:IFNA14 -inverse_is_a: HGNC:IFNA16 -inverse_is_a: HGNC:IFNA17 -inverse_is_a: HGNC:IFNA21 - -[Term] -id: FPLX:IFNB +is_a: FPLX:000262 ! Interferon +relationship: inverse_is_a HGNC:5417 ! IFNA1 +relationship: inverse_is_a HGNC:5423 ! IFNA2 +relationship: inverse_is_a HGNC:5425 ! IFNA4 +relationship: inverse_is_a HGNC:5426 ! IFNA5 +relationship: inverse_is_a HGNC:5427 ! IFNA6 +relationship: inverse_is_a HGNC:5428 ! IFNA7 +relationship: inverse_is_a HGNC:5429 ! IFNA8 +relationship: inverse_is_a HGNC:5418 ! IFNA10 +relationship: inverse_is_a HGNC:5419 ! IFNA13 +relationship: inverse_is_a HGNC:5420 ! IFNA14 +relationship: inverse_is_a HGNC:5421 ! IFNA16 +relationship: inverse_is_a HGNC:5422 ! IFNA17 +relationship: inverse_is_a HGNC:5424 ! IFNA21 + +[Term] +id: FPLX:000247 name: IFNB synonym: "beta interferons" EXACT [] synonym: "IFN-beta" EXACT [] @@ -4146,11 +4166,11 @@ synonym: "interferon β" EXACT [] synonym: "β interferons" EXACT [] xref: IP:IPR015588 xref: NCIT:C20495 -is_a: FPLX:Interferon -inverse_is_a: HGNC:IFNB1 +is_a: FPLX:000262 ! Interferon +relationship: inverse_is_a HGNC:5434 ! IFNB1 [Term] -id: FPLX:IGFBP +id: FPLX:000248 name: IGFBP synonym: "IGF-BP" EXACT [] synonym: "IGFBP" EXACT [] @@ -4159,25 +4179,25 @@ synonym: "insulin-like growth factor binding proteins" EXACT [] xref: BEL:"IGFBP Family" xref: MEDSCAN:urn:agi-aopfc:0000586 xref: XFAM:PF00219 -is_a: FPLX:root -inverse_is_a: HGNC:IGFBP1 -inverse_is_a: HGNC:IGFBP2 -inverse_is_a: HGNC:IGFBP3 -inverse_is_a: HGNC:IGFBP4 -inverse_is_a: HGNC:IGFBP5 -inverse_is_a: HGNC:IGFBP6 -inverse_is_a: HGNC:IGFBP7 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:5469 ! IGFBP1 +relationship: inverse_is_a HGNC:5471 ! IGFBP2 +relationship: inverse_is_a HGNC:5472 ! IGFBP3 +relationship: inverse_is_a HGNC:5473 ! IGFBP4 +relationship: inverse_is_a HGNC:5474 ! IGFBP5 +relationship: inverse_is_a HGNC:5475 ! IGFBP6 +relationship: inverse_is_a HGNC:5476 ! IGFBP7 [Term] -id: FPLX:IKB +id: FPLX:000249 name: IKB synonym: "IkappaB" EXACT [] synonym: "IκB" EXACT [] xref: NCIT:C17583 -is_a: FPLX:root +is_a: FPLX:000000 ! famplex [Term] -id: FPLX:IKK_complex +id: FPLX:000250 name: IKK-complex synonym: "IKK complex" EXACT [] xref: BEL:"IkappaB Kinase Complex" @@ -4189,13 +4209,13 @@ xref: RE:R-HSA-202513 xref: RE:R-HSA-202562 xref: RE:R-HSA-5262981 xref: RE:R-HSA-727820 -is_a: FPLX:root -has_part: HGNC:CHUK -has_part: HGNC:IKBKB -has_part: HGNC:IKBKG +is_a: FPLX:000000 ! famplex +relationship: has_part HGNC:1974 ! CHUK +relationship: has_part HGNC:5960 ! IKBKB +relationship: has_part HGNC:5961 ! IKBKG [Term] -id: FPLX:IKK_family +id: FPLX:000251 name: IKK-family synonym: "IkappaB kinase" EXACT [] synonym: "IKK" EXACT [] @@ -4203,15 +4223,15 @@ synonym: "IκB kinase" EXACT [] xref: BEL:"IkappaB Kinase Family" xref: NCIT:C104199 xref: NEXTPROT-FAMILY:03104 -is_a: FPLX:root -inverse_is_a: HGNC:CHUK -inverse_is_a: HGNC:IKBKB -inverse_is_a: HGNC:IKBKG -inverse_is_a: HGNC:IKBKE -inverse_is_a: HGNC:TBK1 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:1974 ! CHUK +relationship: inverse_is_a HGNC:5960 ! IKBKB +relationship: inverse_is_a HGNC:5961 ! IKBKG +relationship: inverse_is_a HGNC:14552 ! IKBKE +relationship: inverse_is_a HGNC:11584 ! TBK1 [Term] -id: FPLX:IL1 +id: FPLX:000252 name: IL1 synonym: "IL-1" EXACT [] synonym: "IL1 family" EXACT [] @@ -4222,12 +4242,12 @@ xref: NCIT:C20506 xref: NEXTPROT-FAMILY:01820 xref: XFAM:PF00340 xref: RE:R-HSA-445744 -is_a: FPLX:root -inverse_is_a: HGNC:IL1A -inverse_is_a: HGNC:IL1B +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:5991 ! IL1A +relationship: inverse_is_a HGNC:5992 ! IL1B [Term] -id: FPLX:IL12 +id: FPLX:000253 name: IL12 synonym: "IL-12" EXACT [] synonym: "IL12" EXACT [] @@ -4238,67 +4258,67 @@ xref: RE:R-HSA-447102 xref: RE:R-HSA-8950122 xref: RE:R-HSA-8950228 xref: RE:R-HSA-8950694 -is_a: FPLX:root -inverse_is_a: HGNC:IL12A -inverse_is_a: HGNC:IL12B +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:5969 ! IL12A +relationship: inverse_is_a HGNC:5970 ! IL12B [Term] -id: FPLX:IL15R +id: FPLX:000254 name: IL15R synonym: "IL-15 receptor" EXACT [] synonym: "IL-15R" EXACT [] -is_a: FPLX:root -has_part: HGNC:IL15RA -has_part: HGNC:IL2RB -has_part: HGNC:IL2RG +is_a: FPLX:000000 ! famplex +relationship: has_part HGNC:5978 ! IL15RA +relationship: has_part HGNC:6009 ! IL2RB +relationship: has_part HGNC:6010 ! IL2RG [Term] -id: FPLX:IL2R +id: FPLX:000255 name: IL2R synonym: "IL-2 receptor" EXACT [] synonym: "IL-2R" EXACT [] -is_a: FPLX:root -has_part: HGNC:IL2RA -has_part: HGNC:IL2RB -has_part: HGNC:IL2RG +is_a: FPLX:000000 ! famplex +relationship: has_part HGNC:6008 ! IL2RA +relationship: has_part HGNC:6009 ! IL2RB +relationship: has_part HGNC:6010 ! IL2RG [Term] -id: FPLX:Inhibin +id: FPLX:000256 name: Inhibin synonym: "Inhibin" EXACT [] synonym: "inhibin" EXACT [] xref: GO:0043511 xref: NCIT:C2276 xref: RE:R-HSA-1449688 -is_a: FPLX:root -inverse_is_a: FPLX:Inhibin_A -inverse_is_a: FPLX:Inhibin_B +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a FPLX:000257 ! Inhibin_A +relationship: inverse_is_a FPLX:000258 ! Inhibin_B [Term] -id: FPLX:Inhibin_A +id: FPLX:000257 name: Inhibin-A synonym: "inhibin A" EXACT [] synonym: "inhibin-A" EXACT [] synonym: "inhibin-a" EXACT [] xref: MEDSCAN:urn:agi-complex:inhibin%20A xref: NCIT:C2277 -is_a: FPLX:Inhibin -has_part: HGNC:INHA -has_part: HGNC:INHBA +is_a: FPLX:000256 ! Inhibin +relationship: has_part HGNC:6065 ! INHA +relationship: has_part HGNC:6066 ! INHBA [Term] -id: FPLX:Inhibin_B +id: FPLX:000258 name: Inhibin-B synonym: "inhibin B" EXACT [] synonym: "inhibin-B" EXACT [] synonym: "inhibin-b" EXACT [] xref: NCIT:C2278 -is_a: FPLX:Inhibin -has_part: HGNC:INHA -has_part: HGNC:INHBB +is_a: FPLX:000256 ! Inhibin +relationship: has_part HGNC:6065 ! INHA +relationship: has_part HGNC:6067 ! INHBB [Term] -id: FPLX:INS +id: FPLX:000259 name: INS synonym: "insulin family" EXACT [] xref: BEL:"INS Family" @@ -4310,11 +4330,11 @@ xref: RE:R-HSA-429407 xref: RE:R-HSA-429472 xref: RE:R-HSA-74674 xref: RE:R-HSA-77385 -is_a: FPLX:root -inverse_is_a: HGNC:INS +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:6081 ! INS [Term] -id: FPLX:INSR +id: FPLX:000260 name: INSR synonym: "Insulin receptor family" EXACT [] synonym: "insulin receptor family" EXACT [] @@ -4323,13 +4343,13 @@ xref: BEL:"INSR Family" xref: IP:IPR016246 xref: MEDSCAN:urn:agi-aopfc:0000264 xref: NEXTPROT-FAMILY:03128 -is_a: FPLX:root -inverse_is_a: HGNC:IGF1R -inverse_is_a: HGNC:INSR -inverse_is_a: HGNC:INSRR +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:5465 ! IGF1R +relationship: inverse_is_a HGNC:6091 ! INSR +relationship: inverse_is_a HGNC:6093 ! INSRR [Term] -id: FPLX:Integrins +id: FPLX:000261 name: Integrins synonym: "alpha2beta1 integrin" EXACT [] synonym: "integrin" EXACT [] @@ -4342,24 +4362,24 @@ xref: GO:0034683 xref: GO:0034687 xref: MEDSCAN:urn:agi-complex:MAC-1%20(integrin) xref: NCIT:C16748 -is_a: FPLX:root +is_a: FPLX:000000 ! famplex [Term] -id: FPLX:Interferon +id: FPLX:000262 name: Interferon synonym: "IFN" EXACT [] synonym: "interferon" EXACT [] xref: MEDSCAN:urn:agi-protfc:interferon xref: NCIT:C20493 xref: XFAM:PF00143 -is_a: FPLX:root -inverse_is_a: FPLX:IFNA -inverse_is_a: FPLX:IFNB -inverse_is_a: HGNC:IFNK -inverse_is_a: HGNC:IFNW1 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a FPLX:000246 ! IFNA +relationship: inverse_is_a FPLX:000247 ! IFNB +relationship: inverse_is_a HGNC:21714 ! IFNK +relationship: inverse_is_a HGNC:5448 ! IFNW1 [Term] -id: FPLX:Interferon_gamma_receptor +id: FPLX:000263 name: Interferon-gamma-receptor synonym: "IFNGR" EXACT [] synonym: "interferon gamma receptor" EXACT [] @@ -4368,12 +4388,12 @@ synonym: "interferon-gamma receptor" EXACT [] synonym: "interferon-γ receptor" EXACT [] xref: BEL:"Interferon Gamma Receptor Complex" xref: MEDSCAN:urn:agi-complex:IFNGR -is_a: FPLX:root -has_part: HGNC:IFNGR1 -has_part: HGNC:IFNGR2 +is_a: FPLX:000000 ! famplex +relationship: has_part HGNC:5439 ! IFNGR1 +relationship: has_part HGNC:5440 ! IFNGR2 [Term] -id: FPLX:IRS +id: FPLX:000264 name: IRS synonym: "insulin receptor substrate" EXACT [] synonym: "IRS family" EXACT [] @@ -4383,30 +4403,30 @@ xref: MEDSCAN:urn:agi-aopfc:0000585 xref: XFAM:PF02174 xref: RE:R-HSA-2445131 xref: RE:R-HSA-2445139 -is_a: FPLX:root -inverse_is_a: HGNC:IRS1 -inverse_is_a: HGNC:IRS2 -inverse_is_a: HGNC:IRS4 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:6125 ! IRS1 +relationship: inverse_is_a HGNC:6126 ! IRS2 +relationship: inverse_is_a HGNC:6128 ! IRS4 [Term] -id: FPLX:IRX +id: FPLX:000265 name: IRX synonym: "homeodomain iroquois proteins" EXACT [] synonym: "Iroquois family" EXACT [] synonym: "Iroquois proteins" EXACT [] synonym: "Iroquois-class homeodomain proteins" EXACT [] xref: BEL:"IRX Family" -is_a: FPLX:root -inverse_is_a: HGNC:IRX1 -inverse_is_a: HGNC:IRX2 -inverse_is_a: HGNC:IRX3 -inverse_is_a: HGNC:IRX4 -inverse_is_a: HGNC:IRX5 -inverse_is_a: HGNC:IRX6 -inverse_is_a: HGNC:MKX +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:14358 ! IRX1 +relationship: inverse_is_a HGNC:14359 ! IRX2 +relationship: inverse_is_a HGNC:14360 ! IRX3 +relationship: inverse_is_a HGNC:6129 ! IRX4 +relationship: inverse_is_a HGNC:14361 ! IRX5 +relationship: inverse_is_a HGNC:14675 ! IRX6 +relationship: inverse_is_a HGNC:23729 ! MKX [Term] -id: FPLX:JAK +id: FPLX:000266 name: JAK synonym: "JAK" EXACT [] synonym: "Jak" EXACT [] @@ -4415,14 +4435,14 @@ xref: BEL:"JAK Family" xref: IP:IPR016251 xref: MEDSCAN:urn:agi-aopfc:0000464 xref: NEXTPROT-FAMILY:03129 -is_a: FPLX:root -inverse_is_a: HGNC:JAK1 -inverse_is_a: HGNC:JAK2 -inverse_is_a: HGNC:JAK3 -inverse_is_a: HGNC:TYK2 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:6190 ! JAK1 +relationship: inverse_is_a HGNC:6192 ! JAK2 +relationship: inverse_is_a HGNC:6193 ! JAK3 +relationship: inverse_is_a HGNC:12440 ! TYK2 [Term] -id: FPLX:JNK +id: FPLX:000267 name: JNK synonym: "c-JNK" EXACT [] synonym: "c-Jun N-terminal kinase" EXACT [] @@ -4438,66 +4458,66 @@ xref: RE:R-HSA-450226 xref: RE:R-HSA-450253 xref: RE:R-HSA-450289 xref: SIGNOR:SIGNOR-PF15 -is_a: FPLX:MAPK -inverse_is_a: HGNC:MAPK8 -inverse_is_a: HGNC:MAPK9 -inverse_is_a: HGNC:MAPK10 +is_a: FPLX:000283 ! MAPK +relationship: inverse_is_a HGNC:6881 ! MAPK8 +relationship: inverse_is_a HGNC:6886 ! MAPK9 +relationship: inverse_is_a HGNC:6872 ! MAPK10 [Term] -id: FPLX:JUN_family +id: FPLX:000268 name: JUN-family synonym: "JUN" EXACT [] xref: IP:IPR002112 xref: IP:IPR005643 xref: MEDSCAN:urn:agi-complex:prophash-8d885376e30916afd0b47ccf1b044e75 -part_of: FPLX:AP1 -inverse_is_a: HGNC:JUN -inverse_is_a: HGNC:JUNB -inverse_is_a: HGNC:JUND +relationship: part_of FPLX:000048 ! AP1 +relationship: inverse_is_a HGNC:6204 ! JUN +relationship: inverse_is_a HGNC:6205 ! JUNB +relationship: inverse_is_a HGNC:6206 ! JUND [Term] -id: FPLX:Kainate_family +id: FPLX:000269 name: Kainate-family synonym: "Glutamate receptors, ionotropic, kainate" EXACT [] synonym: "Kainate receptors" EXACT [] synonym: "KARs" EXACT [] xref: GFAM:1199 -is_a: FPLX:root -inverse_is_a: HGNC:GRIK1 -inverse_is_a: HGNC:GRIK2 -inverse_is_a: HGNC:GRIK3 -inverse_is_a: HGNC:GRIK4 -inverse_is_a: HGNC:GRIK5 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:4579 ! GRIK1 +relationship: inverse_is_a HGNC:4580 ! GRIK2 +relationship: inverse_is_a HGNC:4581 ! GRIK3 +relationship: inverse_is_a HGNC:4582 ! GRIK4 +relationship: inverse_is_a HGNC:4583 ! GRIK5 [Term] -id: FPLX:Kinetochore +id: FPLX:000270 name: Kinetochore synonym: "kinetochore complex" EXACT [] synonym: "kinetochore" EXACT [] synonym: "kinetochores" EXACT [] xref: BEL:"Kinetochore Complex" xref: GO:0000776 -is_a: FPLX:root -has_part: HGNC:BUB1 -has_part: HGNC:BUB1B -has_part: HGNC:BUB3 -has_part: HGNC:CENPC -has_part: HGNC:CENPE -has_part: HGNC:CENPF -has_part: HGNC:CENPH -has_part: HGNC:DCTN2 -has_part: HGNC:KIF22 -has_part: HGNC:MAD2L1 -has_part: HGNC:PAFAH1B1 -has_part: HGNC:PSEN1 -has_part: HGNC:PSEN2 -has_part: HGNC:SMC1A -has_part: HGNC:SUGT1 -has_part: HGNC:SUMO3 -has_part: HGNC:ZW10 - -[Term] -id: FPLX:KLK +is_a: FPLX:000000 ! famplex +relationship: has_part HGNC:1148 ! BUB1 +relationship: has_part HGNC:1149 ! BUB1B +relationship: has_part HGNC:1151 ! BUB3 +relationship: has_part HGNC:1854 ! CENPC +relationship: has_part HGNC:1856 ! CENPE +relationship: has_part HGNC:1857 ! CENPF +relationship: has_part HGNC:17268 ! CENPH +relationship: has_part HGNC:2712 ! DCTN2 +relationship: has_part HGNC:6391 ! KIF22 +relationship: has_part HGNC:6763 ! MAD2L1 +relationship: has_part HGNC:8574 ! PAFAH1B1 +relationship: has_part HGNC:9508 ! PSEN1 +relationship: has_part HGNC:9509 ! PSEN2 +relationship: has_part HGNC:11111 ! SMC1A +relationship: has_part HGNC:16987 ! SUGT1 +relationship: has_part HGNC:11124 ! SUMO3 +relationship: has_part HGNC:13194 ! ZW10 + +[Term] +id: FPLX:000271 name: KLK synonym: "kallikrein" EXACT [] synonym: "kallikrein-related peptidases" EXACT [] @@ -4507,47 +4527,47 @@ synonym: "tissue kallikreins" EXACT [] xref: BEL:"KLK Family" xref: ECCODE:3.4.21.35 xref: MEDSCAN:urn:agi-protfc:kallikrein -is_a: FPLX:root -inverse_is_a: HGNC:KLK1 -inverse_is_a: HGNC:KLK10 -inverse_is_a: HGNC:KLK11 -inverse_is_a: HGNC:KLK12 -inverse_is_a: HGNC:KLK13 -inverse_is_a: HGNC:KLK14 -inverse_is_a: HGNC:KLK15 -inverse_is_a: HGNC:KLK2 -inverse_is_a: HGNC:KLK3 -inverse_is_a: HGNC:KLK4 -inverse_is_a: HGNC:KLK5 -inverse_is_a: HGNC:KLK6 -inverse_is_a: HGNC:KLK7 -inverse_is_a: HGNC:KLK8 -inverse_is_a: HGNC:KLK9 -inverse_is_a: HGNC:KLKB1 - -[Term] -id: FPLX:KSR +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:6357 ! KLK1 +relationship: inverse_is_a HGNC:6358 ! KLK10 +relationship: inverse_is_a HGNC:6359 ! KLK11 +relationship: inverse_is_a HGNC:6360 ! KLK12 +relationship: inverse_is_a HGNC:6361 ! KLK13 +relationship: inverse_is_a HGNC:6362 ! KLK14 +relationship: inverse_is_a HGNC:20453 ! KLK15 +relationship: inverse_is_a HGNC:6363 ! KLK2 +relationship: inverse_is_a HGNC:6364 ! KLK3 +relationship: inverse_is_a HGNC:6365 ! KLK4 +relationship: inverse_is_a HGNC:6366 ! KLK5 +relationship: inverse_is_a HGNC:6367 ! KLK6 +relationship: inverse_is_a HGNC:6368 ! KLK7 +relationship: inverse_is_a HGNC:6369 ! KLK8 +relationship: inverse_is_a HGNC:6370 ! KLK9 +relationship: inverse_is_a HGNC:6371 ! KLKB1 + +[Term] +id: FPLX:000272 name: KSR synonym: "KSR" EXACT [] xref: IP:IPR025561 -is_a: FPLX:root -inverse_is_a: HGNC:KSR1 -inverse_is_a: HGNC:KSR2 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:6465 ! KSR1 +relationship: inverse_is_a HGNC:18610 ! KSR2 [Term] -id: FPLX:Laminin_111 +id: FPLX:000273 name: Laminin-111 synonym: "LM-1" EXACT [] xref: BEL:"Laminin 1 Complex" xref: RE:R-HSA-215989 xref: RE:R-HSA-2426371 -is_a: FPLX:root -has_part: HGNC:LAMA1 -has_part: HGNC:LAMB1 -has_part: HGNC:LAMC1 +is_a: FPLX:000000 ! famplex +relationship: has_part HGNC:6481 ! LAMA1 +relationship: has_part HGNC:6486 ! LAMB1 +relationship: has_part HGNC:6492 ! LAMC1 [Term] -id: FPLX:Laminin_332 +id: FPLX:000274 name: Laminin-332 synonym: "laminin 332 chains" EXACT [] synonym: "laminin 332" EXACT [] @@ -4561,25 +4581,25 @@ xref: RE:R-HSA-216001 xref: RE:R-HSA-2220790 xref: RE:R-HSA-2399659 xref: RE:R-HSA-2533911 -is_a: FPLX:root -has_part: HGNC:LAMA3 -has_part: HGNC:LAMB3 -has_part: HGNC:LAMC2 +is_a: FPLX:000000 ! famplex +relationship: has_part HGNC:6483 ! LAMA3 +relationship: has_part HGNC:6490 ! LAMB3 +relationship: has_part HGNC:6493 ! LAMC2 [Term] -id: FPLX:LDH +id: FPLX:000275 name: LDH synonym: "LDH" EXACT [] xref: BEL:"LDH Family" xref: NCIT:C25184 xref: NEXTPROT-FAMILY:02022 -is_a: FPLX:root -inverse_is_a: HGNC:LDHA -inverse_is_a: HGNC:LDHB -inverse_is_a: HGNC:LDHC +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:6535 ! LDHA +relationship: inverse_is_a HGNC:6541 ! LDHB +relationship: inverse_is_a HGNC:6544 ! LDHC [Term] -id: FPLX:LH +id: FPLX:000276 name: LH synonym: "LH" EXACT [] synonym: "Luteinizing hormone" EXACT [] @@ -4590,21 +4610,21 @@ xref: MEDSCAN:urn:agi-complex:Luteinizing%20hormone xref: RE:R-HSA-378969 xref: RE:R-HSA-6793931 xref: RE:R-HSA-6793934 -is_a: FPLX:root -has_part: HGNC:CGA -has_part: HGNC:LHB +is_a: FPLX:000000 ! famplex +relationship: has_part HGNC:1885 ! CGA +relationship: has_part HGNC:6584 ! LHB [Term] -id: FPLX:LPAR +id: FPLX:000277 name: LPAR xref: SIGNOR:SIGNOR-PF2 -is_a: FPLX:root -inverse_is_a: HGNC:LPAR1 -inverse_is_a: HGNC:LPAR2 -inverse_is_a: HGNC:LPAR3 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:3166 ! LPAR1 +relationship: inverse_is_a HGNC:3168 ! LPAR2 +relationship: inverse_is_a HGNC:14298 ! LPAR3 [Term] -id: FPLX:MAC +id: FPLX:000278 name: MAC synonym: "MAC" EXACT [] synonym: "membrane attack complex" EXACT [] @@ -4613,17 +4633,17 @@ xref: BEL:"Membrane Attack Complex" xref: GO:0005579 xref: RE:R-HSA-173728 xref: RE:R-HSA-8852568 -is_a: FPLX:root -has_part: HGNC:C5 -has_part: HGNC:C6 -has_part: HGNC:C7 -has_part: HGNC:C8A -has_part: HGNC:C8B -has_part: HGNC:C8G -has_part: HGNC:C9 +is_a: FPLX:000000 ! famplex +relationship: has_part HGNC:1331 ! C5 +relationship: has_part HGNC:1339 ! C6 +relationship: has_part HGNC:1346 ! C7 +relationship: has_part HGNC:1352 ! C8A +relationship: has_part HGNC:1353 ! C8B +relationship: has_part HGNC:1354 ! C8G +relationship: has_part HGNC:1358 ! C9 [Term] -id: FPLX:MAF +id: FPLX:000279 name: MAF synonym: "Maf subfamily" EXACT [] synonym: "MAF" EXACT [] @@ -4633,71 +4653,71 @@ xref: BEL:"MAF Family" xref: IP:IPR004826 xref: MEDSCAN:urn:agi-aopfc:0000142 xref: XFAM:PF02545 -is_a: FPLX:root -inverse_is_a: HGNC:MAF -inverse_is_a: HGNC:MAFA -inverse_is_a: HGNC:MAFB -inverse_is_a: HGNC:MAFF -inverse_is_a: HGNC:MAFG -inverse_is_a: HGNC:MAFK +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:6776 ! MAF +relationship: inverse_is_a HGNC:23145 ! MAFA +relationship: inverse_is_a HGNC:6408 ! MAFB +relationship: inverse_is_a HGNC:6780 ! MAFF +relationship: inverse_is_a HGNC:6781 ! MAFG +relationship: inverse_is_a HGNC:6782 ! MAFK [Term] -id: FPLX:MAP1LC3 +id: FPLX:000280 name: MAP1LC3 synonym: "LC3" EXACT [] xref: IP:IPR004241 -is_a: FPLX:root -inverse_is_a: HGNC:MAP1LC3A -inverse_is_a: HGNC:MAP1LC3B -inverse_is_a: HGNC:MAP1LC3B2 -inverse_is_a: HGNC:MAP1LC3C +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:6838 ! MAP1LC3A +relationship: inverse_is_a HGNC:13352 ! MAP1LC3B +relationship: inverse_is_a HGNC:34390 ! MAP1LC3B2 +relationship: inverse_is_a HGNC:13353 ! MAP1LC3C [Term] -id: FPLX:MAP2K +id: FPLX:000281 name: MAP2K synonym: "MAPK kinase" EXACT [] synonym: "mitogen-activated protein kinase kinase" EXACT [] xref: NCIT:C105947 -is_a: FPLX:root -inverse_is_a: FPLX:MEK -inverse_is_a: HGNC:MAP2K3 -inverse_is_a: HGNC:MAP2K4 -inverse_is_a: HGNC:MAP2K5 -inverse_is_a: HGNC:MAP2K6 -inverse_is_a: HGNC:MAP2K7 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a FPLX:000286 ! MEK +relationship: inverse_is_a HGNC:6843 ! MAP2K3 +relationship: inverse_is_a HGNC:6844 ! MAP2K4 +relationship: inverse_is_a HGNC:6845 ! MAP2K5 +relationship: inverse_is_a HGNC:6846 ! MAP2K6 +relationship: inverse_is_a HGNC:6847 ! MAP2K7 [Term] -id: FPLX:MAP3K +id: FPLX:000282 name: MAP3K synonym: "MAP3K" EXACT [] synonym: "MAPK kinase kinase" EXACT [] synonym: "MAPKK kinases" EXACT [] synonym: "MAPKKK" EXACT [] xref: ECCODE:2.7.11.25 -is_a: FPLX:root -inverse_is_a: FPLX:RAF -inverse_is_a: HGNC:MAP3K1 -inverse_is_a: HGNC:MAP3K2 -inverse_is_a: HGNC:MAP3K3 -inverse_is_a: HGNC:MAP3K4 -inverse_is_a: HGNC:MAP3K5 -inverse_is_a: HGNC:MAP3K6 -inverse_is_a: HGNC:MAP3K7 -inverse_is_a: HGNC:MAP3K8 -inverse_is_a: HGNC:MAP3K9 -inverse_is_a: HGNC:MAP3K10 -inverse_is_a: HGNC:MAP3K11 -inverse_is_a: HGNC:MAP3K12 -inverse_is_a: HGNC:MAP3K13 -inverse_is_a: HGNC:MAP3K14 -inverse_is_a: HGNC:MAP3K15 -inverse_is_a: FPLX:TAOK -inverse_is_a: HGNC:MAP3K19 -inverse_is_a: HGNC:MAP3K20 -inverse_is_a: HGNC:MAP3K21 - -[Term] -id: FPLX:MAPK +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a FPLX:000399 ! RAF +relationship: inverse_is_a HGNC:6848 ! MAP3K1 +relationship: inverse_is_a HGNC:6854 ! MAP3K2 +relationship: inverse_is_a HGNC:6855 ! MAP3K3 +relationship: inverse_is_a HGNC:6856 ! MAP3K4 +relationship: inverse_is_a HGNC:6857 ! MAP3K5 +relationship: inverse_is_a HGNC:6858 ! MAP3K6 +relationship: inverse_is_a HGNC:6859 ! MAP3K7 +relationship: inverse_is_a HGNC:6860 ! MAP3K8 +relationship: inverse_is_a HGNC:6861 ! MAP3K9 +relationship: inverse_is_a HGNC:6849 ! MAP3K10 +relationship: inverse_is_a HGNC:6850 ! MAP3K11 +relationship: inverse_is_a HGNC:6851 ! MAP3K12 +relationship: inverse_is_a HGNC:6852 ! MAP3K13 +relationship: inverse_is_a HGNC:6853 ! MAP3K14 +relationship: inverse_is_a HGNC:31689 ! MAP3K15 +relationship: inverse_is_a FPLX:000458 ! TAOK +relationship: inverse_is_a HGNC:26249 ! MAP3K19 +relationship: inverse_is_a HGNC:17797 ! MAP3K20 +relationship: inverse_is_a HGNC:29798 ! MAP3K21 + +[Term] +id: FPLX:000283 name: MAPK synonym: "MAP kinase" EXACT [] synonym: "MAP kinases" EXACT [] @@ -4709,13 +4729,13 @@ synonym: "mitogen-activated protein kinases" EXACT [] xref: ECCODE:2.7.11.24 xref: ECCODE:2.7.12.2 xref: NCIT:C16376 -is_a: FPLX:root -inverse_is_a: FPLX:ERK -inverse_is_a: FPLX:p38 -inverse_is_a: FPLX:JNK +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a FPLX:000161 ! ERK +relationship: inverse_is_a FPLX:000326 ! p38 +relationship: inverse_is_a FPLX:000267 ! JNK [Term] -id: FPLX:MCM +id: FPLX:000284 name: MCM synonym: "MCM" EXACT [] synonym: "mini-chromosome maintenance complex" EXACT [] @@ -4727,19 +4747,19 @@ xref: IP:IPR031327 xref: MEDSCAN:urn:agi-complex:prophash-e6be10f6a8e79aed1daa4ec2ac191db1 xref: NEXTPROT-FAMILY:02187 xref: XFAM:PF00493 -is_a: FPLX:root -inverse_is_a: HGNC:MCM2 -inverse_is_a: HGNC:MCM3 -inverse_is_a: HGNC:MCM4 -inverse_is_a: HGNC:MCM5 -inverse_is_a: HGNC:MCM6 -inverse_is_a: HGNC:MCM7 -inverse_is_a: HGNC:MCM8 -inverse_is_a: HGNC:MCM9 -inverse_is_a: HGNC:MCMDC2 - -[Term] -id: FPLX:MEF2 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:6944 ! MCM2 +relationship: inverse_is_a HGNC:6945 ! MCM3 +relationship: inverse_is_a HGNC:6947 ! MCM4 +relationship: inverse_is_a HGNC:6948 ! MCM5 +relationship: inverse_is_a HGNC:6949 ! MCM6 +relationship: inverse_is_a HGNC:6950 ! MCM7 +relationship: inverse_is_a HGNC:16147 ! MCM8 +relationship: inverse_is_a HGNC:21484 ! MCM9 +relationship: inverse_is_a HGNC:26368 ! MCMDC2 + +[Term] +id: FPLX:000285 name: MEF2 synonym: "MEF2 family" EXACT [] synonym: "MEF2" EXACT [] @@ -4748,14 +4768,14 @@ xref: IP:IPR033896 xref: MEDSCAN:urn:agi-aopfc:0000143 xref: RE:R-HSA-448866 xref: RE:R-HSA-448868 -is_a: FPLX:root -inverse_is_a: HGNC:MEF2A -inverse_is_a: HGNC:MEF2C -inverse_is_a: HGNC:MEF2D -inverse_is_a: HGNC:MEF2B +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:6993 ! MEF2A +relationship: inverse_is_a HGNC:6996 ! MEF2C +relationship: inverse_is_a HGNC:6997 ! MEF2D +relationship: inverse_is_a HGNC:6995 ! MEF2B [Term] -id: FPLX:MEK +id: FPLX:000286 name: MEK synonym: "MEK 1/2" EXACT [] synonym: "MEK" EXACT [] @@ -4768,27 +4788,27 @@ xref: RE:R-HSA-5672716 xref: RE:R-HSA-5672721 xref: RE:R-HSA-5674489 xref: SIGNOR:SIGNOR-PF25 -is_a: FPLX:MAP2K -inverse_is_a: HGNC:MAP2K1 -inverse_is_a: HGNC:MAP2K2 +is_a: FPLX:000281 ! MAP2K +relationship: inverse_is_a HGNC:6840 ! MAP2K1 +relationship: inverse_is_a HGNC:6842 ! MAP2K2 [Term] -id: FPLX:MGAT +id: FPLX:000287 name: MGAT synonym: "MGAT" EXACT [] -is_a: FPLX:Glycosyltransferase -inverse_is_a: HGNC:MGAT1 -inverse_is_a: HGNC:MGAT2 -inverse_is_a: HGNC:MGAT3 -inverse_is_a: HGNC:MGAT4A -inverse_is_a: HGNC:MGAT4B -inverse_is_a: HGNC:MGAT4C -inverse_is_a: HGNC:MGAT4D -inverse_is_a: HGNC:MGAT5 -inverse_is_a: HGNC:MGAT5B - -[Term] -id: FPLX:Mitochondrial_Ribosome +is_a: FPLX:000198 ! Glycosyltransferase +relationship: inverse_is_a HGNC:7044 ! MGAT1 +relationship: inverse_is_a HGNC:7045 ! MGAT2 +relationship: inverse_is_a HGNC:7046 ! MGAT3 +relationship: inverse_is_a HGNC:7047 ! MGAT4A +relationship: inverse_is_a HGNC:7048 ! MGAT4B +relationship: inverse_is_a HGNC:30871 ! MGAT4C +relationship: inverse_is_a HGNC:43619 ! MGAT4D +relationship: inverse_is_a HGNC:7049 ! MGAT5 +relationship: inverse_is_a HGNC:24140 ! MGAT5B + +[Term] +id: FPLX:000288 name: Mitochondrial-Ribosome synonym: "mammalian mitochondrial ribosome" EXACT [] synonym: "Mitochondrial ribosome" EXACT [] @@ -4804,195 +4824,195 @@ synonym: "55s mitoribosome" EXACT [] synonym: "55S Mitoribosome" EXACT [] synonym: "55s Mitoribosome" EXACT [] xref: GO:0005761 -is_a: FPLX:root -has_part: FPLX:MRPS -has_part: FPLX:MRPL +is_a: FPLX:000000 ! famplex +relationship: has_part FPLX:000289 ! MRPS +relationship: has_part FPLX:000290 ! MRPL [Term] -id: FPLX:MRPS +id: FPLX:000289 name: MRPS synonym: "small mitoribosomal subunit" EXACT [] synonym: "Small Mitoribosomal Subunit" EXACT [] synonym: "small subunit of the mammalian mitochondrial ribosome" EXACT [] synonym: "mitochondrial ribosomal small subunit" EXACT [] xref: GO:0005763 -part_of: FPLX:Mitochondrial_Ribosome -has_part: HGNC:MRPS2 -has_part: HGNC:MRPS5 -has_part: HGNC:MRPS6 -has_part: HGNC:MRPS7 -has_part: HGNC:MRPS9 -has_part: HGNC:MRPS10 -has_part: HGNC:MRPS11 -has_part: HGNC:MRPS12 -has_part: HGNC:MRPS14 -has_part: HGNC:MRPS15 -has_part: HGNC:MRPS16 -has_part: HGNC:MRPS17 -has_part: HGNC:MRPS18A -has_part: HGNC:MRPS18B -has_part: HGNC:MRPS18C -has_part: HGNC:MRPS21 -has_part: HGNC:MRPS22 -has_part: HGNC:MRPS23 -has_part: HGNC:MRPS24 -has_part: HGNC:MRPS25 -has_part: HGNC:MRPS26 -has_part: HGNC:MRPS27 -has_part: HGNC:MRPS28 -has_part: HGNC:DAP3 -has_part: HGNC:MRPS30 -has_part: HGNC:MRPS31 -has_part: HGNC:MRPS33 -has_part: HGNC:MRPS34 -has_part: HGNC:MRPS35 -has_part: HGNC:MRPS36 - -[Term] -id: FPLX:MRPL +relationship: part_of FPLX:000288 ! Mitochondrial_Ribosome +relationship: has_part HGNC:14495 ! MRPS2 +relationship: has_part HGNC:14498 ! MRPS5 +relationship: has_part HGNC:14051 ! MRPS6 +relationship: has_part HGNC:14499 ! MRPS7 +relationship: has_part HGNC:14501 ! MRPS9 +relationship: has_part HGNC:14502 ! MRPS10 +relationship: has_part HGNC:14050 ! MRPS11 +relationship: has_part HGNC:10380 ! MRPS12 +relationship: has_part HGNC:14049 ! MRPS14 +relationship: has_part HGNC:14504 ! MRPS15 +relationship: has_part HGNC:14048 ! MRPS16 +relationship: has_part HGNC:14047 ! MRPS17 +relationship: has_part HGNC:14515 ! MRPS18A +relationship: has_part HGNC:14516 ! MRPS18B +relationship: has_part HGNC:16633 ! MRPS18C +relationship: has_part HGNC:14046 ! MRPS21 +relationship: has_part HGNC:14508 ! MRPS22 +relationship: has_part HGNC:14509 ! MRPS23 +relationship: has_part HGNC:14510 ! MRPS24 +relationship: has_part HGNC:14511 ! MRPS25 +relationship: has_part HGNC:14045 ! MRPS26 +relationship: has_part HGNC:14512 ! MRPS27 +relationship: has_part HGNC:14513 ! MRPS28 +relationship: has_part HGNC:2673 ! DAP3 +relationship: has_part HGNC:8769 ! MRPS30 +relationship: has_part HGNC:16632 ! MRPS31 +relationship: has_part HGNC:16634 ! MRPS33 +relationship: has_part HGNC:16618 ! MRPS34 +relationship: has_part HGNC:16635 ! MRPS35 +relationship: has_part HGNC:16631 ! MRPS36 + +[Term] +id: FPLX:000290 name: MRPL synonym: "large mitoribosomal subunit" EXACT [] synonym: "Large Mitoribosomal Subunit" EXACT [] synonym: "large subunit of the mammalian mitochondrial ribosome" EXACT [] synonym: "mitochondrial ribosomal large subunit" EXACT [] xref: GO:0005762 -part_of: FPLX:Mitochondrial_Ribosome -has_part: HGNC:MRPL1 -has_part: HGNC:MRPL2 -has_part: HGNC:MRPL3 -has_part: HGNC:MRPL4 -has_part: HGNC:MRPL9 -has_part: HGNC:MRPL10 -has_part: HGNC:MRPL11 -has_part: HGNC:MRPL12 -has_part: HGNC:MRPL13 -has_part: HGNC:MRPL14 -has_part: HGNC:MRPL15 -has_part: HGNC:MRPL16 -has_part: HGNC:MRPL17 -has_part: HGNC:MRPL18 -has_part: HGNC:MRPL19 -has_part: HGNC:MRPL20 -has_part: HGNC:MRPL21 -has_part: HGNC:MRPL22 -has_part: HGNC:MRPL23 -has_part: HGNC:MRPL24 -has_part: HGNC:MRPL27 -has_part: HGNC:MRPL28 -has_part: HGNC:MRPL30 -has_part: HGNC:MRPL32 -has_part: HGNC:MRPL33 -has_part: HGNC:MRPL34 -has_part: HGNC:MRPL35 -has_part: HGNC:MRPL36 -has_part: HGNC:MRPL37 -has_part: HGNC:MRPL38 -has_part: HGNC:MRPL39 -has_part: HGNC:MRPL40 -has_part: HGNC:MRPL41 -has_part: HGNC:MRPL42 -has_part: HGNC:MRPL43 -has_part: HGNC:MRPL44 -has_part: HGNC:MRPL45 -has_part: HGNC:MRPL46 -has_part: HGNC:MRPL47 -has_part: HGNC:MRPL48 -has_part: HGNC:MRPL49 -has_part: HGNC:MRPL50 -has_part: HGNC:MRPL51 -has_part: HGNC:MRPL52 -has_part: HGNC:MRPL53 -has_part: HGNC:MRPL54 -has_part: HGNC:MRPL55 -has_part: HGNC:MRPL57 - -[Term] -id: FPLX:MMP +relationship: part_of FPLX:000288 ! Mitochondrial_Ribosome +relationship: has_part HGNC:14275 ! MRPL1 +relationship: has_part HGNC:14056 ! MRPL2 +relationship: has_part HGNC:10379 ! MRPL3 +relationship: has_part HGNC:14276 ! MRPL4 +relationship: has_part HGNC:14277 ! MRPL9 +relationship: has_part HGNC:14055 ! MRPL10 +relationship: has_part HGNC:14042 ! MRPL11 +relationship: has_part HGNC:10378 ! MRPL12 +relationship: has_part HGNC:14278 ! MRPL13 +relationship: has_part HGNC:14279 ! MRPL14 +relationship: has_part HGNC:14054 ! MRPL15 +relationship: has_part HGNC:14476 ! MRPL16 +relationship: has_part HGNC:14053 ! MRPL17 +relationship: has_part HGNC:14477 ! MRPL18 +relationship: has_part HGNC:14052 ! MRPL19 +relationship: has_part HGNC:14478 ! MRPL20 +relationship: has_part HGNC:14479 ! MRPL21 +relationship: has_part HGNC:14480 ! MRPL22 +relationship: has_part HGNC:10322 ! MRPL23 +relationship: has_part HGNC:14037 ! MRPL24 +relationship: has_part HGNC:14483 ! MRPL27 +relationship: has_part HGNC:14484 ! MRPL28 +relationship: has_part HGNC:14036 ! MRPL30 +relationship: has_part HGNC:14035 ! MRPL32 +relationship: has_part HGNC:14487 ! MRPL33 +relationship: has_part HGNC:14488 ! MRPL34 +relationship: has_part HGNC:14489 ! MRPL35 +relationship: has_part HGNC:14490 ! MRPL36 +relationship: has_part HGNC:14034 ! MRPL37 +relationship: has_part HGNC:14033 ! MRPL38 +relationship: has_part HGNC:14027 ! MRPL39 +relationship: has_part HGNC:14491 ! MRPL40 +relationship: has_part HGNC:14492 ! MRPL41 +relationship: has_part HGNC:14493 ! MRPL42 +relationship: has_part HGNC:14517 ! MRPL43 +relationship: has_part HGNC:16650 ! MRPL44 +relationship: has_part HGNC:16651 ! MRPL45 +relationship: has_part HGNC:1192 ! MRPL46 +relationship: has_part HGNC:16652 ! MRPL47 +relationship: has_part HGNC:16653 ! MRPL48 +relationship: has_part HGNC:1176 ! MRPL49 +relationship: has_part HGNC:16654 ! MRPL50 +relationship: has_part HGNC:14044 ! MRPL51 +relationship: has_part HGNC:16655 ! MRPL52 +relationship: has_part HGNC:16684 ! MRPL53 +relationship: has_part HGNC:16685 ! MRPL54 +relationship: has_part HGNC:16686 ! MRPL55 +relationship: has_part HGNC:14514 ! MRPL57 + +[Term] +id: FPLX:000291 name: MMP synonym: "MMP" EXACT [] synonym: "MMPs" EXACT [] xref: BEL:"MMP Family" xref: NCIT:C18164 -is_a: FPLX:root -inverse_is_a: HGNC:MMP1 -inverse_is_a: HGNC:MMP2 -inverse_is_a: HGNC:MMP3 -inverse_is_a: HGNC:MMP7 -inverse_is_a: HGNC:MMP8 -inverse_is_a: HGNC:MMP9 -inverse_is_a: HGNC:MMP10 -inverse_is_a: HGNC:MMP11 -inverse_is_a: HGNC:MMP12 -inverse_is_a: HGNC:MMP13 -inverse_is_a: HGNC:MMP14 -inverse_is_a: HGNC:MMP15 -inverse_is_a: HGNC:MMP16 -inverse_is_a: HGNC:MMP17 -inverse_is_a: HGNC:MMP19 -inverse_is_a: HGNC:MMP20 -inverse_is_a: HGNC:MMP21 -inverse_is_a: HGNC:MMP23B -inverse_is_a: HGNC:MMP24 -inverse_is_a: HGNC:MMP25 -inverse_is_a: HGNC:MMP26 -inverse_is_a: HGNC:MMP27 -inverse_is_a: HGNC:MMP28 - -[Term] -id: FPLX:Metallothionein +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:7155 ! MMP1 +relationship: inverse_is_a HGNC:7166 ! MMP2 +relationship: inverse_is_a HGNC:7173 ! MMP3 +relationship: inverse_is_a HGNC:7174 ! MMP7 +relationship: inverse_is_a HGNC:7175 ! MMP8 +relationship: inverse_is_a HGNC:7176 ! MMP9 +relationship: inverse_is_a HGNC:7156 ! MMP10 +relationship: inverse_is_a HGNC:7157 ! MMP11 +relationship: inverse_is_a HGNC:7158 ! MMP12 +relationship: inverse_is_a HGNC:7159 ! MMP13 +relationship: inverse_is_a HGNC:7160 ! MMP14 +relationship: inverse_is_a HGNC:7161 ! MMP15 +relationship: inverse_is_a HGNC:7162 ! MMP16 +relationship: inverse_is_a HGNC:7163 ! MMP17 +relationship: inverse_is_a HGNC:7165 ! MMP19 +relationship: inverse_is_a HGNC:7167 ! MMP20 +relationship: inverse_is_a HGNC:14357 ! MMP21 +relationship: inverse_is_a HGNC:7171 ! MMP23B +relationship: inverse_is_a HGNC:7172 ! MMP24 +relationship: inverse_is_a HGNC:14246 ! MMP25 +relationship: inverse_is_a HGNC:14249 ! MMP26 +relationship: inverse_is_a HGNC:14250 ! MMP27 +relationship: inverse_is_a HGNC:14366 ! MMP28 + +[Term] +id: FPLX:000292 name: Metallothionein synonym: "Metallothionein" EXACT [] synonym: "metallothionein" EXACT [] synonym: "MT" EXACT [] -is_a: FPLX:root -inverse_is_a: HGNC:MT1A -inverse_is_a: HGNC:MT1B -inverse_is_a: HGNC:MT1CP -inverse_is_a: HGNC:MT1DP -inverse_is_a: HGNC:MT1E -inverse_is_a: HGNC:MT1F -inverse_is_a: HGNC:MT1G -inverse_is_a: HGNC:MT1H -inverse_is_a: HGNC:MT1HL1 -inverse_is_a: HGNC:MT1IP -inverse_is_a: HGNC:MT1JP -inverse_is_a: HGNC:MT1L -inverse_is_a: HGNC:MT1M -inverse_is_a: HGNC:MT1P1 -inverse_is_a: HGNC:MT1P3 -inverse_is_a: HGNC:MT1X -inverse_is_a: HGNC:MT2A -inverse_is_a: HGNC:MT3 -inverse_is_a: HGNC:MT4 - -[Term] -id: FPLX:mTORC1 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:7393 ! MT1A +relationship: inverse_is_a HGNC:7394 ! MT1B +relationship: inverse_is_a HGNC:7395 ! MT1CP +relationship: inverse_is_a HGNC:7396 ! MT1DP +relationship: inverse_is_a HGNC:7397 ! MT1E +relationship: inverse_is_a HGNC:7398 ! MT1F +relationship: inverse_is_a HGNC:7399 ! MT1G +relationship: inverse_is_a HGNC:7400 ! MT1H +relationship: inverse_is_a HGNC:31864 ! MT1HL1 +relationship: inverse_is_a HGNC:7401 ! MT1IP +relationship: inverse_is_a HGNC:7402 ! MT1JP +relationship: inverse_is_a HGNC:7404 ! MT1L +relationship: inverse_is_a HGNC:14296 ! MT1M +relationship: inverse_is_a HGNC:23681 ! MT1P1 +relationship: inverse_is_a HGNC:16120 ! MT1P3 +relationship: inverse_is_a HGNC:7405 ! MT1X +relationship: inverse_is_a HGNC:7406 ! MT2A +relationship: inverse_is_a HGNC:7408 ! MT3 +relationship: inverse_is_a HGNC:18705 ! MT4 + +[Term] +id: FPLX:000293 name: mTORC1 synonym: "mTORC1" EXACT [] synonym: "TORC1" EXACT [] xref: GO:0031931 xref: MEDSCAN:urn:agi-complex:prophash-f472fef3f59301aee0b776702a30f03e xref: NCIT:C96314 -is_a: FPLX:root -has_part: HGNC:MTOR -has_part: HGNC:RPTOR +is_a: FPLX:000000 ! famplex +relationship: has_part HGNC:3942 ! MTOR +relationship: has_part HGNC:30287 ! RPTOR [Term] -id: FPLX:mTORC2 +id: FPLX:000294 name: mTORC2 synonym: "mTORC2" EXACT [] synonym: "TORC2" EXACT [] xref: BEL:"TORC2 Complex" xref: MEDSCAN:urn:agi-complex:prophash-0d528c29d63997f87f62e4fbd9f0b168 xref: NCIT:C96315 -is_a: FPLX:root -has_part: HGNC:MAPKAP1 -has_part: HGNC:MTOR -has_part: HGNC:RICTOR -has_part: HGNC:MLST8 +is_a: FPLX:000000 ! famplex +relationship: has_part HGNC:18752 ! MAPKAP1 +relationship: has_part HGNC:3942 ! MTOR +relationship: has_part HGNC:28611 ! RICTOR +relationship: has_part HGNC:24825 ! MLST8 [Term] -id: FPLX:MYH +id: FPLX:000295 name: MYH synonym: "myosin heavy chain genes" EXACT [] synonym: "myosin heavy chain isoforms" EXACT [] @@ -5003,25 +5023,25 @@ synonym: "Myosin heavy chains" EXACT [] synonym: "myosin heavy chains" EXACT [] xref: BEL:"MYH Family" xref: MEDSCAN:urn:agi-protfc:myosin%20heavy%20chain -is_a: FPLX:root -inverse_is_a: HGNC:MYH1 -inverse_is_a: HGNC:MYH10 -inverse_is_a: HGNC:MYH11 -inverse_is_a: HGNC:MYH13 -inverse_is_a: HGNC:MYH14 -inverse_is_a: HGNC:MYH15 -inverse_is_a: HGNC:MYH2 -inverse_is_a: HGNC:MYH3 -inverse_is_a: HGNC:MYH4 -inverse_is_a: HGNC:MYH6 -inverse_is_a: HGNC:MYH7 -inverse_is_a: HGNC:MYH7B -inverse_is_a: HGNC:MYH8 -inverse_is_a: HGNC:MYH9 -inverse_is_a: HGNC:MYO5A - -[Term] -id: FPLX:MYL +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:7567 ! MYH1 +relationship: inverse_is_a HGNC:7568 ! MYH10 +relationship: inverse_is_a HGNC:7569 ! MYH11 +relationship: inverse_is_a HGNC:7571 ! MYH13 +relationship: inverse_is_a HGNC:23212 ! MYH14 +relationship: inverse_is_a HGNC:31073 ! MYH15 +relationship: inverse_is_a HGNC:7572 ! MYH2 +relationship: inverse_is_a HGNC:7573 ! MYH3 +relationship: inverse_is_a HGNC:7574 ! MYH4 +relationship: inverse_is_a HGNC:7576 ! MYH6 +relationship: inverse_is_a HGNC:7577 ! MYH7 +relationship: inverse_is_a HGNC:15906 ! MYH7B +relationship: inverse_is_a HGNC:7578 ! MYH8 +relationship: inverse_is_a HGNC:7579 ! MYH9 +relationship: inverse_is_a HGNC:7602 ! MYO5A + +[Term] +id: FPLX:000296 name: MYL synonym: "MLC" EXACT [] synonym: "myosin light chain protein" EXACT [] @@ -5029,107 +5049,107 @@ synonym: "myosin light chain" EXACT [] synonym: "myosin light chains" EXACT [] xref: BEL:"MYL Family" xref: MEDSCAN:urn:agi-protfc:myosin%20light%20chain -is_a: FPLX:root -inverse_is_a: FPLX:MYL_alkali -inverse_is_a: FPLX:MYL_regulatory -inverse_is_a: FPLX:MYL_slow +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a FPLX:000297 ! MYL_alkali +relationship: inverse_is_a FPLX:000298 ! MYL_regulatory +relationship: inverse_is_a FPLX:000299 ! MYL_slow [Term] -id: FPLX:MYL_alkali +id: FPLX:000297 name: MYL-alkali synonym: "alkali myosin light chains" EXACT [] synonym: "AMLC" EXACT [] synonym: "myosin alkali light chain proteins" EXACT [] synonym: "myosin alkali light chain" EXACT [] xref: BEL:"MYL Alkali Family" -is_a: FPLX:MYL -inverse_is_a: HGNC:MYL1 -inverse_is_a: HGNC:MYL3 -inverse_is_a: HGNC:MYL4 -inverse_is_a: HGNC:MYL6 -inverse_is_a: HGNC:MYL6B +is_a: FPLX:000296 ! MYL +relationship: inverse_is_a HGNC:7582 ! MYL1 +relationship: inverse_is_a HGNC:7584 ! MYL3 +relationship: inverse_is_a HGNC:7585 ! MYL4 +relationship: inverse_is_a HGNC:7587 ! MYL6 +relationship: inverse_is_a HGNC:29823 ! MYL6B [Term] -id: FPLX:MYL_regulatory +id: FPLX:000298 name: MYL-regulatory synonym: "regulatory myosin light chain" EXACT [] xref: BEL:"MYL Regulatory Family" -is_a: FPLX:MYL -inverse_is_a: HGNC:MYL10 -inverse_is_a: HGNC:MYL12A -inverse_is_a: HGNC:MYL12B -inverse_is_a: HGNC:MYL2 -inverse_is_a: HGNC:MYL5 -inverse_is_a: HGNC:MYL7 -inverse_is_a: HGNC:MYL9 -inverse_is_a: HGNC:MYLPF - -[Term] -id: FPLX:MYL_slow +is_a: FPLX:000296 ! MYL +relationship: inverse_is_a HGNC:29825 ! MYL10 +relationship: inverse_is_a HGNC:16701 ! MYL12A +relationship: inverse_is_a HGNC:29827 ! MYL12B +relationship: inverse_is_a HGNC:7583 ! MYL2 +relationship: inverse_is_a HGNC:7586 ! MYL5 +relationship: inverse_is_a HGNC:21719 ! MYL7 +relationship: inverse_is_a HGNC:15754 ! MYL9 +relationship: inverse_is_a HGNC:29824 ! MYLPF + +[Term] +id: FPLX:000299 name: MYL-slow synonym: "slow myosin" EXACT [] xref: BEL:"MYL Slow Family" -is_a: FPLX:MYL -inverse_is_a: HGNC:MYL2 -inverse_is_a: HGNC:MYL3 -inverse_is_a: HGNC:MYL6B +is_a: FPLX:000296 ! MYL +relationship: inverse_is_a HGNC:7583 ! MYL2 +relationship: inverse_is_a HGNC:7584 ! MYL3 +relationship: inverse_is_a HGNC:29823 ! MYL6B [Term] -id: FPLX:MYST +id: FPLX:000300 name: MYST synonym: "MYST family" EXACT [] synonym: "MYST histone acetylase" EXACT [] synonym: "MYST proteins" EXACT [] xref: BEL:"MYST Family" xref: IP:IPR002717 -is_a: FPLX:root -inverse_is_a: HGNC:KAT8 -inverse_is_a: HGNC:KAT7 -inverse_is_a: HGNC:KAT6A -inverse_is_a: HGNC:KAT6B -inverse_is_a: HGNC:KAT5 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:17933 ! KAT8 +relationship: inverse_is_a HGNC:17016 ! KAT7 +relationship: inverse_is_a HGNC:13013 ! KAT6A +relationship: inverse_is_a HGNC:17582 ! KAT6B +relationship: inverse_is_a HGNC:5275 ! KAT5 [Term] -id: FPLX:NADH_dehydrogenase +id: FPLX:000301 name: NADH-dehydrogenase synonym: "NADH dehydrogenase (ubiquinone)" EXACT [] synonym: "NADH dehydrogenase" EXACT [] xref: BEL:"NADH Dehydrogenase Complex" xref: ECCODE:1.6.5.3 xref: XFAM:PF00146 -is_a: FPLX:root -has_part: HGNC:MT-ND1 -has_part: HGNC:MT-ND2 -has_part: HGNC:MT-ND3 -has_part: HGNC:MT-ND4 -has_part: HGNC:MT-ND4L -has_part: HGNC:MT-ND5 -has_part: HGNC:MT-ND6 +is_a: FPLX:000000 ! famplex +relationship: has_part HGNC:7455 ! MT-ND1 +relationship: has_part HGNC:7456 ! MT-ND2 +relationship: has_part HGNC:7458 ! MT-ND3 +relationship: has_part HGNC:7459 ! MT-ND4 +relationship: has_part HGNC:7460 ! MT-ND4L +relationship: has_part HGNC:7461 ! MT-ND5 +relationship: has_part HGNC:7462 ! MT-ND6 [Term] -id: FPLX:NADPH_oxidase +id: FPLX:000302 name: NADPH-oxidase synonym: "NAD(P)H oxidase" EXACT [] synonym: "NAD(P)H-oxidase" EXACT [] synonym: "NADPH oxidase" EXACT [] xref: BEL:"NADPH Oxidase Complex" xref: MEDSCAN:urn:agi-aopfc:0000479 -is_a: FPLX:root -has_part: HGNC:CYBA -has_part: HGNC:CYBB -has_part: HGNC:DUOX1 -has_part: HGNC:DUOX2 -has_part: HGNC:NCF1 -has_part: HGNC:NCF2 -has_part: HGNC:NCF4 -has_part: HGNC:NOX1 -has_part: HGNC:NOX3 -has_part: HGNC:NOX4 -has_part: HGNC:NOX5 -has_part: HGNC:RAC1 - -[Term] -id: FPLX:Na_K_ATPase +is_a: FPLX:000000 ! famplex +relationship: has_part HGNC:2577 ! CYBA +relationship: has_part HGNC:2578 ! CYBB +relationship: has_part HGNC:3062 ! DUOX1 +relationship: has_part HGNC:13273 ! DUOX2 +relationship: has_part HGNC:7660 ! NCF1 +relationship: has_part HGNC:7661 ! NCF2 +relationship: has_part HGNC:7662 ! NCF4 +relationship: has_part HGNC:7889 ! NOX1 +relationship: has_part HGNC:7890 ! NOX3 +relationship: has_part HGNC:7891 ! NOX4 +relationship: has_part HGNC:14874 ! NOX5 +relationship: has_part HGNC:9801 ! RAC1 + +[Term] +id: FPLX:000303 name: Na-K-ATPase synonym: "Na(+),K(+)-ATPase" EXACT [] synonym: "Na,K-ATPase" EXACT [] @@ -5138,12 +5158,12 @@ synonym: "Na+/K+ATPase" EXACT [] synonym: "Na/K-ATPase" EXACT [] xref: BEL:"Na/K Exchanging ATPase Complex" xref: ECCODE:3.6.3.9 -is_a: FPLX:root -has_part: FPLX:ATP1A -has_part: FPLX:ATP1B +is_a: FPLX:000000 ! famplex +relationship: has_part FPLX:000057 ! ATP1A +relationship: has_part FPLX:000058 ! ATP1B [Term] -id: FPLX:Natriuretic_peptide +id: FPLX:000304 name: Natriuretic-peptide synonym: "Natriuretic Peptide" EXACT [] synonym: "Natriuretic peptide" EXACT [] @@ -5151,13 +5171,13 @@ synonym: "natriuretic peptide" EXACT [] synonym: "Natriuretic Peptides" EXACT [] synonym: "Natriuretic peptides" EXACT [] synonym: "natriuretic peptides" EXACT [] -is_a: FPLX:root -inverse_is_a: HGNC:NPPA -inverse_is_a: HGNC:NPPB -inverse_is_a: HGNC:NPPC +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:7939 ! NPPA +relationship: inverse_is_a HGNC:7940 ! NPPB +relationship: inverse_is_a HGNC:7941 ! NPPC [Term] -id: FPLX:NCOA +id: FPLX:000305 name: NCOA synonym: "p160/SRC" EXACT [] xref: BEL:"p160/SRC Family" @@ -5165,13 +5185,13 @@ xref: IP:IPR010011 xref: IP:IPR014920 xref: IP:IPR014935 xref: IP:IPR017426 -is_a: FPLX:root -inverse_is_a: HGNC:NCOA1 -inverse_is_a: HGNC:NCOA2 -inverse_is_a: HGNC:NCOA3 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:7668 ! NCOA1 +relationship: inverse_is_a HGNC:7669 ! NCOA2 +relationship: inverse_is_a HGNC:7670 ! NCOA3 [Term] -id: FPLX:NCOR +id: FPLX:000306 name: NCOR synonym: "Nuclear Receptor Co-Repressor" EXACT [] synonym: "nuclear receptor co-repressor" EXACT [] @@ -5179,12 +5199,12 @@ synonym: "Nuclear receptor corepressor" EXACT [] synonym: "nuclear receptor corepressor" EXACT [] xref: BEL:"NCOR Family" xref: RE:R-HSA-349716 -is_a: FPLX:root -inverse_is_a: HGNC:NCOR1 -inverse_is_a: HGNC:NCOR2 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:7672 ! NCOR1 +relationship: inverse_is_a HGNC:7673 ! NCOR2 [Term] -id: FPLX:NDRG +id: FPLX:000307 name: NDRG synonym: "N-myc downstream regulated gene family" EXACT [] synonym: "NDR family" EXACT [] @@ -5192,52 +5212,52 @@ synonym: "NDR-family" EXACT [] xref: BEL:"NDRG Family" xref: IP:IPR004142 xref: XFAM:PF03096 -is_a: FPLX:root -inverse_is_a: HGNC:NDRG1 -inverse_is_a: HGNC:NDRG2 -inverse_is_a: HGNC:NDRG3 -inverse_is_a: HGNC:NDRG4 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:7679 ! NDRG1 +relationship: inverse_is_a HGNC:14460 ! NDRG2 +relationship: inverse_is_a HGNC:14462 ! NDRG3 +relationship: inverse_is_a HGNC:14466 ! NDRG4 [Term] -id: FPLX:Neurexins +id: FPLX:000308 name: Neurexins synonym: "Neurexins" EXACT [] synonym: "NRXN" EXACT [] xref: GFAM:1582 -is_a: FPLX:root -inverse_is_a: HGNC:NRXN1 -inverse_is_a: HGNC:NRXN2 -inverse_is_a: HGNC:NRXN3 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:8008 ! NRXN1 +relationship: inverse_is_a HGNC:8009 ! NRXN2 +relationship: inverse_is_a HGNC:8010 ! NRXN3 [Term] -id: FPLX:NFAT +id: FPLX:000309 name: NFAT synonym: "NFAT" EXACT [] xref: BEL:"NFAT Family" xref: IP:IPR008366 xref: NCIT:C17903 -is_a: FPLX:root -inverse_is_a: HGNC:NFATC1 -inverse_is_a: HGNC:NFATC2 -inverse_is_a: HGNC:NFATC3 -inverse_is_a: HGNC:NFATC4 -inverse_is_a: HGNC:NFAT5 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:7775 ! NFATC1 +relationship: inverse_is_a HGNC:7776 ! NFATC2 +relationship: inverse_is_a HGNC:7777 ! NFATC3 +relationship: inverse_is_a HGNC:7778 ! NFATC4 +relationship: inverse_is_a HGNC:7774 ! NFAT5 [Term] -id: FPLX:NFE +id: FPLX:000310 name: NFE synonym: "NF-E2" EXACT [] synonym: "NF-E2-related factor" EXACT [] synonym: "Nuclear factor erythroid 2-related factor" EXACT [] xref: MEDSCAN:urn:agi-aopfc:0000150 xref: MEDSCAN:urn:agi-complex:NF-E2 -is_a: FPLX:root -inverse_is_a: HGNC:NFE2L1 -inverse_is_a: HGNC:NFE2L2 -inverse_is_a: HGNC:NFE2L3 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:7781 ! NFE2L1 +relationship: inverse_is_a HGNC:7782 ! NFE2L2 +relationship: inverse_is_a HGNC:7783 ! NFE2L3 [Term] -id: FPLX:NFkappaB +id: FPLX:000311 name: NFkappaB synonym: "NF-kappaB complexes" EXACT [] synonym: "NF-kappaB dimers" EXACT [] @@ -5272,12 +5292,12 @@ xref: MEDSCAN:urn:agi-aopfc:0000156 xref: MEDSCAN:urn:agi-complex:prophash-8cfce9bfac3857e6f068d517deadfeaa xref: NCIT:C17380 xref: SIGNOR:SIGNOR-PF12 -is_a: FPLX:root -has_part: FPLX:NFkappaB_1 -has_part: FPLX:NFkappaB_2 +is_a: FPLX:000000 ! famplex +relationship: has_part FPLX:000312 ! NFkappaB_1 +relationship: has_part FPLX:000313 ! NFkappaB_2 [Term] -id: FPLX:NFkappaB_1 +id: FPLX:000312 name: NFkappaB-1 synonym: "Class 1 NF-kappaBs" EXACT [] synonym: "class 1 NF-kappaBs" EXACT [] @@ -5297,12 +5317,12 @@ synonym: "NF-κB Class I" EXACT [] synonym: "NF-κB class I" EXACT [] xref: RE:R-HSA-177656 xref: RE:R-HSA-177662 -part_of: FPLX:NFkappaB -inverse_is_a: HGNC:NFKB1 -inverse_is_a: HGNC:NFKB2 +relationship: part_of FPLX:000311 ! NFkappaB +relationship: inverse_is_a HGNC:7794 ! NFKB1 +relationship: inverse_is_a HGNC:7795 ! NFKB2 [Term] -id: FPLX:NFkappaB_2 +id: FPLX:000313 name: NFkappaB-2 synonym: "Class 2 NF-kappaBs" EXACT [] synonym: "class 2 NF-kappaBs" EXACT [] @@ -5320,13 +5340,13 @@ synonym: "NF-κB Class 2" EXACT [] synonym: "NF-κB class 2" EXACT [] synonym: "NF-κB Class II" EXACT [] synonym: "NF-κB class II" EXACT [] -part_of: FPLX:NFkappaB -inverse_is_a: HGNC:RELA -inverse_is_a: HGNC:RELB -inverse_is_a: HGNC:REL +relationship: part_of FPLX:000311 ! NFkappaB +relationship: inverse_is_a HGNC:9955 ! RELA +relationship: inverse_is_a HGNC:9956 ! RELB +relationship: inverse_is_a HGNC:9954 ! REL [Term] -id: FPLX:NFY +id: FPLX:000314 name: NFY synonym: "NF-Y" EXACT [] synonym: "NFY" EXACT [] @@ -5335,22 +5355,22 @@ synonym: "nuclear factor-Y" EXACT [] xref: BEL:"Nfy Complex" xref: RE:R-HSA-2426131 xref: RE:R-HSA-381204 -is_a: FPLX:root -has_part: HGNC:NFYA -has_part: HGNC:NFYB -has_part: HGNC:NFYC +is_a: FPLX:000000 ! famplex +relationship: has_part HGNC:7804 ! NFYA +relationship: has_part HGNC:7805 ! NFYB +relationship: has_part HGNC:7806 ! NFYC [Term] -id: FPLX:NKD +id: FPLX:000315 name: NKD synonym: "naked cuticle" EXACT [] xref: BEL:"NKD Family" -is_a: FPLX:root -inverse_is_a: HGNC:NKD1 -inverse_is_a: HGNC:NKD2 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:17045 ! NKD1 +relationship: inverse_is_a HGNC:17046 ! NKD2 [Term] -id: FPLX:NOS +id: FPLX:000316 name: NOS synonym: "NOS" EXACT [] xref: BEL:"NOS Family" @@ -5359,13 +5379,13 @@ xref: IP:IPR012144 xref: MEDSCAN:urn:agi-aopfc:0000494 xref: NEXTPROT-FAMILY:02504 xref: RE:R-HSA-419294 -is_a: FPLX:root -inverse_is_a: HGNC:NOS1 -inverse_is_a: HGNC:NOS2 -inverse_is_a: HGNC:NOS3 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:7872 ! NOS1 +relationship: inverse_is_a HGNC:7873 ! NOS2 +relationship: inverse_is_a HGNC:7876 ! NOS3 [Term] -id: FPLX:Notch +id: FPLX:000317 name: Notch synonym: "Notch" EXACT [] xref: BEL:"NOTCH Family" @@ -5382,14 +5402,14 @@ xref: RE:R-HSA-1911547 xref: RE:R-HSA-1911550 xref: RE:R-HSA-212420 xref: SIGNOR:SIGNOR-PF30 -is_a: FPLX:root -inverse_is_a: HGNC:NOTCH1 -inverse_is_a: HGNC:NOTCH2 -inverse_is_a: HGNC:NOTCH3 -inverse_is_a: HGNC:NOTCH4 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:7881 ! NOTCH1 +relationship: inverse_is_a HGNC:7882 ! NOTCH2 +relationship: inverse_is_a HGNC:7883 ! NOTCH3 +relationship: inverse_is_a HGNC:7884 ! NOTCH4 [Term] -id: FPLX:NRG +id: FPLX:000318 name: NRG synonym: "neuregulin family" EXACT [] synonym: "Neuregulin" EXACT [] @@ -5400,12 +5420,12 @@ synonym: "NRGs" EXACT [] xref: MEDSCAN:urn:agi-protfc:neuregulin%20family xref: XFAM:PF02158 xref: RE:R-HSA-1227957 -is_a: FPLX:root -inverse_is_a: FPLX:NRG_1_2 -inverse_is_a: FPLX:NRG_3_4 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a FPLX:000319 ! NRG_1_2 +relationship: inverse_is_a FPLX:000320 ! NRG_3_4 [Term] -id: FPLX:NRG_1_2 +id: FPLX:000319 name: NRG-1-2 synonym: "NRG1-NRG2" EXACT [] synonym: "NRG1/2" EXACT [] @@ -5413,22 +5433,22 @@ xref: BEL:"NRG1/2 Family" xref: RE:R-HSA-1227956 xref: RE:R-HSA-1247495 xref: RE:R-HSA-1248743 -is_a: FPLX:NRG -inverse_is_a: HGNC:NRG1 -inverse_is_a: HGNC:NRG2 +is_a: FPLX:000318 ! NRG +relationship: inverse_is_a HGNC:7997 ! NRG1 +relationship: inverse_is_a HGNC:7998 ! NRG2 [Term] -id: FPLX:NRG_3_4 +id: FPLX:000320 name: NRG-3-4 synonym: "NRG3-NRG4" EXACT [] synonym: "NRG3/4" EXACT [] xref: BEL:"NRG3/4 Family" -is_a: FPLX:NRG -inverse_is_a: HGNC:NRG3 -inverse_is_a: HGNC:NRG4 +is_a: FPLX:000318 ! NRG +relationship: inverse_is_a HGNC:7999 ! NRG3 +relationship: inverse_is_a HGNC:29862 ! NRG4 [Term] -id: FPLX:NTRK +id: FPLX:000321 name: NTRK synonym: "NTRK" EXACT [] synonym: "NTRKs" EXACT [] @@ -5440,22 +5460,22 @@ xref: BEL:"NTRK Family" xref: IP:IPR020777 xref: IP:IPR031635 xref: MEDSCAN:urn:agi-aopfc:0000278 -is_a: FPLX:root -inverse_is_a: HGNC:NTRK1 -inverse_is_a: HGNC:NTRK2 -inverse_is_a: HGNC:NTRK3 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:8031 ! NTRK1 +relationship: inverse_is_a HGNC:8032 ! NTRK2 +relationship: inverse_is_a HGNC:8033 ! NTRK3 [Term] -id: FPLX:OGT_family +id: FPLX:000322 name: OGT-family -is_a: FPLX:Glycosyltransferase -inverse_is_a: HGNC:EOGT -inverse_is_a: HGNC:OGT -inverse_is_a: HGNC:POMGNT1 -inverse_is_a: HGNC:POMGNT2 +is_a: FPLX:000198 ! Glycosyltransferase +relationship: inverse_is_a HGNC:28526 ! EOGT +relationship: inverse_is_a HGNC:8127 ! OGT +relationship: inverse_is_a HGNC:19139 ! POMGNT1 +relationship: inverse_is_a HGNC:25902 ! POMGNT2 [Term] -id: FPLX:p14_3_3 +id: FPLX:000323 name: p14-3-3 synonym: "14-3-3 proteins" EXACT [] synonym: "14-3-3" EXACT [] @@ -5468,17 +5488,17 @@ xref: XFAM:PF00244 xref: RE:R-HSA-1445138 xref: RE:R-HSA-2457842 xref: SIGNOR:SIGNOR-PF7 -is_a: FPLX:root -inverse_is_a: HGNC:SFN -inverse_is_a: HGNC:YWHAB -inverse_is_a: HGNC:YWHAE -inverse_is_a: HGNC:YWHAG -inverse_is_a: HGNC:YWHAH -inverse_is_a: HGNC:YWHAQ -inverse_is_a: HGNC:YWHAZ +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:10773 ! SFN +relationship: inverse_is_a HGNC:12849 ! YWHAB +relationship: inverse_is_a HGNC:12851 ! YWHAE +relationship: inverse_is_a HGNC:12852 ! YWHAG +relationship: inverse_is_a HGNC:12853 ! YWHAH +relationship: inverse_is_a HGNC:12854 ! YWHAQ +relationship: inverse_is_a HGNC:12855 ! YWHAZ [Term] -id: FPLX:P2RX +id: FPLX:000324 name: P2RX synonym: "P2X purinoreceptor" EXACT [] synonym: "P2X purinoreceptors" EXACT [] @@ -5493,37 +5513,37 @@ xref: NEXTPROT-FAMILY:02630 xref: XFAM:PF00864 xref: RE:R-HSA-139848 xref: RE:R-HSA-8861873 -is_a: FPLX:root -inverse_is_a: HGNC:P2RX1 -inverse_is_a: HGNC:P2RX2 -inverse_is_a: HGNC:P2RX3 -inverse_is_a: HGNC:P2RX4 -inverse_is_a: HGNC:P2RX5 -inverse_is_a: HGNC:P2RX6 -inverse_is_a: HGNC:P2RX7 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:8533 ! P2RX1 +relationship: inverse_is_a HGNC:15459 ! P2RX2 +relationship: inverse_is_a HGNC:8534 ! P2RX3 +relationship: inverse_is_a HGNC:8535 ! P2RX4 +relationship: inverse_is_a HGNC:8536 ! P2RX5 +relationship: inverse_is_a HGNC:8538 ! P2RX6 +relationship: inverse_is_a HGNC:8537 ! P2RX7 [Term] -id: FPLX:P2RY +id: FPLX:000325 name: P2RY synonym: "P2Y receptor" EXACT [] xref: BEL:"P2RY Family" xref: MEDSCAN:urn:agi-protfc:p2y%20receptor -is_a: FPLX:root -inverse_is_a: HGNC:P2RY1 -inverse_is_a: HGNC:P2RY2 -inverse_is_a: HGNC:P2RY4 -inverse_is_a: HGNC:P2RY6 -inverse_is_a: HGNC:P2RY8 -inverse_is_a: HGNC:P2RY10 -inverse_is_a: HGNC:P2RY11 -inverse_is_a: HGNC:P2RY12 -inverse_is_a: HGNC:P2RY13 -inverse_is_a: HGNC:P2RY14 -inverse_is_a: HGNC:LPAR4 -inverse_is_a: HGNC:LPAR6 - -[Term] -id: FPLX:p38 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:8539 ! P2RY1 +relationship: inverse_is_a HGNC:8541 ! P2RY2 +relationship: inverse_is_a HGNC:8542 ! P2RY4 +relationship: inverse_is_a HGNC:8543 ! P2RY6 +relationship: inverse_is_a HGNC:15524 ! P2RY8 +relationship: inverse_is_a HGNC:19906 ! P2RY10 +relationship: inverse_is_a HGNC:8540 ! P2RY11 +relationship: inverse_is_a HGNC:18124 ! P2RY12 +relationship: inverse_is_a HGNC:4537 ! P2RY13 +relationship: inverse_is_a HGNC:16442 ! P2RY14 +relationship: inverse_is_a HGNC:4478 ! LPAR4 +relationship: inverse_is_a HGNC:15520 ! LPAR6 + +[Term] +id: FPLX:000326 name: p38 synonym: "MAPK p38" EXACT [] synonym: "P38 MAPK" EXACT [] @@ -5540,14 +5560,14 @@ xref: RE:R-HSA-1250102 xref: RE:R-HSA-171016 xref: RE:R-HSA-189828 xref: SIGNOR:SIGNOR-PF16 -is_a: FPLX:MAPK -inverse_is_a: HGNC:MAPK11 -inverse_is_a: HGNC:MAPK12 -inverse_is_a: HGNC:MAPK13 -inverse_is_a: HGNC:MAPK14 +is_a: FPLX:000283 ! MAPK +relationship: inverse_is_a HGNC:6873 ! MAPK11 +relationship: inverse_is_a HGNC:6874 ! MAPK12 +relationship: inverse_is_a HGNC:6875 ! MAPK13 +relationship: inverse_is_a HGNC:6876 ! MAPK14 [Term] -id: FPLX:p53_family +id: FPLX:000327 name: p53-family synonym: "P53 family" EXACT [] synonym: "p53 Family" EXACT [] @@ -5560,13 +5580,13 @@ xref: NEXTPROT-FAMILY:02632 xref: XFAM:PF00870 xref: RE:R-HSA-6798076 xref: RE:R-HSA-6798078 -is_a: FPLX:root -inverse_is_a: HGNC:TP53 -inverse_is_a: HGNC:TP63 -inverse_is_a: HGNC:TP73 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:11998 ! TP53 +relationship: inverse_is_a HGNC:15979 ! TP63 +relationship: inverse_is_a HGNC:12003 ! TP73 [Term] -id: FPLX:P70S6K +id: FPLX:000328 name: P70S6K synonym: "p70 S6 kinase" EXACT [] synonym: "P70RSK" EXACT [] @@ -5575,12 +5595,12 @@ synonym: "P70S6K" EXACT [] synonym: "S6K" EXACT [] xref: BEL:"RPS6KB Family" xref: MEDSCAN:urn:agi-protfc:p70rsk -is_a: FPLX:RSK -inverse_is_a: HGNC:RPS6KB1 -inverse_is_a: HGNC:RPS6KB2 +is_a: FPLX:000422 ! RSK +relationship: inverse_is_a HGNC:10436 ! RPS6KB1 +relationship: inverse_is_a HGNC:10437 ! RPS6KB2 [Term] -id: FPLX:P90RSK +id: FPLX:000329 name: P90RSK synonym: "p90RSK" EXACT [] synonym: "RPS6KA" EXACT [] @@ -5589,16 +5609,16 @@ xref: IP:IPR016239 xref: MEDSCAN:urn:agi-protfc:p90rsk xref: RE:R-HSA-446849 xref: SIGNOR:SIGNOR-PF26 -is_a: FPLX:RSK -inverse_is_a: HGNC:RPS6KA1 -inverse_is_a: HGNC:RPS6KA2 -inverse_is_a: HGNC:RPS6KA3 -inverse_is_a: HGNC:RPS6KA4 -inverse_is_a: HGNC:RPS6KA5 -inverse_is_a: HGNC:RPS6KA6 +is_a: FPLX:000422 ! RSK +relationship: inverse_is_a HGNC:10430 ! RPS6KA1 +relationship: inverse_is_a HGNC:10431 ! RPS6KA2 +relationship: inverse_is_a HGNC:10432 ! RPS6KA3 +relationship: inverse_is_a HGNC:10433 ! RPS6KA4 +relationship: inverse_is_a HGNC:10434 ! RPS6KA5 +relationship: inverse_is_a HGNC:10435 ! RPS6KA6 [Term] -id: FPLX:PAK +id: FPLX:000330 name: PAK synonym: "PAK" EXACT [] synonym: "Pak" EXACT [] @@ -5607,42 +5627,42 @@ xref: IP:IPR033923 xref: MEDSCAN:urn:agi-aopfc:0000468 xref: RE:R-HSA-428475 xref: SIGNOR:SIGNOR-PF13 -is_a: FPLX:root -inverse_is_a: HGNC:PAK1 -inverse_is_a: HGNC:PAK2 -inverse_is_a: HGNC:PAK3 -inverse_is_a: HGNC:PAK4 -inverse_is_a: HGNC:PAK5 -inverse_is_a: HGNC:PAK6 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:8590 ! PAK1 +relationship: inverse_is_a HGNC:8591 ! PAK2 +relationship: inverse_is_a HGNC:8592 ! PAK3 +relationship: inverse_is_a HGNC:16059 ! PAK4 +relationship: inverse_is_a HGNC:15916 ! PAK5 +relationship: inverse_is_a HGNC:16061 ! PAK6 [Term] -id: FPLX:PARP +id: FPLX:000331 name: PARP synonym: "PARP genes" EXACT [] synonym: "PARPs" EXACT [] synonym: "Poly(ADP-ribose) polymerase" EXACT [] synonym: "Poly(ADP-ribose) polymerases" EXACT [] xref: XFAM:PF00644 -is_a: FPLX:root -inverse_is_a: HGNC:PARP1 -inverse_is_a: HGNC:PARP2 -inverse_is_a: HGNC:PARP3 -inverse_is_a: HGNC:PARP4 -inverse_is_a: HGNC:PARP6 -inverse_is_a: HGNC:PARP8 -inverse_is_a: HGNC:PARP9 -inverse_is_a: HGNC:PARP10 -inverse_is_a: HGNC:PARP11 -inverse_is_a: HGNC:PARP12 -inverse_is_a: HGNC:PARP14 -inverse_is_a: HGNC:PARP15 -inverse_is_a: HGNC:PARP16 -inverse_is_a: HGNC:TNKS -inverse_is_a: HGNC:TNKS2 -inverse_is_a: HGNC:TIPARP - -[Term] -id: FPLX:PARV +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:270 ! PARP1 +relationship: inverse_is_a HGNC:272 ! PARP2 +relationship: inverse_is_a HGNC:273 ! PARP3 +relationship: inverse_is_a HGNC:271 ! PARP4 +relationship: inverse_is_a HGNC:26921 ! PARP6 +relationship: inverse_is_a HGNC:26124 ! PARP8 +relationship: inverse_is_a HGNC:24118 ! PARP9 +relationship: inverse_is_a HGNC:25895 ! PARP10 +relationship: inverse_is_a HGNC:1186 ! PARP11 +relationship: inverse_is_a HGNC:21919 ! PARP12 +relationship: inverse_is_a HGNC:29232 ! PARP14 +relationship: inverse_is_a HGNC:26876 ! PARP15 +relationship: inverse_is_a HGNC:26040 ! PARP16 +relationship: inverse_is_a HGNC:11941 ! TNKS +relationship: inverse_is_a HGNC:15677 ! TNKS2 +relationship: inverse_is_a HGNC:23696 ! TIPARP + +[Term] +id: FPLX:000332 name: PARV synonym: "Parvin" EXACT [] synonym: "parvin" EXACT [] @@ -5651,13 +5671,13 @@ synonym: "parvins" EXACT [] xref: BEL:"PARV Family" xref: IP:IPR028433 xref: NEXTPROT-FAMILY:02660 -is_a: FPLX:root -inverse_is_a: HGNC:PARVA -inverse_is_a: HGNC:PARVB -inverse_is_a: HGNC:PARVG +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:14652 ! PARVA +relationship: inverse_is_a HGNC:14653 ! PARVB +relationship: inverse_is_a HGNC:14654 ! PARVG [Term] -id: FPLX:Patched +id: FPLX:000333 name: Patched synonym: "PATCHED" EXACT [] synonym: "Patched" EXACT [] @@ -5665,12 +5685,12 @@ xref: IP:IPR004766 xref: MEDSCAN:urn:agi-aopfc:0000281 xref: XFAM:PF02460 xref: RE:R-HSA-445134 -is_a: FPLX:root -inverse_is_a: HGNC:PTCH1 -inverse_is_a: HGNC:PTCH2 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:9585 ! PTCH1 +relationship: inverse_is_a HGNC:9586 ! PTCH2 [Term] -id: FPLX:PBX +id: FPLX:000334 name: PBX synonym: "PBX" EXACT [] synonym: "Pbx" EXACT [] @@ -5678,14 +5698,14 @@ synonym: "pbx" EXACT [] synonym: "PBXs" EXACT [] xref: BEL:"PBX Family" xref: IP:IPR005542 -is_a: FPLX:root -inverse_is_a: HGNC:PBX1 -inverse_is_a: HGNC:PBX2 -inverse_is_a: HGNC:PBX3 -inverse_is_a: HGNC:PBX4 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:8632 ! PBX1 +relationship: inverse_is_a HGNC:8633 ! PBX2 +relationship: inverse_is_a HGNC:8634 ! PBX3 +relationship: inverse_is_a HGNC:13403 ! PBX4 [Term] -id: FPLX:PDE +id: FPLX:000335 name: PDE synonym: "PDE" EXACT [] synonym: "PDEs" EXACT [] @@ -5695,20 +5715,20 @@ synonym: "Phosphodiesterases" EXACT [] synonym: "phosphodiesterases" EXACT [] xref: BEL:"PDE Family" xref: ECCODE:3.1.4.- -is_a: FPLX:root -inverse_is_a: HGNC:PDE2A -inverse_is_a: HGNC:PDE9A -inverse_is_a: HGNC:PDE10A -inverse_is_a: HGNC:PDE11A -inverse_is_a: FPLX:PDE1 -inverse_is_a: FPLX:PDE3 -inverse_is_a: FPLX:PDE4 -inverse_is_a: FPLX:PDE6 -inverse_is_a: FPLX:PDE7 -inverse_is_a: FPLX:PDE8 - -[Term] -id: FPLX:PDE1 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:8777 ! PDE2A +relationship: inverse_is_a HGNC:8795 ! PDE9A +relationship: inverse_is_a HGNC:8772 ! PDE10A +relationship: inverse_is_a HGNC:8773 ! PDE11A +relationship: inverse_is_a FPLX:000336 ! PDE1 +relationship: inverse_is_a FPLX:000337 ! PDE3 +relationship: inverse_is_a FPLX:000338 ! PDE4 +relationship: inverse_is_a FPLX:000339 ! PDE6 +relationship: inverse_is_a FPLX:000340 ! PDE7 +relationship: inverse_is_a FPLX:000341 ! PDE8 + +[Term] +id: FPLX:000336 name: PDE1 synonym: "PDE1 family" EXACT [] synonym: "PDE1" EXACT [] @@ -5721,13 +5741,13 @@ xref: GO:0004117 xref: IP:IPR013706 xref: RE:R-HSA-111952 xref: RE:R-HSA-111953 -is_a: FPLX:PDE -inverse_is_a: HGNC:PDE1A -inverse_is_a: HGNC:PDE1B -inverse_is_a: HGNC:PDE1C +is_a: FPLX:000335 ! PDE +relationship: inverse_is_a HGNC:8774 ! PDE1A +relationship: inverse_is_a HGNC:8775 ! PDE1B +relationship: inverse_is_a HGNC:8776 ! PDE1C [Term] -id: FPLX:PDE3 +id: FPLX:000337 name: PDE3 synonym: "PDE 3" EXACT [] synonym: "PDE3 family" EXACT [] @@ -5739,12 +5759,12 @@ synonym: "phosphodiesterase-3" EXACT [] xref: BEL:"PDE3 Family" xref: MEDSCAN:urn:agi-protfc:phosphodiesterase%20III xref: NEXTPROT-FAMILY:00803 -is_a: FPLX:PDE -inverse_is_a: HGNC:PDE3A -inverse_is_a: HGNC:PDE3B +is_a: FPLX:000335 ! PDE +relationship: inverse_is_a HGNC:8778 ! PDE3A +relationship: inverse_is_a HGNC:8779 ! PDE3B [Term] -id: FPLX:PDE4 +id: FPLX:000338 name: PDE4 synonym: "PDE4 family" EXACT [] synonym: "PDE4 isoforms" EXACT [] @@ -5759,14 +5779,14 @@ xref: MEDSCAN:urn:agi-protfc:PDE4%20subfamily xref: NCIT:C107433 xref: NEXTPROT-FAMILY:00804 xref: RE:R-HSA-111960 -is_a: FPLX:PDE -inverse_is_a: HGNC:PDE4A -inverse_is_a: HGNC:PDE4B -inverse_is_a: HGNC:PDE4C -inverse_is_a: HGNC:PDE4D +is_a: FPLX:000335 ! PDE +relationship: inverse_is_a HGNC:8780 ! PDE4A +relationship: inverse_is_a HGNC:8781 ! PDE4B +relationship: inverse_is_a HGNC:8782 ! PDE4C +relationship: inverse_is_a HGNC:8783 ! PDE4D [Term] -id: FPLX:PDE6 +id: FPLX:000339 name: PDE6 synonym: "PDE6 family" EXACT [] synonym: "PDE6" EXACT [] @@ -5776,13 +5796,13 @@ synonym: "Phosphodiesterase-6" EXACT [] synonym: "phosphodiesterase-6" EXACT [] xref: BEL:"PDE6 Family" xref: MEDSCAN:urn:agi-aopfc:0000704 -is_a: FPLX:PDE -inverse_is_a: HGNC:PDE6A -inverse_is_a: HGNC:PDE6B -inverse_is_a: HGNC:PDE6C +is_a: FPLX:000335 ! PDE +relationship: inverse_is_a HGNC:8785 ! PDE6A +relationship: inverse_is_a HGNC:8786 ! PDE6B +relationship: inverse_is_a HGNC:8787 ! PDE6C [Term] -id: FPLX:PDE7 +id: FPLX:000340 name: PDE7 synonym: "PDE7" EXACT [] synonym: "Phosphodiesterase 7" EXACT [] @@ -5790,12 +5810,12 @@ synonym: "phosphodiesterase 7" EXACT [] synonym: "Phosphodiesterase-7" EXACT [] synonym: "phosphodiesterase-7" EXACT [] xref: RE:R-HSA-418540 -is_a: FPLX:PDE -inverse_is_a: HGNC:PDE7A -inverse_is_a: HGNC:PDE7B +is_a: FPLX:000335 ! PDE +relationship: inverse_is_a HGNC:8791 ! PDE7A +relationship: inverse_is_a HGNC:8792 ! PDE7B [Term] -id: FPLX:PDE8 +id: FPLX:000341 name: PDE8 synonym: "PDE8" EXACT [] synonym: "Phosphodiesterase 8" EXACT [] @@ -5803,12 +5823,12 @@ synonym: "phosphodiesterase 8" EXACT [] synonym: "Phosphodiesterase-8" EXACT [] synonym: "phosphodiesterase-8" EXACT [] xref: RE:R-HSA-418541 -is_a: FPLX:PDE -inverse_is_a: HGNC:PDE8A -inverse_is_a: HGNC:PDE8B +is_a: FPLX:000335 ! PDE +relationship: inverse_is_a HGNC:8793 ! PDE8A +relationship: inverse_is_a HGNC:8794 ! PDE8B [Term] -id: FPLX:PDGF +id: FPLX:000342 name: PDGF synonym: "PDGF" EXACT [] xref: BEL:"PDGF Family" @@ -5816,14 +5836,14 @@ xref: GO:0005161 xref: NCIT:C20448 xref: RE:R-HSA-381926 xref: RE:R-HSA-381936 -is_a: FPLX:root -inverse_is_a: HGNC:PDGFA -inverse_is_a: HGNC:PDGFB -inverse_is_a: HGNC:PDGFC -inverse_is_a: HGNC:PDGFD +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:8799 ! PDGFA +relationship: inverse_is_a HGNC:8800 ! PDGFB +relationship: inverse_is_a HGNC:8801 ! PDGFC +relationship: inverse_is_a HGNC:30620 ! PDGFD [Term] -id: FPLX:PDGFR +id: FPLX:000343 name: PDGFR synonym: "PDGFR" EXACT [] xref: BEL:"PDGFR Family" @@ -5834,12 +5854,12 @@ xref: RE:R-HSA-186791 xref: RE:R-HSA-186792 xref: RE:R-HSA-186821 xref: RE:R-HSA-8864040 -is_a: FPLX:root -inverse_is_a: HGNC:PDGFRA -inverse_is_a: HGNC:PDGFRB +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:8803 ! PDGFRA +relationship: inverse_is_a HGNC:8804 ! PDGFRB [Term] -id: FPLX:PDGFR_AA +id: FPLX:000344 name: PDGFR-AA synonym: "PDGFR-AA" EXACT [] synonym: "PDGFR-alphaalpha" EXACT [] @@ -5849,11 +5869,11 @@ synonym: "PDGFRαα" EXACT [] xref: IP:IPR027290 xref: RE:R-HSA-186816 xref: RE:R-HSA-186817 -is_a: FPLX:root -has_part: HGNC:PDGFRA +is_a: FPLX:000000 ! famplex +relationship: has_part HGNC:8803 ! PDGFRA [Term] -id: FPLX:PDGFR_AB +id: FPLX:000345 name: PDGFR-AB synonym: "PDGFR-AB" EXACT [] synonym: "PDGFR-alphabeta" EXACT [] @@ -5866,12 +5886,12 @@ xref: RE:R-HSA-186791 xref: RE:R-HSA-186792 xref: RE:R-HSA-186821 xref: RE:R-HSA-8864040 -is_a: FPLX:root -has_part: HGNC:PDGFRA -has_part: HGNC:PDGFRB +is_a: FPLX:000000 ! famplex +relationship: has_part HGNC:8803 ! PDGFRA +relationship: has_part HGNC:8804 ! PDGFRB [Term] -id: FPLX:PDGFR_BB +id: FPLX:000346 name: PDGFR-BB synonym: "PDGFR-BB" EXACT [] synonym: "PDGFR-betabeta" EXACT [] @@ -5882,34 +5902,34 @@ xref: IP:IPR027288 xref: RE:R-HSA-186799 xref: RE:R-HSA-186805 xref: RE:R-HSA-8864046 -is_a: FPLX:root -has_part: HGNC:PDGFRB +is_a: FPLX:000000 ! famplex +relationship: has_part HGNC:8804 ! PDGFRB [Term] -id: FPLX:PDGF_AA +id: FPLX:000347 name: PDGF-AA synonym: "PDGF-AA" EXACT [] synonym: "PDGF-aa" EXACT [] synonym: "PDGFAA" EXACT [] xref: MEDSCAN:urn:agi-complex:platelet%20derived%20growth%20factor%20AA xref: RE:R-HSA-184203 -is_a: FPLX:root -has_part: HGNC:PDGFA +is_a: FPLX:000000 ! famplex +relationship: has_part HGNC:8799 ! PDGFA [Term] -id: FPLX:PDGF_AB +id: FPLX:000348 name: PDGF-AB synonym: "PDGF-AB" EXACT [] synonym: "PDGF-ab" EXACT [] synonym: "PDGFAB" EXACT [] xref: MEDSCAN:urn:agi-complex:platelet%20derived%20growth%20factor%20AB xref: RE:R-HSA-380759 -is_a: FPLX:root -has_part: HGNC:PDGFA -has_part: HGNC:PDGFB +is_a: FPLX:000000 ! famplex +relationship: has_part HGNC:8799 ! PDGFA +relationship: has_part HGNC:8800 ! PDGFB [Term] -id: FPLX:PDGF_BB +id: FPLX:000349 name: PDGF-BB synonym: "PDGF-BB" EXACT [] synonym: "PDGF-bb" EXACT [] @@ -5929,45 +5949,45 @@ xref: RE:R-HSA-381935 xref: RE:R-HSA-381938 xref: RE:R-HSA-387074 xref: RE:R-HSA-392712 -is_a: FPLX:root -has_part: HGNC:PDGFB +is_a: FPLX:000000 ! famplex +relationship: has_part HGNC:8800 ! PDGFB [Term] -id: FPLX:PDGF_CC +id: FPLX:000350 name: PDGF-CC synonym: "PDGF CC" EXACT [] synonym: "PDGF-CC" EXACT [] synonym: "PDGF-cc" EXACT [] xref: RE:R-HSA-381941 -is_a: FPLX:root -has_part: HGNC:PDGFC +is_a: FPLX:000000 ! famplex +relationship: has_part HGNC:8801 ! PDGFC [Term] -id: FPLX:PDGF_DD +id: FPLX:000351 name: PDGF-DD synonym: "PDGF DD" EXACT [] synonym: "PDGF-DD" EXACT [] synonym: "PDGF-dd" EXACT [] xref: RE:R-HSA-381930 -is_a: FPLX:root -has_part: HGNC:PDGFD +is_a: FPLX:000000 ! famplex +relationship: has_part HGNC:30620 ! PDGFD [Term] -id: FPLX:PDH +id: FPLX:000352 name: PDH synonym: "PDH" EXACT [] synonym: "pyruvate dehydrogenase (acetyl-transferring)" EXACT [] xref: BEL:"Pyruvate Dehydrogenase Complex" -is_a: FPLX:root -has_part: HGNC:DLAT -has_part: HGNC:DLD -has_part: HGNC:PDHA1 -has_part: HGNC:PDHA2 -has_part: HGNC:PDHB -has_part: HGNC:PDHX +is_a: FPLX:000000 ! famplex +relationship: has_part HGNC:2896 ! DLAT +relationship: has_part HGNC:2898 ! DLD +relationship: has_part HGNC:8806 ! PDHA1 +relationship: has_part HGNC:8807 ! PDHA2 +relationship: has_part HGNC:8808 ! PDHB +relationship: has_part HGNC:21350 ! PDHX [Term] -id: FPLX:PDK +id: FPLX:000353 name: PDK synonym: "PDK" EXACT [] synonym: "PDKs" EXACT [] @@ -5976,23 +5996,23 @@ synonym: "pyruvate dehydrogenase kinase" EXACT [] xref: BEL:"PDK Family" xref: ECCODE:1.2.4.1 xref: RE:R-HSA-203947 -is_a: FPLX:root -inverse_is_a: HGNC:PDK1 -inverse_is_a: HGNC:PDK2 -inverse_is_a: HGNC:PDK3 -inverse_is_a: HGNC:PDK4 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:8809 ! PDK1 +relationship: inverse_is_a HGNC:8810 ! PDK2 +relationship: inverse_is_a HGNC:8811 ! PDK3 +relationship: inverse_is_a HGNC:8812 ! PDK4 [Term] -id: FPLX:Pertussis_toxin +id: FPLX:000354 name: Pertussis-toxin synonym: "Pertussis toxin" EXACT [] synonym: "pertussis toxin" EXACT [] synonym: "PTX" EXACT [] xref: NCIT:C736 -is_a: FPLX:root +is_a: FPLX:000000 ! famplex [Term] -id: FPLX:PFN +id: FPLX:000355 name: PFN synonym: "Profilin" EXACT [] synonym: "profilin" EXACT [] @@ -6002,38 +6022,38 @@ xref: BEL:"PFN Family" xref: IP:IPR005455 xref: MEDSCAN:urn:agi-protfc:profilin xref: XFAM:PF00235 -is_a: FPLX:root -inverse_is_a: HGNC:PFN1 -inverse_is_a: HGNC:PFN2 -inverse_is_a: HGNC:PFN3 -inverse_is_a: HGNC:PFN4 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:8881 ! PFN1 +relationship: inverse_is_a HGNC:8882 ! PFN2 +relationship: inverse_is_a HGNC:18627 ! PFN3 +relationship: inverse_is_a HGNC:31103 ! PFN4 [Term] -id: FPLX:PhK +id: FPLX:000356 name: PhK synonym: "PhK" EXACT [] synonym: "Phosphorylase kinase" EXACT [] synonym: "phosphorylase kinase" EXACT [] xref: BEL:"Phosphorylase B Kinase Complex" xref: ECCODE:2.7.11.19 -is_a: FPLX:root -has_part: HGNC:CALM1 -has_part: HGNC:PHKA1 -has_part: HGNC:PHKA2 -has_part: HGNC:PHKB -has_part: HGNC:PHKG1 -has_part: HGNC:PHKG2 +is_a: FPLX:000000 ! famplex +relationship: has_part HGNC:1442 ! CALM1 +relationship: has_part HGNC:8925 ! PHKA1 +relationship: has_part HGNC:8926 ! PHKA2 +relationship: has_part HGNC:8927 ! PHKB +relationship: has_part HGNC:8930 ! PHKG1 +relationship: has_part HGNC:8931 ! PHKG2 [Term] -id: FPLX:Phosphatase +id: FPLX:000357 name: Phosphatase synonym: "phosphatase" EXACT [] xref: MESH:D010749 xref: NCIT:C16981 -is_a: FPLX:root +is_a: FPLX:000000 ! famplex [Term] -id: FPLX:PI3K +id: FPLX:000358 name: PI3K synonym: "phosphatidylinositol 3-kinase" EXACT [] synonym: "PI 3-kinase" EXACT [] @@ -6045,59 +6065,59 @@ xref: BEL:"p85/p110 PI3Kinase Complex" xref: MEDSCAN:urn:agi-aopfc:0000447 xref: MEDSCAN:urn:agi-complex:prophash-285b9ff3749679e4d6266406a20973aa xref: NCIT:C17270 -is_a: FPLX:root -has_part: FPLX:PI3K_p110 -has_part: FPLX:PIK3R_I +is_a: FPLX:000000 ! famplex +relationship: has_part FPLX:000359 ! PI3K_p110 +relationship: has_part FPLX:000361 ! PIK3R_I [Term] -id: FPLX:PI3K_p110 +id: FPLX:000359 name: PI3K-p110 synonym: "p110" EXACT [] synonym: "PI3K p110 subunit" EXACT [] synonym: "PIK3C" EXACT [] xref: BEL:"PIK3C Class IA Family" xref: IP:IPR003113 -part_of: FPLX:PI3K -inverse_is_a: HGNC:PIK3CA -inverse_is_a: HGNC:PIK3CB -inverse_is_a: HGNC:PIK3CD -inverse_is_a: HGNC:PIK3CG +relationship: part_of FPLX:000358 ! PI3K +relationship: inverse_is_a HGNC:8975 ! PIK3CA +relationship: inverse_is_a HGNC:8976 ! PIK3CB +relationship: inverse_is_a HGNC:8977 ! PIK3CD +relationship: inverse_is_a HGNC:8978 ! PIK3CG [Term] -id: FPLX:PI3K_p85 +id: FPLX:000360 name: PI3K-p85 synonym: "p85" EXACT [] xref: RE:R-HSA-74688 -is_a: FPLX:PIK3R_I -inverse_is_a: HGNC:PIK3R1 -inverse_is_a: HGNC:PIK3R2 +is_a: FPLX:000361 ! PIK3R_I +relationship: inverse_is_a HGNC:8979 ! PIK3R1 +relationship: inverse_is_a HGNC:8980 ! PIK3R2 [Term] -id: FPLX:PIK3R_I +id: FPLX:000361 name: PIK3R-I synonym: "PIK3R" EXACT [] xref: BEL:"PIK3R Class IA Family" -part_of: FPLX:PI3K -inverse_is_a: HGNC:PIK3R3 -inverse_is_a: HGNC:PIK3R4 -inverse_is_a: HGNC:PIK3R5 -inverse_is_a: HGNC:PIK3R6 -inverse_is_a: FPLX:PI3K_p85 +relationship: part_of FPLX:000358 ! PI3K +relationship: inverse_is_a HGNC:8981 ! PIK3R3 +relationship: inverse_is_a HGNC:8982 ! PIK3R4 +relationship: inverse_is_a HGNC:30035 ! PIK3R5 +relationship: inverse_is_a HGNC:27101 ! PIK3R6 +relationship: inverse_is_a FPLX:000360 ! PI3K_p85 [Term] -id: FPLX:PIM +id: FPLX:000362 name: PIM synonym: "PIM" EXACT [] xref: IP:IPR017348 xref: NEXTPROT-FAMILY:03078 xref: SIGNOR:SIGNOR-PF34 -is_a: FPLX:root -inverse_is_a: HGNC:PIM1 -inverse_is_a: HGNC:PIM2 -inverse_is_a: HGNC:PIM3 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:8986 ! PIM1 +relationship: inverse_is_a HGNC:8987 ! PIM2 +relationship: inverse_is_a HGNC:19310 ! PIM3 [Term] -id: FPLX:PKA +id: FPLX:000363 name: PKA synonym: "cAMP-dependent PK" EXACT [] synonym: "cAMP-dependent protein kinase" EXACT [] @@ -6108,12 +6128,12 @@ synonym: "PKA" EXACT [] synonym: "protein kinase A" EXACT [] xref: ECCODE:2.7.11.11 xref: NCIT:C16479 -is_a: FPLX:root -has_part: FPLX:PRKAR -has_part: FPLX:PRKAC +is_a: FPLX:000000 ! famplex +relationship: has_part FPLX:000390 ! PRKAR +relationship: has_part FPLX:000389 ! PRKAC [Term] -id: FPLX:PKC +id: FPLX:000364 name: PKC synonym: "PKC" EXACT [] synonym: "protein kinase C" EXACT [] @@ -6123,32 +6143,32 @@ xref: IP:IPR012233 xref: MESH:D011493 xref: NCIT:C17017 xref: NEXTPROT-FAMILY:03065 -is_a: FPLX:root -inverse_is_a: HGNC:PRKCA -inverse_is_a: HGNC:PRKCB -inverse_is_a: HGNC:PRKCD -inverse_is_a: HGNC:PRKCE -inverse_is_a: HGNC:PRKCG -inverse_is_a: HGNC:PRKCH -inverse_is_a: HGNC:PRKCI -inverse_is_a: HGNC:PRKCQ -inverse_is_a: HGNC:PRKCZ -inverse_is_a: HGNC:PRKD3 - -[Term] -id: FPLX:PKI +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:9393 ! PRKCA +relationship: inverse_is_a HGNC:9395 ! PRKCB +relationship: inverse_is_a HGNC:9399 ! PRKCD +relationship: inverse_is_a HGNC:9401 ! PRKCE +relationship: inverse_is_a HGNC:9402 ! PRKCG +relationship: inverse_is_a HGNC:9403 ! PRKCH +relationship: inverse_is_a HGNC:9404 ! PRKCI +relationship: inverse_is_a HGNC:9410 ! PRKCQ +relationship: inverse_is_a HGNC:9412 ! PRKCZ +relationship: inverse_is_a HGNC:9408 ! PRKD3 + +[Term] +id: FPLX:000365 name: PKI synonym: "PKI" EXACT [] xref: BEL:"PKI Family" xref: IP:IPR004171 xref: XFAM:PF02827 -is_a: FPLX:root -inverse_is_a: HGNC:PKIA -inverse_is_a: HGNC:PKIB -inverse_is_a: HGNC:PKIG +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:9017 ! PKIA +relationship: inverse_is_a HGNC:9018 ! PKIB +relationship: inverse_is_a HGNC:9019 ! PKIG [Term] -id: FPLX:PLA2 +id: FPLX:000366 name: PLA2 synonym: "cPLA2" EXACT [] synonym: "cytosolic phospholipase A(2)" EXACT [] @@ -6161,20 +6181,20 @@ xref: MEDSCAN:urn:agi-aopfc:0000455 xref: MEDSCAN:urn:agi-protfc:cytosolic%20phospholipase%20a2 xref: NCIT:C16979 xref: NEXTPROT-FAMILY:02840 -is_a: FPLX:root -inverse_is_a: HGNC:PLA2G1B -inverse_is_a: HGNC:PLA2G3 -inverse_is_a: HGNC:PLA2G5 -inverse_is_a: HGNC:PLA2G6 -inverse_is_a: HGNC:PLA2G7 -inverse_is_a: HGNC:PLA2G10 -inverse_is_a: HGNC:PLA2G12A -inverse_is_a: HGNC:PLA2G12B -inverse_is_a: FPLX:PLA2G2 -inverse_is_a: FPLX:PLA2G4 - -[Term] -id: FPLX:PLA2G2 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:9030 ! PLA2G1B +relationship: inverse_is_a HGNC:17934 ! PLA2G3 +relationship: inverse_is_a HGNC:9038 ! PLA2G5 +relationship: inverse_is_a HGNC:9039 ! PLA2G6 +relationship: inverse_is_a HGNC:9040 ! PLA2G7 +relationship: inverse_is_a HGNC:9029 ! PLA2G10 +relationship: inverse_is_a HGNC:18554 ! PLA2G12A +relationship: inverse_is_a HGNC:18555 ! PLA2G12B +relationship: inverse_is_a FPLX:000367 ! PLA2G2 +relationship: inverse_is_a FPLX:000368 ! PLA2G4 + +[Term] +id: FPLX:000367 name: PLA2G2 synonym: "GII PLA2" EXACT [] synonym: "GIIPLA2" EXACT [] @@ -6182,15 +6202,15 @@ synonym: "phospholipase A2 group-II" EXACT [] synonym: "PLA2G2" EXACT [] synonym: "PLA2g2" EXACT [] xref: BEL:"PLA2G2 Family" -is_a: FPLX:PLA2 -inverse_is_a: HGNC:PLA2G2A -inverse_is_a: HGNC:PLA2G2C -inverse_is_a: HGNC:PLA2G2D -inverse_is_a: HGNC:PLA2G2E -inverse_is_a: HGNC:PLA2G2F +is_a: FPLX:000366 ! PLA2 +relationship: inverse_is_a HGNC:9031 ! PLA2G2A +relationship: inverse_is_a HGNC:9032 ! PLA2G2C +relationship: inverse_is_a HGNC:9033 ! PLA2G2D +relationship: inverse_is_a HGNC:13414 ! PLA2G2E +relationship: inverse_is_a HGNC:30040 ! PLA2G2F [Term] -id: FPLX:PLA2G4 +id: FPLX:000368 name: PLA2G4 synonym: "gIV-PLA(2)" EXACT [] synonym: "group IV-PLA(2)" EXACT [] @@ -6198,13 +6218,13 @@ synonym: "Phospholipase A2 Group IV" EXACT [] synonym: "phospholipase A2 group-IV" EXACT [] synonym: "PLA2G4" EXACT [] xref: NCIT:C19836 -is_a: FPLX:PLA2 -inverse_is_a: HGNC:PLA2G4A -inverse_is_a: HGNC:PLA2G4C -inverse_is_a: HGNC:PLA2G4D +is_a: FPLX:000366 ! PLA2 +relationship: inverse_is_a HGNC:9035 ! PLA2G4A +relationship: inverse_is_a HGNC:9037 ! PLA2G4C +relationship: inverse_is_a HGNC:30038 ! PLA2G4D [Term] -id: FPLX:PLC +id: FPLX:000369 name: PLC synonym: "Phospholipase C" EXACT [] synonym: "phospholipase C" EXACT [] @@ -6212,15 +6232,15 @@ synonym: "Phospholipase-C" EXACT [] synonym: "phospholipase-C" EXACT [] synonym: "PLC" EXACT [] xref: BEL:"PLC Family" -is_a: FPLX:root -inverse_is_a: HGNC:PLCE1 -inverse_is_a: HGNC:PLCZ1 -inverse_is_a: FPLX:PLCB -inverse_is_a: FPLX:PLCD -inverse_is_a: FPLX:PLCG +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:17175 ! PLCE1 +relationship: inverse_is_a HGNC:19218 ! PLCZ1 +relationship: inverse_is_a FPLX:000370 ! PLCB +relationship: inverse_is_a FPLX:000371 ! PLCD +relationship: inverse_is_a FPLX:000372 ! PLCG [Term] -id: FPLX:PLCB +id: FPLX:000370 name: PLCB synonym: "Phospholipase C-beta" EXACT [] synonym: "phospholipase C-beta" EXACT [] @@ -6233,14 +6253,14 @@ synonym: "phospholipase Cβ" EXACT [] xref: BEL:"PLCB Family" xref: IP:IPR016280 xref: RE:R-HSA-111854 -is_a: FPLX:PLC -inverse_is_a: HGNC:PLCB1 -inverse_is_a: HGNC:PLCB2 -inverse_is_a: HGNC:PLCB3 -inverse_is_a: HGNC:PLCB4 +is_a: FPLX:000369 ! PLC +relationship: inverse_is_a HGNC:15917 ! PLCB1 +relationship: inverse_is_a HGNC:9055 ! PLCB2 +relationship: inverse_is_a HGNC:9056 ! PLCB3 +relationship: inverse_is_a HGNC:9059 ! PLCB4 [Term] -id: FPLX:PLCD +id: FPLX:000371 name: PLCD synonym: "Phospholipase C-delta" EXACT [] synonym: "phospholipase C-delta" EXACT [] @@ -6250,13 +6270,13 @@ synonym: "Phospholipase Cdelta" EXACT [] synonym: "phospholipase Cdelta" EXACT [] synonym: "Phospholipase Cδ" EXACT [] synonym: "phospholipase Cδ" EXACT [] -is_a: FPLX:PLC -inverse_is_a: HGNC:PLCD1 -inverse_is_a: HGNC:PLCD3 -inverse_is_a: HGNC:PLCD4 +is_a: FPLX:000369 ! PLC +relationship: inverse_is_a HGNC:9060 ! PLCD1 +relationship: inverse_is_a HGNC:9061 ! PLCD3 +relationship: inverse_is_a HGNC:9062 ! PLCD4 [Term] -id: FPLX:PLCG +id: FPLX:000372 name: PLCG synonym: "PLC-gamma" EXACT [] synonym: "PLC-γ" EXACT [] @@ -6270,28 +6290,28 @@ xref: RE:R-HSA-1169086 xref: RE:R-HSA-1169089 xref: RE:R-HSA-2029095 xref: RE:R-HSA-2685653 -is_a: FPLX:PLC -inverse_is_a: HGNC:PLCG1 -inverse_is_a: HGNC:PLCG2 +is_a: FPLX:000369 ! PLC +relationship: inverse_is_a HGNC:9065 ! PLCG1 +relationship: inverse_is_a HGNC:9066 ! PLCG2 [Term] -id: FPLX:PLD +id: FPLX:000373 name: PLD synonym: "Phospholipase D" EXACT [] synonym: "phospholipase D" EXACT [] xref: BEL:"PLD Family" xref: ECCODE:3.1.4.4 xref: IP:IPR015679 -is_a: FPLX:root -inverse_is_a: HGNC:PLD1 -inverse_is_a: HGNC:PLD2 -inverse_is_a: HGNC:PLD3 -inverse_is_a: HGNC:PLD4 -inverse_is_a: HGNC:PLD5 -inverse_is_a: HGNC:PLD6 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:9067 ! PLD1 +relationship: inverse_is_a HGNC:9068 ! PLD2 +relationship: inverse_is_a HGNC:17158 ! PLD3 +relationship: inverse_is_a HGNC:23792 ! PLD4 +relationship: inverse_is_a HGNC:26879 ! PLD5 +relationship: inverse_is_a HGNC:30447 ! PLD6 [Term] -id: FPLX:PPAP2 +id: FPLX:000374 name: PPAP2 synonym: "type 2 phosphatidic acid phosphatase" EXACT [] synonym: "type 2 phosphatidic acid phosphatases" EXACT [] @@ -6299,25 +6319,25 @@ synonym: "type II phosphatidic acid phosphatase" EXACT [] synonym: "type II phosphatidic acid phosphatases" EXACT [] xref: BEL:"PPAP2 Family" xref: RE:R-HSA-428110 -is_a: FPLX:root -inverse_is_a: HGNC:PLPP1 -inverse_is_a: HGNC:PLPP2 -inverse_is_a: HGNC:PLPP3 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:9228 ! PLPP1 +relationship: inverse_is_a HGNC:9230 ! PLPP2 +relationship: inverse_is_a HGNC:9229 ! PLPP3 [Term] -id: FPLX:PPAR +id: FPLX:000375 name: PPAR synonym: "PPAR" EXACT [] xref: BEL:"PPAR Family" xref: IP:IPR003074 xref: MEDSCAN:urn:agi-protfc:ppar -is_a: FPLX:root -inverse_is_a: HGNC:PPARA -inverse_is_a: HGNC:PPARD -inverse_is_a: HGNC:PPARG +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:9232 ! PPARA +relationship: inverse_is_a HGNC:9235 ! PPARD +relationship: inverse_is_a HGNC:9236 ! PPARG [Term] -id: FPLX:PPP1 +id: FPLX:000376 name: PPP1 synonym: "PP1 regulator" EXACT [] synonym: "PP1" EXACT [] @@ -6326,12 +6346,12 @@ xref: GO:0008599 xref: MEDSCAN:urn:agi-complex:prophash-d39afef40daf23ad8376b53904c7092c xref: MEDSCAN:urn:agi-complex:protein%20phosphatase%20type%201%20complex xref: NEXTPROT-FAMILY:03001 -is_a: FPLX:root -has_part: FPLX:PPP1C -has_part: FPLX:PPP1R +is_a: FPLX:000000 ! famplex +relationship: has_part FPLX:000377 ! PPP1C +relationship: has_part FPLX:000378 ! PPP1R [Term] -id: FPLX:PPP1C +id: FPLX:000377 name: PPP1C synonym: "PP1C" EXACT [] synonym: "PP1c" EXACT [] @@ -6339,48 +6359,48 @@ synonym: "PPP1C" EXACT [] xref: BEL:"PPP1C Family" xref: IP:IPR031675 xref: RE:R-HSA-163538 -part_of: FPLX:PPP1 -inverse_is_a: HGNC:PPP1CA -inverse_is_a: HGNC:PPP1CB -inverse_is_a: HGNC:PPP1CC +relationship: part_of FPLX:000376 ! PPP1 +relationship: inverse_is_a HGNC:9281 ! PPP1CA +relationship: inverse_is_a HGNC:9282 ! PPP1CB +relationship: inverse_is_a HGNC:9283 ! PPP1CC [Term] -id: FPLX:PPP1R +id: FPLX:000378 name: PPP1R synonym: "PP1R" EXACT [] synonym: "PP1r" EXACT [] xref: BEL:"PPP1R Family" -part_of: FPLX:PPP1 -inverse_is_a: HGNC:PPP1R10 -inverse_is_a: HGNC:PPP1R11 -inverse_is_a: HGNC:PPP1R12A -inverse_is_a: HGNC:PPP1R12B -inverse_is_a: HGNC:PPP1R12C -inverse_is_a: HGNC:PPP1R13B -inverse_is_a: HGNC:PPP1R14A -inverse_is_a: HGNC:PPP1R14B -inverse_is_a: HGNC:PPP1R14C -inverse_is_a: HGNC:PPP1R14D -inverse_is_a: HGNC:PPP1R15A -inverse_is_a: HGNC:PPP1R15B -inverse_is_a: HGNC:PPP1R16A -inverse_is_a: HGNC:PPP1R16B -inverse_is_a: HGNC:PPP1R1A -inverse_is_a: HGNC:PPP1R1B -inverse_is_a: HGNC:PPP1R1C -inverse_is_a: HGNC:PPP1R2 -inverse_is_a: HGNC:PPP1R3A -inverse_is_a: HGNC:PPP1R3B -inverse_is_a: HGNC:PPP1R3C -inverse_is_a: HGNC:PPP1R3D -inverse_is_a: HGNC:PPP1R3F -inverse_is_a: HGNC:PPP1R7 -inverse_is_a: HGNC:PPP1R8 -inverse_is_a: HGNC:PPP1R9A -inverse_is_a: HGNC:PPP1R9B - -[Term] -id: FPLX:PPP2 +relationship: part_of FPLX:000376 ! PPP1 +relationship: inverse_is_a HGNC:9284 ! PPP1R10 +relationship: inverse_is_a HGNC:9285 ! PPP1R11 +relationship: inverse_is_a HGNC:7618 ! PPP1R12A +relationship: inverse_is_a HGNC:7619 ! PPP1R12B +relationship: inverse_is_a HGNC:14947 ! PPP1R12C +relationship: inverse_is_a HGNC:14950 ! PPP1R13B +relationship: inverse_is_a HGNC:14871 ! PPP1R14A +relationship: inverse_is_a HGNC:9057 ! PPP1R14B +relationship: inverse_is_a HGNC:14952 ! PPP1R14C +relationship: inverse_is_a HGNC:14953 ! PPP1R14D +relationship: inverse_is_a HGNC:14375 ! PPP1R15A +relationship: inverse_is_a HGNC:14951 ! PPP1R15B +relationship: inverse_is_a HGNC:14941 ! PPP1R16A +relationship: inverse_is_a HGNC:15850 ! PPP1R16B +relationship: inverse_is_a HGNC:9286 ! PPP1R1A +relationship: inverse_is_a HGNC:9287 ! PPP1R1B +relationship: inverse_is_a HGNC:14940 ! PPP1R1C +relationship: inverse_is_a HGNC:9288 ! PPP1R2 +relationship: inverse_is_a HGNC:9291 ! PPP1R3A +relationship: inverse_is_a HGNC:14942 ! PPP1R3B +relationship: inverse_is_a HGNC:9293 ! PPP1R3C +relationship: inverse_is_a HGNC:9294 ! PPP1R3D +relationship: inverse_is_a HGNC:14944 ! PPP1R3F +relationship: inverse_is_a HGNC:9295 ! PPP1R7 +relationship: inverse_is_a HGNC:9296 ! PPP1R8 +relationship: inverse_is_a HGNC:14946 ! PPP1R9A +relationship: inverse_is_a HGNC:9298 ! PPP1R9B + +[Term] +id: FPLX:000379 name: PPP2 synonym: "PP2 phosphatases" EXACT [] synonym: "PP2" EXACT [] @@ -6389,57 +6409,57 @@ synonym: "protein phosphatase 2" EXACT [] xref: MEDSCAN:urn:agi-complex:prophash-f2e03d3bf1f747adab17ce77b9b5e5b3 xref: MEDSCAN:urn:agi-complex:protein%20phosphatase%20type%202A%20complex xref: RE:R-HSA-196206 -is_a: FPLX:root -has_part: FPLX:PPP2C -has_part: FPLX:PPP2R_A -has_part: FPLX:PPP2R_B +is_a: FPLX:000000 ! famplex +relationship: has_part FPLX:000380 ! PPP2C +relationship: has_part FPLX:000381 ! PPP2R_A +relationship: has_part FPLX:000382 ! PPP2R_B [Term] -id: FPLX:PPP2C +id: FPLX:000380 name: PPP2C synonym: "PP2A catalytic C subunit" EXACT [] synonym: "PP2A-C" EXACT [] synonym: "PP2Ac" EXACT [] xref: BEL:"PPP2C Family" -part_of: FPLX:PPP2 -inverse_is_a: HGNC:PPM1J -inverse_is_a: HGNC:PPP2CA -inverse_is_a: HGNC:PPP2CB +relationship: part_of FPLX:000379 ! PPP2 +relationship: inverse_is_a HGNC:20785 ! PPM1J +relationship: inverse_is_a HGNC:9299 ! PPP2CA +relationship: inverse_is_a HGNC:9300 ! PPP2CB [Term] -id: FPLX:PPP2R_A +id: FPLX:000381 name: PPP2R-A synonym: "PP2A regulatory subunit A" EXACT [] synonym: "regulatory A subunit of PP2A" EXACT [] xref: BEL:"PPP2R Subunit A Family" xref: RE:R-HSA-165990 xref: RE:R-HSA-165997 -part_of: FPLX:PPP2 -inverse_is_a: HGNC:PPP2R1A -inverse_is_a: HGNC:PPP2R1B +relationship: part_of FPLX:000379 ! PPP2 +relationship: inverse_is_a HGNC:9302 ! PPP2R1A +relationship: inverse_is_a HGNC:9303 ! PPP2R1B [Term] -id: FPLX:PPP2R_B +id: FPLX:000382 name: PPP2R-B synonym: "PP2A regulatory subunit B" EXACT [] synonym: "regulatory B subunit of PP2A" EXACT [] xref: BEL:"PPP2R Subunit B Family" -part_of: FPLX:PPP2 -inverse_is_a: HGNC:PPP2R2A -inverse_is_a: HGNC:PPP2R2B -inverse_is_a: HGNC:PPP2R2C -inverse_is_a: HGNC:PPP2R2D -inverse_is_a: HGNC:PPP2R3A -inverse_is_a: HGNC:PPP2R3B -inverse_is_a: HGNC:PTPA -inverse_is_a: HGNC:PPP2R5A -inverse_is_a: HGNC:PPP2R5B -inverse_is_a: HGNC:PPP2R5C -inverse_is_a: HGNC:PPP2R5D -inverse_is_a: HGNC:PPP2R5E - -[Term] -id: FPLX:PPP3 +relationship: part_of FPLX:000379 ! PPP2 +relationship: inverse_is_a HGNC:9304 ! PPP2R2A +relationship: inverse_is_a HGNC:9305 ! PPP2R2B +relationship: inverse_is_a HGNC:9306 ! PPP2R2C +relationship: inverse_is_a HGNC:23732 ! PPP2R2D +relationship: inverse_is_a HGNC:9307 ! PPP2R3A +relationship: inverse_is_a HGNC:13417 ! PPP2R3B +relationship: inverse_is_a HGNC:9308 ! PTPA +relationship: inverse_is_a HGNC:9309 ! PPP2R5A +relationship: inverse_is_a HGNC:9310 ! PPP2R5B +relationship: inverse_is_a HGNC:9311 ! PPP2R5C +relationship: inverse_is_a HGNC:9312 ! PPP2R5D +relationship: inverse_is_a HGNC:9313 ! PPP2R5E + +[Term] +id: FPLX:000383 name: PPP3 synonym: "calcineurin" EXACT [] synonym: "CaN" EXACT [] @@ -6448,12 +6468,12 @@ synonym: "protein phosphatase 2B" EXACT [] xref: BEL:"Calcineurin Complex" xref: BEL:"PPP3 Family" xref: MEDSCAN:urn:agi-complex:protein%20phosphatase%203 -is_a: FPLX:root -has_part: FPLX:PPP3C -has_part: FPLX:PPP3R +is_a: FPLX:000000 ! famplex +relationship: has_part FPLX:000384 ! PPP3C +relationship: has_part FPLX:000385 ! PPP3R [Term] -id: FPLX:PPP3C +id: FPLX:000384 name: PPP3C synonym: "Calcineurin catalytic subunit" EXACT [] synonym: "catalytic subunit of calcineurin" EXACT [] @@ -6462,24 +6482,24 @@ xref: BEL:"PPP3C Family" xref: RE:R-HSA-201779 xref: RE:R-HSA-201798 xref: SIGNOR:SIGNOR-PF18 -part_of: FPLX:PPP3 -inverse_is_a: HGNC:PPP3CA -inverse_is_a: HGNC:PPP3CB -inverse_is_a: HGNC:PPP3CC +relationship: part_of FPLX:000383 ! PPP3 +relationship: inverse_is_a HGNC:9314 ! PPP3CA +relationship: inverse_is_a HGNC:9315 ! PPP3CB +relationship: inverse_is_a HGNC:9316 ! PPP3CC [Term] -id: FPLX:PPP3R +id: FPLX:000385 name: PPP3R synonym: "Calcineurin regulatory subunit" EXACT [] synonym: "regulatory subunit of calcineurin" EXACT [] xref: BEL:"PPP3R Family" xref: NEXTPROT-FAMILY:00421 -part_of: FPLX:PPP3 -inverse_is_a: HGNC:PPP3R1 -inverse_is_a: HGNC:PPP3R2 +relationship: part_of FPLX:000383 ! PPP3 +relationship: inverse_is_a HGNC:9317 ! PPP3R1 +relationship: inverse_is_a HGNC:9318 ! PPP3R2 [Term] -id: FPLX:PRC1_complex +id: FPLX:000386 name: PRC1-complex synonym: "polycomb Repressive Complex (PRC) 1" EXACT [] synonym: "Polycomb Repressive Complex 1" EXACT [] @@ -6493,24 +6513,24 @@ xref: BEL:"PRC1 Maintenance Complex" xref: GO:0035102 xref: MEDSCAN:urn:agi-complex:prophash-aba0c4130764ae7a26054736114e65cd xref: NCIT:C19866 -is_a: FPLX:root -has_part: HGNC:BMI1 -has_part: HGNC:CBX2 -has_part: HGNC:CBX4 -has_part: HGNC:CBX8 -has_part: HGNC:PCGF2 -has_part: HGNC:PHC1 -has_part: HGNC:PHC2 -has_part: HGNC:PHC3 -has_part: HGNC:PHF1 -has_part: HGNC:RING1 -has_part: HGNC:RNF2 -has_part: HGNC:SCMH1 -has_part: HGNC:YY1 -has_part: HGNC:ZNF134 - -[Term] -id: FPLX:PRC2_complex +is_a: FPLX:000000 ! famplex +relationship: has_part HGNC:1066 ! BMI1 +relationship: has_part HGNC:1552 ! CBX2 +relationship: has_part HGNC:1554 ! CBX4 +relationship: has_part HGNC:15962 ! CBX8 +relationship: has_part HGNC:12929 ! PCGF2 +relationship: has_part HGNC:3182 ! PHC1 +relationship: has_part HGNC:3183 ! PHC2 +relationship: has_part HGNC:15682 ! PHC3 +relationship: has_part HGNC:8919 ! PHF1 +relationship: has_part HGNC:10018 ! RING1 +relationship: has_part HGNC:10061 ! RNF2 +relationship: has_part HGNC:19003 ! SCMH1 +relationship: has_part HGNC:12856 ! YY1 +relationship: has_part HGNC:12918 ! ZNF134 + +[Term] +id: FPLX:000387 name: PRC2-complex synonym: "Polycomb Repressive Complex 2" EXACT [] synonym: "Polycomb repressive complex 2" EXACT [] @@ -6522,14 +6542,14 @@ synonym: "PRC2" EXACT [] xref: BEL:"PRC2 Initiation Complex" xref: GO:0035098 xref: MEDSCAN:urn:agi-complex:prophash-2b612daa76feb2db86ff39e70449df6b -is_a: FPLX:root -has_part: HGNC:EED -has_part: HGNC:EZH1 -has_part: HGNC:EZH2 -has_part: HGNC:SUZ12 +is_a: FPLX:000000 ! famplex +relationship: has_part HGNC:3188 ! EED +relationship: has_part HGNC:3526 ! EZH1 +relationship: has_part HGNC:3527 ! EZH2 +relationship: has_part HGNC:17101 ! SUZ12 [Term] -id: FPLX:PRDX +id: FPLX:000388 name: PRDX synonym: "Peroxiredoxin" EXACT [] synonym: "peroxiredoxin" EXACT [] @@ -6537,16 +6557,16 @@ synonym: "Peroxiredoxins" EXACT [] synonym: "peroxiredoxins" EXACT [] xref: BEL:"PRDX Family" xref: ECCODE:1.11.1.15 -is_a: FPLX:root -inverse_is_a: HGNC:PRDX1 -inverse_is_a: HGNC:PRDX2 -inverse_is_a: HGNC:PRDX3 -inverse_is_a: HGNC:PRDX4 -inverse_is_a: HGNC:PRDX5 -inverse_is_a: HGNC:PRDX6 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:9352 ! PRDX1 +relationship: inverse_is_a HGNC:9353 ! PRDX2 +relationship: inverse_is_a HGNC:9354 ! PRDX3 +relationship: inverse_is_a HGNC:17169 ! PRDX4 +relationship: inverse_is_a HGNC:9355 ! PRDX5 +relationship: inverse_is_a HGNC:16753 ! PRDX6 [Term] -id: FPLX:PRKAC +id: FPLX:000389 name: PRKAC synonym: "PKA catalytic subunit" EXACT [] synonym: "PKA catalytic subunits" EXACT [] @@ -6556,13 +6576,13 @@ synonym: "Protein kinase A catalytic subunits" EXACT [] synonym: "protein kinase A catalytic subunits" EXACT [] xref: BEL:"PRKA Family" xref: SIGNOR:SIGNOR-PF17 -part_of: FPLX:PKA -inverse_is_a: HGNC:PRKACA -inverse_is_a: HGNC:PRKACB -inverse_is_a: HGNC:PRKACG +relationship: part_of FPLX:000363 ! PKA +relationship: inverse_is_a HGNC:9380 ! PRKACA +relationship: inverse_is_a HGNC:9381 ! PRKACB +relationship: inverse_is_a HGNC:9382 ! PRKACG [Term] -id: FPLX:PRKAR +id: FPLX:000390 name: PRKAR synonym: "PKA regulatory subunit" EXACT [] synonym: "PKA regulatory subunits" EXACT [] @@ -6577,14 +6597,14 @@ xref: RE:R-HSA-111921 xref: RE:R-HSA-111923 xref: RE:R-HSA-5610566 xref: RE:R-HSA-5610568 -part_of: FPLX:PKA -inverse_is_a: HGNC:PRKAR1A -inverse_is_a: HGNC:PRKAR1B -inverse_is_a: HGNC:PRKAR2A -inverse_is_a: HGNC:PRKAR2B +relationship: part_of FPLX:000363 ! PKA +relationship: inverse_is_a HGNC:9388 ! PRKAR1A +relationship: inverse_is_a HGNC:9390 ! PRKAR1B +relationship: inverse_is_a HGNC:9391 ! PRKAR2A +relationship: inverse_is_a HGNC:9392 ! PRKAR2B [Term] -id: FPLX:PRKG +id: FPLX:000391 name: PRKG synonym: "PKG" EXACT [] synonym: "protein kinase G" EXACT [] @@ -6595,12 +6615,12 @@ xref: IP:IPR035014 xref: RE:R-HSA-418379 xref: RE:R-HSA-4551456 xref: RE:R-HSA-4551462 -is_a: FPLX:root -inverse_is_a: HGNC:PRKG1 -inverse_is_a: HGNC:PRKG2 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:9414 ! PRKG1 +relationship: inverse_is_a HGNC:9416 ! PRKG2 [Term] -id: FPLX:Propionyl_CoA_carboxylase +id: FPLX:000392 name: Propionyl-CoA-carboxylase synonym: "Propionyl-CoA carboxylase" EXACT [] synonym: "propionyl-CoA carboxylase" EXACT [] @@ -6612,19 +6632,19 @@ xref: RE:R-HSA-3323122 xref: RE:R-HSA-3323155 xref: RE:R-HSA-71025 xref: RE:R-HSA-71026 -is_a: FPLX:root -has_part: HGNC:PCCA -has_part: HGNC:PCCB +is_a: FPLX:000000 ! famplex +relationship: has_part HGNC:8653 ! PCCA +relationship: has_part HGNC:8654 ! PCCB [Term] -id: FPLX:Protease +id: FPLX:000393 name: Protease synonym: "protease" EXACT [] xref: NCIT:C16965 -is_a: FPLX:root +is_a: FPLX:000000 ! famplex [Term] -id: FPLX:Proteasome +id: FPLX:000394 name: Proteasome synonym: "proteasome endopeptidase" EXACT [] synonym: "proteasome" EXACT [] @@ -6632,78 +6652,78 @@ xref: BEL:"Proteasome Complex" xref: ECCODE:3.4.25.1 xref: GO:0000502 xref: MESH:D046988 -is_a: FPLX:root -has_part: HGNC:PSMA1 -has_part: HGNC:PSMA2 -has_part: HGNC:PSMA3 -has_part: HGNC:PSMA4 -has_part: HGNC:PSMA5 -has_part: HGNC:PSMA6 -has_part: HGNC:PSMA7 -has_part: HGNC:PSMA8 -has_part: HGNC:PSMB1 -has_part: HGNC:PSMB10 -has_part: HGNC:PSMB2 -has_part: HGNC:PSMB3 -has_part: HGNC:PSMB4 -has_part: HGNC:PSMB5 -has_part: HGNC:PSMB6 -has_part: HGNC:PSMB7 -has_part: HGNC:PSMB8 -has_part: HGNC:PSMB9 -has_part: HGNC:PSMC1 -has_part: HGNC:PSMC2 -has_part: HGNC:PSMC3 -has_part: HGNC:PSMC4 -has_part: HGNC:PSMC5 -has_part: HGNC:PSMC6 -has_part: HGNC:PSMD1 -has_part: HGNC:PSMD10 -has_part: HGNC:PSMD11 -has_part: HGNC:PSMD12 -has_part: HGNC:PSMD13 -has_part: HGNC:PSMD14 -has_part: HGNC:PSMD2 -has_part: HGNC:PSMD3 -has_part: HGNC:PSMD4 -has_part: HGNC:PSMD5 -has_part: HGNC:PSMD6 -has_part: HGNC:PSMD7 -has_part: HGNC:PSMD8 -has_part: HGNC:PSMD9 -has_part: HGNC:PSME1 -has_part: HGNC:PSME2 -has_part: HGNC:PSME3 -has_part: HGNC:PSMF1 -has_part: HGNC:SEM1 -has_part: HGNC:USP5 - -[Term] -id: FPLX:PTGER +is_a: FPLX:000000 ! famplex +relationship: has_part HGNC:9530 ! PSMA1 +relationship: has_part HGNC:9531 ! PSMA2 +relationship: has_part HGNC:9532 ! PSMA3 +relationship: has_part HGNC:9533 ! PSMA4 +relationship: has_part HGNC:9534 ! PSMA5 +relationship: has_part HGNC:9535 ! PSMA6 +relationship: has_part HGNC:9536 ! PSMA7 +relationship: has_part HGNC:22985 ! PSMA8 +relationship: has_part HGNC:9537 ! PSMB1 +relationship: has_part HGNC:9538 ! PSMB10 +relationship: has_part HGNC:9539 ! PSMB2 +relationship: has_part HGNC:9540 ! PSMB3 +relationship: has_part HGNC:9541 ! PSMB4 +relationship: has_part HGNC:9542 ! PSMB5 +relationship: has_part HGNC:9543 ! PSMB6 +relationship: has_part HGNC:9544 ! PSMB7 +relationship: has_part HGNC:9545 ! PSMB8 +relationship: has_part HGNC:9546 ! PSMB9 +relationship: has_part HGNC:9547 ! PSMC1 +relationship: has_part HGNC:9548 ! PSMC2 +relationship: has_part HGNC:9549 ! PSMC3 +relationship: has_part HGNC:9551 ! PSMC4 +relationship: has_part HGNC:9552 ! PSMC5 +relationship: has_part HGNC:9553 ! PSMC6 +relationship: has_part HGNC:9554 ! PSMD1 +relationship: has_part HGNC:9555 ! PSMD10 +relationship: has_part HGNC:9556 ! PSMD11 +relationship: has_part HGNC:9557 ! PSMD12 +relationship: has_part HGNC:9558 ! PSMD13 +relationship: has_part HGNC:16889 ! PSMD14 +relationship: has_part HGNC:9559 ! PSMD2 +relationship: has_part HGNC:9560 ! PSMD3 +relationship: has_part HGNC:9561 ! PSMD4 +relationship: has_part HGNC:9563 ! PSMD5 +relationship: has_part HGNC:9564 ! PSMD6 +relationship: has_part HGNC:9565 ! PSMD7 +relationship: has_part HGNC:9566 ! PSMD8 +relationship: has_part HGNC:9567 ! PSMD9 +relationship: has_part HGNC:9568 ! PSME1 +relationship: has_part HGNC:9569 ! PSME2 +relationship: has_part HGNC:9570 ! PSME3 +relationship: has_part HGNC:9571 ! PSMF1 +relationship: has_part HGNC:10845 ! SEM1 +relationship: has_part HGNC:12628 ! USP5 + +[Term] +id: FPLX:000395 name: PTGER synonym: "prostaglandin E receptor" EXACT [] xref: BEL:"PTGER Family" -is_a: FPLX:root -inverse_is_a: HGNC:PTGER1 -inverse_is_a: HGNC:PTGER2 -inverse_is_a: HGNC:PTGER3 -inverse_is_a: HGNC:PTGER4 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:9593 ! PTGER1 +relationship: inverse_is_a HGNC:9594 ! PTGER2 +relationship: inverse_is_a HGNC:9595 ! PTGER3 +relationship: inverse_is_a HGNC:9596 ! PTGER4 [Term] -id: FPLX:PYG +id: FPLX:000396 name: PYG synonym: "Glycogen phosphorylase" EXACT [] synonym: "Glycogen phosphorylases" EXACT [] synonym: "glycogen phosphorylase" EXACT [] synonym: "glycogen phosphorylases" EXACT [] synonym: "PYG" EXACT [] -is_a: FPLX:Glycosyltransferase -inverse_is_a: HGNC:PYGB -inverse_is_a: HGNC:PYGL -inverse_is_a: HGNC:PYGM +is_a: FPLX:000198 ! Glycosyltransferase +relationship: inverse_is_a HGNC:9723 ! PYGB +relationship: inverse_is_a HGNC:9725 ! PYGL +relationship: inverse_is_a HGNC:9726 ! PYGM [Term] -id: FPLX:RAB +id: FPLX:000397 name: RAB synonym: "Rab GTPase" EXACT [] synonym: "Rab GTPases" EXACT [] @@ -6716,90 +6736,90 @@ synonym: "Rabs" EXACT [] xref: BEL:"RAB Family" xref: MEDSCAN:urn:agi-protfc:rab xref: NEXTPROT-FAMILY:03661 -is_a: FPLX:root -inverse_is_a: HGNC:RAB10 -inverse_is_a: HGNC:RAB11A -inverse_is_a: HGNC:RAB11B -inverse_is_a: HGNC:RAB12 -inverse_is_a: HGNC:RAB13 -inverse_is_a: HGNC:RAB14 -inverse_is_a: HGNC:RAB15 -inverse_is_a: HGNC:RAB17 -inverse_is_a: HGNC:RAB18 -inverse_is_a: HGNC:RAB19 -inverse_is_a: HGNC:RAB1A -inverse_is_a: HGNC:RAB1B -inverse_is_a: HGNC:RAB1C -inverse_is_a: HGNC:RAB20 -inverse_is_a: HGNC:RAB21 -inverse_is_a: HGNC:RAB22A -inverse_is_a: HGNC:RAB23 -inverse_is_a: HGNC:RAB24 -inverse_is_a: HGNC:RAB25 -inverse_is_a: HGNC:RAB26 -inverse_is_a: HGNC:RAB27A -inverse_is_a: HGNC:RAB27B -inverse_is_a: HGNC:RAB28 -inverse_is_a: HGNC:RAB2A -inverse_is_a: HGNC:RAB2B -inverse_is_a: HGNC:RAB30 -inverse_is_a: HGNC:RAB31 -inverse_is_a: HGNC:RAB32 -inverse_is_a: HGNC:RAB33A -inverse_is_a: HGNC:RAB33B -inverse_is_a: HGNC:RAB34 -inverse_is_a: HGNC:RAB35 -inverse_is_a: HGNC:RAB36 -inverse_is_a: HGNC:RAB37 -inverse_is_a: HGNC:RAB38 -inverse_is_a: HGNC:RAB39A -inverse_is_a: HGNC:RAB39B -inverse_is_a: HGNC:RAB3A -inverse_is_a: HGNC:RAB3B -inverse_is_a: HGNC:RAB3C -inverse_is_a: HGNC:RAB3D -inverse_is_a: HGNC:RAB40A -inverse_is_a: HGNC:RAB40AL -inverse_is_a: HGNC:RAB40B -inverse_is_a: HGNC:RAB40C -inverse_is_a: HGNC:RAB41 -inverse_is_a: HGNC:RAB42 -inverse_is_a: HGNC:RAB43 -inverse_is_a: HGNC:RAB44 -inverse_is_a: HGNC:RAB4A -inverse_is_a: HGNC:RAB4B -inverse_is_a: HGNC:RAB5A -inverse_is_a: HGNC:RAB5B -inverse_is_a: HGNC:RAB5C -inverse_is_a: HGNC:RAB6A -inverse_is_a: HGNC:RAB6B -inverse_is_a: HGNC:RAB6C -inverse_is_a: HGNC:RAB7A -inverse_is_a: HGNC:RAB7B -inverse_is_a: HGNC:RAB29 -inverse_is_a: HGNC:RAB8A -inverse_is_a: HGNC:RAB8B -inverse_is_a: HGNC:RAB9A -inverse_is_a: HGNC:RAB9B -inverse_is_a: HGNC:RABL2A -inverse_is_a: HGNC:RABL2B -inverse_is_a: HGNC:RABL3 -inverse_is_a: HGNC:IFT22 - -[Term] -id: FPLX:RAC +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:9759 ! RAB10 +relationship: inverse_is_a HGNC:9760 ! RAB11A +relationship: inverse_is_a HGNC:9761 ! RAB11B +relationship: inverse_is_a HGNC:31332 ! RAB12 +relationship: inverse_is_a HGNC:9762 ! RAB13 +relationship: inverse_is_a HGNC:16524 ! RAB14 +relationship: inverse_is_a HGNC:20150 ! RAB15 +relationship: inverse_is_a HGNC:16523 ! RAB17 +relationship: inverse_is_a HGNC:14244 ! RAB18 +relationship: inverse_is_a HGNC:19982 ! RAB19 +relationship: inverse_is_a HGNC:9758 ! RAB1A +relationship: inverse_is_a HGNC:18370 ! RAB1B +relationship: inverse_is_a HGNC:23683 ! RAB1C +relationship: inverse_is_a HGNC:18260 ! RAB20 +relationship: inverse_is_a HGNC:18263 ! RAB21 +relationship: inverse_is_a HGNC:9764 ! RAB22A +relationship: inverse_is_a HGNC:14263 ! RAB23 +relationship: inverse_is_a HGNC:9765 ! RAB24 +relationship: inverse_is_a HGNC:18238 ! RAB25 +relationship: inverse_is_a HGNC:14259 ! RAB26 +relationship: inverse_is_a HGNC:9766 ! RAB27A +relationship: inverse_is_a HGNC:9767 ! RAB27B +relationship: inverse_is_a HGNC:9768 ! RAB28 +relationship: inverse_is_a HGNC:9763 ! RAB2A +relationship: inverse_is_a HGNC:20246 ! RAB2B +relationship: inverse_is_a HGNC:9770 ! RAB30 +relationship: inverse_is_a HGNC:9771 ! RAB31 +relationship: inverse_is_a HGNC:9772 ! RAB32 +relationship: inverse_is_a HGNC:9773 ! RAB33A +relationship: inverse_is_a HGNC:16075 ! RAB33B +relationship: inverse_is_a HGNC:16519 ! RAB34 +relationship: inverse_is_a HGNC:9774 ! RAB35 +relationship: inverse_is_a HGNC:9775 ! RAB36 +relationship: inverse_is_a HGNC:30268 ! RAB37 +relationship: inverse_is_a HGNC:9776 ! RAB38 +relationship: inverse_is_a HGNC:16521 ! RAB39A +relationship: inverse_is_a HGNC:16499 ! RAB39B +relationship: inverse_is_a HGNC:9777 ! RAB3A +relationship: inverse_is_a HGNC:9778 ! RAB3B +relationship: inverse_is_a HGNC:30269 ! RAB3C +relationship: inverse_is_a HGNC:9779 ! RAB3D +relationship: inverse_is_a HGNC:18283 ! RAB40A +relationship: inverse_is_a HGNC:25410 ! RAB40AL +relationship: inverse_is_a HGNC:18284 ! RAB40B +relationship: inverse_is_a HGNC:18285 ! RAB40C +relationship: inverse_is_a HGNC:18293 ! RAB41 +relationship: inverse_is_a HGNC:28702 ! RAB42 +relationship: inverse_is_a HGNC:19983 ! RAB43 +relationship: inverse_is_a HGNC:21068 ! RAB44 +relationship: inverse_is_a HGNC:9781 ! RAB4A +relationship: inverse_is_a HGNC:9782 ! RAB4B +relationship: inverse_is_a HGNC:9783 ! RAB5A +relationship: inverse_is_a HGNC:9784 ! RAB5B +relationship: inverse_is_a HGNC:9785 ! RAB5C +relationship: inverse_is_a HGNC:9786 ! RAB6A +relationship: inverse_is_a HGNC:14902 ! RAB6B +relationship: inverse_is_a HGNC:16525 ! RAB6C +relationship: inverse_is_a HGNC:9788 ! RAB7A +relationship: inverse_is_a HGNC:30513 ! RAB7B +relationship: inverse_is_a HGNC:9789 ! RAB29 +relationship: inverse_is_a HGNC:7007 ! RAB8A +relationship: inverse_is_a HGNC:30273 ! RAB8B +relationship: inverse_is_a HGNC:9792 ! RAB9A +relationship: inverse_is_a HGNC:14090 ! RAB9B +relationship: inverse_is_a HGNC:9799 ! RABL2A +relationship: inverse_is_a HGNC:9800 ! RABL2B +relationship: inverse_is_a HGNC:18072 ! RABL3 +relationship: inverse_is_a HGNC:21895 ! IFT22 + +[Term] +id: FPLX:000398 name: RAC synonym: "RAC" EXACT [] xref: BEL:"RAC Family" xref: NEXTPROT-FAMILY:03066 -is_a: FPLX:root -inverse_is_a: HGNC:RAC1 -inverse_is_a: HGNC:RAC2 -inverse_is_a: HGNC:RAC3 -inverse_is_a: HGNC:RHOG +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:9801 ! RAC1 +relationship: inverse_is_a HGNC:9802 ! RAC2 +relationship: inverse_is_a HGNC:9803 ! RAC3 +relationship: inverse_is_a HGNC:672 ! RHOG [Term] -id: FPLX:RAF +id: FPLX:000399 name: RAF synonym: "RAF" EXACT [] synonym: "Raf" EXACT [] @@ -6809,13 +6829,13 @@ xref: RE:R-HSA-5672708 xref: RE:R-HSA-5672726 xref: RE:R-HSA-5674134 xref: RE:R-HSA-5674136 -is_a: FPLX:MAP3K -inverse_is_a: HGNC:ARAF -inverse_is_a: HGNC:BRAF -inverse_is_a: HGNC:RAF1 +is_a: FPLX:000282 ! MAP3K +relationship: inverse_is_a HGNC:646 ! ARAF +relationship: inverse_is_a HGNC:1097 ! BRAF +relationship: inverse_is_a HGNC:9829 ! RAF1 [Term] -id: FPLX:RAL +id: FPLX:000400 name: RAL synonym: "RAL family" EXACT [] synonym: "Ral family" EXACT [] @@ -6827,43 +6847,43 @@ synonym: "RAL" EXACT [] xref: IP:IPR028412 xref: RE:R-HSA-170994 xref: RE:R-HSA-170998 -is_a: FPLX:root -inverse_is_a: HGNC:RALA -inverse_is_a: HGNC:RALB +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:9839 ! RALA +relationship: inverse_is_a HGNC:9840 ! RALB [Term] -id: FPLX:RAP1 +id: FPLX:000401 name: RAP1 synonym: "Rap1" EXACT [] xref: NEXTPROT-FAMILY:04773 -is_a: FPLX:root -inverse_is_a: HGNC:RAP1A -inverse_is_a: HGNC:RAP1B +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:9855 ! RAP1A +relationship: inverse_is_a HGNC:9857 ! RAP1B [Term] -id: FPLX:RAPGEF +id: FPLX:000402 name: RAPGEF synonym: "Rap guanine nucleotide exchange factor" EXACT [] synonym: "Rap guanine nucleotide exchange factors" EXACT [] synonym: "RapGEFs" EXACT [] -is_a: FPLX:root -inverse_is_a: HGNC:RAPGEF1 -inverse_is_a: HGNC:RAPGEF2 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:4568 ! RAPGEF1 +relationship: inverse_is_a HGNC:16854 ! RAPGEF2 [Term] -id: FPLX:RAR +id: FPLX:000403 name: RAR synonym: "RAR" EXACT [] synonym: "retinoic acid receptors" EXACT [] xref: BEL:"RAR Family" xref: NCIT:C17532 -is_a: FPLX:root -inverse_is_a: HGNC:RARA -inverse_is_a: HGNC:RARB -inverse_is_a: HGNC:RARG +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:9864 ! RARA +relationship: inverse_is_a HGNC:9865 ! RARB +relationship: inverse_is_a HGNC:9866 ! RARG [Term] -id: FPLX:RAS +id: FPLX:000404 name: RAS synonym: "Ras GTPase" EXACT [] synonym: "RAS" EXACT [] @@ -6879,60 +6899,60 @@ xref: RE:R-HSA-109796 xref: RE:R-HSA-167204 xref: RE:R-HSA-6802607 xref: RE:R-HSA-6802608 -is_a: FPLX:root -inverse_is_a: HGNC:KRAS -inverse_is_a: HGNC:HRAS -inverse_is_a: HGNC:NRAS +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:6407 ! KRAS +relationship: inverse_is_a HGNC:5173 ! HRAS +relationship: inverse_is_a HGNC:7989 ! NRAS [Term] -id: FPLX:RASA +id: FPLX:000405 name: RASA synonym: "RASA" EXACT [] -is_a: FPLX:root -inverse_is_a: HGNC:RASA1 -inverse_is_a: HGNC:RASA2 -inverse_is_a: HGNC:RASA3 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:9871 ! RASA1 +relationship: inverse_is_a HGNC:9872 ! RASA2 +relationship: inverse_is_a HGNC:20331 ! RASA3 [Term] -id: FPLX:RASAL +id: FPLX:000406 name: RASAL synonym: "RASAL" EXACT [] -is_a: FPLX:root -inverse_is_a: HGNC:RASAL1 -inverse_is_a: HGNC:RASAL2 -inverse_is_a: HGNC:RASAL3 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:9873 ! RASAL1 +relationship: inverse_is_a HGNC:9874 ! RASAL2 +relationship: inverse_is_a HGNC:26129 ! RASAL3 [Term] -id: FPLX:RasGAP +id: FPLX:000407 name: RasGAP synonym: "RasGAP" EXACT [] synonym: "RasGAPs" EXACT [] xref: XFAM:PF00616 xref: RE:R-HSA-5658216 -is_a: FPLX:root +is_a: FPLX:000000 ! famplex [Term] -id: FPLX:RASGRF +id: FPLX:000408 name: RASGRF synonym: "RASGRF" EXACT [] xref: RE:R-HSA-442734 -is_a: FPLX:root -inverse_is_a: HGNC:RASGRF1 -inverse_is_a: HGNC:RASGRF2 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:9875 ! RASGRF1 +relationship: inverse_is_a HGNC:9876 ! RASGRF2 [Term] -id: FPLX:RASGRP +id: FPLX:000409 name: RASGRP synonym: "RASGRP" EXACT [] xref: RE:R-HSA-2685656 -is_a: FPLX:root -inverse_is_a: HGNC:RASGRP1 -inverse_is_a: HGNC:RASGRP2 -inverse_is_a: HGNC:RASGRP3 -inverse_is_a: HGNC:RASGRP4 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:9878 ! RASGRP1 +relationship: inverse_is_a HGNC:9879 ! RASGRP2 +relationship: inverse_is_a HGNC:14545 ! RASGRP3 +relationship: inverse_is_a HGNC:18958 ! RASGRP4 [Term] -id: FPLX:RASSF +id: FPLX:000410 name: RASSF synonym: "RAS association domain family" EXACT [] synonym: "Ras association domain family" EXACT [] @@ -6940,20 +6960,20 @@ synonym: "RAS-association domain family" EXACT [] synonym: "Ras-association domain family" EXACT [] synonym: "RASSF family" EXACT [] xref: IP:IPR033614 -is_a: FPLX:root -inverse_is_a: HGNC:RASSF1 -inverse_is_a: HGNC:RASSF2 -inverse_is_a: HGNC:RASSF3 -inverse_is_a: HGNC:RASSF4 -inverse_is_a: HGNC:RASSF5 -inverse_is_a: HGNC:RASSF6 -inverse_is_a: HGNC:RASSF7 -inverse_is_a: HGNC:RASSF8 -inverse_is_a: HGNC:RASSF9 -inverse_is_a: HGNC:RASSF10 - -[Term] -id: FPLX:RFC +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:9882 ! RASSF1 +relationship: inverse_is_a HGNC:9883 ! RASSF2 +relationship: inverse_is_a HGNC:14271 ! RASSF3 +relationship: inverse_is_a HGNC:20793 ! RASSF4 +relationship: inverse_is_a HGNC:17609 ! RASSF5 +relationship: inverse_is_a HGNC:20796 ! RASSF6 +relationship: inverse_is_a HGNC:1166 ! RASSF7 +relationship: inverse_is_a HGNC:13232 ! RASSF8 +relationship: inverse_is_a HGNC:15739 ! RASSF9 +relationship: inverse_is_a HGNC:33984 ! RASSF10 + +[Term] +id: FPLX:000411 name: RFC synonym: "DNA replication factor C complex" EXACT [] synonym: "DNA replication factor C" EXACT [] @@ -6965,15 +6985,15 @@ xref: GO:0005663 xref: MEDSCAN:urn:agi-complex:prophash-7629c2cdfdf4908b72f13917a7c1551e xref: RE:R-HSA-174454 xref: RE:R-HSA-68436 -is_a: FPLX:root -has_part: HGNC:RFC1 -has_part: HGNC:RFC2 -has_part: HGNC:RFC3 -has_part: HGNC:RFC4 -has_part: HGNC:RFC5 +is_a: FPLX:000000 ! famplex +relationship: has_part HGNC:9969 ! RFC1 +relationship: has_part HGNC:9970 ! RFC2 +relationship: has_part HGNC:9971 ! RFC3 +relationship: has_part HGNC:9972 ! RFC4 +relationship: has_part HGNC:9973 ! RFC5 [Term] -id: FPLX:RFX +id: FPLX:000412 name: RFX synonym: "regulatory family X" EXACT [] synonym: "RF-X" EXACT [] @@ -6982,30 +7002,30 @@ synonym: "RFX proteins" EXACT [] synonym: "RFX" EXACT [] xref: BEL:"RFX Family" xref: MEDSCAN:urn:agi-aopfc:0000157 -is_a: FPLX:root -inverse_is_a: HGNC:RFX1 -inverse_is_a: HGNC:RFX2 -inverse_is_a: HGNC:RFX3 -inverse_is_a: HGNC:RFX4 -inverse_is_a: HGNC:RFX5 -inverse_is_a: HGNC:RFX6 -inverse_is_a: HGNC:RFX7 -inverse_is_a: HGNC:RFX8 - -[Term] -id: FPLX:RGL +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:9982 ! RFX1 +relationship: inverse_is_a HGNC:9983 ! RFX2 +relationship: inverse_is_a HGNC:9984 ! RFX3 +relationship: inverse_is_a HGNC:9985 ! RFX4 +relationship: inverse_is_a HGNC:9986 ! RFX5 +relationship: inverse_is_a HGNC:21478 ! RFX6 +relationship: inverse_is_a HGNC:25777 ! RFX7 +relationship: inverse_is_a HGNC:37253 ! RFX8 + +[Term] +id: FPLX:000413 name: RGL synonym: "RAL guanine nucleotide dissociation stimulator like" EXACT [] synonym: "Ral guanine nucleotide dissociation stimulator like" EXACT [] synonym: "ral guanine nucleotide dissociation stimulator like" EXACT [] synonym: "RALGDS-like" EXACT [] -is_a: FPLX:root -inverse_is_a: HGNC:RGL1 -inverse_is_a: HGNC:RGL2 -inverse_is_a: HGNC:RGL3 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:30281 ! RGL1 +relationship: inverse_is_a HGNC:9769 ! RGL2 +relationship: inverse_is_a HGNC:30282 ! RGL3 [Term] -id: FPLX:RHO +id: FPLX:000414 name: RHO synonym: "Rho family" EXACT [] synonym: "RHO" EXACT [] @@ -7015,13 +7035,13 @@ xref: NEXTPROT-FAMILY:03668 xref: RE:R-HSA-419160 xref: RE:R-HSA-419161 xref: RE:R-HSA-419164 -is_a: FPLX:root -inverse_is_a: HGNC:RHOA -inverse_is_a: HGNC:RHOB -inverse_is_a: HGNC:RHOC +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:667 ! RHOA +relationship: inverse_is_a HGNC:668 ! RHOB +relationship: inverse_is_a HGNC:669 ! RHOC [Term] -id: FPLX:RhoGDI +id: FPLX:000415 name: RhoGDI synonym: "Rho-GDI" EXACT [] synonym: "RHOGDI" EXACT [] @@ -7030,13 +7050,13 @@ synonym: "rhoGDI" EXACT [] synonym: "RhoGDIs" EXACT [] xref: GO:0005094 xref: IP:IPR000406 -is_a: FPLX:root -inverse_is_a: HGNC:ARHGDIA -inverse_is_a: HGNC:ARHGDIB -inverse_is_a: HGNC:ARHGDIG +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:678 ! ARHGDIA +relationship: inverse_is_a HGNC:679 ! ARHGDIB +relationship: inverse_is_a HGNC:680 ! ARHGDIG [Term] -id: FPLX:RNApo_I +id: FPLX:000416 name: RNApo-I synonym: "Pol I" EXACT [] synonym: "RNA polymerase 1" EXACT [] @@ -7044,14 +7064,14 @@ synonym: "RNA polymerase I" EXACT [] xref: BEL:"RNApo I Complex" xref: GO:0005736 xref: NCIT:C95947 -is_a: FPLX:root -has_part: HGNC:POLR1A -has_part: HGNC:POLR1B -has_part: HGNC:POLR1C -has_part: HGNC:POLR1D +is_a: FPLX:000000 ! famplex +relationship: has_part HGNC:17264 ! POLR1A +relationship: has_part HGNC:20454 ! POLR1B +relationship: has_part HGNC:20194 ! POLR1C +relationship: has_part HGNC:20422 ! POLR1D [Term] -id: FPLX:RNApo_II +id: FPLX:000417 name: RNApo-II synonym: "RNA polymerase II" EXACT [] synonym: "RNAP II" EXACT [] @@ -7059,32 +7079,32 @@ xref: BEL:"RNApo II Complex" xref: GO:0005665 xref: MEDSCAN:urn:agi-complex:prophash-d9fbae788d60df23b6be4a3ead2cbab4 xref: NCIT:C95948 -is_a: FPLX:root -has_part: HGNC:POLR2A -has_part: HGNC:POLR2B -has_part: HGNC:POLR2C -has_part: HGNC:POLR2D -has_part: HGNC:POLR2E -has_part: HGNC:POLR2F -has_part: HGNC:POLR2G -has_part: HGNC:POLR2H -has_part: HGNC:POLR2I -has_part: HGNC:POLR2J -has_part: HGNC:POLR2J2 -has_part: HGNC:POLR2K -has_part: HGNC:POLR2L - -[Term] -id: FPLX:ROBO +is_a: FPLX:000000 ! famplex +relationship: has_part HGNC:9187 ! POLR2A +relationship: has_part HGNC:9188 ! POLR2B +relationship: has_part HGNC:9189 ! POLR2C +relationship: has_part HGNC:9191 ! POLR2D +relationship: has_part HGNC:9192 ! POLR2E +relationship: has_part HGNC:9193 ! POLR2F +relationship: has_part HGNC:9194 ! POLR2G +relationship: has_part HGNC:9195 ! POLR2H +relationship: has_part HGNC:9196 ! POLR2I +relationship: has_part HGNC:9197 ! POLR2J +relationship: has_part HGNC:23208 ! POLR2J2 +relationship: has_part HGNC:9198 ! POLR2K +relationship: has_part HGNC:9199 ! POLR2L + +[Term] +id: FPLX:000418 name: ROBO xref: SIGNOR:SIGNOR-PF14 -is_a: FPLX:root -inverse_is_a: HGNC:ROBO1 -inverse_is_a: HGNC:ROBO2 -inverse_is_a: HGNC:ROBO3 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:10249 ! ROBO1 +relationship: inverse_is_a HGNC:10250 ! ROBO2 +relationship: inverse_is_a HGNC:13433 ! ROBO3 [Term] -id: FPLX:ROCK +id: FPLX:000419 name: ROCK synonym: "ROCK" EXACT [] xref: BEL:"ROCK Family" @@ -7092,12 +7112,12 @@ xref: IP:IPR015008 xref: IP:IPR020684 xref: RE:R-HSA-419057 xref: RE:R-HSA-4687776 -is_a: FPLX:root -inverse_is_a: HGNC:ROCK1 -inverse_is_a: HGNC:ROCK2 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:10251 ! ROCK1 +relationship: inverse_is_a HGNC:10252 ! ROCK2 [Term] -id: FPLX:ROR +id: FPLX:000420 name: ROR synonym: "receptor tyrosine kinase-like orphan receptor" EXACT [] synonym: "receptor tyrosine kinase-like orphan receptors" EXACT [] @@ -7107,39 +7127,39 @@ xref: BEL:"ROR Family" xref: IP:IPR016247 xref: MEDSCAN:urn:agi-aopfc:0000286 xref: NEXTPROT-FAMILY:03130 -is_a: FPLX:root -inverse_is_a: HGNC:ROR1 -inverse_is_a: HGNC:ROR2 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:10256 ! ROR1 +relationship: inverse_is_a HGNC:10257 ! ROR2 [Term] -id: FPLX:RPA +id: FPLX:000421 name: RPA synonym: "Replication protein A" EXACT [] synonym: "replication protein A" EXACT [] synonym: "RPA" EXACT [] xref: RE:R-HSA-68462 -is_a: FPLX:root -has_part: HGNC:RPA1 -has_part: HGNC:RPA2 -has_part: HGNC:RPA3 +is_a: FPLX:000000 ! famplex +relationship: has_part HGNC:10289 ! RPA1 +relationship: has_part HGNC:10290 ! RPA2 +relationship: has_part HGNC:10291 ! RPA3 [Term] -id: FPLX:RSK +id: FPLX:000422 name: RSK synonym: "RSK" EXACT [] -is_a: FPLX:root -inverse_is_a: FPLX:P90RSK -inverse_is_a: FPLX:P70S6K +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a FPLX:000329 ! P90RSK +relationship: inverse_is_a FPLX:000328 ! P70S6K [Term] -id: FPLX:RTK +id: FPLX:000423 name: RTK synonym: "RTKs" EXACT [] xref: NCIT:C17660 -is_a: FPLX:root +is_a: FPLX:000000 ! famplex [Term] -id: FPLX:RXR +id: FPLX:000424 name: RXR synonym: "retinoid X receptors" EXACT [] synonym: "retinoid-X receptor" EXACT [] @@ -7148,50 +7168,50 @@ xref: BEL:"RXR Family" xref: GO:0004886 xref: MEDSCAN:urn:agi-complex:prophash-bd459ca2937257c9e3f2b75abf22f422 xref: NCIT:C17534 -is_a: FPLX:root -inverse_is_a: HGNC:RXRA -inverse_is_a: HGNC:RXRB -inverse_is_a: HGNC:RXRG +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:10477 ! RXRA +relationship: inverse_is_a HGNC:10478 ! RXRB +relationship: inverse_is_a HGNC:10479 ! RXRG [Term] -id: FPLX:S100 +id: FPLX:000425 name: S100 synonym: "S100" EXACT [] -is_a: FPLX:root -inverse_is_a: FPLX:S100A -inverse_is_a: HGNC:S100B -inverse_is_a: HGNC:S100G -inverse_is_a: HGNC:S100P -inverse_is_a: HGNC:S100Z +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a FPLX:000426 ! S100A +relationship: inverse_is_a HGNC:10500 ! S100B +relationship: inverse_is_a HGNC:1436 ! S100G +relationship: inverse_is_a HGNC:10504 ! S100P +relationship: inverse_is_a HGNC:30367 ! S100Z [Term] -id: FPLX:S100A +id: FPLX:000426 name: S100A synonym: "S100A" EXACT [] synonym: "S100a" EXACT [] xref: BEL:"S100A Family" -is_a: FPLX:S100 -inverse_is_a: HGNC:HRNR -inverse_is_a: HGNC:S100A1 -inverse_is_a: HGNC:S100A10 -inverse_is_a: HGNC:S100A11 -inverse_is_a: HGNC:S100A12 -inverse_is_a: HGNC:S100A13 -inverse_is_a: HGNC:S100A14 -inverse_is_a: HGNC:S100A16 -inverse_is_a: HGNC:S100A2 -inverse_is_a: HGNC:S100A3 -inverse_is_a: HGNC:S100A4 -inverse_is_a: HGNC:S100A5 -inverse_is_a: HGNC:S100A6 -inverse_is_a: HGNC:S100A7 -inverse_is_a: HGNC:S100A7A -inverse_is_a: HGNC:S100A8 -inverse_is_a: HGNC:S100A9 -inverse_is_a: HGNC:TCHHL1 - -[Term] -id: FPLX:S1PR +is_a: FPLX:000425 ! S100 +relationship: inverse_is_a HGNC:20846 ! HRNR +relationship: inverse_is_a HGNC:10486 ! S100A1 +relationship: inverse_is_a HGNC:10487 ! S100A10 +relationship: inverse_is_a HGNC:10488 ! S100A11 +relationship: inverse_is_a HGNC:10489 ! S100A12 +relationship: inverse_is_a HGNC:10490 ! S100A13 +relationship: inverse_is_a HGNC:18901 ! S100A14 +relationship: inverse_is_a HGNC:20441 ! S100A16 +relationship: inverse_is_a HGNC:10492 ! S100A2 +relationship: inverse_is_a HGNC:10493 ! S100A3 +relationship: inverse_is_a HGNC:10494 ! S100A4 +relationship: inverse_is_a HGNC:10495 ! S100A5 +relationship: inverse_is_a HGNC:10496 ! S100A6 +relationship: inverse_is_a HGNC:10497 ! S100A7 +relationship: inverse_is_a HGNC:21657 ! S100A7A +relationship: inverse_is_a HGNC:10498 ! S100A8 +relationship: inverse_is_a HGNC:10499 ! S100A9 +relationship: inverse_is_a HGNC:31796 ! TCHHL1 + +[Term] +id: FPLX:000427 name: S1PR synonym: "S1P receptor" EXACT [] synonym: "S1PR" EXACT [] @@ -7202,28 +7222,28 @@ xref: GO:0038036 xref: IP:IPR004061 xref: RE:R-HSA-419346 xref: RE:R-HSA-419401 -is_a: FPLX:root -inverse_is_a: HGNC:S1PR1 -inverse_is_a: HGNC:S1PR2 -inverse_is_a: HGNC:S1PR3 -inverse_is_a: HGNC:S1PR4 -inverse_is_a: HGNC:S1PR5 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:3165 ! S1PR1 +relationship: inverse_is_a HGNC:3169 ! S1PR2 +relationship: inverse_is_a HGNC:3167 ! S1PR3 +relationship: inverse_is_a HGNC:3170 ! S1PR4 +relationship: inverse_is_a HGNC:14299 ! S1PR5 [Term] -id: FPLX:SAA +id: FPLX:000428 name: SAA synonym: "SAA" EXACT [] xref: BEL:"SAA Family" xref: IP:IPR000096 xref: NEXTPROT-FAMILY:03483 xref: XFAM:PF00277 -is_a: FPLX:root -inverse_is_a: HGNC:SAA1 -inverse_is_a: HGNC:SAA2 -inverse_is_a: HGNC:SAA4 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:10513 ! SAA1 +relationship: inverse_is_a HGNC:10514 ! SAA2 +relationship: inverse_is_a HGNC:10516 ! SAA4 [Term] -id: FPLX:SCD +id: FPLX:000429 name: SCD synonym: "stearoyl-CoA 9-desaturase" EXACT [] synonym: "Stearoyl-CoA desaturase" EXACT [] @@ -7232,12 +7252,12 @@ xref: BEL:"SCD Family" xref: ECCODE:1.14.19.1 xref: IP:IPR001522 xref: IP:IPR015876 -is_a: FPLX:root -inverse_is_a: HGNC:SCD -inverse_is_a: HGNC:SCD5 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:10571 ! SCD +relationship: inverse_is_a HGNC:21088 ! SCD5 [Term] -id: FPLX:SERCA +id: FPLX:000430 name: SERCA synonym: "sarcoplasmic/endoplasmic reticulum calcium ATPase" EXACT [] synonym: "SERCA" EXACT [] @@ -7248,36 +7268,36 @@ xref: IP:IPR005782 xref: MEDSCAN:urn:agi-protfc:sarcoplasmic%20reticulum%20calcium%20transporting%20adenosine%20triphosphatase xref: RE:R-HSA-418312 xref: RE:R-HSA-427905 -is_a: FPLX:root -inverse_is_a: HGNC:ATP2A1 -inverse_is_a: HGNC:ATP2A2 -inverse_is_a: HGNC:ATP2A3 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:811 ! ATP2A1 +relationship: inverse_is_a HGNC:812 ! ATP2A2 +relationship: inverse_is_a HGNC:813 ! ATP2A3 [Term] -id: FPLX:SERPINB +id: FPLX:000431 name: SERPINB synonym: "Clade B serpin" EXACT [] synonym: "clade B serpins" EXACT [] synonym: "ov-serpins" EXACT [] xref: BEL:"SERPINB Family" xref: NEXTPROT-FAMILY:03579 -is_a: FPLX:root -inverse_is_a: HGNC:SERPINB1 -inverse_is_a: HGNC:SERPINB2 -inverse_is_a: HGNC:SERPINB3 -inverse_is_a: HGNC:SERPINB4 -inverse_is_a: HGNC:SERPINB5 -inverse_is_a: HGNC:SERPINB6 -inverse_is_a: HGNC:SERPINB7 -inverse_is_a: HGNC:SERPINB8 -inverse_is_a: HGNC:SERPINB9 -inverse_is_a: HGNC:SERPINB10 -inverse_is_a: HGNC:SERPINB11 -inverse_is_a: HGNC:SERPINB12 -inverse_is_a: HGNC:SERPINB13 - -[Term] -id: FPLX:SHC +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:3311 ! SERPINB1 +relationship: inverse_is_a HGNC:8584 ! SERPINB2 +relationship: inverse_is_a HGNC:10569 ! SERPINB3 +relationship: inverse_is_a HGNC:10570 ! SERPINB4 +relationship: inverse_is_a HGNC:8949 ! SERPINB5 +relationship: inverse_is_a HGNC:8950 ! SERPINB6 +relationship: inverse_is_a HGNC:13902 ! SERPINB7 +relationship: inverse_is_a HGNC:8952 ! SERPINB8 +relationship: inverse_is_a HGNC:8955 ! SERPINB9 +relationship: inverse_is_a HGNC:8942 ! SERPINB10 +relationship: inverse_is_a HGNC:14221 ! SERPINB11 +relationship: inverse_is_a HGNC:14220 ! SERPINB12 +relationship: inverse_is_a HGNC:8944 ! SERPINB13 + +[Term] +id: FPLX:000432 name: SHC synonym: "Shc family" EXACT [] synonym: "SHC" EXACT [] @@ -7285,24 +7305,24 @@ synonym: "Shc" EXACT [] xref: IP:IPR006019 xref: MEDSCAN:urn:agi-protfc:shc%20protein xref: RE:R-HSA-167023 -is_a: FPLX:root -inverse_is_a: HGNC:SHC1 -inverse_is_a: HGNC:SHC2 -inverse_is_a: HGNC:SHC3 -inverse_is_a: HGNC:SHC4 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:10840 ! SHC1 +relationship: inverse_is_a HGNC:29869 ! SHC2 +relationship: inverse_is_a HGNC:18181 ! SHC3 +relationship: inverse_is_a HGNC:16743 ! SHC4 [Term] -id: FPLX:SIK +id: FPLX:000433 name: SIK synonym: "SIK" EXACT [] synonym: "salt inducible kinase" EXACT [] -is_a: FPLX:root -inverse_is_a: HGNC:SIK1 -inverse_is_a: HGNC:SIK2 -inverse_is_a: HGNC:SIK3 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:11142 ! SIK1 +relationship: inverse_is_a HGNC:21680 ! SIK2 +relationship: inverse_is_a HGNC:29165 ! SIK3 [Term] -id: FPLX:SLC2A +id: FPLX:000434 name: SLC2A synonym: "glucose transporter" EXACT [] synonym: "glucose transporters" EXACT [] @@ -7311,23 +7331,23 @@ synonym: "SLC2" EXACT [] xref: BEL:"SLC2A Family" xref: GO:0005355 xref: NEXTPROT-FAMILY:02159 -is_a: FPLX:root -inverse_is_a: HGNC:SLC2A1 -inverse_is_a: HGNC:SLC2A2 -inverse_is_a: HGNC:SLC2A3 -inverse_is_a: HGNC:SLC2A4 -inverse_is_a: HGNC:SLC2A5 -inverse_is_a: HGNC:SLC2A6 -inverse_is_a: HGNC:SLC2A7 -inverse_is_a: HGNC:SLC2A8 -inverse_is_a: HGNC:SLC2A9 -inverse_is_a: HGNC:SLC2A10 -inverse_is_a: HGNC:SLC2A11 -inverse_is_a: HGNC:SLC2A12 -inverse_is_a: HGNC:SLC2A14 - -[Term] -id: FPLX:SLRP +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:11005 ! SLC2A1 +relationship: inverse_is_a HGNC:11006 ! SLC2A2 +relationship: inverse_is_a HGNC:11007 ! SLC2A3 +relationship: inverse_is_a HGNC:11009 ! SLC2A4 +relationship: inverse_is_a HGNC:11010 ! SLC2A5 +relationship: inverse_is_a HGNC:11011 ! SLC2A6 +relationship: inverse_is_a HGNC:13445 ! SLC2A7 +relationship: inverse_is_a HGNC:13812 ! SLC2A8 +relationship: inverse_is_a HGNC:13446 ! SLC2A9 +relationship: inverse_is_a HGNC:13444 ! SLC2A10 +relationship: inverse_is_a HGNC:14239 ! SLC2A11 +relationship: inverse_is_a HGNC:18067 ! SLC2A12 +relationship: inverse_is_a HGNC:18301 ! SLC2A14 + +[Term] +id: FPLX:000435 name: SLRP synonym: "SLRP" EXACT [] synonym: "SLRPs" EXACT [] @@ -7341,62 +7361,62 @@ synonym: "small leucine-rich proteoglycan" EXACT [] synonym: "small leucine-rich proteoglycans" EXACT [] xref: NEXTPROT-FAMILY:03672 xref: SIGNOR:SIGNOR-PF31 -is_a: FPLX:root -inverse_is_a: FPLX:SLRP_1 -inverse_is_a: FPLX:SLRP_2 -inverse_is_a: FPLX:SLRP_3 -inverse_is_a: FPLX:SLRP_4 -inverse_is_a: FPLX:SLRP_5 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a FPLX:000436 ! SLRP_1 +relationship: inverse_is_a FPLX:000437 ! SLRP_2 +relationship: inverse_is_a FPLX:000438 ! SLRP_3 +relationship: inverse_is_a FPLX:000439 ! SLRP_4 +relationship: inverse_is_a FPLX:000440 ! SLRP_5 [Term] -id: FPLX:SLRP_1 +id: FPLX:000436 name: SLRP-1 xref: NEXTPROT-FAMILY:03673 -is_a: FPLX:SLRP -inverse_is_a: HGNC:BGN -inverse_is_a: HGNC:DCN -inverse_is_a: HGNC:ASPN -inverse_is_a: HGNC:ECM2 +is_a: FPLX:000435 ! SLRP +relationship: inverse_is_a HGNC:1044 ! BGN +relationship: inverse_is_a HGNC:2705 ! DCN +relationship: inverse_is_a HGNC:14872 ! ASPN +relationship: inverse_is_a HGNC:3154 ! ECM2 [Term] -id: FPLX:SLRP_2 +id: FPLX:000437 name: SLRP-2 xref: NEXTPROT-FAMILY:03674 -is_a: FPLX:SLRP -inverse_is_a: HGNC:FMOD -inverse_is_a: HGNC:LUM -inverse_is_a: HGNC:PRELP -inverse_is_a: HGNC:KERA -inverse_is_a: HGNC:OMD +is_a: FPLX:000435 ! SLRP +relationship: inverse_is_a HGNC:3774 ! FMOD +relationship: inverse_is_a HGNC:6724 ! LUM +relationship: inverse_is_a HGNC:9357 ! PRELP +relationship: inverse_is_a HGNC:6309 ! KERA +relationship: inverse_is_a HGNC:8134 ! OMD [Term] -id: FPLX:SLRP_3 +id: FPLX:000438 name: SLRP-3 xref: NEXTPROT-FAMILY:03675 -is_a: FPLX:SLRP -inverse_is_a: HGNC:EPYC -inverse_is_a: HGNC:OPTC -inverse_is_a: HGNC:OGN +is_a: FPLX:000435 ! SLRP +relationship: inverse_is_a HGNC:3053 ! EPYC +relationship: inverse_is_a HGNC:8158 ! OPTC +relationship: inverse_is_a HGNC:8126 ! OGN [Term] -id: FPLX:SLRP_4 +id: FPLX:000439 name: SLRP-4 xref: NEXTPROT-FAMILY:03676 -is_a: FPLX:SLRP -inverse_is_a: HGNC:CHAD -inverse_is_a: HGNC:NYX -inverse_is_a: HGNC:TSKU +is_a: FPLX:000435 ! SLRP +relationship: inverse_is_a HGNC:1909 ! CHAD +relationship: inverse_is_a HGNC:8082 ! NYX +relationship: inverse_is_a HGNC:28850 ! TSKU [Term] -id: FPLX:SLRP_5 +id: FPLX:000440 name: SLRP-5 xref: NEXTPROT-FAMILY:03677 -is_a: FPLX:SLRP -inverse_is_a: HGNC:PODN -inverse_is_a: HGNC:PODNL1 +is_a: FPLX:000435 ! SLRP +relationship: inverse_is_a HGNC:23174 ! PODN +relationship: inverse_is_a HGNC:26275 ! PODNL1 [Term] -id: FPLX:SMAD +id: FPLX:000441 name: SMAD synonym: "SMAD" EXACT [] synonym: "Smad" EXACT [] @@ -7407,27 +7427,27 @@ xref: IP:IPR013019 xref: IP:IPR013790 xref: MEDSCAN:urn:agi-aopfc:0000159 xref: MEDSCAN:urn:agi-complex:prophash-72ef5fc0ab431a39e0e2915bf55b6e28 -is_a: FPLX:root -inverse_is_a: HGNC:SMAD1 -inverse_is_a: HGNC:SMAD4 -inverse_is_a: HGNC:SMAD5 -inverse_is_a: HGNC:SMAD6 -inverse_is_a: HGNC:SMAD7 -inverse_is_a: HGNC:SMAD9 -inverse_is_a: FPLX:SMAD2_3 -inverse_is_a: FPLX:SMAD1_5_9 - -[Term] -id: FPLX:SMAD1_5_9 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:6767 ! SMAD1 +relationship: inverse_is_a HGNC:6770 ! SMAD4 +relationship: inverse_is_a HGNC:6771 ! SMAD5 +relationship: inverse_is_a HGNC:6772 ! SMAD6 +relationship: inverse_is_a HGNC:6773 ! SMAD7 +relationship: inverse_is_a HGNC:6774 ! SMAD9 +relationship: inverse_is_a FPLX:000443 ! SMAD2_3 +relationship: inverse_is_a FPLX:000442 ! SMAD1_5_9 + +[Term] +id: FPLX:000442 name: SMAD1-5-9 xref: SIGNOR:SIGNOR-PF35 -is_a: FPLX:SMAD -inverse_is_a: HGNC:SMAD1 -inverse_is_a: HGNC:SMAD5 -inverse_is_a: HGNC:SMAD9 +is_a: FPLX:000441 ! SMAD +relationship: inverse_is_a HGNC:6767 ! SMAD1 +relationship: inverse_is_a HGNC:6771 ! SMAD5 +relationship: inverse_is_a HGNC:6774 ! SMAD9 [Term] -id: FPLX:SMAD2_3 +id: FPLX:000443 name: SMAD2-3 synonym: "SMAD 2/3" EXACT [] synonym: "SMAD2/3" EXACT [] @@ -7439,83 +7459,83 @@ xref: RE:R-HSA-177105 xref: RE:R-HSA-2176482 xref: RE:R-HSA-2187329 xref: RE:R-HSA-2187387 -is_a: FPLX:SMAD -inverse_is_a: HGNC:SMAD2 -inverse_is_a: HGNC:SMAD3 +is_a: FPLX:000441 ! SMAD +relationship: inverse_is_a HGNC:6768 ! SMAD2 +relationship: inverse_is_a HGNC:6769 ! SMAD3 [Term] -id: FPLX:SMC1 +id: FPLX:000444 name: SMC1 synonym: "SMC1" EXACT [] synonym: "Smc1" EXACT [] xref: BEL:"SMC1 Family" xref: NEXTPROT-FAMILY:03686 -is_a: FPLX:root -inverse_is_a: HGNC:SMC1A -inverse_is_a: HGNC:SMC1B +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:11111 ! SMC1A +relationship: inverse_is_a HGNC:11112 ! SMC1B [Term] -id: FPLX:SMURF +id: FPLX:000445 name: SMURF xref: SIGNOR:SIGNOR-PF29 -is_a: FPLX:root -inverse_is_a: HGNC:SMURF1 -inverse_is_a: HGNC:SMURF2 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:16807 ! SMURF1 +relationship: inverse_is_a HGNC:16809 ! SMURF2 [Term] -id: FPLX:SNAI +id: FPLX:000446 name: SNAI synonym: "SNAI family" EXACT [] synonym: "SNAI" EXACT [] xref: BEL:"SNAI Family" -is_a: FPLX:root -inverse_is_a: HGNC:SNAI1 -inverse_is_a: HGNC:SNAI2 -inverse_is_a: HGNC:SNAI3 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:11128 ! SNAI1 +relationship: inverse_is_a HGNC:11094 ! SNAI2 +relationship: inverse_is_a HGNC:18411 ! SNAI3 [Term] -id: FPLX:SOD +id: FPLX:000447 name: SOD synonym: "SOD" EXACT [] xref: BEL:"Cu-Zn SOD Family" -is_a: FPLX:root -inverse_is_a: HGNC:SOD1 -inverse_is_a: HGNC:SOD2 -inverse_is_a: HGNC:SOD3 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:11179 ! SOD1 +relationship: inverse_is_a HGNC:11180 ! SOD2 +relationship: inverse_is_a HGNC:11181 ! SOD3 [Term] -id: FPLX:SOS +id: FPLX:000448 name: SOS synonym: "SOS" EXACT [] xref: BEL:"SOS Family" xref: RE:R-HSA-167215 -is_a: FPLX:root -inverse_is_a: HGNC:SOS1 -inverse_is_a: HGNC:SOS2 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:11187 ! SOS1 +relationship: inverse_is_a HGNC:11188 ! SOS2 [Term] -id: FPLX:SPRED +id: FPLX:000449 name: SPRED synonym: "SPRED" EXACT [] xref: IP:IPR023337 xref: RE:R-HSA-5658219 -is_a: FPLX:root -inverse_is_a: HGNC:SPRED1 -inverse_is_a: HGNC:SPRED2 -inverse_is_a: HGNC:SPRED3 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:20249 ! SPRED1 +relationship: inverse_is_a HGNC:17722 ! SPRED2 +relationship: inverse_is_a HGNC:31041 ! SPRED3 [Term] -id: FPLX:SPRY +id: FPLX:000450 name: SPRY synonym: "SPRY" EXACT [] -is_a: FPLX:root -inverse_is_a: HGNC:SPRY1 -inverse_is_a: HGNC:SPRY2 -inverse_is_a: HGNC:SPRY3 -inverse_is_a: HGNC:SPRY4 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:11269 ! SPRY1 +relationship: inverse_is_a HGNC:11270 ! SPRY2 +relationship: inverse_is_a HGNC:11271 ! SPRY3 +relationship: inverse_is_a HGNC:15533 ! SPRY4 [Term] -id: FPLX:SRC +id: FPLX:000451 name: SRC synonym: "SFK" EXACT [] synonym: "Src family kinase" EXACT [] @@ -7527,14 +7547,14 @@ xref: BEL:"SRC Family" xref: MEDSCAN:urn:agi-aopfc:0000509 xref: NEXTPROT-FAMILY:03131 xref: SIGNOR:SIGNOR-PF32 -is_a: FPLX:root -inverse_is_a: HGNC:FGR -inverse_is_a: HGNC:FYN -inverse_is_a: HGNC:SRC -inverse_is_a: HGNC:YES1 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:3697 ! FGR +relationship: inverse_is_a HGNC:4037 ! FYN +relationship: inverse_is_a HGNC:11283 ! SRC +relationship: inverse_is_a HGNC:12841 ! YES1 [Term] -id: FPLX:SREBF +id: FPLX:000452 name: SREBF synonym: "SREBF family" EXACT [] synonym: "SREBF" EXACT [] @@ -7548,12 +7568,12 @@ xref: RE:R-HSA-1655726 xref: RE:R-HSA-1655730 xref: RE:R-HSA-1655732 xref: RE:R-HSA-1655734 -is_a: FPLX:root -inverse_is_a: HGNC:SREBF1 -inverse_is_a: HGNC:SREBF2 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:11289 ! SREBF1 +relationship: inverse_is_a HGNC:11290 ! SREBF2 [Term] -id: FPLX:STAT +id: FPLX:000453 name: STAT synonym: "STAT" EXACT [] synonym: "STATs" EXACT [] @@ -7567,16 +7587,16 @@ xref: IP:IPR015988 xref: MEDSCAN:urn:agi-aopfc:0000163 xref: MEDSCAN:urn:agi-complex:prophash-2de597c3f4a807f3caeaf02e5f93ce15 xref: NCIT:C19618 -is_a: FPLX:root -inverse_is_a: HGNC:STAT1 -inverse_is_a: HGNC:STAT2 -inverse_is_a: HGNC:STAT3 -inverse_is_a: HGNC:STAT4 -inverse_is_a: HGNC:STAT6 -inverse_is_a: FPLX:STAT5 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:11362 ! STAT1 +relationship: inverse_is_a HGNC:11363 ! STAT2 +relationship: inverse_is_a HGNC:11364 ! STAT3 +relationship: inverse_is_a HGNC:11365 ! STAT4 +relationship: inverse_is_a HGNC:11368 ! STAT6 +relationship: inverse_is_a FPLX:000454 ! STAT5 [Term] -id: FPLX:STAT5 +id: FPLX:000454 name: STAT5 synonym: "STAT5" EXACT [] synonym: "Stat5" EXACT [] @@ -7588,20 +7608,20 @@ xref: RE:R-HSA-507919 xref: RE:R-HSA-507929 xref: RE:R-HSA-508012 xref: RE:R-HSA-8865622 -is_a: FPLX:STAT -inverse_is_a: HGNC:STAT5A -inverse_is_a: HGNC:STAT5B +is_a: FPLX:000453 ! STAT +relationship: inverse_is_a HGNC:11366 ! STAT5A +relationship: inverse_is_a HGNC:11367 ! STAT5B [Term] -id: FPLX:STT3 +id: FPLX:000455 name: STT3 synonym: "STT3" EXACT [] -is_a: FPLX:Glycosyltransferase -inverse_is_a: HGNC:STT3A -inverse_is_a: HGNC:STT3B +is_a: FPLX:000198 ! Glycosyltransferase +relationship: inverse_is_a HGNC:6172 ! STT3A +relationship: inverse_is_a HGNC:30611 ! STT3B [Term] -id: FPLX:Sulfonylurea_receptor +id: FPLX:000456 name: Sulfonylurea-receptor synonym: "Sulfonylurea Receptor" EXACT [] synonym: "sulfonylurea receptor" EXACT [] @@ -7610,12 +7630,12 @@ synonym: "SUR" EXACT [] xref: BEL:"Sulfonylurea Receptor Family" xref: GO:0008281 xref: IP:IPR000388 -is_a: FPLX:root -inverse_is_a: HGNC:ABCC8 -inverse_is_a: HGNC:ABCC9 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:59 ! ABCC8 +relationship: inverse_is_a HGNC:60 ! ABCC9 [Term] -id: FPLX:SWI_SNF +id: FPLX:000457 name: SWI-SNF synonym: "SWI and SNF complex" EXACT [] synonym: "SWI/SNF complex" EXACT [] @@ -7626,47 +7646,47 @@ xref: MEDSCAN:urn:agi-complex:prophash-f7a9dc05e48afd7a93466cfbd5504861 xref: MEDSCAN:urn:agi-protfc:chromatin%20remodeling%20complex xref: MEDSCAN:urn:agi-protfc:SWI%2fSNF%20family xref: NCIT:C20591 -is_a: FPLX:root -has_part: HGNC:ARID1A -has_part: HGNC:ARID1B -has_part: HGNC:SMARCA1 -has_part: HGNC:SMARCA2 -has_part: HGNC:SMARCA4 -has_part: HGNC:SMARCA5 -has_part: HGNC:SMARCB1 -has_part: HGNC:SMARCC1 -has_part: HGNC:SMARCC2 -has_part: HGNC:SMARCD1 -has_part: HGNC:SMARCD2 -has_part: HGNC:SMARCD3 -has_part: HGNC:SMARCE1 -has_part: HGNC:ACTL6A -has_part: HGNC:ACTL6B -has_part: HGNC:HLTF - -[Term] -id: FPLX:TAOK +is_a: FPLX:000000 ! famplex +relationship: has_part HGNC:11110 ! ARID1A +relationship: has_part HGNC:18040 ! ARID1B +relationship: has_part HGNC:11097 ! SMARCA1 +relationship: has_part HGNC:11098 ! SMARCA2 +relationship: has_part HGNC:11100 ! SMARCA4 +relationship: has_part HGNC:11101 ! SMARCA5 +relationship: has_part HGNC:11103 ! SMARCB1 +relationship: has_part HGNC:11104 ! SMARCC1 +relationship: has_part HGNC:11105 ! SMARCC2 +relationship: has_part HGNC:11106 ! SMARCD1 +relationship: has_part HGNC:11107 ! SMARCD2 +relationship: has_part HGNC:11108 ! SMARCD3 +relationship: has_part HGNC:11109 ! SMARCE1 +relationship: has_part HGNC:24124 ! ACTL6A +relationship: has_part HGNC:160 ! ACTL6B +relationship: has_part HGNC:11099 ! HLTF + +[Term] +id: FPLX:000458 name: TAOK xref: SIGNOR:SIGNOR-PF21 -is_a: FPLX:MAP3K -inverse_is_a: HGNC:TAOK1 -inverse_is_a: HGNC:TAOK2 -inverse_is_a: HGNC:TAOK3 +is_a: FPLX:000282 ! MAP3K +relationship: inverse_is_a HGNC:29259 ! TAOK1 +relationship: inverse_is_a HGNC:16835 ! TAOK2 +relationship: inverse_is_a HGNC:18133 ! TAOK3 [Term] -id: FPLX:TAP +id: FPLX:000459 name: TAP synonym: "TAP transporter" EXACT [] synonym: "TAP" EXACT [] xref: BEL:"TAP Family" xref: GO:0042825 -is_a: FPLX:root -inverse_is_a: HGNC:TAP1 -inverse_is_a: HGNC:TAP2 -inverse_is_a: HGNC:ABCB9 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:43 ! TAP1 +relationship: inverse_is_a HGNC:44 ! TAP2 +relationship: inverse_is_a HGNC:50 ! ABCB9 [Term] -id: FPLX:TCF_LEF +id: FPLX:000460 name: TCF-LEF synonym: "T-cell factor (TCF)/lymphoid enhancer factor" EXACT [] synonym: "TCF" EXACT [] @@ -7680,36 +7700,36 @@ xref: RE:R-HSA-3299546 xref: RE:R-HSA-5323539 xref: RE:R-HSA-8944354 xref: RE:R-HSA-8951427 -is_a: FPLX:root -inverse_is_a: HGNC:LEF1 -inverse_is_a: HGNC:TCF7 -inverse_is_a: HGNC:TCF7L1 -inverse_is_a: HGNC:TCF7L2 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:6551 ! LEF1 +relationship: inverse_is_a HGNC:11639 ! TCF7 +relationship: inverse_is_a HGNC:11640 ! TCF7L1 +relationship: inverse_is_a HGNC:11641 ! TCF7L2 [Term] -id: FPLX:TCR +id: FPLX:000461 name: TCR synonym: "TCR" EXACT [] xref: MESH:D011948 xref: NCIT:C17065 -is_a: FPLX:root -has_part: HGNC:TRA -has_part: HGNC:TRB -has_part: HGNC:TRD -has_part: HGNC:TRG +is_a: FPLX:000000 ! famplex +relationship: has_part HGNC:12027 ! TRA +relationship: has_part HGNC:12155 ! TRB +relationship: has_part HGNC:12252 ! TRD +relationship: has_part HGNC:12271 ! TRG [Term] -id: FPLX:TEAD +id: FPLX:000462 name: TEAD xref: SIGNOR:SIGNOR-PF22 -is_a: FPLX:root -inverse_is_a: HGNC:TEAD1 -inverse_is_a: HGNC:TEAD2 -inverse_is_a: HGNC:TEAD3 -inverse_is_a: HGNC:TEAD4 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:11714 ! TEAD1 +relationship: inverse_is_a HGNC:11715 ! TEAD2 +relationship: inverse_is_a HGNC:11716 ! TEAD3 +relationship: inverse_is_a HGNC:11717 ! TEAD4 [Term] -id: FPLX:TFAP2 +id: FPLX:000463 name: TFAP2 synonym: "AP-2 transcription factor" EXACT [] synonym: "Transcription factor AP-2" EXACT [] @@ -7720,27 +7740,27 @@ xref: IP:IPR013854 xref: NEXTPROT-FAMILY:00209 xref: RE:R-HSA-8864283 xref: RE:R-HSA-8864286 -is_a: FPLX:root -inverse_is_a: HGNC:TFAP2A -inverse_is_a: HGNC:TFAP2B -inverse_is_a: HGNC:TFAP2C -inverse_is_a: HGNC:TFAP2D -inverse_is_a: HGNC:TFAP2E +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:11742 ! TFAP2A +relationship: inverse_is_a HGNC:11743 ! TFAP2B +relationship: inverse_is_a HGNC:11744 ! TFAP2C +relationship: inverse_is_a HGNC:15581 ! TFAP2D +relationship: inverse_is_a HGNC:30774 ! TFAP2E [Term] -id: FPLX:TFDP +id: FPLX:000464 name: TFDP synonym: "DP complex" EXACT [] synonym: "TFDP" EXACT [] synonym: "transcription factor DP" EXACT [] xref: BEL:"TFDP Family" xref: RE:R-HSA-1362227 -is_a: FPLX:root -inverse_is_a: HGNC:TFDP1 -inverse_is_a: HGNC:TFDP2 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:11749 ! TFDP1 +relationship: inverse_is_a HGNC:11751 ! TFDP2 [Term] -id: FPLX:TGFB +id: FPLX:000465 name: TGFB synonym: "TGF beta" EXACT [] synonym: "TGF β" EXACT [] @@ -7764,13 +7784,13 @@ xref: NEXTPROT-FAMILY:03989 xref: RE:R-HSA-114657 xref: RE:R-HSA-2395330 xref: SIGNOR:SIGNOR-PF5 -is_a: FPLX:root -inverse_is_a: HGNC:TGFB1 -inverse_is_a: HGNC:TGFB2 -inverse_is_a: HGNC:TGFB3 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:11766 ! TGFB1 +relationship: inverse_is_a HGNC:11768 ! TGFB2 +relationship: inverse_is_a HGNC:11769 ! TGFB3 [Term] -id: FPLX:TGFBR +id: FPLX:000466 name: TGFBR synonym: "TGF beta receptor" EXACT [] synonym: "TGF β receptor" EXACT [] @@ -7784,13 +7804,13 @@ synonym: "TGFβ receptor" EXACT [] synonym: "TGFβ receptors" EXACT [] xref: MEDSCAN:urn:agi-aopfc:0000294 xref: MEDSCAN:urn:agi-complex:prophash-9e456bf1de2c5eb1107156c96a1450e6 -is_a: FPLX:root -inverse_is_a: HGNC:TGFBR1 -inverse_is_a: HGNC:TGFBR2 -inverse_is_a: HGNC:TGFBR3 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:11772 ! TGFBR1 +relationship: inverse_is_a HGNC:11773 ! TGFBR2 +relationship: inverse_is_a HGNC:11774 ! TGFBR3 [Term] -id: FPLX:THBS +id: FPLX:000467 name: THBS synonym: "thrombospondin protein" EXACT [] synonym: "Thrombospondin" EXACT [] @@ -7803,75 +7823,75 @@ xref: IP:IPR008859 xref: IP:IPR017897 xref: IP:IPR028974 xref: MEDSCAN:urn:agi-protfc:thrombospondins -is_a: FPLX:root -inverse_is_a: HGNC:THBS1 -inverse_is_a: HGNC:THBS2 -inverse_is_a: HGNC:THBS3 -inverse_is_a: HGNC:THBS4 -inverse_is_a: HGNC:COMP +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:11785 ! THBS1 +relationship: inverse_is_a HGNC:11786 ! THBS2 +relationship: inverse_is_a HGNC:11787 ! THBS3 +relationship: inverse_is_a HGNC:11788 ! THBS4 +relationship: inverse_is_a HGNC:2227 ! COMP [Term] -id: FPLX:THR +id: FPLX:000468 name: THR synonym: "thyroid hormone receptor" EXACT [] xref: BEL:"THR Family" xref: NCIT:C17078 -is_a: FPLX:root -inverse_is_a: HGNC:THRA -inverse_is_a: HGNC:THRB +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:11796 ! THRA +relationship: inverse_is_a HGNC:11799 ! THRB [Term] -id: FPLX:Thrombin_antithrombin +id: FPLX:000469 name: Thrombin-antithrombin synonym: "thrombin-anti-thrombin III complexes" EXACT [] xref: BEL:"Thrombin Antithrombin Complex" xref: RE:R-HSA-140812 xref: RE:R-HSA-140871 xref: RE:R-HSA-140874 -is_a: FPLX:root -has_part: HGNC:F2 -has_part: HGNC:SERPINC1 +is_a: FPLX:000000 ! famplex +relationship: has_part HGNC:3535 ! F2 +relationship: has_part HGNC:775 ! SERPINC1 [Term] -id: FPLX:TIAM +id: FPLX:000470 name: TIAM synonym: "TIAM" EXACT [] xref: NEXTPROT-FAMILY:04014 -is_a: FPLX:root -inverse_is_a: HGNC:TIAM1 -inverse_is_a: HGNC:TIAM2 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:11805 ! TIAM1 +relationship: inverse_is_a HGNC:11806 ! TIAM2 [Term] -id: FPLX:TIF_IB +id: FPLX:000471 name: TIF-IB synonym: "TIF-IB" EXACT [] xref: BEL:"TIF IB Complex" -is_a: FPLX:root -has_part: HGNC:TAF1A -has_part: HGNC:TAF1B -has_part: HGNC:TAF1C -has_part: HGNC:TBP +is_a: FPLX:000000 ! famplex +relationship: has_part HGNC:11532 ! TAF1A +relationship: has_part HGNC:11533 ! TAF1B +relationship: has_part HGNC:11534 ! TAF1C +relationship: has_part HGNC:11588 ! TBP [Term] -id: FPLX:TLR +id: FPLX:000472 name: TLR synonym: "TLR" EXACT [] xref: MEDSCAN:urn:agi-aopfc:0000296 xref: SIGNOR:SIGNOR-PF20 -is_a: FPLX:root -inverse_is_a: HGNC:TLR1 -inverse_is_a: HGNC:TLR2 -inverse_is_a: HGNC:TLR3 -inverse_is_a: HGNC:TLR4 -inverse_is_a: HGNC:TLR5 -inverse_is_a: HGNC:TLR6 -inverse_is_a: HGNC:TLR7 -inverse_is_a: HGNC:TLR8 -inverse_is_a: HGNC:TLR9 -inverse_is_a: HGNC:TLR10 - -[Term] -id: FPLX:TN +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:11847 ! TLR1 +relationship: inverse_is_a HGNC:11848 ! TLR2 +relationship: inverse_is_a HGNC:11849 ! TLR3 +relationship: inverse_is_a HGNC:11850 ! TLR4 +relationship: inverse_is_a HGNC:11851 ! TLR5 +relationship: inverse_is_a HGNC:16711 ! TLR6 +relationship: inverse_is_a HGNC:15631 ! TLR7 +relationship: inverse_is_a HGNC:15632 ! TLR8 +relationship: inverse_is_a HGNC:15633 ! TLR9 +relationship: inverse_is_a HGNC:15634 ! TLR10 + +[Term] +id: FPLX:000473 name: TN synonym: "Tenascin" EXACT [] synonym: "tenascin" EXACT [] @@ -7880,21 +7900,21 @@ xref: NCIT:C104676 xref: NEXTPROT-FAMILY:03964 xref: RE:R-HSA-2672035 xref: RE:R-HSA-2681744 -is_a: FPLX:root -inverse_is_a: HGNC:TNC -inverse_is_a: HGNC:TNN -inverse_is_a: HGNC:TNR -inverse_is_a: HGNC:TNXB +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:5318 ! TNC +relationship: inverse_is_a HGNC:22942 ! TNN +relationship: inverse_is_a HGNC:11953 ! TNR +relationship: inverse_is_a HGNC:11976 ! TNXB [Term] -id: FPLX:TNF +id: FPLX:000474 name: TNF xref: NEXTPROT-FAMILY:04243 xref: XFAM:PF00229 -is_a: FPLX:root +is_a: FPLX:000000 ! famplex [Term] -id: FPLX:TNFRSF +id: FPLX:000475 name: TNFRSF synonym: "TNF-R superfamily" EXACT [] synonym: "TNF-receptor family" EXACT [] @@ -7906,30 +7926,30 @@ synonym: "TNFR superfamily" EXACT [] synonym: "TNFR" EXACT [] xref: BEL:"TNFRSF Family" xref: MEDSCAN:urn:agi-aopfc:0000295 -is_a: FPLX:root -inverse_is_a: HGNC:TNFRSF1A -inverse_is_a: HGNC:TNFRSF1B -inverse_is_a: HGNC:TNFRSF4 -inverse_is_a: HGNC:TNFRSF8 -inverse_is_a: HGNC:TNFRSF9 -inverse_is_a: HGNC:TNFRSF10A -inverse_is_a: HGNC:TNFRSF10B -inverse_is_a: HGNC:TNFRSF10C -inverse_is_a: HGNC:TNFRSF10D -inverse_is_a: HGNC:TNFRSF11A -inverse_is_a: HGNC:TNFRSF11B -inverse_is_a: HGNC:TNFRSF12A -inverse_is_a: HGNC:TNFRSF13B -inverse_is_a: HGNC:TNFRSF13C -inverse_is_a: HGNC:TNFRSF14 -inverse_is_a: HGNC:TNFRSF17 -inverse_is_a: HGNC:TNFRSF18 -inverse_is_a: HGNC:TNFRSF19 -inverse_is_a: HGNC:TNFRSF21 -inverse_is_a: HGNC:TNFRSF25 - -[Term] -id: FPLX:TOP2 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:11916 ! TNFRSF1A +relationship: inverse_is_a HGNC:11917 ! TNFRSF1B +relationship: inverse_is_a HGNC:11918 ! TNFRSF4 +relationship: inverse_is_a HGNC:11923 ! TNFRSF8 +relationship: inverse_is_a HGNC:11924 ! TNFRSF9 +relationship: inverse_is_a HGNC:11904 ! TNFRSF10A +relationship: inverse_is_a HGNC:11905 ! TNFRSF10B +relationship: inverse_is_a HGNC:11906 ! TNFRSF10C +relationship: inverse_is_a HGNC:11907 ! TNFRSF10D +relationship: inverse_is_a HGNC:11908 ! TNFRSF11A +relationship: inverse_is_a HGNC:11909 ! TNFRSF11B +relationship: inverse_is_a HGNC:18152 ! TNFRSF12A +relationship: inverse_is_a HGNC:18153 ! TNFRSF13B +relationship: inverse_is_a HGNC:17755 ! TNFRSF13C +relationship: inverse_is_a HGNC:11912 ! TNFRSF14 +relationship: inverse_is_a HGNC:11913 ! TNFRSF17 +relationship: inverse_is_a HGNC:11914 ! TNFRSF18 +relationship: inverse_is_a HGNC:11915 ! TNFRSF19 +relationship: inverse_is_a HGNC:13469 ! TNFRSF21 +relationship: inverse_is_a HGNC:11910 ! TNFRSF25 + +[Term] +id: FPLX:000476 name: TOP2 synonym: "topoisomerase II" EXACT [] xref: BEL:"TOP2 Family" @@ -7947,12 +7967,12 @@ xref: IP:IPR024946 xref: IP:IPR031660 xref: IP:IPR034157 xref: NCIT:C18434 -is_a: FPLX:root -inverse_is_a: HGNC:TOP2A -inverse_is_a: HGNC:TOP2B +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:11989 ! TOP2A +relationship: inverse_is_a HGNC:11990 ! TOP2B [Term] -id: FPLX:Troponin +id: FPLX:000477 name: Troponin synonym: "troponin complex" EXACT [] synonym: "troponin" EXACT [] @@ -7961,13 +7981,13 @@ xref: GO:0005861 xref: MEDSCAN:urn:agi-complex:prophash-e4ec238e69c3d3292966ac97dbc11086 xref: RE:R-HSA-390583 xref: RE:R-HSA-390585 -is_a: FPLX:root -has_part: FPLX:Troponin_C -has_part: FPLX:Troponin_I -has_part: FPLX:Troponin_T +is_a: FPLX:000000 ! famplex +relationship: has_part FPLX:000478 ! Troponin_C +relationship: has_part FPLX:000479 ! Troponin_I +relationship: has_part FPLX:000480 ! Troponin_T [Term] -id: FPLX:Troponin_C +id: FPLX:000478 name: Troponin-C synonym: "cTnC" EXACT [] synonym: "cTnI" EXACT [] @@ -7976,24 +7996,24 @@ synonym: "TnC" EXACT [] synonym: "troponin C" EXACT [] xref: RE:R-HSA-390532 xref: RE:R-HSA-390587 -part_of: FPLX:Troponin -inverse_is_a: HGNC:TNNC1 -inverse_is_a: HGNC:TNNC2 +relationship: part_of FPLX:000477 ! Troponin +relationship: inverse_is_a HGNC:11943 ! TNNC1 +relationship: inverse_is_a HGNC:11944 ! TNNC2 [Term] -id: FPLX:Troponin_I +id: FPLX:000479 name: Troponin-I synonym: "TPNI" EXACT [] synonym: "troponin I" EXACT [] xref: NCIT:C17343 xref: RE:R-HSA-390541 -part_of: FPLX:Troponin -inverse_is_a: HGNC:TNNI1 -inverse_is_a: HGNC:TNNI2 -inverse_is_a: HGNC:TNNI3 +relationship: part_of FPLX:000477 ! Troponin +relationship: inverse_is_a HGNC:11945 ! TNNI1 +relationship: inverse_is_a HGNC:11946 ! TNNI2 +relationship: inverse_is_a HGNC:11947 ! TNNI3 [Term] -id: FPLX:Troponin_T +id: FPLX:000480 name: Troponin-T synonym: "cTnT" EXACT [] synonym: "TPNT" EXACT [] @@ -8001,13 +8021,13 @@ synonym: "troponin T" EXACT [] xref: IP:IPR027707 xref: NCIT:C38041 xref: RE:R-HSA-390546 -part_of: FPLX:Troponin -inverse_is_a: HGNC:TNNT1 -inverse_is_a: HGNC:TNNT2 -inverse_is_a: HGNC:TNNT3 +relationship: part_of FPLX:000477 ! Troponin +relationship: inverse_is_a HGNC:11948 ! TNNT1 +relationship: inverse_is_a HGNC:11949 ! TNNT2 +relationship: inverse_is_a HGNC:11950 ! TNNT3 [Term] -id: FPLX:Tryptase +id: FPLX:000481 name: Tryptase synonym: "Tryptase" EXACT [] synonym: "tryptase" EXACT [] @@ -8016,26 +8036,26 @@ xref: BEL:"Tryptase Family" xref: ECCODE:3.4.21.59 xref: NCIT:C120030 xref: NEXTPROT-FAMILY:02767 -is_a: FPLX:root -inverse_is_a: HGNC:TPSAB1 -inverse_is_a: HGNC:TPSB2 -inverse_is_a: HGNC:TPSD1 -inverse_is_a: HGNC:TPSG1 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:12019 ! TPSAB1 +relationship: inverse_is_a HGNC:14120 ! TPSB2 +relationship: inverse_is_a HGNC:14118 ! TPSD1 +relationship: inverse_is_a HGNC:14134 ! TPSG1 [Term] -id: FPLX:TSC +id: FPLX:000482 name: TSC synonym: "TSC" EXACT [] xref: RE:R-HSA-165175 xref: RE:R-HSA-165180 xref: RE:R-HSA-381855 xref: RE:R-HSA-5672337 -is_a: FPLX:root -inverse_is_a: HGNC:TSC1 -inverse_is_a: HGNC:TSC2 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:12362 ! TSC1 +relationship: inverse_is_a HGNC:12363 ! TSC2 [Term] -id: FPLX:TUBA +id: FPLX:000483 name: TUBA synonym: "alpha tubulin" EXACT [] synonym: "TUBA" EXACT [] @@ -8043,19 +8063,19 @@ synonym: "tubulin alpha chain" EXACT [] synonym: "tubulin α chain" EXACT [] synonym: "α tubulin" EXACT [] xref: BEL:"TUBA Family" -is_a: FPLX:Tubulin -inverse_is_a: HGNC:TUBA1A -inverse_is_a: HGNC:TUBA1B -inverse_is_a: HGNC:TUBA1C -inverse_is_a: HGNC:TUBA3C -inverse_is_a: HGNC:TUBA3D -inverse_is_a: HGNC:TUBA3E -inverse_is_a: HGNC:TUBA4A -inverse_is_a: HGNC:TUBA8 -inverse_is_a: HGNC:TUBAL3 - -[Term] -id: FPLX:TUBB +is_a: FPLX:000486 ! Tubulin +relationship: inverse_is_a HGNC:20766 ! TUBA1A +relationship: inverse_is_a HGNC:18809 ! TUBA1B +relationship: inverse_is_a HGNC:20768 ! TUBA1C +relationship: inverse_is_a HGNC:12408 ! TUBA3C +relationship: inverse_is_a HGNC:24071 ! TUBA3D +relationship: inverse_is_a HGNC:20765 ! TUBA3E +relationship: inverse_is_a HGNC:12407 ! TUBA4A +relationship: inverse_is_a HGNC:12410 ! TUBA8 +relationship: inverse_is_a HGNC:23534 ! TUBAL3 + +[Term] +id: FPLX:000484 name: TUBB synonym: "Beta Tubulin" EXACT [] synonym: "Beta tubulin" EXACT [] @@ -8073,18 +8093,18 @@ synonym: "tubulin β" EXACT [] xref: BEL:"TUBB Family" xref: IP:IPR002453 xref: NCIT:C129655 -is_a: FPLX:Tubulin -inverse_is_a: HGNC:TUBB -inverse_is_a: HGNC:TUBB1 -inverse_is_a: HGNC:TUBB2A -inverse_is_a: HGNC:TUBB2B -inverse_is_a: HGNC:TUBB3 -inverse_is_a: HGNC:TUBB4A -inverse_is_a: HGNC:TUBB4B -inverse_is_a: HGNC:TUBB6 - -[Term] -id: FPLX:TUBG +is_a: FPLX:000486 ! Tubulin +relationship: inverse_is_a HGNC:20778 ! TUBB +relationship: inverse_is_a HGNC:16257 ! TUBB1 +relationship: inverse_is_a HGNC:12412 ! TUBB2A +relationship: inverse_is_a HGNC:30829 ! TUBB2B +relationship: inverse_is_a HGNC:20772 ! TUBB3 +relationship: inverse_is_a HGNC:20774 ! TUBB4A +relationship: inverse_is_a HGNC:20771 ! TUBB4B +relationship: inverse_is_a HGNC:20776 ! TUBB6 + +[Term] +id: FPLX:000485 name: TUBG synonym: "Gamma tubulin" EXACT [] synonym: "gamma tubulin" EXACT [] @@ -8095,27 +8115,27 @@ synonym: "γ tubulin" EXACT [] synonym: "γ-tubulin" EXACT [] xref: GO:0000930 xref: IP:IPR002454 -is_a: FPLX:Tubulin -inverse_is_a: HGNC:TUBG1 -inverse_is_a: HGNC:TUBG2 +is_a: FPLX:000486 ! Tubulin +relationship: inverse_is_a HGNC:12417 ! TUBG1 +relationship: inverse_is_a HGNC:12419 ! TUBG2 [Term] -id: FPLX:Tubulin +id: FPLX:000486 name: Tubulin synonym: "tubulin" EXACT [] xref: MEDSCAN:urn:agi-complex:prophash-90a087d4e73b3992c65edfd9f71c6802 xref: MEDSCAN:urn:agi-protfc:tubulin xref: NCIT:C17219 xref: NEXTPROT-FAMILY:04239 -is_a: FPLX:root -inverse_is_a: FPLX:TUBA -inverse_is_a: FPLX:TUBB -inverse_is_a: FPLX:TUBG -inverse_is_a: HGNC:TUBD1 -inverse_is_a: HGNC:TUBE1 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a FPLX:000483 ! TUBA +relationship: inverse_is_a FPLX:000484 ! TUBB +relationship: inverse_is_a FPLX:000485 ! TUBG +relationship: inverse_is_a HGNC:16811 ! TUBD1 +relationship: inverse_is_a HGNC:20775 ! TUBE1 [Term] -id: FPLX:TXN +id: FPLX:000487 name: TXN synonym: "Thioredoxin" EXACT [] synonym: "thioredoxin" EXACT [] @@ -8123,24 +8143,24 @@ synonym: "thioredoxins" EXACT [] xref: BEL:"TXN Family" xref: MEDSCAN:urn:agi-protfc:thioredoxin xref: NEXTPROT-FAMILY:04000 -is_a: FPLX:root -inverse_is_a: HGNC:TXN -inverse_is_a: HGNC:TXN2 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:12435 ! TXN +relationship: inverse_is_a HGNC:17772 ! TXN2 [Term] -id: FPLX:TXNRD +id: FPLX:000488 name: TXNRD synonym: "Thioredoxin reductase" EXACT [] synonym: "thioredoxin reductase" EXACT [] xref: BEL:"TXNRD Family" xref: IP:IPR006338 -is_a: FPLX:root -inverse_is_a: HGNC:TXNRD1 -inverse_is_a: HGNC:TXNRD2 -inverse_is_a: HGNC:TXNRD3 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:12437 ! TXNRD1 +relationship: inverse_is_a HGNC:18155 ! TXNRD2 +relationship: inverse_is_a HGNC:20667 ! TXNRD3 [Term] -id: FPLX:UBE2 +id: FPLX:000489 name: UBE2 synonym: "E2 enzyme" EXACT [] synonym: "E2 ubiquitin-conjugating enzyme" EXACT [] @@ -8152,39 +8172,39 @@ xref: BEL:"UBE2 Family" xref: ECCODE:2.3.2.23 xref: GO:0019787 xref: NEXTPROT-FAMILY:04282 -is_a: FPLX:root -inverse_is_a: HGNC:CDC34 -inverse_is_a: HGNC:UBE2A -inverse_is_a: HGNC:UBE2B -inverse_is_a: HGNC:UBE2C -inverse_is_a: HGNC:UBE2D1 -inverse_is_a: HGNC:UBE2D2 -inverse_is_a: HGNC:UBE2D3 -inverse_is_a: HGNC:UBE2D4 -inverse_is_a: HGNC:UBE2E1 -inverse_is_a: HGNC:UBE2E2 -inverse_is_a: HGNC:UBE2E3 -inverse_is_a: HGNC:UBE2F -inverse_is_a: HGNC:UBE2G1 -inverse_is_a: HGNC:UBE2G2 -inverse_is_a: HGNC:UBE2H -inverse_is_a: HGNC:UBE2I -inverse_is_a: HGNC:UBE2J1 -inverse_is_a: HGNC:UBE2J2 -inverse_is_a: HGNC:UBE2L3 -inverse_is_a: HGNC:UBE2L6 -inverse_is_a: HGNC:UBE2M -inverse_is_a: HGNC:UBE2N -inverse_is_a: HGNC:UBE2NL -inverse_is_a: HGNC:UBE2Q1 -inverse_is_a: HGNC:UBE2R2 -inverse_is_a: HGNC:UBE2S -inverse_is_a: HGNC:UBE2V1 -inverse_is_a: HGNC:UBE2V2 -inverse_is_a: HGNC:UBE2W - -[Term] -id: FPLX:Ubiquitin +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:1734 ! CDC34 +relationship: inverse_is_a HGNC:12472 ! UBE2A +relationship: inverse_is_a HGNC:12473 ! UBE2B +relationship: inverse_is_a HGNC:15937 ! UBE2C +relationship: inverse_is_a HGNC:12474 ! UBE2D1 +relationship: inverse_is_a HGNC:12475 ! UBE2D2 +relationship: inverse_is_a HGNC:12476 ! UBE2D3 +relationship: inverse_is_a HGNC:21647 ! UBE2D4 +relationship: inverse_is_a HGNC:12477 ! UBE2E1 +relationship: inverse_is_a HGNC:12478 ! UBE2E2 +relationship: inverse_is_a HGNC:12479 ! UBE2E3 +relationship: inverse_is_a HGNC:12480 ! UBE2F +relationship: inverse_is_a HGNC:12482 ! UBE2G1 +relationship: inverse_is_a HGNC:12483 ! UBE2G2 +relationship: inverse_is_a HGNC:12484 ! UBE2H +relationship: inverse_is_a HGNC:12485 ! UBE2I +relationship: inverse_is_a HGNC:17598 ! UBE2J1 +relationship: inverse_is_a HGNC:19268 ! UBE2J2 +relationship: inverse_is_a HGNC:12488 ! UBE2L3 +relationship: inverse_is_a HGNC:12490 ! UBE2L6 +relationship: inverse_is_a HGNC:12491 ! UBE2M +relationship: inverse_is_a HGNC:12492 ! UBE2N +relationship: inverse_is_a HGNC:31710 ! UBE2NL +relationship: inverse_is_a HGNC:15698 ! UBE2Q1 +relationship: inverse_is_a HGNC:19907 ! UBE2R2 +relationship: inverse_is_a HGNC:17895 ! UBE2S +relationship: inverse_is_a HGNC:12494 ! UBE2V1 +relationship: inverse_is_a HGNC:12495 ! UBE2V2 +relationship: inverse_is_a HGNC:25616 ! UBE2W + +[Term] +id: FPLX:000490 name: Ubiquitin synonym: "Ub" EXACT [] synonym: "ub" EXACT [] @@ -8194,61 +8214,61 @@ xref: MEDSCAN:urn:agi-complex:prophash-50bd08479c3770278693a51fe379babd xref: MEDSCAN:urn:agi-protfc:ubiquitin xref: NCIT:C17227 xref: NEXTPROT-FAMILY:04276 -is_a: FPLX:root +is_a: FPLX:000000 ! famplex [Term] -id: FPLX:UGCG +id: FPLX:000491 name: UGCG -is_a: FPLX:Glycosyltransferase -inverse_is_a: HGNC:UGCG +is_a: FPLX:000198 ! Glycosyltransferase +relationship: inverse_is_a HGNC:12524 ! UGCG [Term] -id: FPLX:UGT +id: FPLX:000492 name: UGT synonym: "UGT" EXACT [] -is_a: FPLX:Glycosyltransferase -inverse_is_a: HGNC:UGT1A -inverse_is_a: HGNC:UGT1A1 -inverse_is_a: HGNC:UGT1A2P -inverse_is_a: HGNC:UGT1A3 -inverse_is_a: HGNC:UGT1A4 -inverse_is_a: HGNC:UGT1A5 -inverse_is_a: HGNC:UGT1A6 -inverse_is_a: HGNC:UGT1A7 -inverse_is_a: HGNC:UGT1A8 -inverse_is_a: HGNC:UGT1A9 -inverse_is_a: HGNC:UGT1A10 -inverse_is_a: HGNC:UGT1A11P -inverse_is_a: HGNC:UGT1A12P -inverse_is_a: HGNC:UGT1A13P -inverse_is_a: HGNC:UGT2A1 -inverse_is_a: HGNC:UGT2A2 -inverse_is_a: HGNC:UGT2A3 -inverse_is_a: HGNC:UGT2B4 -inverse_is_a: HGNC:UGT2B7 -inverse_is_a: HGNC:UGT2B10 -inverse_is_a: HGNC:UGT2B11 -inverse_is_a: HGNC:UGT2B15 -inverse_is_a: HGNC:UGT2B17 -inverse_is_a: HGNC:UGT2B24P -inverse_is_a: HGNC:UGT2B25P -inverse_is_a: HGNC:UGT2B26P -inverse_is_a: HGNC:UGT2B27P -inverse_is_a: HGNC:UGT2B28 -inverse_is_a: HGNC:UGT2B29P -inverse_is_a: HGNC:UGT3A1 -inverse_is_a: HGNC:UGT3A2 -inverse_is_a: HGNC:UGT8 - -[Term] -id: FPLX:UGGT +is_a: FPLX:000198 ! Glycosyltransferase +relationship: inverse_is_a HGNC:12529 ! UGT1A +relationship: inverse_is_a HGNC:12530 ! UGT1A1 +relationship: inverse_is_a HGNC:12534 ! UGT1A2P +relationship: inverse_is_a HGNC:12535 ! UGT1A3 +relationship: inverse_is_a HGNC:12536 ! UGT1A4 +relationship: inverse_is_a HGNC:12537 ! UGT1A5 +relationship: inverse_is_a HGNC:12538 ! UGT1A6 +relationship: inverse_is_a HGNC:12539 ! UGT1A7 +relationship: inverse_is_a HGNC:12540 ! UGT1A8 +relationship: inverse_is_a HGNC:12541 ! UGT1A9 +relationship: inverse_is_a HGNC:12531 ! UGT1A10 +relationship: inverse_is_a HGNC:12532 ! UGT1A11P +relationship: inverse_is_a HGNC:12533 ! UGT1A12P +relationship: inverse_is_a HGNC:32191 ! UGT1A13P +relationship: inverse_is_a HGNC:12542 ! UGT2A1 +relationship: inverse_is_a HGNC:28183 ! UGT2A2 +relationship: inverse_is_a HGNC:28528 ! UGT2A3 +relationship: inverse_is_a HGNC:12553 ! UGT2B4 +relationship: inverse_is_a HGNC:12554 ! UGT2B7 +relationship: inverse_is_a HGNC:12544 ! UGT2B10 +relationship: inverse_is_a HGNC:12545 ! UGT2B11 +relationship: inverse_is_a HGNC:12546 ! UGT2B15 +relationship: inverse_is_a HGNC:12547 ! UGT2B17 +relationship: inverse_is_a HGNC:12548 ! UGT2B24P +relationship: inverse_is_a HGNC:12549 ! UGT2B25P +relationship: inverse_is_a HGNC:12550 ! UGT2B26P +relationship: inverse_is_a HGNC:12551 ! UGT2B27P +relationship: inverse_is_a HGNC:13479 ! UGT2B28 +relationship: inverse_is_a HGNC:12552 ! UGT2B29P +relationship: inverse_is_a HGNC:26625 ! UGT3A1 +relationship: inverse_is_a HGNC:27266 ! UGT3A2 +relationship: inverse_is_a HGNC:12555 ! UGT8 + +[Term] +id: FPLX:000493 name: UGGT -is_a: FPLX:Glycosyltransferase -inverse_is_a: HGNC:UGGT1 -inverse_is_a: HGNC:UGGT2 +is_a: FPLX:000198 ! Glycosyltransferase +relationship: inverse_is_a HGNC:15663 ! UGGT1 +relationship: inverse_is_a HGNC:15664 ! UGGT2 [Term] -id: FPLX:VAV +id: FPLX:000494 name: VAV synonym: "VAV family" EXACT [] synonym: "Vav" EXACT [] @@ -8261,13 +8281,13 @@ xref: RE:R-HSA-442272 xref: RE:R-HSA-442295 xref: RE:R-HSA-5218789 xref: RE:R-HSA-5340329 -is_a: FPLX:root -inverse_is_a: HGNC:VAV1 -inverse_is_a: HGNC:VAV2 -inverse_is_a: HGNC:VAV3 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:12657 ! VAV1 +relationship: inverse_is_a HGNC:12658 ! VAV2 +relationship: inverse_is_a HGNC:12659 ! VAV3 [Term] -id: FPLX:VEGF +id: FPLX:000495 name: VEGF synonym: "vascular endothelial growth factor" EXACT [] synonym: "VEGF" EXACT [] @@ -8275,15 +8295,15 @@ xref: BEL:"VEGF Family" xref: NCIT:C129646 xref: RE:R-HSA-195361 xref: RE:R-HSA-195376 -is_a: FPLX:root -inverse_is_a: HGNC:VEGFA -inverse_is_a: HGNC:VEGFB -inverse_is_a: HGNC:VEGFC -inverse_is_a: HGNC:VEGFD -inverse_is_a: HGNC:PGF +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:12680 ! VEGFA +relationship: inverse_is_a HGNC:12681 ! VEGFB +relationship: inverse_is_a HGNC:12682 ! VEGFC +relationship: inverse_is_a HGNC:3708 ! VEGFD +relationship: inverse_is_a HGNC:8893 ! PGF [Term] -id: FPLX:VEGFR +id: FPLX:000496 name: VEGFR synonym: "VEGF receptor" EXACT [] synonym: "VEGF receptors" EXACT [] @@ -8293,13 +8313,13 @@ synonym: "VEGFRs" EXACT [] xref: BEL:"VEGFR Family" xref: GO:0005172 xref: NCIT:C17293 -is_a: FPLX:root -inverse_is_a: HGNC:FLT1 -inverse_is_a: HGNC:FLT4 -inverse_is_a: HGNC:KDR +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:3763 ! FLT1 +relationship: inverse_is_a HGNC:3767 ! FLT4 +relationship: inverse_is_a HGNC:6307 ! KDR [Term] -id: FPLX:Wnt +id: FPLX:000497 name: Wnt synonym: "WNT" EXACT [] synonym: "Wnt" EXACT [] @@ -8314,96 +8334,96 @@ xref: RE:R-HSA-3238374 xref: RE:R-HSA-3247790 xref: RE:R-HSA-3247824 xref: RE:R-HSA-3247835 -is_a: FPLX:root -inverse_is_a: HGNC:WNT1 -inverse_is_a: HGNC:WNT2 -inverse_is_a: HGNC:WNT2B -inverse_is_a: HGNC:WNT3 -inverse_is_a: HGNC:WNT3A -inverse_is_a: HGNC:WNT4 -inverse_is_a: HGNC:WNT5A -inverse_is_a: HGNC:WNT5B -inverse_is_a: HGNC:WNT6 -inverse_is_a: HGNC:WNT7A -inverse_is_a: HGNC:WNT7B -inverse_is_a: HGNC:WNT8A -inverse_is_a: HGNC:WNT8B -inverse_is_a: HGNC:WNT9A -inverse_is_a: HGNC:WNT9B -inverse_is_a: HGNC:WNT10A -inverse_is_a: HGNC:WNT10B -inverse_is_a: HGNC:WNT11 -inverse_is_a: HGNC:WNT16 - -[Term] -id: FPLX:YBX +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:12774 ! WNT1 +relationship: inverse_is_a HGNC:12780 ! WNT2 +relationship: inverse_is_a HGNC:12781 ! WNT2B +relationship: inverse_is_a HGNC:12782 ! WNT3 +relationship: inverse_is_a HGNC:15983 ! WNT3A +relationship: inverse_is_a HGNC:12783 ! WNT4 +relationship: inverse_is_a HGNC:12784 ! WNT5A +relationship: inverse_is_a HGNC:16265 ! WNT5B +relationship: inverse_is_a HGNC:12785 ! WNT6 +relationship: inverse_is_a HGNC:12786 ! WNT7A +relationship: inverse_is_a HGNC:12787 ! WNT7B +relationship: inverse_is_a HGNC:12788 ! WNT8A +relationship: inverse_is_a HGNC:12789 ! WNT8B +relationship: inverse_is_a HGNC:12778 ! WNT9A +relationship: inverse_is_a HGNC:12779 ! WNT9B +relationship: inverse_is_a HGNC:13829 ! WNT10A +relationship: inverse_is_a HGNC:12775 ! WNT10B +relationship: inverse_is_a HGNC:12776 ! WNT11 +relationship: inverse_is_a HGNC:16267 ! WNT16 + +[Term] +id: FPLX:000498 name: YBX synonym: "Y box binding protein" EXACT [] synonym: "Y-box-binding protein" EXACT [] synonym: "YBX protein family" EXACT [] -is_a: FPLX:root -inverse_is_a: HGNC:YBX1 -inverse_is_a: HGNC:YBX2 -inverse_is_a: HGNC:YBX3 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:8014 ! YBX1 +relationship: inverse_is_a HGNC:17948 ! YBX2 +relationship: inverse_is_a HGNC:2428 ! YBX3 [Term] -id: FPLX:ETC_complex_I_core +id: FPLX:000499 name: ETC-complex-I-core xref: HGNC_GROUP:1149 -part_of: FPLX:ETC_complex_I -has_part: HGNC:MT-ND1 -has_part: HGNC:MT-ND2 -has_part: HGNC:MT-ND3 -has_part: HGNC:MT-ND4 -has_part: HGNC:MT-ND4L -has_part: HGNC:MT-ND5 -has_part: HGNC:MT-ND6 -has_part: HGNC:NDUFS1 -has_part: HGNC:NDUFS2 -has_part: HGNC:NDUFS3 -has_part: HGNC:NDUFS7 -has_part: HGNC:NDUFS8 -has_part: HGNC:NDUFV1 -has_part: HGNC:NDUFV2 - -[Term] -id: FPLX:ETC_complex_I_supernumerary +relationship: part_of FPLX:000501 ! ETC_complex_I +relationship: has_part HGNC:7455 ! MT-ND1 +relationship: has_part HGNC:7456 ! MT-ND2 +relationship: has_part HGNC:7458 ! MT-ND3 +relationship: has_part HGNC:7459 ! MT-ND4 +relationship: has_part HGNC:7460 ! MT-ND4L +relationship: has_part HGNC:7461 ! MT-ND5 +relationship: has_part HGNC:7462 ! MT-ND6 +relationship: has_part HGNC:7707 ! NDUFS1 +relationship: has_part HGNC:7708 ! NDUFS2 +relationship: has_part HGNC:7710 ! NDUFS3 +relationship: has_part HGNC:7714 ! NDUFS7 +relationship: has_part HGNC:7715 ! NDUFS8 +relationship: has_part HGNC:7716 ! NDUFV1 +relationship: has_part HGNC:7717 ! NDUFV2 + +[Term] +id: FPLX:000500 name: ETC-complex-I-supernumerary xref: HGNC_GROUP:1150 -part_of: FPLX:ETC_complex_I -has_part: HGNC:NDUFAB1 -has_part: HGNC:NDUFA1 -has_part: HGNC:NDUFA2 -has_part: HGNC:NDUFA3 -has_part: HGNC:NDUFA5 -has_part: HGNC:NDUFA6 -has_part: HGNC:NDUFA7 -has_part: HGNC:NDUFA8 -has_part: HGNC:NDUFA9 -has_part: HGNC:NDUFA10 -has_part: HGNC:NDUFA11 -has_part: HGNC:NDUFA12 -has_part: HGNC:NDUFA13 -has_part: HGNC:NDUFB1 -has_part: HGNC:NDUFB2 -has_part: HGNC:NDUFB3 -has_part: HGNC:NDUFB4 -has_part: HGNC:NDUFB5 -has_part: HGNC:NDUFB6 -has_part: HGNC:NDUFB7 -has_part: HGNC:NDUFB8 -has_part: HGNC:NDUFB9 -has_part: HGNC:NDUFB10 -has_part: HGNC:NDUFB11 -has_part: HGNC:NDUFC1 -has_part: HGNC:NDUFC2 -has_part: HGNC:NDUFS4 -has_part: HGNC:NDUFS5 -has_part: HGNC:NDUFS6 -has_part: HGNC:NDUFV3 - -[Term] -id: FPLX:ETC_complex_I +relationship: part_of FPLX:000501 ! ETC_complex_I +relationship: has_part HGNC:7694 ! NDUFAB1 +relationship: has_part HGNC:7683 ! NDUFA1 +relationship: has_part HGNC:7685 ! NDUFA2 +relationship: has_part HGNC:7686 ! NDUFA3 +relationship: has_part HGNC:7688 ! NDUFA5 +relationship: has_part HGNC:7690 ! NDUFA6 +relationship: has_part HGNC:7691 ! NDUFA7 +relationship: has_part HGNC:7692 ! NDUFA8 +relationship: has_part HGNC:7693 ! NDUFA9 +relationship: has_part HGNC:7684 ! NDUFA10 +relationship: has_part HGNC:20371 ! NDUFA11 +relationship: has_part HGNC:23987 ! NDUFA12 +relationship: has_part HGNC:17194 ! NDUFA13 +relationship: has_part HGNC:7695 ! NDUFB1 +relationship: has_part HGNC:7697 ! NDUFB2 +relationship: has_part HGNC:7698 ! NDUFB3 +relationship: has_part HGNC:7699 ! NDUFB4 +relationship: has_part HGNC:7700 ! NDUFB5 +relationship: has_part HGNC:7701 ! NDUFB6 +relationship: has_part HGNC:7702 ! NDUFB7 +relationship: has_part HGNC:7703 ! NDUFB8 +relationship: has_part HGNC:7704 ! NDUFB9 +relationship: has_part HGNC:7696 ! NDUFB10 +relationship: has_part HGNC:20372 ! NDUFB11 +relationship: has_part HGNC:7705 ! NDUFC1 +relationship: has_part HGNC:7706 ! NDUFC2 +relationship: has_part HGNC:7711 ! NDUFS4 +relationship: has_part HGNC:7712 ! NDUFS5 +relationship: has_part HGNC:7713 ! NDUFS6 +relationship: has_part HGNC:7719 ! NDUFV3 + +[Term] +id: FPLX:000501 name: ETC-complex-I xref: COMPLEXPORTAL:CPX-577 xref: ECCODE:1.6.5.3 @@ -8411,12 +8431,12 @@ xref: GO:0005747 xref: HGNC_GROUP:640 xref: MESH:D042967 xref: NCIT:C118184 -is_a: FPLX:root -has_part: FPLX:ETC_complex_I_core -has_part: FPLX:ETC_complex_I_supernumerary +is_a: FPLX:000000 ! famplex +relationship: has_part FPLX:000499 ! ETC_complex_I_core +relationship: has_part FPLX:000500 ! ETC_complex_I_supernumerary [Term] -id: FPLX:ETC_complex_II +id: FPLX:000502 name: ETC-complex-II synonym: "complex II" EXACT [] synonym: "succinate dehydrogenase (ubiquinone)" EXACT [] @@ -8430,14 +8450,14 @@ xref: MESH:D042963 xref: NCIT:C112049 xref: RE:R-HSA-165631 xref: RE:R-HSA-70990 -is_a: FPLX:root -has_part: HGNC:SDHA -has_part: HGNC:SDHB -has_part: HGNC:SDHC -has_part: HGNC:SDHD +is_a: FPLX:000000 ! famplex +relationship: has_part HGNC:10680 ! SDHA +relationship: has_part HGNC:10681 ! SDHB +relationship: has_part HGNC:10682 ! SDHC +relationship: has_part HGNC:10683 ! SDHD [Term] -id: FPLX:ETC_complex_III +id: FPLX:000503 name: ETC-complex-III synonym: "complex III" EXACT [] synonym: "cytochrome bc1 complex" EXACT [] @@ -8448,57 +8468,53 @@ xref: GO:0005750 xref: GO:0045275 xref: HGNC_GROUP:642 xref: MESH:D014450 -is_a: FPLX:root -has_part: HGNC:CYC1 -has_part: HGNC:MT-CYB -has_part: HGNC:UQCRB -has_part: HGNC:UQCRC1 -has_part: HGNC:UQCRC2 -has_part: HGNC:UQCRFS1 -has_part: HGNC:UQCRH -has_part: HGNC:UQCRQ -has_part: HGNC:UQCR10 -has_part: HGNC:UQCR11 - -[Term] -id: FPLX:ETC_complex_IV +is_a: FPLX:000000 ! famplex +relationship: has_part HGNC:2579 ! CYC1 +relationship: has_part HGNC:7427 ! MT-CYB +relationship: has_part HGNC:12582 ! UQCRB +relationship: has_part HGNC:12585 ! UQCRC1 +relationship: has_part HGNC:12586 ! UQCRC2 +relationship: has_part HGNC:12587 ! UQCRFS1 +relationship: has_part HGNC:12590 ! UQCRH +relationship: has_part HGNC:29594 ! UQCRQ +relationship: has_part HGNC:30863 ! UQCR10 +relationship: has_part HGNC:30862 ! UQCR11 + +[Term] +id: FPLX:000504 name: ETC-complex-IV xref: ECCODE:1.9.3.1 xref: GO:0005751 xref: HGNC_GROUP:643 xref: MESH:D003576 xref: NCIT:C26034 -is_a: FPLX:root -has_part: HGNC:COX4I1 -has_part: HGNC:COX4I2 -has_part: HGNC:COX5A -has_part: HGNC:COX5B -has_part: HGNC:COX6A1 -has_part: HGNC:COX6A2 -has_part: HGNC:COX6B1 -has_part: HGNC:COX6B2 -has_part: HGNC:COX6C -has_part: HGNC:COX7A1 -has_part: HGNC:COX7A2 -has_part: HGNC:COX7B -has_part: HGNC:COX7B2 -has_part: HGNC:COX7C -has_part: HGNC:COX8A -has_part: HGNC:COX8C -has_part: HGNC:MT-CO1 -has_part: HGNC:MT-CO2 -has_part: HGNC:MT-CO3 - -[Term] -id: FPLX:ETC_complex_V +is_a: FPLX:000000 ! famplex +relationship: has_part HGNC:2265 ! COX4I1 +relationship: has_part HGNC:16232 ! COX4I2 +relationship: has_part HGNC:2267 ! COX5A +relationship: has_part HGNC:2269 ! COX5B +relationship: has_part HGNC:2277 ! COX6A1 +relationship: has_part HGNC:2279 ! COX6A2 +relationship: has_part HGNC:2280 ! COX6B1 +relationship: has_part HGNC:24380 ! COX6B2 +relationship: has_part HGNC:2285 ! COX6C +relationship: has_part HGNC:2287 ! COX7A1 +relationship: has_part HGNC:2288 ! COX7A2 +relationship: has_part HGNC:2291 ! COX7B +relationship: has_part HGNC:24381 ! COX7B2 +relationship: has_part HGNC:2292 ! COX7C +relationship: has_part HGNC:2294 ! COX8A +relationship: has_part HGNC:24382 ! COX8C +relationship: has_part HGNC:7419 ! MT-CO1 +relationship: has_part HGNC:7421 ! MT-CO2 +relationship: has_part HGNC:7422 ! MT-CO3 + +[Term] +id: FPLX:000505 name: ETC-complex-V xref: ECCODE:3.6.3.14 xref: GO:0005753 xref: HGNC_GROUP:644 xref: MESH:D025261 -is_a: FPLX:root - -[Term] -id: FPLX:root -name: PROTEIN-FAMILY-OR-COMPLEX +is_a: FPLX:000000 ! famplex diff --git a/export/obo.py b/export/obo.py deleted file mode 100644 index 66f2da58e..000000000 --- a/export/obo.py +++ /dev/null @@ -1,153 +0,0 @@ -import os -import csv -import sys -import datetime -import collections - - -if sys.version_info.major < 3: - raise Exception('This script should be run in Python 3.') - - -Reference = collections.namedtuple('Reference', ['ns', 'id']) -Synonym = collections.namedtuple('Synonym', ['name', 'status']) - - -class OboTerm(object): - def __init__(self, term_id, name, rels, synonyms=None, xrefs=None): - self.term_id = term_id - self.name = name - self.synonyms = synonyms - if xrefs is not None: - self.xrefs = xrefs - else: - self.xrefs = [] - self.rels = rels - - def to_obo(self): - obo_str = '[Term]\n' - obo_str += 'id: %s:%s\n' % (self.term_id.ns, self.term_id.id) - obo_str += 'name: %s\n' % self.name - for synonym in self.synonyms: - obo_str += 'synonym: "%s" %s []\n' % (synonym.name, synonym.status) - for xref in self.xrefs: - if xref.ns == 'BEL': - entry = 'BEL:"%s"' % xref.id - elif xref.ns == 'NXP': - entry = 'NEXTPROT-FAMILY:%s' % xref.id[3:] - elif xref.ns == 'PF': - entry = 'XFAM:%s' % xref.id - elif xref.ns == 'GO': - entry = xref.id - else: - entry = '%s:%s' % (xref.ns, xref.id) - obo_str += 'xref: %s\n' % entry - for rel_type, rel_entries in self.rels.items(): - for ref in rel_entries: - obo_str += '%s: %s:%s\n' % (rel_type, ref.ns, ref.id) - return obo_str - - def __str__(self): - return self.to_obo() - - -def get_obo_terms(): - obo_terms = [] - path_this = os.path.dirname(os.path.abspath(__file__)) - entities_file = os.path.join(path_this, os.pardir, 'entities.csv') - grounding_file = os.path.join(path_this, os.pardir, 'grounding_map.csv') - equiv_file = os.path.join(path_this, os.pardir, 'equivalences.csv') - rel_file = os.path.join(path_this, os.pardir, 'relations.csv') - with open(entities_file, 'r') as fh: - entities = [l.strip() for l in fh.readlines()] - with open(equiv_file, 'r') as fh: - csvreader = csv.reader(fh, delimiter=str(u','), lineterminator='\r\n', - quoting=csv.QUOTE_MINIMAL, - quotechar=str(u'"')) - equivalences = collections.defaultdict(list) - for row in csvreader: - source_ns, source_id, fplx_id = row - equivalences[fplx_id].append((source_ns, source_id)) - with open(grounding_file) as fh: - csvreader = csv.reader(fh, delimiter=str(u','), lineterminator='\r\n', - quoting=csv.QUOTE_MINIMAL, - quotechar=str(u'"')) - textrefs = collections.defaultdict(list) - for row in csvreader: - text_str = row[0] - namespaces = row[1::2] - ids = row[2::2] - for ns, id in zip(namespaces, ids): - if ns == 'FPLX': - textrefs[id].append(text_str) - with open(rel_file) as fh: - rels = {entity: collections.OrderedDict(is_a=[], - part_of=[], - inverse_is_a=[], - has_part=[]) - for entity in entities} - csvreader = csv.reader(fh, delimiter=str(u','), lineterminator='\r\n', - quoting=csv.QUOTE_MINIMAL, - quotechar=str(u'"')) - for row in csvreader: - ns1, id1, rel, ns2, id2 = row - if ns1 == 'FPLX': - if rel == 'isa': - rels[id1]['is_a'].append(Reference(ns2, id2)) - elif rel == 'partof': - rels[id1]['part_of'].append(Reference(ns2, id2)) - if ns2 == 'FPLX': - if rel == 'isa': - rels[id2]['inverse_is_a'].append(Reference(ns1, id1)) - elif rel == 'partof': - rels[id2]['has_part'].append(Reference(ns1, id1)) - - # For each entity in famplex - for entity in entities: - entity_id = Reference('FPLX', entity) - # Construct string name - name = entity.replace('_', '-') - # Get synonyms - refs = textrefs.get(entity) - synonyms = [] - if refs: - for textref in refs: - synonyms.append(Synonym(textref, 'EXACT')) - # Get xrefs - equivs = equivalences.get(entity) - xrefs = [] - if equivs: - for equiv in equivs: - xrefs.append(Reference(equiv[0], equiv[1])) - # If the entity has no isa relations, connect it to the root - if not rels[entity]['is_a'] and not rels[entity]['part_of']: - rels[entity]['is_a'].append(Reference('FPLX', 'root')) - term = OboTerm(entity_id, name, rels[entity], synonyms, xrefs) - obo_terms.append(term) - obo_terms.append(OboTerm(Reference('FPLX', 'root'), - 'PROTEIN-FAMILY-OR-COMPLEX', - {}, [], {})) - return obo_terms - - -def save_obo_terms(obo_terms, output_file=None): - date = datetime.datetime.today() - date_str = date.strftime('%d:%m:%Y %H:%M') - path_this = os.path.dirname(os.path.abspath(__file__)) - if not output_file: - output_file = os.path.join(path_this, os.pardir, 'famplex.obo') - with open(output_file, 'wt') as fh: - fh.write('format-version: 1.2\n') - fh.write('date: %s\n' % date_str) - fh.write('\n') - for term in obo_terms: - obo_str = term.to_obo() - fh.write(obo_str) - fh.write('\n') - - -if __name__ == '__main__': - obo_terms = get_obo_terms() - path_this = os.path.dirname(os.path.abspath(__file__)) - save_obo_terms(obo_terms, os.path.join(path_this, 'famplex.obo')) - diff --git a/export/relations_graph.pdf b/export/relations_graph.pdf new file mode 100644 index 0000000000000000000000000000000000000000..8d630880c9e6d01d3cfa1622e8d3d69fcbcd09a6 GIT binary patch literal 647387 zcmV)bK&ihaP((&8F)lL-CB)_O4?5av(28Y+-a|L}g=dWMv>eJ_>Vma%Ev{3U~p`z1fm$$#tfAkEa0dA}>0G zdC(onqNu4@RPnS~nU$55b!Qh_l4VMwC@Zsm`~JS=(?Vcx1b~Q>Cq(Aep2Y>yCsgD<9@E?B7oa-gC@V~p2 z|Ns4u%guiMdO9Bt%k}24%+2lo^}JiJmz&k<^}OD!7wg?_x!#^$SL^eBY2*9lasSG& z(>a=(-RpX{*&cbQ4edS5{r$2%uvo7Tud6-7#`x7K%}s-+>-R3#G{;-Ep{-}(dw;+D z$K|hBGk@D^$%;(;&|iJwE#q_kIjmo|$K9EC-E3Y@yYqJW<;TTeeEG6wX} zfBoI^|5&|lmM_2kj&@VuSt^J$7sU3e+ z|J}6_zxmbg*WWGw$MVbHE`IZc-^R|p9`_seWaD4w!|Hh2`CF$ynB48f;kbJ}ZjP+{ zhRyD+(>nHgyF6^RubVCVdtNQ~`!mn(H~#(oa(6zwZa5A!b~`88>=%7l>v38ht)DZS z+k86q!Ta5qmA}95-?yOE-=+`iJu&TrTf94MUN;=v<>3@Nyjgttae1-DZOMQC_ifGp 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zkL!Zg=->O|>}X(NZQ_XVCw-JHJVAK?AZ1pvvvURkj{h%9ByCOYNdG%yBt=NINO{;y z42@0MxPk24T*h2%Y^(qPE1Rhit09*Wki*1)g`E%K|E@x+LkdbQCuh(t@>gPk#tE8B M1WHO#c`=0l0?<66H2?qr literal 0 HcmV?d00001 diff --git a/export/relations_graph.py b/export/relations_graph.py deleted file mode 100644 index 2c3797322..000000000 --- a/export/relations_graph.py +++ /dev/null @@ -1,43 +0,0 @@ -from __future__ import print_function, unicode_literals -import os -import csv -import pygraphviz as pgv - - -if __name__ == '__main__': - path_this = os.path.dirname(os.path.abspath(__file__)) - relations_file = os.path.join(path_this, os.pardir, 'relations.csv') - output_file = os.path.join(path_this, os.pardir, 'relations.pdf') - rows = [] - - graph = pgv.AGraph(name='relations', directed=True, rankdir='LR') - hgnc_style = {'color': 'lightgray', 'style': 'filled', - 'fontname': 'arial'} - be_style = {'color': 'pink', 'style': 'filled', - 'fontname': 'arial'} - edge_style = {'fontname': 'arial'} - - with open(relations_file) as f: - csvreader = csv.reader(f, delimiter=str(u','), lineterminator='\r\n', - quoting=csv.QUOTE_MINIMAL, - quotechar=str(u'"')) - nodes = set([]) - isa_edges = set([]) - partof_edges = set([]) - for row in csvreader: - ns1, id1, rel, ns2, id2 = row - def node_label(ns, id): - return '%s:%s' % (ns, id) - for ns, id in ((ns1, id1), (ns2, id2)): - if ns == 'HGNC': - graph.add_node(node_label(ns, id), **hgnc_style) - elif ns == 'FPLX': - graph.add_node(node_label(ns, id), **be_style) - edge = (node_label(ns1, id1), node_label(ns2, id2)) - if rel == 'isa': - graph.add_edge(edge, label='isa', **edge_style) - elif rel == 'partof': - graph.add_edge(edge, label='partof', **edge_style) - - graph.draw(output_file, prog='dot') - diff --git a/famplex/__init__.py b/famplex/__init__.py new file mode 100644 index 000000000..aae4d554e --- /dev/null +++ b/famplex/__init__.py @@ -0,0 +1,3 @@ +# -*- coding: utf-8 -*- + +"""FamPlex Python package.""" diff --git a/famplex/constants.py b/famplex/constants.py new file mode 100644 index 000000000..957ab9e5a --- /dev/null +++ b/famplex/constants.py @@ -0,0 +1,16 @@ +# -*- coding: utf-8 -*- + +"""Constants for the FamPlex Python package.""" + +import os + +HERE = os.path.abspath(os.path.dirname(__file__)) + +RESOURCES = os.path.join(HERE, 'resources') +ENTITIES_TSV_PATH = os.path.join(RESOURCES, 'entities.tsv') +EQUIVALENCES_TSV_PATH = os.path.join(RESOURCES, 'equivalences.tsv') +GROUNDING_MAP_TSV_PATH = os.path.join(RESOURCES, 'grounding_map.tsv') +RELATIONS_TSV_PATH = os.path.join(RESOURCES, 'relations.tsv') +METADATA_PATH = os.path.join(RESOURCES, 'metadata.json') + +EXPORT_DIR = os.path.abspath(os.path.join(HERE, os.pardir, 'export')) diff --git a/famplex/export/__init__.py b/famplex/export/__init__.py new file mode 100644 index 000000000..44ad38158 --- /dev/null +++ b/famplex/export/__init__.py @@ -0,0 +1,3 @@ +# -*- coding: utf-8 -*- + +"""Export scripts for FamPlex.""" diff --git a/famplex/export/__main__.py b/famplex/export/__main__.py new file mode 100644 index 000000000..fec3eea57 --- /dev/null +++ b/famplex/export/__main__.py @@ -0,0 +1,8 @@ +# -*- coding: utf-8 -*- + +"""A command line interface for FamPlex exporters.""" + +from famplex.export.cli import main + +if __name__ == '__main__': + main() diff --git a/famplex/export/cli.py b/famplex/export/cli.py new file mode 100644 index 000000000..4b557b7c8 --- /dev/null +++ b/famplex/export/cli.py @@ -0,0 +1,22 @@ +# -*- coding: utf-8 -*- + +"""A command line interface for FamPlex exporters.""" + +import famplex.export.export_belns +import famplex.export.export_obo +import famplex.export.export_relations_graph + +__all__ = [ + 'main', +] + + +def main() -> None: + """Export FamPlex to all file types.""" + famplex.export.export_belns.main() + famplex.export.export_obo.main() + famplex.export.export_relations_graph.main() + + +if __name__ == '__main__': + main() diff --git a/export/belns.py b/famplex/export/export_belns.py similarity index 67% rename from export/belns.py rename to famplex/export/export_belns.py index 0272f4074..a2aeebcf4 100644 --- a/export/belns.py +++ b/famplex/export/export_belns.py @@ -1,24 +1,26 @@ -#! /usr/bin/env python3 # -*- coding: utf-8 -*- -"""Output FamPlex as a BEL namespace. Requires the `bel_resources` package.""" +"""Output FamPlex as a BEL namespace using the :mod:`bel_resources` package.""" import os from bel_resources import write_namespace from bel_resources.constants import NAMESPACE_DOMAIN_GENE -path_this = os.path.dirname(os.path.abspath(__file__)) -entities_file = os.path.join(path_this, os.pardir, 'entities.csv') -output_file = os.path.join(path_this, 'famplex.belns') +from famplex.constants import ENTITIES_TSV_PATH, EXPORT_DIR + +DEFAULT_BELNS_PATH = os.path.join(EXPORT_DIR, 'famplex.belns') def _get_entities(): - with open(entities_file, 'r') as fh: - return {l.strip(): 'GRPC' for l in fh.readlines()} + with open(ENTITIES_TSV_PATH) as fh: + return { + l.strip().split('\t')[1]: 'GRPC' + for l in fh.readlines() + } -def _write_namespace(values): +def _write_namespace(values, output_file): with open(output_file, 'w') as file: write_namespace( namespace_name='FamPlex', @@ -38,6 +40,10 @@ def _write_namespace(values): ) -if __name__ == '__main__': +def main(output_file=DEFAULT_BELNS_PATH): entities = _get_entities() - _write_namespace(entities) + _write_namespace(entities, output_file) + + +if __name__ == '__main__': + main() diff --git a/famplex/export/export_obo.py b/famplex/export/export_obo.py new file mode 100644 index 000000000..6fc3909db --- /dev/null +++ b/famplex/export/export_obo.py @@ -0,0 +1,227 @@ +import collections +import csv +import datetime +import os + +from famplex.constants import ( + ENTITIES_TSV_PATH, EQUIVALENCES_TSV_PATH, EXPORT_DIR, GROUNDING_MAP_TSV_PATH, RELATIONS_TSV_PATH, +) + +DEFAULT_OBO_PATH = os.path.join(EXPORT_DIR, 'famplex.obo') + +Synonym = collections.namedtuple('Synonym', ['name', 'status']) + + +class Reference: + def __init__(self, db, identifier, name=None): + self.db = db + self.id = identifier + self.name = name + + +ROOT_REFERENCE = Reference('FPLX', '000000', 'famplex') + + +class OboTerm: + def __init__( + self, + *, + term_id, + description=None, + references=None, + rels=None, + synonyms=None, + xrefs=None, + ): + self.term_id = term_id + self.description = description + self.references = references + self.rels = rels or {} + self.synonyms = synonyms or [] + self.xrefs = xrefs or [] + + def to_obo(self): + obo_str = '[Term]\n' + obo_str += 'id: %s:%s\n' % (self.term_id.db, self.term_id.id) + obo_str += 'name: %s\n' % self.term_id.name + if self.description is not None: + obo_str += 'def: "%s" [%s]\n' % (self.description, ','.join(self.references)) + + for synonym in self.synonyms: + obo_str += 'synonym: "%s" %s []\n' % (synonym.name, synonym.status) + + for xref in self.xrefs: + if xref.db == 'BEL': + entry = 'BEL:"%s"' % xref.id + elif xref.db == 'NXP': + entry = 'NEXTPROT-FAMILY:%s' % xref.id[3:] + elif xref.db == 'PF': + entry = 'XFAM:%s' % xref.id + elif xref.db == 'GO': + entry = xref.id + else: + entry = '%s:%s' % (xref.db, xref.id) + + if xref.name is not None: + entry += f' ! {xref.name}' + + obo_str += 'xref: %s\n' % entry + + for rel_type, rel_entries in self.rels.items(): + for ref in rel_entries: + if rel_type == 'is_a': + obo_str += '%s: %s:%s' % (rel_type, ref.db, ref.id) + else: + obo_str += 'relationship: %s %s:%s' % (rel_type, ref.db, ref.id) + if ref.name is not None: + obo_str += f' ! {ref.name}' + obo_str += '\n' + + return obo_str + + def __str__(self): + return self.to_obo() + + +ROOT_OBO_TERM = OboTerm(term_id=ROOT_REFERENCE) + + +def get_obo_terms(): + obo_terms = [ROOT_OBO_TERM] + + with open(ENTITIES_TSV_PATH) as fh: + reader = csv.reader( + fh, + delimiter='\t', + lineterminator='\r\n', + quoting=csv.QUOTE_MINIMAL, + ) + entities = { + fplx_id: ( + fplx_name, + None if description == '.' else description, + None if references == '.' else [r.strip() for r in references.split(',')], + ) + for fplx_id, fplx_name, description, references in reader + } + + with open(EQUIVALENCES_TSV_PATH, 'r') as fh: + reader = csv.reader( + fh, + delimiter='\t', + lineterminator='\r\n', + quoting=csv.QUOTE_MINIMAL, + ) + equivalences = collections.defaultdict(list) + for xref_db, xref_id, fplx_id, _ in reader: + equivalences[fplx_id].append((xref_db, xref_id)) + + with open(GROUNDING_MAP_TSV_PATH) as fh: + reader = csv.reader( + fh, + delimiter='\t', + lineterminator='\r\n', + quoting=csv.QUOTE_MINIMAL, + ) + textrefs = collections.defaultdict(list) + for textref, db, db_id, _ in reader: + if db == 'FPLX': + textrefs[db_id].append(textref) + + with open(RELATIONS_TSV_PATH) as fh: + rels = { + entity: collections.OrderedDict( + is_a=[], + part_of=[], + inverse_is_a=[], + has_part=[], + ) + for entity in entities + } + reader = csv.reader( + fh, + delimiter='\t', + lineterminator='\r\n', + quoting=csv.QUOTE_MINIMAL, + ) + for sub_db, sub_id, sub_name, rel, obj_db, obj_id, obj_name in reader: + if sub_db == 'FPLX': + if rel == 'isa': + rels[sub_id]['is_a'].append(Reference(obj_db, obj_id, obj_name)) + elif rel == 'partof': + rels[sub_id]['part_of'].append(Reference(obj_db, obj_id, obj_name)) + if obj_db == 'FPLX': + if rel == 'isa': + rels[obj_id]['inverse_is_a'].append(Reference(sub_db, sub_id, sub_name)) + elif rel == 'partof': + rels[obj_id]['has_part'].append(Reference(sub_db, sub_id, sub_name)) + + # For each entity in famplex + for fplx_id, (fplx_name, description, references) in entities.items(): + name = fplx_name.replace('_', '-') + + term_id = Reference('FPLX', fplx_id, name) + + synonyms = [ # Get synonyms + Synonym(textref, 'EXACT') + for textref in textrefs.get(fplx_id, []) + ] + + xrefs = [ # Get xrefs + Reference(xref_db, xref_id) + for xref_db, xref_id in equivalences.get(fplx_id, []) + ] + # If the entity has no isa relations, connect it to the root + if not rels[fplx_id]['is_a'] and not rels[fplx_id]['part_of']: + rels[fplx_id]['is_a'].append(ROOT_REFERENCE) + + obo_term = OboTerm( + term_id=term_id, + description=description, + references=references, + rels=rels[fplx_id], + synonyms=synonyms, + xrefs=xrefs, + ) + obo_terms.append(obo_term) + + return obo_terms + + +def save_obo_terms(obo_terms, output_file): + date = datetime.datetime.today() + date_str = date.strftime('%d:%m:%Y %H:%M') + with open(output_file, 'w') as fh: + fh.write('format-version: 1.2\n') + fh.write('date: %s\n' % date_str) + fh.write(""" +[Typedef] +id: part_of +name: part of +namespace: external +xref: BFO:0000050 +is_transitive: true + +[Typedef] +id: inverse_is_a +name: inverse is_a + +[Typedef] +id: has_part +name: has part + +""") + + for term in obo_terms: + obo_str = term.to_obo() + fh.write(obo_str) + fh.write('\n') + + +def main(): + obo_terms = get_obo_terms() + save_obo_terms(obo_terms, DEFAULT_OBO_PATH) + + +if __name__ == '__main__': + main() diff --git a/famplex/export/export_relations_graph.py b/famplex/export/export_relations_graph.py new file mode 100644 index 000000000..26336796b --- /dev/null +++ b/famplex/export/export_relations_graph.py @@ -0,0 +1,48 @@ +import csv +import os + +import pygraphviz as pgv + +from famplex.constants import EXPORT_DIR, RELATIONS_TSV_PATH + +DEFAULT_RELATIONS_GRAPH_PATH = os.path.join(EXPORT_DIR, 'relations_graph.pdf') + +HGNC_STYLE = { + 'color': 'lightgray', + 'style': 'filled', + 'fontname': 'arial', +} +FAMPLEX_STYLE = { + 'color': 'pink', + 'style': 'filled', + 'fontname': 'arial', +} +EDGE_STYLE = { + 'fontname': 'arial', +} + + +def node_label(db, db_id, name): + return '%s:%s ! %s' % (db, db_id, name) + + +def main(output_file=DEFAULT_RELATIONS_GRAPH_PATH): + graph = pgv.AGraph(name='relations', directed=True, rankdir='LR') + + with open(RELATIONS_TSV_PATH) as f: + for ns1, id1, name1, rel, ns2, id2, name2 in csv.reader(f, delimiter='\t'): + sub, obj = node_label(ns1, id1, name1), node_label(ns2, id2, name2) + + for db, label in ((ns1, sub), (ns2, obj)): + if db == 'HGNC': + graph.add_node(label, **HGNC_STYLE) + elif db == 'FPLX': + graph.add_node(label, **FAMPLEX_STYLE) + + graph.add_edge(sub, obj, label=rel, **EDGE_STYLE) + + graph.draw(output_file, prog='dot') + + +if __name__ == '__main__': + main() diff --git a/famplex/reorganize_old_resources.py b/famplex/reorganize_old_resources.py new file mode 100644 index 000000000..d405b3679 --- /dev/null +++ b/famplex/reorganize_old_resources.py @@ -0,0 +1,175 @@ +# -*- coding: utf-8 -*- + +"""This script upgrades all of the FamPlex CSV files.""" + +import csv +import json +import os +import time +from collections import Counter +from operator import itemgetter +from typing import Tuple + +from constants import ( + ENTITIES_TSV_PATH, EQUIVALENCES_TSV_PATH, GROUNDING_MAP_TSV_PATH, METADATA_PATH, + RELATIONS_TSV_PATH, +) +from indra.databases import chebi_client, go_client, hgnc_client, mesh_client, mirbase_client, uniprot_client + +HERE = os.path.abspath(os.path.dirname(__file__)) + +# Input paths +INPUT_RESOURCES = os.path.join(HERE, os.pardir) +ENTITIES_CSV_PATH = os.path.join(INPUT_RESOURCES, 'entities.csv') +EQUIVALENCES_CSV_PATH = os.path.join(INPUT_RESOURCES, 'equivalences.csv') +GROUNDING_MAP_CSV_PATH = os.path.join(INPUT_RESOURCES, 'grounding_map.csv') +RELATIONS_CSV_PATH = os.path.join(INPUT_RESOURCES, 'relations.csv') +DESCRIPTIONS_CSV_PATH = os.path.join(INPUT_RESOURCES, 'descriptions.csv') + +FAMPLEX_DESCRIPTION = 'A protein family, complex, family of complexes,or complex of families' + +client_lookups = [ + ('HGNC', hgnc_client.get_hgnc_id), + ('UP', uniprot_client.get_mnemonic), + ('GO', go_client.get_go_label), + ('MESH', mesh_client.get_mesh_name), + ('MIRBASE', mirbase_client.get_mirbase_name_from_mirbase_id), + ('CHEBI', chebi_client.get_chebi_name_from_id), +] + + +def main(): + fplx_name_to_id = {} + + def get_id_label(db: str, db_id: str) -> Tuple[str, str]: + if db == 'FPLX': + return fplx_name_to_id[db_id], db_id + + for client, lookup in client_lookups: + if db == client: + return lookup(db_id), db_id + + else: + return db_id, '.' + + with open('descriptions.tsv') as in_file: + reader = csv.reader( + in_file, + delimiter='\t', + lineterminator='\r\n', + ) + fplx_name_to_description = { + fplx_name: ( + description, + [r.strip() for r in references.split(',')], + ) + for fplx_name, references, description in reader + } + + with open('entities.csv') as in_file, open(ENTITIES_TSV_PATH, 'w') as out_file: + # print('fplx_id', 'name', 'description', sep='\t', file=out_file) + + # TODO should an explicity entity for famplex be included? + # print('000000', 'famplex', FAMPLEX_DESCRIPTION, sep='\t', file=out_file) + for i, fplx_name in enumerate(in_file, start=1): + fplx_name = fplx_name.strip() + fplx_id = fplx_name_to_id[fplx_name] = f'{i:06}' + description, references = fplx_name_to_description.get(fplx_name, (None, None)) + print( + fplx_id, + fplx_name, + description if description is not None else '.', + ','.join(references) if references is not None else '.', + sep='\t', + file=out_file, + ) + + with open('equivalences.csv') as in_file, open(EQUIVALENCES_TSV_PATH, 'w') as out_file: + # print('xref_db', 'xref_id', 'fplx_id', 'fplx_name', sep='\t', file=out_file) + reader = csv.reader( + in_file, + delimiter=',', + lineterminator='\r\n', + quoting=csv.QUOTE_MINIMAL, + quotechar='"', + ) + for xref_db, xref_name, fplx_name in reader: + print(xref_db, xref_name, fplx_name_to_id[fplx_name], fplx_name, sep='\t', file=out_file) + + grounding_unlabelled = set() + with open('grounding_map.csv') as in_file, open(GROUNDING_MAP_TSV_PATH, 'w') as out_file: + # print('text', 'db', 'identifier', 'name', sep='\t', file=out_file) + + reader = csv.reader( + in_file, + delimiter=',', + lineterminator='\r\n', + quoting=csv.QUOTE_MINIMAL, + quotechar='"', + ) + for text, *line in reader: + for xref_db, identifier in zip(line[::2], line[1::2]): + if not xref_db or not identifier: + continue + + identifier, xref_name = get_id_label(xref_db, identifier) + if xref_name == '.': + grounding_unlabelled.add((xref_db, identifier)) + + print(text, xref_db, identifier, xref_name, sep='\t', file=out_file) + + # Logging for unlabelled entities + print(f'\n{len(grounding_unlabelled)} groundings are unlabelled:') + grounding_unlabelled_counter = Counter(map(itemgetter(0), grounding_unlabelled)) + s = max(map(len, grounding_unlabelled_counter)) + for xref_db, count in grounding_unlabelled_counter.most_common(): + print(f'{xref_db:>{s}s} unlabelled {count}') + + relations_unlabelled = set() + with open('relations.csv') as in_file, open(RELATIONS_TSV_PATH, 'w') as out_file: + # print('sub_db', 'sub_id', 'sub_name', 'rel', + # 'obj_db', 'obj_id', 'obj_name', sep='\t', file=out_file) + + reader = csv.reader( + in_file, + delimiter=',', + lineterminator='\r\n', + quoting=csv.QUOTE_MINIMAL, + quotechar='"', + ) + for sub_db, sub_id, rel, obj_db, obj_id in reader: + sub_id, sub_name = get_id_label(sub_db, sub_id) + if sub_name == '.': + relations_unlabelled.add((sub_db, sub_id)) + + obj_id, obj_name = get_id_label(obj_db, obj_id) + if obj_name == '.': + relations_unlabelled.add((obj_db, obj_id)) + + print(sub_db, sub_id, sub_name, rel, + obj_db, obj_id, obj_name, sep='\t', file=out_file) + + if relations_unlabelled: # Logging for unlabelled entities + print(f'\n{len(relations_unlabelled)} relations are unlabelled:') + relations_unlabelled_counter = Counter(map(itemgetter(0), relations_unlabelled)) + s = max(map(len, relations_unlabelled_counter)) + for xref_db, count in relations_unlabelled_counter.most_common(): + print(f'{xref_db:>{s}s} unlabelled {count}') + + metadata = { + 'Time Exported': str(time.asctime()), + 'Unlabelled Groundings': [ + dict(db=db, db_id=db_id) + for db, db_id in sorted(grounding_unlabelled) + ], + 'Unlabelled Relations': [ + dict(db=db, db_id=db_id) + for db, db_id in sorted(relations_unlabelled) + ] + } + with open(METADATA_PATH, 'w') as file: + json.dump(metadata, file, indent=2, sort_keys=True) + + +if __name__ == '__main__': + main() diff --git a/famplex/resources/entities.tsv b/famplex/resources/entities.tsv new file mode 100644 index 000000000..386631137 --- /dev/null +++ b/famplex/resources/entities.tsv @@ -0,0 +1,505 @@ +000001 9_1_1 . . +000002 A4GALT_family . . +000003 ABL_family . . +000004 ACAD . . +000005 ACC . . +000006 Acetyl_CoA_synthetase . . +000007 ACOX . . +000008 ACSL . . +000009 Actin . . +000010 Activin . . +000011 Activin_A . . +000012 Activin_AB . . +000013 Activin_B . . +000014 ACTN . . +000015 Adaptor_protein_II . . +000016 Adaptor_protein_III . . +000017 ADCY . . +000018 ADH . . +000019 ADRA . . +000020 ADRA2 . . +000021 ADRB . . +000022 ADRBK . . +000023 AKT . . +000024 ALDH . . +000025 ALDO . . +000026 ALG10 . . +000027 ALG1_family . . +000028 ALG3_family . . +000029 ALG6_family . . +000030 ALG13_family . . +000031 AMPK . . +000032 AMPK_A1B1G1 . . +000033 AMPK_A1B1G2 . . +000034 AMPK_A1B1G3 . . +000035 AMPK_A1B2G1 . . +000036 AMPK_A1B2G2 . . +000037 AMPK_A1B2G3 . . +000038 AMPK_A2B1G1 . . +000039 AMPK_A2B1G2 . . +000040 AMPK_A2B1G3 . . +000041 AMPK_A2B2G1 . . +000042 AMPK_A2B2G2 . . +000043 AMPK_A2B2G3 . . +000044 AMPK_alpha . . +000045 AMPK_beta . . +000046 AMPK_gamma . . +000047 Annexin_II_heterotetramer . . +000048 AP1 . . +000049 AP2A . . +000050 APC_C . . +000051 APOA . . +000052 Apolipoprotein . . +000053 ARF_GTPase_family . . +000054 Arp2_3_protein . . +000055 ARRB . . +000056 ATG4 . . +000057 ATP1A . . +000058 ATP1B . . +000059 ATP5G . . +000060 ATP_synthase . . +000061 Augmin . . +000062 AXIN . . +000063 B3GAT . . +000064 BCKDC . . +000065 Beta_3_4_GTF . . +000066 BIRC . . +000067 BMP . . +000068 BMP_receptor . . +000069 BMP_receptor_type_I . . +000070 BMP_receptor_type_II . . +000071 BRCA . . +000072 C1 . . +000073 C1q . . +000074 Cadherin . . +000075 CALM . . +000076 CAMK . . +000077 CAMK2_complex . . +000078 CAMK2_family . . +000079 CAPN . . +000080 Carboxylesterase . . +000081 Caspase . . +000082 Caspase_3_7 . . +000083 CAV . . +000084 CBF3 SKP1 (together with SKP2) was identified as an essential component of the cyclin A-CDK2 S phase kinase complex interpro:IPR016072 +000085 CCT_complex . . +000086 CD16 . . +000087 CD3 . . +000088 CD32 . . +000089 CD64 . . +000090 CD8 . . +000091 CDC25 . . +000092 CDK . . +000093 CDK1_2 . . +000094 CDKN . . +000095 CDKN1 . . +000096 CDKN2 . . +000097 CEBP . . +000098 CHEK . . +000099 Chemokine . . +000100 Chemokine_receptor . . +000101 Cholinesterase . . +000102 CHRM . . +000103 CHRN . . +000104 CK2 . . +000105 Clathrin . . +000106 CNKSR . . +000107 Cofilin . . +000108 Cohesin . . +000109 COL1 . . +000110 COL4 . . +000111 COL5 . . +000112 COLGALT . . +000113 COX . . +000114 COX4 . . +000115 COX6A . . +000116 COX6B . . +000117 COX7A . . +000118 COX7B . . +000119 COX8 . . +000120 CREB . . +000121 CRISP . . +000122 CRSP . . +000123 CRTC . . +000124 CSNK1 . . +000125 CSNK2 . . +000126 CTNNA . . +000127 CUL . . +000128 CXCL_ELR_negative . . +000129 CXCL_ELR_positive . . +000130 Cyclin . . +000131 Cyclin_A . . +000132 Cyclin_D . . +000133 Cyclin_E . . +000134 Cyclophilin . . +000135 Cytoplasmic_dynein . . +000136 DDR . . +000137 Death_receptor . . +000138 Desmoglein . . +000139 DGC . . +000140 DGK . . +000141 DNA_polymerase_delta . . +000142 DNM . . +000143 DRD . . +000144 DUSP . . +000145 DVL . . +000146 DYRK . . +000147 E2F . . +000148 E3_Ub_ligase . . +000149 EDN . . +000150 EGFR_ligand . . +000151 EGR . . +000152 EIF2B . . +000153 EIF4A . . +000154 EIF4EBP . . +000155 EIF4G . . +000156 ELA . . +000157 ENO . . +000158 Ephrin_receptor . . +000159 EPN . . +000160 ERBB . . +000161 ERK . . +000162 ESR . . +000163 ETS . . +000164 EXOC . . +000165 EXT . . +000166 FANC . . +000167 FGF . . +000168 FGFR . . +000169 Fibrinogen . . +000170 FLOT . . +000171 FLRT . . +000172 FNT . . +000173 FOS_family . . +000174 FOXO . . +000175 FSH . . +000176 FUT . . +000177 FZD . . +000178 F_actin . . +000179 GABR . . +000180 GALNT . . +000181 Gamma_secretase . . +000182 GAP . . +000183 GAS6_receptor . . +000184 GATA . . +000185 GCNT . . +000186 GEF . . +000187 GPCR . . +000188 GPIb_IX_V . . +000189 GPIT . . +000190 GPX . . +000191 GRIA . . +000192 GRK . . +000193 GRM . . +000194 GSK3 . . +000195 GST . . +000196 GTF2E . . +000197 GTF2F . . +000198 Glycosyltransferase . . +000199 GTF_family_2 . . +000200 GTF_family_6 . . +000201 GTF_family_8 . . +000202 GTF_family_29 . . +000203 GTF_family_90 . . +000204 GTPase . . +000205 GUCY . . +000206 GYS . . +000207 G_12 . . +000208 G_12_alpha . . +000209 G_alpha . . +000210 G_beta . . +000211 G_gamma . . +000212 G_i . . +000213 G_i_alpha . . +000214 G_protein . . +000215 G_q . . +000216 G_q_alpha . . +000217 G_s . . +000218 G_s_alpha . . +000219 hCG . . +000220 HDAC . . +000221 HDAC_I . . +000222 HDAC_II . . +000223 HDAC_III . . +000224 HDAC_IV . . +000225 HDL . . +000226 Hedgehog . . +000227 Hemoglobin . . +000228 HES . . +000229 HIF . . +000230 HIF1 . . +000231 HIF_alpha . . +000232 HIF_beta . . +000233 Histone . . +000234 Histone_H1 . . +000235 Histone_H2A . . +000236 Histone_H2B . . +000237 Histone_H3 . . +000238 Histone_H4 . . +000239 HLA_DR . . +000240 HMOX . . +000241 HSP90 . . +000242 HSP90A . . +000243 HSP90AA . . +000244 HSPA . . +000245 HSPB . . +000246 IFNA . . +000247 IFNB . . +000248 IGFBP . . +000249 IKB . . +000250 IKK_complex . . +000251 IKK_family . . +000252 IL1 . . +000253 IL12 . . +000254 IL15R . . +000255 IL2R . . +000256 Inhibin . . +000257 Inhibin_A . . +000258 Inhibin_B . . +000259 INS . . +000260 INSR . . +000261 Integrins . . +000262 Interferon . . +000263 Interferon_gamma_receptor . . +000264 IRS . . +000265 IRX . . +000266 JAK . . +000267 JNK . . +000268 JUN_family . . +000269 Kainate_family . . +000270 Kinetochore . . +000271 KLK . . +000272 KSR . . +000273 Laminin_111 . . +000274 Laminin_332 . . +000275 LDH . . +000276 LH . . +000277 LPAR . . +000278 MAC . . +000279 MAF . . +000280 MAP1LC3 . . +000281 MAP2K . . +000282 MAP3K . . +000283 MAPK . . +000284 MCM . . +000285 MEF2 . . +000286 MEK . . +000287 MGAT . . +000288 Mitochondrial_Ribosome . . +000289 MRPS . . +000290 MRPL . . +000291 MMP . . +000292 Metallothionein . . +000293 mTORC1 . . +000294 mTORC2 . . +000295 MYH . . +000296 MYL . . +000297 MYL_alkali . . +000298 MYL_regulatory . . +000299 MYL_slow . . +000300 MYST . . +000301 NADH_dehydrogenase . . +000302 NADPH_oxidase . . +000303 Na_K_ATPase . . +000304 Natriuretic_peptide . . +000305 NCOA . . +000306 NCOR . . +000307 NDRG . . +000308 Neurexins . . +000309 NFAT . . +000310 NFE . . +000311 NFkappaB . . +000312 NFkappaB_1 . . +000313 NFkappaB_2 . . +000314 NFY . . +000315 NKD . . +000316 NOS . . +000317 Notch . . +000318 NRG . . +000319 NRG_1_2 . . +000320 NRG_3_4 . . +000321 NTRK . . +000322 OGT_family . . +000323 p14_3_3 . . +000324 P2RX . . +000325 P2RY . . +000326 p38 . . +000327 p53_family . . +000328 P70S6K . . +000329 P90RSK . . +000330 PAK . . +000331 PARP . . +000332 PARV . . +000333 Patched . . +000334 PBX . . +000335 PDE . . +000336 PDE1 . . +000337 PDE3 . . +000338 PDE4 . . +000339 PDE6 . . +000340 PDE7 . . +000341 PDE8 . . +000342 PDGF . . +000343 PDGFR . . +000344 PDGFR_AA . . +000345 PDGFR_AB . . +000346 PDGFR_BB . . +000347 PDGF_AA . . +000348 PDGF_AB . . +000349 PDGF_BB . . +000350 PDGF_CC . . +000351 PDGF_DD . . +000352 PDH . . +000353 PDK . . +000354 Pertussis_toxin . . +000355 PFN . . +000356 PhK . . +000357 Phosphatase . . +000358 PI3K . . +000359 PI3K_p110 . . +000360 PI3K_p85 . . +000361 PIK3R_I . . +000362 PIM . . +000363 PKA . . +000364 PKC . . +000365 PKI . . +000366 PLA2 . . +000367 PLA2G2 . . +000368 PLA2G4 . . +000369 PLC . . +000370 PLCB . . +000371 PLCD . . +000372 PLCG . . +000373 PLD . . +000374 PPAP2 . . +000375 PPAR . . +000376 PPP1 . . +000377 PPP1C . . +000378 PPP1R . . +000379 PPP2 . . +000380 PPP2C . . +000381 PPP2R_A . . +000382 PPP2R_B . . +000383 PPP3 . . +000384 PPP3C . . +000385 PPP3R . . +000386 PRC1_complex . . +000387 PRC2_complex . . +000388 PRDX . . +000389 PRKAC . . +000390 PRKAR . . +000391 PRKG . . +000392 Propionyl_CoA_carboxylase . . +000393 Protease . . +000394 Proteasome . . +000395 PTGER . . +000396 PYG . . +000397 RAB . . +000398 RAC . . +000399 RAF . . +000400 RAL . . +000401 RAP1 . . +000402 RAPGEF . . +000403 RAR . . +000404 RAS . . +000405 RASA . . +000406 RASAL . . +000407 RasGAP . . +000408 RASGRF . . +000409 RASGRP . . +000410 RASSF . . +000411 RFC . . +000412 RFX . . +000413 RGL . . +000414 RHO . . +000415 RhoGDI . . +000416 RNApo_I . . +000417 RNApo_II . . +000418 ROBO . . +000419 ROCK . . +000420 ROR . . +000421 RPA . . +000422 RSK . . +000423 RTK . . +000424 RXR . . +000425 S100 . . +000426 S100A . . +000427 S1PR . . +000428 SAA . . +000429 SCD . . +000430 SERCA . . +000431 SERPINB . . +000432 SHC . . +000433 SIK . . +000434 SLC2A . . +000435 SLRP . . +000436 SLRP_1 . . +000437 SLRP_2 . . +000438 SLRP_3 . . +000439 SLRP_4 . . +000440 SLRP_5 . . +000441 SMAD . . +000442 SMAD1_5_9 . . +000443 SMAD2_3 . . +000444 SMC1 . . +000445 SMURF . . +000446 SNAI . . +000447 SOD . . +000448 SOS . . +000449 SPRED . . +000450 SPRY . . +000451 SRC . . +000452 SREBF . . +000453 STAT . . +000454 STAT5 . . +000455 STT3 . . +000456 Sulfonylurea_receptor . . +000457 SWI_SNF . . +000458 TAOK . . +000459 TAP . . +000460 TCF_LEF . . +000461 TCR . . +000462 TEAD . . +000463 TFAP2 . . +000464 TFDP . . +000465 TGFB . . +000466 TGFBR . . +000467 THBS . . +000468 THR . . +000469 Thrombin_antithrombin . . +000470 TIAM . . +000471 TIF_IB . . +000472 TLR . . +000473 TN . . +000474 TNF . . +000475 TNFRSF . . +000476 TOP2 . . +000477 Troponin . . +000478 Troponin_C . . +000479 Troponin_I . . +000480 Troponin_T . . +000481 Tryptase . . +000482 TSC . . +000483 TUBA . . +000484 TUBB . . +000485 TUBG . . +000486 Tubulin . . +000487 TXN . . +000488 TXNRD . . +000489 UBE2 . . +000490 Ubiquitin . . +000491 UGCG . . +000492 UGT . . +000493 UGGT . . +000494 VAV . . +000495 VEGF . . +000496 VEGFR . . +000497 Wnt . . +000498 YBX . . +000499 ETC_complex_I_core . . +000500 ETC_complex_I_supernumerary . . +000501 ETC_complex_I . . +000502 ETC_complex_II . . +000503 ETC_complex_III . . +000504 ETC_complex_IV . . +000505 ETC_complex_V . . diff --git a/famplex/resources/equivalences.tsv b/famplex/resources/equivalences.tsv new file mode 100644 index 000000000..173b408db --- /dev/null +++ b/famplex/resources/equivalences.tsv @@ -0,0 +1,1582 @@ +BEL 14-3-3 Family 000323 p14_3_3 +BEL 9-1-1 Complex 000001 9_1_1 +BEL ACAD Family 000004 ACAD +BEL Acetyl CoA Carboxylase Complex 000005 ACC +BEL Acetyl-CoA Synthetase Family 000006 Acetyl_CoA_synthetase +BEL ACOX Family 000007 ACOX +BEL ACSL Family 000008 ACSL +BEL ACT Family 000009 Actin +BEL ACTN Family 000014 ACTN +BEL Adaptor Protein II Complex 000015 Adaptor_protein_II +BEL Adaptor Protein III Complex 000016 Adaptor_protein_III +BEL ADCY Family 000017 ADCY +BEL ADH Family 000018 ADH +BEL ADRA Family 000019 ADRA +BEL ADRA2 Family 000020 ADRA2 +BEL ADRB Family 000021 ADRB +BEL ADRBK Family 000022 ADRBK +BEL AKT Family 000023 AKT +BEL ALDH Family 000024 ALDH +BEL ALDO Family 000025 ALDO +BEL AMP Activated Protein Kinase Complex 000031 AMPK +BEL Annexin II Heterotetramer Complex 000047 Annexin_II_heterotetramer +BEL AP-1 Complex 000048 AP1 +BEL APOA Family 000051 APOA +BEL Arp2/3 Protein Complex 000054 Arp2_3_protein +BEL ARRB Family 000055 ARRB +BEL ATP2A Family 000430 SERCA +BEL ATP5G Family 000059 ATP5G +BEL AXIN Family 000062 AXIN +BEL BIRC Family 000066 BIRC +BEL BMP Family 000067 BMP +BEL BMP Receptor Type I Family 000069 BMP_receptor_type_I +BEL BMP Receptor Type II Family 000070 BMP_receptor_type_II +BEL Branched Chain Alpha Keto Acid Dehydrogenase Complex 000064 BCKDC +BEL C1 Complex 000072 C1 +BEL C1q Complex 000073 C1q +BEL Calcineurin Complex 000383 PPP3 +BEL CALM Family 000075 CALM +BEL CAMK Family 000076 CAMK +BEL CAMK2 Complex 000077 CAMK2_complex +BEL CAMK2 Family 000078 CAMK2_family +BEL CAPN Family 000079 CAPN +BEL Carboxylesterase Family 000080 Carboxylesterase +BEL CASP Family 000081 Caspase +BEL CAV Family 000083 CAV +BEL CBF3 Complex 000084 CBF3 +BEL CCNA Family 000131 Cyclin_A +BEL CCND Family 000132 Cyclin_D +BEL CCNE Family 000133 Cyclin_E +BEL CCT Complex 000085 CCT_complex +BEL CD16 Family 000086 CD16 +BEL CD3 Complex 000087 CD3 +BEL CD32 Family 000088 CD32 +BEL CD64 Family 000089 CD64 +BEL CDC25 Family 000091 CDC25 +BEL CDH Family 000074 Cadherin +BEL CEBP Family 000097 CEBP +BEL Chemokine Receptor Family 000100 Chemokine_receptor +BEL Cholinesterase Family 000101 Cholinesterase +BEL CHRM Family 000102 CHRM +BEL CHRN Complex 000103 CHRN +BEL CK II Complex 000104 CK2 +BEL Clathrin Complex 000105 Clathrin +BEL Cohesin Complex 000108 Cohesin +BEL COL1 Family 000109 COL1 +BEL COL4 Family 000110 COL4 +BEL COL5 Family 000111 COL5 +BEL COX4 Family 000114 COX4 +BEL COX6A Family 000115 COX6A +BEL COX6B Family 000116 COX6B +BEL COX7A Family 000117 COX7A +BEL COX7B Family 000118 COX7B +BEL COX8 Family 000119 COX8 +BEL CREB Family 000120 CREB +BEL CRISP Family 000121 CRISP +BEL CRSP Complex 000122 CRSP +BEL CSNK1 Family 000124 CSNK1 +BEL CSNK2 Family 000125 CSNK2 +BEL CTNNA Family 000126 CTNNA +BEL Cu-Zn SOD Family 000447 SOD +BEL CUL Family 000127 CUL +BEL CXCL ELR-Negative Family 000128 CXCL_ELR_negative +BEL CXCL ELR-Positive Family 000129 CXCL_ELR_positive +BEL Cyclophilin Family 000134 Cyclophilin +BEL Cytochrome C Oxidase Complex Muscle 000113 COX +BEL Cytochrome C Oxidase Complex Non Muscle 000113 COX +BEL Cytoplasmic Dynein Complex 000135 Cytoplasmic_dynein +BEL DDR Family 000136 DDR +BEL Desmoglein Family 000138 Desmoglein +BEL DGK Family 000140 DGK +BEL DNA Polymerase delta Complex 000141 DNA_polymerase_delta +BEL DNM Family 000142 DNM +BEL DRD Family 000143 DRD +BEL DVL Family 000145 DVL +BEL Dystrophin Associated Glycoprotein Complex 000139 DGC +BEL E2F Family 000147 E2F +BEL EDN Family 000149 EDN +BEL EGFR Ligand Family 000150 EGFR_ligand +BEL EGFR/ERBB Family 000160 ERBB +BEL EGR Family 000151 EGR +BEL EIF2B Complex 000152 EIF2B +BEL EIF4A Family 000153 EIF4A +BEL EIF4EBP Family 000154 EIF4EBP +BEL ELA Family 000156 ELA +BEL ENO Family 000157 ENO +BEL Ephrin Receptor Family 000158 Ephrin_receptor +BEL EPN Family 000159 EPN +BEL ESR Family 000162 ESR +BEL ETS Family 000163 ETS +BEL FGF Family 000167 FGF +BEL FGFR Family 000168 FGFR +BEL Fibrinogen Complex 000169 Fibrinogen +BEL FLOT Family 000170 FLOT +BEL FLRT Family 000171 FLRT +BEL Follicle Stimulating Hormone Complex 000175 FSH +BEL FOXO Family 000174 FOXO +BEL FZD Family 000177 FZD +BEL GABR Family 000179 GABR +BEL gamma Secretase Complex 000181 Gamma_secretase +BEL GAS6 Receptor Family 000183 GAS6_receptor +BEL GATA Family 000184 GATA +BEL GNA Gq Family 000215 G_q +BEL GNA Gs Family 000217 G_s +BEL GNAI Family 000212 G_i +BEL GNB Family 000210 G_beta +BEL GNG Family 000211 G_gamma +BEL GPIT Complex 000189 GPIT +BEL GPX Family 000190 GPX +BEL GRIA Family 000191 GRIA +BEL GRK Family 000192 GRK +BEL GRM Family 000193 GRM +BEL GSK3 Family 000194 GSK3 +BEL GST Family 000195 GST +BEL GTF2E Complex 000196 GTF2E +BEL GTF2F Complex 000197 GTF2F +BEL GUCY Family 000205 GUCY +BEL GYS Family 000206 GYS +BEL HDAC Class I Family 000221 HDAC_I +BEL HDAC Class II Family 000222 HDAC_II +BEL HDAC Family 000220 HDAC +BEL HDL Complex 000225 HDL +BEL Hedgehog Family 000226 Hedgehog +BEL Hemoglobin Complex 000227 Hemoglobin +BEL HES Family 000228 HES +BEL Histone Family 000233 Histone +BEL Histone H1 Family 000234 Histone_H1 +BEL Histone H2A Family 000235 Histone_H2A +BEL Histone H2B Family 000236 Histone_H2B +BEL Histone H3 Family 000237 Histone_H3 +BEL Histone H4 Family 000238 Histone_H4 +BEL HLA-DR Family 000239 HLA_DR +BEL HMOX Family 000240 HMOX +BEL HSP90 Family 000241 HSP90 +BEL HSPA Family 000244 HSPA +BEL HSPB Family 000245 HSPB +BEL Ib-V-IX Complex 000188 GPIb_IX_V +BEL IFNA Family 000246 IFNA +BEL IGFBP Family 000248 IGFBP +BEL IkappaB Kinase Complex 000250 IKK_complex +BEL IkappaB Kinase Family 000251 IKK_family +BEL IL1 Family 000252 IL1 +BEL INS Family 000259 INS +BEL INSR Family 000260 INSR +BEL Interferon Gamma Receptor Complex 000263 Interferon_gamma_receptor +BEL IRS Family 000264 IRS +BEL IRX Family 000265 IRX +BEL JAK Family 000266 JAK +BEL Kinetochore Complex 000270 Kinetochore +BEL KLK Family 000271 KLK +BEL Laminin 1 Complex 000273 Laminin_111 +BEL Laminin 5 Complex 000274 Laminin_332 +BEL LDH Family 000275 LDH +BEL Luteinizing Hormone Complex 000276 LH +BEL MAF Family 000279 MAF +BEL MAPK Erk1/2 Family 000161 ERK +BEL MAPK Erk1/3 Family 000161 ERK +BEL MAPK JNK Family 000267 JNK +BEL MAPK p38 Family 000326 p38 +BEL MEF2 Family 000285 MEF2 +BEL MEK1/2 Family 000286 MEK +BEL Membrane Attack Complex 000278 MAC +BEL MMP Family 000291 MMP +BEL MYH Family 000295 MYH +BEL MYL Alkali Family 000297 MYL_alkali +BEL MYL Family 000296 MYL +BEL MYL Regulatory Family 000298 MYL_regulatory +BEL MYL Slow Family 000299 MYL_slow +BEL MYST Family 000300 MYST +BEL Na/K Exchanging ATPase Complex 000303 Na_K_ATPase +BEL NADH Dehydrogenase Complex 000301 NADH_dehydrogenase +BEL NADPH Oxidase Complex 000302 NADPH_oxidase +BEL NCOR Family 000306 NCOR +BEL NDRG Family 000307 NDRG +BEL NFAT Family 000309 NFAT +BEL Nfkb Complex 000311 NFkappaB +BEL Nfy Complex 000314 NFY +BEL NKD Family 000315 NKD +BEL NOS Family 000316 NOS +BEL NOTCH Family 000317 Notch +BEL NRG1/2 Family 000319 NRG_1_2 +BEL NRG3/4 Family 000320 NRG_3_4 +BEL NTRK Family 000321 NTRK +BEL p160/SRC Family 000305 NCOA +BEL P2RX Family 000324 P2RX +BEL P2RY Family 000325 P2RY +BEL p85/p110 PI3Kinase Complex 000358 PI3K +BEL PAK Family 000330 PAK +BEL PARV Family 000332 PARV +BEL PBX Family 000334 PBX +BEL PDE Family 000335 PDE +BEL PDE1 Family 000336 PDE1 +BEL PDE3 Family 000337 PDE3 +BEL PDE4 Family 000338 PDE4 +BEL PDE6 Family 000339 PDE6 +BEL PDGF Family 000342 PDGF +BEL PDGFR Family 000343 PDGFR +BEL PDK Family 000353 PDK +BEL PFN Family 000355 PFN +BEL Phosphorylase B Kinase Complex 000356 PhK +BEL PIK3C Class IA Family 000359 PI3K_p110 +BEL PIK3R Class IA Family 000361 PIK3R_I +BEL PKI Family 000365 PKI +BEL PLA2 Family 000366 PLA2 +BEL PLA2G2 Family 000367 PLA2G2 +BEL PLC Family 000369 PLC +BEL PLCB Family 000370 PLCB +BEL PLCG Family 000372 PLCG +BEL PLD Family 000373 PLD +BEL PPAP2 Family 000374 PPAP2 +BEL PPAR Family 000375 PPAR +BEL PPP1C Family 000377 PPP1C +BEL PPP1R Family 000378 PPP1R +BEL PPP2C Family 000380 PPP2C +BEL PPP2R Subunit A Family 000381 PPP2R_A +BEL PPP2R Subunit B Family 000382 PPP2R_B +BEL PPP3 Family 000383 PPP3 +BEL PPP3C Family 000384 PPP3C +BEL PPP3R Family 000385 PPP3R +BEL PRC1 Maintenance Complex 000386 PRC1_complex +BEL PRC2 Initiation Complex 000387 PRC2_complex +BEL PRDX Family 000388 PRDX +BEL PRKA Family 000389 PRKAC +BEL PRKAA Family 000044 AMPK_alpha +BEL PRKAB Family 000045 AMPK_beta +BEL PRKAG Family 000046 AMPK_gamma +BEL PRKAR Family 000390 PRKAR +BEL PRKC Family 000364 PKC +BEL PRKG Family 000391 PRKG +BEL Propionyl CoA Carboxylase Complex 000392 Propionyl_CoA_carboxylase +BEL Proteasome Complex 000394 Proteasome +BEL Proton Transporting ATP Synthase Complex 000060 ATP_synthase +BEL PTGER Family 000395 PTGER +BEL Pyruvate Dehydrogenase Complex 000352 PDH +BEL RAB Family 000397 RAB +BEL RAC Family 000398 RAC +BEL RAF Family 000399 RAF +BEL RAR Family 000403 RAR +BEL RAS Family 000404 RAS +BEL Respiratory Chain Complex II 000502 ETC_complex_II +BEL Respiratory Chain Complex III 000503 ETC_complex_III +BEL RFC Complex 000411 RFC +BEL RFX Family 000412 RFX +BEL RHO Family 000414 RHO +BEL RNApo I Complex 000416 RNApo_I +BEL RNApo II Complex 000417 RNApo_II +BEL ROCK Family 000419 ROCK +BEL ROR Family 000420 ROR +BEL RPS6KA Family 000329 P90RSK +BEL RPS6KB Family 000328 P70S6K +BEL RXR Family 000424 RXR +BEL S100A Family 000426 S100A +BEL S1PR Family 000427 S1PR +BEL SAA Family 000428 SAA +BEL SCD Family 000429 SCD +BEL SERPINB Family 000431 SERPINB +BEL SLC2A Family 000434 SLC2A +BEL SMAD Family 000441 SMAD +BEL SMC1 Family 000444 SMC1 +BEL SNAI Family 000446 SNAI +BEL SOS Family 000448 SOS +BEL SRC Family 000451 SRC +BEL SREBF Family 000452 SREBF +BEL STAT Family 000453 STAT +BEL STAT5 Family 000454 STAT5 +BEL Sulfonylurea Receptor Family 000456 Sulfonylurea_receptor +BEL SWI/SNF Complex 000457 SWI_SNF +BEL TAP Family 000459 TAP +BEL TCF/LEF Family 000460 TCF_LEF +BEL TFAP2 Family 000463 TFAP2 +BEL TFDP Family 000464 TFDP +BEL TGFB Family 000465 TGFB +BEL THBS Family 000467 THBS +BEL THR Family 000468 THR +BEL Thrombin Antithrombin Complex 000469 Thrombin_antithrombin +BEL TIF IB Complex 000471 TIF_IB +BEL TN Family 000473 TN +BEL TNFRSF Family 000475 TNFRSF +BEL TOP2 Family 000476 TOP2 +BEL TORC2 Complex 000294 mTORC2 +BEL Tryptase Family 000481 Tryptase +BEL TUBA Family 000483 TUBA +BEL TUBB Family 000484 TUBB +BEL TXN Family 000487 TXN +BEL TXNRD Family 000488 TXNRD +BEL UBE2 Family 000489 UBE2 +BEL VAV Family 000494 VAV +BEL VEGF Family 000495 VEGF +BEL VEGFR Family 000496 VEGFR +BEL WNT Family 000497 Wnt +COMPLEXPORTAL CPX-560 000503 ETC_complex_III +COMPLEXPORTAL CPX-561 000502 ETC_complex_II +COMPLEXPORTAL CPX-577 000501 ETC_complex_I +ECCODE 1.1.1.1 000018 ADH +ECCODE 1.10.2.2 000503 ETC_complex_III +ECCODE 1.11.1.15 000388 PRDX +ECCODE 1.11.1.9 000190 GPX +ECCODE 1.14.19.1 000429 SCD +ECCODE 1.14.99.3 000240 HMOX +ECCODE 1.2.1.3 000024 ALDH +ECCODE 1.2.4.1 000353 PDK +ECCODE 1.3.5.1 000502 ETC_complex_II +ECCODE 1.3.8.7 000004 ACAD +ECCODE 1.6.5.3 000501 ETC_complex_I +ECCODE 1.6.5.3 000301 NADH_dehydrogenase +ECCODE 1.9.3.1 000113 COX +ECCODE 1.9.3.1 000504 ETC_complex_IV +ECCODE 2.3.2.23 000489 UBE2 +ECCODE 2.5.1.58 000172 FNT +ECCODE 2.7.1.107 000140 DGK +ECCODE 2.7.11.11 000363 PKA +ECCODE 2.7.11.12 000391 PRKG +ECCODE 2.7.11.13 000364 PKC +ECCODE 2.7.11.16 000192 GRK +ECCODE 2.7.11.17 000076 CAMK +ECCODE 2.7.11.19 000356 PhK +ECCODE 2.7.11.22 000092 CDK +ECCODE 2.7.11.24 000283 MAPK +ECCODE 2.7.11.25 000282 MAP3K +ECCODE 2.7.11.31 000031 AMPK +ECCODE 2.7.12.2 000283 MAPK +ECCODE 3.1.1.1 000080 Carboxylesterase +ECCODE 3.1.1.4 000366 PLA2 +ECCODE 3.1.4.- 000335 PDE +ECCODE 3.1.4.4 000373 PLD +ECCODE 3.4.21.35 000271 KLK +ECCODE 3.4.21.59 000481 Tryptase +ECCODE 3.4.25.1 000394 Proteasome +ECCODE 3.5.1.98 000220 HDAC +ECCODE 3.6.3.14 000505 ETC_complex_V +ECCODE 3.6.3.9 000303 Na_K_ATPase +ECCODE 3.6.5.- 000204 GTPase +ECCODE 4.1.2.13 000025 ALDO +ECCODE 4.6.1.2 000205 GUCY +ECCODE 6.4.1.2 000005 ACC +ECCODE 6.4.1.3 000392 Propionyl_CoA_carboxylase +GFAM 1199 000269 Kainate_family +GFAM 1582 000308 Neurexins +GO GO:0000145 000164 EXOC +GO GO:0000502 000394 Proteasome +GO GO:0000776 000270 Kinetochore +GO GO:0000930 000485 TUBG +GO GO:0004117 000336 PDE1 +GO GO:0004198 000079 CAPN +GO GO:0004199 000081 Caspase +GO GO:0004886 000424 RXR +GO GO:0004890 000179 GABR +GO GO:0004931 000324 P2RX +GO GO:0004936 000019 ADRA +GO GO:0004937 000019 ADRA +GO GO:0004938 000020 ADRA2 +GO GO:0004952 000143 DRD +GO GO:0005007 000168 FGFR +GO GO:0005035 000137 Death_receptor +GO GO:0005094 000415 RhoGDI +GO GO:0005096 000182 GAP +GO GO:0005154 000150 EGFR_ligand +GO GO:0005161 000342 PDGF +GO GO:0005162 000167 FGF +GO GO:0005172 000496 VEGFR +GO GO:0005355 000434 SLC2A +GO GO:0005577 000169 Fibrinogen +GO GO:0005579 000278 MAC +GO GO:0005584 000109 COL1 +GO GO:0005587 000110 COL4 +GO GO:0005588 000111 COL5 +GO GO:0005610 000274 Laminin_332 +GO GO:0005663 000411 RFC +GO GO:0005665 000417 RNApo_II +GO GO:0005673 000196 GTF2E +GO GO:0005674 000197 GTF2F +GO GO:0005680 000050 APC_C +GO GO:0005736 000416 RNApo_I +GO GO:0005747 000501 ETC_complex_I +GO GO:0005749 000502 ETC_complex_II +GO GO:0005750 000503 ETC_complex_III +GO GO:0005751 000504 ETC_complex_IV +GO GO:0005753 000505 ETC_complex_V +GO GO:0005761 000288 Mitochondrial_Ribosome +GO GO:0005762 000290 MRPL +GO GO:0005763 000289 MRPS +GO GO:0005832 000085 CCT_complex +GO GO:0005861 000477 Troponin +GO GO:0005868 000135 Cytoplasmic_dynein +GO GO:0005884 000009 Actin +GO GO:0005956 000104 CK2 +GO GO:0008190 000154 EIF4EBP +GO GO:0008278 000108 Cohesin +GO GO:0008279 000108 Cohesin +GO GO:0008281 000456 Sulfonylurea_receptor +GO GO:0008433 000186 GEF +GO GO:0008599 000376 PPP1 +GO GO:0016010 000139 DGC +GO GO:0016190 000105 Clathrin +GO GO:0016904 000103 CHRN +GO GO:0016914 000175 FSH +GO GO:0019787 000489 UBE2 +GO GO:0030122 000015 Adaptor_protein_II +GO GO:0031518 000084 CBF3 +GO GO:0031931 000293 mTORC1 +GO GO:0031941 000178 F_actin +GO GO:0032281 000191 GRIA +GO GO:0034364 000225 HDL +GO GO:0034666 000261 Integrins +GO GO:0034683 000261 Integrins +GO GO:0034687 000261 Integrins +GO GO:0035098 000387 PRC2_complex +GO GO:0035102 000386 PRC1_complex +GO GO:0038036 000427 S1PR +GO GO:0042555 000284 MCM +GO GO:0042825 000459 TAP +GO GO:0043509 000011 Activin_A +GO GO:0043511 000256 Inhibin +GO GO:0043625 000141 DNA_polymerase_delta +GO GO:0045275 000503 ETC_complex_III +GO GO:0048180 000010 Activin +GO GO:0070652 000061 Augmin +GO GO:0070765 000181 Gamma_secretase +GO GO:1990779 000188 GPIb_IX_V +HGNC_GROUP 1149 000499 ETC_complex_I_core +HGNC_GROUP 1150 000500 ETC_complex_I_supernumerary +HGNC_GROUP 581 000061 Augmin +HGNC_GROUP 640 000501 ETC_complex_I +HGNC_GROUP 641 000502 ETC_complex_II +HGNC_GROUP 642 000503 ETC_complex_III +HGNC_GROUP 643 000504 ETC_complex_IV +HGNC_GROUP 644 000505 ETC_complex_V +IP IPR000074 000052 Apolipoprotein +IP IPR000096 000428 SAA +IP IPR000162 000193 GRM +IP IPR000164 000237 Histone_H3 +IP IPR000239 000192 GRK +IP IPR000308 000323 p14_3_3 +IP IPR000320 000226 Hedgehog +IP IPR000381 000013 Activin_B +IP IPR000388 000456 Sulfonylurea_receptor +IP IPR000406 000415 RhoGDI +IP IPR000451 000311 NFkappaB +IP IPR000454 000059 ATP5G +IP IPR000469 000207 G_12 +IP IPR000469 000208 G_12_alpha +IP IPR000491 000011 Activin_A +IP IPR000654 000215 G_q +IP IPR000654 000216 G_q_alpha +IP IPR000741 000025 ALDO +IP IPR000751 000091 CDC25 +IP IPR000756 000140 DGK +IP IPR000889 000190 GPX +IP IPR000929 000143 DRD +IP IPR000941 000157 ENO +IP IPR000995 000102 CHRM +IP IPR000997 000101 Cholinesterase +IP IPR001090 000158 Ephrin_receptor +IP IPR001132 000441 SMAD +IP IPR001154 000476 TOP2 +IP IPR001208 000284 MCM +IP IPR001217 000453 STAT +IP IPR001241 000476 TOP2 +IP IPR001349 000115 COX6A +IP IPR001370 000066 BIRC +IP IPR001408 000212 G_i +IP IPR001408 000213 G_i_alpha +IP IPR001426 000158 Ephrin_receptor +IP IPR001429 000324 P2RX +IP IPR001442 000110 COL4 +IP IPR001522 000429 SCD +IP IPR001612 000083 CAV +IP IPR001657 000226 Hedgehog +IP IPR001767 000226 Hedgehog +IP IPR001770 000211 G_gamma +IP IPR001928 000149 EDN +IP IPR001951 000238 Histone_H4 +IP IPR002051 000240 HMOX +IP IPR002112 000268 JUN_family +IP IPR002117 000327 p53_family +IP IPR002138 000081 Caspase +IP IPR002194 000085 CCT_complex +IP IPR002205 000476 TOP2 +IP IPR002209 000167 FGF +IP IPR002374 000391 PRKG +IP IPR002453 000484 TUBB +IP IPR002454 000485 TUBG +IP IPR002655 000007 ACOX +IP IPR002717 000300 MYST +IP IPR003000 000223 HDAC_III +IP IPR003074 000375 PPAR +IP IPR003084 000220 HDAC +IP IPR003084 000221 HDAC_I +IP IPR003113 000359 PI3K_p110 +IP IPR003175 000095 CDKN1 +IP IPR003205 000119 COX8 +IP IPR003367 000467 THBS +IP IPR003502 000252 IL1 +IP IPR003586 000226 Hedgehog +IP IPR003587 000226 Hedgehog +IP IPR004000 000009 Actin +IP IPR004030 000316 NOS +IP IPR004061 000427 S1PR +IP IPR004142 000307 NDRG +IP IPR004171 000365 PKI +IP IPR004203 000114 COX4 +IP IPR004241 000280 MAP1LC3 +IP IPR004766 000333 Patched +IP IPR004826 000279 MAF +IP IPR004979 000463 TFAP2 +IP IPR005455 000355 PFN +IP IPR005542 000334 PBX +IP IPR005643 000268 JUN_family +IP IPR005782 000430 SERCA +IP IPR005817 000497 Wnt +IP IPR006019 000432 SHC +IP IPR006338 000488 TXNRD +IP IPR006828 000045 AMPK_beta +IP IPR008297 000317 Notch +IP IPR008349 000161 ERK +IP IPR008351 000267 JNK +IP IPR008352 000326 p38 +IP IPR008366 000309 NFAT +IP IPR008433 000118 COX7B +IP IPR008606 000154 EIF4EBP +IP IPR008631 000206 GYS +IP IPR008859 000467 THBS +IP IPR009045 000226 Hedgehog +IP IPR009123 000138 Desmoglein +IP IPR010011 000305 NCOA +IP IPR010660 000317 Notch +IP IPR010991 000327 p53_family +IP IPR011039 000197 GTF2F +IP IPR011615 000327 p53_family +IP IPR011656 000317 Notch +IP IPR012144 000316 NOS +IP IPR012198 000390 PRKAR +IP IPR012233 000364 PKC +IP IPR012290 000169 Fibrinogen +IP IPR012345 000453 STAT +IP IPR012542 000476 TOP2 +IP IPR013019 000441 SMAD +IP IPR013288 000114 COX4 +IP IPR013506 000476 TOP2 +IP IPR013537 000005 ACC +IP IPR013543 000077 CAMK2_complex +IP IPR013543 000078 CAMK2_family +IP IPR013558 000460 TCF_LEF +IP IPR013706 000336 PDE1 +IP IPR013757 000476 TOP2 +IP IPR013758 000476 TOP2 +IP IPR013759 000476 TOP2 +IP IPR013760 000476 TOP2 +IP IPR013790 000441 SMAD +IP IPR013799 000453 STAT +IP IPR013800 000453 STAT +IP IPR013801 000453 STAT +IP IPR013854 000463 TFAP2 +IP IPR013871 000121 CRISP +IP IPR014788 000101 Cholinesterase +IP IPR014920 000305 NCOA +IP IPR014935 000305 NCOA +IP IPR014936 000062 AXIN +IP IPR015008 000419 ROCK +IP IPR015015 000003 ABL_family +IP IPR015451 000132 Cyclin_D +IP IPR015583 000349 PDGF_BB +IP IPR015588 000247 IFNB +IP IPR015615 000465 TGFB +IP IPR015633 000147 E2F +IP IPR015679 000373 PLD +IP IPR015876 000429 SCD +IP IPR015988 000453 STAT +IP IPR016053 000240 HMOX +IP IPR016072 000084 CBF3 +IP IPR016084 000240 HMOX +IP IPR016239 000329 P90RSK +IP IPR016245 000160 ERBB +IP IPR016246 000260 INSR +IP IPR016247 000420 ROR +IP IPR016248 000168 FGFR +IP IPR016251 000266 JAK +IP IPR016257 000158 Ephrin_receptor +IP IPR016279 000372 PLCG +IP IPR016280 000370 PLCB +IP IPR016311 000163 ETS +IP IPR016319 000465 TGFB +IP IPR016346 000210 G_beta +IP IPR016897 000084 CBF3 +IP IPR017104 000049 AP2A +IP IPR017348 000362 PIM +IP IPR017426 000305 NCOA +IP IPR017897 000467 THBS +IP IPR017904 000107 Cofilin +IP IPR018161 000497 Wnt +IP IPR018207 000240 HMOX +IP IPR018361 000083 CAV +IP IPR018507 000115 COX6A +IP IPR018522 000476 TOP2 +IP IPR019764 000149 EDN +IP IPR020475 000149 EDN +IP IPR020537 000059 ATP5G +IP IPR020684 000419 ROCK +IP IPR020777 000321 NTRK +IP IPR020810 000157 ENO +IP IPR020811 000157 ENO +IP IPR022684 000079 CAPN +IP IPR023272 000118 COX7B +IP IPR023337 000449 SPRED +IP IPR023409 000323 p14_3_3 +IP IPR023410 000323 p14_3_3 +IP IPR024940 000460 TCF_LEF +IP IPR024946 000476 TOP2 +IP IPR025561 000272 KSR +IP IPR026590 000223 HDAC_III +IP IPR027288 000346 PDGFR_BB +IP IPR027290 000344 PDGFR_AA +IP IPR027309 000324 P2RX +IP IPR027705 000170 FLOT +IP IPR027707 000480 Troponin_T +IP IPR027936 000158 Ephrin_receptor +IP IPR028412 000400 RAL +IP IPR028433 000332 PARV +IP IPR028858 000133 Cyclin_E +IP IPR028974 000467 THBS +IP IPR028992 000226 Hedgehog +IP IPR029760 000190 GPX +IP IPR029768 000025 ALDO +IP IPR030492 000311 NFkappaB +IP IPR031327 000284 MCM +IP IPR031635 000321 NTRK +IP IPR031660 000476 TOP2 +IP IPR031675 000377 PPP1C +IP IPR031905 000170 FLOT +IP IPR032067 000174 FOXO +IP IPR032101 000062 AXIN +IP IPR032270 000044 AMPK_alpha +IP IPR032640 000045 AMPK_beta +IP IPR033139 000081 Caspase +IP IPR033614 000410 RASSF +IP IPR033896 000285 MEF2 +IP IPR033923 000330 PAK +IP IPR033926 000311 NFkappaB +IP IPR034117 000121 CRISP +IP IPR034157 000476 TOP2 +IP IPR035014 000391 PRKG +IP IPR035023 000372 PLCG +IP IPR035024 000372 PLCG +MEDSCAN urn:agi-aopfc:0000094 000120 CREB +MEDSCAN urn:agi-aopfc:0000099 000147 E2F +MEDSCAN urn:agi-aopfc:0000105 000184 GATA +MEDSCAN urn:agi-aopfc:0000142 000279 MAF +MEDSCAN urn:agi-aopfc:0000143 000285 MEF2 +MEDSCAN urn:agi-aopfc:0000150 000310 NFE +MEDSCAN urn:agi-aopfc:0000156 000311 NFkappaB +MEDSCAN urn:agi-aopfc:0000157 000412 RFX +MEDSCAN urn:agi-aopfc:0000159 000441 SMAD +MEDSCAN urn:agi-aopfc:0000163 000453 STAT +MEDSCAN urn:agi-aopfc:0000197 000177 FZD +MEDSCAN urn:agi-aopfc:0000252 000136 DDR +MEDSCAN urn:agi-aopfc:0000264 000260 INSR +MEDSCAN urn:agi-aopfc:0000278 000321 NTRK +MEDSCAN urn:agi-aopfc:0000279 000317 Notch +MEDSCAN urn:agi-aopfc:0000281 000333 Patched +MEDSCAN urn:agi-aopfc:0000286 000420 ROR +MEDSCAN urn:agi-aopfc:0000294 000466 TGFBR +MEDSCAN urn:agi-aopfc:0000295 000475 TNFRSF +MEDSCAN urn:agi-aopfc:0000296 000472 TLR +MEDSCAN urn:agi-aopfc:0000311 000187 GPCR +MEDSCAN urn:agi-aopfc:0000391 000099 Chemokine +MEDSCAN urn:agi-aopfc:0000423 000465 TGFB +MEDSCAN urn:agi-aopfc:0000426 000497 Wnt +MEDSCAN urn:agi-aopfc:0000434 000194 GSK3 +MEDSCAN urn:agi-aopfc:0000439 000023 AKT +MEDSCAN urn:agi-aopfc:0000447 000358 PI3K +MEDSCAN urn:agi-aopfc:0000452 000075 CALM +MEDSCAN urn:agi-aopfc:0000455 000366 PLA2 +MEDSCAN urn:agi-aopfc:0000458 000161 ERK +MEDSCAN urn:agi-aopfc:0000462 000286 MEK +MEDSCAN urn:agi-aopfc:0000464 000266 JAK +MEDSCAN urn:agi-aopfc:0000465 000404 RAS +MEDSCAN urn:agi-aopfc:0000468 000330 PAK +MEDSCAN urn:agi-aopfc:0000473 000267 JNK +MEDSCAN urn:agi-aopfc:0000477 000326 p38 +MEDSCAN urn:agi-aopfc:0000479 000302 NADPH_oxidase +MEDSCAN urn:agi-aopfc:0000494 000316 NOS +MEDSCAN urn:agi-aopfc:0000499 000414 RHO +MEDSCAN urn:agi-aopfc:0000504 000494 VAV +MEDSCAN urn:agi-aopfc:0000509 000451 SRC +MEDSCAN urn:agi-aopfc:0000551 000091 CDC25 +MEDSCAN urn:agi-aopfc:0000567 000003 ABL_family +MEDSCAN urn:agi-aopfc:0000571 000050 APC_C +MEDSCAN urn:agi-aopfc:0000585 000264 IRS +MEDSCAN urn:agi-aopfc:0000586 000248 IGFBP +MEDSCAN urn:agi-aopfc:0000587 000226 Hedgehog +MEDSCAN urn:agi-aopfc:0000615 000252 IL1 +MEDSCAN urn:agi-aopfc:0000704 000339 PDE6 +MEDSCAN urn:agi-complex:CaM%20kinase%20II 000077 CAMK2_complex +MEDSCAN urn:agi-complex:CD3%20complex 000087 CD3 +MEDSCAN urn:agi-complex:CD8 000090 CD8 +MEDSCAN urn:agi-complex:HIF-1 000230 HIF1 +MEDSCAN urn:agi-complex:IFNGR 000263 Interferon_gamma_receptor +MEDSCAN urn:agi-complex:IKK%20complex 000250 IKK_complex +MEDSCAN urn:agi-complex:IL12 000253 IL12 +MEDSCAN urn:agi-complex:inhibin%20A 000257 Inhibin_A +MEDSCAN urn:agi-complex:Luteinizing%20hormone 000276 LH +MEDSCAN urn:agi-complex:MAC-1%20(integrin) 000261 Integrins +MEDSCAN urn:agi-complex:NF-E2 000310 NFE +MEDSCAN urn:agi-complex:platelet%20derived%20growth%20factor%20AA 000347 PDGF_AA +MEDSCAN urn:agi-complex:platelet%20derived%20growth%20factor%20AB 000348 PDGF_AB +MEDSCAN urn:agi-complex:platelet%20derived%20growth%20factor%20BB 000349 PDGF_BB +MEDSCAN urn:agi-complex:prophash-047b61fab6d7e7445346cc84dafcb267 000177 FZD +MEDSCAN urn:agi-complex:prophash-0d528c29d63997f87f62e4fbd9f0b168 000294 mTORC2 +MEDSCAN urn:agi-complex:prophash-0f8242e28423189d7ef714808fdcc121 000233 Histone +MEDSCAN urn:agi-complex:prophash-285b9ff3749679e4d6266406a20973aa 000358 PI3K +MEDSCAN urn:agi-complex:prophash-2b612daa76feb2db86ff39e70449df6b 000387 PRC2_complex +MEDSCAN urn:agi-complex:prophash-2de597c3f4a807f3caeaf02e5f93ce15 000453 STAT +MEDSCAN urn:agi-complex:prophash-40bc2e4348830d6f7bdacd573fd7c388 000147 E2F +MEDSCAN urn:agi-complex:prophash-44f61960049704dc2afb23ff7c324b85 000230 HIF1 +MEDSCAN urn:agi-complex:prophash-4dda466320b1a32b046d823accadbaee 000092 CDK +MEDSCAN urn:agi-complex:prophash-50bd08479c3770278693a51fe379babd 000490 Ubiquitin +MEDSCAN urn:agi-complex:prophash-72ef5fc0ab431a39e0e2915bf55b6e28 000441 SMAD +MEDSCAN urn:agi-complex:prophash-7629c2cdfdf4908b72f13917a7c1551e 000411 RFC +MEDSCAN urn:agi-complex:prophash-763d31b31e177311583df0ac1ea015da 000187 GPCR +MEDSCAN urn:agi-complex:prophash-7e8823afb9ca7870b95633dcb782500b 000220 HDAC +MEDSCAN urn:agi-complex:prophash-8a9e47ee0ee03d8d8b6e029e2fba6896 000074 Cadherin +MEDSCAN urn:agi-complex:prophash-8cfce9bfac3857e6f068d517deadfeaa 000311 NFkappaB +MEDSCAN urn:agi-complex:prophash-8d885376e30916afd0b47ccf1b044e75 000268 JUN_family +MEDSCAN urn:agi-complex:prophash-90a087d4e73b3992c65edfd9f71c6802 000486 Tubulin +MEDSCAN urn:agi-complex:prophash-9e456bf1de2c5eb1107156c96a1450e6 000466 TGFBR +MEDSCAN urn:agi-complex:prophash-aba0c4130764ae7a26054736114e65cd 000386 PRC1_complex +MEDSCAN urn:agi-complex:prophash-bd459ca2937257c9e3f2b75abf22f422 000424 RXR +MEDSCAN urn:agi-complex:prophash-c3bac0781a4430da4cf6721b8f7537d9 000127 CUL +MEDSCAN urn:agi-complex:prophash-cd6413d79122d5489ee4b4e339245b61 000085 CCT_complex +MEDSCAN urn:agi-complex:prophash-d39afef40daf23ad8376b53904c7092c 000376 PPP1 +MEDSCAN urn:agi-complex:prophash-d9fbae788d60df23b6be4a3ead2cbab4 000417 RNApo_II +MEDSCAN urn:agi-complex:prophash-dd63d0a558770b12c9149b4955828f35 000050 APC_C +MEDSCAN urn:agi-complex:prophash-e4ec238e69c3d3292966ac97dbc11086 000477 Troponin +MEDSCAN urn:agi-complex:prophash-e6be10f6a8e79aed1daa4ec2ac191db1 000284 MCM +MEDSCAN urn:agi-complex:prophash-e9fbfd73e486bda4d99b348f72bb4196 000204 GTPase +MEDSCAN urn:agi-complex:prophash-f2e03d3bf1f747adab17ce77b9b5e5b3 000379 PPP2 +MEDSCAN urn:agi-complex:prophash-f472fef3f59301aee0b776702a30f03e 000293 mTORC1 +MEDSCAN urn:agi-complex:prophash-f7a9dc05e48afd7a93466cfbd5504861 000457 SWI_SNF +MEDSCAN urn:agi-complex:prophash-f7e292d6e30998b81cf5f772ab430f11 000075 CALM +MEDSCAN urn:agi-complex:protein%20phosphatase%203 000383 PPP3 +MEDSCAN urn:agi-complex:protein%20phosphatase%20type%201%20complex 000376 PPP1 +MEDSCAN urn:agi-complex:protein%20phosphatase%20type%202A%20complex 000379 PPP2 +MEDSCAN urn:agi-complex:SMAD2%2f3 000443 SMAD2_3 +MEDSCAN urn:agi-protfc:14-3-3 000323 p14_3_3 +MEDSCAN urn:agi-protfc:actins 000009 Actin +MEDSCAN urn:agi-protfc:AMPK 000031 AMPK +MEDSCAN urn:agi-protfc:apolipoprotein 000052 Apolipoprotein +MEDSCAN urn:agi-protfc:bone%20morphogenetic%20protein%20I%20receptor 000069 BMP_receptor_type_I +MEDSCAN urn:agi-protfc:cadherin 000074 Cadherin +MEDSCAN urn:agi-protfc:casein%20kinase%20I 000124 CSNK1 +MEDSCAN urn:agi-protfc:caveolin 000083 CAV +MEDSCAN urn:agi-protfc:checkpoint%20kinase 000098 CHEK +MEDSCAN urn:agi-protfc:chromatin%20remodeling%20complex 000457 SWI_SNF +MEDSCAN urn:agi-protfc:class%20c%20orphan%20receptor 000187 GPCR +MEDSCAN urn:agi-protfc:cullin 000127 CUL +MEDSCAN urn:agi-protfc:cyclin 000130 Cyclin +MEDSCAN urn:agi-protfc:cyclophilins 000134 Cyclophilin +MEDSCAN urn:agi-protfc:cytosolic%20phospholipase%20a2 000366 PLA2 +MEDSCAN urn:agi-protfc:desmoglein 000138 Desmoglein +MEDSCAN urn:agi-protfc:endothelin 000149 EDN +MEDSCAN urn:agi-protfc:F-actin-binding%20protein 000178 F_actin +MEDSCAN urn:agi-protfc:flotillin 000170 FLOT +MEDSCAN urn:agi-protfc:hemoglobin 000227 Hemoglobin +MEDSCAN urn:agi-protfc:histone%20H1 000234 Histone_H1 +MEDSCAN urn:agi-protfc:histone%20H2A 000235 Histone_H2A +MEDSCAN urn:agi-protfc:histone%20H2B 000236 Histone_H2B +MEDSCAN urn:agi-protfc:histone%20H3 000237 Histone_H3 +MEDSCAN urn:agi-protfc:histone%20H4 000238 Histone_H4 +MEDSCAN urn:agi-protfc:histone 000233 Histone +MEDSCAN urn:agi-protfc:interferon 000262 Interferon +MEDSCAN urn:agi-protfc:kallikrein 000271 KLK +MEDSCAN urn:agi-protfc:mglur 000193 GRM +MEDSCAN urn:agi-protfc:myosin%20heavy%20chain 000295 MYH +MEDSCAN urn:agi-protfc:myosin%20light%20chain 000296 MYL +MEDSCAN urn:agi-protfc:neuregulin%20family 000318 NRG +MEDSCAN urn:agi-protfc:p2y%20receptor 000325 P2RY +MEDSCAN urn:agi-protfc:p70rsk 000328 P70S6K +MEDSCAN urn:agi-protfc:p90rsk 000329 P90RSK +MEDSCAN urn:agi-protfc:PDE4%20subfamily 000338 PDE4 +MEDSCAN urn:agi-protfc:phosphodiesterase%20III 000337 PDE3 +MEDSCAN urn:agi-protfc:ppar 000375 PPAR +MEDSCAN urn:agi-protfc:profilin 000355 PFN +MEDSCAN urn:agi-protfc:rab 000397 RAB +MEDSCAN urn:agi-protfc:sarcoplasmic%20reticulum%20calcium%20transporting%20adenosine%20triphosphatase 000430 SERCA +MEDSCAN urn:agi-protfc:shc%20protein 000432 SHC +MEDSCAN urn:agi-protfc:STAT5%20protein 000454 STAT5 +MEDSCAN urn:agi-protfc:sterol%20regulatory%20element%20binding%20protein 000452 SREBF +MEDSCAN urn:agi-protfc:SWI%2fSNF%20family 000457 SWI_SNF +MEDSCAN urn:agi-protfc:thioredoxin 000487 TXN +MEDSCAN urn:agi-protfc:thrombospondins 000467 THBS +MEDSCAN urn:agi-protfc:tubulin 000486 Tubulin +MEDSCAN urn:agi-protfc:ubiquitin 000490 Ubiquitin +MESH C072194 000349 PDGF_BB +MESH D000199 000009 Actin +MESH D003576 000504 ETC_complex_IV +MESH D006657 000233 Histone +MESH D010749 000357 Phosphatase +MESH D011493 000364 PKC +MESH D011948 000461 TCR +MESH D014450 000503 ETC_complex_III +MESH D016695 000198 Glycosyltransferase +MESH D018808 000048 AP1 +MESH D018844 000092 CDK +MESH D020169 000081 Caspase +MESH D025261 000505 ETC_complex_V +MESH D042963 000502 ETC_complex_II +MESH D042967 000501 ETC_complex_I +MESH D046988 000394 Proteasome +NCIT C104194 000132 Cyclin_D +NCIT C104197 000133 Cyclin_E +NCIT C104199 000251 IKK_family +NCIT C104676 000473 TN +NCIT C105947 000281 MAP2K +NCIT C105952 000051 APOA +NCIT C107433 000338 PDE4 +NCIT C107559 000104 CK2 +NCIT C112049 000502 ETC_complex_II +NCIT C112051 000080 Carboxylesterase +NCIT C113839 000229 HIF +NCIT C116019 000044 AMPK_alpha +NCIT C118184 000501 ETC_complex_I +NCIT C118481 000024 ALDH +NCIT C118892 000174 FOXO +NCIT C120030 000481 Tryptase +NCIT C120493 000226 Hedgehog +NCIT C124129 000109 COL1 +NCIT C126114 000372 PLCG +NCIT C126122 000188 GPIb_IX_V +NCIT C129655 000484 TUBB +NCIT C16258 000009 Actin +NCIT C16264 000017 ADCY +NCIT C16272 000018 ADH +NCIT C16373 000074 Cadherin +NCIT C16375 000075 CALM +NCIT C16376 000161 ERK +NCIT C16376 000283 MAPK +NCIT C16377 000079 CAPN +NCIT C16448 000110 COL4 +NCIT C16479 000363 PKA +NCIT C16511 000141 DNA_polymerase_delta +NCIT C16641 000195 GST +NCIT C16650 000204 GTPase +NCIT C16653 000205 GUCY +NCIT C16676 000227 Hemoglobin +NCIT C16682 000220 HDAC +NCIT C16683 000234 Histone_H1 +NCIT C16684 000235 Histone_H2A +NCIT C16685 000237 Histone_H3 +NCIT C16686 000238 Histone_H4 +NCIT C16687 000233 Histone +NCIT C16692 000239 HLA_DR +NCIT C16748 000261 Integrins +NCIT C16965 000393 Protease +NCIT C16979 000366 PLA2 +NCIT C16981 000357 Phosphatase +NCIT C17017 000364 PKC +NCIT C17061 000404 RAS +NCIT C17062 000021 ADRB +NCIT C17065 000461 TCR +NCIT C17066 000143 DRD +NCIT C17078 000468 THR +NCIT C17219 000486 Tubulin +NCIT C17227 000490 Ubiquitin +NCIT C17270 000358 PI3K +NCIT C17274 000067 BMP +NCIT C17286 000120 CREB +NCIT C17293 000496 VEGFR +NCIT C17297 000168 FGFR +NCIT C17298 000182 GAP +NCIT C17322 000343 PDGFR +NCIT C17343 000479 Troponin_I +NCIT C17349 000130 Cyclin +NCIT C17380 000311 NFkappaB +NCIT C17450 000048 AP1 +NCIT C17458 000214 G_protein +NCIT C17487 000086 CD16 +NCIT C17494 000186 GEF +NCIT C17532 000403 RAR +NCIT C17534 000424 RXR +NCIT C17583 000249 IKB +NCIT C17660 000423 RTK +NCIT C17690 000230 HIF1 +NCIT C17763 000160 ERBB +NCIT C17766 000241 HSP90 +NCIT C17767 000092 CDK +NCIT C17903 000309 NFAT +NCIT C18153 000081 Caspase +NCIT C18162 000152 EIF2B +NCIT C18164 000291 MMP +NCIT C18239 000187 GPCR +NCIT C18308 000088 CD32 +NCIT C18434 000476 TOP2 +NCIT C18492 000094 CDKN +NCIT C18606 000158 Ephrin_receptor +NCIT C19275 000213 G_i_alpha +NCIT C19618 000453 STAT +NCIT C19836 000368 PLA2G4 +NCIT C19866 000386 PRC1_complex +NCIT C20448 000342 PDGF +NCIT C129646 000495 VEGF +NCIT C20456 000010 Activin +NCIT C20466 000099 Chemokine +NCIT C20493 000262 Interferon +NCIT C20495 000247 IFNB +NCIT C20506 000252 IL1 +NCIT C20514 000253 IL12 +NCIT C20591 000457 SWI_SNF +NCIT C2275 000219 hCG +NCIT C2276 000256 Inhibin +NCIT C2277 000257 Inhibin_A +NCIT C2278 000258 Inhibin_B +NCIT C25184 000275 LDH +NCIT C25186 000225 HDL +NCIT C26034 000504 ETC_complex_IV +NCIT C26233 000192 GRK +NCIT C26360 000161 ERK +NCIT C28687 000122 CRSP +NCIT C38041 000480 Troponin_T +NCIT C38897 000087 CD3 +NCIT C41625 000023 AKT +NCIT C736 000354 Pertussis_toxin +NCIT C94701 000031 AMPK +NCIT C95114 000181 Gamma_secretase +NCIT C95947 000416 RNApo_I +NCIT C95948 000417 RNApo_II +NCIT C96314 000293 mTORC1 +NCIT C96315 000294 mTORC2 +NXP FA:00078 000009 Actin +NXP FA:00093 000004 ACAD +NXP FA:00209 000463 TFAP2 +NXP FA:00406 000097 CEBP +NXP FA:00408 000173 FOS_family +NXP FA:00421 000385 PPP3R +NXP FA:00440 000075 CALM +NXP FA:00489 000083 CAV +NXP FA:00653 000106 CNKSR +NXP FA:00787 000127 CUL +NXP FA:00803 000337 PDE3 +NXP FA:00804 000338 PDE4 +NXP FA:00815 000130 Cyclin +NXP FA:00818 000132 Cyclin_D +NXP FA:00819 000133 Cyclin_E +NXP FA:00921 000153 EIF4A +NXP FA:01112 000157 ENO +NXP FA:01121 000159 EPN +NXP FA:01400 000211 G_gamma +NXP FA:01553 000190 GPX +NXP FA:01669 000195 GST +NXP FA:01729 000226 Hedgehog +NXP FA:01762 000235 Histone_H2A +NXP FA:01764 000237 Histone_H3 +NXP FA:01765 000238 Histone_H4 +NXP FA:01820 000252 IL1 +NXP FA:01869 000259 INS +NXP FA:02022 000275 LDH +NXP FA:02159 000434 SLC2A +NXP FA:02187 000284 MCM +NXP FA:02504 000316 NOS +NXP FA:02506 000317 Notch +NXP FA:02630 000324 P2RX +NXP FA:02632 000327 p53_family +NXP FA:02660 000332 PARV +NXP FA:02762 000156 ELA +NXP FA:02767 000481 Tryptase +NXP FA:02840 000366 PLA2 +NXP FA:03001 000376 PPP1 +NXP FA:03065 000364 PKC +NXP FA:03066 000398 RAC +NXP FA:03071 000031 AMPK +NXP FA:03072 000076 CAMK +NXP FA:03078 000362 PIM +NXP FA:03083 000124 CSNK1 +NXP FA:03087 000194 GSK3 +NXP FA:03091 000146 DYRK +NXP FA:03101 000104 CK2 +NXP FA:03104 000251 IKK_family +NXP FA:03114 000399 RAF +NXP FA:03124 000158 Ephrin_receptor +NXP FA:03128 000260 INSR +NXP FA:03129 000266 JAK +NXP FA:03130 000420 ROR +NXP FA:03131 000451 SRC +NXP FA:03483 000428 SAA +NXP FA:03579 000431 SERPINB +NXP FA:03661 000397 RAB +NXP FA:03663 000404 RAS +NXP FA:03668 000414 RHO +NXP FA:03672 000435 SLRP +NXP FA:03673 000436 SLRP_1 +NXP FA:03674 000437 SLRP_2 +NXP FA:03675 000438 SLRP_3 +NXP FA:03676 000439 SLRP_4 +NXP FA:03677 000440 SLRP_5 +NXP FA:03686 000444 SMC1 +NXP FA:03943 000460 TCF_LEF +NXP FA:03964 000473 TN +NXP FA:03989 000465 TGFB +NXP FA:04000 000487 TXN +NXP FA:04014 000470 TIAM +NXP FA:04239 000486 Tubulin +NXP FA:04243 000474 TNF +NXP FA:04276 000490 Ubiquitin +NXP FA:04282 000489 UBE2 +NXP FA:04686 000497 Wnt +NXP FA:04773 000401 RAP1 +PF PF00012 000244 HSPA +PF PF00022 000009 Actin +PF PF00028 000074 Cadherin +PF PF00066 000317 Notch +PF PF00071 000404 RAS +PF PF00110 000497 Wnt +PF PF00143 000262 Interferon +PF PF00146 000301 NADH_dehydrogenase +PF PF00167 000167 FGF +PF PF00178 000163 ETS +PF PF00183 000241 HSP90 +PF PF00219 000248 IGFBP +PF PF00229 000474 TNF +PF PF00235 000355 PFN +PF PF00244 000323 p14_3_3 +PF PF00255 000190 GPX +PF PF00277 000428 SAA +PF PF00320 000184 GATA +PF PF00322 000149 EDN +PF PF00340 000252 IL1 +PF PF00465 000018 ADH +PF PF00493 000284 MCM +PF PF00503 000209 G_alpha +PF PF00616 000407 RasGAP +PF PF00644 000331 PARP +PF PF00656 000081 Caspase +PF PF00864 000324 P2RX +PF PF00870 000327 p53_family +PF PF00888 000127 CUL +PF PF00963 000108 Cohesin +PF PF01146 000083 CAV +PF PF01442 000052 Apolipoprotein +PF PF01534 000177 FZD +PF PF01756 000007 ACOX +PF PF02046 000115 COX6A +PF PF02158 000318 NRG +PF PF02174 000264 IRS +PF PF02234 000094 CDKN +PF PF02238 000117 COX7A +PF PF02285 000119 COX8 +PF PF02297 000116 COX6B +PF PF02377 000145 DVL +PF PF02460 000333 Patched +PF PF02545 000279 MAF +PF PF02608 000067 BMP +PF PF02827 000365 PKI +PF PF02854 000155 EIF4G +PF PF02936 000114 COX4 +PF PF03039 000253 IL12 +PF PF03096 000307 NDRG +PF PF05392 000118 COX7B +PF PF08137 000145 DVL +PF PF08562 000121 CRISP +PF PF08841 000136 DDR +PF PF11413 000230 HIF1 +PF PF12483 000148 E3_Ub_ligase +PF PF15975 000170 FLOT +RE R-HSA-1031694 000089 CD64 +RE R-HSA-109631 000197 GTF2F +RE R-HSA-109633 000196 GTF2E +RE R-HSA-109782 000404 RAS +RE R-HSA-109783 000404 RAS +RE R-HSA-109796 000404 RAS +RE R-HSA-111854 000370 PLCB +RE R-HSA-111864 000212 G_i +RE R-HSA-111864 000213 G_i_alpha +RE R-HSA-111921 000390 PRKAR +RE R-HSA-111923 000390 PRKAR +RE R-HSA-111952 000336 PDE1 +RE R-HSA-111953 000336 PDE1 +RE R-HSA-111960 000338 PDE4 +RE R-HSA-114525 000208 G_12_alpha +RE R-HSA-114534 000215 G_q +RE R-HSA-114534 000216 G_q_alpha +RE R-HSA-114547 000207 G_12 +RE R-HSA-114556 000215 G_q +RE R-HSA-114556 000216 G_q_alpha +RE R-HSA-114617 000169 Fibrinogen +RE R-HSA-114618 000169 Fibrinogen +RE R-HSA-114657 000465 TGFB +RE R-HSA-114668 000188 GPIb_IX_V +RE R-HSA-1168365 000372 PLCG +RE R-HSA-1168621 000250 IKK_complex +RE R-HSA-1169086 000372 PLCG +RE R-HSA-1169089 000372 PLCG +RE R-HSA-1218829 000243 HSP90AA +RE R-HSA-1221657 000243 HSP90AA +RE R-HSA-1227956 000319 NRG_1_2 +RE R-HSA-1227957 000318 NRG +RE R-HSA-1234130 000229 HIF +RE R-HSA-1234147 000231 HIF_alpha +RE R-HSA-1236898 000089 CD64 +RE R-HSA-1236905 000089 CD64 +RE R-HSA-1247495 000319 NRG_1_2 +RE R-HSA-1248743 000319 NRG_1_2 +RE R-HSA-1250100 000326 p38 +RE R-HSA-1250102 000326 p38 +RE R-HSA-1268261 000161 ERK +RE R-HSA-1362227 000464 TFDP +RE R-HSA-139848 000324 P2RX +RE R-HSA-139933 000169 Fibrinogen +RE R-HSA-139934 000169 Fibrinogen +RE R-HSA-140586 000169 Fibrinogen +RE R-HSA-140812 000469 Thrombin_antithrombin +RE R-HSA-140871 000469 Thrombin_antithrombin +RE R-HSA-140874 000469 Thrombin_antithrombin +RE R-HSA-140919 000169 Fibrinogen +RE R-HSA-1445138 000323 p14_3_3 +RE R-HSA-1449672 000013 Activin_B +RE R-HSA-1449688 000256 Inhibin +RE R-HSA-1449698 000012 Activin_AB +RE R-HSA-1469978 000454 STAT5 +RE R-HSA-1504201 000145 DVL +RE R-HSA-157462 000133 Cyclin_E +RE R-HSA-162690 000189 GPIT +RE R-HSA-163538 000377 PPP1C +RE R-HSA-163679 000042 AMPK_A2B2G2 +RE R-HSA-163736 000042 AMPK_A2B2G2 +RE R-HSA-163747 000042 AMPK_A2B2G2 +RE R-HSA-165175 000482 TSC +RE R-HSA-165180 000482 TSC +RE R-HSA-1655720 000452 SREBF +RE R-HSA-1655725 000452 SREBF +RE R-HSA-1655726 000452 SREBF +RE R-HSA-1655730 000452 SREBF +RE R-HSA-1655732 000452 SREBF +RE R-HSA-1655734 000452 SREBF +RE R-HSA-165631 000502 ETC_complex_II +RE R-HSA-165990 000381 PPP2R_A +RE R-HSA-165997 000381 PPP2R_A +RE R-HSA-167023 000432 SHC +RE R-HSA-167204 000404 RAS +RE R-HSA-167215 000448 SOS +RE R-HSA-167409 000210 G_beta +RE R-HSA-167410 000212 G_i +RE R-HSA-167410 000213 G_i_alpha +RE R-HSA-167413 000212 G_i +RE R-HSA-167413 000213 G_i_alpha +RE R-HSA-167438 000212 G_i +RE R-HSA-167438 000213 G_i_alpha +RE R-HSA-167442 000211 G_gamma +RE R-HSA-1678828 000155 EIF4G +RE R-HSA-168113 000250 IKK_complex +RE R-HSA-169289 000161 ERK +RE R-HSA-169291 000161 ERK +RE R-HSA-170089 000131 Cyclin_A +RE R-HSA-170108 000091 CDC25 +RE R-HSA-170994 000400 RAL +RE R-HSA-170998 000400 RAL +RE R-HSA-171016 000326 p38 +RE R-HSA-171172 000443 SMAD2_3 +RE R-HSA-171182 000443 SMAD2_3 +RE R-HSA-173584 000072 C1 +RE R-HSA-173615 000072 C1 +RE R-HSA-173617 000072 C1 +RE R-HSA-173728 000278 MAC +RE R-HSA-174074 000131 Cyclin_A +RE R-HSA-174454 000411 RFC +RE R-HSA-177105 000443 SMAD2_3 +RE R-HSA-177656 000312 NFkappaB_1 +RE R-HSA-177662 000312 NFkappaB_1 +RE R-HSA-177663 000250 IKK_complex +RE R-HSA-179508 000025 ALDO +RE R-HSA-182582 000132 Cyclin_D +RE R-HSA-182700 000132 Cyclin_D +RE R-HSA-184196 000349 PDGF_BB +RE R-HSA-184198 000349 PDGF_BB +RE R-HSA-184203 000347 PDGF_AA +RE R-HSA-184204 000349 PDGF_BB +RE R-HSA-184206 000349 PDGF_BB +RE R-HSA-186769 000343 PDGFR +RE R-HSA-186769 000345 PDGFR_AB +RE R-HSA-186770 000343 PDGFR +RE R-HSA-186770 000345 PDGFR_AB +RE R-HSA-186791 000343 PDGFR +RE R-HSA-186791 000345 PDGFR_AB +RE R-HSA-186792 000343 PDGFR +RE R-HSA-186792 000345 PDGFR_AB +RE R-HSA-186799 000346 PDGFR_BB +RE R-HSA-186805 000346 PDGFR_BB +RE R-HSA-186816 000344 PDGFR_AA +RE R-HSA-186817 000344 PDGFR_AA +RE R-HSA-186821 000343 PDGFR +RE R-HSA-186821 000345 PDGFR_AB +RE R-HSA-187493 000133 Cyclin_E +RE R-HSA-189382 000240 HMOX +RE R-HSA-189828 000326 p38 +RE R-HSA-1911410 000055 ARRB +RE R-HSA-1911440 000317 Notch +RE R-HSA-1911472 000317 Notch +RE R-HSA-1911474 000317 Notch +RE R-HSA-1911547 000317 Notch +RE R-HSA-1911550 000317 Notch +RE R-HSA-195361 000495 VEGF +RE R-HSA-195376 000495 VEGF +RE R-HSA-196206 000379 PPP2 +RE R-HSA-198358 000194 GSK3 +RE R-HSA-198373 000194 GSK3 +RE R-HSA-198701 000161 ERK +RE R-HSA-198899 000090 CD8 +RE R-HSA-200408 000042 AMPK_A2B2G2 +RE R-HSA-200563 000005 ACC +RE R-HSA-201465 000070 BMP_receptor_type_II +RE R-HSA-201689 000145 DVL +RE R-HSA-201711 000104 CK2 +RE R-HSA-201725 000145 DVL +RE R-HSA-201779 000384 PPP3C +RE R-HSA-201798 000384 PPP3C +RE R-HSA-201804 000070 BMP_receptor_type_II +RE R-HSA-202052 000023 AKT +RE R-HSA-202072 000023 AKT +RE R-HSA-202074 000023 AKT +RE R-HSA-202088 000023 AKT +RE R-HSA-202513 000250 IKK_complex +RE R-HSA-202562 000250 IKK_complex +RE R-HSA-202877 000082 Caspase_3_7 +RE R-HSA-2029095 000372 PLCG +RE R-HSA-2029115 000494 VAV +RE R-HSA-203947 000353 PDK +RE R-HSA-206893 000011 Activin_A +RE R-HSA-2089970 000109 COL1 +RE R-HSA-212420 000317 Notch +RE R-HSA-2127310 000111 COL5 +RE R-HSA-2127389 000110 COL4 +RE R-HSA-2127422 000111 COL5 +RE R-HSA-2151208 000045 AMPK_beta +RE R-HSA-2151212 000046 AMPK_gamma +RE R-HSA-2151213 000044 AMPK_alpha +RE R-HSA-215989 000273 Laminin_111 +RE R-HSA-216001 000274 Laminin_332 +RE R-HSA-2176482 000443 SMAD2_3 +RE R-HSA-2187329 000443 SMAD2_3 +RE R-HSA-2187387 000443 SMAD2_3 +RE R-HSA-2213185 000142 DNM +RE R-HSA-2220790 000274 Laminin_332 +RE R-HSA-2316451 000046 AMPK_gamma +RE R-HSA-2317310 000023 AKT +RE R-HSA-2317317 000023 AKT +RE R-HSA-2317329 000023 AKT +RE R-HSA-2395330 000465 TGFB +RE R-HSA-2396039 000109 COL1 +RE R-HSA-2396161 000109 COL1 +RE R-HSA-2396179 000109 COL1 +RE R-HSA-2396183 000109 COL1 +RE R-HSA-2396256 000109 COL1 +RE R-HSA-2396260 000109 COL1 +RE R-HSA-2396334 000109 COL1 +RE R-HSA-2396451 000109 COL1 +RE R-HSA-2396456 000109 COL1 +RE R-HSA-2396478 000109 COL1 +RE R-HSA-2399520 000109 COL1 +RE R-HSA-2399659 000274 Laminin_332 +RE R-HSA-2400006 000023 AKT +RE R-HSA-2400013 000023 AKT +RE R-HSA-2422450 000161 ERK +RE R-HSA-2426131 000314 NFY +RE R-HSA-2426276 000349 PDGF_BB +RE R-HSA-2426371 000273 Laminin_111 +RE R-HSA-2428941 000109 COL1 +RE R-HSA-2445131 000264 IRS +RE R-HSA-2445139 000264 IRS +RE R-HSA-2457842 000323 p14_3_3 +RE R-HSA-2470478 000010 Activin +RE R-HSA-2470478 000012 Activin_AB +RE R-HSA-2470491 000010 Activin +RE R-HSA-2470491 000012 Activin_AB +RE R-HSA-2470494 000010 Activin +RE R-HSA-2470494 000012 Activin_AB +RE R-HSA-2530496 000172 FNT +RE R-HSA-2533911 000274 Laminin_332 +RE R-HSA-264974 000164 EXOC +RE R-HSA-2672035 000473 TN +RE R-HSA-2681744 000473 TN +RE R-HSA-2685653 000372 PLCG +RE R-HSA-2685656 000409 RASGRP +RE R-HSA-2990868 000101 Cholinesterase +RE R-HSA-2993807 000392 Propionyl_CoA_carboxylase +RE R-HSA-2993809 000392 Propionyl_CoA_carboxylase +RE R-HSA-3132719 000163 ETS +RE R-HSA-3132724 000163 ETS +RE R-HSA-3200029 000163 ETS +RE R-HSA-3238268 000497 Wnt +RE R-HSA-3238374 000497 Wnt +RE R-HSA-3247790 000497 Wnt +RE R-HSA-3247824 000497 Wnt +RE R-HSA-3247835 000497 Wnt +RE R-HSA-3299546 000460 TCF_LEF +RE R-HSA-3323122 000392 Propionyl_CoA_carboxylase +RE R-HSA-3323155 000392 Propionyl_CoA_carboxylase +RE R-HSA-3371429 000242 HSP90A +RE R-HSA-349716 000306 NCOR +RE R-HSA-3640819 000062 AXIN +RE R-HSA-3640837 000101 Cholinesterase +RE R-HSA-3640863 000062 AXIN +RE R-HSA-3656389 000161 ERK +RE R-HSA-374848 000215 G_q +RE R-HSA-374848 000216 G_q_alpha +RE R-HSA-376002 000003 ABL_family +RE R-HSA-3772407 000145 DVL +RE R-HSA-3772502 000062 AXIN +RE R-HSA-378941 000219 hCG +RE R-HSA-378947 000175 FSH +RE R-HSA-378969 000276 LH +RE R-HSA-380748 000349 PDGF_BB +RE R-HSA-380751 000349 PDGF_BB +RE R-HSA-380759 000348 PDGF_AB +RE R-HSA-380759 000349 PDGF_BB +RE R-HSA-380931 000031 AMPK +RE R-HSA-380934 000031 AMPK +RE R-HSA-380961 000031 AMPK +RE R-HSA-381204 000314 NFY +RE R-HSA-381844 000044 AMPK_alpha +RE R-HSA-381845 000044 AMPK_alpha +RE R-HSA-381851 000046 AMPK_gamma +RE R-HSA-381854 000045 AMPK_beta +RE R-HSA-381855 000482 TSC +RE R-HSA-381926 000342 PDGF +RE R-HSA-381930 000351 PDGF_DD +RE R-HSA-381935 000349 PDGF_BB +RE R-HSA-381936 000342 PDGF +RE R-HSA-381938 000349 PDGF_BB +RE R-HSA-381941 000350 PDGF_CC +RE R-HSA-3858467 000145 DVL +RE R-HSA-3858479 000145 DVL +RE R-HSA-387074 000349 PDGF_BB +RE R-HSA-388544 000149 EDN +RE R-HSA-390455 000085 CCT_complex +RE R-HSA-390474 000085 CCT_complex +RE R-HSA-390532 000478 Troponin_C +RE R-HSA-390541 000479 Troponin_I +RE R-HSA-390546 000480 Troponin_T +RE R-HSA-390583 000477 Troponin +RE R-HSA-390585 000477 Troponin +RE R-HSA-390587 000478 Troponin_C +RE R-HSA-390643 000021 ADRB +RE R-HSA-390664 000020 ADRA2 +RE R-HSA-390670 000021 ADRB +RE R-HSA-390700 000020 ADRA2 +RE R-HSA-392712 000349 PDGF_BB +RE R-HSA-399713 000191 GRIA +RE R-HSA-399987 000215 G_q +RE R-HSA-399987 000216 G_q_alpha +RE R-HSA-399992 000215 G_q +RE R-HSA-399992 000216 G_q_alpha +RE R-HSA-400000 000215 G_q +RE R-HSA-400000 000216 G_q_alpha +RE R-HSA-400008 000215 G_q +RE R-HSA-400008 000216 G_q_alpha +RE R-HSA-400062 000211 G_gamma +RE R-HSA-400093 000210 G_beta +RE R-HSA-416323 000191 GRIA +RE R-HSA-417004 000077 CAMK2_complex +RE R-HSA-417004 000078 CAMK2_family +RE R-HSA-418312 000430 SERCA +RE R-HSA-418379 000391 PRKG +RE R-HSA-418540 000340 PDE7 +RE R-HSA-418541 000341 PDE8 +RE R-HSA-418570 000207 G_12 +RE R-HSA-418570 000208 G_12_alpha +RE R-HSA-418572 000207 G_12 +RE R-HSA-418572 000208 G_12_alpha +RE R-HSA-419057 000419 ROCK +RE R-HSA-419160 000414 RHO +RE R-HSA-419161 000414 RHO +RE R-HSA-419164 000414 RHO +RE R-HSA-419294 000316 NOS +RE R-HSA-419346 000427 S1PR +RE R-HSA-419401 000427 S1PR +RE R-HSA-419619 000242 HSP90A +RE R-HSA-420516 000193 GRM +RE R-HSA-420519 000193 GRM +RE R-HSA-420974 000191 GRIA +RE R-HSA-421001 000191 GRIA +RE R-HSA-426070 000140 DGK +RE R-HSA-427905 000430 SERCA +RE R-HSA-428110 000374 PPAP2 +RE R-HSA-428475 000330 PAK +RE R-HSA-429349 000259 INS +RE R-HSA-429352 000259 INS +RE R-HSA-429384 000259 INS +RE R-HSA-429407 000259 INS +RE R-HSA-429472 000259 INS +RE R-HSA-429842 000153 EIF4A +RE R-HSA-430172 000494 VAV +RE R-HSA-432792 000077 CAMK2_complex +RE R-HSA-432792 000078 CAMK2_family +RE R-HSA-434632 000494 VAV +RE R-HSA-442272 000494 VAV +RE R-HSA-442295 000494 VAV +RE R-HSA-442734 000408 RASGRF +RE R-HSA-444796 000077 CAMK2_complex +RE R-HSA-444796 000078 CAMK2_family +RE R-HSA-445134 000333 Patched +RE R-HSA-445374 000077 CAMK2_complex +RE R-HSA-445374 000078 CAMK2_family +RE R-HSA-445744 000252 IL1 +RE R-HSA-446847 000142 DNM +RE R-HSA-446849 000329 P90RSK +RE R-HSA-447102 000253 IL12 +RE R-HSA-448866 000285 MEF2 +RE R-HSA-448868 000285 MEF2 +RE R-HSA-450226 000267 JNK +RE R-HSA-450253 000267 JNK +RE R-HSA-450289 000267 JNK +RE R-HSA-451402 000014 ACTN +RE R-HSA-452094 000454 STAT5 +RE R-HSA-4551456 000391 PRKG +RE R-HSA-4551462 000391 PRKG +RE R-HSA-4641132 000062 AXIN +RE R-HSA-4652685 000145 DVL +RE R-HSA-4687776 000419 ROCK +RE R-HSA-507919 000454 STAT5 +RE R-HSA-507929 000454 STAT5 +RE R-HSA-508012 000454 STAT5 +RE R-HSA-5082395 000242 HSP90A +RE R-HSA-5082406 000243 HSP90AA +RE R-HSA-5083623 000125 CSNK2 +RE R-HSA-5083624 000125 CSNK2 +RE R-HSA-5138439 000105 Clathrin +RE R-HSA-5138447 000105 Clathrin +RE R-HSA-517388 000177 FZD +RE R-HSA-5218789 000494 VAV +RE R-HSA-5262981 000250 IKK_complex +RE R-HSA-5323539 000460 TCF_LEF +RE R-HSA-5333713 000105 Clathrin +RE R-HSA-5336141 000047 Annexin_II_heterotetramer +RE R-HSA-5340329 000494 VAV +RE R-HSA-5358286 000226 Hedgehog +RE R-HSA-5358318 000226 Hedgehog +RE R-HSA-5358332 000226 Hedgehog +RE R-HSA-5362382 000226 Hedgehog +RE R-HSA-5362391 000226 Hedgehog +RE R-HSA-5610566 000390 PRKAR +RE R-HSA-5610568 000390 PRKAR +RE R-HSA-5610577 000017 ADCY +RE R-HSA-5610578 000017 ADCY +RE R-HSA-5618088 000242 HSP90A +RE R-HSA-5623453 000164 EXOC +RE R-HSA-5656056 000171 FLRT +RE R-HSA-5658216 000407 RasGAP +RE R-HSA-5658219 000449 SPRED +RE R-HSA-5672337 000482 TSC +RE R-HSA-5672686 000286 MEK +RE R-HSA-5672705 000286 MEK +RE R-HSA-5672708 000399 RAF +RE R-HSA-5672716 000286 MEK +RE R-HSA-5672721 000286 MEK +RE R-HSA-5672726 000399 RAF +RE R-HSA-5674134 000399 RAF +RE R-HSA-5674136 000399 RAF +RE R-HSA-5674338 000161 ERK +RE R-HSA-5674340 000161 ERK +RE R-HSA-5674341 000161 ERK +RE R-HSA-5674489 000286 MEK +RE R-HSA-5675361 000161 ERK +RE R-HSA-5675363 000161 ERK +RE R-HSA-5682664 000056 ATG4 +RE R-HSA-5693120 000064 BCKDC +RE R-HSA-5696998 000131 Cyclin_A +RE R-HSA-6783051 000131 Cyclin_A +RE R-HSA-6792583 000064 BCKDC +RE R-HSA-6793931 000276 LH +RE R-HSA-6793934 000276 LH +RE R-HSA-6798076 000327 p53_family +RE R-HSA-6798078 000327 p53_family +RE R-HSA-6802607 000404 RAS +RE R-HSA-6802608 000404 RAS +RE R-HSA-6805064 000125 CSNK2 +RE R-HSA-6805066 000104 CK2 +RE R-HSA-6805073 000125 CSNK2 +RE R-HSA-6805467 000031 AMPK +RE R-HSA-6813837 000133 Cyclin_E +RE R-HSA-6814207 000210 G_beta +RE R-HSA-6814413 000210 G_beta +RE R-HSA-6814694 000138 Desmoglein +RE R-HSA-68373 000133 Cyclin_E +RE R-HSA-68436 000411 RFC +RE R-HSA-68450 000141 DNA_polymerase_delta +RE R-HSA-68462 000421 RPA +RE R-HSA-69261 000091 CDC25 +RE R-HSA-70019 000064 BCKDC +RE R-HSA-70990 000502 ETC_complex_II +RE R-HSA-71025 000392 Propionyl_CoA_carboxylase +RE R-HSA-71026 000392 Propionyl_CoA_carboxylase +RE R-HSA-72526 000152 EIF2B +RE R-HSA-727820 000250 IKK_complex +RE R-HSA-74674 000259 INS +RE R-HSA-74688 000360 PI3K_p85 +RE R-HSA-749499 000215 G_q +RE R-HSA-749499 000216 G_q_alpha +RE R-HSA-75202 000131 Cyclin_A +RE R-HSA-77385 000259 INS +RE R-HSA-8847714 000138 Desmoglein +RE R-HSA-8848649 000079 CAPN +RE R-HSA-8848668 000079 CAPN +RE R-HSA-8849894 000170 FLOT +RE R-HSA-8850524 000210 G_beta +RE R-HSA-8852568 000278 MAC +RE R-HSA-8855211 000061 Augmin +RE R-HSA-8861873 000324 P2RX +RE R-HSA-8864040 000343 PDGFR +RE R-HSA-8864040 000345 PDGFR_AB +RE R-HSA-8864046 000346 PDGFR_BB +RE R-HSA-8864283 000463 TFAP2 +RE R-HSA-8864286 000463 TFAP2 +RE R-HSA-8865622 000454 STAT5 +RE R-HSA-8866229 000022 ADRBK +RE R-HSA-8868235 000142 DNM +RE R-HSA-8868609 000142 DNM +RE R-HSA-8870680 000169 Fibrinogen +RE R-HSA-8936837 000232 HIF_beta +RE R-HSA-8938866 000132 Cyclin_D +RE R-HSA-8941923 000095 CDKN1 +RE R-HSA-8942604 000095 CDKN1 +RE R-HSA-8944354 000460 TCF_LEF +RE R-HSA-8948131 000095 CDKN1 +RE R-HSA-8950122 000253 IL12 +RE R-HSA-8950228 000253 IL12 +RE R-HSA-8950694 000253 IL12 +RE R-HSA-8951427 000460 TCF_LEF +RE R-HSA-909688 000246 IFNA +RE R-HSA-936779 000057 ATP1A +RE R-HSA-936820 000058 ATP1B +RE R-HSA-976075 000148 E3_Ub_ligase +RE R-HSA-996770 000184 GATA +SIGNOR SIGNOR-PF1 000161 ERK +SIGNOR SIGNOR-PF10 000145 DVL +SIGNOR SIGNOR-PF11 000177 FZD +SIGNOR SIGNOR-PF12 000311 NFkappaB +SIGNOR SIGNOR-PF13 000330 PAK +SIGNOR SIGNOR-PF14 000418 ROBO +SIGNOR SIGNOR-PF15 000267 JNK +SIGNOR SIGNOR-PF16 000326 p38 +SIGNOR SIGNOR-PF17 000389 PRKAC +SIGNOR SIGNOR-PF18 000384 PPP3C +SIGNOR SIGNOR-PF2 000277 LPAR +SIGNOR SIGNOR-PF20 000472 TLR +SIGNOR SIGNOR-PF21 000458 TAOK +SIGNOR SIGNOR-PF22 000462 TEAD +SIGNOR SIGNOR-PF23 000168 FGFR +SIGNOR SIGNOR-PF24 000023 AKT +SIGNOR SIGNOR-PF25 000286 MEK +SIGNOR SIGNOR-PF26 000329 P90RSK +SIGNOR SIGNOR-PF27 000174 FOXO +SIGNOR SIGNOR-PF29 000445 SMURF +SIGNOR SIGNOR-PF3 000211 G_gamma +SIGNOR SIGNOR-PF30 000317 Notch +SIGNOR SIGNOR-PF31 000435 SLRP +SIGNOR SIGNOR-PF32 000451 SRC +SIGNOR SIGNOR-PF33 000187 GPCR +SIGNOR SIGNOR-PF34 000362 PIM +SIGNOR SIGNOR-PF35 000442 SMAD1_5_9 +SIGNOR SIGNOR-PF4 000210 G_beta +SIGNOR SIGNOR-PF5 000465 TGFB +SIGNOR SIGNOR-PF6 000044 AMPK_alpha +SIGNOR SIGNOR-PF7 000323 p14_3_3 +SIGNOR SIGNOR-PF8 000167 FGF +SIGNOR SIGNOR-PF9 000068 BMP_receptor diff --git a/famplex/resources/famplex.obo b/famplex/resources/famplex.obo new file mode 100644 index 000000000..56f1b835b --- /dev/null +++ b/famplex/resources/famplex.obo @@ -0,0 +1,8520 @@ +format-version: 1.2 +date: 21:07:2019 16:45 + +[Typedef] +id: part_of +name: part of +namespace: external +xref: BFO:0000050 +is_transitive: true + +[Typedef] +id: inverse_is_a +name: inverse is_a + +[Typedef] +id: has_part +name: has part + +[Term] +id: FPLX:000000 +name: famplex + +[Term] +id: FPLX:000001 +name: 9-1-1 +synonym: "(9-1-1) complex" EXACT [] +synonym: "9-1-1 complex" EXACT [] +synonym: "9-1-1" EXACT [] +synonym: "h9-1-1 complex" EXACT [] +xref: BEL:"9-1-1 Complex" +is_a: FPLX:000000 ! famplex +relationship: has_part HGNC:5309 ! HUS1 +relationship: has_part HGNC:9806 ! RAD1 +relationship: has_part HGNC:9827 ! RAD9A + +[Term] +id: FPLX:000002 +name: A4GALT-family +is_a: FPLX:000198 ! Glycosyltransferase +relationship: inverse_is_a HGNC:18149 ! A4GALT +relationship: inverse_is_a HGNC:17968 ! A4GNT + +[Term] +id: FPLX:000003 +name: ABL-family +synonym: "ABL family" EXACT [] +synonym: "ABL" EXACT [] +xref: IP:IPR015015 +xref: MEDSCAN:urn:agi-aopfc:0000567 +xref: RE:R-HSA-376002 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:76 ! ABL1 +relationship: inverse_is_a HGNC:77 ! ABL2 + +[Term] +id: FPLX:000004 +name: ACAD +synonym: "ACAD" EXACT [] +synonym: "acyl CoA dehydrogenase" EXACT [] +synonym: "acyl-CoA dehydrogenase" EXACT [] +xref: BEL:"ACAD Family" +xref: ECCODE:1.3.8.7 +xref: NEXTPROT-FAMILY:00093 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:87 ! ACAD8 +relationship: inverse_is_a HGNC:21497 ! ACAD9 +relationship: inverse_is_a HGNC:88 ! ACADL +relationship: inverse_is_a HGNC:89 ! ACADM +relationship: inverse_is_a HGNC:90 ! ACADS +relationship: inverse_is_a HGNC:92 ! ACADVL +relationship: inverse_is_a HGNC:21597 ! ACAD10 +relationship: inverse_is_a HGNC:30211 ! ACAD11 +relationship: inverse_is_a HGNC:91 ! ACADSB +relationship: inverse_is_a HGNC:4189 ! GCDH +relationship: inverse_is_a HGNC:6186 ! IVD + +[Term] +id: FPLX:000005 +name: ACC +synonym: "ACC" EXACT [] +synonym: "ACCs" EXACT [] +synonym: "Acetyl Coenzyme A Carboxylase" EXACT [] +synonym: "Acetyl-CoA carboxylase" EXACT [] +synonym: "acetyl-CoA carboxylase" EXACT [] +xref: BEL:"Acetyl CoA Carboxylase Complex" +xref: ECCODE:6.4.1.2 +xref: IP:IPR013537 +xref: RE:R-HSA-200563 +is_a: FPLX:000000 ! famplex +relationship: has_part HGNC:84 ! ACACA +relationship: has_part HGNC:85 ! ACACB + +[Term] +id: FPLX:000006 +name: Acetyl-CoA-synthetase +synonym: "Acetate-CoA ligase" EXACT [] +synonym: "acetyl CoA ligase" EXACT [] +synonym: "acetyl CoA synthase" EXACT [] +synonym: "Acetyl-CoA synthetase" EXACT [] +synonym: "acetyl-CoA synthetase" EXACT [] +synonym: "acetyl-coenzyme A synthase" EXACT [] +synonym: "ACS" EXACT [] +xref: BEL:"Acetyl-CoA Synthetase Family" +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:10996 ! SLC27A2 +relationship: inverse_is_a HGNC:3569 ! ACSL1 +relationship: inverse_is_a HGNC:3570 ! ACSL3 +relationship: inverse_is_a HGNC:3571 ! ACSL4 +relationship: inverse_is_a HGNC:16526 ! ACSL5 +relationship: inverse_is_a HGNC:16496 ! ACSL6 + +[Term] +id: FPLX:000007 +name: ACOX +synonym: "Acyl-CoA Oxidase" EXACT [] +synonym: "acyl-CoA oxidases" EXACT [] +xref: BEL:"ACOX Family" +xref: IP:IPR002655 +xref: XFAM:PF01756 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:119 ! ACOX1 +relationship: inverse_is_a HGNC:120 ! ACOX2 +relationship: inverse_is_a HGNC:121 ! ACOX3 +relationship: inverse_is_a HGNC:25621 ! ACOXL + +[Term] +id: FPLX:000008 +name: ACSL +synonym: "Acsl" EXACT [] +synonym: "long-chain acyl-CoA synthetase" EXACT [] +xref: BEL:"ACSL Family" +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:3569 ! ACSL1 +relationship: inverse_is_a HGNC:3570 ! ACSL3 +relationship: inverse_is_a HGNC:3571 ! ACSL4 +relationship: inverse_is_a HGNC:16526 ! ACSL5 +relationship: inverse_is_a HGNC:16496 ! ACSL6 + +[Term] +id: FPLX:000009 +name: Actin +synonym: "actin filament" EXACT [] +synonym: "actin" EXACT [] +synonym: "actins" EXACT [] +xref: BEL:"ACT Family" +xref: GO:0005884 +xref: IP:IPR004000 +xref: MEDSCAN:urn:agi-protfc:actins +xref: MESH:D000199 +xref: NCIT:C16258 +xref: NEXTPROT-FAMILY:00078 +xref: XFAM:PF00022 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:129 ! ACTA1 +relationship: inverse_is_a HGNC:130 ! ACTA2 +relationship: inverse_is_a HGNC:132 ! ACTB +relationship: inverse_is_a HGNC:143 ! ACTC1 +relationship: inverse_is_a HGNC:144 ! ACTG1 +relationship: inverse_is_a HGNC:145 ! ACTG2 +relationship: inverse_is_a FPLX:000178 ! F_actin + +[Term] +id: FPLX:000010 +name: Activin +synonym: "activin protein" EXACT [] +synonym: "Activin" EXACT [] +synonym: "activin" EXACT [] +synonym: "activins" EXACT [] +xref: GO:0048180 +xref: NCIT:C20456 +xref: RE:R-HSA-2470478 +xref: RE:R-HSA-2470491 +xref: RE:R-HSA-2470494 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a FPLX:000011 ! Activin_A +relationship: inverse_is_a FPLX:000012 ! Activin_AB +relationship: inverse_is_a FPLX:000013 ! Activin_B + +[Term] +id: FPLX:000011 +name: Activin-A +synonym: "Activin A protein" EXACT [] +synonym: "Activin A" EXACT [] +synonym: "activin A" EXACT [] +synonym: "activin-A" EXACT [] +synonym: "activinA" EXACT [] +xref: GO:0043509 +xref: IP:IPR000491 +xref: RE:R-HSA-206893 +is_a: FPLX:000010 ! Activin +relationship: has_part HGNC:6066 ! INHBA + +[Term] +id: FPLX:000012 +name: Activin-AB +synonym: "activin AB" EXACT [] +xref: RE:R-HSA-1449698 +xref: RE:R-HSA-2470478 +xref: RE:R-HSA-2470491 +xref: RE:R-HSA-2470494 +is_a: FPLX:000010 ! Activin +relationship: has_part HGNC:6066 ! INHBA +relationship: has_part HGNC:6067 ! INHBB + +[Term] +id: FPLX:000013 +name: Activin-B +synonym: "activin-B" EXACT [] +xref: IP:IPR000381 +xref: RE:R-HSA-1449672 +is_a: FPLX:000010 ! Activin +relationship: has_part HGNC:6067 ! INHBB + +[Term] +id: FPLX:000014 +name: ACTN +synonym: "actinin" EXACT [] +xref: BEL:"ACTN Family" +xref: RE:R-HSA-451402 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:163 ! ACTN1 +relationship: inverse_is_a HGNC:164 ! ACTN2 +relationship: inverse_is_a HGNC:165 ! ACTN3 +relationship: inverse_is_a HGNC:166 ! ACTN4 + +[Term] +id: FPLX:000015 +name: Adaptor-protein-II +synonym: "Adaptor Protein 2 complex" EXACT [] +synonym: "adaptor protein complex 2" EXACT [] +synonym: "AP-2 adaptor complex" EXACT [] +synonym: "AP-2 complex" EXACT [] +synonym: "AP-2" EXACT [] +synonym: "AP2 adaptor complex" EXACT [] +synonym: "AP2 clathrin adaptor complex" EXACT [] +synonym: "AP2 complex" EXACT [] +synonym: "AP2" EXACT [] +xref: BEL:"Adaptor Protein II Complex" +xref: GO:0030122 +is_a: FPLX:000000 ! famplex +relationship: has_part HGNC:563 ! AP2B1 +relationship: has_part HGNC:564 ! AP2M1 +relationship: has_part HGNC:565 ! AP2S1 +relationship: has_part FPLX:000049 ! AP2A + +[Term] +id: FPLX:000016 +name: Adaptor-protein-III +synonym: "adaptor protein complex 3" EXACT [] +synonym: "AP-3" EXACT [] +synonym: "AP3" EXACT [] +xref: BEL:"Adaptor Protein III Complex" +is_a: FPLX:000000 ! famplex +relationship: has_part HGNC:566 ! AP3B1 +relationship: has_part HGNC:568 ! AP3D1 +relationship: has_part HGNC:2013 ! AP3S1 +relationship: has_part HGNC:571 ! AP3S2 + +[Term] +id: FPLX:000017 +name: ADCY +synonym: "adenylate cyclase" EXACT [] +synonym: "adenylyl cyclase" EXACT [] +xref: BEL:"ADCY Family" +xref: NCIT:C16264 +xref: RE:R-HSA-5610577 +xref: RE:R-HSA-5610578 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:232 ! ADCY1 +relationship: inverse_is_a HGNC:233 ! ADCY2 +relationship: inverse_is_a HGNC:234 ! ADCY3 +relationship: inverse_is_a HGNC:235 ! ADCY4 +relationship: inverse_is_a HGNC:236 ! ADCY5 +relationship: inverse_is_a HGNC:237 ! ADCY6 +relationship: inverse_is_a HGNC:238 ! ADCY7 +relationship: inverse_is_a HGNC:239 ! ADCY8 +relationship: inverse_is_a HGNC:240 ! ADCY9 +relationship: inverse_is_a HGNC:21285 ! ADCY10 + +[Term] +id: FPLX:000018 +name: ADH +synonym: "alcohol dehydrogenase" EXACT [] +xref: BEL:"ADH Family" +xref: ECCODE:1.1.1.1 +xref: NCIT:C16272 +xref: XFAM:PF00465 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:249 ! ADH1A +relationship: inverse_is_a HGNC:250 ! ADH1B +relationship: inverse_is_a HGNC:251 ! ADH1C +relationship: inverse_is_a HGNC:252 ! ADH4 +relationship: inverse_is_a HGNC:253 ! ADH5 +relationship: inverse_is_a HGNC:255 ! ADH6 +relationship: inverse_is_a HGNC:256 ! ADH7 +relationship: inverse_is_a HGNC:16354 ! ADHFE1 + +[Term] +id: FPLX:000019 +name: ADRA +synonym: "a-adrenoreceptor" EXACT [] +synonym: "alpha adrenoceptor" EXACT [] +synonym: "alpha-adrenergic receptor" EXACT [] +synonym: "alpha-adrenoreceptor" EXACT [] +synonym: "alpha-adrenoreceptors" EXACT [] +synonym: "alpha1 adrenoceptor" EXACT [] +synonym: "α-adrenergic receptor" EXACT [] +synonym: "α-adrenoreceptor" EXACT [] +synonym: "α-adrenoreceptors" EXACT [] +xref: BEL:"ADRA Family" +xref: GO:0004936 +xref: GO:0004937 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:277 ! ADRA1A +relationship: inverse_is_a HGNC:278 ! ADRA1B +relationship: inverse_is_a HGNC:280 ! ADRA1D +relationship: inverse_is_a HGNC:281 ! ADRA2A +relationship: inverse_is_a HGNC:282 ! ADRA2B +relationship: inverse_is_a HGNC:283 ! ADRA2C + +[Term] +id: FPLX:000020 +name: ADRA2 +synonym: "alpha(2)-adrenoceptors" EXACT [] +synonym: "alpha(2)-ARs" EXACT [] +synonym: "alpha2 adrenoceptor" EXACT [] +synonym: "alpha2-AR" EXACT [] +synonym: "ofalpha(2)-adrenoceptor" EXACT [] +synonym: "ofα(2)-adrenoceptor" EXACT [] +synonym: "α(2)-adrenoceptors" EXACT [] +synonym: "α(2)-ARs" EXACT [] +synonym: "α2-AR" EXACT [] +xref: BEL:"ADRA2 Family" +xref: GO:0004938 +xref: RE:R-HSA-390664 +xref: RE:R-HSA-390700 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:281 ! ADRA2A +relationship: inverse_is_a HGNC:282 ! ADRA2B +relationship: inverse_is_a HGNC:283 ! ADRA2C + +[Term] +id: FPLX:000021 +name: ADRB +synonym: "b-adrenergic receptor" EXACT [] +synonym: "b-receptors" EXACT [] +synonym: "beta-adrenergic receptor" EXACT [] +synonym: "beta-adrenoreceptor" EXACT [] +synonym: "betaAR" EXACT [] +synonym: "β-adrenergic receptor" EXACT [] +synonym: "β-adrenoreceptor" EXACT [] +synonym: "βAR" EXACT [] +xref: BEL:"ADRB Family" +xref: NCIT:C17062 +xref: RE:R-HSA-390643 +xref: RE:R-HSA-390670 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:285 ! ADRB1 +relationship: inverse_is_a HGNC:286 ! ADRB2 +relationship: inverse_is_a HGNC:288 ! ADRB3 + +[Term] +id: FPLX:000022 +name: ADRBK +synonym: "BARK" EXACT [] +synonym: "beta adrenergic receptor kinase" EXACT [] +synonym: "betaARK" EXACT [] +synonym: "β adrenergic receptor kinase" EXACT [] +synonym: "βARK" EXACT [] +xref: BEL:"ADRBK Family" +xref: RE:R-HSA-8866229 +is_a: FPLX:000192 ! GRK +relationship: inverse_is_a HGNC:289 ! GRK2 +relationship: inverse_is_a HGNC:290 ! GRK3 + +[Term] +id: FPLX:000023 +name: AKT +synonym: "AKT family" EXACT [] +synonym: "AKT" EXACT [] +synonym: "Akt" EXACT [] +synonym: "PKB" EXACT [] +synonym: "PKB-Akt" EXACT [] +synonym: "PKB/Akt" EXACT [] +xref: BEL:"AKT Family" +xref: MEDSCAN:urn:agi-aopfc:0000439 +xref: NCIT:C41625 +xref: RE:R-HSA-202052 +xref: RE:R-HSA-202072 +xref: RE:R-HSA-202074 +xref: RE:R-HSA-202088 +xref: RE:R-HSA-2317310 +xref: RE:R-HSA-2317317 +xref: RE:R-HSA-2317329 +xref: RE:R-HSA-2400006 +xref: RE:R-HSA-2400013 +xref: SIGNOR:SIGNOR-PF24 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:391 ! AKT1 +relationship: inverse_is_a HGNC:392 ! AKT2 +relationship: inverse_is_a HGNC:393 ! AKT3 + +[Term] +id: FPLX:000024 +name: ALDH +synonym: "aldehyde dehydrogenase (NAD+)" EXACT [] +synonym: "Aldehyde dehydrogenase" EXACT [] +synonym: "aldehyde dehydrogenase" EXACT [] +synonym: "ALDH" EXACT [] +xref: BEL:"ALDH Family" +xref: ECCODE:1.2.1.3 +xref: NCIT:C118481 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:402 ! ALDH1A1 +relationship: inverse_is_a HGNC:15472 ! ALDH1A2 +relationship: inverse_is_a HGNC:409 ! ALDH1A3 +relationship: inverse_is_a HGNC:404 ! ALDH2 +relationship: inverse_is_a HGNC:405 ! ALDH3A1 +relationship: inverse_is_a HGNC:403 ! ALDH3A2 +relationship: inverse_is_a HGNC:410 ! ALDH3B1 +relationship: inverse_is_a HGNC:408 ! ALDH5A1 +relationship: inverse_is_a HGNC:877 ! ALDH7A1 +relationship: inverse_is_a HGNC:412 ! ALDH9A1 + +[Term] +id: FPLX:000025 +name: ALDO +synonym: "ALDO" EXACT [] +synonym: "fructose-bisphosphate aldolase" EXACT [] +xref: BEL:"ALDO Family" +xref: ECCODE:4.1.2.13 +xref: IP:IPR000741 +xref: IP:IPR029768 +xref: RE:R-HSA-179508 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:414 ! ALDOA +relationship: inverse_is_a HGNC:417 ! ALDOB +relationship: inverse_is_a HGNC:418 ! ALDOC + +[Term] +id: FPLX:000026 +name: ALG10 +synonym: "ALG10" EXACT [] +synonym: "Alpha-1,2-glucosyltransferase" EXACT [] +synonym: "Alpha-1,2-glucosyltransferases" EXACT [] +synonym: "alpha-1,2-glucosyltransferase" EXACT [] +synonym: "alpha-1,2-glucosyltransferases" EXACT [] +is_a: FPLX:000198 ! Glycosyltransferase +relationship: inverse_is_a HGNC:23162 ! ALG10 +relationship: inverse_is_a HGNC:31088 ! ALG10B + +[Term] +id: FPLX:000027 +name: ALG1-family +is_a: FPLX:000198 ! Glycosyltransferase +relationship: inverse_is_a HGNC:18294 ! ALG1 +relationship: inverse_is_a HGNC:33721 ! ALG1L +relationship: inverse_is_a HGNC:37258 ! ALG1L2 +relationship: inverse_is_a HGNC:23159 ! ALG2 +relationship: inverse_is_a HGNC:32456 ! ALG11 +relationship: inverse_is_a HGNC:26483 ! GLT1D1 +relationship: inverse_is_a HGNC:20887 ! GTDC1 +relationship: inverse_is_a HGNC:4706 ! GYS1 +relationship: inverse_is_a HGNC:4707 ! GYS2 +relationship: inverse_is_a HGNC:8957 ! PIGA + +[Term] +id: FPLX:000028 +name: ALG3-family +is_a: FPLX:000198 ! Glycosyltransferase +relationship: inverse_is_a HGNC:23056 ! ALG3 +relationship: inverse_is_a HGNC:15672 ! ALG9 +relationship: inverse_is_a HGNC:19358 ! ALG12 +relationship: inverse_is_a HGNC:8959 ! PIGB +relationship: inverse_is_a HGNC:18858 ! PIGM +relationship: inverse_is_a HGNC:26031 ! PIGV +relationship: inverse_is_a HGNC:30596 ! PIGZ +relationship: inverse_is_a HGNC:9202 ! POMT1 +relationship: inverse_is_a HGNC:19743 ! POMT2 + +[Term] +id: FPLX:000029 +name: ALG6-family +synonym: "Alpha-1,3-glucosyltransferase" EXACT [] +synonym: "Alpha-1,3-glucosyltransferases" EXACT [] +synonym: "alpha-1,3-glucosyltransferase" EXACT [] +synonym: "alpha-1,3-glucosyltransferases" EXACT [] +synonym: "Alpha-1,4-glucosyltransferase" EXACT [] +synonym: "Alpha-1,4-glucosyltransferases" EXACT [] +synonym: "alpha-1,4-glucosyltransferase" EXACT [] +synonym: "alpha-1,4-glucosyltransferases" EXACT [] +is_a: FPLX:000198 ! Glycosyltransferase +relationship: inverse_is_a HGNC:23157 ! ALG6 +relationship: inverse_is_a HGNC:23161 ! ALG8 + +[Term] +id: FPLX:000030 +name: ALG13-family +is_a: FPLX:000198 ! Glycosyltransferase +relationship: inverse_is_a HGNC:30881 ! ALG13 +relationship: inverse_is_a HGNC:28287 ! ALG14 + +[Term] +id: FPLX:000031 +name: AMPK +synonym: "AMPK" EXACT [] +xref: BEL:"AMP Activated Protein Kinase Complex" +xref: ECCODE:2.7.11.31 +xref: MEDSCAN:urn:agi-protfc:AMPK +xref: NCIT:C94701 +xref: NEXTPROT-FAMILY:03071 +xref: RE:R-HSA-380931 +xref: RE:R-HSA-380934 +xref: RE:R-HSA-380961 +xref: RE:R-HSA-6805467 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a FPLX:000032 ! AMPK_A1B1G1 +relationship: inverse_is_a FPLX:000033 ! AMPK_A1B1G2 +relationship: inverse_is_a FPLX:000034 ! AMPK_A1B1G3 +relationship: inverse_is_a FPLX:000035 ! AMPK_A1B2G1 +relationship: inverse_is_a FPLX:000036 ! AMPK_A1B2G2 +relationship: inverse_is_a FPLX:000037 ! AMPK_A1B2G3 +relationship: inverse_is_a FPLX:000038 ! AMPK_A2B1G1 +relationship: inverse_is_a FPLX:000039 ! AMPK_A2B1G2 +relationship: inverse_is_a FPLX:000040 ! AMPK_A2B1G3 +relationship: inverse_is_a FPLX:000041 ! AMPK_A2B2G1 +relationship: inverse_is_a FPLX:000042 ! AMPK_A2B2G2 +relationship: inverse_is_a FPLX:000043 ! AMPK_A2B2G3 +relationship: has_part FPLX:000044 ! AMPK_alpha +relationship: has_part FPLX:000045 ! AMPK_beta +relationship: has_part FPLX:000046 ! AMPK_gamma + +[Term] +id: FPLX:000032 +name: AMPK-A1B1G1 +synonym: "AMPK (alpha 1, beta 1, gamma 1)" EXACT [] +synonym: "AMPK (α 1, β 1, γ 1)" EXACT [] +synonym: "alpha1beta1gamma1" EXACT [] +synonym: "AMPK (A1/B1/G1)" EXACT [] +synonym: "AMPK a1b1g1" EXACT [] +synonym: "AMPK alpha1beta1gamma1" EXACT [] +synonym: "AMPK α1β1γ1" EXACT [] +synonym: "α1β1γ1" EXACT [] +is_a: FPLX:000031 ! AMPK +relationship: has_part HGNC:9376 ! PRKAA1 +relationship: has_part HGNC:9378 ! PRKAB1 +relationship: has_part HGNC:9385 ! PRKAG1 + +[Term] +id: FPLX:000033 +name: AMPK-A1B1G2 +synonym: "AMPK (alpha 1, beta 1, gamma 2)" EXACT [] +synonym: "AMPK (α 1, β 1, γ 2)" EXACT [] +synonym: "alpha1beta1gamma2" EXACT [] +synonym: "AMPK (A1/B1/G2)" EXACT [] +synonym: "AMPK a1b1g2" EXACT [] +synonym: "AMPK alpha1beta1gamma2" EXACT [] +synonym: "AMPK α1β1γ2" EXACT [] +synonym: "α1β1γ2" EXACT [] +is_a: FPLX:000031 ! AMPK +relationship: has_part HGNC:9376 ! PRKAA1 +relationship: has_part HGNC:9378 ! PRKAB1 +relationship: has_part HGNC:9386 ! PRKAG2 + +[Term] +id: FPLX:000034 +name: AMPK-A1B1G3 +synonym: "AMPK (alpha 1, beta 1, gamma 3)" EXACT [] +synonym: "AMPK (α 1, β 1, γ 3)" EXACT [] +synonym: "alpha1beta1gamma3" EXACT [] +synonym: "AMPK (A1/B1/G3)" EXACT [] +synonym: "AMPK a1b1g3" EXACT [] +synonym: "AMPK alpha1beta1gamma3" EXACT [] +synonym: "AMPK α1β1γ3" EXACT [] +synonym: "α1β1γ3" EXACT [] +is_a: FPLX:000031 ! AMPK +relationship: has_part HGNC:9376 ! PRKAA1 +relationship: has_part HGNC:9378 ! PRKAB1 +relationship: has_part HGNC:9387 ! PRKAG3 + +[Term] +id: FPLX:000035 +name: AMPK-A1B2G1 +synonym: "AMPK (alpha 1, beta 2, gamma 1)" EXACT [] +synonym: "AMPK (α 1, β 2, γ 1)" EXACT [] +synonym: "alpha1beta2gamma1" EXACT [] +synonym: "AMPK (A1/B2/G1)" EXACT [] +synonym: "AMPK a1b2g1" EXACT [] +synonym: "AMPK alpha1beta2gamma1" EXACT [] +synonym: "AMPK α1β2γ1" EXACT [] +synonym: "α1β2γ1" EXACT [] +is_a: FPLX:000031 ! AMPK +relationship: has_part HGNC:9376 ! PRKAA1 +relationship: has_part HGNC:9379 ! PRKAB2 +relationship: has_part HGNC:9385 ! PRKAG1 + +[Term] +id: FPLX:000036 +name: AMPK-A1B2G2 +synonym: "AMPK (alpha 1, beta 2, gamma 2)" EXACT [] +synonym: "AMPK (α 1, β 2, γ 2)" EXACT [] +synonym: "alpha1beta2gamma2" EXACT [] +synonym: "AMPK (A1/B2/G2)" EXACT [] +synonym: "AMPK a1b2g2" EXACT [] +synonym: "AMPK alpha1beta2gamma2" EXACT [] +synonym: "AMPK α1β2γ2" EXACT [] +synonym: "α1β2γ2" EXACT [] +is_a: FPLX:000031 ! AMPK +relationship: has_part HGNC:9376 ! PRKAA1 +relationship: has_part HGNC:9379 ! PRKAB2 +relationship: has_part HGNC:9386 ! PRKAG2 + +[Term] +id: FPLX:000037 +name: AMPK-A1B2G3 +synonym: "AMPK (alpha 1, beta 2, gamma 3)" EXACT [] +synonym: "AMPK (α 1, β 2, γ 3)" EXACT [] +synonym: "AMPK (A1/B2/G3)" EXACT [] +synonym: "AMPK alpha1beta2gamma3" EXACT [] +synonym: "AMPK α1β2γ3" EXACT [] +is_a: FPLX:000031 ! AMPK +relationship: has_part HGNC:9376 ! PRKAA1 +relationship: has_part HGNC:9379 ! PRKAB2 +relationship: has_part HGNC:9387 ! PRKAG3 + +[Term] +id: FPLX:000038 +name: AMPK-A2B1G1 +synonym: "AMPK (alpha 2, beta 1, gamma 1)" EXACT [] +synonym: "AMPK (α 2, β 1, γ 1)" EXACT [] +synonym: "alpha2beta1gamma1" EXACT [] +synonym: "AMPK (A2/B1/G1)" EXACT [] +synonym: "AMPK a2b1g1" EXACT [] +synonym: "AMPK alpha2beta1gamma1" EXACT [] +synonym: "AMPK α2β1γ1" EXACT [] +synonym: "α2β1γ1" EXACT [] +is_a: FPLX:000031 ! AMPK +relationship: has_part HGNC:9377 ! PRKAA2 +relationship: has_part HGNC:9378 ! PRKAB1 +relationship: has_part HGNC:9385 ! PRKAG1 + +[Term] +id: FPLX:000039 +name: AMPK-A2B1G2 +synonym: "AMPK (alpha 2, beta 1, gamma 2)" EXACT [] +synonym: "AMPK (α 2, β 1, γ 2)" EXACT [] +synonym: "AMPK (A2/B1/G2)" EXACT [] +synonym: "AMPK alpha2beta1gamma2" EXACT [] +synonym: "AMPK α2β1γ2" EXACT [] +is_a: FPLX:000031 ! AMPK +relationship: has_part HGNC:9377 ! PRKAA2 +relationship: has_part HGNC:9378 ! PRKAB1 +relationship: has_part HGNC:9386 ! PRKAG2 + +[Term] +id: FPLX:000040 +name: AMPK-A2B1G3 +synonym: "AMPK (alpha 2, beta 1, gamma 3)" EXACT [] +synonym: "AMPK (α 2, β 1, γ 3)" EXACT [] +synonym: "AMPK (A2/B1/G3)" EXACT [] +synonym: "AMPK alpha2beta1gamma3" EXACT [] +synonym: "AMPK α2β1γ3" EXACT [] +is_a: FPLX:000031 ! AMPK +relationship: has_part HGNC:9377 ! PRKAA2 +relationship: has_part HGNC:9378 ! PRKAB1 +relationship: has_part HGNC:9387 ! PRKAG3 + +[Term] +id: FPLX:000041 +name: AMPK-A2B2G1 +synonym: "AMPK (alpha 2, beta 2, gamma 1)" EXACT [] +synonym: "AMPK (α 2, β 2, γ 1)" EXACT [] +synonym: "alpha2beta2gamma1" EXACT [] +synonym: "AMPK (A2/B2/G1)" EXACT [] +synonym: "AMPK a2b2g1" EXACT [] +synonym: "AMPK alpha2beta2gamma1" EXACT [] +synonym: "AMPK α2β2γ1" EXACT [] +synonym: "α2β2γ1" EXACT [] +is_a: FPLX:000031 ! AMPK +relationship: has_part HGNC:9377 ! PRKAA2 +relationship: has_part HGNC:9379 ! PRKAB2 +relationship: has_part HGNC:9385 ! PRKAG1 + +[Term] +id: FPLX:000042 +name: AMPK-A2B2G2 +synonym: "AMPK (alpha 2, beta 2, gamma 2)" EXACT [] +synonym: "AMPK (α 2, β 2, γ 2)" EXACT [] +synonym: "alpha2beta2gamma2" EXACT [] +synonym: "AMPK (A2/B2/G2)" EXACT [] +synonym: "AMPK a2b2g2" EXACT [] +synonym: "AMPK alpha2beta2gamma2" EXACT [] +synonym: "AMPK α2β2γ2" EXACT [] +synonym: "α2β2γ2" EXACT [] +xref: RE:R-HSA-163679 +xref: RE:R-HSA-163736 +xref: RE:R-HSA-163747 +xref: RE:R-HSA-200408 +is_a: FPLX:000031 ! AMPK +relationship: has_part HGNC:9377 ! PRKAA2 +relationship: has_part HGNC:9379 ! PRKAB2 +relationship: has_part HGNC:9386 ! PRKAG2 + +[Term] +id: FPLX:000043 +name: AMPK-A2B2G3 +synonym: "AMPK (alpha 2, beta 2, gamma 3)" EXACT [] +synonym: "AMPK (α 2, β 2, γ 3)" EXACT [] +synonym: "alpha2beta2gamma3" EXACT [] +synonym: "AMPK (A2/B2/G3)" EXACT [] +synonym: "AMPK a2b2g3" EXACT [] +synonym: "AMPK alpha2beta2gamma3" EXACT [] +synonym: "AMPK α2β2γ3" EXACT [] +synonym: "α2β2γ3" EXACT [] +is_a: FPLX:000031 ! AMPK +relationship: has_part HGNC:9377 ! PRKAA2 +relationship: has_part HGNC:9379 ! PRKAB2 +relationship: has_part HGNC:9387 ! PRKAG3 + +[Term] +id: FPLX:000044 +name: AMPK-alpha +synonym: "AMPKalpha" EXACT [] +synonym: "AMPKα" EXACT [] +synonym: "PRKAA" EXACT [] +xref: BEL:"PRKAA Family" +xref: IP:IPR032270 +xref: NCIT:C116019 +xref: RE:R-HSA-2151213 +xref: RE:R-HSA-381844 +xref: RE:R-HSA-381845 +xref: SIGNOR:SIGNOR-PF6 +relationship: part_of FPLX:000031 ! AMPK +relationship: inverse_is_a HGNC:9376 ! PRKAA1 +relationship: inverse_is_a HGNC:9377 ! PRKAA2 + +[Term] +id: FPLX:000045 +name: AMPK-beta +synonym: "PRKAB" EXACT [] +xref: BEL:"PRKAB Family" +xref: IP:IPR006828 +xref: IP:IPR032640 +xref: RE:R-HSA-2151208 +xref: RE:R-HSA-381854 +relationship: part_of FPLX:000031 ! AMPK +relationship: inverse_is_a HGNC:9378 ! PRKAB1 +relationship: inverse_is_a HGNC:9379 ! PRKAB2 + +[Term] +id: FPLX:000046 +name: AMPK-gamma +synonym: "PRKAG" EXACT [] +xref: BEL:"PRKAG Family" +xref: RE:R-HSA-2151212 +xref: RE:R-HSA-2316451 +xref: RE:R-HSA-381851 +relationship: part_of FPLX:000031 ! AMPK +relationship: inverse_is_a HGNC:9385 ! PRKAG1 +relationship: inverse_is_a HGNC:9386 ! PRKAG2 +relationship: inverse_is_a HGNC:9387 ! PRKAG3 + +[Term] +id: FPLX:000047 +name: Annexin-II-heterotetramer +synonym: "A2t" EXACT [] +synonym: "annexin A2 heterotetramer" EXACT [] +synonym: "annexin II heterotetramer" EXACT [] +synonym: "ANXA2 heterotetramer" EXACT [] +xref: BEL:"Annexin II Heterotetramer Complex" +xref: RE:R-HSA-5336141 +is_a: FPLX:000000 ! famplex +relationship: has_part HGNC:537 ! ANXA2 +relationship: has_part HGNC:10487 ! S100A10 + +[Term] +id: FPLX:000048 +name: AP1 +synonym: "AP-1" EXACT [] +synonym: "AP1" EXACT [] +xref: BEL:"AP-1 Complex" +xref: MESH:D018808 +xref: NCIT:C17450 +is_a: FPLX:000000 ! famplex +relationship: has_part FPLX:000173 ! FOS_family +relationship: has_part FPLX:000268 ! JUN_family + +[Term] +id: FPLX:000049 +name: AP2A +xref: IP:IPR017104 +relationship: part_of FPLX:000015 ! Adaptor_protein_II +relationship: inverse_is_a HGNC:561 ! AP2A1 +relationship: inverse_is_a HGNC:562 ! AP2A2 + +[Term] +id: FPLX:000050 +name: APC-C +synonym: "APC/C" EXACT [] +xref: GO:0005680 +xref: MEDSCAN:urn:agi-aopfc:0000571 +xref: MEDSCAN:urn:agi-complex:prophash-dd63d0a558770b12c9149b4955828f35 +is_a: FPLX:000000 ! famplex +relationship: has_part HGNC:19989 ! ANAPC2 +relationship: has_part HGNC:14452 ! ANAPC11 +relationship: has_part HGNC:19988 ! ANAPC1 +relationship: has_part HGNC:1720 ! CDC16 +relationship: has_part HGNC:1728 ! CDC27 +relationship: has_part HGNC:1724 ! CDC23 +relationship: has_part HGNC:15713 ! ANAPC5 +relationship: has_part HGNC:24077 ! ANAPC10 +relationship: has_part HGNC:24531 ! ANAPC15 +relationship: has_part HGNC:24540 ! ANAPC13 +relationship: has_part HGNC:17839 ! CDC26 +relationship: has_part HGNC:26976 ! ANAPC16 +relationship: has_part HGNC:17380 ! ANAPC7 +relationship: has_part HGNC:19990 ! ANAPC4 + +[Term] +id: FPLX:000051 +name: APOA +synonym: "ApoA" EXACT [] +synonym: "apoA" EXACT [] +synonym: "apolipoprotein (a)" EXACT [] +synonym: "apolipoprotein A" EXACT [] +synonym: "apolipoprotein(A)" EXACT [] +synonym: "apolipoprotein(a)" EXACT [] +xref: BEL:"APOA Family" +xref: NCIT:C105952 +is_a: FPLX:000052 ! Apolipoprotein +relationship: inverse_is_a HGNC:600 ! APOA1 +relationship: inverse_is_a HGNC:601 ! APOA2 +relationship: inverse_is_a HGNC:602 ! APOA4 +relationship: inverse_is_a HGNC:17288 ! APOA5 + +[Term] +id: FPLX:000052 +name: Apolipoprotein +synonym: "Apolipoprotein" EXACT [] +synonym: "apolipoprotein" EXACT [] +synonym: "apolipoproteins" EXACT [] +xref: IP:IPR000074 +xref: MEDSCAN:urn:agi-protfc:apolipoprotein +xref: XFAM:PF01442 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a FPLX:000051 ! APOA +relationship: inverse_is_a HGNC:613 ! APOE + +[Term] +id: FPLX:000053 +name: ARF-GTPase-family +synonym: "ADP ribosylation factor" EXACT [] +synonym: "ARF" EXACT [] +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:660 ! TRIM23 +relationship: inverse_is_a HGNC:652 ! ARF1 +relationship: inverse_is_a HGNC:654 ! ARF3 +relationship: inverse_is_a HGNC:655 ! ARF4 +relationship: inverse_is_a HGNC:658 ! ARF5 +relationship: inverse_is_a HGNC:659 ! ARF6 +relationship: inverse_is_a HGNC:692 ! ARL1 +relationship: inverse_is_a HGNC:693 ! ARL2 +relationship: inverse_is_a HGNC:694 ! ARL3 +relationship: inverse_is_a HGNC:695 ! ARL4A +relationship: inverse_is_a HGNC:698 ! ARL4C +relationship: inverse_is_a HGNC:656 ! ARL4D +relationship: inverse_is_a HGNC:696 ! ARL5A +relationship: inverse_is_a HGNC:23052 ! ARL5B +relationship: inverse_is_a HGNC:31111 ! ARL5C +relationship: inverse_is_a HGNC:13210 ! ARL6 +relationship: inverse_is_a HGNC:25192 ! ARL8A +relationship: inverse_is_a HGNC:25564 ! ARL8B +relationship: inverse_is_a HGNC:23592 ! ARL9 +relationship: inverse_is_a HGNC:22042 ! ARL10 +relationship: inverse_is_a HGNC:24046 ! ARL11 +relationship: inverse_is_a HGNC:31709 ! ARL13A +relationship: inverse_is_a HGNC:25419 ! ARL13B +relationship: inverse_is_a HGNC:22974 ! ARL14 +relationship: inverse_is_a HGNC:25945 ! ARL15 +relationship: inverse_is_a HGNC:27902 ! ARL16 +relationship: inverse_is_a HGNC:24096 ! ARL17A +relationship: inverse_is_a HGNC:32387 ! ARL17B +relationship: inverse_is_a HGNC:662 ! ARFRP1 +relationship: inverse_is_a HGNC:10534 ! SAR1A +relationship: inverse_is_a HGNC:10535 ! SAR1B + +[Term] +id: FPLX:000054 +name: Arp2-3-protein +synonym: "Arp2/3" EXACT [] +xref: BEL:"Arp2/3 Protein Complex" +is_a: FPLX:000000 ! famplex +relationship: has_part HGNC:703 ! ARPC1A +relationship: has_part HGNC:704 ! ARPC1B +relationship: has_part HGNC:705 ! ARPC2 +relationship: has_part HGNC:706 ! ARPC3 +relationship: has_part HGNC:707 ! ARPC4 +relationship: has_part HGNC:708 ! ARPC5 +relationship: has_part HGNC:23366 ! ARPC5L + +[Term] +id: FPLX:000055 +name: ARRB +synonym: "b-arrestin" EXACT [] +synonym: "barrestins" EXACT [] +xref: BEL:"ARRB Family" +xref: RE:R-HSA-1911410 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:711 ! ARRB1 +relationship: inverse_is_a HGNC:712 ! ARRB2 + +[Term] +id: FPLX:000056 +name: ATG4 +synonym: "ATG4" EXACT [] +synonym: "Atg4" EXACT [] +xref: RE:R-HSA-5682664 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:16489 ! ATG4A +relationship: inverse_is_a HGNC:20790 ! ATG4B +relationship: inverse_is_a HGNC:16040 ! ATG4C +relationship: inverse_is_a HGNC:20789 ! ATG4D + +[Term] +id: FPLX:000057 +name: ATP1A +synonym: "ATP1A" EXACT [] +synonym: "ATPase Na+/K+ transporting subunit alpha" EXACT [] +synonym: "ATPase Na+/K+ transporting subunit beta" EXACT [] +synonym: "ATPase Na+/K+ transporting subunit α" EXACT [] +synonym: "ATPase Na+/K+ transporting subunit β" EXACT [] +synonym: "Na/K ATPase alpha" EXACT [] +synonym: "Na/K ATPase α" EXACT [] +xref: RE:R-HSA-936779 +relationship: part_of FPLX:000303 ! Na_K_ATPase +relationship: inverse_is_a HGNC:799 ! ATP1A1 +relationship: inverse_is_a HGNC:800 ! ATP1A2 +relationship: inverse_is_a HGNC:801 ! ATP1A3 +relationship: inverse_is_a HGNC:14073 ! ATP1A4 + +[Term] +id: FPLX:000058 +name: ATP1B +synonym: "Na,K-ATPase beta subunit" EXACT [] +synonym: "Na,K-ATPase β subunit" EXACT [] +synonym: "ATP1B" EXACT [] +xref: RE:R-HSA-936820 +relationship: part_of FPLX:000303 ! Na_K_ATPase +relationship: inverse_is_a HGNC:804 ! ATP1B1 +relationship: inverse_is_a HGNC:805 ! ATP1B2 +relationship: inverse_is_a HGNC:806 ! ATP1B3 +relationship: inverse_is_a HGNC:808 ! ATP1B4 + +[Term] +id: FPLX:000059 +name: ATP5G +synonym: "ATP synthase H + transporting mitochondrial F0 complex subunit G" EXACT [] +xref: BEL:"ATP5G Family" +xref: IP:IPR000454 +xref: IP:IPR020537 +relationship: part_of FPLX:000060 ! ATP_synthase +relationship: inverse_is_a HGNC:841 ! ATP5MC1 +relationship: inverse_is_a HGNC:842 ! ATP5MC2 +relationship: inverse_is_a HGNC:843 ! ATP5MC3 + +[Term] +id: FPLX:000060 +name: ATP-synthase +synonym: "ATP synthase" EXACT [] +xref: BEL:"Proton Transporting ATP Synthase Complex" +is_a: FPLX:000000 ! famplex +relationship: has_part HGNC:823 ! ATP5F1A +relationship: has_part HGNC:830 ! ATP5F1B +relationship: has_part HGNC:833 ! ATP5F1C +relationship: has_part HGNC:837 ! ATP5F1D +relationship: has_part HGNC:838 ! ATP5F1E +relationship: has_part HGNC:30889 ! ATP5MD +relationship: has_part HGNC:846 ! ATP5ME +relationship: has_part HGNC:848 ! ATP5MF +relationship: has_part HGNC:14247 ! ATP5MG +relationship: has_part HGNC:1188 ! ATP5MPL +relationship: has_part HGNC:7414 ! MT-ATP6 +relationship: has_part HGNC:7415 ! MT-ATP8 +relationship: has_part HGNC:840 ! ATP5PB +relationship: has_part HGNC:845 ! ATP5PD +relationship: has_part HGNC:847 ! ATP5PF +relationship: has_part HGNC:850 ! ATP5PO +relationship: has_part HGNC:871 ! ATP5IF1 +relationship: has_part FPLX:000059 ! ATP5G + +[Term] +id: FPLX:000061 +name: Augmin +synonym: "Augmin" EXACT [] +synonym: "HAUS" EXACT [] +synonym: "HAUS complex" EXACT [] +xref: GO:0070652 +xref: HGNC_GROUP:581 +xref: RE:R-HSA-8855211 +is_a: FPLX:000000 ! famplex +relationship: has_part HGNC:25174 ! HAUS1 +relationship: has_part HGNC:25530 ! HAUS2 +relationship: has_part HGNC:28719 ! HAUS3 +relationship: has_part HGNC:20163 ! HAUS4 +relationship: has_part HGNC:29130 ! HAUS5 +relationship: has_part HGNC:25948 ! HAUS6 +relationship: has_part HGNC:32979 ! HAUS7 +relationship: has_part HGNC:30532 ! HAUS8 + +[Term] +id: FPLX:000062 +name: AXIN +synonym: "Axin" EXACT [] +synonym: "hAxin" EXACT [] +xref: BEL:"AXIN Family" +xref: IP:IPR014936 +xref: IP:IPR032101 +xref: RE:R-HSA-3640819 +xref: RE:R-HSA-3640863 +xref: RE:R-HSA-3772502 +xref: RE:R-HSA-4641132 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:903 ! AXIN1 +relationship: inverse_is_a HGNC:904 ! AXIN2 + +[Term] +id: FPLX:000063 +name: B3GAT +synonym: "B3GAT" EXACT [] +synonym: "Beta-1,3-glucuronyltransferase" EXACT [] +synonym: "Beta-1,3-glucuronyltransferases" EXACT [] +synonym: "beta-1,3-glucuronyltransferase" EXACT [] +synonym: "beta-1,3-glucuronyltransferases" EXACT [] +is_a: FPLX:000198 ! Glycosyltransferase +relationship: inverse_is_a HGNC:921 ! B3GAT1 +relationship: inverse_is_a HGNC:922 ! B3GAT2 +relationship: inverse_is_a HGNC:923 ! B3GAT3 + +[Term] +id: FPLX:000064 +name: BCKDC +synonym: "BCKDC" EXACT [] +synonym: "BCKDH" EXACT [] +synonym: "branched-chain alpha-keto acid dehydrogenase complex" EXACT [] +synonym: "branched-chain alpha-ketoacid dehydrogenase complex" EXACT [] +synonym: "branched-chain α-keto acid dehydrogenase complex" EXACT [] +synonym: "branched-chain α-ketoacid dehydrogenase complex" EXACT [] +xref: BEL:"Branched Chain Alpha Keto Acid Dehydrogenase Complex" +xref: RE:R-HSA-5693120 +xref: RE:R-HSA-6792583 +xref: RE:R-HSA-70019 +is_a: FPLX:000000 ! famplex +relationship: has_part HGNC:986 ! BCKDHA +relationship: has_part HGNC:987 ! BCKDHB +relationship: has_part HGNC:2698 ! DBT +relationship: has_part HGNC:2898 ! DLD + +[Term] +id: FPLX:000065 +name: Beta-3-4-GTF +synonym: "Beta 3-glycosyltransferase" EXACT [] +synonym: "Beta 3-glycosyltransferases" EXACT [] +synonym: "beta 3-glycosyltransferase" EXACT [] +synonym: "beta 3-glycosyltransferases" EXACT [] +synonym: "Beta 4-glycosyltransferase" EXACT [] +synonym: "Beta 4-glycosyltransferases" EXACT [] +synonym: "beta 4-glycosyltransferase" EXACT [] +synonym: "beta 4-glycosyltransferases" EXACT [] +is_a: FPLX:000198 ! Glycosyltransferase +relationship: inverse_is_a HGNC:918 ! B3GALNT1 +relationship: inverse_is_a HGNC:28596 ! B3GALNT2 +relationship: inverse_is_a HGNC:20207 ! B3GLCT +relationship: inverse_is_a HGNC:916 ! B3GALT1 +relationship: inverse_is_a HGNC:917 ! B3GALT2 +relationship: inverse_is_a HGNC:919 ! B3GALT4 +relationship: inverse_is_a HGNC:920 ! B3GALT5 +relationship: inverse_is_a HGNC:17978 ! B3GALT6 +relationship: inverse_is_a HGNC:15629 ! B3GNT2 +relationship: inverse_is_a HGNC:13528 ! B3GNT3 +relationship: inverse_is_a HGNC:15683 ! B3GNT4 +relationship: inverse_is_a HGNC:15684 ! B3GNT5 +relationship: inverse_is_a HGNC:24141 ! B3GNT6 +relationship: inverse_is_a HGNC:18811 ! B3GNT7 +relationship: inverse_is_a HGNC:24139 ! B3GNT8 +relationship: inverse_is_a HGNC:28714 ! B3GNT9 +relationship: inverse_is_a HGNC:24291 ! CHPF +relationship: inverse_is_a HGNC:29270 ! CHPF2 +relationship: inverse_is_a HGNC:17198 ! CHSY1 +relationship: inverse_is_a HGNC:24293 ! CHSY3 +relationship: inverse_is_a HGNC:24337 ! C1GALT1 +relationship: inverse_is_a HGNC:6560 ! LFNG +relationship: inverse_is_a HGNC:7038 ! MFNG +relationship: inverse_is_a HGNC:9974 ! RFNG +relationship: inverse_is_a HGNC:4117 ! B4GALNT1 +relationship: inverse_is_a HGNC:24136 ! B4GALNT2 +relationship: inverse_is_a HGNC:24137 ! B4GALNT3 +relationship: inverse_is_a HGNC:26315 ! B4GALNT4 +relationship: inverse_is_a HGNC:924 ! B4GALT1 +relationship: inverse_is_a HGNC:925 ! B4GALT2 +relationship: inverse_is_a HGNC:926 ! B4GALT3 +relationship: inverse_is_a HGNC:927 ! B4GALT4 +relationship: inverse_is_a HGNC:928 ! B4GALT5 +relationship: inverse_is_a HGNC:929 ! B4GALT6 +relationship: inverse_is_a HGNC:930 ! B4GALT7 +relationship: inverse_is_a HGNC:24290 ! CSGALNACT1 +relationship: inverse_is_a HGNC:24292 ! CSGALNACT2 + +[Term] +id: FPLX:000066 +name: BIRC +synonym: "BIRs" EXACT [] +xref: BEL:"BIRC Family" +xref: IP:IPR001370 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:590 ! BIRC2 +relationship: inverse_is_a HGNC:591 ! BIRC3 +relationship: inverse_is_a HGNC:593 ! BIRC5 +relationship: inverse_is_a HGNC:13516 ! BIRC6 +relationship: inverse_is_a HGNC:13702 ! BIRC7 +relationship: inverse_is_a HGNC:14878 ! BIRC8 +relationship: inverse_is_a HGNC:7634 ! NAIP +relationship: inverse_is_a HGNC:592 ! XIAP + +[Term] +id: FPLX:000067 +name: BMP +synonym: "BMP" EXACT [] +xref: BEL:"BMP Family" +xref: NCIT:C17274 +xref: XFAM:PF02608 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:1067 ! BMP1 +relationship: inverse_is_a HGNC:1069 ! BMP2 +relationship: inverse_is_a HGNC:1070 ! BMP3 +relationship: inverse_is_a HGNC:1071 ! BMP4 +relationship: inverse_is_a HGNC:1072 ! BMP5 +relationship: inverse_is_a HGNC:1073 ! BMP6 +relationship: inverse_is_a HGNC:1074 ! BMP7 +relationship: inverse_is_a HGNC:21650 ! BMP8A +relationship: inverse_is_a HGNC:1075 ! BMP8B +relationship: inverse_is_a HGNC:20869 ! BMP10 +relationship: inverse_is_a HGNC:1068 ! BMP15 +relationship: inverse_is_a HGNC:4214 ! GDF1 +relationship: inverse_is_a HGNC:4217 ! GDF2 +relationship: inverse_is_a HGNC:4218 ! GDF3 +relationship: inverse_is_a HGNC:4220 ! GDF5 +relationship: inverse_is_a HGNC:4221 ! GDF6 +relationship: inverse_is_a HGNC:4222 ! GDF7 + +[Term] +id: FPLX:000068 +name: BMP-receptor +xref: SIGNOR:SIGNOR-PF9 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a FPLX:000069 ! BMP_receptor_type_I +relationship: inverse_is_a FPLX:000070 ! BMP_receptor_type_II + +[Term] +id: FPLX:000069 +name: BMP-receptor-type-I +synonym: "BMP Receptor Type I" EXACT [] +synonym: "BMP type I receptor" EXACT [] +synonym: "bone morphogenetic protein I receptor" EXACT [] +synonym: "bone morphogenetic protein receptor 1" EXACT [] +synonym: "bone morphogenetic protein receptor type I" EXACT [] +synonym: "bone morphogenetic protein type I receptors" EXACT [] +synonym: "BRI" EXACT [] +xref: BEL:"BMP Receptor Type I Family" +xref: MEDSCAN:urn:agi-protfc:bone%20morphogenetic%20protein%20I%20receptor +is_a: FPLX:000068 ! BMP_receptor +relationship: inverse_is_a HGNC:171 ! ACVR1 +relationship: inverse_is_a HGNC:1076 ! BMPR1A +relationship: inverse_is_a HGNC:1077 ! BMPR1B + +[Term] +id: FPLX:000070 +name: BMP-receptor-type-II +synonym: "BMP Receptor Type II" EXACT [] +synonym: "BMP type II receptor" EXACT [] +synonym: "bone morphogenetic protein receptor 2" EXACT [] +synonym: "bone morphogenetic protein receptor type II" EXACT [] +synonym: "bone morphogenetic protein type II receptors" EXACT [] +synonym: "BRII" EXACT [] +xref: BEL:"BMP Receptor Type II Family" +xref: RE:R-HSA-201465 +xref: RE:R-HSA-201804 +is_a: FPLX:000068 ! BMP_receptor +relationship: inverse_is_a HGNC:173 ! ACVR2A +relationship: inverse_is_a HGNC:174 ! ACVR2B +relationship: inverse_is_a HGNC:1078 ! BMPR2 + +[Term] +id: FPLX:000071 +name: BRCA +synonym: "BRCA" EXACT [] +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:1100 ! BRCA1 +relationship: inverse_is_a HGNC:1101 ! BRCA2 + +[Term] +id: FPLX:000072 +name: C1 +synonym: "c1 complex" EXACT [] +synonym: "C1" EXACT [] +synonym: "C1-complex" EXACT [] +xref: BEL:"C1 Complex" +xref: RE:R-HSA-173584 +xref: RE:R-HSA-173615 +xref: RE:R-HSA-173617 +is_a: FPLX:000000 ! famplex +relationship: has_part HGNC:1241 ! C1QA +relationship: has_part HGNC:1242 ! C1QB +relationship: has_part HGNC:1245 ! C1QC +relationship: has_part HGNC:1246 ! C1R +relationship: has_part HGNC:1247 ! C1S + +[Term] +id: FPLX:000073 +name: C1q +synonym: "C1q" EXACT [] +xref: BEL:"C1q Complex" +is_a: FPLX:000000 ! famplex +relationship: has_part HGNC:1241 ! C1QA +relationship: has_part HGNC:1242 ! C1QB + +[Term] +id: FPLX:000074 +name: Cadherin +synonym: "cadherin" EXACT [] +xref: BEL:"CDH Family" +xref: MEDSCAN:urn:agi-complex:prophash-8a9e47ee0ee03d8d8b6e029e2fba6896 +xref: MEDSCAN:urn:agi-protfc:cadherin +xref: NCIT:C16373 +xref: XFAM:PF00028 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:1748 ! CDH1 +relationship: inverse_is_a HGNC:1749 ! CDH10 +relationship: inverse_is_a HGNC:1750 ! CDH11 +relationship: inverse_is_a HGNC:1751 ! CDH12 +relationship: inverse_is_a HGNC:1753 ! CDH13 +relationship: inverse_is_a HGNC:1754 ! CDH15 +relationship: inverse_is_a HGNC:1755 ! CDH16 +relationship: inverse_is_a HGNC:1756 ! CDH17 +relationship: inverse_is_a HGNC:1757 ! CDH18 +relationship: inverse_is_a HGNC:1758 ! CDH19 +relationship: inverse_is_a HGNC:1759 ! CDH2 +relationship: inverse_is_a HGNC:1760 ! CDH20 +relationship: inverse_is_a HGNC:13251 ! CDH22 +relationship: inverse_is_a HGNC:14265 ! CDH24 +relationship: inverse_is_a HGNC:1762 ! CDH3 +relationship: inverse_is_a HGNC:1763 ! CDH4 +relationship: inverse_is_a HGNC:1764 ! CDH5 +relationship: inverse_is_a HGNC:1765 ! CDH6 +relationship: inverse_is_a HGNC:1766 ! CDH7 +relationship: inverse_is_a HGNC:1767 ! CDH8 +relationship: inverse_is_a HGNC:1768 ! CDH9 + +[Term] +id: FPLX:000075 +name: CALM +synonym: "Calmodulin" EXACT [] +synonym: "calmodulin" EXACT [] +synonym: "CaM" EXACT [] +xref: BEL:"CALM Family" +xref: MEDSCAN:urn:agi-aopfc:0000452 +xref: MEDSCAN:urn:agi-complex:prophash-f7e292d6e30998b81cf5f772ab430f11 +xref: NCIT:C16375 +xref: NEXTPROT-FAMILY:00440 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:1442 ! CALM1 +relationship: inverse_is_a HGNC:1445 ! CALM2 +relationship: inverse_is_a HGNC:1449 ! CALM3 + +[Term] +id: FPLX:000076 +name: CAMK +synonym: "CaMK family" EXACT [] +synonym: "CaMK" EXACT [] +xref: BEL:"CAMK Family" +xref: ECCODE:2.7.11.17 +xref: NEXTPROT-FAMILY:03072 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:1459 ! CAMK1 +relationship: inverse_is_a HGNC:19341 ! CAMK1D +relationship: inverse_is_a HGNC:14585 ! CAMK1G +relationship: inverse_is_a HGNC:1464 ! CAMK4 +relationship: inverse_is_a FPLX:000078 ! CAMK2_family + +[Term] +id: FPLX:000077 +name: CAMK2-complex +synonym: "Ca(2+)-calmodulin-dependent protein kinase II" EXACT [] +synonym: "Ca(2+)/calmodulin-dependent kinase II" EXACT [] +synonym: "CaM kinase II" EXACT [] +synonym: "CaMK II" EXACT [] +synonym: "CaMKII" EXACT [] +xref: BEL:"CAMK2 Complex" +xref: IP:IPR013543 +xref: MEDSCAN:urn:agi-complex:CaM%20kinase%20II +xref: RE:R-HSA-417004 +xref: RE:R-HSA-432792 +xref: RE:R-HSA-444796 +xref: RE:R-HSA-445374 +is_a: FPLX:000000 ! famplex +relationship: has_part HGNC:1460 ! CAMK2A +relationship: has_part HGNC:1461 ! CAMK2B +relationship: has_part HGNC:1462 ! CAMK2D +relationship: has_part HGNC:1463 ! CAMK2G + +[Term] +id: FPLX:000078 +name: CAMK2-family +synonym: "calmodulindependent kinase II" EXACT [] +synonym: "CAMK2" EXACT [] +synonym: "CaMK2" EXACT [] +synonym: "CAMKII" EXACT [] +xref: BEL:"CAMK2 Family" +xref: IP:IPR013543 +xref: RE:R-HSA-417004 +xref: RE:R-HSA-432792 +xref: RE:R-HSA-444796 +xref: RE:R-HSA-445374 +is_a: FPLX:000076 ! CAMK +relationship: inverse_is_a HGNC:1460 ! CAMK2A +relationship: inverse_is_a HGNC:1461 ! CAMK2B +relationship: inverse_is_a HGNC:1462 ! CAMK2D +relationship: inverse_is_a HGNC:1463 ! CAMK2G + +[Term] +id: FPLX:000079 +name: CAPN +synonym: "calpain" EXACT [] +xref: BEL:"CAPN Family" +xref: GO:0004198 +xref: IP:IPR022684 +xref: NCIT:C16377 +xref: RE:R-HSA-8848649 +xref: RE:R-HSA-8848668 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:1476 ! CAPN1 +relationship: inverse_is_a HGNC:1477 ! CAPN10 +relationship: inverse_is_a HGNC:1478 ! CAPN11 +relationship: inverse_is_a HGNC:13249 ! CAPN12 +relationship: inverse_is_a HGNC:16663 ! CAPN13 +relationship: inverse_is_a HGNC:16664 ! CAPN14 +relationship: inverse_is_a HGNC:1479 ! CAPN2 +relationship: inverse_is_a HGNC:1480 ! CAPN3 +relationship: inverse_is_a HGNC:1482 ! CAPN5 +relationship: inverse_is_a HGNC:1483 ! CAPN6 +relationship: inverse_is_a HGNC:1484 ! CAPN7 +relationship: inverse_is_a HGNC:1486 ! CAPN9 +relationship: inverse_is_a HGNC:11182 ! CAPN15 +relationship: inverse_is_a HGNC:1485 ! CAPN8 + +[Term] +id: FPLX:000080 +name: Carboxylesterase +synonym: "carboxylesterase" EXACT [] +synonym: "carboxylesterases" EXACT [] +xref: BEL:"Carboxylesterase Family" +xref: ECCODE:3.1.1.1 +xref: NCIT:C112051 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:1863 ! CES1 +relationship: inverse_is_a HGNC:1864 ! CES2 +relationship: inverse_is_a HGNC:1865 ! CES3 +relationship: inverse_is_a HGNC:26741 ! CES4A +relationship: inverse_is_a HGNC:26459 ! CES5A + +[Term] +id: FPLX:000081 +name: Caspase +synonym: "caspase" EXACT [] +synonym: "caspases" EXACT [] +xref: BEL:"CASP Family" +xref: GO:0004199 +xref: IP:IPR002138 +xref: IP:IPR033139 +xref: MESH:D020169 +xref: NCIT:C18153 +xref: XFAM:PF00656 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:1499 ! CASP1 +relationship: inverse_is_a HGNC:1503 ! CASP2 +relationship: inverse_is_a HGNC:1505 ! CASP4 +relationship: inverse_is_a HGNC:1506 ! CASP5 +relationship: inverse_is_a HGNC:1507 ! CASP6 +relationship: inverse_is_a HGNC:1509 ! CASP8 +relationship: inverse_is_a HGNC:1511 ! CASP9 +relationship: inverse_is_a HGNC:1500 ! CASP10 +relationship: inverse_is_a HGNC:19004 ! CASP12 +relationship: inverse_is_a HGNC:1502 ! CASP14 +relationship: inverse_is_a FPLX:000082 ! Caspase_3_7 + +[Term] +id: FPLX:000082 +name: Caspase-3-7 +synonym: "caspase-3/7" EXACT [] +xref: RE:R-HSA-202877 +is_a: FPLX:000081 ! Caspase +relationship: inverse_is_a HGNC:1504 ! CASP3 +relationship: inverse_is_a HGNC:1508 ! CASP7 + +[Term] +id: FPLX:000083 +name: CAV +synonym: "Caveolin" EXACT [] +synonym: "caveolin" EXACT [] +xref: BEL:"CAV Family" +xref: IP:IPR001612 +xref: IP:IPR018361 +xref: MEDSCAN:urn:agi-protfc:caveolin +xref: NEXTPROT-FAMILY:00489 +xref: XFAM:PF01146 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:1527 ! CAV1 +relationship: inverse_is_a HGNC:1528 ! CAV2 +relationship: inverse_is_a HGNC:1529 ! CAV3 + +[Term] +id: FPLX:000084 +name: CBF3 +def: "SKP1 (together with SKP2) was identified as an essential component of the cyclin A-CDK2 S phase kinase complex" [interpro:IPR016072] +synonym: "CBF3 complex" EXACT [] +synonym: "CBF3" EXACT [] +synonym: "kinetochore centromere binding factor 3" EXACT [] +xref: BEL:"CBF3 Complex" +xref: GO:0031518 +xref: IP:IPR016072 +xref: IP:IPR016897 +is_a: FPLX:000000 ! famplex +relationship: has_part HGNC:10899 ! SKP1 + +[Term] +id: FPLX:000085 +name: CCT-complex +synonym: "CCT complex" EXACT [] +synonym: "CCT" EXACT [] +synonym: "chaperonin containing TCP-1" EXACT [] +synonym: "chaperonin" EXACT [] +synonym: "chaperonin-containing t-complex polypeptide 1" EXACT [] +synonym: "chaperonin-containing TCP1 complex" EXACT [] +synonym: "TRiC" EXACT [] +xref: BEL:"CCT Complex" +xref: GO:0005832 +xref: IP:IPR002194 +xref: MEDSCAN:urn:agi-complex:prophash-cd6413d79122d5489ee4b4e339245b61 +xref: RE:R-HSA-390455 +xref: RE:R-HSA-390474 +is_a: FPLX:000000 ! famplex +relationship: has_part HGNC:1615 ! CCT2 +relationship: has_part HGNC:1616 ! CCT3 +relationship: has_part HGNC:1617 ! CCT4 +relationship: has_part HGNC:1618 ! CCT5 +relationship: has_part HGNC:1620 ! CCT6A +relationship: has_part HGNC:1621 ! CCT6B +relationship: has_part HGNC:1622 ! CCT7 +relationship: has_part HGNC:1623 ! CCT8 +relationship: has_part HGNC:11655 ! TCP1 + +[Term] +id: FPLX:000086 +name: CD16 +synonym: "CD16" EXACT [] +xref: BEL:"CD16 Family" +xref: NCIT:C17487 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:3619 ! FCGR3A +relationship: inverse_is_a HGNC:3620 ! FCGR3B + +[Term] +id: FPLX:000087 +name: CD3 +synonym: "CD3" EXACT [] +xref: BEL:"CD3 Complex" +xref: MEDSCAN:urn:agi-complex:CD3%20complex +xref: NCIT:C38897 +is_a: FPLX:000000 ! famplex +relationship: has_part HGNC:1677 ! CD247 +relationship: has_part HGNC:1673 ! CD3D +relationship: has_part HGNC:1674 ! CD3E +relationship: has_part HGNC:1675 ! CD3G + +[Term] +id: FPLX:000088 +name: CD32 +synonym: "CD32" EXACT [] +xref: BEL:"CD32 Family" +xref: NCIT:C18308 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:3616 ! FCGR2A +relationship: inverse_is_a HGNC:3618 ! FCGR2B +relationship: inverse_is_a HGNC:15626 ! FCGR2C + +[Term] +id: FPLX:000089 +name: CD64 +synonym: "CD64" EXACT [] +xref: BEL:"CD64 Family" +xref: RE:R-HSA-1031694 +xref: RE:R-HSA-1236898 +xref: RE:R-HSA-1236905 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:3613 ! FCGR1A +relationship: inverse_is_a HGNC:3614 ! FCGR1B + +[Term] +id: FPLX:000090 +name: CD8 +synonym: "CD8" EXACT [] +xref: MEDSCAN:urn:agi-complex:CD8 +xref: RE:R-HSA-198899 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:1706 ! CD8A +relationship: inverse_is_a HGNC:1707 ! CD8B + +[Term] +id: FPLX:000091 +name: CDC25 +synonym: "CDC25 family" EXACT [] +synonym: "Cdc25 phosphatases" EXACT [] +synonym: "CDC25" EXACT [] +synonym: "Cdc25" EXACT [] +xref: BEL:"CDC25 Family" +xref: IP:IPR000751 +xref: MEDSCAN:urn:agi-aopfc:0000551 +xref: RE:R-HSA-170108 +xref: RE:R-HSA-69261 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:1725 ! CDC25A +relationship: inverse_is_a HGNC:1726 ! CDC25B +relationship: inverse_is_a HGNC:1727 ! CDC25C + +[Term] +id: FPLX:000092 +name: CDK +synonym: "CDK" EXACT [] +synonym: "Cdk" EXACT [] +synonym: "CDKs" EXACT [] +xref: ECCODE:2.7.11.22 +xref: MEDSCAN:urn:agi-complex:prophash-4dda466320b1a32b046d823accadbaee +xref: MESH:D018844 +xref: NCIT:C17767 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:1781 ! CDKL1 +relationship: inverse_is_a HGNC:1782 ! CDKL2 +relationship: inverse_is_a HGNC:15483 ! CDKL3 +relationship: inverse_is_a HGNC:19287 ! CDKL4 +relationship: inverse_is_a HGNC:11411 ! CDKL5 +relationship: inverse_is_a FPLX:000093 ! CDK1_2 +relationship: inverse_is_a HGNC:1772 ! CDK3 +relationship: inverse_is_a HGNC:1773 ! CDK4 +relationship: inverse_is_a HGNC:1774 ! CDK5 +relationship: inverse_is_a HGNC:1777 ! CDK6 +relationship: inverse_is_a HGNC:1778 ! CDK7 +relationship: inverse_is_a HGNC:1779 ! CDK8 +relationship: inverse_is_a HGNC:1780 ! CDK9 +relationship: inverse_is_a HGNC:1770 ! CDK10 +relationship: inverse_is_a HGNC:1730 ! CDK11A +relationship: inverse_is_a HGNC:1729 ! CDK11B +relationship: inverse_is_a HGNC:24224 ! CDK12 +relationship: inverse_is_a HGNC:1733 ! CDK13 +relationship: inverse_is_a HGNC:8883 ! CDK14 +relationship: inverse_is_a HGNC:14434 ! CDK15 +relationship: inverse_is_a HGNC:8749 ! CDK16 +relationship: inverse_is_a HGNC:8750 ! CDK17 +relationship: inverse_is_a HGNC:8751 ! CDK18 +relationship: inverse_is_a HGNC:19338 ! CDK19 +relationship: inverse_is_a HGNC:21420 ! CDK20 + +[Term] +id: FPLX:000093 +name: CDK1-2 +synonym: "CDK1/2" EXACT [] +synonym: "cdk1/2" EXACT [] +synonym: "Cdk1/2" EXACT [] +is_a: FPLX:000092 ! CDK +relationship: inverse_is_a HGNC:1722 ! CDK1 +relationship: inverse_is_a HGNC:1771 ! CDK2 + +[Term] +id: FPLX:000094 +name: CDKN +synonym: "CDKN" EXACT [] +synonym: "CKI" EXACT [] +synonym: "cyclin dependent kinase inhibitors" EXACT [] +synonym: "cyclin-dependent kinase inhibitor" EXACT [] +synonym: "cyclin-dependent protein kinase inhibitors" EXACT [] +xref: NCIT:C18492 +xref: XFAM:PF02234 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a FPLX:000095 ! CDKN1 +relationship: inverse_is_a FPLX:000096 ! CDKN2 +relationship: inverse_is_a HGNC:1791 ! CDKN3 + +[Term] +id: FPLX:000095 +name: CDKN1 +synonym: "CDKN1" EXACT [] +xref: IP:IPR003175 +xref: RE:R-HSA-8941923 +xref: RE:R-HSA-8942604 +xref: RE:R-HSA-8948131 +is_a: FPLX:000094 ! CDKN +relationship: inverse_is_a HGNC:1784 ! CDKN1A +relationship: inverse_is_a HGNC:1785 ! CDKN1B +relationship: inverse_is_a HGNC:1786 ! CDKN1C + +[Term] +id: FPLX:000096 +name: CDKN2 +synonym: "CDKN2" EXACT [] +is_a: FPLX:000094 ! CDKN +relationship: inverse_is_a HGNC:1787 ! CDKN2A +relationship: inverse_is_a HGNC:1788 ! CDKN2B +relationship: inverse_is_a HGNC:1789 ! CDKN2C +relationship: inverse_is_a HGNC:1790 ! CDKN2D + +[Term] +id: FPLX:000097 +name: CEBP +synonym: "C/EBP" EXACT [] +synonym: "CCAAT/enhancer binding protein" EXACT [] +xref: BEL:"CEBP Family" +xref: NEXTPROT-FAMILY:00406 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:1833 ! CEBPA +relationship: inverse_is_a HGNC:1834 ! CEBPB +relationship: inverse_is_a HGNC:1835 ! CEBPD +relationship: inverse_is_a HGNC:1837 ! CEBPG +relationship: inverse_is_a HGNC:1836 ! CEBPE + +[Term] +id: FPLX:000098 +name: CHEK +synonym: "checkpoint kinase" EXACT [] +synonym: "Chk1/2" EXACT [] +xref: MEDSCAN:urn:agi-protfc:checkpoint%20kinase +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:1925 ! CHEK1 +relationship: inverse_is_a HGNC:16627 ! CHEK2 + +[Term] +id: FPLX:000099 +name: Chemokine +synonym: "chemokine" EXACT [] +synonym: "chemokines" EXACT [] +xref: MEDSCAN:urn:agi-aopfc:0000391 +xref: NCIT:C20466 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a FPLX:000128 ! CXCL_ELR_negative +relationship: inverse_is_a FPLX:000129 ! CXCL_ELR_positive + +[Term] +id: FPLX:000100 +name: Chemokine-receptor +synonym: "chemoattractant receptor" EXACT [] +xref: BEL:"Chemokine Receptor Family" +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:1565 ! ACKR2 +relationship: inverse_is_a HGNC:1602 ! CCR1 +relationship: inverse_is_a HGNC:4474 ! CCR10 +relationship: inverse_is_a HGNC:1603 ! CCR2 +relationship: inverse_is_a HGNC:1604 ! CCR3 +relationship: inverse_is_a HGNC:1605 ! CCR4 +relationship: inverse_is_a HGNC:1606 ! CCR5 +relationship: inverse_is_a HGNC:1607 ! CCR6 +relationship: inverse_is_a HGNC:1608 ! CCR7 +relationship: inverse_is_a HGNC:1609 ! CCR8 +relationship: inverse_is_a HGNC:1610 ! CCR9 +relationship: inverse_is_a HGNC:1611 ! ACKR4 +relationship: inverse_is_a HGNC:1612 ! CCRL2 +relationship: inverse_is_a HGNC:2558 ! CX3CR1 +relationship: inverse_is_a HGNC:6026 ! CXCR1 +relationship: inverse_is_a HGNC:6027 ! CXCR2 +relationship: inverse_is_a HGNC:4540 ! CXCR3 +relationship: inverse_is_a HGNC:2561 ! CXCR4 +relationship: inverse_is_a HGNC:1060 ! CXCR5 +relationship: inverse_is_a HGNC:16647 ! CXCR6 +relationship: inverse_is_a HGNC:23692 ! ACKR3 +relationship: inverse_is_a HGNC:1625 ! XCR1 + +[Term] +id: FPLX:000101 +name: Cholinesterase +synonym: "choline esterase" EXACT [] +synonym: "cholinesterase" EXACT [] +xref: BEL:"Cholinesterase Family" +xref: IP:IPR000997 +xref: IP:IPR014788 +xref: RE:R-HSA-2990868 +xref: RE:R-HSA-3640837 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:108 ! ACHE +relationship: inverse_is_a HGNC:983 ! BCHE + +[Term] +id: FPLX:000102 +name: CHRM +synonym: "acetylcholine receptor" EXACT [] +xref: BEL:"CHRM Family" +xref: IP:IPR000995 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:1950 ! CHRM1 +relationship: inverse_is_a HGNC:1951 ! CHRM2 +relationship: inverse_is_a HGNC:1952 ! CHRM3 +relationship: inverse_is_a HGNC:1953 ! CHRM4 +relationship: inverse_is_a HGNC:1954 ! CHRM5 + +[Term] +id: FPLX:000103 +name: CHRN +synonym: "nAChR" EXACT [] +synonym: "nicotine class acetylcholine receptors" EXACT [] +synonym: "nicotinic acetylcholine receptor" EXACT [] +xref: BEL:"CHRN Complex" +xref: GO:0016904 +is_a: FPLX:000000 ! famplex +relationship: has_part HGNC:1956 ! CHRNA2 +relationship: has_part HGNC:1957 ! CHRNA3 +relationship: has_part HGNC:1958 ! CHRNA4 +relationship: has_part HGNC:1959 ! CHRNA5 +relationship: has_part HGNC:15963 ! CHRNA6 +relationship: has_part HGNC:1960 ! CHRNA7 +relationship: has_part HGNC:1962 ! CHRNB2 +relationship: has_part HGNC:1963 ! CHRNB3 +relationship: has_part HGNC:1964 ! CHRNB4 + +[Term] +id: FPLX:000104 +name: CK2 +synonym: "casein kinase 2" EXACT [] +synonym: "casein kinase II complex" EXACT [] +synonym: "casein kinase II" EXACT [] +synonym: "CK2" EXACT [] +xref: BEL:"CK II Complex" +xref: GO:0005956 +xref: NCIT:C107559 +xref: NEXTPROT-FAMILY:03101 +xref: RE:R-HSA-201711 +xref: RE:R-HSA-6805066 +is_a: FPLX:000000 ! famplex +relationship: has_part HGNC:2457 ! CSNK2A1 +relationship: has_part HGNC:2459 ! CSNK2A2 +relationship: has_part HGNC:2460 ! CSNK2B + +[Term] +id: FPLX:000105 +name: Clathrin +synonym: "clathrin coat" EXACT [] +synonym: "clathrin" EXACT [] +xref: BEL:"Clathrin Complex" +xref: GO:0016190 +xref: RE:R-HSA-5138439 +xref: RE:R-HSA-5138447 +xref: RE:R-HSA-5333713 +is_a: FPLX:000000 ! famplex +relationship: has_part HGNC:2090 ! CLTA +relationship: has_part HGNC:2091 ! CLTB +relationship: has_part HGNC:2092 ! CLTC + +[Term] +id: FPLX:000106 +name: CNKSR +synonym: "CNKSR" EXACT [] +synonym: "connector enhancer of kinase suppressor of ras" EXACT [] +xref: NEXTPROT-FAMILY:00653 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:19700 ! CNKSR1 +relationship: inverse_is_a HGNC:19701 ! CNKSR2 + +[Term] +id: FPLX:000107 +name: Cofilin +synonym: "cofilin" EXACT [] +xref: IP:IPR017904 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:1874 ! CFL1 +relationship: inverse_is_a HGNC:1875 ! CFL2 +relationship: inverse_is_a HGNC:15750 ! DSTN + +[Term] +id: FPLX:000108 +name: Cohesin +synonym: "cohesin complex" EXACT [] +synonym: "cohesin" EXACT [] +xref: BEL:"Cohesin Complex" +xref: GO:0008278 +xref: GO:0008279 +xref: XFAM:PF00963 +is_a: FPLX:000000 ! famplex +relationship: has_part HGNC:9811 ! RAD21 +relationship: has_part HGNC:2468 ! SMC3 + +[Term] +id: FPLX:000109 +name: COL1 +synonym: "collagen type I" EXACT [] +synonym: "Type I collagen" EXACT [] +synonym: "type I collagen" EXACT [] +xref: BEL:"COL1 Family" +xref: GO:0005584 +xref: NCIT:C124129 +xref: RE:R-HSA-2089970 +xref: RE:R-HSA-2396039 +xref: RE:R-HSA-2396161 +xref: RE:R-HSA-2396179 +xref: RE:R-HSA-2396183 +xref: RE:R-HSA-2396256 +xref: RE:R-HSA-2396260 +xref: RE:R-HSA-2396334 +xref: RE:R-HSA-2396451 +xref: RE:R-HSA-2396456 +xref: RE:R-HSA-2396478 +xref: RE:R-HSA-2399520 +xref: RE:R-HSA-2428941 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:2197 ! COL1A1 +relationship: inverse_is_a HGNC:2198 ! COL1A2 + +[Term] +id: FPLX:000110 +name: COL4 +synonym: "Col4" EXACT [] +synonym: "ColIV" EXACT [] +synonym: "collagen IV" EXACT [] +synonym: "Collagen Type IV" EXACT [] +synonym: "collagen type IV" EXACT [] +xref: BEL:"COL4 Family" +xref: GO:0005587 +xref: IP:IPR001442 +xref: NCIT:C16448 +xref: RE:R-HSA-2127389 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:2202 ! COL4A1 +relationship: inverse_is_a HGNC:2203 ! COL4A2 +relationship: inverse_is_a HGNC:2204 ! COL4A3 +relationship: inverse_is_a HGNC:2206 ! COL4A4 +relationship: inverse_is_a HGNC:2207 ! COL4A5 +relationship: inverse_is_a HGNC:2208 ! COL4A6 + +[Term] +id: FPLX:000111 +name: COL5 +synonym: "collagen type V" EXACT [] +synonym: "type V collagen" EXACT [] +synonym: "type-V collagen" EXACT [] +xref: BEL:"COL5 Family" +xref: GO:0005588 +xref: RE:R-HSA-2127310 +xref: RE:R-HSA-2127422 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:2209 ! COL5A1 +relationship: inverse_is_a HGNC:2210 ! COL5A2 +relationship: inverse_is_a HGNC:14864 ! COL5A3 + +[Term] +id: FPLX:000112 +name: COLGALT +synonym: "COLGALT" EXACT [] +synonym: "Collagen beta(1-O)galactosyltransferase" EXACT [] +synonym: "Collagen beta(1-O)galactosyltransferases" EXACT [] +synonym: "collagen beta(1-O)galactosyltransferase" EXACT [] +synonym: "collagen beta(1-O)galactosyltransferases" EXACT [] +is_a: FPLX:000198 ! Glycosyltransferase +relationship: inverse_is_a HGNC:26182 ! COLGALT1 +relationship: inverse_is_a HGNC:16790 ! COLGALT2 + +[Term] +id: FPLX:000113 +name: COX +synonym: "Complex IV" EXACT [] +synonym: "cytochrome c oxidase" EXACT [] +xref: BEL:"Cytochrome C Oxidase Complex Muscle" +xref: BEL:"Cytochrome C Oxidase Complex Non Muscle" +xref: ECCODE:1.9.3.1 +is_a: FPLX:000000 ! famplex +relationship: has_part HGNC:2267 ! COX5A +relationship: has_part HGNC:2269 ! COX5B +relationship: has_part FPLX:000114 ! COX4 +relationship: has_part FPLX:000115 ! COX6A +relationship: has_part FPLX:000116 ! COX6B +relationship: has_part FPLX:000117 ! COX7A +relationship: has_part FPLX:000118 ! COX7B +relationship: has_part FPLX:000119 ! COX8 +relationship: has_part HGNC:2260 ! COX10 +relationship: has_part HGNC:2261 ! COX11 +relationship: has_part HGNC:2263 ! COX15 +relationship: has_part HGNC:2264 ! COX17 + +[Term] +id: FPLX:000114 +name: COX4 +synonym: "Cox4" EXACT [] +xref: BEL:"COX4 Family" +xref: IP:IPR004203 +xref: IP:IPR013288 +xref: XFAM:PF02936 +relationship: part_of FPLX:000113 ! COX +relationship: inverse_is_a HGNC:2265 ! COX4I1 +relationship: inverse_is_a HGNC:16232 ! COX4I2 + +[Term] +id: FPLX:000115 +name: COX6A +synonym: "COX6A" EXACT [] +synonym: "Cox6a" EXACT [] +synonym: "Cytochrome c oxidase subunit 6a" EXACT [] +xref: BEL:"COX6A Family" +xref: IP:IPR001349 +xref: IP:IPR018507 +xref: XFAM:PF02046 +relationship: part_of FPLX:000113 ! COX +relationship: inverse_is_a HGNC:2277 ! COX6A1 +relationship: inverse_is_a HGNC:2279 ! COX6A2 + +[Term] +id: FPLX:000116 +name: COX6B +synonym: "Cox6b" EXACT [] +xref: BEL:"COX6B Family" +xref: XFAM:PF02297 +relationship: part_of FPLX:000113 ! COX +relationship: inverse_is_a HGNC:2280 ! COX6B1 +relationship: inverse_is_a HGNC:24380 ! COX6B2 + +[Term] +id: FPLX:000117 +name: COX7A +synonym: "COX7A" EXACT [] +synonym: "Cox7a" EXACT [] +xref: BEL:"COX7A Family" +xref: XFAM:PF02238 +relationship: part_of FPLX:000113 ! COX +relationship: inverse_is_a HGNC:2287 ! COX7A1 +relationship: inverse_is_a HGNC:2288 ! COX7A2 + +[Term] +id: FPLX:000118 +name: COX7B +synonym: "Cox7b" EXACT [] +xref: BEL:"COX7B Family" +xref: IP:IPR008433 +xref: IP:IPR023272 +xref: XFAM:PF05392 +relationship: part_of FPLX:000113 ! COX +relationship: inverse_is_a HGNC:2291 ! COX7B +relationship: inverse_is_a HGNC:24381 ! COX7B2 + +[Term] +id: FPLX:000119 +name: COX8 +synonym: "Cox8" EXACT [] +synonym: "cytochrome c oxidase subunit VIII" EXACT [] +xref: BEL:"COX8 Family" +xref: IP:IPR003205 +xref: XFAM:PF02285 +relationship: part_of FPLX:000113 ! COX +relationship: inverse_is_a HGNC:2294 ! COX8A +relationship: inverse_is_a HGNC:24382 ! COX8C + +[Term] +id: FPLX:000120 +name: CREB +synonym: "CREB family" EXACT [] +synonym: "CREB" EXACT [] +xref: BEL:"CREB Family" +xref: MEDSCAN:urn:agi-aopfc:0000094 +xref: NCIT:C17286 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:2345 ! CREB1 +relationship: inverse_is_a HGNC:2347 ! CREB3 +relationship: inverse_is_a HGNC:16844 ! CREB5 +relationship: inverse_is_a HGNC:18856 ! CREB3L1 +relationship: inverse_is_a HGNC:23720 ! CREB3L2 +relationship: inverse_is_a HGNC:18855 ! CREB3L3 +relationship: inverse_is_a HGNC:18854 ! CREB3L4 +relationship: inverse_is_a HGNC:2352 ! CREM +relationship: inverse_is_a HGNC:783 ! ATF1 +relationship: inverse_is_a HGNC:784 ! ATF2 + +[Term] +id: FPLX:000121 +name: CRISP +synonym: "CRISP" EXACT [] +synonym: "CRISPs" EXACT [] +synonym: "cysteine rich secretory proteins" EXACT [] +synonym: "cysteine-rich secretory proteins" EXACT [] +xref: BEL:"CRISP Family" +xref: IP:IPR013871 +xref: IP:IPR034117 +xref: XFAM:PF08562 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:304 ! CRISP1 +relationship: inverse_is_a HGNC:12024 ! CRISP2 +relationship: inverse_is_a HGNC:16904 ! CRISP3 + +[Term] +id: FPLX:000122 +name: CRSP +synonym: "CRSP complex" EXACT [] +synonym: "CRSP" EXACT [] +synonym: "CRSP/Med complex" EXACT [] +synonym: "transcriptional cofactor complex CRSP" EXACT [] +xref: BEL:"CRSP Complex" +xref: NCIT:C28687 +is_a: FPLX:000000 ! famplex +relationship: has_part HGNC:9234 ! MED1 +relationship: has_part HGNC:2370 ! MED14 +relationship: has_part HGNC:2375 ! MED17 +relationship: has_part HGNC:2372 ! MED23 +relationship: has_part HGNC:2376 ! MED26 +relationship: has_part HGNC:2377 ! MED27 +relationship: has_part HGNC:2378 ! MED7 + +[Term] +id: FPLX:000123 +name: CRTC +synonym: "CRTC" EXACT [] +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:16062 ! CRTC1 +relationship: inverse_is_a HGNC:27301 ! CRTC2 +relationship: inverse_is_a HGNC:26148 ! CRTC3 + +[Term] +id: FPLX:000124 +name: CSNK1 +synonym: "Casein kinase 1" EXACT [] +synonym: "casein kinase 1" EXACT [] +synonym: "casein kinase I" EXACT [] +synonym: "CSNK1" EXACT [] +xref: BEL:"CSNK1 Family" +xref: MEDSCAN:urn:agi-protfc:casein%20kinase%20I +xref: NEXTPROT-FAMILY:03083 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:2451 ! CSNK1A1 +relationship: inverse_is_a HGNC:20289 ! CSNK1A1L +relationship: inverse_is_a HGNC:2452 ! CSNK1D +relationship: inverse_is_a HGNC:2453 ! CSNK1E +relationship: inverse_is_a HGNC:2454 ! CSNK1G1 +relationship: inverse_is_a HGNC:2455 ! CSNK1G2 +relationship: inverse_is_a HGNC:2456 ! CSNK1G3 + +[Term] +id: FPLX:000125 +name: CSNK2 +synonym: "CSNK2" EXACT [] +xref: BEL:"CSNK2 Family" +xref: RE:R-HSA-5083623 +xref: RE:R-HSA-5083624 +xref: RE:R-HSA-6805064 +xref: RE:R-HSA-6805073 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:2457 ! CSNK2A1 +relationship: inverse_is_a HGNC:2459 ! CSNK2A2 + +[Term] +id: FPLX:000126 +name: CTNNA +synonym: "a-cathenin" EXACT [] +synonym: "alpha catenin" EXACT [] +synonym: "alpha-catenin" EXACT [] +synonym: "catenin alpha" EXACT [] +synonym: "catenin α" EXACT [] +synonym: "α catenin" EXACT [] +synonym: "α-catenin" EXACT [] +xref: BEL:"CTNNA Family" +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:2509 ! CTNNA1 +relationship: inverse_is_a HGNC:2510 ! CTNNA2 +relationship: inverse_is_a HGNC:2511 ! CTNNA3 + +[Term] +id: FPLX:000127 +name: CUL +synonym: "cullin proteins" EXACT [] +synonym: "cullin" EXACT [] +synonym: "cullins" EXACT [] +xref: BEL:"CUL Family" +xref: MEDSCAN:urn:agi-complex:prophash-c3bac0781a4430da4cf6721b8f7537d9 +xref: MEDSCAN:urn:agi-protfc:cullin +xref: NEXTPROT-FAMILY:00787 +xref: XFAM:PF00888 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:2551 ! CUL1 +relationship: inverse_is_a HGNC:2552 ! CUL2 +relationship: inverse_is_a HGNC:2553 ! CUL3 +relationship: inverse_is_a HGNC:2554 ! CUL4A +relationship: inverse_is_a HGNC:2555 ! CUL4B +relationship: inverse_is_a HGNC:2556 ! CUL5 +relationship: inverse_is_a HGNC:21024 ! CUL7 + +[Term] +id: FPLX:000128 +name: CXCL-ELR-negative +synonym: "ELR (-) CXC chemokines" EXACT [] +synonym: "ELR-negative CXC chemokine" EXACT [] +synonym: "ELR-negative CXC family" EXACT [] +synonym: "non-ELR-CXC chemokines" EXACT [] +xref: BEL:"CXCL ELR-Negative Family" +is_a: FPLX:000099 ! Chemokine +relationship: inverse_is_a HGNC:10637 ! CXCL10 +relationship: inverse_is_a HGNC:10638 ! CXCL11 +relationship: inverse_is_a HGNC:10672 ! CXCL12 +relationship: inverse_is_a HGNC:10639 ! CXCL13 +relationship: inverse_is_a HGNC:10640 ! CXCL14 +relationship: inverse_is_a HGNC:7098 ! CXCL9 +relationship: inverse_is_a HGNC:8861 ! PF4 + +[Term] +id: FPLX:000129 +name: CXCL-ELR-positive +synonym: "ELR (+) CXC chemokines" EXACT [] +synonym: "ELR-positive CXC chemokine" EXACT [] +synonym: "ELR-positive CXC family" EXACT [] +xref: BEL:"CXCL ELR-Positive Family" +is_a: FPLX:000099 ! Chemokine +relationship: inverse_is_a HGNC:4602 ! CXCL1 +relationship: inverse_is_a HGNC:4603 ! CXCL2 +relationship: inverse_is_a HGNC:4604 ! CXCL3 +relationship: inverse_is_a HGNC:10642 ! CXCL5 +relationship: inverse_is_a HGNC:10643 ! CXCL6 +relationship: inverse_is_a HGNC:6025 ! CXCL8 +relationship: inverse_is_a HGNC:9240 ! PPBP + +[Term] +id: FPLX:000130 +name: Cyclin +synonym: "cyclin family" EXACT [] +synonym: "Cyclin" EXACT [] +synonym: "cyclin" EXACT [] +synonym: "cyclins" EXACT [] +xref: MEDSCAN:urn:agi-protfc:cyclin +xref: NCIT:C17349 +xref: NEXTPROT-FAMILY:00815 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:1579 ! CCNB1 +relationship: inverse_is_a HGNC:1580 ! CCNB2 +relationship: inverse_is_a HGNC:18709 ! CCNB3 +relationship: inverse_is_a HGNC:1581 ! CCNC +relationship: inverse_is_a HGNC:1591 ! CCNF +relationship: inverse_is_a HGNC:1592 ! CCNG1 +relationship: inverse_is_a HGNC:1593 ! CCNG2 +relationship: inverse_is_a HGNC:1594 ! CCNH +relationship: inverse_is_a HGNC:1595 ! CCNI +relationship: inverse_is_a HGNC:33869 ! CCNI2 +relationship: inverse_is_a HGNC:23434 ! CCNJ +relationship: inverse_is_a HGNC:25876 ! CCNJL +relationship: inverse_is_a HGNC:1596 ! CCNK +relationship: inverse_is_a HGNC:20569 ! CCNL1 +relationship: inverse_is_a HGNC:20570 ! CCNL2 +relationship: inverse_is_a HGNC:18576 ! CCNO +relationship: inverse_is_a HGNC:1599 ! CCNT1 +relationship: inverse_is_a HGNC:1600 ! CCNT2 +relationship: inverse_is_a HGNC:23354 ! CCNY +relationship: inverse_is_a HGNC:26868 ! CCNYL1 +relationship: inverse_is_a HGNC:33206 ! CCNYL3 +relationship: inverse_is_a FPLX:000131 ! Cyclin_A +relationship: inverse_is_a FPLX:000132 ! Cyclin_D +relationship: inverse_is_a FPLX:000133 ! Cyclin_E + +[Term] +id: FPLX:000131 +name: Cyclin-A +synonym: "Cyclin A" EXACT [] +synonym: "cyclin A" EXACT [] +synonym: "Cyclin-A" EXACT [] +xref: BEL:"CCNA Family" +xref: RE:R-HSA-170089 +xref: RE:R-HSA-174074 +xref: RE:R-HSA-5696998 +xref: RE:R-HSA-6783051 +xref: RE:R-HSA-75202 +is_a: FPLX:000130 ! Cyclin +relationship: inverse_is_a HGNC:1577 ! CCNA1 +relationship: inverse_is_a HGNC:1578 ! CCNA2 + +[Term] +id: FPLX:000132 +name: Cyclin-D +synonym: "Cyclin D" EXACT [] +xref: BEL:"CCND Family" +xref: IP:IPR015451 +xref: NCIT:C104194 +xref: NEXTPROT-FAMILY:00818 +xref: RE:R-HSA-182582 +xref: RE:R-HSA-182700 +xref: RE:R-HSA-8938866 +is_a: FPLX:000130 ! Cyclin +relationship: inverse_is_a HGNC:1582 ! CCND1 +relationship: inverse_is_a HGNC:1583 ! CCND2 +relationship: inverse_is_a HGNC:1585 ! CCND3 + +[Term] +id: FPLX:000133 +name: Cyclin-E +synonym: "cyclin E" EXACT [] +xref: BEL:"CCNE Family" +xref: IP:IPR028858 +xref: NCIT:C104197 +xref: NEXTPROT-FAMILY:00819 +xref: RE:R-HSA-157462 +xref: RE:R-HSA-187493 +xref: RE:R-HSA-6813837 +xref: RE:R-HSA-68373 +is_a: FPLX:000130 ! Cyclin +relationship: inverse_is_a HGNC:1589 ! CCNE1 +relationship: inverse_is_a HGNC:1590 ! CCNE2 + +[Term] +id: FPLX:000134 +name: Cyclophilin +synonym: "cyclophilin" EXACT [] +synonym: "cyclophilins" EXACT [] +xref: BEL:"Cyclophilin Family" +xref: MEDSCAN:urn:agi-protfc:cyclophilins +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:10664 ! CWC27 +relationship: inverse_is_a HGNC:9253 ! PPIA +relationship: inverse_is_a HGNC:9255 ! PPIB +relationship: inverse_is_a HGNC:9256 ! PPIC +relationship: inverse_is_a HGNC:9257 ! PPID +relationship: inverse_is_a HGNC:9258 ! PPIE +relationship: inverse_is_a HGNC:9259 ! PPIF +relationship: inverse_is_a HGNC:14651 ! PPIH +relationship: inverse_is_a HGNC:9260 ! PPIL1 +relationship: inverse_is_a HGNC:9261 ! PPIL2 +relationship: inverse_is_a HGNC:9262 ! PPIL3 +relationship: inverse_is_a HGNC:15702 ! PPIL4 +relationship: inverse_is_a HGNC:21557 ! PPIL6 +relationship: inverse_is_a HGNC:28954 ! PPWD1 +relationship: inverse_is_a HGNC:24369 ! PPIAL4A +relationship: inverse_is_a HGNC:33995 ! PPIAL4C +relationship: inverse_is_a HGNC:33996 ! PPIAL4G + +[Term] +id: FPLX:000135 +name: Cytoplasmic-dynein +synonym: "cytoplasmic dynein" EXACT [] +xref: BEL:"Cytoplasmic Dynein Complex" +xref: GO:0005868 +is_a: FPLX:000000 ! famplex +relationship: has_part HGNC:2961 ! DYNC1H1 +relationship: has_part HGNC:2963 ! DYNC1I1 +relationship: has_part HGNC:2964 ! DYNC1I2 +relationship: has_part HGNC:18745 ! DYNC1LI1 +relationship: has_part HGNC:2966 ! DYNC1LI2 +relationship: has_part HGNC:15476 ! DYNLL1 +relationship: has_part HGNC:15468 ! DYNLRB1 +relationship: has_part HGNC:15467 ! DYNLRB2 + +[Term] +id: FPLX:000136 +name: DDR +synonym: "discoidin domain receptor family" EXACT [] +synonym: "discoidin domain receptors" EXACT [] +synonym: "discoidin domain-containing receptor" EXACT [] +xref: BEL:"DDR Family" +xref: MEDSCAN:urn:agi-aopfc:0000252 +xref: XFAM:PF08841 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:2730 ! DDR1 +relationship: inverse_is_a HGNC:2731 ! DDR2 + +[Term] +id: FPLX:000137 +name: Death-receptor +synonym: "death receptor" EXACT [] +synonym: "death receptors" EXACT [] +xref: GO:0005035 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:11916 ! TNFRSF1A +relationship: inverse_is_a HGNC:11917 ! TNFRSF1B +relationship: inverse_is_a HGNC:11904 ! TNFRSF10A +relationship: inverse_is_a HGNC:11905 ! TNFRSF10B +relationship: inverse_is_a HGNC:11906 ! TNFRSF10C +relationship: inverse_is_a HGNC:11907 ! TNFRSF10D +relationship: inverse_is_a HGNC:11920 ! FAS + +[Term] +id: FPLX:000138 +name: Desmoglein +synonym: "desmoglein" EXACT [] +synonym: "desmogleins" EXACT [] +xref: BEL:"Desmoglein Family" +xref: IP:IPR009123 +xref: MEDSCAN:urn:agi-protfc:desmoglein +xref: RE:R-HSA-6814694 +xref: RE:R-HSA-8847714 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:3048 ! DSG1 +relationship: inverse_is_a HGNC:3049 ! DSG2 +relationship: inverse_is_a HGNC:3050 ! DSG3 +relationship: inverse_is_a HGNC:21307 ! DSG4 + +[Term] +id: FPLX:000139 +name: DGC +synonym: "DGC" EXACT [] +synonym: "dystrophin glycoprotein complex" EXACT [] +synonym: "dystrophin glycoprotein" EXACT [] +synonym: "dystrophin-associated glycoprotein complex" EXACT [] +synonym: "dystrophin-glycoprotein complex" EXACT [] +xref: BEL:"Dystrophin Associated Glycoprotein Complex" +xref: GO:0016010 +is_a: FPLX:000000 ! famplex +relationship: has_part HGNC:2666 ! DAG1 +relationship: has_part HGNC:2928 ! DMD +relationship: has_part HGNC:3057 ! DTNA +relationship: has_part HGNC:3058 ! DTNB +relationship: has_part HGNC:7872 ! NOS1 +relationship: has_part HGNC:10805 ! SGCA +relationship: has_part HGNC:10806 ! SGCB +relationship: has_part HGNC:10807 ! SGCD +relationship: has_part HGNC:10808 ! SGCE +relationship: has_part HGNC:14075 ! SGCZ +relationship: has_part HGNC:11167 ! SNTA1 +relationship: has_part HGNC:11168 ! SNTB1 +relationship: has_part HGNC:13740 ! SNTG1 +relationship: has_part HGNC:13741 ! SNTG2 +relationship: has_part HGNC:11322 ! SSPN +relationship: has_part HGNC:12635 ! UTRN + +[Term] +id: FPLX:000140 +name: DGK +synonym: "DAG kinase" EXACT [] +synonym: "DGK" EXACT [] +synonym: "diacyl glycerol kinase" EXACT [] +synonym: "diacylglycerol kinase" EXACT [] +xref: BEL:"DGK Family" +xref: ECCODE:2.7.1.107 +xref: IP:IPR000756 +xref: RE:R-HSA-426070 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:2849 ! DGKA +relationship: inverse_is_a HGNC:2850 ! DGKB +relationship: inverse_is_a HGNC:2851 ! DGKD +relationship: inverse_is_a HGNC:2853 ! DGKG +relationship: inverse_is_a HGNC:2854 ! DGKH +relationship: inverse_is_a HGNC:2856 ! DGKQ +relationship: inverse_is_a HGNC:2857 ! DGKZ +relationship: inverse_is_a HGNC:2852 ! DGKE +relationship: inverse_is_a HGNC:2855 ! DGKI +relationship: inverse_is_a HGNC:32395 ! DGKK + +[Term] +id: FPLX:000141 +name: DNA-polymerase-delta +synonym: "DNA polymerase delta" EXACT [] +synonym: "DNA polymerase δ" EXACT [] +synonym: "Pol delta" EXACT [] +synonym: "pol delta" EXACT [] +synonym: "Pol δ" EXACT [] +synonym: "pol δ" EXACT [] +xref: BEL:"DNA Polymerase delta Complex" +xref: GO:0043625 +xref: NCIT:C16511 +xref: RE:R-HSA-68450 +is_a: FPLX:000000 ! famplex +relationship: has_part HGNC:9175 ! POLD1 +relationship: has_part HGNC:9176 ! POLD2 +relationship: has_part HGNC:20932 ! POLD3 +relationship: has_part HGNC:14106 ! POLD4 + +[Term] +id: FPLX:000142 +name: DNM +synonym: "dynamin family" EXACT [] +synonym: "dynamin" EXACT [] +xref: BEL:"DNM Family" +xref: RE:R-HSA-2213185 +xref: RE:R-HSA-446847 +xref: RE:R-HSA-8868235 +xref: RE:R-HSA-8868609 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:2972 ! DNM1 +relationship: inverse_is_a HGNC:2974 ! DNM2 +relationship: inverse_is_a HGNC:29125 ! DNM3 + +[Term] +id: FPLX:000143 +name: DRD +synonym: "dopamine receptor" EXACT [] +synonym: "dopamine receptors" EXACT [] +xref: BEL:"DRD Family" +xref: GO:0004952 +xref: IP:IPR000929 +xref: NCIT:C17066 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:3020 ! DRD1 +relationship: inverse_is_a HGNC:3023 ! DRD2 +relationship: inverse_is_a HGNC:3024 ! DRD3 +relationship: inverse_is_a HGNC:3025 ! DRD4 +relationship: inverse_is_a HGNC:3026 ! DRD5 + +[Term] +id: FPLX:000144 +name: DUSP +synonym: "DUSP" EXACT [] +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:3064 ! DUSP1 +relationship: inverse_is_a HGNC:3068 ! DUSP2 +relationship: inverse_is_a HGNC:3069 ! DUSP3 +relationship: inverse_is_a HGNC:3070 ! DUSP4 +relationship: inverse_is_a HGNC:3071 ! DUSP5 +relationship: inverse_is_a HGNC:3072 ! DUSP6 + +[Term] +id: FPLX:000145 +name: DVL +synonym: "dishevelled" EXACT [] +synonym: "Dvl" EXACT [] +xref: BEL:"DVL Family" +xref: XFAM:PF02377 +xref: XFAM:PF08137 +xref: RE:R-HSA-1504201 +xref: RE:R-HSA-201689 +xref: RE:R-HSA-201725 +xref: RE:R-HSA-3772407 +xref: RE:R-HSA-3858467 +xref: RE:R-HSA-3858479 +xref: RE:R-HSA-4652685 +xref: SIGNOR:SIGNOR-PF10 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:3084 ! DVL1 +relationship: inverse_is_a HGNC:3086 ! DVL2 +relationship: inverse_is_a HGNC:3087 ! DVL3 + +[Term] +id: FPLX:000146 +name: DYRK +synonym: "DYRK" EXACT [] +xref: NEXTPROT-FAMILY:03091 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:3091 ! DYRK1A +relationship: inverse_is_a HGNC:3092 ! DYRK1B +relationship: inverse_is_a HGNC:3093 ! DYRK2 +relationship: inverse_is_a HGNC:3094 ! DYRK3 +relationship: inverse_is_a HGNC:3095 ! DYRK4 + +[Term] +id: FPLX:000147 +name: E2F +synonym: "E2F" EXACT [] +xref: BEL:"E2F Family" +xref: IP:IPR015633 +xref: MEDSCAN:urn:agi-aopfc:0000099 +xref: MEDSCAN:urn:agi-complex:prophash-40bc2e4348830d6f7bdacd573fd7c388 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:3113 ! E2F1 +relationship: inverse_is_a HGNC:3114 ! E2F2 +relationship: inverse_is_a HGNC:3115 ! E2F3 +relationship: inverse_is_a HGNC:3118 ! E2F4 +relationship: inverse_is_a HGNC:3119 ! E2F5 +relationship: inverse_is_a HGNC:3120 ! E2F6 +relationship: inverse_is_a HGNC:23820 ! E2F7 +relationship: inverse_is_a HGNC:24727 ! E2F8 + +[Term] +id: FPLX:000148 +name: E3-Ub-ligase +synonym: "E3 ubiquitin ligase" EXACT [] +synonym: "E3" EXACT [] +xref: XFAM:PF12483 +xref: RE:R-HSA-976075 +is_a: FPLX:000000 ! famplex + +[Term] +id: FPLX:000149 +name: EDN +synonym: "endothelin" EXACT [] +synonym: "endothelins" EXACT [] +xref: BEL:"EDN Family" +xref: IP:IPR001928 +xref: IP:IPR019764 +xref: IP:IPR020475 +xref: MEDSCAN:urn:agi-protfc:endothelin +xref: XFAM:PF00322 +xref: RE:R-HSA-388544 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:3176 ! EDN1 +relationship: inverse_is_a HGNC:3177 ! EDN2 +relationship: inverse_is_a HGNC:3178 ! EDN3 + +[Term] +id: FPLX:000150 +name: EGFR-ligand +synonym: "EGFR ligand" EXACT [] +synonym: "EGFR ligands" EXACT [] +xref: BEL:"EGFR Ligand Family" +xref: GO:0005154 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:651 ! AREG +relationship: inverse_is_a HGNC:3229 ! EGF +relationship: inverse_is_a HGNC:11765 ! TGFA +relationship: inverse_is_a HGNC:3059 ! HBEGF +relationship: inverse_is_a HGNC:1121 ! BTC +relationship: inverse_is_a HGNC:3443 ! EREG +relationship: inverse_is_a HGNC:17470 ! EPGN + +[Term] +id: FPLX:000151 +name: EGR +synonym: "early growth response proteins" EXACT [] +synonym: "EGR" EXACT [] +xref: BEL:"EGR Family" +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:3238 ! EGR1 +relationship: inverse_is_a HGNC:3239 ! EGR2 +relationship: inverse_is_a HGNC:3240 ! EGR3 +relationship: inverse_is_a HGNC:3241 ! EGR4 + +[Term] +id: FPLX:000152 +name: EIF2B +synonym: "EIF2B" EXACT [] +synonym: "eIF2B" EXACT [] +xref: BEL:"EIF2B Complex" +xref: NCIT:C18162 +xref: RE:R-HSA-72526 +is_a: FPLX:000000 ! famplex +relationship: has_part HGNC:3257 ! EIF2B1 +relationship: has_part HGNC:3258 ! EIF2B2 +relationship: has_part HGNC:3259 ! EIF2B3 +relationship: has_part HGNC:3260 ! EIF2B4 +relationship: has_part HGNC:3261 ! EIF2B5 + +[Term] +id: FPLX:000153 +name: EIF4A +synonym: "eIF4A" EXACT [] +synonym: "eukaryotic initiation factor-4A" EXACT [] +xref: BEL:"EIF4A Family" +xref: NEXTPROT-FAMILY:00921 +xref: RE:R-HSA-429842 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:3282 ! EIF4A1 +relationship: inverse_is_a HGNC:3284 ! EIF4A2 +relationship: inverse_is_a HGNC:18683 ! EIF4A3 + +[Term] +id: FPLX:000154 +name: EIF4EBP +synonym: "4EBP" EXACT [] +synonym: "initiation factor 4E binding proteins" EXACT [] +xref: BEL:"EIF4EBP Family" +xref: GO:0008190 +xref: IP:IPR008606 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:3288 ! EIF4EBP1 +relationship: inverse_is_a HGNC:3289 ! EIF4EBP2 +relationship: inverse_is_a HGNC:3290 ! EIF4EBP3 + +[Term] +id: FPLX:000155 +name: EIF4G +synonym: "eIF4G" EXACT [] +xref: XFAM:PF02854 +xref: RE:R-HSA-1678828 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:3296 ! EIF4G1 +relationship: inverse_is_a HGNC:3297 ! EIF4G2 +relationship: inverse_is_a HGNC:3298 ! EIF4G3 + +[Term] +id: FPLX:000156 +name: ELA +synonym: "elastase" EXACT [] +xref: BEL:"ELA Family" +xref: NEXTPROT-FAMILY:02762 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:913 ! AZU1 +relationship: inverse_is_a HGNC:3308 ! CELA1 +relationship: inverse_is_a HGNC:24609 ! CELA2A +relationship: inverse_is_a HGNC:29995 ! CELA2B +relationship: inverse_is_a HGNC:15944 ! CELA3A +relationship: inverse_is_a HGNC:15945 ! CELA3B +relationship: inverse_is_a HGNC:2523 ! CTRC +relationship: inverse_is_a HGNC:3309 ! ELANE +relationship: inverse_is_a HGNC:9495 ! PRTN3 + +[Term] +id: FPLX:000157 +name: ENO +synonym: "enolase" EXACT [] +xref: BEL:"ENO Family" +xref: IP:IPR000941 +xref: IP:IPR020810 +xref: IP:IPR020811 +xref: NEXTPROT-FAMILY:01112 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:3350 ! ENO1 +relationship: inverse_is_a HGNC:3353 ! ENO2 +relationship: inverse_is_a HGNC:3354 ! ENO3 +relationship: inverse_is_a HGNC:31670 ! ENO4 + +[Term] +id: FPLX:000158 +name: Ephrin-receptor +synonym: "Eph receptor" EXACT [] +synonym: "Eph receptors" EXACT [] +synonym: "ephrin receptor" EXACT [] +xref: BEL:"Ephrin Receptor Family" +xref: IP:IPR001090 +xref: IP:IPR001426 +xref: IP:IPR016257 +xref: IP:IPR027936 +xref: NCIT:C18606 +xref: NEXTPROT-FAMILY:03124 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:3385 ! EPHA1 +relationship: inverse_is_a HGNC:3386 ! EPHA2 +relationship: inverse_is_a HGNC:3387 ! EPHA3 +relationship: inverse_is_a HGNC:3388 ! EPHA4 +relationship: inverse_is_a HGNC:3389 ! EPHA5 +relationship: inverse_is_a HGNC:19296 ! EPHA6 +relationship: inverse_is_a HGNC:3390 ! EPHA7 +relationship: inverse_is_a HGNC:3391 ! EPHA8 +relationship: inverse_is_a HGNC:3392 ! EPHB1 +relationship: inverse_is_a HGNC:3393 ! EPHB2 +relationship: inverse_is_a HGNC:3394 ! EPHB3 +relationship: inverse_is_a HGNC:3395 ! EPHB4 +relationship: inverse_is_a HGNC:3396 ! EPHB6 +relationship: inverse_is_a HGNC:19987 ! EPHA10 + +[Term] +id: FPLX:000159 +name: EPN +synonym: "epsin" EXACT [] +synonym: "epsins" EXACT [] +xref: BEL:"EPN Family" +xref: NEXTPROT-FAMILY:01121 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:21604 ! EPN1 +relationship: inverse_is_a HGNC:18639 ! EPN2 +relationship: inverse_is_a HGNC:18235 ! EPN3 +relationship: inverse_is_a HGNC:23186 ! CLINT1 + +[Term] +id: FPLX:000160 +name: ERBB +synonym: "ErbB" EXACT [] +synonym: "erbB" EXACT [] +xref: BEL:"EGFR/ERBB Family" +xref: IP:IPR016245 +xref: NCIT:C17763 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:3236 ! EGFR +relationship: inverse_is_a HGNC:3430 ! ERBB2 +relationship: inverse_is_a HGNC:3431 ! ERBB3 +relationship: inverse_is_a HGNC:3432 ! ERBB4 + +[Term] +id: FPLX:000161 +name: ERK +synonym: "ERK 1/2" EXACT [] +synonym: "ERK MAPK" EXACT [] +synonym: "ERK mitogen-activated protein kinase" EXACT [] +synonym: "ERK" EXACT [] +synonym: "Erk" EXACT [] +synonym: "ERK-1/2" EXACT [] +synonym: "ERK1/2 MAPK" EXACT [] +synonym: "ERK1/2" EXACT [] +synonym: "Erk1/2" EXACT [] +synonym: "ERKs" EXACT [] +synonym: "Extracellular Signal Regulated Kinase" EXACT [] +synonym: "extracellular signal-regulated kinase" EXACT [] +synonym: "MAPK" EXACT [] +synonym: "phospho-ERK1/2" EXACT [] +xref: BEL:"MAPK Erk1/2 Family" +xref: BEL:"MAPK Erk1/3 Family" +xref: IP:IPR008349 +xref: MEDSCAN:urn:agi-aopfc:0000458 +xref: NCIT:C16376 +xref: NCIT:C26360 +xref: RE:R-HSA-1268261 +xref: RE:R-HSA-169289 +xref: RE:R-HSA-169291 +xref: RE:R-HSA-198701 +xref: RE:R-HSA-2422450 +xref: RE:R-HSA-3656389 +xref: RE:R-HSA-5674338 +xref: RE:R-HSA-5674340 +xref: RE:R-HSA-5674341 +xref: RE:R-HSA-5675361 +xref: RE:R-HSA-5675363 +xref: SIGNOR:SIGNOR-PF1 +is_a: FPLX:000283 ! MAPK +relationship: inverse_is_a HGNC:6871 ! MAPK1 +relationship: inverse_is_a HGNC:6877 ! MAPK3 + +[Term] +id: FPLX:000162 +name: ESR +synonym: "ER" EXACT [] +synonym: "ESR" EXACT [] +xref: BEL:"ESR Family" +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:3467 ! ESR1 +relationship: inverse_is_a HGNC:3468 ! ESR2 + +[Term] +id: FPLX:000163 +name: ETS +synonym: "ETS" EXACT [] +xref: BEL:"ETS Family" +xref: IP:IPR016311 +xref: XFAM:PF00178 +xref: RE:R-HSA-3132719 +xref: RE:R-HSA-3132724 +xref: RE:R-HSA-3200029 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:3488 ! ETS1 +relationship: inverse_is_a HGNC:3489 ! ETS2 + +[Term] +id: FPLX:000164 +name: EXOC +synonym: "EXOC" EXACT [] +synonym: "exocyst complex" EXACT [] +synonym: "exocyst" EXACT [] +xref: GO:0000145 +xref: RE:R-HSA-264974 +xref: RE:R-HSA-5623453 +is_a: FPLX:000000 ! famplex +relationship: has_part HGNC:30380 ! EXOC1 +relationship: has_part HGNC:24968 ! EXOC2 +relationship: has_part HGNC:30378 ! EXOC3 +relationship: has_part HGNC:30389 ! EXOC4 +relationship: has_part HGNC:10696 ! EXOC5 +relationship: has_part HGNC:23196 ! EXOC6 +relationship: has_part HGNC:23214 ! EXOC7 +relationship: has_part HGNC:24659 ! EXOC8 + +[Term] +id: FPLX:000165 +name: EXT +synonym: "Exostosin glycosyltransferase family" EXACT [] +synonym: "exostosin glycosyltransferase family" EXACT [] +synonym: "EXT" EXACT [] +is_a: FPLX:000198 ! Glycosyltransferase +relationship: inverse_is_a HGNC:3515 ! EXTL1 +relationship: inverse_is_a HGNC:3516 ! EXTL2 +relationship: inverse_is_a HGNC:3518 ! EXTL3 +relationship: inverse_is_a HGNC:3512 ! EXT1 +relationship: inverse_is_a HGNC:3513 ! EXT2 + +[Term] +id: FPLX:000166 +name: FANC +synonym: "FANC proteins" EXACT [] +synonym: "FANC" EXACT [] +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:3582 ! FANCA +relationship: inverse_is_a HGNC:3583 ! FANCB +relationship: inverse_is_a HGNC:3584 ! FANCC +relationship: inverse_is_a HGNC:1101 ! BRCA2 +relationship: inverse_is_a HGNC:3585 ! FANCD2 +relationship: inverse_is_a HGNC:3586 ! FANCE +relationship: inverse_is_a HGNC:3587 ! FANCF +relationship: inverse_is_a HGNC:3588 ! FANCG +relationship: inverse_is_a HGNC:25568 ! FANCI +relationship: inverse_is_a HGNC:20473 ! BRIP1 +relationship: inverse_is_a HGNC:20748 ! FANCL +relationship: inverse_is_a HGNC:23168 ! FANCM +relationship: inverse_is_a HGNC:26144 ! PALB2 +relationship: inverse_is_a HGNC:9820 ! RAD51C +relationship: inverse_is_a HGNC:23845 ! SLX4 +relationship: inverse_is_a HGNC:3436 ! ERCC4 +relationship: inverse_is_a HGNC:9817 ! RAD51 +relationship: inverse_is_a HGNC:1100 ! BRCA1 +relationship: inverse_is_a HGNC:25009 ! UBE2T +relationship: inverse_is_a HGNC:12829 ! XRCC2 + +[Term] +id: FPLX:000167 +name: FGF +synonym: "FGF" EXACT [] +xref: BEL:"FGF Family" +xref: GO:0005162 +xref: IP:IPR002209 +xref: XFAM:PF00167 +xref: SIGNOR:SIGNOR-PF8 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:3665 ! FGF1 +relationship: inverse_is_a HGNC:3676 ! FGF2 +relationship: inverse_is_a HGNC:3681 ! FGF3 +relationship: inverse_is_a HGNC:3682 ! FGF4 +relationship: inverse_is_a HGNC:3683 ! FGF5 +relationship: inverse_is_a HGNC:3684 ! FGF6 +relationship: inverse_is_a HGNC:3685 ! FGF7 +relationship: inverse_is_a HGNC:3686 ! FGF8 +relationship: inverse_is_a HGNC:3687 ! FGF9 +relationship: inverse_is_a HGNC:3666 ! FGF10 +relationship: inverse_is_a HGNC:3667 ! FGF11 +relationship: inverse_is_a HGNC:3668 ! FGF12 +relationship: inverse_is_a HGNC:3670 ! FGF13 +relationship: inverse_is_a HGNC:3671 ! FGF14 +relationship: inverse_is_a HGNC:3672 ! FGF16 +relationship: inverse_is_a HGNC:3673 ! FGF17 +relationship: inverse_is_a HGNC:3674 ! FGF18 +relationship: inverse_is_a HGNC:3675 ! FGF19 +relationship: inverse_is_a HGNC:3677 ! FGF20 +relationship: inverse_is_a HGNC:3678 ! FGF21 +relationship: inverse_is_a HGNC:3679 ! FGF22 +relationship: inverse_is_a HGNC:3680 ! FGF23 + +[Term] +id: FPLX:000168 +name: FGFR +synonym: "FGFR" EXACT [] +xref: BEL:"FGFR Family" +xref: GO:0005007 +xref: IP:IPR016248 +xref: NCIT:C17297 +xref: SIGNOR:SIGNOR-PF23 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:3688 ! FGFR1 +relationship: inverse_is_a HGNC:3689 ! FGFR2 +relationship: inverse_is_a HGNC:3690 ! FGFR3 +relationship: inverse_is_a HGNC:3691 ! FGFR4 +relationship: inverse_is_a HGNC:3693 ! FGFRL1 + +[Term] +id: FPLX:000169 +name: Fibrinogen +synonym: "fibrinogen" EXACT [] +xref: BEL:"Fibrinogen Complex" +xref: GO:0005577 +xref: IP:IPR012290 +xref: RE:R-HSA-114617 +xref: RE:R-HSA-114618 +xref: RE:R-HSA-139933 +xref: RE:R-HSA-139934 +xref: RE:R-HSA-140586 +xref: RE:R-HSA-140919 +xref: RE:R-HSA-8870680 +is_a: FPLX:000000 ! famplex +relationship: has_part HGNC:3661 ! FGA +relationship: has_part HGNC:3662 ! FGB +relationship: has_part HGNC:3694 ! FGG + +[Term] +id: FPLX:000170 +name: FLOT +synonym: "flotillin" EXACT [] +xref: BEL:"FLOT Family" +xref: IP:IPR027705 +xref: IP:IPR031905 +xref: MEDSCAN:urn:agi-protfc:flotillin +xref: XFAM:PF15975 +xref: RE:R-HSA-8849894 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:3757 ! FLOT1 +relationship: inverse_is_a HGNC:3758 ! FLOT2 + +[Term] +id: FPLX:000171 +name: FLRT +synonym: "FLRT family" EXACT [] +synonym: "Flrt family" EXACT [] +synonym: "FLRT proteins" EXACT [] +xref: BEL:"FLRT Family" +xref: RE:R-HSA-5656056 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:3760 ! FLRT1 +relationship: inverse_is_a HGNC:3761 ! FLRT2 +relationship: inverse_is_a HGNC:3762 ! FLRT3 + +[Term] +id: FPLX:000172 +name: FNT +synonym: "farnesyltransferase" EXACT [] +synonym: "FTase" EXACT [] +synonym: "protein farnesyltransferase" EXACT [] +xref: ECCODE:2.5.1.58 +xref: RE:R-HSA-2530496 +is_a: FPLX:000000 ! famplex +relationship: has_part HGNC:3782 ! FNTA +relationship: has_part HGNC:3785 ! FNTB + +[Term] +id: FPLX:000173 +name: FOS-family +synonym: "FOS" EXACT [] +synonym: "Fos" EXACT [] +xref: NEXTPROT-FAMILY:00408 +relationship: part_of FPLX:000048 ! AP1 +relationship: inverse_is_a HGNC:3796 ! FOS +relationship: inverse_is_a HGNC:3797 ! FOSB +relationship: inverse_is_a HGNC:13718 ! FOSL1 +relationship: inverse_is_a HGNC:3798 ! FOSL2 + +[Term] +id: FPLX:000174 +name: FOXO +synonym: "FOXO" EXACT [] +synonym: "FoxO" EXACT [] +xref: BEL:"FOXO Family" +xref: IP:IPR032067 +xref: NCIT:C118892 +xref: SIGNOR:SIGNOR-PF27 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:3819 ! FOXO1 +relationship: inverse_is_a HGNC:3821 ! FOXO3 +relationship: inverse_is_a HGNC:7139 ! FOXO4 +relationship: inverse_is_a HGNC:24814 ! FOXO6 + +[Term] +id: FPLX:000175 +name: FSH +synonym: "follicle-stimulating hormone" EXACT [] +synonym: "FSH" EXACT [] +xref: BEL:"Follicle Stimulating Hormone Complex" +xref: GO:0016914 +xref: RE:R-HSA-378947 +is_a: FPLX:000000 ! famplex +relationship: has_part HGNC:1885 ! CGA +relationship: has_part HGNC:3964 ! FSHB + +[Term] +id: FPLX:000176 +name: FUT +synonym: "Fucosyltransferase" EXACT [] +synonym: "Fucosyltransferases" EXACT [] +synonym: "fucosyltransferase" EXACT [] +synonym: "fucosyltransferases" EXACT [] +synonym: "FUT" EXACT [] +is_a: FPLX:000198 ! Glycosyltransferase +relationship: inverse_is_a HGNC:4012 ! FUT1 +relationship: inverse_is_a HGNC:4013 ! FUT2 +relationship: inverse_is_a HGNC:4014 ! FUT3 +relationship: inverse_is_a HGNC:4015 ! FUT4 +relationship: inverse_is_a HGNC:4016 ! FUT5 +relationship: inverse_is_a HGNC:4017 ! FUT6 +relationship: inverse_is_a HGNC:4018 ! FUT7 +relationship: inverse_is_a HGNC:4019 ! FUT8 +relationship: inverse_is_a HGNC:4020 ! FUT9 +relationship: inverse_is_a HGNC:19234 ! FUT10 +relationship: inverse_is_a HGNC:19233 ! FUT11 +relationship: inverse_is_a HGNC:14988 ! POFUT1 +relationship: inverse_is_a HGNC:14683 ! POFUT2 + +[Term] +id: FPLX:000177 +name: FZD +synonym: "Fz" EXACT [] +synonym: "FZD" EXACT [] +xref: BEL:"FZD Family" +xref: MEDSCAN:urn:agi-aopfc:0000197 +xref: MEDSCAN:urn:agi-complex:prophash-047b61fab6d7e7445346cc84dafcb267 +xref: XFAM:PF01534 +xref: RE:R-HSA-517388 +xref: SIGNOR:SIGNOR-PF11 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:4038 ! FZD1 +relationship: inverse_is_a HGNC:4039 ! FZD10 +relationship: inverse_is_a HGNC:4040 ! FZD2 +relationship: inverse_is_a HGNC:4041 ! FZD3 +relationship: inverse_is_a HGNC:4042 ! FZD4 +relationship: inverse_is_a HGNC:4043 ! FZD5 +relationship: inverse_is_a HGNC:4044 ! FZD6 +relationship: inverse_is_a HGNC:4045 ! FZD7 +relationship: inverse_is_a HGNC:4046 ! FZD8 +relationship: inverse_is_a HGNC:4047 ! FZD9 + +[Term] +id: FPLX:000178 +name: F-actin +synonym: "F-actin" EXACT [] +xref: GO:0031941 +xref: MEDSCAN:urn:agi-protfc:F-actin-binding%20protein +is_a: FPLX:000009 ! Actin + +[Term] +id: FPLX:000179 +name: GABR +synonym: "GABA receptor" EXACT [] +synonym: "GABA receptors" EXACT [] +synonym: "GABA-A receptor" EXACT [] +synonym: "gamma-aminobutyric-acid A receptor" EXACT [] +synonym: "γ-aminobutyric-acid A receptor" EXACT [] +xref: BEL:"GABR Family" +xref: GO:0004890 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:4075 ! GABRA1 +relationship: inverse_is_a HGNC:4076 ! GABRA2 +relationship: inverse_is_a HGNC:4077 ! GABRA3 +relationship: inverse_is_a HGNC:4078 ! GABRA4 +relationship: inverse_is_a HGNC:4079 ! GABRA5 +relationship: inverse_is_a HGNC:4080 ! GABRA6 +relationship: inverse_is_a HGNC:4081 ! GABRB1 +relationship: inverse_is_a HGNC:4082 ! GABRB2 +relationship: inverse_is_a HGNC:4083 ! GABRB3 +relationship: inverse_is_a HGNC:4084 ! GABRD +relationship: inverse_is_a HGNC:4085 ! GABRE +relationship: inverse_is_a HGNC:4086 ! GABRG1 +relationship: inverse_is_a HGNC:4087 ! GABRG2 +relationship: inverse_is_a HGNC:4088 ! GABRG3 +relationship: inverse_is_a HGNC:4089 ! GABRP +relationship: inverse_is_a HGNC:14454 ! GABRQ +relationship: inverse_is_a HGNC:4090 ! GABRR1 +relationship: inverse_is_a HGNC:4091 ! GABRR2 +relationship: inverse_is_a HGNC:17969 ! GABRR3 + +[Term] +id: FPLX:000180 +name: GALNT +synonym: "GALNT" EXACT [] +is_a: FPLX:000198 ! Glycosyltransferase +relationship: inverse_is_a HGNC:21725 ! GALNTL5 +relationship: inverse_is_a HGNC:33844 ! GALNTL6 +relationship: inverse_is_a HGNC:4123 ! GALNT1 +relationship: inverse_is_a HGNC:4124 ! GALNT2 +relationship: inverse_is_a HGNC:4125 ! GALNT3 +relationship: inverse_is_a HGNC:4126 ! GALNT4 +relationship: inverse_is_a HGNC:4127 ! GALNT5 +relationship: inverse_is_a HGNC:4128 ! GALNT6 +relationship: inverse_is_a HGNC:4129 ! GALNT7 +relationship: inverse_is_a HGNC:4130 ! GALNT8 +relationship: inverse_is_a HGNC:4131 ! GALNT9 +relationship: inverse_is_a HGNC:19873 ! GALNT10 +relationship: inverse_is_a HGNC:19875 ! GALNT11 +relationship: inverse_is_a HGNC:19877 ! GALNT12 +relationship: inverse_is_a HGNC:23242 ! GALNT13 +relationship: inverse_is_a HGNC:22946 ! GALNT14 +relationship: inverse_is_a HGNC:21531 ! GALNT15 +relationship: inverse_is_a HGNC:23233 ! GALNT16 +relationship: inverse_is_a HGNC:30488 ! GALNT18 +relationship: inverse_is_a HGNC:16347 ! GALNT17 + +[Term] +id: FPLX:000181 +name: Gamma-secretase +synonym: "gamma secretase" EXACT [] +synonym: "gamma-secretase" EXACT [] +synonym: "γ secretase" EXACT [] +xref: BEL:"gamma Secretase Complex" +xref: GO:0070765 +xref: NCIT:C95114 +is_a: FPLX:000000 ! famplex +relationship: has_part HGNC:29509 ! APH1A +relationship: has_part HGNC:9508 ! PSEN1 +relationship: has_part HGNC:30100 ! PSENEN + +[Term] +id: FPLX:000182 +name: GAP +synonym: "GAP" EXACT [] +synonym: "GTPase-activating proteins" EXACT [] +xref: GO:0005096 +xref: NCIT:C17298 +is_a: FPLX:000000 ! famplex + +[Term] +id: FPLX:000183 +name: GAS6-receptor +synonym: "Gas6 receptors" EXACT [] +xref: BEL:"GAS6 Receptor Family" +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:905 ! AXL +relationship: inverse_is_a HGNC:7027 ! MERTK +relationship: inverse_is_a HGNC:12446 ! TYRO3 + +[Term] +id: FPLX:000184 +name: GATA +synonym: "GATA family" EXACT [] +synonym: "GATA" EXACT [] +xref: BEL:"GATA Family" +xref: MEDSCAN:urn:agi-aopfc:0000105 +xref: XFAM:PF00320 +xref: RE:R-HSA-996770 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:4170 ! GATA1 +relationship: inverse_is_a HGNC:4171 ! GATA2 +relationship: inverse_is_a HGNC:4172 ! GATA3 +relationship: inverse_is_a HGNC:4173 ! GATA4 +relationship: inverse_is_a HGNC:15802 ! GATA5 +relationship: inverse_is_a HGNC:4174 ! GATA6 + +[Term] +id: FPLX:000185 +name: GCNT +synonym: "GCNT" EXACT [] +synonym: "XYLT" EXACT [] +synonym: "Xylosyltransferase" EXACT [] +synonym: "Xylosyltransferases" EXACT [] +synonym: "xylosyltransferase" EXACT [] +synonym: "xylosyltransferases" EXACT [] +is_a: FPLX:000198 ! Glycosyltransferase +relationship: inverse_is_a HGNC:4203 ! GCNT1 +relationship: inverse_is_a HGNC:4204 ! GCNT2 +relationship: inverse_is_a HGNC:4205 ! GCNT3 +relationship: inverse_is_a HGNC:17973 ! GCNT4 +relationship: inverse_is_a HGNC:16099 ! GCNT7 +relationship: inverse_is_a HGNC:15516 ! XYLT1 +relationship: inverse_is_a HGNC:15517 ! XYLT2 + +[Term] +id: FPLX:000186 +name: GEF +synonym: "GEF" EXACT [] +synonym: "GEFs" EXACT [] +xref: GO:0008433 +xref: NCIT:C17494 +is_a: FPLX:000000 ! famplex + +[Term] +id: FPLX:000187 +name: GPCR +synonym: "Class C GPCR" EXACT [] +synonym: "GPCR" EXACT [] +synonym: "GPCRs" EXACT [] +xref: MEDSCAN:urn:agi-aopfc:0000311 +xref: MEDSCAN:urn:agi-complex:prophash-763d31b31e177311583df0ac1ea015da +xref: MEDSCAN:urn:agi-protfc:class%20c%20orphan%20receptor +xref: NCIT:C18239 +xref: SIGNOR:SIGNOR-PF33 +is_a: FPLX:000000 ! famplex + +[Term] +id: FPLX:000188 +name: GPIb-IX-V +synonym: "glycoprotein Ib-V-IX complex" EXACT [] +synonym: "Glycoprotein Ib-V-IX" EXACT [] +synonym: "Glycoprotein Ib/V/IX" EXACT [] +synonym: "GPIb-IX-V complex" EXACT [] +synonym: "GPIb-IX-V" EXACT [] +synonym: "GpIb-V-IX" EXACT [] +xref: BEL:"Ib-V-IX Complex" +xref: GO:1990779 +xref: NCIT:C126122 +xref: RE:R-HSA-114668 +is_a: FPLX:000000 ! famplex +relationship: has_part HGNC:4439 ! GP1BA +relationship: has_part HGNC:4440 ! GP1BB +relationship: has_part HGNC:4443 ! GP5 +relationship: has_part HGNC:4444 ! GP9 + +[Term] +id: FPLX:000189 +name: GPIT +synonym: "glycosylphosphatidylinositol transamidase complex" EXACT [] +synonym: "GPI transamidase complex" EXACT [] +synonym: "GPIT complex" EXACT [] +synonym: "GPIT" EXACT [] +xref: BEL:"GPIT Complex" +xref: RE:R-HSA-162690 +is_a: FPLX:000000 ! famplex +relationship: has_part HGNC:4446 ! GPAA1 +relationship: has_part HGNC:8965 ! PIGK +relationship: has_part HGNC:14937 ! PIGS +relationship: has_part HGNC:14938 ! PIGT +relationship: has_part HGNC:15791 ! PIGU + +[Term] +id: FPLX:000190 +name: GPX +synonym: "glutathione peroxidase" EXACT [] +xref: BEL:"GPX Family" +xref: ECCODE:1.11.1.9 +xref: IP:IPR000889 +xref: IP:IPR029760 +xref: NEXTPROT-FAMILY:01553 +xref: XFAM:PF00255 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:4553 ! GPX1 +relationship: inverse_is_a HGNC:4554 ! GPX2 +relationship: inverse_is_a HGNC:4555 ! GPX3 +relationship: inverse_is_a HGNC:4556 ! GPX4 +relationship: inverse_is_a HGNC:4557 ! GPX5 +relationship: inverse_is_a HGNC:4558 ! GPX6 +relationship: inverse_is_a HGNC:4559 ! GPX7 +relationship: inverse_is_a HGNC:33100 ! GPX8 + +[Term] +id: FPLX:000191 +name: GRIA +synonym: "AMPA glutamate receptor" EXACT [] +synonym: "AMPA receptor" EXACT [] +synonym: "AMPA-R" EXACT [] +synonym: "AMPA-subtype ionotropic glutamate receptors" EXACT [] +synonym: "AMPAR" EXACT [] +synonym: "AMPARs" EXACT [] +xref: BEL:"GRIA Family" +xref: GO:0032281 +xref: RE:R-HSA-399713 +xref: RE:R-HSA-416323 +xref: RE:R-HSA-420974 +xref: RE:R-HSA-421001 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:4571 ! GRIA1 +relationship: inverse_is_a HGNC:4572 ! GRIA2 +relationship: inverse_is_a HGNC:4573 ! GRIA3 +relationship: inverse_is_a HGNC:4574 ! GRIA4 + +[Term] +id: FPLX:000192 +name: GRK +synonym: "G protein-coupled receptor kinases" EXACT [] +synonym: "GPCR kinases" EXACT [] +synonym: "GRK" EXACT [] +synonym: "GRKs" EXACT [] +xref: BEL:"GRK Family" +xref: ECCODE:2.7.11.16 +xref: IP:IPR000239 +xref: NCIT:C26233 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a FPLX:000022 ! ADRBK +relationship: inverse_is_a HGNC:10013 ! GRK1 +relationship: inverse_is_a HGNC:4543 ! GRK4 +relationship: inverse_is_a HGNC:4544 ! GRK5 +relationship: inverse_is_a HGNC:4545 ! GRK6 +relationship: inverse_is_a HGNC:17031 ! GRK7 + +[Term] +id: FPLX:000193 +name: GRM +synonym: "glutamate metabotropic receptors" EXACT [] +synonym: "metabotrophic glutamate receptor" EXACT [] +synonym: "metabotropic glutamate receptor" EXACT [] +synonym: "mGluRs" EXACT [] +xref: BEL:"GRM Family" +xref: IP:IPR000162 +xref: MEDSCAN:urn:agi-protfc:mglur +xref: RE:R-HSA-420516 +xref: RE:R-HSA-420519 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:4593 ! GRM1 +relationship: inverse_is_a HGNC:4594 ! GRM2 +relationship: inverse_is_a HGNC:4595 ! GRM3 +relationship: inverse_is_a HGNC:4596 ! GRM4 +relationship: inverse_is_a HGNC:4597 ! GRM5 +relationship: inverse_is_a HGNC:4598 ! GRM6 +relationship: inverse_is_a HGNC:4599 ! GRM7 +relationship: inverse_is_a HGNC:4600 ! GRM8 + +[Term] +id: FPLX:000194 +name: GSK3 +synonym: "GSK-3" EXACT [] +synonym: "GSK3" EXACT [] +xref: BEL:"GSK3 Family" +xref: MEDSCAN:urn:agi-aopfc:0000434 +xref: NEXTPROT-FAMILY:03087 +xref: RE:R-HSA-198358 +xref: RE:R-HSA-198373 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:4616 ! GSK3A +relationship: inverse_is_a HGNC:4617 ! GSK3B + +[Term] +id: FPLX:000195 +name: GST +synonym: "glutathione S-transferase" EXACT [] +synonym: "GST" EXACT [] +synonym: "GSTs" EXACT [] +xref: BEL:"GST Family" +xref: NCIT:C16641 +xref: NEXTPROT-FAMILY:01669 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:4626 ! GSTA1 +relationship: inverse_is_a HGNC:4627 ! GSTA2 +relationship: inverse_is_a HGNC:4628 ! GSTA3 +relationship: inverse_is_a HGNC:4629 ! GSTA4 +relationship: inverse_is_a HGNC:19662 ! GSTA5 +relationship: inverse_is_a HGNC:16906 ! GSTK1 +relationship: inverse_is_a HGNC:4632 ! GSTM1 +relationship: inverse_is_a HGNC:4634 ! GSTM2 +relationship: inverse_is_a HGNC:4635 ! GSTM3 +relationship: inverse_is_a HGNC:4636 ! GSTM4 +relationship: inverse_is_a HGNC:4637 ! GSTM5 +relationship: inverse_is_a HGNC:13312 ! GSTO1 +relationship: inverse_is_a HGNC:23064 ! GSTO2 +relationship: inverse_is_a HGNC:4638 ! GSTP1 +relationship: inverse_is_a HGNC:4641 ! GSTT1 +relationship: inverse_is_a HGNC:4642 ! GSTT2 +relationship: inverse_is_a HGNC:4643 ! GSTZ1 +relationship: inverse_is_a HGNC:33437 ! GSTT2B + +[Term] +id: FPLX:000196 +name: GTF2E +synonym: "general transcription factor II E" EXACT [] +synonym: "TFIIE" EXACT [] +synonym: "transcription factor II E" EXACT [] +synonym: "transcription factor IIE" EXACT [] +xref: BEL:"GTF2E Complex" +xref: GO:0005673 +xref: RE:R-HSA-109633 +is_a: FPLX:000000 ! famplex +relationship: has_part HGNC:4650 ! GTF2E1 +relationship: has_part HGNC:4651 ! GTF2E2 + +[Term] +id: FPLX:000197 +name: GTF2F +synonym: "general transcription factor II F" EXACT [] +synonym: "TFIIF" EXACT [] +synonym: "transcription factor II F" EXACT [] +synonym: "transcription factor IIF" EXACT [] +xref: BEL:"GTF2F Complex" +xref: GO:0005674 +xref: IP:IPR011039 +xref: RE:R-HSA-109631 +is_a: FPLX:000000 ! famplex +relationship: has_part HGNC:4652 ! GTF2F1 +relationship: has_part HGNC:4653 ! GTF2F2 + +[Term] +id: FPLX:000198 +name: Glycosyltransferase +xref: MESH:D016695 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a FPLX:000002 ! A4GALT_family +relationship: inverse_is_a FPLX:000026 ! ALG10 +relationship: inverse_is_a FPLX:000027 ! ALG1_family +relationship: inverse_is_a FPLX:000028 ! ALG3_family +relationship: inverse_is_a FPLX:000029 ! ALG6_family +relationship: inverse_is_a FPLX:000030 ! ALG13_family +relationship: inverse_is_a FPLX:000063 ! B3GAT +relationship: inverse_is_a FPLX:000065 ! Beta_3_4_GTF +relationship: inverse_is_a FPLX:000112 ! COLGALT +relationship: inverse_is_a FPLX:000165 ! EXT +relationship: inverse_is_a FPLX:000176 ! FUT +relationship: inverse_is_a FPLX:000180 ! GALNT +relationship: inverse_is_a FPLX:000185 ! GCNT +relationship: inverse_is_a FPLX:000199 ! GTF_family_2 +relationship: inverse_is_a FPLX:000200 ! GTF_family_6 +relationship: inverse_is_a FPLX:000201 ! GTF_family_8 +relationship: inverse_is_a FPLX:000202 ! GTF_family_29 +relationship: inverse_is_a FPLX:000203 ! GTF_family_90 +relationship: inverse_is_a FPLX:000287 ! MGAT +relationship: inverse_is_a FPLX:000322 ! OGT_family +relationship: inverse_is_a FPLX:000396 ! PYG +relationship: inverse_is_a FPLX:000455 ! STT3 +relationship: inverse_is_a FPLX:000491 ! UGCG +relationship: inverse_is_a FPLX:000492 ! UGT +relationship: inverse_is_a FPLX:000493 ! UGGT + +[Term] +id: FPLX:000199 +name: GTF-family-2 +synonym: "Glycosyltransferase family 2" EXACT [] +synonym: "glycosyltransferase family 2" EXACT [] +is_a: FPLX:000198 ! Glycosyltransferase +relationship: inverse_is_a HGNC:20266 ! ALG5 +relationship: inverse_is_a HGNC:21727 ! B3GNTL1 +relationship: inverse_is_a HGNC:3005 ! DPM1 +relationship: inverse_is_a HGNC:4818 ! HAS1 +relationship: inverse_is_a HGNC:4819 ! HAS2 +relationship: inverse_is_a HGNC:4820 ! HAS3 + +[Term] +id: FPLX:000200 +name: GTF-family-6 +synonym: "Glycosyltransferase family 6" EXACT [] +synonym: "glycosyltransferase family 6" EXACT [] +is_a: FPLX:000198 ! Glycosyltransferase +relationship: inverse_is_a HGNC:79 ! ABO +relationship: inverse_is_a HGNC:30005 ! A3GALT2 +relationship: inverse_is_a HGNC:20460 ! GBGT1 +relationship: inverse_is_a HGNC:23671 ! GLT6D1 + +[Term] +id: FPLX:000201 +name: GTF-family-8 +synonym: "Glycosyltransferase family 8" EXACT [] +synonym: "glycosyltransferase family 8" EXACT [] +is_a: FPLX:000198 ! Glycosyltransferase +relationship: inverse_is_a HGNC:24870 ! GLT8D1 +relationship: inverse_is_a HGNC:24890 ! GLT8D2 +relationship: inverse_is_a HGNC:27482 ! GXYLT1 +relationship: inverse_is_a HGNC:33383 ! GXYLT2 +relationship: inverse_is_a HGNC:4699 ! GYG1 +relationship: inverse_is_a HGNC:4700 ! GYG2 +relationship: inverse_is_a HGNC:6511 ! LARGE1 +relationship: inverse_is_a HGNC:16522 ! LARGE2 +relationship: inverse_is_a HGNC:13530 ! RXYLT1 +relationship: inverse_is_a HGNC:26639 ! XXYLT1 + +[Term] +id: FPLX:000202 +name: GTF-family-29 +synonym: "Glycosyltransferase family 29" EXACT [] +synonym: "glycosyltransferase family 29" EXACT [] +synonym: "Sialytransferase" EXACT [] +synonym: "Sialytransferases" EXACT [] +synonym: "sialytransferase" EXACT [] +synonym: "sialytransferases" EXACT [] +is_a: FPLX:000198 ! Glycosyltransferase +relationship: inverse_is_a HGNC:10862 ! ST3GAL1 +relationship: inverse_is_a HGNC:10863 ! ST3GAL2 +relationship: inverse_is_a HGNC:10866 ! ST3GAL3 +relationship: inverse_is_a HGNC:10864 ! ST3GAL4 +relationship: inverse_is_a HGNC:10872 ! ST3GAL5 +relationship: inverse_is_a HGNC:18080 ! ST3GAL6 +relationship: inverse_is_a HGNC:23614 ! ST6GALNAC1 +relationship: inverse_is_a HGNC:10867 ! ST6GALNAC2 +relationship: inverse_is_a HGNC:19343 ! ST6GALNAC3 +relationship: inverse_is_a HGNC:17846 ! ST6GALNAC4 +relationship: inverse_is_a HGNC:19342 ! ST6GALNAC5 +relationship: inverse_is_a HGNC:23364 ! ST6GALNAC6 +relationship: inverse_is_a HGNC:10860 ! ST6GAL1 +relationship: inverse_is_a HGNC:10861 ! ST6GAL2 +relationship: inverse_is_a HGNC:10869 ! ST8SIA1 +relationship: inverse_is_a HGNC:10870 ! ST8SIA2 +relationship: inverse_is_a HGNC:14269 ! ST8SIA3 +relationship: inverse_is_a HGNC:10871 ! ST8SIA4 +relationship: inverse_is_a HGNC:17827 ! ST8SIA5 +relationship: inverse_is_a HGNC:23317 ! ST8SIA6 + +[Term] +id: FPLX:000203 +name: GTF-family-90 +synonym: "Glycosyltransferase family 90" EXACT [] +synonym: "glycosyltransferase family 90" EXACT [] +is_a: FPLX:000198 ! Glycosyltransferase +relationship: inverse_is_a HGNC:19350 ! POGLUT2 +relationship: inverse_is_a HGNC:28496 ! POGLUT3 +relationship: inverse_is_a HGNC:22954 ! POGLUT1 + +[Term] +id: FPLX:000204 +name: GTPase +synonym: "GTPase" EXACT [] +xref: ECCODE:3.6.5.- +xref: MEDSCAN:urn:agi-complex:prophash-e9fbfd73e486bda4d99b348f72bb4196 +xref: NCIT:C16650 +is_a: FPLX:000000 ! famplex + +[Term] +id: FPLX:000205 +name: GUCY +synonym: "guanylate cyclase" EXACT [] +synonym: "guanylyl cyclase" EXACT [] +xref: BEL:"GUCY Family" +xref: ECCODE:4.6.1.2 +xref: NCIT:C16653 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:4688 ! GUCY2C +relationship: inverse_is_a HGNC:4689 ! GUCY2D +relationship: inverse_is_a HGNC:4691 ! GUCY2F +relationship: inverse_is_a HGNC:7943 ! NPR1 +relationship: inverse_is_a HGNC:7944 ! NPR2 + +[Term] +id: FPLX:000206 +name: GYS +synonym: "glycogen synthase" EXACT [] +xref: BEL:"GYS Family" +xref: IP:IPR008631 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:4706 ! GYS1 +relationship: inverse_is_a HGNC:4707 ! GYS2 + +[Term] +id: FPLX:000207 +name: G-12 +synonym: "G(12)" EXACT [] +synonym: "G12 family" EXACT [] +synonym: "G12 proteins" EXACT [] +synonym: "G12" EXACT [] +xref: IP:IPR000469 +xref: RE:R-HSA-114547 +xref: RE:R-HSA-418570 +xref: RE:R-HSA-418572 +is_a: FPLX:000214 ! G_protein +relationship: has_part FPLX:000208 ! G_12_alpha + +[Term] +id: FPLX:000208 +name: G-12-alpha +synonym: "G-protein alpha-12" EXACT [] +synonym: "G-protein α-12" EXACT [] +synonym: "Ga12" EXACT [] +synonym: "Galpha12" EXACT [] +synonym: "Gα12" EXACT [] +xref: IP:IPR000469 +xref: RE:R-HSA-114525 +xref: RE:R-HSA-418570 +xref: RE:R-HSA-418572 +is_a: FPLX:000209 ! G_alpha +relationship: part_of FPLX:000207 ! G_12 +relationship: inverse_is_a HGNC:4380 ! GNA12 +relationship: inverse_is_a HGNC:4381 ! GNA13 + +[Term] +id: FPLX:000209 +name: G-alpha +synonym: "G_alpha" EXACT [] +synonym: "G_α" EXACT [] +xref: XFAM:PF00503 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a FPLX:000213 ! G_i_alpha +relationship: inverse_is_a FPLX:000218 ! G_s_alpha +relationship: inverse_is_a FPLX:000216 ! G_q_alpha +relationship: inverse_is_a FPLX:000208 ! G_12_alpha + +[Term] +id: FPLX:000210 +name: G-beta +synonym: "G protein beta" EXACT [] +synonym: "G protein β" EXACT [] +synonym: "G-protein beta" EXACT [] +synonym: "G-protein β" EXACT [] +synonym: "Gbeta" EXACT [] +synonym: "Gβ" EXACT [] +xref: BEL:"GNB Family" +xref: IP:IPR016346 +xref: RE:R-HSA-167409 +xref: RE:R-HSA-400093 +xref: RE:R-HSA-6814207 +xref: RE:R-HSA-6814413 +xref: RE:R-HSA-8850524 +xref: SIGNOR:SIGNOR-PF4 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:4396 ! GNB1 +relationship: inverse_is_a HGNC:4398 ! GNB2 +relationship: inverse_is_a HGNC:4400 ! GNB3 +relationship: inverse_is_a HGNC:20731 ! GNB4 +relationship: inverse_is_a HGNC:4401 ! GNB5 + +[Term] +id: FPLX:000211 +name: G-gamma +synonym: "G protein gamma subunit" EXACT [] +synonym: "G protein gamma" EXACT [] +synonym: "G protein γ subunit" EXACT [] +synonym: "G protein γ" EXACT [] +xref: BEL:"GNG Family" +xref: IP:IPR001770 +xref: NEXTPROT-FAMILY:01400 +xref: RE:R-HSA-167442 +xref: RE:R-HSA-400062 +xref: SIGNOR:SIGNOR-PF3 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:4402 ! GNG10 +relationship: inverse_is_a HGNC:4403 ! GNG11 +relationship: inverse_is_a HGNC:19663 ! GNG12 +relationship: inverse_is_a HGNC:14131 ! GNG13 +relationship: inverse_is_a HGNC:4404 ! GNG2 +relationship: inverse_is_a HGNC:4405 ! GNG3 +relationship: inverse_is_a HGNC:4407 ! GNG4 +relationship: inverse_is_a HGNC:4408 ! GNG5 +relationship: inverse_is_a HGNC:4410 ! GNG7 +relationship: inverse_is_a HGNC:19664 ! GNG8 +relationship: inverse_is_a HGNC:4411 ! GNGT1 +relationship: inverse_is_a HGNC:4412 ! GNGT2 + +[Term] +id: FPLX:000212 +name: G-i +synonym: "Gi protein" EXACT [] +synonym: "Gi" EXACT [] +xref: BEL:"GNAI Family" +xref: IP:IPR001408 +xref: RE:R-HSA-111864 +xref: RE:R-HSA-167410 +xref: RE:R-HSA-167413 +xref: RE:R-HSA-167438 +is_a: FPLX:000214 ! G_protein +relationship: has_part FPLX:000213 ! G_i_alpha + +[Term] +id: FPLX:000213 +name: G-i-alpha +synonym: "G alphai" EXACT [] +synonym: "G αi" EXACT [] +synonym: "G-Protein alpha-i" EXACT [] +synonym: "G-Protein α-i" EXACT [] +synonym: "Galphai" EXACT [] +synonym: "Gi alpha subunit" EXACT [] +synonym: "Gi alpha" EXACT [] +synonym: "Gi α subunit" EXACT [] +synonym: "Gi α" EXACT [] +synonym: "Gαi" EXACT [] +xref: IP:IPR001408 +xref: NCIT:C19275 +xref: RE:R-HSA-111864 +xref: RE:R-HSA-167410 +xref: RE:R-HSA-167413 +xref: RE:R-HSA-167438 +is_a: FPLX:000209 ! G_alpha +relationship: part_of FPLX:000212 ! G_i +relationship: inverse_is_a HGNC:4389 ! GNAO1 +relationship: inverse_is_a HGNC:4384 ! GNAI1 +relationship: inverse_is_a HGNC:4385 ! GNAI2 +relationship: inverse_is_a HGNC:4387 ! GNAI3 +relationship: inverse_is_a HGNC:4393 ! GNAT1 +relationship: inverse_is_a HGNC:4394 ! GNAT2 +relationship: inverse_is_a HGNC:22800 ! GNAT3 +relationship: inverse_is_a HGNC:4395 ! GNAZ + +[Term] +id: FPLX:000214 +name: G-protein +synonym: "G protein" EXACT [] +synonym: "G proteins" EXACT [] +xref: NCIT:C17458 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a FPLX:000212 ! G_i +relationship: inverse_is_a FPLX:000217 ! G_s +relationship: inverse_is_a FPLX:000215 ! G_q +relationship: inverse_is_a FPLX:000207 ! G_12 + +[Term] +id: FPLX:000215 +name: G-q +synonym: "G(q/11)" EXACT [] +synonym: "Gq/11" EXACT [] +xref: BEL:"GNA Gq Family" +xref: IP:IPR000654 +xref: RE:R-HSA-114534 +xref: RE:R-HSA-114556 +xref: RE:R-HSA-374848 +xref: RE:R-HSA-399987 +xref: RE:R-HSA-399992 +xref: RE:R-HSA-400000 +xref: RE:R-HSA-400008 +xref: RE:R-HSA-749499 +is_a: FPLX:000214 ! G_protein +relationship: has_part FPLX:000216 ! G_q_alpha + +[Term] +id: FPLX:000216 +name: G-q-alpha +synonym: "G alphaq" EXACT [] +synonym: "G αq" EXACT [] +synonym: "G-Protein alpha-q" EXACT [] +synonym: "G-Protein α-q" EXACT [] +synonym: "Galphaq" EXACT [] +synonym: "Gq alpha subunit" EXACT [] +synonym: "Gq alpha" EXACT [] +synonym: "Gq α subunit" EXACT [] +synonym: "Gq α" EXACT [] +synonym: "Gαq" EXACT [] +xref: IP:IPR000654 +xref: RE:R-HSA-114534 +xref: RE:R-HSA-114556 +xref: RE:R-HSA-374848 +xref: RE:R-HSA-399987 +xref: RE:R-HSA-399992 +xref: RE:R-HSA-400000 +xref: RE:R-HSA-400008 +xref: RE:R-HSA-749499 +is_a: FPLX:000209 ! G_alpha +relationship: part_of FPLX:000215 ! G_q +relationship: inverse_is_a HGNC:4390 ! GNAQ +relationship: inverse_is_a HGNC:4379 ! GNA11 +relationship: inverse_is_a HGNC:4382 ! GNA14 +relationship: inverse_is_a HGNC:4383 ! GNA15 + +[Term] +id: FPLX:000217 +name: G-s +synonym: "G protein Gs" EXACT [] +synonym: "G protein(s)" EXACT [] +synonym: "G S protein" EXACT [] +synonym: "Gs family" EXACT [] +synonym: "Gs protein" EXACT [] +xref: BEL:"GNA Gs Family" +is_a: FPLX:000214 ! G_protein +relationship: has_part FPLX:000218 ! G_s_alpha + +[Term] +id: FPLX:000218 +name: G-s-alpha +synonym: "G alphaS" EXACT [] +synonym: "G αS" EXACT [] +synonym: "G-alpha(s)" EXACT [] +synonym: "G-AlphaS" EXACT [] +synonym: "G-Protein alpha-s" EXACT [] +synonym: "G-Protein α-s" EXACT [] +synonym: "G-α(s)" EXACT [] +synonym: "G-αS" EXACT [] +synonym: "GalphaS" EXACT [] +synonym: "Gs alpha subunit" EXACT [] +synonym: "Gs alpha" EXACT [] +synonym: "Gs α subunit" EXACT [] +synonym: "Gs α" EXACT [] +synonym: "GαS" EXACT [] +is_a: FPLX:000209 ! G_alpha +relationship: part_of FPLX:000217 ! G_s +relationship: inverse_is_a HGNC:4392 ! GNAS +relationship: inverse_is_a HGNC:4388 ! GNAL + +[Term] +id: FPLX:000219 +name: hCG +synonym: "hCG" EXACT [] +xref: NCIT:C2275 +xref: RE:R-HSA-378941 +is_a: FPLX:000000 ! famplex +relationship: has_part HGNC:1885 ! CGA +relationship: has_part HGNC:1886 ! CGB3 + +[Term] +id: FPLX:000220 +name: HDAC +synonym: "HDAC" EXACT [] +synonym: "histone deacetylase" EXACT [] +synonym: "histone deacetylases" EXACT [] +xref: BEL:"HDAC Family" +xref: ECCODE:3.5.1.98 +xref: IP:IPR003084 +xref: MEDSCAN:urn:agi-complex:prophash-7e8823afb9ca7870b95633dcb782500b +xref: NCIT:C16682 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a FPLX:000221 ! HDAC_I +relationship: inverse_is_a FPLX:000222 ! HDAC_II +relationship: inverse_is_a FPLX:000223 ! HDAC_III +relationship: inverse_is_a FPLX:000224 ! HDAC_IV + +[Term] +id: FPLX:000221 +name: HDAC-I +synonym: "Class I HDACs" EXACT [] +synonym: "class I HDACs" EXACT [] +synonym: "class I histone deacetylases" EXACT [] +xref: BEL:"HDAC Class I Family" +xref: IP:IPR003084 +is_a: FPLX:000220 ! HDAC +relationship: inverse_is_a HGNC:4852 ! HDAC1 +relationship: inverse_is_a HGNC:4853 ! HDAC2 +relationship: inverse_is_a HGNC:4854 ! HDAC3 +relationship: inverse_is_a HGNC:13315 ! HDAC8 + +[Term] +id: FPLX:000222 +name: HDAC-II +synonym: "class II HDACs" EXACT [] +synonym: "class II histone deacetylases" EXACT [] +xref: BEL:"HDAC Class II Family" +is_a: FPLX:000220 ! HDAC +relationship: inverse_is_a HGNC:14063 ! HDAC4 +relationship: inverse_is_a HGNC:14068 ! HDAC5 +relationship: inverse_is_a HGNC:14067 ! HDAC7 +relationship: inverse_is_a HGNC:14065 ! HDAC9 +relationship: inverse_is_a HGNC:14064 ! HDAC6 +relationship: inverse_is_a HGNC:18128 ! HDAC10 + +[Term] +id: FPLX:000223 +name: HDAC-III +synonym: "Class III HDACs" EXACT [] +synonym: "class III HDACs" EXACT [] +synonym: "class III histone deacetylases" EXACT [] +xref: IP:IPR003000 +xref: IP:IPR026590 +is_a: FPLX:000220 ! HDAC +relationship: inverse_is_a HGNC:14929 ! SIRT1 +relationship: inverse_is_a HGNC:10886 ! SIRT2 +relationship: inverse_is_a HGNC:14931 ! SIRT3 +relationship: inverse_is_a HGNC:14932 ! SIRT4 +relationship: inverse_is_a HGNC:14933 ! SIRT5 +relationship: inverse_is_a HGNC:14934 ! SIRT6 +relationship: inverse_is_a HGNC:14935 ! SIRT7 + +[Term] +id: FPLX:000224 +name: HDAC-IV +synonym: "Class IV HDACs" EXACT [] +synonym: "class IV HDACs" EXACT [] +synonym: "class IV histone deacetylases" EXACT [] +is_a: FPLX:000220 ! HDAC +relationship: inverse_is_a HGNC:19086 ! HDAC11 + +[Term] +id: FPLX:000225 +name: HDL +synonym: "HDL" EXACT [] +synonym: "High-density lipoproteins" EXACT [] +xref: BEL:"HDL Complex" +xref: GO:0034364 +xref: NCIT:C25186 +is_a: FPLX:000000 ! famplex +relationship: has_part HGNC:399 ! ALB +relationship: has_part HGNC:600 ! APOA1 +relationship: has_part HGNC:601 ! APOA2 +relationship: has_part HGNC:613 ! APOE +relationship: has_part HGNC:2095 ! CLU + +[Term] +id: FPLX:000226 +name: Hedgehog +synonym: "Hedgehog family" EXACT [] +synonym: "hedgehog protein" EXACT [] +synonym: "hedgehog signaling proteins" EXACT [] +synonym: "Hedgehog" EXACT [] +synonym: "Hh" EXACT [] +xref: BEL:"Hedgehog Family" +xref: IP:IPR000320 +xref: IP:IPR001657 +xref: IP:IPR001767 +xref: IP:IPR003586 +xref: IP:IPR003587 +xref: IP:IPR009045 +xref: IP:IPR028992 +xref: MEDSCAN:urn:agi-aopfc:0000587 +xref: NCIT:C120493 +xref: NEXTPROT-FAMILY:01729 +xref: RE:R-HSA-5358286 +xref: RE:R-HSA-5358318 +xref: RE:R-HSA-5358332 +xref: RE:R-HSA-5362382 +xref: RE:R-HSA-5362391 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:2865 ! DHH +relationship: inverse_is_a HGNC:5956 ! IHH +relationship: inverse_is_a HGNC:10848 ! SHH + +[Term] +id: FPLX:000227 +name: Hemoglobin +synonym: "hemoglobin" EXACT [] +xref: BEL:"Hemoglobin Complex" +xref: MEDSCAN:urn:agi-protfc:hemoglobin +xref: NCIT:C16676 +is_a: FPLX:000000 ! famplex +relationship: has_part HGNC:4823 ! HBA1 +relationship: has_part HGNC:4824 ! HBA2 +relationship: has_part HGNC:4827 ! HBB +relationship: has_part HGNC:4829 ! HBD +relationship: has_part HGNC:4830 ! HBE1 +relationship: has_part HGNC:4831 ! HBG1 +relationship: has_part HGNC:4832 ! HBG2 +relationship: has_part HGNC:4826 ! HBM +relationship: has_part HGNC:4833 ! HBQ1 +relationship: has_part HGNC:4835 ! HBZ + +[Term] +id: FPLX:000228 +name: HES +synonym: "Hes gene family" EXACT [] +synonym: "Hes genes" EXACT [] +synonym: "HES" EXACT [] +synonym: "Hes" EXACT [] +xref: BEL:"HES Family" +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:5192 ! HES1 +relationship: inverse_is_a HGNC:16005 ! HES2 +relationship: inverse_is_a HGNC:26226 ! HES3 +relationship: inverse_is_a HGNC:24149 ! HES4 +relationship: inverse_is_a HGNC:19764 ! HES5 +relationship: inverse_is_a HGNC:18254 ! HES6 +relationship: inverse_is_a HGNC:15977 ! HES7 + +[Term] +id: FPLX:000229 +name: HIF +synonym: "HIF" EXACT [] +synonym: "HIFs" EXACT [] +synonym: "hypoxia-inducible factors" EXACT [] +xref: NCIT:C113839 +xref: RE:R-HSA-1234130 +is_a: FPLX:000000 ! famplex +relationship: has_part FPLX:000231 ! HIF_alpha +relationship: has_part FPLX:000232 ! HIF_beta + +[Term] +id: FPLX:000230 +name: HIF1 +synonym: "HIF-1" EXACT [] +xref: MEDSCAN:urn:agi-complex:HIF-1 +xref: MEDSCAN:urn:agi-complex:prophash-44f61960049704dc2afb23ff7c324b85 +xref: NCIT:C17690 +xref: XFAM:PF11413 +is_a: FPLX:000000 ! famplex +relationship: has_part HGNC:4910 ! HIF1A +relationship: has_part HGNC:700 ! ARNT + +[Term] +id: FPLX:000231 +name: HIF-alpha +synonym: "HIFalpha" EXACT [] +synonym: "Hifalpha" EXACT [] +synonym: "HIFα" EXACT [] +synonym: "Hifα" EXACT [] +xref: RE:R-HSA-1234147 +relationship: part_of FPLX:000229 ! HIF +relationship: inverse_is_a HGNC:4910 ! HIF1A +relationship: inverse_is_a HGNC:3374 ! EPAS1 +relationship: inverse_is_a HGNC:15825 ! HIF3A + +[Term] +id: FPLX:000232 +name: HIF-beta +synonym: "HIFbeta" EXACT [] +synonym: "Hifbeta" EXACT [] +synonym: "HIFβ" EXACT [] +synonym: "Hifβ" EXACT [] +xref: RE:R-HSA-8936837 +relationship: part_of FPLX:000229 ! HIF +relationship: inverse_is_a HGNC:700 ! ARNT +relationship: inverse_is_a HGNC:16876 ! ARNT2 +relationship: inverse_is_a HGNC:701 ! ARNTL + +[Term] +id: FPLX:000233 +name: Histone +synonym: "Histone" EXACT [] +synonym: "histone" EXACT [] +synonym: "histones" EXACT [] +xref: BEL:"Histone Family" +xref: MEDSCAN:urn:agi-complex:prophash-0f8242e28423189d7ef714808fdcc121 +xref: MEDSCAN:urn:agi-protfc:histone +xref: MESH:D006657 +xref: NCIT:C16687 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a FPLX:000234 ! Histone_H1 +relationship: inverse_is_a FPLX:000235 ! Histone_H2A +relationship: inverse_is_a FPLX:000236 ! Histone_H2B +relationship: inverse_is_a FPLX:000237 ! Histone_H3 +relationship: inverse_is_a FPLX:000238 ! Histone_H4 + +[Term] +id: FPLX:000234 +name: Histone-H1 +synonym: "histone H1" EXACT [] +xref: BEL:"Histone H1 Family" +xref: MEDSCAN:urn:agi-protfc:histone%20H1 +xref: NCIT:C16683 +is_a: FPLX:000233 ! Histone +relationship: inverse_is_a HGNC:4714 ! H1F0 +relationship: inverse_is_a HGNC:18463 ! H1FOO +relationship: inverse_is_a HGNC:4722 ! H1FX +relationship: inverse_is_a HGNC:4715 ! HIST1H1A +relationship: inverse_is_a HGNC:4719 ! HIST1H1B +relationship: inverse_is_a HGNC:4716 ! HIST1H1C +relationship: inverse_is_a HGNC:4717 ! HIST1H1D +relationship: inverse_is_a HGNC:4718 ! HIST1H1E +relationship: inverse_is_a HGNC:4720 ! HIST1H1T +relationship: inverse_is_a HGNC:24893 ! H1FNT + +[Term] +id: FPLX:000235 +name: Histone-H2A +synonym: "Histone 2A" EXACT [] +synonym: "Histone H2A" EXACT [] +synonym: "histone H2A" EXACT [] +xref: BEL:"Histone H2A Family" +xref: MEDSCAN:urn:agi-protfc:histone%20H2A +xref: NCIT:C16684 +xref: NEXTPROT-FAMILY:01762 +is_a: FPLX:000233 ! Histone +relationship: inverse_is_a UP:H2A1_HUMAN ! P0C0S8 +relationship: inverse_is_a HGNC:22516 ! H2AFB1 +relationship: inverse_is_a UP:H2AB1_HUMAN ! P0C5Y9 +relationship: inverse_is_a HGNC:14456 ! H2AFJ +relationship: inverse_is_a HGNC:20664 ! H2AFV +relationship: inverse_is_a HGNC:4739 ! H2AFX +relationship: inverse_is_a HGNC:4740 ! H2AFY +relationship: inverse_is_a HGNC:14453 ! H2AFY2 +relationship: inverse_is_a HGNC:4741 ! H2AFZ +relationship: inverse_is_a HGNC:18729 ! HIST1H2AA +relationship: inverse_is_a HGNC:4733 ! HIST1H2AC +relationship: inverse_is_a HGNC:4729 ! HIST1H2AD +relationship: inverse_is_a HGNC:13671 ! HIST1H2AH +relationship: inverse_is_a HGNC:4727 ! HIST1H2AJ +relationship: inverse_is_a HGNC:20508 ! HIST2H2AB +relationship: inverse_is_a HGNC:4738 ! HIST2H2AC +relationship: inverse_is_a HGNC:20507 ! HIST3H2A +relationship: inverse_is_a UP:H2A1B_HUMAN ! P04908 +relationship: inverse_is_a UP:H2A2A_HUMAN ! Q6FI13 + +[Term] +id: FPLX:000236 +name: Histone-H2B +synonym: "H2B" EXACT [] +synonym: "histone H2B" EXACT [] +xref: BEL:"Histone H2B Family" +xref: MEDSCAN:urn:agi-protfc:histone%20H2B +is_a: FPLX:000233 ! Histone +relationship: inverse_is_a UP:H2B1C_HUMAN ! P62807 +relationship: inverse_is_a HGNC:18730 ! HIST1H2BA +relationship: inverse_is_a HGNC:4751 ! HIST1H2BB +relationship: inverse_is_a HGNC:4747 ! HIST1H2BD +relationship: inverse_is_a HGNC:4755 ! HIST1H2BH +relationship: inverse_is_a HGNC:4761 ! HIST1H2BJ +relationship: inverse_is_a HGNC:13954 ! HIST1H2BK +relationship: inverse_is_a HGNC:4748 ! HIST1H2BL +relationship: inverse_is_a HGNC:4750 ! HIST1H2BM +relationship: inverse_is_a HGNC:4749 ! HIST1H2BN +relationship: inverse_is_a HGNC:4758 ! HIST1H2BO +relationship: inverse_is_a HGNC:20516 ! HIST2H2BC +relationship: inverse_is_a HGNC:20517 ! HIST2H2BD +relationship: inverse_is_a HGNC:4760 ! HIST2H2BE +relationship: inverse_is_a HGNC:24700 ! HIST2H2BF +relationship: inverse_is_a HGNC:20514 ! HIST3H2BB +relationship: inverse_is_a HGNC:4762 ! H2BFS +relationship: inverse_is_a HGNC:27867 ! H2BFM +relationship: inverse_is_a HGNC:27252 ! H2BFWT + +[Term] +id: FPLX:000237 +name: Histone-H3 +synonym: "H3" EXACT [] +synonym: "histone H3" EXACT [] +synonym: "histone-3" EXACT [] +xref: BEL:"Histone H3 Family" +xref: IP:IPR000164 +xref: MEDSCAN:urn:agi-protfc:histone%20H3 +xref: NCIT:C16685 +xref: NEXTPROT-FAMILY:01764 +is_a: FPLX:000233 ! Histone +relationship: inverse_is_a UP:H31_HUMAN ! P68431 +relationship: inverse_is_a UP:H32_HUMAN ! Q71DI3 +relationship: inverse_is_a HGNC:4778 ! HIST3H3 +relationship: inverse_is_a UP:H33_HUMAN ! P84243 +relationship: inverse_is_a HGNC:33164 ! H3F3C + +[Term] +id: FPLX:000238 +name: Histone-H4 +synonym: "histone H4" EXACT [] +xref: BEL:"Histone H4 Family" +xref: IP:IPR001951 +xref: MEDSCAN:urn:agi-protfc:histone%20H4 +xref: NCIT:C16686 +xref: NEXTPROT-FAMILY:01765 +is_a: FPLX:000233 ! Histone +relationship: inverse_is_a UP:H4_HUMAN ! P62805 +relationship: inverse_is_a HGNC:4792 ! HIST1H4G + +[Term] +id: FPLX:000239 +name: HLA-DR +synonym: "HLA-DR" EXACT [] +xref: BEL:"HLA-DR Family" +xref: NCIT:C16692 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:4947 ! HLA-DRA +relationship: inverse_is_a HGNC:4948 ! HLA-DRB1 +relationship: inverse_is_a HGNC:4951 ! HLA-DRB3 +relationship: inverse_is_a HGNC:4952 ! HLA-DRB4 +relationship: inverse_is_a HGNC:4953 ! HLA-DRB5 + +[Term] +id: FPLX:000240 +name: HMOX +synonym: "haem oxygenase" EXACT [] +synonym: "heme oxygenase" EXACT [] +xref: BEL:"HMOX Family" +xref: ECCODE:1.14.99.3 +xref: IP:IPR002051 +xref: IP:IPR016053 +xref: IP:IPR016084 +xref: IP:IPR018207 +xref: RE:R-HSA-189382 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:5013 ! HMOX1 +relationship: inverse_is_a HGNC:5014 ! HMOX2 + +[Term] +id: FPLX:000241 +name: HSP90 +synonym: "HSP90" EXACT [] +synonym: "Hsp90" EXACT [] +xref: BEL:"HSP90 Family" +xref: NCIT:C17766 +xref: XFAM:PF00183 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a FPLX:000242 ! HSP90A +relationship: inverse_is_a HGNC:12028 ! HSP90B1 +relationship: inverse_is_a HGNC:16264 ! TRAP1 + +[Term] +id: FPLX:000242 +name: HSP90A +synonym: "HSP90A" EXACT [] +xref: RE:R-HSA-3371429 +xref: RE:R-HSA-419619 +xref: RE:R-HSA-5082395 +xref: RE:R-HSA-5618088 +is_a: FPLX:000241 ! HSP90 +relationship: inverse_is_a FPLX:000243 ! HSP90AA +relationship: inverse_is_a HGNC:5258 ! HSP90AB1 + +[Term] +id: FPLX:000243 +name: HSP90AA +synonym: "HSP90AA" EXACT [] +xref: RE:R-HSA-1218829 +xref: RE:R-HSA-1221657 +xref: RE:R-HSA-5082406 +is_a: FPLX:000242 ! HSP90A +relationship: inverse_is_a HGNC:5253 ! HSP90AA1 + +[Term] +id: FPLX:000244 +name: HSPA +synonym: "Heat Shock Protein 70" EXACT [] +synonym: "HSP70" EXACT [] +synonym: "Hsp70" EXACT [] +xref: BEL:"HSPA Family" +xref: XFAM:PF00012 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:19022 ! HSPA12A +relationship: inverse_is_a HGNC:16193 ! HSPA12B +relationship: inverse_is_a HGNC:11375 ! HSPA13 +relationship: inverse_is_a HGNC:29526 ! HSPA14 +relationship: inverse_is_a HGNC:5232 ! HSPA1A +relationship: inverse_is_a HGNC:5233 ! HSPA1B +relationship: inverse_is_a HGNC:5234 ! HSPA1L +relationship: inverse_is_a HGNC:5235 ! HSPA2 +relationship: inverse_is_a HGNC:5237 ! HSPA4 +relationship: inverse_is_a HGNC:17041 ! HSPA4L +relationship: inverse_is_a HGNC:5238 ! HSPA5 +relationship: inverse_is_a HGNC:5239 ! HSPA6 +relationship: inverse_is_a HGNC:5241 ! HSPA8 +relationship: inverse_is_a HGNC:5244 ! HSPA9 +relationship: inverse_is_a HGNC:16969 ! HSPH1 +relationship: inverse_is_a HGNC:16931 ! HYOU1 + +[Term] +id: FPLX:000245 +name: HSPB +synonym: "heat shock protein family B" EXACT [] +synonym: "HSPB proteins" EXACT [] +synonym: "HSPB" EXACT [] +synonym: "small HSPs" EXACT [] +xref: BEL:"HSPB Family" +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:5246 ! HSPB1 +relationship: inverse_is_a HGNC:5247 ! HSPB2 +relationship: inverse_is_a HGNC:30171 ! HSPB8 + +[Term] +id: FPLX:000246 +name: IFNA +synonym: "IFN-a" EXACT [] +synonym: "IFN-alpha" EXACT [] +synonym: "IFN-α" EXACT [] +synonym: "IFNalpha" EXACT [] +synonym: "IFNα" EXACT [] +xref: BEL:"IFNA Family" +xref: RE:R-HSA-909688 +is_a: FPLX:000262 ! Interferon +relationship: inverse_is_a HGNC:5417 ! IFNA1 +relationship: inverse_is_a HGNC:5423 ! IFNA2 +relationship: inverse_is_a HGNC:5425 ! IFNA4 +relationship: inverse_is_a HGNC:5426 ! IFNA5 +relationship: inverse_is_a HGNC:5427 ! IFNA6 +relationship: inverse_is_a HGNC:5428 ! IFNA7 +relationship: inverse_is_a HGNC:5429 ! IFNA8 +relationship: inverse_is_a HGNC:5418 ! IFNA10 +relationship: inverse_is_a HGNC:5419 ! IFNA13 +relationship: inverse_is_a HGNC:5420 ! IFNA14 +relationship: inverse_is_a HGNC:5421 ! IFNA16 +relationship: inverse_is_a HGNC:5422 ! IFNA17 +relationship: inverse_is_a HGNC:5424 ! IFNA21 + +[Term] +id: FPLX:000247 +name: IFNB +synonym: "beta interferons" EXACT [] +synonym: "IFN-beta" EXACT [] +synonym: "IFN-β" EXACT [] +synonym: "Interferon beta" EXACT [] +synonym: "interferon beta" EXACT [] +synonym: "Interferon β" EXACT [] +synonym: "interferon β" EXACT [] +synonym: "β interferons" EXACT [] +xref: IP:IPR015588 +xref: NCIT:C20495 +is_a: FPLX:000262 ! Interferon +relationship: inverse_is_a HGNC:5434 ! IFNB1 + +[Term] +id: FPLX:000248 +name: IGFBP +synonym: "IGF-BP" EXACT [] +synonym: "IGFBP" EXACT [] +synonym: "IGFBPs" EXACT [] +synonym: "insulin-like growth factor binding proteins" EXACT [] +xref: BEL:"IGFBP Family" +xref: MEDSCAN:urn:agi-aopfc:0000586 +xref: XFAM:PF00219 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:5469 ! IGFBP1 +relationship: inverse_is_a HGNC:5471 ! IGFBP2 +relationship: inverse_is_a HGNC:5472 ! IGFBP3 +relationship: inverse_is_a HGNC:5473 ! IGFBP4 +relationship: inverse_is_a HGNC:5474 ! IGFBP5 +relationship: inverse_is_a HGNC:5475 ! IGFBP6 +relationship: inverse_is_a HGNC:5476 ! IGFBP7 + +[Term] +id: FPLX:000249 +name: IKB +synonym: "IkappaB" EXACT [] +synonym: "IκB" EXACT [] +xref: NCIT:C17583 +is_a: FPLX:000000 ! famplex + +[Term] +id: FPLX:000250 +name: IKK-complex +synonym: "IKK complex" EXACT [] +xref: BEL:"IkappaB Kinase Complex" +xref: MEDSCAN:urn:agi-complex:IKK%20complex +xref: RE:R-HSA-1168621 +xref: RE:R-HSA-168113 +xref: RE:R-HSA-177663 +xref: RE:R-HSA-202513 +xref: RE:R-HSA-202562 +xref: RE:R-HSA-5262981 +xref: RE:R-HSA-727820 +is_a: FPLX:000000 ! famplex +relationship: has_part HGNC:1974 ! CHUK +relationship: has_part HGNC:5960 ! IKBKB +relationship: has_part HGNC:5961 ! IKBKG + +[Term] +id: FPLX:000251 +name: IKK-family +synonym: "IkappaB kinase" EXACT [] +synonym: "IKK" EXACT [] +synonym: "IκB kinase" EXACT [] +xref: BEL:"IkappaB Kinase Family" +xref: NCIT:C104199 +xref: NEXTPROT-FAMILY:03104 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:1974 ! CHUK +relationship: inverse_is_a HGNC:5960 ! IKBKB +relationship: inverse_is_a HGNC:5961 ! IKBKG +relationship: inverse_is_a HGNC:14552 ! IKBKE +relationship: inverse_is_a HGNC:11584 ! TBK1 + +[Term] +id: FPLX:000252 +name: IL1 +synonym: "IL-1" EXACT [] +synonym: "IL1 family" EXACT [] +xref: BEL:"IL1 Family" +xref: IP:IPR003502 +xref: MEDSCAN:urn:agi-aopfc:0000615 +xref: NCIT:C20506 +xref: NEXTPROT-FAMILY:01820 +xref: XFAM:PF00340 +xref: RE:R-HSA-445744 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:5991 ! IL1A +relationship: inverse_is_a HGNC:5992 ! IL1B + +[Term] +id: FPLX:000253 +name: IL12 +synonym: "IL-12" EXACT [] +synonym: "IL12" EXACT [] +xref: MEDSCAN:urn:agi-complex:IL12 +xref: NCIT:C20514 +xref: XFAM:PF03039 +xref: RE:R-HSA-447102 +xref: RE:R-HSA-8950122 +xref: RE:R-HSA-8950228 +xref: RE:R-HSA-8950694 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:5969 ! IL12A +relationship: inverse_is_a HGNC:5970 ! IL12B + +[Term] +id: FPLX:000254 +name: IL15R +synonym: "IL-15 receptor" EXACT [] +synonym: "IL-15R" EXACT [] +is_a: FPLX:000000 ! famplex +relationship: has_part HGNC:5978 ! IL15RA +relationship: has_part HGNC:6009 ! IL2RB +relationship: has_part HGNC:6010 ! IL2RG + +[Term] +id: FPLX:000255 +name: IL2R +synonym: "IL-2 receptor" EXACT [] +synonym: "IL-2R" EXACT [] +is_a: FPLX:000000 ! famplex +relationship: has_part HGNC:6008 ! IL2RA +relationship: has_part HGNC:6009 ! IL2RB +relationship: has_part HGNC:6010 ! IL2RG + +[Term] +id: FPLX:000256 +name: Inhibin +synonym: "Inhibin" EXACT [] +synonym: "inhibin" EXACT [] +xref: GO:0043511 +xref: NCIT:C2276 +xref: RE:R-HSA-1449688 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a FPLX:000257 ! Inhibin_A +relationship: inverse_is_a FPLX:000258 ! Inhibin_B + +[Term] +id: FPLX:000257 +name: Inhibin-A +synonym: "inhibin A" EXACT [] +synonym: "inhibin-A" EXACT [] +synonym: "inhibin-a" EXACT [] +xref: MEDSCAN:urn:agi-complex:inhibin%20A +xref: NCIT:C2277 +is_a: FPLX:000256 ! Inhibin +relationship: has_part HGNC:6065 ! INHA +relationship: has_part HGNC:6066 ! INHBA + +[Term] +id: FPLX:000258 +name: Inhibin-B +synonym: "inhibin B" EXACT [] +synonym: "inhibin-B" EXACT [] +synonym: "inhibin-b" EXACT [] +xref: NCIT:C2278 +is_a: FPLX:000256 ! Inhibin +relationship: has_part HGNC:6065 ! INHA +relationship: has_part HGNC:6067 ! INHBB + +[Term] +id: FPLX:000259 +name: INS +synonym: "insulin family" EXACT [] +xref: BEL:"INS Family" +xref: NEXTPROT-FAMILY:01869 +xref: RE:R-HSA-429349 +xref: RE:R-HSA-429352 +xref: RE:R-HSA-429384 +xref: RE:R-HSA-429407 +xref: RE:R-HSA-429472 +xref: RE:R-HSA-74674 +xref: RE:R-HSA-77385 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:6081 ! INS + +[Term] +id: FPLX:000260 +name: INSR +synonym: "Insulin receptor family" EXACT [] +synonym: "insulin receptor family" EXACT [] +synonym: "insulin receptor/insulin-like growth factor receptor family" EXACT [] +xref: BEL:"INSR Family" +xref: IP:IPR016246 +xref: MEDSCAN:urn:agi-aopfc:0000264 +xref: NEXTPROT-FAMILY:03128 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:5465 ! IGF1R +relationship: inverse_is_a HGNC:6091 ! INSR +relationship: inverse_is_a HGNC:6093 ! INSRR + +[Term] +id: FPLX:000261 +name: Integrins +synonym: "alpha2beta1 integrin" EXACT [] +synonym: "integrin" EXACT [] +synonym: "integrins" EXACT [] +synonym: "LFA-1 (integrin)" EXACT [] +synonym: "MAC-1 (integrin)" EXACT [] +synonym: "vitronectin receptor (integrin)" EXACT [] +xref: GO:0034666 +xref: GO:0034683 +xref: GO:0034687 +xref: MEDSCAN:urn:agi-complex:MAC-1%20(integrin) +xref: NCIT:C16748 +is_a: FPLX:000000 ! famplex + +[Term] +id: FPLX:000262 +name: Interferon +synonym: "IFN" EXACT [] +synonym: "interferon" EXACT [] +xref: MEDSCAN:urn:agi-protfc:interferon +xref: NCIT:C20493 +xref: XFAM:PF00143 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a FPLX:000246 ! IFNA +relationship: inverse_is_a FPLX:000247 ! IFNB +relationship: inverse_is_a HGNC:21714 ! IFNK +relationship: inverse_is_a HGNC:5448 ! IFNW1 + +[Term] +id: FPLX:000263 +name: Interferon-gamma-receptor +synonym: "IFNGR" EXACT [] +synonym: "interferon gamma receptor" EXACT [] +synonym: "interferon γ receptor" EXACT [] +synonym: "interferon-gamma receptor" EXACT [] +synonym: "interferon-γ receptor" EXACT [] +xref: BEL:"Interferon Gamma Receptor Complex" +xref: MEDSCAN:urn:agi-complex:IFNGR +is_a: FPLX:000000 ! famplex +relationship: has_part HGNC:5439 ! IFNGR1 +relationship: has_part HGNC:5440 ! IFNGR2 + +[Term] +id: FPLX:000264 +name: IRS +synonym: "insulin receptor substrate" EXACT [] +synonym: "IRS family" EXACT [] +synonym: "IRS" EXACT [] +xref: BEL:"IRS Family" +xref: MEDSCAN:urn:agi-aopfc:0000585 +xref: XFAM:PF02174 +xref: RE:R-HSA-2445131 +xref: RE:R-HSA-2445139 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:6125 ! IRS1 +relationship: inverse_is_a HGNC:6126 ! IRS2 +relationship: inverse_is_a HGNC:6128 ! IRS4 + +[Term] +id: FPLX:000265 +name: IRX +synonym: "homeodomain iroquois proteins" EXACT [] +synonym: "Iroquois family" EXACT [] +synonym: "Iroquois proteins" EXACT [] +synonym: "Iroquois-class homeodomain proteins" EXACT [] +xref: BEL:"IRX Family" +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:14358 ! IRX1 +relationship: inverse_is_a HGNC:14359 ! IRX2 +relationship: inverse_is_a HGNC:14360 ! IRX3 +relationship: inverse_is_a HGNC:6129 ! IRX4 +relationship: inverse_is_a HGNC:14361 ! IRX5 +relationship: inverse_is_a HGNC:14675 ! IRX6 +relationship: inverse_is_a HGNC:23729 ! MKX + +[Term] +id: FPLX:000266 +name: JAK +synonym: "JAK" EXACT [] +synonym: "Jak" EXACT [] +synonym: "JAKs" EXACT [] +xref: BEL:"JAK Family" +xref: IP:IPR016251 +xref: MEDSCAN:urn:agi-aopfc:0000464 +xref: NEXTPROT-FAMILY:03129 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:6190 ! JAK1 +relationship: inverse_is_a HGNC:6192 ! JAK2 +relationship: inverse_is_a HGNC:6193 ! JAK3 +relationship: inverse_is_a HGNC:12440 ! TYK2 + +[Term] +id: FPLX:000267 +name: JNK +synonym: "c-JNK" EXACT [] +synonym: "c-Jun N-terminal kinase" EXACT [] +synonym: "c-Jun NH2-terminal kinase" EXACT [] +synonym: "JNK MAPK" EXACT [] +synonym: "JNK" EXACT [] +synonym: "JNK1/2" EXACT [] +synonym: "JNKs" EXACT [] +xref: BEL:"MAPK JNK Family" +xref: IP:IPR008351 +xref: MEDSCAN:urn:agi-aopfc:0000473 +xref: RE:R-HSA-450226 +xref: RE:R-HSA-450253 +xref: RE:R-HSA-450289 +xref: SIGNOR:SIGNOR-PF15 +is_a: FPLX:000283 ! MAPK +relationship: inverse_is_a HGNC:6881 ! MAPK8 +relationship: inverse_is_a HGNC:6886 ! MAPK9 +relationship: inverse_is_a HGNC:6872 ! MAPK10 + +[Term] +id: FPLX:000268 +name: JUN-family +synonym: "JUN" EXACT [] +xref: IP:IPR002112 +xref: IP:IPR005643 +xref: MEDSCAN:urn:agi-complex:prophash-8d885376e30916afd0b47ccf1b044e75 +relationship: part_of FPLX:000048 ! AP1 +relationship: inverse_is_a HGNC:6204 ! JUN +relationship: inverse_is_a HGNC:6205 ! JUNB +relationship: inverse_is_a HGNC:6206 ! JUND + +[Term] +id: FPLX:000269 +name: Kainate-family +synonym: "Glutamate receptors, ionotropic, kainate" EXACT [] +synonym: "Kainate receptors" EXACT [] +synonym: "KARs" EXACT [] +xref: GFAM:1199 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:4579 ! GRIK1 +relationship: inverse_is_a HGNC:4580 ! GRIK2 +relationship: inverse_is_a HGNC:4581 ! GRIK3 +relationship: inverse_is_a HGNC:4582 ! GRIK4 +relationship: inverse_is_a HGNC:4583 ! GRIK5 + +[Term] +id: FPLX:000270 +name: Kinetochore +synonym: "kinetochore complex" EXACT [] +synonym: "kinetochore" EXACT [] +synonym: "kinetochores" EXACT [] +xref: BEL:"Kinetochore Complex" +xref: GO:0000776 +is_a: FPLX:000000 ! famplex +relationship: has_part HGNC:1148 ! BUB1 +relationship: has_part HGNC:1149 ! BUB1B +relationship: has_part HGNC:1151 ! BUB3 +relationship: has_part HGNC:1854 ! CENPC +relationship: has_part HGNC:1856 ! CENPE +relationship: has_part HGNC:1857 ! CENPF +relationship: has_part HGNC:17268 ! CENPH +relationship: has_part HGNC:2712 ! DCTN2 +relationship: has_part HGNC:6391 ! KIF22 +relationship: has_part HGNC:6763 ! MAD2L1 +relationship: has_part HGNC:8574 ! PAFAH1B1 +relationship: has_part HGNC:9508 ! PSEN1 +relationship: has_part HGNC:9509 ! PSEN2 +relationship: has_part HGNC:11111 ! SMC1A +relationship: has_part HGNC:16987 ! SUGT1 +relationship: has_part HGNC:11124 ! SUMO3 +relationship: has_part HGNC:13194 ! ZW10 + +[Term] +id: FPLX:000271 +name: KLK +synonym: "kallikrein" EXACT [] +synonym: "kallikrein-related peptidases" EXACT [] +synonym: "KLKs" EXACT [] +synonym: "tissue kallikrein" EXACT [] +synonym: "tissue kallikreins" EXACT [] +xref: BEL:"KLK Family" +xref: ECCODE:3.4.21.35 +xref: MEDSCAN:urn:agi-protfc:kallikrein +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:6357 ! KLK1 +relationship: inverse_is_a HGNC:6358 ! KLK10 +relationship: inverse_is_a HGNC:6359 ! KLK11 +relationship: inverse_is_a HGNC:6360 ! KLK12 +relationship: inverse_is_a HGNC:6361 ! KLK13 +relationship: inverse_is_a HGNC:6362 ! KLK14 +relationship: inverse_is_a HGNC:20453 ! KLK15 +relationship: inverse_is_a HGNC:6363 ! KLK2 +relationship: inverse_is_a HGNC:6364 ! KLK3 +relationship: inverse_is_a HGNC:6365 ! KLK4 +relationship: inverse_is_a HGNC:6366 ! KLK5 +relationship: inverse_is_a HGNC:6367 ! KLK6 +relationship: inverse_is_a HGNC:6368 ! KLK7 +relationship: inverse_is_a HGNC:6369 ! KLK8 +relationship: inverse_is_a HGNC:6370 ! KLK9 +relationship: inverse_is_a HGNC:6371 ! KLKB1 + +[Term] +id: FPLX:000272 +name: KSR +synonym: "KSR" EXACT [] +xref: IP:IPR025561 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:6465 ! KSR1 +relationship: inverse_is_a HGNC:18610 ! KSR2 + +[Term] +id: FPLX:000273 +name: Laminin-111 +synonym: "LM-1" EXACT [] +xref: BEL:"Laminin 1 Complex" +xref: RE:R-HSA-215989 +xref: RE:R-HSA-2426371 +is_a: FPLX:000000 ! famplex +relationship: has_part HGNC:6481 ! LAMA1 +relationship: has_part HGNC:6486 ! LAMB1 +relationship: has_part HGNC:6492 ! LAMC1 + +[Term] +id: FPLX:000274 +name: Laminin-332 +synonym: "laminin 332 chains" EXACT [] +synonym: "laminin 332" EXACT [] +synonym: "laminin-332 chains" EXACT [] +synonym: "laminin-332" EXACT [] +synonym: "Laminin-5" EXACT [] +synonym: "laminin-5" EXACT [] +xref: BEL:"Laminin 5 Complex" +xref: GO:0005610 +xref: RE:R-HSA-216001 +xref: RE:R-HSA-2220790 +xref: RE:R-HSA-2399659 +xref: RE:R-HSA-2533911 +is_a: FPLX:000000 ! famplex +relationship: has_part HGNC:6483 ! LAMA3 +relationship: has_part HGNC:6490 ! LAMB3 +relationship: has_part HGNC:6493 ! LAMC2 + +[Term] +id: FPLX:000275 +name: LDH +synonym: "LDH" EXACT [] +xref: BEL:"LDH Family" +xref: NCIT:C25184 +xref: NEXTPROT-FAMILY:02022 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:6535 ! LDHA +relationship: inverse_is_a HGNC:6541 ! LDHB +relationship: inverse_is_a HGNC:6544 ! LDHC + +[Term] +id: FPLX:000276 +name: LH +synonym: "LH" EXACT [] +synonym: "Luteinizing hormone" EXACT [] +synonym: "luteinizing hormone" EXACT [] +synonym: "luteinizing-hormone" EXACT [] +xref: BEL:"Luteinizing Hormone Complex" +xref: MEDSCAN:urn:agi-complex:Luteinizing%20hormone +xref: RE:R-HSA-378969 +xref: RE:R-HSA-6793931 +xref: RE:R-HSA-6793934 +is_a: FPLX:000000 ! famplex +relationship: has_part HGNC:1885 ! CGA +relationship: has_part HGNC:6584 ! LHB + +[Term] +id: FPLX:000277 +name: LPAR +xref: SIGNOR:SIGNOR-PF2 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:3166 ! LPAR1 +relationship: inverse_is_a HGNC:3168 ! LPAR2 +relationship: inverse_is_a HGNC:14298 ! LPAR3 + +[Term] +id: FPLX:000278 +name: MAC +synonym: "MAC" EXACT [] +synonym: "membrane attack complex" EXACT [] +synonym: "membrane attack" EXACT [] +xref: BEL:"Membrane Attack Complex" +xref: GO:0005579 +xref: RE:R-HSA-173728 +xref: RE:R-HSA-8852568 +is_a: FPLX:000000 ! famplex +relationship: has_part HGNC:1331 ! C5 +relationship: has_part HGNC:1339 ! C6 +relationship: has_part HGNC:1346 ! C7 +relationship: has_part HGNC:1352 ! C8A +relationship: has_part HGNC:1353 ! C8B +relationship: has_part HGNC:1354 ! C8G +relationship: has_part HGNC:1358 ! C9 + +[Term] +id: FPLX:000279 +name: MAF +synonym: "Maf subfamily" EXACT [] +synonym: "MAF" EXACT [] +synonym: "Maf" EXACT [] +synonym: "maf" EXACT [] +xref: BEL:"MAF Family" +xref: IP:IPR004826 +xref: MEDSCAN:urn:agi-aopfc:0000142 +xref: XFAM:PF02545 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:6776 ! MAF +relationship: inverse_is_a HGNC:23145 ! MAFA +relationship: inverse_is_a HGNC:6408 ! MAFB +relationship: inverse_is_a HGNC:6780 ! MAFF +relationship: inverse_is_a HGNC:6781 ! MAFG +relationship: inverse_is_a HGNC:6782 ! MAFK + +[Term] +id: FPLX:000280 +name: MAP1LC3 +synonym: "LC3" EXACT [] +xref: IP:IPR004241 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:6838 ! MAP1LC3A +relationship: inverse_is_a HGNC:13352 ! MAP1LC3B +relationship: inverse_is_a HGNC:34390 ! MAP1LC3B2 +relationship: inverse_is_a HGNC:13353 ! MAP1LC3C + +[Term] +id: FPLX:000281 +name: MAP2K +synonym: "MAPK kinase" EXACT [] +synonym: "mitogen-activated protein kinase kinase" EXACT [] +xref: NCIT:C105947 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a FPLX:000286 ! MEK +relationship: inverse_is_a HGNC:6843 ! MAP2K3 +relationship: inverse_is_a HGNC:6844 ! MAP2K4 +relationship: inverse_is_a HGNC:6845 ! MAP2K5 +relationship: inverse_is_a HGNC:6846 ! MAP2K6 +relationship: inverse_is_a HGNC:6847 ! MAP2K7 + +[Term] +id: FPLX:000282 +name: MAP3K +synonym: "MAP3K" EXACT [] +synonym: "MAPK kinase kinase" EXACT [] +synonym: "MAPKK kinases" EXACT [] +synonym: "MAPKKK" EXACT [] +xref: ECCODE:2.7.11.25 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a FPLX:000399 ! RAF +relationship: inverse_is_a HGNC:6848 ! MAP3K1 +relationship: inverse_is_a HGNC:6854 ! MAP3K2 +relationship: inverse_is_a HGNC:6855 ! MAP3K3 +relationship: inverse_is_a HGNC:6856 ! MAP3K4 +relationship: inverse_is_a HGNC:6857 ! MAP3K5 +relationship: inverse_is_a HGNC:6858 ! MAP3K6 +relationship: inverse_is_a HGNC:6859 ! MAP3K7 +relationship: inverse_is_a HGNC:6860 ! MAP3K8 +relationship: inverse_is_a HGNC:6861 ! MAP3K9 +relationship: inverse_is_a HGNC:6849 ! MAP3K10 +relationship: inverse_is_a HGNC:6850 ! MAP3K11 +relationship: inverse_is_a HGNC:6851 ! MAP3K12 +relationship: inverse_is_a HGNC:6852 ! MAP3K13 +relationship: inverse_is_a HGNC:6853 ! MAP3K14 +relationship: inverse_is_a HGNC:31689 ! MAP3K15 +relationship: inverse_is_a FPLX:000458 ! TAOK +relationship: inverse_is_a HGNC:26249 ! MAP3K19 +relationship: inverse_is_a HGNC:17797 ! MAP3K20 +relationship: inverse_is_a HGNC:29798 ! MAP3K21 + +[Term] +id: FPLX:000283 +name: MAPK +synonym: "MAP kinase" EXACT [] +synonym: "MAP kinases" EXACT [] +synonym: "MAPKs" EXACT [] +synonym: "mitogen activated protein kinase" EXACT [] +synonym: "mitogen activated protein kinases" EXACT [] +synonym: "mitogen-activated protein kinase" EXACT [] +synonym: "mitogen-activated protein kinases" EXACT [] +xref: ECCODE:2.7.11.24 +xref: ECCODE:2.7.12.2 +xref: NCIT:C16376 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a FPLX:000161 ! ERK +relationship: inverse_is_a FPLX:000326 ! p38 +relationship: inverse_is_a FPLX:000267 ! JNK + +[Term] +id: FPLX:000284 +name: MCM +synonym: "MCM" EXACT [] +synonym: "mini-chromosome maintenance complex" EXACT [] +synonym: "minichromosome maintenance complex" EXACT [] +synonym: "minichromosome maintenance protein complex" EXACT [] +xref: GO:0042555 +xref: IP:IPR001208 +xref: IP:IPR031327 +xref: MEDSCAN:urn:agi-complex:prophash-e6be10f6a8e79aed1daa4ec2ac191db1 +xref: NEXTPROT-FAMILY:02187 +xref: XFAM:PF00493 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:6944 ! MCM2 +relationship: inverse_is_a HGNC:6945 ! MCM3 +relationship: inverse_is_a HGNC:6947 ! MCM4 +relationship: inverse_is_a HGNC:6948 ! MCM5 +relationship: inverse_is_a HGNC:6949 ! MCM6 +relationship: inverse_is_a HGNC:6950 ! MCM7 +relationship: inverse_is_a HGNC:16147 ! MCM8 +relationship: inverse_is_a HGNC:21484 ! MCM9 +relationship: inverse_is_a HGNC:26368 ! MCMDC2 + +[Term] +id: FPLX:000285 +name: MEF2 +synonym: "MEF2 family" EXACT [] +synonym: "MEF2" EXACT [] +xref: BEL:"MEF2 Family" +xref: IP:IPR033896 +xref: MEDSCAN:urn:agi-aopfc:0000143 +xref: RE:R-HSA-448866 +xref: RE:R-HSA-448868 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:6993 ! MEF2A +relationship: inverse_is_a HGNC:6996 ! MEF2C +relationship: inverse_is_a HGNC:6997 ! MEF2D +relationship: inverse_is_a HGNC:6995 ! MEF2B + +[Term] +id: FPLX:000286 +name: MEK +synonym: "MEK 1/2" EXACT [] +synonym: "MEK" EXACT [] +synonym: "MEK1/2" EXACT [] +xref: BEL:"MEK1/2 Family" +xref: MEDSCAN:urn:agi-aopfc:0000462 +xref: RE:R-HSA-5672686 +xref: RE:R-HSA-5672705 +xref: RE:R-HSA-5672716 +xref: RE:R-HSA-5672721 +xref: RE:R-HSA-5674489 +xref: SIGNOR:SIGNOR-PF25 +is_a: FPLX:000281 ! MAP2K +relationship: inverse_is_a HGNC:6840 ! MAP2K1 +relationship: inverse_is_a HGNC:6842 ! MAP2K2 + +[Term] +id: FPLX:000287 +name: MGAT +synonym: "MGAT" EXACT [] +is_a: FPLX:000198 ! Glycosyltransferase +relationship: inverse_is_a HGNC:7044 ! MGAT1 +relationship: inverse_is_a HGNC:7045 ! MGAT2 +relationship: inverse_is_a HGNC:7046 ! MGAT3 +relationship: inverse_is_a HGNC:7047 ! MGAT4A +relationship: inverse_is_a HGNC:7048 ! MGAT4B +relationship: inverse_is_a HGNC:30871 ! MGAT4C +relationship: inverse_is_a HGNC:43619 ! MGAT4D +relationship: inverse_is_a HGNC:7049 ! MGAT5 +relationship: inverse_is_a HGNC:24140 ! MGAT5B + +[Term] +id: FPLX:000288 +name: Mitochondrial-Ribosome +synonym: "mammalian mitochondrial ribosome" EXACT [] +synonym: "Mitochondrial ribosome" EXACT [] +synonym: "Mitochondrial Ribosome" EXACT [] +synonym: "mitochondrial ribosomes" EXACT [] +synonym: "Mitochondrial ribosomes" EXACT [] +synonym: "Mitochondrial Ribosomes" EXACT [] +synonym: "mitoribosome" EXACT [] +synonym: "Mitoribosome" EXACT [] +synonym: "55S mammalian mitochondrial ribosome" EXACT [] +synonym: "55S mitoribosome" EXACT [] +synonym: "55s mitoribosome" EXACT [] +synonym: "55S Mitoribosome" EXACT [] +synonym: "55s Mitoribosome" EXACT [] +xref: GO:0005761 +is_a: FPLX:000000 ! famplex +relationship: has_part FPLX:000289 ! MRPS +relationship: has_part FPLX:000290 ! MRPL + +[Term] +id: FPLX:000289 +name: MRPS +synonym: "small mitoribosomal subunit" EXACT [] +synonym: "Small Mitoribosomal Subunit" EXACT [] +synonym: "small subunit of the mammalian mitochondrial ribosome" EXACT [] +synonym: "mitochondrial ribosomal small subunit" EXACT [] +xref: GO:0005763 +relationship: part_of FPLX:000288 ! Mitochondrial_Ribosome +relationship: has_part HGNC:14495 ! MRPS2 +relationship: has_part HGNC:14498 ! MRPS5 +relationship: has_part HGNC:14051 ! MRPS6 +relationship: has_part HGNC:14499 ! MRPS7 +relationship: has_part HGNC:14501 ! MRPS9 +relationship: has_part HGNC:14502 ! MRPS10 +relationship: has_part HGNC:14050 ! MRPS11 +relationship: has_part HGNC:10380 ! MRPS12 +relationship: has_part HGNC:14049 ! MRPS14 +relationship: has_part HGNC:14504 ! MRPS15 +relationship: has_part HGNC:14048 ! MRPS16 +relationship: has_part HGNC:14047 ! MRPS17 +relationship: has_part HGNC:14515 ! MRPS18A +relationship: has_part HGNC:14516 ! MRPS18B +relationship: has_part HGNC:16633 ! MRPS18C +relationship: has_part HGNC:14046 ! MRPS21 +relationship: has_part HGNC:14508 ! MRPS22 +relationship: has_part HGNC:14509 ! MRPS23 +relationship: has_part HGNC:14510 ! MRPS24 +relationship: has_part HGNC:14511 ! MRPS25 +relationship: has_part HGNC:14045 ! MRPS26 +relationship: has_part HGNC:14512 ! MRPS27 +relationship: has_part HGNC:14513 ! MRPS28 +relationship: has_part HGNC:2673 ! DAP3 +relationship: has_part HGNC:8769 ! MRPS30 +relationship: has_part HGNC:16632 ! MRPS31 +relationship: has_part HGNC:16634 ! MRPS33 +relationship: has_part HGNC:16618 ! MRPS34 +relationship: has_part HGNC:16635 ! MRPS35 +relationship: has_part HGNC:16631 ! MRPS36 + +[Term] +id: FPLX:000290 +name: MRPL +synonym: "large mitoribosomal subunit" EXACT [] +synonym: "Large Mitoribosomal Subunit" EXACT [] +synonym: "large subunit of the mammalian mitochondrial ribosome" EXACT [] +synonym: "mitochondrial ribosomal large subunit" EXACT [] +xref: GO:0005762 +relationship: part_of FPLX:000288 ! Mitochondrial_Ribosome +relationship: has_part HGNC:14275 ! MRPL1 +relationship: has_part HGNC:14056 ! MRPL2 +relationship: has_part HGNC:10379 ! MRPL3 +relationship: has_part HGNC:14276 ! MRPL4 +relationship: has_part HGNC:14277 ! MRPL9 +relationship: has_part HGNC:14055 ! MRPL10 +relationship: has_part HGNC:14042 ! MRPL11 +relationship: has_part HGNC:10378 ! MRPL12 +relationship: has_part HGNC:14278 ! MRPL13 +relationship: has_part HGNC:14279 ! MRPL14 +relationship: has_part HGNC:14054 ! MRPL15 +relationship: has_part HGNC:14476 ! MRPL16 +relationship: has_part HGNC:14053 ! MRPL17 +relationship: has_part HGNC:14477 ! MRPL18 +relationship: has_part HGNC:14052 ! MRPL19 +relationship: has_part HGNC:14478 ! MRPL20 +relationship: has_part HGNC:14479 ! MRPL21 +relationship: has_part HGNC:14480 ! MRPL22 +relationship: has_part HGNC:10322 ! MRPL23 +relationship: has_part HGNC:14037 ! MRPL24 +relationship: has_part HGNC:14483 ! MRPL27 +relationship: has_part HGNC:14484 ! MRPL28 +relationship: has_part HGNC:14036 ! MRPL30 +relationship: has_part HGNC:14035 ! MRPL32 +relationship: has_part HGNC:14487 ! MRPL33 +relationship: has_part HGNC:14488 ! MRPL34 +relationship: has_part HGNC:14489 ! MRPL35 +relationship: has_part HGNC:14490 ! MRPL36 +relationship: has_part HGNC:14034 ! MRPL37 +relationship: has_part HGNC:14033 ! MRPL38 +relationship: has_part HGNC:14027 ! MRPL39 +relationship: has_part HGNC:14491 ! MRPL40 +relationship: has_part HGNC:14492 ! MRPL41 +relationship: has_part HGNC:14493 ! MRPL42 +relationship: has_part HGNC:14517 ! MRPL43 +relationship: has_part HGNC:16650 ! MRPL44 +relationship: has_part HGNC:16651 ! MRPL45 +relationship: has_part HGNC:1192 ! MRPL46 +relationship: has_part HGNC:16652 ! MRPL47 +relationship: has_part HGNC:16653 ! MRPL48 +relationship: has_part HGNC:1176 ! MRPL49 +relationship: has_part HGNC:16654 ! MRPL50 +relationship: has_part HGNC:14044 ! MRPL51 +relationship: has_part HGNC:16655 ! MRPL52 +relationship: has_part HGNC:16684 ! MRPL53 +relationship: has_part HGNC:16685 ! MRPL54 +relationship: has_part HGNC:16686 ! MRPL55 +relationship: has_part HGNC:14514 ! MRPL57 + +[Term] +id: FPLX:000291 +name: MMP +synonym: "MMP" EXACT [] +synonym: "MMPs" EXACT [] +xref: BEL:"MMP Family" +xref: NCIT:C18164 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:7155 ! MMP1 +relationship: inverse_is_a HGNC:7166 ! MMP2 +relationship: inverse_is_a HGNC:7173 ! MMP3 +relationship: inverse_is_a HGNC:7174 ! MMP7 +relationship: inverse_is_a HGNC:7175 ! MMP8 +relationship: inverse_is_a HGNC:7176 ! MMP9 +relationship: inverse_is_a HGNC:7156 ! MMP10 +relationship: inverse_is_a HGNC:7157 ! MMP11 +relationship: inverse_is_a HGNC:7158 ! MMP12 +relationship: inverse_is_a HGNC:7159 ! MMP13 +relationship: inverse_is_a HGNC:7160 ! MMP14 +relationship: inverse_is_a HGNC:7161 ! MMP15 +relationship: inverse_is_a HGNC:7162 ! MMP16 +relationship: inverse_is_a HGNC:7163 ! MMP17 +relationship: inverse_is_a HGNC:7165 ! MMP19 +relationship: inverse_is_a HGNC:7167 ! MMP20 +relationship: inverse_is_a HGNC:14357 ! MMP21 +relationship: inverse_is_a HGNC:7171 ! MMP23B +relationship: inverse_is_a HGNC:7172 ! MMP24 +relationship: inverse_is_a HGNC:14246 ! MMP25 +relationship: inverse_is_a HGNC:14249 ! MMP26 +relationship: inverse_is_a HGNC:14250 ! MMP27 +relationship: inverse_is_a HGNC:14366 ! MMP28 + +[Term] +id: FPLX:000292 +name: Metallothionein +synonym: "Metallothionein" EXACT [] +synonym: "metallothionein" EXACT [] +synonym: "MT" EXACT [] +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:7393 ! MT1A +relationship: inverse_is_a HGNC:7394 ! MT1B +relationship: inverse_is_a HGNC:7395 ! MT1CP +relationship: inverse_is_a HGNC:7396 ! MT1DP +relationship: inverse_is_a HGNC:7397 ! MT1E +relationship: inverse_is_a HGNC:7398 ! MT1F +relationship: inverse_is_a HGNC:7399 ! MT1G +relationship: inverse_is_a HGNC:7400 ! MT1H +relationship: inverse_is_a HGNC:31864 ! MT1HL1 +relationship: inverse_is_a HGNC:7401 ! MT1IP +relationship: inverse_is_a HGNC:7402 ! MT1JP +relationship: inverse_is_a HGNC:7404 ! MT1L +relationship: inverse_is_a HGNC:14296 ! MT1M +relationship: inverse_is_a HGNC:23681 ! MT1P1 +relationship: inverse_is_a HGNC:16120 ! MT1P3 +relationship: inverse_is_a HGNC:7405 ! MT1X +relationship: inverse_is_a HGNC:7406 ! MT2A +relationship: inverse_is_a HGNC:7408 ! MT3 +relationship: inverse_is_a HGNC:18705 ! MT4 + +[Term] +id: FPLX:000293 +name: mTORC1 +synonym: "mTORC1" EXACT [] +synonym: "TORC1" EXACT [] +xref: GO:0031931 +xref: MEDSCAN:urn:agi-complex:prophash-f472fef3f59301aee0b776702a30f03e +xref: NCIT:C96314 +is_a: FPLX:000000 ! famplex +relationship: has_part HGNC:3942 ! MTOR +relationship: has_part HGNC:30287 ! RPTOR + +[Term] +id: FPLX:000294 +name: mTORC2 +synonym: "mTORC2" EXACT [] +synonym: "TORC2" EXACT [] +xref: BEL:"TORC2 Complex" +xref: MEDSCAN:urn:agi-complex:prophash-0d528c29d63997f87f62e4fbd9f0b168 +xref: NCIT:C96315 +is_a: FPLX:000000 ! famplex +relationship: has_part HGNC:18752 ! MAPKAP1 +relationship: has_part HGNC:3942 ! MTOR +relationship: has_part HGNC:28611 ! RICTOR +relationship: has_part HGNC:24825 ! MLST8 + +[Term] +id: FPLX:000295 +name: MYH +synonym: "myosin heavy chain genes" EXACT [] +synonym: "myosin heavy chain isoforms" EXACT [] +synonym: "myosin heavy chain protein" EXACT [] +synonym: "Myosin heavy chain" EXACT [] +synonym: "myosin heavy chain" EXACT [] +synonym: "Myosin heavy chains" EXACT [] +synonym: "myosin heavy chains" EXACT [] +xref: BEL:"MYH Family" +xref: MEDSCAN:urn:agi-protfc:myosin%20heavy%20chain +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:7567 ! MYH1 +relationship: inverse_is_a HGNC:7568 ! MYH10 +relationship: inverse_is_a HGNC:7569 ! MYH11 +relationship: inverse_is_a HGNC:7571 ! MYH13 +relationship: inverse_is_a HGNC:23212 ! MYH14 +relationship: inverse_is_a HGNC:31073 ! MYH15 +relationship: inverse_is_a HGNC:7572 ! MYH2 +relationship: inverse_is_a HGNC:7573 ! MYH3 +relationship: inverse_is_a HGNC:7574 ! MYH4 +relationship: inverse_is_a HGNC:7576 ! MYH6 +relationship: inverse_is_a HGNC:7577 ! MYH7 +relationship: inverse_is_a HGNC:15906 ! MYH7B +relationship: inverse_is_a HGNC:7578 ! MYH8 +relationship: inverse_is_a HGNC:7579 ! MYH9 +relationship: inverse_is_a HGNC:7602 ! MYO5A + +[Term] +id: FPLX:000296 +name: MYL +synonym: "MLC" EXACT [] +synonym: "myosin light chain protein" EXACT [] +synonym: "myosin light chain" EXACT [] +synonym: "myosin light chains" EXACT [] +xref: BEL:"MYL Family" +xref: MEDSCAN:urn:agi-protfc:myosin%20light%20chain +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a FPLX:000297 ! MYL_alkali +relationship: inverse_is_a FPLX:000298 ! MYL_regulatory +relationship: inverse_is_a FPLX:000299 ! MYL_slow + +[Term] +id: FPLX:000297 +name: MYL-alkali +synonym: "alkali myosin light chains" EXACT [] +synonym: "AMLC" EXACT [] +synonym: "myosin alkali light chain proteins" EXACT [] +synonym: "myosin alkali light chain" EXACT [] +xref: BEL:"MYL Alkali Family" +is_a: FPLX:000296 ! MYL +relationship: inverse_is_a HGNC:7582 ! MYL1 +relationship: inverse_is_a HGNC:7584 ! MYL3 +relationship: inverse_is_a HGNC:7585 ! MYL4 +relationship: inverse_is_a HGNC:7587 ! MYL6 +relationship: inverse_is_a HGNC:29823 ! MYL6B + +[Term] +id: FPLX:000298 +name: MYL-regulatory +synonym: "regulatory myosin light chain" EXACT [] +xref: BEL:"MYL Regulatory Family" +is_a: FPLX:000296 ! MYL +relationship: inverse_is_a HGNC:29825 ! MYL10 +relationship: inverse_is_a HGNC:16701 ! MYL12A +relationship: inverse_is_a HGNC:29827 ! MYL12B +relationship: inverse_is_a HGNC:7583 ! MYL2 +relationship: inverse_is_a HGNC:7586 ! MYL5 +relationship: inverse_is_a HGNC:21719 ! MYL7 +relationship: inverse_is_a HGNC:15754 ! MYL9 +relationship: inverse_is_a HGNC:29824 ! MYLPF + +[Term] +id: FPLX:000299 +name: MYL-slow +synonym: "slow myosin" EXACT [] +xref: BEL:"MYL Slow Family" +is_a: FPLX:000296 ! MYL +relationship: inverse_is_a HGNC:7583 ! MYL2 +relationship: inverse_is_a HGNC:7584 ! MYL3 +relationship: inverse_is_a HGNC:29823 ! MYL6B + +[Term] +id: FPLX:000300 +name: MYST +synonym: "MYST family" EXACT [] +synonym: "MYST histone acetylase" EXACT [] +synonym: "MYST proteins" EXACT [] +xref: BEL:"MYST Family" +xref: IP:IPR002717 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:17933 ! KAT8 +relationship: inverse_is_a HGNC:17016 ! KAT7 +relationship: inverse_is_a HGNC:13013 ! KAT6A +relationship: inverse_is_a HGNC:17582 ! KAT6B +relationship: inverse_is_a HGNC:5275 ! KAT5 + +[Term] +id: FPLX:000301 +name: NADH-dehydrogenase +synonym: "NADH dehydrogenase (ubiquinone)" EXACT [] +synonym: "NADH dehydrogenase" EXACT [] +xref: BEL:"NADH Dehydrogenase Complex" +xref: ECCODE:1.6.5.3 +xref: XFAM:PF00146 +is_a: FPLX:000000 ! famplex +relationship: has_part HGNC:7455 ! MT-ND1 +relationship: has_part HGNC:7456 ! MT-ND2 +relationship: has_part HGNC:7458 ! MT-ND3 +relationship: has_part HGNC:7459 ! MT-ND4 +relationship: has_part HGNC:7460 ! MT-ND4L +relationship: has_part HGNC:7461 ! MT-ND5 +relationship: has_part HGNC:7462 ! MT-ND6 + +[Term] +id: FPLX:000302 +name: NADPH-oxidase +synonym: "NAD(P)H oxidase" EXACT [] +synonym: "NAD(P)H-oxidase" EXACT [] +synonym: "NADPH oxidase" EXACT [] +xref: BEL:"NADPH Oxidase Complex" +xref: MEDSCAN:urn:agi-aopfc:0000479 +is_a: FPLX:000000 ! famplex +relationship: has_part HGNC:2577 ! CYBA +relationship: has_part HGNC:2578 ! CYBB +relationship: has_part HGNC:3062 ! DUOX1 +relationship: has_part HGNC:13273 ! DUOX2 +relationship: has_part HGNC:7660 ! NCF1 +relationship: has_part HGNC:7661 ! NCF2 +relationship: has_part HGNC:7662 ! NCF4 +relationship: has_part HGNC:7889 ! NOX1 +relationship: has_part HGNC:7890 ! NOX3 +relationship: has_part HGNC:7891 ! NOX4 +relationship: has_part HGNC:14874 ! NOX5 +relationship: has_part HGNC:9801 ! RAC1 + +[Term] +id: FPLX:000303 +name: Na-K-ATPase +synonym: "Na(+),K(+)-ATPase" EXACT [] +synonym: "Na,K-ATPase" EXACT [] +synonym: "Na+/K+-exchanging ATPase" EXACT [] +synonym: "Na+/K+ATPase" EXACT [] +synonym: "Na/K-ATPase" EXACT [] +xref: BEL:"Na/K Exchanging ATPase Complex" +xref: ECCODE:3.6.3.9 +is_a: FPLX:000000 ! famplex +relationship: has_part FPLX:000057 ! ATP1A +relationship: has_part FPLX:000058 ! ATP1B + +[Term] +id: FPLX:000304 +name: Natriuretic-peptide +synonym: "Natriuretic Peptide" EXACT [] +synonym: "Natriuretic peptide" EXACT [] +synonym: "natriuretic peptide" EXACT [] +synonym: "Natriuretic Peptides" EXACT [] +synonym: "Natriuretic peptides" EXACT [] +synonym: "natriuretic peptides" EXACT [] +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:7939 ! NPPA +relationship: inverse_is_a HGNC:7940 ! NPPB +relationship: inverse_is_a HGNC:7941 ! NPPC + +[Term] +id: FPLX:000305 +name: NCOA +synonym: "p160/SRC" EXACT [] +xref: BEL:"p160/SRC Family" +xref: IP:IPR010011 +xref: IP:IPR014920 +xref: IP:IPR014935 +xref: IP:IPR017426 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:7668 ! NCOA1 +relationship: inverse_is_a HGNC:7669 ! NCOA2 +relationship: inverse_is_a HGNC:7670 ! NCOA3 + +[Term] +id: FPLX:000306 +name: NCOR +synonym: "Nuclear Receptor Co-Repressor" EXACT [] +synonym: "nuclear receptor co-repressor" EXACT [] +synonym: "Nuclear receptor corepressor" EXACT [] +synonym: "nuclear receptor corepressor" EXACT [] +xref: BEL:"NCOR Family" +xref: RE:R-HSA-349716 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:7672 ! NCOR1 +relationship: inverse_is_a HGNC:7673 ! NCOR2 + +[Term] +id: FPLX:000307 +name: NDRG +synonym: "N-myc downstream regulated gene family" EXACT [] +synonym: "NDR family" EXACT [] +synonym: "NDR-family" EXACT [] +xref: BEL:"NDRG Family" +xref: IP:IPR004142 +xref: XFAM:PF03096 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:7679 ! NDRG1 +relationship: inverse_is_a HGNC:14460 ! NDRG2 +relationship: inverse_is_a HGNC:14462 ! NDRG3 +relationship: inverse_is_a HGNC:14466 ! NDRG4 + +[Term] +id: FPLX:000308 +name: Neurexins +synonym: "Neurexins" EXACT [] +synonym: "NRXN" EXACT [] +xref: GFAM:1582 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:8008 ! NRXN1 +relationship: inverse_is_a HGNC:8009 ! NRXN2 +relationship: inverse_is_a HGNC:8010 ! NRXN3 + +[Term] +id: FPLX:000309 +name: NFAT +synonym: "NFAT" EXACT [] +xref: BEL:"NFAT Family" +xref: IP:IPR008366 +xref: NCIT:C17903 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:7775 ! NFATC1 +relationship: inverse_is_a HGNC:7776 ! NFATC2 +relationship: inverse_is_a HGNC:7777 ! NFATC3 +relationship: inverse_is_a HGNC:7778 ! NFATC4 +relationship: inverse_is_a HGNC:7774 ! NFAT5 + +[Term] +id: FPLX:000310 +name: NFE +synonym: "NF-E2" EXACT [] +synonym: "NF-E2-related factor" EXACT [] +synonym: "Nuclear factor erythroid 2-related factor" EXACT [] +xref: MEDSCAN:urn:agi-aopfc:0000150 +xref: MEDSCAN:urn:agi-complex:NF-E2 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:7781 ! NFE2L1 +relationship: inverse_is_a HGNC:7782 ! NFE2L2 +relationship: inverse_is_a HGNC:7783 ! NFE2L3 + +[Term] +id: FPLX:000311 +name: NFkappaB +synonym: "NF-kappaB complexes" EXACT [] +synonym: "NF-kappaB dimers" EXACT [] +synonym: "NF-kappaB Factors" EXACT [] +synonym: "NF-kappaB factors" EXACT [] +synonym: "NF-kappaB genes" EXACT [] +synonym: "NF-kappaB subunits" EXACT [] +synonym: "NF-kappaB TFs" EXACT [] +synonym: "NF-kappaB" EXACT [] +synonym: "NF-kappabeta" EXACT [] +synonym: "NF-kappaBs" EXACT [] +synonym: "NF-kB" EXACT [] +synonym: "NF-κB complexes" EXACT [] +synonym: "NF-κB dimers" EXACT [] +synonym: "NF-κB Factors" EXACT [] +synonym: "NF-κB factors" EXACT [] +synonym: "NF-κB genes" EXACT [] +synonym: "NF-κB subunits" EXACT [] +synonym: "NF-κB TFs" EXACT [] +synonym: "NF-κB" EXACT [] +synonym: "NF-κBs" EXACT [] +synonym: "NF-κβ" EXACT [] +synonym: "NFkappaB complexes" EXACT [] +synonym: "NFkappaB" EXACT [] +synonym: "NFκB complexes" EXACT [] +synonym: "NFκB" EXACT [] +xref: BEL:"Nfkb Complex" +xref: IP:IPR000451 +xref: IP:IPR030492 +xref: IP:IPR033926 +xref: MEDSCAN:urn:agi-aopfc:0000156 +xref: MEDSCAN:urn:agi-complex:prophash-8cfce9bfac3857e6f068d517deadfeaa +xref: NCIT:C17380 +xref: SIGNOR:SIGNOR-PF12 +is_a: FPLX:000000 ! famplex +relationship: has_part FPLX:000312 ! NFkappaB_1 +relationship: has_part FPLX:000313 ! NFkappaB_2 + +[Term] +id: FPLX:000312 +name: NFkappaB-1 +synonym: "Class 1 NF-kappaBs" EXACT [] +synonym: "class 1 NF-kappaBs" EXACT [] +synonym: "Class 1 NF-κBs" EXACT [] +synonym: "class 1 NF-κBs" EXACT [] +synonym: "Class I NF-kappaBs" EXACT [] +synonym: "class I NF-kappaBs" EXACT [] +synonym: "Class I NF-κBs" EXACT [] +synonym: "class I NF-κBs" EXACT [] +synonym: "NF-kappaB Class 1" EXACT [] +synonym: "NF-kappaB class 1" EXACT [] +synonym: "NF-kappaB Class I" EXACT [] +synonym: "NF-kappaB class I" EXACT [] +synonym: "NF-κB Class 1" EXACT [] +synonym: "NF-κB class 1" EXACT [] +synonym: "NF-κB Class I" EXACT [] +synonym: "NF-κB class I" EXACT [] +xref: RE:R-HSA-177656 +xref: RE:R-HSA-177662 +relationship: part_of FPLX:000311 ! NFkappaB +relationship: inverse_is_a HGNC:7794 ! NFKB1 +relationship: inverse_is_a HGNC:7795 ! NFKB2 + +[Term] +id: FPLX:000313 +name: NFkappaB-2 +synonym: "Class 2 NF-kappaBs" EXACT [] +synonym: "class 2 NF-kappaBs" EXACT [] +synonym: "Class 2 NF-κBs" EXACT [] +synonym: "class 2 NF-κBs" EXACT [] +synonym: "Class II NF-kappaBs" EXACT [] +synonym: "class II NF-kappaBs" EXACT [] +synonym: "Class II NF-κBs" EXACT [] +synonym: "class II NF-κBs" EXACT [] +synonym: "NF-kappaB Class 2" EXACT [] +synonym: "NF-kappaB class 2" EXACT [] +synonym: "NF-kappaB Class II" EXACT [] +synonym: "NF-kappaB class II" EXACT [] +synonym: "NF-κB Class 2" EXACT [] +synonym: "NF-κB class 2" EXACT [] +synonym: "NF-κB Class II" EXACT [] +synonym: "NF-κB class II" EXACT [] +relationship: part_of FPLX:000311 ! NFkappaB +relationship: inverse_is_a HGNC:9955 ! RELA +relationship: inverse_is_a HGNC:9956 ! RELB +relationship: inverse_is_a HGNC:9954 ! REL + +[Term] +id: FPLX:000314 +name: NFY +synonym: "NF-Y" EXACT [] +synonym: "NFY" EXACT [] +synonym: "nuclear factor Y" EXACT [] +synonym: "nuclear factor-Y" EXACT [] +xref: BEL:"Nfy Complex" +xref: RE:R-HSA-2426131 +xref: RE:R-HSA-381204 +is_a: FPLX:000000 ! famplex +relationship: has_part HGNC:7804 ! NFYA +relationship: has_part HGNC:7805 ! NFYB +relationship: has_part HGNC:7806 ! NFYC + +[Term] +id: FPLX:000315 +name: NKD +synonym: "naked cuticle" EXACT [] +xref: BEL:"NKD Family" +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:17045 ! NKD1 +relationship: inverse_is_a HGNC:17046 ! NKD2 + +[Term] +id: FPLX:000316 +name: NOS +synonym: "NOS" EXACT [] +xref: BEL:"NOS Family" +xref: IP:IPR004030 +xref: IP:IPR012144 +xref: MEDSCAN:urn:agi-aopfc:0000494 +xref: NEXTPROT-FAMILY:02504 +xref: RE:R-HSA-419294 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:7872 ! NOS1 +relationship: inverse_is_a HGNC:7873 ! NOS2 +relationship: inverse_is_a HGNC:7876 ! NOS3 + +[Term] +id: FPLX:000317 +name: Notch +synonym: "Notch" EXACT [] +xref: BEL:"NOTCH Family" +xref: IP:IPR008297 +xref: IP:IPR010660 +xref: IP:IPR011656 +xref: MEDSCAN:urn:agi-aopfc:0000279 +xref: NEXTPROT-FAMILY:02506 +xref: XFAM:PF00066 +xref: RE:R-HSA-1911440 +xref: RE:R-HSA-1911472 +xref: RE:R-HSA-1911474 +xref: RE:R-HSA-1911547 +xref: RE:R-HSA-1911550 +xref: RE:R-HSA-212420 +xref: SIGNOR:SIGNOR-PF30 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:7881 ! NOTCH1 +relationship: inverse_is_a HGNC:7882 ! NOTCH2 +relationship: inverse_is_a HGNC:7883 ! NOTCH3 +relationship: inverse_is_a HGNC:7884 ! NOTCH4 + +[Term] +id: FPLX:000318 +name: NRG +synonym: "neuregulin family" EXACT [] +synonym: "Neuregulin" EXACT [] +synonym: "neuregulin" EXACT [] +synonym: "Neuregulins" EXACT [] +synonym: "neuregulins" EXACT [] +synonym: "NRGs" EXACT [] +xref: MEDSCAN:urn:agi-protfc:neuregulin%20family +xref: XFAM:PF02158 +xref: RE:R-HSA-1227957 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a FPLX:000319 ! NRG_1_2 +relationship: inverse_is_a FPLX:000320 ! NRG_3_4 + +[Term] +id: FPLX:000319 +name: NRG-1-2 +synonym: "NRG1-NRG2" EXACT [] +synonym: "NRG1/2" EXACT [] +xref: BEL:"NRG1/2 Family" +xref: RE:R-HSA-1227956 +xref: RE:R-HSA-1247495 +xref: RE:R-HSA-1248743 +is_a: FPLX:000318 ! NRG +relationship: inverse_is_a HGNC:7997 ! NRG1 +relationship: inverse_is_a HGNC:7998 ! NRG2 + +[Term] +id: FPLX:000320 +name: NRG-3-4 +synonym: "NRG3-NRG4" EXACT [] +synonym: "NRG3/4" EXACT [] +xref: BEL:"NRG3/4 Family" +is_a: FPLX:000318 ! NRG +relationship: inverse_is_a HGNC:7999 ! NRG3 +relationship: inverse_is_a HGNC:29862 ! NRG4 + +[Term] +id: FPLX:000321 +name: NTRK +synonym: "NTRK" EXACT [] +synonym: "NTRKs" EXACT [] +synonym: "Trk receptor" EXACT [] +synonym: "trk receptor" EXACT [] +synonym: "Trk receptors" EXACT [] +synonym: "trk receptors" EXACT [] +xref: BEL:"NTRK Family" +xref: IP:IPR020777 +xref: IP:IPR031635 +xref: MEDSCAN:urn:agi-aopfc:0000278 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:8031 ! NTRK1 +relationship: inverse_is_a HGNC:8032 ! NTRK2 +relationship: inverse_is_a HGNC:8033 ! NTRK3 + +[Term] +id: FPLX:000322 +name: OGT-family +is_a: FPLX:000198 ! Glycosyltransferase +relationship: inverse_is_a HGNC:28526 ! EOGT +relationship: inverse_is_a HGNC:8127 ! OGT +relationship: inverse_is_a HGNC:19139 ! POMGNT1 +relationship: inverse_is_a HGNC:25902 ! POMGNT2 + +[Term] +id: FPLX:000323 +name: p14-3-3 +synonym: "14-3-3 proteins" EXACT [] +synonym: "14-3-3" EXACT [] +xref: BEL:"14-3-3 Family" +xref: IP:IPR000308 +xref: IP:IPR023409 +xref: IP:IPR023410 +xref: MEDSCAN:urn:agi-protfc:14-3-3 +xref: XFAM:PF00244 +xref: RE:R-HSA-1445138 +xref: RE:R-HSA-2457842 +xref: SIGNOR:SIGNOR-PF7 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:10773 ! SFN +relationship: inverse_is_a HGNC:12849 ! YWHAB +relationship: inverse_is_a HGNC:12851 ! YWHAE +relationship: inverse_is_a HGNC:12852 ! YWHAG +relationship: inverse_is_a HGNC:12853 ! YWHAH +relationship: inverse_is_a HGNC:12854 ! YWHAQ +relationship: inverse_is_a HGNC:12855 ! YWHAZ + +[Term] +id: FPLX:000324 +name: P2RX +synonym: "P2X purinoreceptor" EXACT [] +synonym: "P2X purinoreceptors" EXACT [] +synonym: "P2X receptor" EXACT [] +synonym: "P2X receptors" EXACT [] +synonym: "P2X" EXACT [] +xref: BEL:"P2RX Family" +xref: GO:0004931 +xref: IP:IPR001429 +xref: IP:IPR027309 +xref: NEXTPROT-FAMILY:02630 +xref: XFAM:PF00864 +xref: RE:R-HSA-139848 +xref: RE:R-HSA-8861873 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:8533 ! P2RX1 +relationship: inverse_is_a HGNC:15459 ! P2RX2 +relationship: inverse_is_a HGNC:8534 ! P2RX3 +relationship: inverse_is_a HGNC:8535 ! P2RX4 +relationship: inverse_is_a HGNC:8536 ! P2RX5 +relationship: inverse_is_a HGNC:8538 ! P2RX6 +relationship: inverse_is_a HGNC:8537 ! P2RX7 + +[Term] +id: FPLX:000325 +name: P2RY +synonym: "P2Y receptor" EXACT [] +xref: BEL:"P2RY Family" +xref: MEDSCAN:urn:agi-protfc:p2y%20receptor +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:8539 ! P2RY1 +relationship: inverse_is_a HGNC:8541 ! P2RY2 +relationship: inverse_is_a HGNC:8542 ! P2RY4 +relationship: inverse_is_a HGNC:8543 ! P2RY6 +relationship: inverse_is_a HGNC:15524 ! P2RY8 +relationship: inverse_is_a HGNC:19906 ! P2RY10 +relationship: inverse_is_a HGNC:8540 ! P2RY11 +relationship: inverse_is_a HGNC:18124 ! P2RY12 +relationship: inverse_is_a HGNC:4537 ! P2RY13 +relationship: inverse_is_a HGNC:16442 ! P2RY14 +relationship: inverse_is_a HGNC:4478 ! LPAR4 +relationship: inverse_is_a HGNC:15520 ! LPAR6 + +[Term] +id: FPLX:000326 +name: p38 +synonym: "MAPK p38" EXACT [] +synonym: "P38 MAPK" EXACT [] +synonym: "p38 MAPK" EXACT [] +synonym: "p38 MAPKs" EXACT [] +synonym: "p38" EXACT [] +synonym: "p38-MAPK" EXACT [] +synonym: "p38MAPK" EXACT [] +xref: BEL:"MAPK p38 Family" +xref: IP:IPR008352 +xref: MEDSCAN:urn:agi-aopfc:0000477 +xref: RE:R-HSA-1250100 +xref: RE:R-HSA-1250102 +xref: RE:R-HSA-171016 +xref: RE:R-HSA-189828 +xref: SIGNOR:SIGNOR-PF16 +is_a: FPLX:000283 ! MAPK +relationship: inverse_is_a HGNC:6873 ! MAPK11 +relationship: inverse_is_a HGNC:6874 ! MAPK12 +relationship: inverse_is_a HGNC:6875 ! MAPK13 +relationship: inverse_is_a HGNC:6876 ! MAPK14 + +[Term] +id: FPLX:000327 +name: p53-family +synonym: "P53 family" EXACT [] +synonym: "p53 Family" EXACT [] +synonym: "p53 family" EXACT [] +synonym: "p53/p63/p73 family" EXACT [] +xref: IP:IPR002117 +xref: IP:IPR010991 +xref: IP:IPR011615 +xref: NEXTPROT-FAMILY:02632 +xref: XFAM:PF00870 +xref: RE:R-HSA-6798076 +xref: RE:R-HSA-6798078 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:11998 ! TP53 +relationship: inverse_is_a HGNC:15979 ! TP63 +relationship: inverse_is_a HGNC:12003 ! TP73 + +[Term] +id: FPLX:000328 +name: P70S6K +synonym: "p70 S6 kinase" EXACT [] +synonym: "P70RSK" EXACT [] +synonym: "p70RSK" EXACT [] +synonym: "P70S6K" EXACT [] +synonym: "S6K" EXACT [] +xref: BEL:"RPS6KB Family" +xref: MEDSCAN:urn:agi-protfc:p70rsk +is_a: FPLX:000422 ! RSK +relationship: inverse_is_a HGNC:10436 ! RPS6KB1 +relationship: inverse_is_a HGNC:10437 ! RPS6KB2 + +[Term] +id: FPLX:000329 +name: P90RSK +synonym: "p90RSK" EXACT [] +synonym: "RPS6KA" EXACT [] +xref: BEL:"RPS6KA Family" +xref: IP:IPR016239 +xref: MEDSCAN:urn:agi-protfc:p90rsk +xref: RE:R-HSA-446849 +xref: SIGNOR:SIGNOR-PF26 +is_a: FPLX:000422 ! RSK +relationship: inverse_is_a HGNC:10430 ! RPS6KA1 +relationship: inverse_is_a HGNC:10431 ! RPS6KA2 +relationship: inverse_is_a HGNC:10432 ! RPS6KA3 +relationship: inverse_is_a HGNC:10433 ! RPS6KA4 +relationship: inverse_is_a HGNC:10434 ! RPS6KA5 +relationship: inverse_is_a HGNC:10435 ! RPS6KA6 + +[Term] +id: FPLX:000330 +name: PAK +synonym: "PAK" EXACT [] +synonym: "Pak" EXACT [] +xref: BEL:"PAK Family" +xref: IP:IPR033923 +xref: MEDSCAN:urn:agi-aopfc:0000468 +xref: RE:R-HSA-428475 +xref: SIGNOR:SIGNOR-PF13 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:8590 ! PAK1 +relationship: inverse_is_a HGNC:8591 ! PAK2 +relationship: inverse_is_a HGNC:8592 ! PAK3 +relationship: inverse_is_a HGNC:16059 ! PAK4 +relationship: inverse_is_a HGNC:15916 ! PAK5 +relationship: inverse_is_a HGNC:16061 ! PAK6 + +[Term] +id: FPLX:000331 +name: PARP +synonym: "PARP genes" EXACT [] +synonym: "PARPs" EXACT [] +synonym: "Poly(ADP-ribose) polymerase" EXACT [] +synonym: "Poly(ADP-ribose) polymerases" EXACT [] +xref: XFAM:PF00644 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:270 ! PARP1 +relationship: inverse_is_a HGNC:272 ! PARP2 +relationship: inverse_is_a HGNC:273 ! PARP3 +relationship: inverse_is_a HGNC:271 ! PARP4 +relationship: inverse_is_a HGNC:26921 ! PARP6 +relationship: inverse_is_a HGNC:26124 ! PARP8 +relationship: inverse_is_a HGNC:24118 ! PARP9 +relationship: inverse_is_a HGNC:25895 ! PARP10 +relationship: inverse_is_a HGNC:1186 ! PARP11 +relationship: inverse_is_a HGNC:21919 ! PARP12 +relationship: inverse_is_a HGNC:29232 ! PARP14 +relationship: inverse_is_a HGNC:26876 ! PARP15 +relationship: inverse_is_a HGNC:26040 ! PARP16 +relationship: inverse_is_a HGNC:11941 ! TNKS +relationship: inverse_is_a HGNC:15677 ! TNKS2 +relationship: inverse_is_a HGNC:23696 ! TIPARP + +[Term] +id: FPLX:000332 +name: PARV +synonym: "Parvin" EXACT [] +synonym: "parvin" EXACT [] +synonym: "Parvins" EXACT [] +synonym: "parvins" EXACT [] +xref: BEL:"PARV Family" +xref: IP:IPR028433 +xref: NEXTPROT-FAMILY:02660 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:14652 ! PARVA +relationship: inverse_is_a HGNC:14653 ! PARVB +relationship: inverse_is_a HGNC:14654 ! PARVG + +[Term] +id: FPLX:000333 +name: Patched +synonym: "PATCHED" EXACT [] +synonym: "Patched" EXACT [] +xref: IP:IPR004766 +xref: MEDSCAN:urn:agi-aopfc:0000281 +xref: XFAM:PF02460 +xref: RE:R-HSA-445134 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:9585 ! PTCH1 +relationship: inverse_is_a HGNC:9586 ! PTCH2 + +[Term] +id: FPLX:000334 +name: PBX +synonym: "PBX" EXACT [] +synonym: "Pbx" EXACT [] +synonym: "pbx" EXACT [] +synonym: "PBXs" EXACT [] +xref: BEL:"PBX Family" +xref: IP:IPR005542 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:8632 ! PBX1 +relationship: inverse_is_a HGNC:8633 ! PBX2 +relationship: inverse_is_a HGNC:8634 ! PBX3 +relationship: inverse_is_a HGNC:13403 ! PBX4 + +[Term] +id: FPLX:000335 +name: PDE +synonym: "PDE" EXACT [] +synonym: "PDEs" EXACT [] +synonym: "Phosphodiesterase" EXACT [] +synonym: "phosphodiesterase" EXACT [] +synonym: "Phosphodiesterases" EXACT [] +synonym: "phosphodiesterases" EXACT [] +xref: BEL:"PDE Family" +xref: ECCODE:3.1.4.- +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:8777 ! PDE2A +relationship: inverse_is_a HGNC:8795 ! PDE9A +relationship: inverse_is_a HGNC:8772 ! PDE10A +relationship: inverse_is_a HGNC:8773 ! PDE11A +relationship: inverse_is_a FPLX:000336 ! PDE1 +relationship: inverse_is_a FPLX:000337 ! PDE3 +relationship: inverse_is_a FPLX:000338 ! PDE4 +relationship: inverse_is_a FPLX:000339 ! PDE6 +relationship: inverse_is_a FPLX:000340 ! PDE7 +relationship: inverse_is_a FPLX:000341 ! PDE8 + +[Term] +id: FPLX:000336 +name: PDE1 +synonym: "PDE1 family" EXACT [] +synonym: "PDE1" EXACT [] +synonym: "Phosphodiesterase 1" EXACT [] +synonym: "phosphodiesterase 1" EXACT [] +synonym: "Phosphodiesterase-1" EXACT [] +synonym: "phosphodiesterase-1" EXACT [] +xref: BEL:"PDE1 Family" +xref: GO:0004117 +xref: IP:IPR013706 +xref: RE:R-HSA-111952 +xref: RE:R-HSA-111953 +is_a: FPLX:000335 ! PDE +relationship: inverse_is_a HGNC:8774 ! PDE1A +relationship: inverse_is_a HGNC:8775 ! PDE1B +relationship: inverse_is_a HGNC:8776 ! PDE1C + +[Term] +id: FPLX:000337 +name: PDE3 +synonym: "PDE 3" EXACT [] +synonym: "PDE3 family" EXACT [] +synonym: "PDE3" EXACT [] +synonym: "Phosphodiesterase 3" EXACT [] +synonym: "phosphodiesterase 3" EXACT [] +synonym: "Phosphodiesterase-3" EXACT [] +synonym: "phosphodiesterase-3" EXACT [] +xref: BEL:"PDE3 Family" +xref: MEDSCAN:urn:agi-protfc:phosphodiesterase%20III +xref: NEXTPROT-FAMILY:00803 +is_a: FPLX:000335 ! PDE +relationship: inverse_is_a HGNC:8778 ! PDE3A +relationship: inverse_is_a HGNC:8779 ! PDE3B + +[Term] +id: FPLX:000338 +name: PDE4 +synonym: "PDE4 family" EXACT [] +synonym: "PDE4 isoforms" EXACT [] +synonym: "PDE4" EXACT [] +synonym: "Phosphodiesterase 4" EXACT [] +synonym: "phosphodiesterase 4" EXACT [] +synonym: "Phosphodiesterase-4" EXACT [] +synonym: "phosphodiesterase-4" EXACT [] +synonym: "type 4 cyclic nucleotide phosphodiesterase" EXACT [] +xref: BEL:"PDE4 Family" +xref: MEDSCAN:urn:agi-protfc:PDE4%20subfamily +xref: NCIT:C107433 +xref: NEXTPROT-FAMILY:00804 +xref: RE:R-HSA-111960 +is_a: FPLX:000335 ! PDE +relationship: inverse_is_a HGNC:8780 ! PDE4A +relationship: inverse_is_a HGNC:8781 ! PDE4B +relationship: inverse_is_a HGNC:8782 ! PDE4C +relationship: inverse_is_a HGNC:8783 ! PDE4D + +[Term] +id: FPLX:000339 +name: PDE6 +synonym: "PDE6 family" EXACT [] +synonym: "PDE6" EXACT [] +synonym: "Phosphodiesterase 6" EXACT [] +synonym: "phosphodiesterase 6" EXACT [] +synonym: "Phosphodiesterase-6" EXACT [] +synonym: "phosphodiesterase-6" EXACT [] +xref: BEL:"PDE6 Family" +xref: MEDSCAN:urn:agi-aopfc:0000704 +is_a: FPLX:000335 ! PDE +relationship: inverse_is_a HGNC:8785 ! PDE6A +relationship: inverse_is_a HGNC:8786 ! PDE6B +relationship: inverse_is_a HGNC:8787 ! PDE6C + +[Term] +id: FPLX:000340 +name: PDE7 +synonym: "PDE7" EXACT [] +synonym: "Phosphodiesterase 7" EXACT [] +synonym: "phosphodiesterase 7" EXACT [] +synonym: "Phosphodiesterase-7" EXACT [] +synonym: "phosphodiesterase-7" EXACT [] +xref: RE:R-HSA-418540 +is_a: FPLX:000335 ! PDE +relationship: inverse_is_a HGNC:8791 ! PDE7A +relationship: inverse_is_a HGNC:8792 ! PDE7B + +[Term] +id: FPLX:000341 +name: PDE8 +synonym: "PDE8" EXACT [] +synonym: "Phosphodiesterase 8" EXACT [] +synonym: "phosphodiesterase 8" EXACT [] +synonym: "Phosphodiesterase-8" EXACT [] +synonym: "phosphodiesterase-8" EXACT [] +xref: RE:R-HSA-418541 +is_a: FPLX:000335 ! PDE +relationship: inverse_is_a HGNC:8793 ! PDE8A +relationship: inverse_is_a HGNC:8794 ! PDE8B + +[Term] +id: FPLX:000342 +name: PDGF +synonym: "PDGF" EXACT [] +xref: BEL:"PDGF Family" +xref: GO:0005161 +xref: NCIT:C20448 +xref: RE:R-HSA-381926 +xref: RE:R-HSA-381936 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:8799 ! PDGFA +relationship: inverse_is_a HGNC:8800 ! PDGFB +relationship: inverse_is_a HGNC:8801 ! PDGFC +relationship: inverse_is_a HGNC:30620 ! PDGFD + +[Term] +id: FPLX:000343 +name: PDGFR +synonym: "PDGFR" EXACT [] +xref: BEL:"PDGFR Family" +xref: NCIT:C17322 +xref: RE:R-HSA-186769 +xref: RE:R-HSA-186770 +xref: RE:R-HSA-186791 +xref: RE:R-HSA-186792 +xref: RE:R-HSA-186821 +xref: RE:R-HSA-8864040 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:8803 ! PDGFRA +relationship: inverse_is_a HGNC:8804 ! PDGFRB + +[Term] +id: FPLX:000344 +name: PDGFR-AA +synonym: "PDGFR-AA" EXACT [] +synonym: "PDGFR-alphaalpha" EXACT [] +synonym: "PDGFR-αα" EXACT [] +synonym: "PDGFRalphaalpha" EXACT [] +synonym: "PDGFRαα" EXACT [] +xref: IP:IPR027290 +xref: RE:R-HSA-186816 +xref: RE:R-HSA-186817 +is_a: FPLX:000000 ! famplex +relationship: has_part HGNC:8803 ! PDGFRA + +[Term] +id: FPLX:000345 +name: PDGFR-AB +synonym: "PDGFR-AB" EXACT [] +synonym: "PDGFR-alphabeta" EXACT [] +synonym: "PDGFR-αβ" EXACT [] +synonym: "PDGFRalphabeta" EXACT [] +synonym: "PDGFRαβ" EXACT [] +xref: RE:R-HSA-186769 +xref: RE:R-HSA-186770 +xref: RE:R-HSA-186791 +xref: RE:R-HSA-186792 +xref: RE:R-HSA-186821 +xref: RE:R-HSA-8864040 +is_a: FPLX:000000 ! famplex +relationship: has_part HGNC:8803 ! PDGFRA +relationship: has_part HGNC:8804 ! PDGFRB + +[Term] +id: FPLX:000346 +name: PDGFR-BB +synonym: "PDGFR-BB" EXACT [] +synonym: "PDGFR-betabeta" EXACT [] +synonym: "PDGFR-ββ" EXACT [] +synonym: "PDGFRbetabeta" EXACT [] +synonym: "PDGFRββ" EXACT [] +xref: IP:IPR027288 +xref: RE:R-HSA-186799 +xref: RE:R-HSA-186805 +xref: RE:R-HSA-8864046 +is_a: FPLX:000000 ! famplex +relationship: has_part HGNC:8804 ! PDGFRB + +[Term] +id: FPLX:000347 +name: PDGF-AA +synonym: "PDGF-AA" EXACT [] +synonym: "PDGF-aa" EXACT [] +synonym: "PDGFAA" EXACT [] +xref: MEDSCAN:urn:agi-complex:platelet%20derived%20growth%20factor%20AA +xref: RE:R-HSA-184203 +is_a: FPLX:000000 ! famplex +relationship: has_part HGNC:8799 ! PDGFA + +[Term] +id: FPLX:000348 +name: PDGF-AB +synonym: "PDGF-AB" EXACT [] +synonym: "PDGF-ab" EXACT [] +synonym: "PDGFAB" EXACT [] +xref: MEDSCAN:urn:agi-complex:platelet%20derived%20growth%20factor%20AB +xref: RE:R-HSA-380759 +is_a: FPLX:000000 ! famplex +relationship: has_part HGNC:8799 ! PDGFA +relationship: has_part HGNC:8800 ! PDGFB + +[Term] +id: FPLX:000349 +name: PDGF-BB +synonym: "PDGF-BB" EXACT [] +synonym: "PDGF-bb" EXACT [] +synonym: "PDGFBB" EXACT [] +xref: IP:IPR015583 +xref: MEDSCAN:urn:agi-complex:platelet%20derived%20growth%20factor%20BB +xref: MESH:C072194 +xref: RE:R-HSA-184196 +xref: RE:R-HSA-184198 +xref: RE:R-HSA-184204 +xref: RE:R-HSA-184206 +xref: RE:R-HSA-2426276 +xref: RE:R-HSA-380748 +xref: RE:R-HSA-380751 +xref: RE:R-HSA-380759 +xref: RE:R-HSA-381935 +xref: RE:R-HSA-381938 +xref: RE:R-HSA-387074 +xref: RE:R-HSA-392712 +is_a: FPLX:000000 ! famplex +relationship: has_part HGNC:8800 ! PDGFB + +[Term] +id: FPLX:000350 +name: PDGF-CC +synonym: "PDGF CC" EXACT [] +synonym: "PDGF-CC" EXACT [] +synonym: "PDGF-cc" EXACT [] +xref: RE:R-HSA-381941 +is_a: FPLX:000000 ! famplex +relationship: has_part HGNC:8801 ! PDGFC + +[Term] +id: FPLX:000351 +name: PDGF-DD +synonym: "PDGF DD" EXACT [] +synonym: "PDGF-DD" EXACT [] +synonym: "PDGF-dd" EXACT [] +xref: RE:R-HSA-381930 +is_a: FPLX:000000 ! famplex +relationship: has_part HGNC:30620 ! PDGFD + +[Term] +id: FPLX:000352 +name: PDH +synonym: "PDH" EXACT [] +synonym: "pyruvate dehydrogenase (acetyl-transferring)" EXACT [] +xref: BEL:"Pyruvate Dehydrogenase Complex" +is_a: FPLX:000000 ! famplex +relationship: has_part HGNC:2896 ! DLAT +relationship: has_part HGNC:2898 ! DLD +relationship: has_part HGNC:8806 ! PDHA1 +relationship: has_part HGNC:8807 ! PDHA2 +relationship: has_part HGNC:8808 ! PDHB +relationship: has_part HGNC:21350 ! PDHX + +[Term] +id: FPLX:000353 +name: PDK +synonym: "PDK" EXACT [] +synonym: "PDKs" EXACT [] +synonym: "Pyruvate dehydrogenase kinase" EXACT [] +synonym: "pyruvate dehydrogenase kinase" EXACT [] +xref: BEL:"PDK Family" +xref: ECCODE:1.2.4.1 +xref: RE:R-HSA-203947 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:8809 ! PDK1 +relationship: inverse_is_a HGNC:8810 ! PDK2 +relationship: inverse_is_a HGNC:8811 ! PDK3 +relationship: inverse_is_a HGNC:8812 ! PDK4 + +[Term] +id: FPLX:000354 +name: Pertussis-toxin +synonym: "Pertussis toxin" EXACT [] +synonym: "pertussis toxin" EXACT [] +synonym: "PTX" EXACT [] +xref: NCIT:C736 +is_a: FPLX:000000 ! famplex + +[Term] +id: FPLX:000355 +name: PFN +synonym: "Profilin" EXACT [] +synonym: "profilin" EXACT [] +synonym: "Profilins" EXACT [] +synonym: "profilins" EXACT [] +xref: BEL:"PFN Family" +xref: IP:IPR005455 +xref: MEDSCAN:urn:agi-protfc:profilin +xref: XFAM:PF00235 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:8881 ! PFN1 +relationship: inverse_is_a HGNC:8882 ! PFN2 +relationship: inverse_is_a HGNC:18627 ! PFN3 +relationship: inverse_is_a HGNC:31103 ! PFN4 + +[Term] +id: FPLX:000356 +name: PhK +synonym: "PhK" EXACT [] +synonym: "Phosphorylase kinase" EXACT [] +synonym: "phosphorylase kinase" EXACT [] +xref: BEL:"Phosphorylase B Kinase Complex" +xref: ECCODE:2.7.11.19 +is_a: FPLX:000000 ! famplex +relationship: has_part HGNC:1442 ! CALM1 +relationship: has_part HGNC:8925 ! PHKA1 +relationship: has_part HGNC:8926 ! PHKA2 +relationship: has_part HGNC:8927 ! PHKB +relationship: has_part HGNC:8930 ! PHKG1 +relationship: has_part HGNC:8931 ! PHKG2 + +[Term] +id: FPLX:000357 +name: Phosphatase +synonym: "phosphatase" EXACT [] +xref: MESH:D010749 +xref: NCIT:C16981 +is_a: FPLX:000000 ! famplex + +[Term] +id: FPLX:000358 +name: PI3K +synonym: "phosphatidylinositol 3-kinase" EXACT [] +synonym: "PI 3-kinase" EXACT [] +synonym: "PI 3-kinases" EXACT [] +synonym: "PI3-kinase" EXACT [] +synonym: "PI3K" EXACT [] +synonym: "PI3Kinase" EXACT [] +xref: BEL:"p85/p110 PI3Kinase Complex" +xref: MEDSCAN:urn:agi-aopfc:0000447 +xref: MEDSCAN:urn:agi-complex:prophash-285b9ff3749679e4d6266406a20973aa +xref: NCIT:C17270 +is_a: FPLX:000000 ! famplex +relationship: has_part FPLX:000359 ! PI3K_p110 +relationship: has_part FPLX:000361 ! PIK3R_I + +[Term] +id: FPLX:000359 +name: PI3K-p110 +synonym: "p110" EXACT [] +synonym: "PI3K p110 subunit" EXACT [] +synonym: "PIK3C" EXACT [] +xref: BEL:"PIK3C Class IA Family" +xref: IP:IPR003113 +relationship: part_of FPLX:000358 ! PI3K +relationship: inverse_is_a HGNC:8975 ! PIK3CA +relationship: inverse_is_a HGNC:8976 ! PIK3CB +relationship: inverse_is_a HGNC:8977 ! PIK3CD +relationship: inverse_is_a HGNC:8978 ! PIK3CG + +[Term] +id: FPLX:000360 +name: PI3K-p85 +synonym: "p85" EXACT [] +xref: RE:R-HSA-74688 +is_a: FPLX:000361 ! PIK3R_I +relationship: inverse_is_a HGNC:8979 ! PIK3R1 +relationship: inverse_is_a HGNC:8980 ! PIK3R2 + +[Term] +id: FPLX:000361 +name: PIK3R-I +synonym: "PIK3R" EXACT [] +xref: BEL:"PIK3R Class IA Family" +relationship: part_of FPLX:000358 ! PI3K +relationship: inverse_is_a HGNC:8981 ! PIK3R3 +relationship: inverse_is_a HGNC:8982 ! PIK3R4 +relationship: inverse_is_a HGNC:30035 ! PIK3R5 +relationship: inverse_is_a HGNC:27101 ! PIK3R6 +relationship: inverse_is_a FPLX:000360 ! PI3K_p85 + +[Term] +id: FPLX:000362 +name: PIM +synonym: "PIM" EXACT [] +xref: IP:IPR017348 +xref: NEXTPROT-FAMILY:03078 +xref: SIGNOR:SIGNOR-PF34 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:8986 ! PIM1 +relationship: inverse_is_a HGNC:8987 ! PIM2 +relationship: inverse_is_a HGNC:19310 ! PIM3 + +[Term] +id: FPLX:000363 +name: PKA +synonym: "cAMP-dependent PK" EXACT [] +synonym: "cAMP-dependent protein kinase" EXACT [] +synonym: "cyclic AMP-dependent protein kinase" EXACT [] +synonym: "cyclic-AMP-dependent protein kinase" EXACT [] +synonym: "PK-A" EXACT [] +synonym: "PKA" EXACT [] +synonym: "protein kinase A" EXACT [] +xref: ECCODE:2.7.11.11 +xref: NCIT:C16479 +is_a: FPLX:000000 ! famplex +relationship: has_part FPLX:000390 ! PRKAR +relationship: has_part FPLX:000389 ! PRKAC + +[Term] +id: FPLX:000364 +name: PKC +synonym: "PKC" EXACT [] +synonym: "protein kinase C" EXACT [] +xref: BEL:"PRKC Family" +xref: ECCODE:2.7.11.13 +xref: IP:IPR012233 +xref: MESH:D011493 +xref: NCIT:C17017 +xref: NEXTPROT-FAMILY:03065 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:9393 ! PRKCA +relationship: inverse_is_a HGNC:9395 ! PRKCB +relationship: inverse_is_a HGNC:9399 ! PRKCD +relationship: inverse_is_a HGNC:9401 ! PRKCE +relationship: inverse_is_a HGNC:9402 ! PRKCG +relationship: inverse_is_a HGNC:9403 ! PRKCH +relationship: inverse_is_a HGNC:9404 ! PRKCI +relationship: inverse_is_a HGNC:9410 ! PRKCQ +relationship: inverse_is_a HGNC:9412 ! PRKCZ +relationship: inverse_is_a HGNC:9408 ! PRKD3 + +[Term] +id: FPLX:000365 +name: PKI +synonym: "PKI" EXACT [] +xref: BEL:"PKI Family" +xref: IP:IPR004171 +xref: XFAM:PF02827 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:9017 ! PKIA +relationship: inverse_is_a HGNC:9018 ! PKIB +relationship: inverse_is_a HGNC:9019 ! PKIG + +[Term] +id: FPLX:000366 +name: PLA2 +synonym: "cPLA2" EXACT [] +synonym: "cytosolic phospholipase A(2)" EXACT [] +synonym: "cytosolic phospholipase A2" EXACT [] +synonym: "cytosolic PLA2" EXACT [] +synonym: "phospholipase A2" EXACT [] +xref: BEL:"PLA2 Family" +xref: ECCODE:3.1.1.4 +xref: MEDSCAN:urn:agi-aopfc:0000455 +xref: MEDSCAN:urn:agi-protfc:cytosolic%20phospholipase%20a2 +xref: NCIT:C16979 +xref: NEXTPROT-FAMILY:02840 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:9030 ! PLA2G1B +relationship: inverse_is_a HGNC:17934 ! PLA2G3 +relationship: inverse_is_a HGNC:9038 ! PLA2G5 +relationship: inverse_is_a HGNC:9039 ! PLA2G6 +relationship: inverse_is_a HGNC:9040 ! PLA2G7 +relationship: inverse_is_a HGNC:9029 ! PLA2G10 +relationship: inverse_is_a HGNC:18554 ! PLA2G12A +relationship: inverse_is_a HGNC:18555 ! PLA2G12B +relationship: inverse_is_a FPLX:000367 ! PLA2G2 +relationship: inverse_is_a FPLX:000368 ! PLA2G4 + +[Term] +id: FPLX:000367 +name: PLA2G2 +synonym: "GII PLA2" EXACT [] +synonym: "GIIPLA2" EXACT [] +synonym: "phospholipase A2 group-II" EXACT [] +synonym: "PLA2G2" EXACT [] +synonym: "PLA2g2" EXACT [] +xref: BEL:"PLA2G2 Family" +is_a: FPLX:000366 ! PLA2 +relationship: inverse_is_a HGNC:9031 ! PLA2G2A +relationship: inverse_is_a HGNC:9032 ! PLA2G2C +relationship: inverse_is_a HGNC:9033 ! PLA2G2D +relationship: inverse_is_a HGNC:13414 ! PLA2G2E +relationship: inverse_is_a HGNC:30040 ! PLA2G2F + +[Term] +id: FPLX:000368 +name: PLA2G4 +synonym: "gIV-PLA(2)" EXACT [] +synonym: "group IV-PLA(2)" EXACT [] +synonym: "Phospholipase A2 Group IV" EXACT [] +synonym: "phospholipase A2 group-IV" EXACT [] +synonym: "PLA2G4" EXACT [] +xref: NCIT:C19836 +is_a: FPLX:000366 ! PLA2 +relationship: inverse_is_a HGNC:9035 ! PLA2G4A +relationship: inverse_is_a HGNC:9037 ! PLA2G4C +relationship: inverse_is_a HGNC:30038 ! PLA2G4D + +[Term] +id: FPLX:000369 +name: PLC +synonym: "Phospholipase C" EXACT [] +synonym: "phospholipase C" EXACT [] +synonym: "Phospholipase-C" EXACT [] +synonym: "phospholipase-C" EXACT [] +synonym: "PLC" EXACT [] +xref: BEL:"PLC Family" +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:17175 ! PLCE1 +relationship: inverse_is_a HGNC:19218 ! PLCZ1 +relationship: inverse_is_a FPLX:000370 ! PLCB +relationship: inverse_is_a FPLX:000371 ! PLCD +relationship: inverse_is_a FPLX:000372 ! PLCG + +[Term] +id: FPLX:000370 +name: PLCB +synonym: "Phospholipase C-beta" EXACT [] +synonym: "phospholipase C-beta" EXACT [] +synonym: "Phospholipase C-β" EXACT [] +synonym: "phospholipase C-β" EXACT [] +synonym: "Phospholipase Cbeta" EXACT [] +synonym: "phospholipase Cbeta" EXACT [] +synonym: "Phospholipase Cβ" EXACT [] +synonym: "phospholipase Cβ" EXACT [] +xref: BEL:"PLCB Family" +xref: IP:IPR016280 +xref: RE:R-HSA-111854 +is_a: FPLX:000369 ! PLC +relationship: inverse_is_a HGNC:15917 ! PLCB1 +relationship: inverse_is_a HGNC:9055 ! PLCB2 +relationship: inverse_is_a HGNC:9056 ! PLCB3 +relationship: inverse_is_a HGNC:9059 ! PLCB4 + +[Term] +id: FPLX:000371 +name: PLCD +synonym: "Phospholipase C-delta" EXACT [] +synonym: "phospholipase C-delta" EXACT [] +synonym: "Phospholipase C-δ" EXACT [] +synonym: "phospholipase C-δ" EXACT [] +synonym: "Phospholipase Cdelta" EXACT [] +synonym: "phospholipase Cdelta" EXACT [] +synonym: "Phospholipase Cδ" EXACT [] +synonym: "phospholipase Cδ" EXACT [] +is_a: FPLX:000369 ! PLC +relationship: inverse_is_a HGNC:9060 ! PLCD1 +relationship: inverse_is_a HGNC:9061 ! PLCD3 +relationship: inverse_is_a HGNC:9062 ! PLCD4 + +[Term] +id: FPLX:000372 +name: PLCG +synonym: "PLC-gamma" EXACT [] +synonym: "PLC-γ" EXACT [] +xref: BEL:"PLCG Family" +xref: IP:IPR016279 +xref: IP:IPR035023 +xref: IP:IPR035024 +xref: NCIT:C126114 +xref: RE:R-HSA-1168365 +xref: RE:R-HSA-1169086 +xref: RE:R-HSA-1169089 +xref: RE:R-HSA-2029095 +xref: RE:R-HSA-2685653 +is_a: FPLX:000369 ! PLC +relationship: inverse_is_a HGNC:9065 ! PLCG1 +relationship: inverse_is_a HGNC:9066 ! PLCG2 + +[Term] +id: FPLX:000373 +name: PLD +synonym: "Phospholipase D" EXACT [] +synonym: "phospholipase D" EXACT [] +xref: BEL:"PLD Family" +xref: ECCODE:3.1.4.4 +xref: IP:IPR015679 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:9067 ! PLD1 +relationship: inverse_is_a HGNC:9068 ! PLD2 +relationship: inverse_is_a HGNC:17158 ! PLD3 +relationship: inverse_is_a HGNC:23792 ! PLD4 +relationship: inverse_is_a HGNC:26879 ! PLD5 +relationship: inverse_is_a HGNC:30447 ! PLD6 + +[Term] +id: FPLX:000374 +name: PPAP2 +synonym: "type 2 phosphatidic acid phosphatase" EXACT [] +synonym: "type 2 phosphatidic acid phosphatases" EXACT [] +synonym: "type II phosphatidic acid phosphatase" EXACT [] +synonym: "type II phosphatidic acid phosphatases" EXACT [] +xref: BEL:"PPAP2 Family" +xref: RE:R-HSA-428110 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:9228 ! PLPP1 +relationship: inverse_is_a HGNC:9230 ! PLPP2 +relationship: inverse_is_a HGNC:9229 ! PLPP3 + +[Term] +id: FPLX:000375 +name: PPAR +synonym: "PPAR" EXACT [] +xref: BEL:"PPAR Family" +xref: IP:IPR003074 +xref: MEDSCAN:urn:agi-protfc:ppar +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:9232 ! PPARA +relationship: inverse_is_a HGNC:9235 ! PPARD +relationship: inverse_is_a HGNC:9236 ! PPARG + +[Term] +id: FPLX:000376 +name: PPP1 +synonym: "PP1 regulator" EXACT [] +synonym: "PP1" EXACT [] +synonym: "PPP1" EXACT [] +xref: GO:0008599 +xref: MEDSCAN:urn:agi-complex:prophash-d39afef40daf23ad8376b53904c7092c +xref: MEDSCAN:urn:agi-complex:protein%20phosphatase%20type%201%20complex +xref: NEXTPROT-FAMILY:03001 +is_a: FPLX:000000 ! famplex +relationship: has_part FPLX:000377 ! PPP1C +relationship: has_part FPLX:000378 ! PPP1R + +[Term] +id: FPLX:000377 +name: PPP1C +synonym: "PP1C" EXACT [] +synonym: "PP1c" EXACT [] +synonym: "PPP1C" EXACT [] +xref: BEL:"PPP1C Family" +xref: IP:IPR031675 +xref: RE:R-HSA-163538 +relationship: part_of FPLX:000376 ! PPP1 +relationship: inverse_is_a HGNC:9281 ! PPP1CA +relationship: inverse_is_a HGNC:9282 ! PPP1CB +relationship: inverse_is_a HGNC:9283 ! PPP1CC + +[Term] +id: FPLX:000378 +name: PPP1R +synonym: "PP1R" EXACT [] +synonym: "PP1r" EXACT [] +xref: BEL:"PPP1R Family" +relationship: part_of FPLX:000376 ! PPP1 +relationship: inverse_is_a HGNC:9284 ! PPP1R10 +relationship: inverse_is_a HGNC:9285 ! PPP1R11 +relationship: inverse_is_a HGNC:7618 ! PPP1R12A +relationship: inverse_is_a HGNC:7619 ! PPP1R12B +relationship: inverse_is_a HGNC:14947 ! PPP1R12C +relationship: inverse_is_a HGNC:14950 ! PPP1R13B +relationship: inverse_is_a HGNC:14871 ! PPP1R14A +relationship: inverse_is_a HGNC:9057 ! PPP1R14B +relationship: inverse_is_a HGNC:14952 ! PPP1R14C +relationship: inverse_is_a HGNC:14953 ! PPP1R14D +relationship: inverse_is_a HGNC:14375 ! PPP1R15A +relationship: inverse_is_a HGNC:14951 ! PPP1R15B +relationship: inverse_is_a HGNC:14941 ! PPP1R16A +relationship: inverse_is_a HGNC:15850 ! PPP1R16B +relationship: inverse_is_a HGNC:9286 ! PPP1R1A +relationship: inverse_is_a HGNC:9287 ! PPP1R1B +relationship: inverse_is_a HGNC:14940 ! PPP1R1C +relationship: inverse_is_a HGNC:9288 ! PPP1R2 +relationship: inverse_is_a HGNC:9291 ! PPP1R3A +relationship: inverse_is_a HGNC:14942 ! PPP1R3B +relationship: inverse_is_a HGNC:9293 ! PPP1R3C +relationship: inverse_is_a HGNC:9294 ! PPP1R3D +relationship: inverse_is_a HGNC:14944 ! PPP1R3F +relationship: inverse_is_a HGNC:9295 ! PPP1R7 +relationship: inverse_is_a HGNC:9296 ! PPP1R8 +relationship: inverse_is_a HGNC:14946 ! PPP1R9A +relationship: inverse_is_a HGNC:9298 ! PPP1R9B + +[Term] +id: FPLX:000379 +name: PPP2 +synonym: "PP2 phosphatases" EXACT [] +synonym: "PP2" EXACT [] +synonym: "PP2A" EXACT [] +synonym: "protein phosphatase 2" EXACT [] +xref: MEDSCAN:urn:agi-complex:prophash-f2e03d3bf1f747adab17ce77b9b5e5b3 +xref: MEDSCAN:urn:agi-complex:protein%20phosphatase%20type%202A%20complex +xref: RE:R-HSA-196206 +is_a: FPLX:000000 ! famplex +relationship: has_part FPLX:000380 ! PPP2C +relationship: has_part FPLX:000381 ! PPP2R_A +relationship: has_part FPLX:000382 ! PPP2R_B + +[Term] +id: FPLX:000380 +name: PPP2C +synonym: "PP2A catalytic C subunit" EXACT [] +synonym: "PP2A-C" EXACT [] +synonym: "PP2Ac" EXACT [] +xref: BEL:"PPP2C Family" +relationship: part_of FPLX:000379 ! PPP2 +relationship: inverse_is_a HGNC:20785 ! PPM1J +relationship: inverse_is_a HGNC:9299 ! PPP2CA +relationship: inverse_is_a HGNC:9300 ! PPP2CB + +[Term] +id: FPLX:000381 +name: PPP2R-A +synonym: "PP2A regulatory subunit A" EXACT [] +synonym: "regulatory A subunit of PP2A" EXACT [] +xref: BEL:"PPP2R Subunit A Family" +xref: RE:R-HSA-165990 +xref: RE:R-HSA-165997 +relationship: part_of FPLX:000379 ! PPP2 +relationship: inverse_is_a HGNC:9302 ! PPP2R1A +relationship: inverse_is_a HGNC:9303 ! PPP2R1B + +[Term] +id: FPLX:000382 +name: PPP2R-B +synonym: "PP2A regulatory subunit B" EXACT [] +synonym: "regulatory B subunit of PP2A" EXACT [] +xref: BEL:"PPP2R Subunit B Family" +relationship: part_of FPLX:000379 ! PPP2 +relationship: inverse_is_a HGNC:9304 ! PPP2R2A +relationship: inverse_is_a HGNC:9305 ! PPP2R2B +relationship: inverse_is_a HGNC:9306 ! PPP2R2C +relationship: inverse_is_a HGNC:23732 ! PPP2R2D +relationship: inverse_is_a HGNC:9307 ! PPP2R3A +relationship: inverse_is_a HGNC:13417 ! PPP2R3B +relationship: inverse_is_a HGNC:9308 ! PTPA +relationship: inverse_is_a HGNC:9309 ! PPP2R5A +relationship: inverse_is_a HGNC:9310 ! PPP2R5B +relationship: inverse_is_a HGNC:9311 ! PPP2R5C +relationship: inverse_is_a HGNC:9312 ! PPP2R5D +relationship: inverse_is_a HGNC:9313 ! PPP2R5E + +[Term] +id: FPLX:000383 +name: PPP3 +synonym: "calcineurin" EXACT [] +synonym: "CaN" EXACT [] +synonym: "PP2B" EXACT [] +synonym: "protein phosphatase 2B" EXACT [] +xref: BEL:"Calcineurin Complex" +xref: BEL:"PPP3 Family" +xref: MEDSCAN:urn:agi-complex:protein%20phosphatase%203 +is_a: FPLX:000000 ! famplex +relationship: has_part FPLX:000384 ! PPP3C +relationship: has_part FPLX:000385 ! PPP3R + +[Term] +id: FPLX:000384 +name: PPP3C +synonym: "Calcineurin catalytic subunit" EXACT [] +synonym: "catalytic subunit of calcineurin" EXACT [] +synonym: "PP2B catalytic subunit" EXACT [] +xref: BEL:"PPP3C Family" +xref: RE:R-HSA-201779 +xref: RE:R-HSA-201798 +xref: SIGNOR:SIGNOR-PF18 +relationship: part_of FPLX:000383 ! PPP3 +relationship: inverse_is_a HGNC:9314 ! PPP3CA +relationship: inverse_is_a HGNC:9315 ! PPP3CB +relationship: inverse_is_a HGNC:9316 ! PPP3CC + +[Term] +id: FPLX:000385 +name: PPP3R +synonym: "Calcineurin regulatory subunit" EXACT [] +synonym: "regulatory subunit of calcineurin" EXACT [] +xref: BEL:"PPP3R Family" +xref: NEXTPROT-FAMILY:00421 +relationship: part_of FPLX:000383 ! PPP3 +relationship: inverse_is_a HGNC:9317 ! PPP3R1 +relationship: inverse_is_a HGNC:9318 ! PPP3R2 + +[Term] +id: FPLX:000386 +name: PRC1-complex +synonym: "polycomb Repressive Complex (PRC) 1" EXACT [] +synonym: "Polycomb Repressive Complex 1" EXACT [] +synonym: "Polycomb repressive complex 1" EXACT [] +synonym: "polycomb repressive complex 1" EXACT [] +synonym: "Polycomb repressive complex PRC1" EXACT [] +synonym: "Polycomb Repressive Complexes 1" EXACT [] +synonym: "Polycomb-repressive complex 1" EXACT [] +synonym: "PRC1" EXACT [] +xref: BEL:"PRC1 Maintenance Complex" +xref: GO:0035102 +xref: MEDSCAN:urn:agi-complex:prophash-aba0c4130764ae7a26054736114e65cd +xref: NCIT:C19866 +is_a: FPLX:000000 ! famplex +relationship: has_part HGNC:1066 ! BMI1 +relationship: has_part HGNC:1552 ! CBX2 +relationship: has_part HGNC:1554 ! CBX4 +relationship: has_part HGNC:15962 ! CBX8 +relationship: has_part HGNC:12929 ! PCGF2 +relationship: has_part HGNC:3182 ! PHC1 +relationship: has_part HGNC:3183 ! PHC2 +relationship: has_part HGNC:15682 ! PHC3 +relationship: has_part HGNC:8919 ! PHF1 +relationship: has_part HGNC:10018 ! RING1 +relationship: has_part HGNC:10061 ! RNF2 +relationship: has_part HGNC:19003 ! SCMH1 +relationship: has_part HGNC:12856 ! YY1 +relationship: has_part HGNC:12918 ! ZNF134 + +[Term] +id: FPLX:000387 +name: PRC2-complex +synonym: "Polycomb Repressive Complex 2" EXACT [] +synonym: "Polycomb repressive complex 2" EXACT [] +synonym: "polycomb repressive complex 2" EXACT [] +synonym: "Polycomb repressive complex PRC2" EXACT [] +synonym: "Polycomb Repressive Complexes 2" EXACT [] +synonym: "Polycomb-repressive complex 2" EXACT [] +synonym: "PRC2" EXACT [] +xref: BEL:"PRC2 Initiation Complex" +xref: GO:0035098 +xref: MEDSCAN:urn:agi-complex:prophash-2b612daa76feb2db86ff39e70449df6b +is_a: FPLX:000000 ! famplex +relationship: has_part HGNC:3188 ! EED +relationship: has_part HGNC:3526 ! EZH1 +relationship: has_part HGNC:3527 ! EZH2 +relationship: has_part HGNC:17101 ! SUZ12 + +[Term] +id: FPLX:000388 +name: PRDX +synonym: "Peroxiredoxin" EXACT [] +synonym: "peroxiredoxin" EXACT [] +synonym: "Peroxiredoxins" EXACT [] +synonym: "peroxiredoxins" EXACT [] +xref: BEL:"PRDX Family" +xref: ECCODE:1.11.1.15 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:9352 ! PRDX1 +relationship: inverse_is_a HGNC:9353 ! PRDX2 +relationship: inverse_is_a HGNC:9354 ! PRDX3 +relationship: inverse_is_a HGNC:17169 ! PRDX4 +relationship: inverse_is_a HGNC:9355 ! PRDX5 +relationship: inverse_is_a HGNC:16753 ! PRDX6 + +[Term] +id: FPLX:000389 +name: PRKAC +synonym: "PKA catalytic subunit" EXACT [] +synonym: "PKA catalytic subunits" EXACT [] +synonym: "Protein kinase A catalytic subunit" EXACT [] +synonym: "protein kinase A catalytic subunit" EXACT [] +synonym: "Protein kinase A catalytic subunits" EXACT [] +synonym: "protein kinase A catalytic subunits" EXACT [] +xref: BEL:"PRKA Family" +xref: SIGNOR:SIGNOR-PF17 +relationship: part_of FPLX:000363 ! PKA +relationship: inverse_is_a HGNC:9380 ! PRKACA +relationship: inverse_is_a HGNC:9381 ! PRKACB +relationship: inverse_is_a HGNC:9382 ! PRKACG + +[Term] +id: FPLX:000390 +name: PRKAR +synonym: "PKA regulatory subunit" EXACT [] +synonym: "PKA regulatory subunits" EXACT [] +synonym: "Protein kinase A regulatory subunit" EXACT [] +synonym: "protein kinase A regulatory subunit" EXACT [] +synonym: "Protein kinase A regulatory subunits" EXACT [] +synonym: "protein kinase A regulatory subunits" EXACT [] +synonym: "rPKA" EXACT [] +xref: BEL:"PRKAR Family" +xref: IP:IPR012198 +xref: RE:R-HSA-111921 +xref: RE:R-HSA-111923 +xref: RE:R-HSA-5610566 +xref: RE:R-HSA-5610568 +relationship: part_of FPLX:000363 ! PKA +relationship: inverse_is_a HGNC:9388 ! PRKAR1A +relationship: inverse_is_a HGNC:9390 ! PRKAR1B +relationship: inverse_is_a HGNC:9391 ! PRKAR2A +relationship: inverse_is_a HGNC:9392 ! PRKAR2B + +[Term] +id: FPLX:000391 +name: PRKG +synonym: "PKG" EXACT [] +synonym: "protein kinase G" EXACT [] +xref: BEL:"PRKG Family" +xref: ECCODE:2.7.11.12 +xref: IP:IPR002374 +xref: IP:IPR035014 +xref: RE:R-HSA-418379 +xref: RE:R-HSA-4551456 +xref: RE:R-HSA-4551462 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:9414 ! PRKG1 +relationship: inverse_is_a HGNC:9416 ! PRKG2 + +[Term] +id: FPLX:000392 +name: Propionyl-CoA-carboxylase +synonym: "Propionyl-CoA carboxylase" EXACT [] +synonym: "propionyl-CoA carboxylase" EXACT [] +xref: BEL:"Propionyl CoA Carboxylase Complex" +xref: ECCODE:6.4.1.3 +xref: RE:R-HSA-2993807 +xref: RE:R-HSA-2993809 +xref: RE:R-HSA-3323122 +xref: RE:R-HSA-3323155 +xref: RE:R-HSA-71025 +xref: RE:R-HSA-71026 +is_a: FPLX:000000 ! famplex +relationship: has_part HGNC:8653 ! PCCA +relationship: has_part HGNC:8654 ! PCCB + +[Term] +id: FPLX:000393 +name: Protease +synonym: "protease" EXACT [] +xref: NCIT:C16965 +is_a: FPLX:000000 ! famplex + +[Term] +id: FPLX:000394 +name: Proteasome +synonym: "proteasome endopeptidase" EXACT [] +synonym: "proteasome" EXACT [] +xref: BEL:"Proteasome Complex" +xref: ECCODE:3.4.25.1 +xref: GO:0000502 +xref: MESH:D046988 +is_a: FPLX:000000 ! famplex +relationship: has_part HGNC:9530 ! PSMA1 +relationship: has_part HGNC:9531 ! PSMA2 +relationship: has_part HGNC:9532 ! PSMA3 +relationship: has_part HGNC:9533 ! PSMA4 +relationship: has_part HGNC:9534 ! PSMA5 +relationship: has_part HGNC:9535 ! PSMA6 +relationship: has_part HGNC:9536 ! PSMA7 +relationship: has_part HGNC:22985 ! PSMA8 +relationship: has_part HGNC:9537 ! PSMB1 +relationship: has_part HGNC:9538 ! PSMB10 +relationship: has_part HGNC:9539 ! PSMB2 +relationship: has_part HGNC:9540 ! PSMB3 +relationship: has_part HGNC:9541 ! PSMB4 +relationship: has_part HGNC:9542 ! PSMB5 +relationship: has_part HGNC:9543 ! PSMB6 +relationship: has_part HGNC:9544 ! PSMB7 +relationship: has_part HGNC:9545 ! PSMB8 +relationship: has_part HGNC:9546 ! PSMB9 +relationship: has_part HGNC:9547 ! PSMC1 +relationship: has_part HGNC:9548 ! PSMC2 +relationship: has_part HGNC:9549 ! PSMC3 +relationship: has_part HGNC:9551 ! PSMC4 +relationship: has_part HGNC:9552 ! PSMC5 +relationship: has_part HGNC:9553 ! PSMC6 +relationship: has_part HGNC:9554 ! PSMD1 +relationship: has_part HGNC:9555 ! PSMD10 +relationship: has_part HGNC:9556 ! PSMD11 +relationship: has_part HGNC:9557 ! PSMD12 +relationship: has_part HGNC:9558 ! PSMD13 +relationship: has_part HGNC:16889 ! PSMD14 +relationship: has_part HGNC:9559 ! PSMD2 +relationship: has_part HGNC:9560 ! PSMD3 +relationship: has_part HGNC:9561 ! PSMD4 +relationship: has_part HGNC:9563 ! PSMD5 +relationship: has_part HGNC:9564 ! PSMD6 +relationship: has_part HGNC:9565 ! PSMD7 +relationship: has_part HGNC:9566 ! PSMD8 +relationship: has_part HGNC:9567 ! PSMD9 +relationship: has_part HGNC:9568 ! PSME1 +relationship: has_part HGNC:9569 ! PSME2 +relationship: has_part HGNC:9570 ! PSME3 +relationship: has_part HGNC:9571 ! PSMF1 +relationship: has_part HGNC:10845 ! SEM1 +relationship: has_part HGNC:12628 ! USP5 + +[Term] +id: FPLX:000395 +name: PTGER +synonym: "prostaglandin E receptor" EXACT [] +xref: BEL:"PTGER Family" +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:9593 ! PTGER1 +relationship: inverse_is_a HGNC:9594 ! PTGER2 +relationship: inverse_is_a HGNC:9595 ! PTGER3 +relationship: inverse_is_a HGNC:9596 ! PTGER4 + +[Term] +id: FPLX:000396 +name: PYG +synonym: "Glycogen phosphorylase" EXACT [] +synonym: "Glycogen phosphorylases" EXACT [] +synonym: "glycogen phosphorylase" EXACT [] +synonym: "glycogen phosphorylases" EXACT [] +synonym: "PYG" EXACT [] +is_a: FPLX:000198 ! Glycosyltransferase +relationship: inverse_is_a HGNC:9723 ! PYGB +relationship: inverse_is_a HGNC:9725 ! PYGL +relationship: inverse_is_a HGNC:9726 ! PYGM + +[Term] +id: FPLX:000397 +name: RAB +synonym: "Rab GTPase" EXACT [] +synonym: "Rab GTPases" EXACT [] +synonym: "rab GTPases" EXACT [] +synonym: "rab proteins" EXACT [] +synonym: "RAB" EXACT [] +synonym: "Rab" EXACT [] +synonym: "rab" EXACT [] +synonym: "Rabs" EXACT [] +xref: BEL:"RAB Family" +xref: MEDSCAN:urn:agi-protfc:rab +xref: NEXTPROT-FAMILY:03661 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:9759 ! RAB10 +relationship: inverse_is_a HGNC:9760 ! RAB11A +relationship: inverse_is_a HGNC:9761 ! RAB11B +relationship: inverse_is_a HGNC:31332 ! RAB12 +relationship: inverse_is_a HGNC:9762 ! RAB13 +relationship: inverse_is_a HGNC:16524 ! RAB14 +relationship: inverse_is_a HGNC:20150 ! RAB15 +relationship: inverse_is_a HGNC:16523 ! RAB17 +relationship: inverse_is_a HGNC:14244 ! RAB18 +relationship: inverse_is_a HGNC:19982 ! RAB19 +relationship: inverse_is_a HGNC:9758 ! RAB1A +relationship: inverse_is_a HGNC:18370 ! RAB1B +relationship: inverse_is_a HGNC:23683 ! RAB1C +relationship: inverse_is_a HGNC:18260 ! RAB20 +relationship: inverse_is_a HGNC:18263 ! RAB21 +relationship: inverse_is_a HGNC:9764 ! RAB22A +relationship: inverse_is_a HGNC:14263 ! RAB23 +relationship: inverse_is_a HGNC:9765 ! RAB24 +relationship: inverse_is_a HGNC:18238 ! RAB25 +relationship: inverse_is_a HGNC:14259 ! RAB26 +relationship: inverse_is_a HGNC:9766 ! RAB27A +relationship: inverse_is_a HGNC:9767 ! RAB27B +relationship: inverse_is_a HGNC:9768 ! RAB28 +relationship: inverse_is_a HGNC:9763 ! RAB2A +relationship: inverse_is_a HGNC:20246 ! RAB2B +relationship: inverse_is_a HGNC:9770 ! RAB30 +relationship: inverse_is_a HGNC:9771 ! RAB31 +relationship: inverse_is_a HGNC:9772 ! RAB32 +relationship: inverse_is_a HGNC:9773 ! RAB33A +relationship: inverse_is_a HGNC:16075 ! RAB33B +relationship: inverse_is_a HGNC:16519 ! RAB34 +relationship: inverse_is_a HGNC:9774 ! RAB35 +relationship: inverse_is_a HGNC:9775 ! RAB36 +relationship: inverse_is_a HGNC:30268 ! RAB37 +relationship: inverse_is_a HGNC:9776 ! RAB38 +relationship: inverse_is_a HGNC:16521 ! RAB39A +relationship: inverse_is_a HGNC:16499 ! RAB39B +relationship: inverse_is_a HGNC:9777 ! RAB3A +relationship: inverse_is_a HGNC:9778 ! RAB3B +relationship: inverse_is_a HGNC:30269 ! RAB3C +relationship: inverse_is_a HGNC:9779 ! RAB3D +relationship: inverse_is_a HGNC:18283 ! RAB40A +relationship: inverse_is_a HGNC:25410 ! RAB40AL +relationship: inverse_is_a HGNC:18284 ! RAB40B +relationship: inverse_is_a HGNC:18285 ! RAB40C +relationship: inverse_is_a HGNC:18293 ! RAB41 +relationship: inverse_is_a HGNC:28702 ! RAB42 +relationship: inverse_is_a HGNC:19983 ! RAB43 +relationship: inverse_is_a HGNC:21068 ! RAB44 +relationship: inverse_is_a HGNC:9781 ! RAB4A +relationship: inverse_is_a HGNC:9782 ! RAB4B +relationship: inverse_is_a HGNC:9783 ! RAB5A +relationship: inverse_is_a HGNC:9784 ! RAB5B +relationship: inverse_is_a HGNC:9785 ! RAB5C +relationship: inverse_is_a HGNC:9786 ! RAB6A +relationship: inverse_is_a HGNC:14902 ! RAB6B +relationship: inverse_is_a HGNC:16525 ! RAB6C +relationship: inverse_is_a HGNC:9788 ! RAB7A +relationship: inverse_is_a HGNC:30513 ! RAB7B +relationship: inverse_is_a HGNC:9789 ! RAB29 +relationship: inverse_is_a HGNC:7007 ! RAB8A +relationship: inverse_is_a HGNC:30273 ! RAB8B +relationship: inverse_is_a HGNC:9792 ! RAB9A +relationship: inverse_is_a HGNC:14090 ! RAB9B +relationship: inverse_is_a HGNC:9799 ! RABL2A +relationship: inverse_is_a HGNC:9800 ! RABL2B +relationship: inverse_is_a HGNC:18072 ! RABL3 +relationship: inverse_is_a HGNC:21895 ! IFT22 + +[Term] +id: FPLX:000398 +name: RAC +synonym: "RAC" EXACT [] +xref: BEL:"RAC Family" +xref: NEXTPROT-FAMILY:03066 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:9801 ! RAC1 +relationship: inverse_is_a HGNC:9802 ! RAC2 +relationship: inverse_is_a HGNC:9803 ! RAC3 +relationship: inverse_is_a HGNC:672 ! RHOG + +[Term] +id: FPLX:000399 +name: RAF +synonym: "RAF" EXACT [] +synonym: "Raf" EXACT [] +xref: BEL:"RAF Family" +xref: NEXTPROT-FAMILY:03114 +xref: RE:R-HSA-5672708 +xref: RE:R-HSA-5672726 +xref: RE:R-HSA-5674134 +xref: RE:R-HSA-5674136 +is_a: FPLX:000282 ! MAP3K +relationship: inverse_is_a HGNC:646 ! ARAF +relationship: inverse_is_a HGNC:1097 ! BRAF +relationship: inverse_is_a HGNC:9829 ! RAF1 + +[Term] +id: FPLX:000400 +name: RAL +synonym: "RAL family" EXACT [] +synonym: "Ral family" EXACT [] +synonym: "RAL isoforms" EXACT [] +synonym: "Ral isoforms" EXACT [] +synonym: "RAL proteins" EXACT [] +synonym: "Ral proteins" EXACT [] +synonym: "RAL" EXACT [] +xref: IP:IPR028412 +xref: RE:R-HSA-170994 +xref: RE:R-HSA-170998 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:9839 ! RALA +relationship: inverse_is_a HGNC:9840 ! RALB + +[Term] +id: FPLX:000401 +name: RAP1 +synonym: "Rap1" EXACT [] +xref: NEXTPROT-FAMILY:04773 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:9855 ! RAP1A +relationship: inverse_is_a HGNC:9857 ! RAP1B + +[Term] +id: FPLX:000402 +name: RAPGEF +synonym: "Rap guanine nucleotide exchange factor" EXACT [] +synonym: "Rap guanine nucleotide exchange factors" EXACT [] +synonym: "RapGEFs" EXACT [] +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:4568 ! RAPGEF1 +relationship: inverse_is_a HGNC:16854 ! RAPGEF2 + +[Term] +id: FPLX:000403 +name: RAR +synonym: "RAR" EXACT [] +synonym: "retinoic acid receptors" EXACT [] +xref: BEL:"RAR Family" +xref: NCIT:C17532 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:9864 ! RARA +relationship: inverse_is_a HGNC:9865 ! RARB +relationship: inverse_is_a HGNC:9866 ! RARG + +[Term] +id: FPLX:000404 +name: RAS +synonym: "Ras GTPase" EXACT [] +synonym: "RAS" EXACT [] +synonym: "Ras" EXACT [] +xref: BEL:"RAS Family" +xref: MEDSCAN:urn:agi-aopfc:0000465 +xref: NCIT:C17061 +xref: NEXTPROT-FAMILY:03663 +xref: XFAM:PF00071 +xref: RE:R-HSA-109782 +xref: RE:R-HSA-109783 +xref: RE:R-HSA-109796 +xref: RE:R-HSA-167204 +xref: RE:R-HSA-6802607 +xref: RE:R-HSA-6802608 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:6407 ! KRAS +relationship: inverse_is_a HGNC:5173 ! HRAS +relationship: inverse_is_a HGNC:7989 ! NRAS + +[Term] +id: FPLX:000405 +name: RASA +synonym: "RASA" EXACT [] +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:9871 ! RASA1 +relationship: inverse_is_a HGNC:9872 ! RASA2 +relationship: inverse_is_a HGNC:20331 ! RASA3 + +[Term] +id: FPLX:000406 +name: RASAL +synonym: "RASAL" EXACT [] +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:9873 ! RASAL1 +relationship: inverse_is_a HGNC:9874 ! RASAL2 +relationship: inverse_is_a HGNC:26129 ! RASAL3 + +[Term] +id: FPLX:000407 +name: RasGAP +synonym: "RasGAP" EXACT [] +synonym: "RasGAPs" EXACT [] +xref: XFAM:PF00616 +xref: RE:R-HSA-5658216 +is_a: FPLX:000000 ! famplex + +[Term] +id: FPLX:000408 +name: RASGRF +synonym: "RASGRF" EXACT [] +xref: RE:R-HSA-442734 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:9875 ! RASGRF1 +relationship: inverse_is_a HGNC:9876 ! RASGRF2 + +[Term] +id: FPLX:000409 +name: RASGRP +synonym: "RASGRP" EXACT [] +xref: RE:R-HSA-2685656 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:9878 ! RASGRP1 +relationship: inverse_is_a HGNC:9879 ! RASGRP2 +relationship: inverse_is_a HGNC:14545 ! RASGRP3 +relationship: inverse_is_a HGNC:18958 ! RASGRP4 + +[Term] +id: FPLX:000410 +name: RASSF +synonym: "RAS association domain family" EXACT [] +synonym: "Ras association domain family" EXACT [] +synonym: "RAS-association domain family" EXACT [] +synonym: "Ras-association domain family" EXACT [] +synonym: "RASSF family" EXACT [] +xref: IP:IPR033614 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:9882 ! RASSF1 +relationship: inverse_is_a HGNC:9883 ! RASSF2 +relationship: inverse_is_a HGNC:14271 ! RASSF3 +relationship: inverse_is_a HGNC:20793 ! RASSF4 +relationship: inverse_is_a HGNC:17609 ! RASSF5 +relationship: inverse_is_a HGNC:20796 ! RASSF6 +relationship: inverse_is_a HGNC:1166 ! RASSF7 +relationship: inverse_is_a HGNC:13232 ! RASSF8 +relationship: inverse_is_a HGNC:15739 ! RASSF9 +relationship: inverse_is_a HGNC:33984 ! RASSF10 + +[Term] +id: FPLX:000411 +name: RFC +synonym: "DNA replication factor C complex" EXACT [] +synonym: "DNA replication factor C" EXACT [] +synonym: "replication factor C" EXACT [] +synonym: "RF-C" EXACT [] +synonym: "RFC" EXACT [] +xref: BEL:"RFC Complex" +xref: GO:0005663 +xref: MEDSCAN:urn:agi-complex:prophash-7629c2cdfdf4908b72f13917a7c1551e +xref: RE:R-HSA-174454 +xref: RE:R-HSA-68436 +is_a: FPLX:000000 ! famplex +relationship: has_part HGNC:9969 ! RFC1 +relationship: has_part HGNC:9970 ! RFC2 +relationship: has_part HGNC:9971 ! RFC3 +relationship: has_part HGNC:9972 ! RFC4 +relationship: has_part HGNC:9973 ! RFC5 + +[Term] +id: FPLX:000412 +name: RFX +synonym: "regulatory family X" EXACT [] +synonym: "RF-X" EXACT [] +synonym: "RFX family" EXACT [] +synonym: "RFX proteins" EXACT [] +synonym: "RFX" EXACT [] +xref: BEL:"RFX Family" +xref: MEDSCAN:urn:agi-aopfc:0000157 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:9982 ! RFX1 +relationship: inverse_is_a HGNC:9983 ! RFX2 +relationship: inverse_is_a HGNC:9984 ! RFX3 +relationship: inverse_is_a HGNC:9985 ! RFX4 +relationship: inverse_is_a HGNC:9986 ! RFX5 +relationship: inverse_is_a HGNC:21478 ! RFX6 +relationship: inverse_is_a HGNC:25777 ! RFX7 +relationship: inverse_is_a HGNC:37253 ! RFX8 + +[Term] +id: FPLX:000413 +name: RGL +synonym: "RAL guanine nucleotide dissociation stimulator like" EXACT [] +synonym: "Ral guanine nucleotide dissociation stimulator like" EXACT [] +synonym: "ral guanine nucleotide dissociation stimulator like" EXACT [] +synonym: "RALGDS-like" EXACT [] +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:30281 ! RGL1 +relationship: inverse_is_a HGNC:9769 ! RGL2 +relationship: inverse_is_a HGNC:30282 ! RGL3 + +[Term] +id: FPLX:000414 +name: RHO +synonym: "Rho family" EXACT [] +synonym: "RHO" EXACT [] +xref: BEL:"RHO Family" +xref: MEDSCAN:urn:agi-aopfc:0000499 +xref: NEXTPROT-FAMILY:03668 +xref: RE:R-HSA-419160 +xref: RE:R-HSA-419161 +xref: RE:R-HSA-419164 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:667 ! RHOA +relationship: inverse_is_a HGNC:668 ! RHOB +relationship: inverse_is_a HGNC:669 ! RHOC + +[Term] +id: FPLX:000415 +name: RhoGDI +synonym: "Rho-GDI" EXACT [] +synonym: "RHOGDI" EXACT [] +synonym: "RhoGDI" EXACT [] +synonym: "rhoGDI" EXACT [] +synonym: "RhoGDIs" EXACT [] +xref: GO:0005094 +xref: IP:IPR000406 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:678 ! ARHGDIA +relationship: inverse_is_a HGNC:679 ! ARHGDIB +relationship: inverse_is_a HGNC:680 ! ARHGDIG + +[Term] +id: FPLX:000416 +name: RNApo-I +synonym: "Pol I" EXACT [] +synonym: "RNA polymerase 1" EXACT [] +synonym: "RNA polymerase I" EXACT [] +xref: BEL:"RNApo I Complex" +xref: GO:0005736 +xref: NCIT:C95947 +is_a: FPLX:000000 ! famplex +relationship: has_part HGNC:17264 ! POLR1A +relationship: has_part HGNC:20454 ! POLR1B +relationship: has_part HGNC:20194 ! POLR1C +relationship: has_part HGNC:20422 ! POLR1D + +[Term] +id: FPLX:000417 +name: RNApo-II +synonym: "RNA polymerase II" EXACT [] +synonym: "RNAP II" EXACT [] +xref: BEL:"RNApo II Complex" +xref: GO:0005665 +xref: MEDSCAN:urn:agi-complex:prophash-d9fbae788d60df23b6be4a3ead2cbab4 +xref: NCIT:C95948 +is_a: FPLX:000000 ! famplex +relationship: has_part HGNC:9187 ! POLR2A +relationship: has_part HGNC:9188 ! POLR2B +relationship: has_part HGNC:9189 ! POLR2C +relationship: has_part HGNC:9191 ! POLR2D +relationship: has_part HGNC:9192 ! POLR2E +relationship: has_part HGNC:9193 ! POLR2F +relationship: has_part HGNC:9194 ! POLR2G +relationship: has_part HGNC:9195 ! POLR2H +relationship: has_part HGNC:9196 ! POLR2I +relationship: has_part HGNC:9197 ! POLR2J +relationship: has_part HGNC:23208 ! POLR2J2 +relationship: has_part HGNC:9198 ! POLR2K +relationship: has_part HGNC:9199 ! POLR2L + +[Term] +id: FPLX:000418 +name: ROBO +xref: SIGNOR:SIGNOR-PF14 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:10249 ! ROBO1 +relationship: inverse_is_a HGNC:10250 ! ROBO2 +relationship: inverse_is_a HGNC:13433 ! ROBO3 + +[Term] +id: FPLX:000419 +name: ROCK +synonym: "ROCK" EXACT [] +xref: BEL:"ROCK Family" +xref: IP:IPR015008 +xref: IP:IPR020684 +xref: RE:R-HSA-419057 +xref: RE:R-HSA-4687776 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:10251 ! ROCK1 +relationship: inverse_is_a HGNC:10252 ! ROCK2 + +[Term] +id: FPLX:000420 +name: ROR +synonym: "receptor tyrosine kinase-like orphan receptor" EXACT [] +synonym: "receptor tyrosine kinase-like orphan receptors" EXACT [] +synonym: "ROR" EXACT [] +synonym: "RORs" EXACT [] +xref: BEL:"ROR Family" +xref: IP:IPR016247 +xref: MEDSCAN:urn:agi-aopfc:0000286 +xref: NEXTPROT-FAMILY:03130 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:10256 ! ROR1 +relationship: inverse_is_a HGNC:10257 ! ROR2 + +[Term] +id: FPLX:000421 +name: RPA +synonym: "Replication protein A" EXACT [] +synonym: "replication protein A" EXACT [] +synonym: "RPA" EXACT [] +xref: RE:R-HSA-68462 +is_a: FPLX:000000 ! famplex +relationship: has_part HGNC:10289 ! RPA1 +relationship: has_part HGNC:10290 ! RPA2 +relationship: has_part HGNC:10291 ! RPA3 + +[Term] +id: FPLX:000422 +name: RSK +synonym: "RSK" EXACT [] +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a FPLX:000329 ! P90RSK +relationship: inverse_is_a FPLX:000328 ! P70S6K + +[Term] +id: FPLX:000423 +name: RTK +synonym: "RTKs" EXACT [] +xref: NCIT:C17660 +is_a: FPLX:000000 ! famplex + +[Term] +id: FPLX:000424 +name: RXR +synonym: "retinoid X receptors" EXACT [] +synonym: "retinoid-X receptor" EXACT [] +synonym: "RXR" EXACT [] +xref: BEL:"RXR Family" +xref: GO:0004886 +xref: MEDSCAN:urn:agi-complex:prophash-bd459ca2937257c9e3f2b75abf22f422 +xref: NCIT:C17534 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:10477 ! RXRA +relationship: inverse_is_a HGNC:10478 ! RXRB +relationship: inverse_is_a HGNC:10479 ! RXRG + +[Term] +id: FPLX:000425 +name: S100 +synonym: "S100" EXACT [] +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a FPLX:000426 ! S100A +relationship: inverse_is_a HGNC:10500 ! S100B +relationship: inverse_is_a HGNC:1436 ! S100G +relationship: inverse_is_a HGNC:10504 ! S100P +relationship: inverse_is_a HGNC:30367 ! S100Z + +[Term] +id: FPLX:000426 +name: S100A +synonym: "S100A" EXACT [] +synonym: "S100a" EXACT [] +xref: BEL:"S100A Family" +is_a: FPLX:000425 ! S100 +relationship: inverse_is_a HGNC:20846 ! HRNR +relationship: inverse_is_a HGNC:10486 ! S100A1 +relationship: inverse_is_a HGNC:10487 ! S100A10 +relationship: inverse_is_a HGNC:10488 ! S100A11 +relationship: inverse_is_a HGNC:10489 ! S100A12 +relationship: inverse_is_a HGNC:10490 ! S100A13 +relationship: inverse_is_a HGNC:18901 ! S100A14 +relationship: inverse_is_a HGNC:20441 ! S100A16 +relationship: inverse_is_a HGNC:10492 ! S100A2 +relationship: inverse_is_a HGNC:10493 ! S100A3 +relationship: inverse_is_a HGNC:10494 ! S100A4 +relationship: inverse_is_a HGNC:10495 ! S100A5 +relationship: inverse_is_a HGNC:10496 ! S100A6 +relationship: inverse_is_a HGNC:10497 ! S100A7 +relationship: inverse_is_a HGNC:21657 ! S100A7A +relationship: inverse_is_a HGNC:10498 ! S100A8 +relationship: inverse_is_a HGNC:10499 ! S100A9 +relationship: inverse_is_a HGNC:31796 ! TCHHL1 + +[Term] +id: FPLX:000427 +name: S1PR +synonym: "S1P receptor" EXACT [] +synonym: "S1PR" EXACT [] +synonym: "Sphingosine 1-phosphate receptor" EXACT [] +synonym: "sphingosine-1-phosphate receptors" EXACT [] +xref: BEL:"S1PR Family" +xref: GO:0038036 +xref: IP:IPR004061 +xref: RE:R-HSA-419346 +xref: RE:R-HSA-419401 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:3165 ! S1PR1 +relationship: inverse_is_a HGNC:3169 ! S1PR2 +relationship: inverse_is_a HGNC:3167 ! S1PR3 +relationship: inverse_is_a HGNC:3170 ! S1PR4 +relationship: inverse_is_a HGNC:14299 ! S1PR5 + +[Term] +id: FPLX:000428 +name: SAA +synonym: "SAA" EXACT [] +xref: BEL:"SAA Family" +xref: IP:IPR000096 +xref: NEXTPROT-FAMILY:03483 +xref: XFAM:PF00277 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:10513 ! SAA1 +relationship: inverse_is_a HGNC:10514 ! SAA2 +relationship: inverse_is_a HGNC:10516 ! SAA4 + +[Term] +id: FPLX:000429 +name: SCD +synonym: "stearoyl-CoA 9-desaturase" EXACT [] +synonym: "Stearoyl-CoA desaturase" EXACT [] +synonym: "stearoyl-CoA desaturase" EXACT [] +xref: BEL:"SCD Family" +xref: ECCODE:1.14.19.1 +xref: IP:IPR001522 +xref: IP:IPR015876 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:10571 ! SCD +relationship: inverse_is_a HGNC:21088 ! SCD5 + +[Term] +id: FPLX:000430 +name: SERCA +synonym: "sarcoplasmic/endoplasmic reticulum calcium ATPase" EXACT [] +synonym: "SERCA" EXACT [] +synonym: "SERCAs" EXACT [] +synonym: "SR Ca(2+)-ATPase" EXACT [] +xref: BEL:"ATP2A Family" +xref: IP:IPR005782 +xref: MEDSCAN:urn:agi-protfc:sarcoplasmic%20reticulum%20calcium%20transporting%20adenosine%20triphosphatase +xref: RE:R-HSA-418312 +xref: RE:R-HSA-427905 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:811 ! ATP2A1 +relationship: inverse_is_a HGNC:812 ! ATP2A2 +relationship: inverse_is_a HGNC:813 ! ATP2A3 + +[Term] +id: FPLX:000431 +name: SERPINB +synonym: "Clade B serpin" EXACT [] +synonym: "clade B serpins" EXACT [] +synonym: "ov-serpins" EXACT [] +xref: BEL:"SERPINB Family" +xref: NEXTPROT-FAMILY:03579 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:3311 ! SERPINB1 +relationship: inverse_is_a HGNC:8584 ! SERPINB2 +relationship: inverse_is_a HGNC:10569 ! SERPINB3 +relationship: inverse_is_a HGNC:10570 ! SERPINB4 +relationship: inverse_is_a HGNC:8949 ! SERPINB5 +relationship: inverse_is_a HGNC:8950 ! SERPINB6 +relationship: inverse_is_a HGNC:13902 ! SERPINB7 +relationship: inverse_is_a HGNC:8952 ! SERPINB8 +relationship: inverse_is_a HGNC:8955 ! SERPINB9 +relationship: inverse_is_a HGNC:8942 ! SERPINB10 +relationship: inverse_is_a HGNC:14221 ! SERPINB11 +relationship: inverse_is_a HGNC:14220 ! SERPINB12 +relationship: inverse_is_a HGNC:8944 ! SERPINB13 + +[Term] +id: FPLX:000432 +name: SHC +synonym: "Shc family" EXACT [] +synonym: "SHC" EXACT [] +synonym: "Shc" EXACT [] +xref: IP:IPR006019 +xref: MEDSCAN:urn:agi-protfc:shc%20protein +xref: RE:R-HSA-167023 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:10840 ! SHC1 +relationship: inverse_is_a HGNC:29869 ! SHC2 +relationship: inverse_is_a HGNC:18181 ! SHC3 +relationship: inverse_is_a HGNC:16743 ! SHC4 + +[Term] +id: FPLX:000433 +name: SIK +synonym: "SIK" EXACT [] +synonym: "salt inducible kinase" EXACT [] +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:11142 ! SIK1 +relationship: inverse_is_a HGNC:21680 ! SIK2 +relationship: inverse_is_a HGNC:29165 ! SIK3 + +[Term] +id: FPLX:000434 +name: SLC2A +synonym: "glucose transporter" EXACT [] +synonym: "glucose transporters" EXACT [] +synonym: "GLUT" EXACT [] +synonym: "SLC2" EXACT [] +xref: BEL:"SLC2A Family" +xref: GO:0005355 +xref: NEXTPROT-FAMILY:02159 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:11005 ! SLC2A1 +relationship: inverse_is_a HGNC:11006 ! SLC2A2 +relationship: inverse_is_a HGNC:11007 ! SLC2A3 +relationship: inverse_is_a HGNC:11009 ! SLC2A4 +relationship: inverse_is_a HGNC:11010 ! SLC2A5 +relationship: inverse_is_a HGNC:11011 ! SLC2A6 +relationship: inverse_is_a HGNC:13445 ! SLC2A7 +relationship: inverse_is_a HGNC:13812 ! SLC2A8 +relationship: inverse_is_a HGNC:13446 ! SLC2A9 +relationship: inverse_is_a HGNC:13444 ! SLC2A10 +relationship: inverse_is_a HGNC:14239 ! SLC2A11 +relationship: inverse_is_a HGNC:18067 ! SLC2A12 +relationship: inverse_is_a HGNC:18301 ! SLC2A14 + +[Term] +id: FPLX:000435 +name: SLRP +synonym: "SLRP" EXACT [] +synonym: "SLRPs" EXACT [] +synonym: "SLRR" EXACT [] +synonym: "SLRRs" EXACT [] +synonym: "small leucine rich proteoglycan family" EXACT [] +synonym: "small leucine rich proteoglycan" EXACT [] +synonym: "small leucine rich proteoglycans" EXACT [] +synonym: "small leucine-rich proteoglycan family" EXACT [] +synonym: "small leucine-rich proteoglycan" EXACT [] +synonym: "small leucine-rich proteoglycans" EXACT [] +xref: NEXTPROT-FAMILY:03672 +xref: SIGNOR:SIGNOR-PF31 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a FPLX:000436 ! SLRP_1 +relationship: inverse_is_a FPLX:000437 ! SLRP_2 +relationship: inverse_is_a FPLX:000438 ! SLRP_3 +relationship: inverse_is_a FPLX:000439 ! SLRP_4 +relationship: inverse_is_a FPLX:000440 ! SLRP_5 + +[Term] +id: FPLX:000436 +name: SLRP-1 +xref: NEXTPROT-FAMILY:03673 +is_a: FPLX:000435 ! SLRP +relationship: inverse_is_a HGNC:1044 ! BGN +relationship: inverse_is_a HGNC:2705 ! DCN +relationship: inverse_is_a HGNC:14872 ! ASPN +relationship: inverse_is_a HGNC:3154 ! ECM2 + +[Term] +id: FPLX:000437 +name: SLRP-2 +xref: NEXTPROT-FAMILY:03674 +is_a: FPLX:000435 ! SLRP +relationship: inverse_is_a HGNC:3774 ! FMOD +relationship: inverse_is_a HGNC:6724 ! LUM +relationship: inverse_is_a HGNC:9357 ! PRELP +relationship: inverse_is_a HGNC:6309 ! KERA +relationship: inverse_is_a HGNC:8134 ! OMD + +[Term] +id: FPLX:000438 +name: SLRP-3 +xref: NEXTPROT-FAMILY:03675 +is_a: FPLX:000435 ! SLRP +relationship: inverse_is_a HGNC:3053 ! EPYC +relationship: inverse_is_a HGNC:8158 ! OPTC +relationship: inverse_is_a HGNC:8126 ! OGN + +[Term] +id: FPLX:000439 +name: SLRP-4 +xref: NEXTPROT-FAMILY:03676 +is_a: FPLX:000435 ! SLRP +relationship: inverse_is_a HGNC:1909 ! CHAD +relationship: inverse_is_a HGNC:8082 ! NYX +relationship: inverse_is_a HGNC:28850 ! TSKU + +[Term] +id: FPLX:000440 +name: SLRP-5 +xref: NEXTPROT-FAMILY:03677 +is_a: FPLX:000435 ! SLRP +relationship: inverse_is_a HGNC:23174 ! PODN +relationship: inverse_is_a HGNC:26275 ! PODNL1 + +[Term] +id: FPLX:000441 +name: SMAD +synonym: "SMAD" EXACT [] +synonym: "Smad" EXACT [] +synonym: "smad" EXACT [] +xref: BEL:"SMAD Family" +xref: IP:IPR001132 +xref: IP:IPR013019 +xref: IP:IPR013790 +xref: MEDSCAN:urn:agi-aopfc:0000159 +xref: MEDSCAN:urn:agi-complex:prophash-72ef5fc0ab431a39e0e2915bf55b6e28 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:6767 ! SMAD1 +relationship: inverse_is_a HGNC:6770 ! SMAD4 +relationship: inverse_is_a HGNC:6771 ! SMAD5 +relationship: inverse_is_a HGNC:6772 ! SMAD6 +relationship: inverse_is_a HGNC:6773 ! SMAD7 +relationship: inverse_is_a HGNC:6774 ! SMAD9 +relationship: inverse_is_a FPLX:000443 ! SMAD2_3 +relationship: inverse_is_a FPLX:000442 ! SMAD1_5_9 + +[Term] +id: FPLX:000442 +name: SMAD1-5-9 +xref: SIGNOR:SIGNOR-PF35 +is_a: FPLX:000441 ! SMAD +relationship: inverse_is_a HGNC:6767 ! SMAD1 +relationship: inverse_is_a HGNC:6771 ! SMAD5 +relationship: inverse_is_a HGNC:6774 ! SMAD9 + +[Term] +id: FPLX:000443 +name: SMAD2-3 +synonym: "SMAD 2/3" EXACT [] +synonym: "SMAD2/3" EXACT [] +synonym: "Smad2/3" EXACT [] +xref: MEDSCAN:urn:agi-complex:SMAD2%2f3 +xref: RE:R-HSA-171172 +xref: RE:R-HSA-171182 +xref: RE:R-HSA-177105 +xref: RE:R-HSA-2176482 +xref: RE:R-HSA-2187329 +xref: RE:R-HSA-2187387 +is_a: FPLX:000441 ! SMAD +relationship: inverse_is_a HGNC:6768 ! SMAD2 +relationship: inverse_is_a HGNC:6769 ! SMAD3 + +[Term] +id: FPLX:000444 +name: SMC1 +synonym: "SMC1" EXACT [] +synonym: "Smc1" EXACT [] +xref: BEL:"SMC1 Family" +xref: NEXTPROT-FAMILY:03686 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:11111 ! SMC1A +relationship: inverse_is_a HGNC:11112 ! SMC1B + +[Term] +id: FPLX:000445 +name: SMURF +xref: SIGNOR:SIGNOR-PF29 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:16807 ! SMURF1 +relationship: inverse_is_a HGNC:16809 ! SMURF2 + +[Term] +id: FPLX:000446 +name: SNAI +synonym: "SNAI family" EXACT [] +synonym: "SNAI" EXACT [] +xref: BEL:"SNAI Family" +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:11128 ! SNAI1 +relationship: inverse_is_a HGNC:11094 ! SNAI2 +relationship: inverse_is_a HGNC:18411 ! SNAI3 + +[Term] +id: FPLX:000447 +name: SOD +synonym: "SOD" EXACT [] +xref: BEL:"Cu-Zn SOD Family" +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:11179 ! SOD1 +relationship: inverse_is_a HGNC:11180 ! SOD2 +relationship: inverse_is_a HGNC:11181 ! SOD3 + +[Term] +id: FPLX:000448 +name: SOS +synonym: "SOS" EXACT [] +xref: BEL:"SOS Family" +xref: RE:R-HSA-167215 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:11187 ! SOS1 +relationship: inverse_is_a HGNC:11188 ! SOS2 + +[Term] +id: FPLX:000449 +name: SPRED +synonym: "SPRED" EXACT [] +xref: IP:IPR023337 +xref: RE:R-HSA-5658219 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:20249 ! SPRED1 +relationship: inverse_is_a HGNC:17722 ! SPRED2 +relationship: inverse_is_a HGNC:31041 ! SPRED3 + +[Term] +id: FPLX:000450 +name: SPRY +synonym: "SPRY" EXACT [] +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:11269 ! SPRY1 +relationship: inverse_is_a HGNC:11270 ! SPRY2 +relationship: inverse_is_a HGNC:11271 ! SPRY3 +relationship: inverse_is_a HGNC:15533 ! SPRY4 + +[Term] +id: FPLX:000451 +name: SRC +synonym: "SFK" EXACT [] +synonym: "Src family kinase" EXACT [] +synonym: "Src family" EXACT [] +synonym: "src kinases" EXACT [] +synonym: "SRC-family kinases" EXACT [] +synonym: "Src-kinases" EXACT [] +xref: BEL:"SRC Family" +xref: MEDSCAN:urn:agi-aopfc:0000509 +xref: NEXTPROT-FAMILY:03131 +xref: SIGNOR:SIGNOR-PF32 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:3697 ! FGR +relationship: inverse_is_a HGNC:4037 ! FYN +relationship: inverse_is_a HGNC:11283 ! SRC +relationship: inverse_is_a HGNC:12841 ! YES1 + +[Term] +id: FPLX:000452 +name: SREBF +synonym: "SREBF family" EXACT [] +synonym: "SREBF" EXACT [] +synonym: "sterol regulatory element binding protein" EXACT [] +synonym: "sterol regulatory element-binding factor" EXACT [] +xref: BEL:"SREBF Family" +xref: MEDSCAN:urn:agi-protfc:sterol%20regulatory%20element%20binding%20protein +xref: RE:R-HSA-1655720 +xref: RE:R-HSA-1655725 +xref: RE:R-HSA-1655726 +xref: RE:R-HSA-1655730 +xref: RE:R-HSA-1655732 +xref: RE:R-HSA-1655734 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:11289 ! SREBF1 +relationship: inverse_is_a HGNC:11290 ! SREBF2 + +[Term] +id: FPLX:000453 +name: STAT +synonym: "STAT" EXACT [] +synonym: "STATs" EXACT [] +xref: BEL:"STAT Family" +xref: IP:IPR001217 +xref: IP:IPR012345 +xref: IP:IPR013799 +xref: IP:IPR013800 +xref: IP:IPR013801 +xref: IP:IPR015988 +xref: MEDSCAN:urn:agi-aopfc:0000163 +xref: MEDSCAN:urn:agi-complex:prophash-2de597c3f4a807f3caeaf02e5f93ce15 +xref: NCIT:C19618 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:11362 ! STAT1 +relationship: inverse_is_a HGNC:11363 ! STAT2 +relationship: inverse_is_a HGNC:11364 ! STAT3 +relationship: inverse_is_a HGNC:11365 ! STAT4 +relationship: inverse_is_a HGNC:11368 ! STAT6 +relationship: inverse_is_a FPLX:000454 ! STAT5 + +[Term] +id: FPLX:000454 +name: STAT5 +synonym: "STAT5" EXACT [] +synonym: "Stat5" EXACT [] +xref: BEL:"STAT5 Family" +xref: MEDSCAN:urn:agi-protfc:STAT5%20protein +xref: RE:R-HSA-1469978 +xref: RE:R-HSA-452094 +xref: RE:R-HSA-507919 +xref: RE:R-HSA-507929 +xref: RE:R-HSA-508012 +xref: RE:R-HSA-8865622 +is_a: FPLX:000453 ! STAT +relationship: inverse_is_a HGNC:11366 ! STAT5A +relationship: inverse_is_a HGNC:11367 ! STAT5B + +[Term] +id: FPLX:000455 +name: STT3 +synonym: "STT3" EXACT [] +is_a: FPLX:000198 ! Glycosyltransferase +relationship: inverse_is_a HGNC:6172 ! STT3A +relationship: inverse_is_a HGNC:30611 ! STT3B + +[Term] +id: FPLX:000456 +name: Sulfonylurea-receptor +synonym: "Sulfonylurea Receptor" EXACT [] +synonym: "sulfonylurea receptor" EXACT [] +synonym: "sulfonylurea receptors" EXACT [] +synonym: "SUR" EXACT [] +xref: BEL:"Sulfonylurea Receptor Family" +xref: GO:0008281 +xref: IP:IPR000388 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:59 ! ABCC8 +relationship: inverse_is_a HGNC:60 ! ABCC9 + +[Term] +id: FPLX:000457 +name: SWI-SNF +synonym: "SWI and SNF complex" EXACT [] +synonym: "SWI/SNF complex" EXACT [] +synonym: "SWI/SNF" EXACT [] +synonym: "SWI/SNF-like" EXACT [] +xref: BEL:"SWI/SNF Complex" +xref: MEDSCAN:urn:agi-complex:prophash-f7a9dc05e48afd7a93466cfbd5504861 +xref: MEDSCAN:urn:agi-protfc:chromatin%20remodeling%20complex +xref: MEDSCAN:urn:agi-protfc:SWI%2fSNF%20family +xref: NCIT:C20591 +is_a: FPLX:000000 ! famplex +relationship: has_part HGNC:11110 ! ARID1A +relationship: has_part HGNC:18040 ! ARID1B +relationship: has_part HGNC:11097 ! SMARCA1 +relationship: has_part HGNC:11098 ! SMARCA2 +relationship: has_part HGNC:11100 ! SMARCA4 +relationship: has_part HGNC:11101 ! SMARCA5 +relationship: has_part HGNC:11103 ! SMARCB1 +relationship: has_part HGNC:11104 ! SMARCC1 +relationship: has_part HGNC:11105 ! SMARCC2 +relationship: has_part HGNC:11106 ! SMARCD1 +relationship: has_part HGNC:11107 ! SMARCD2 +relationship: has_part HGNC:11108 ! SMARCD3 +relationship: has_part HGNC:11109 ! SMARCE1 +relationship: has_part HGNC:24124 ! ACTL6A +relationship: has_part HGNC:160 ! ACTL6B +relationship: has_part HGNC:11099 ! HLTF + +[Term] +id: FPLX:000458 +name: TAOK +xref: SIGNOR:SIGNOR-PF21 +is_a: FPLX:000282 ! MAP3K +relationship: inverse_is_a HGNC:29259 ! TAOK1 +relationship: inverse_is_a HGNC:16835 ! TAOK2 +relationship: inverse_is_a HGNC:18133 ! TAOK3 + +[Term] +id: FPLX:000459 +name: TAP +synonym: "TAP transporter" EXACT [] +synonym: "TAP" EXACT [] +xref: BEL:"TAP Family" +xref: GO:0042825 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:43 ! TAP1 +relationship: inverse_is_a HGNC:44 ! TAP2 +relationship: inverse_is_a HGNC:50 ! ABCB9 + +[Term] +id: FPLX:000460 +name: TCF-LEF +synonym: "T-cell factor (TCF)/lymphoid enhancer factor" EXACT [] +synonym: "TCF" EXACT [] +synonym: "Tcf" EXACT [] +synonym: "Tcf/Lef" EXACT [] +xref: BEL:"TCF/LEF Family" +xref: IP:IPR013558 +xref: IP:IPR024940 +xref: NEXTPROT-FAMILY:03943 +xref: RE:R-HSA-3299546 +xref: RE:R-HSA-5323539 +xref: RE:R-HSA-8944354 +xref: RE:R-HSA-8951427 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:6551 ! LEF1 +relationship: inverse_is_a HGNC:11639 ! TCF7 +relationship: inverse_is_a HGNC:11640 ! TCF7L1 +relationship: inverse_is_a HGNC:11641 ! TCF7L2 + +[Term] +id: FPLX:000461 +name: TCR +synonym: "TCR" EXACT [] +xref: MESH:D011948 +xref: NCIT:C17065 +is_a: FPLX:000000 ! famplex +relationship: has_part HGNC:12027 ! TRA +relationship: has_part HGNC:12155 ! TRB +relationship: has_part HGNC:12252 ! TRD +relationship: has_part HGNC:12271 ! TRG + +[Term] +id: FPLX:000462 +name: TEAD +xref: SIGNOR:SIGNOR-PF22 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:11714 ! TEAD1 +relationship: inverse_is_a HGNC:11715 ! TEAD2 +relationship: inverse_is_a HGNC:11716 ! TEAD3 +relationship: inverse_is_a HGNC:11717 ! TEAD4 + +[Term] +id: FPLX:000463 +name: TFAP2 +synonym: "AP-2 transcription factor" EXACT [] +synonym: "Transcription factor AP-2" EXACT [] +synonym: "transcription factor AP-2" EXACT [] +xref: BEL:"TFAP2 Family" +xref: IP:IPR004979 +xref: IP:IPR013854 +xref: NEXTPROT-FAMILY:00209 +xref: RE:R-HSA-8864283 +xref: RE:R-HSA-8864286 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:11742 ! TFAP2A +relationship: inverse_is_a HGNC:11743 ! TFAP2B +relationship: inverse_is_a HGNC:11744 ! TFAP2C +relationship: inverse_is_a HGNC:15581 ! TFAP2D +relationship: inverse_is_a HGNC:30774 ! TFAP2E + +[Term] +id: FPLX:000464 +name: TFDP +synonym: "DP complex" EXACT [] +synonym: "TFDP" EXACT [] +synonym: "transcription factor DP" EXACT [] +xref: BEL:"TFDP Family" +xref: RE:R-HSA-1362227 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:11749 ! TFDP1 +relationship: inverse_is_a HGNC:11751 ! TFDP2 + +[Term] +id: FPLX:000465 +name: TGFB +synonym: "TGF beta" EXACT [] +synonym: "TGF β" EXACT [] +synonym: "TGF-b" EXACT [] +synonym: "TGF-beta family" EXACT [] +synonym: "TGF-beta" EXACT [] +synonym: "TGF-β" EXACT [] +synonym: "TGFB family" EXACT [] +synonym: "TGFB" EXACT [] +synonym: "TGFbeta" EXACT [] +synonym: "TGFβ" EXACT [] +synonym: "transforming growth factor beta" EXACT [] +synonym: "transforming growth factor β" EXACT [] +synonym: "transforming growth factor-beta" EXACT [] +synonym: "transforming growth factor-β" EXACT [] +xref: BEL:"TGFB Family" +xref: IP:IPR015615 +xref: IP:IPR016319 +xref: MEDSCAN:urn:agi-aopfc:0000423 +xref: NEXTPROT-FAMILY:03989 +xref: RE:R-HSA-114657 +xref: RE:R-HSA-2395330 +xref: SIGNOR:SIGNOR-PF5 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:11766 ! TGFB1 +relationship: inverse_is_a HGNC:11768 ! TGFB2 +relationship: inverse_is_a HGNC:11769 ! TGFB3 + +[Term] +id: FPLX:000466 +name: TGFBR +synonym: "TGF beta receptor" EXACT [] +synonym: "TGF β receptor" EXACT [] +synonym: "TGF-beta receptor" EXACT [] +synonym: "TGF-beta receptors" EXACT [] +synonym: "TGF-β receptor" EXACT [] +synonym: "TGF-β receptors" EXACT [] +synonym: "TGFBR family" EXACT [] +synonym: "TGFBR" EXACT [] +synonym: "TGFβ receptor" EXACT [] +synonym: "TGFβ receptors" EXACT [] +xref: MEDSCAN:urn:agi-aopfc:0000294 +xref: MEDSCAN:urn:agi-complex:prophash-9e456bf1de2c5eb1107156c96a1450e6 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:11772 ! TGFBR1 +relationship: inverse_is_a HGNC:11773 ! TGFBR2 +relationship: inverse_is_a HGNC:11774 ! TGFBR3 + +[Term] +id: FPLX:000467 +name: THBS +synonym: "thrombospondin protein" EXACT [] +synonym: "Thrombospondin" EXACT [] +synonym: "thrombospondin" EXACT [] +synonym: "Thrombospondins" EXACT [] +synonym: "thrombospondins" EXACT [] +xref: BEL:"THBS Family" +xref: IP:IPR003367 +xref: IP:IPR008859 +xref: IP:IPR017897 +xref: IP:IPR028974 +xref: MEDSCAN:urn:agi-protfc:thrombospondins +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:11785 ! THBS1 +relationship: inverse_is_a HGNC:11786 ! THBS2 +relationship: inverse_is_a HGNC:11787 ! THBS3 +relationship: inverse_is_a HGNC:11788 ! THBS4 +relationship: inverse_is_a HGNC:2227 ! COMP + +[Term] +id: FPLX:000468 +name: THR +synonym: "thyroid hormone receptor" EXACT [] +xref: BEL:"THR Family" +xref: NCIT:C17078 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:11796 ! THRA +relationship: inverse_is_a HGNC:11799 ! THRB + +[Term] +id: FPLX:000469 +name: Thrombin-antithrombin +synonym: "thrombin-anti-thrombin III complexes" EXACT [] +xref: BEL:"Thrombin Antithrombin Complex" +xref: RE:R-HSA-140812 +xref: RE:R-HSA-140871 +xref: RE:R-HSA-140874 +is_a: FPLX:000000 ! famplex +relationship: has_part HGNC:3535 ! F2 +relationship: has_part HGNC:775 ! SERPINC1 + +[Term] +id: FPLX:000470 +name: TIAM +synonym: "TIAM" EXACT [] +xref: NEXTPROT-FAMILY:04014 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:11805 ! TIAM1 +relationship: inverse_is_a HGNC:11806 ! TIAM2 + +[Term] +id: FPLX:000471 +name: TIF-IB +synonym: "TIF-IB" EXACT [] +xref: BEL:"TIF IB Complex" +is_a: FPLX:000000 ! famplex +relationship: has_part HGNC:11532 ! TAF1A +relationship: has_part HGNC:11533 ! TAF1B +relationship: has_part HGNC:11534 ! TAF1C +relationship: has_part HGNC:11588 ! TBP + +[Term] +id: FPLX:000472 +name: TLR +synonym: "TLR" EXACT [] +xref: MEDSCAN:urn:agi-aopfc:0000296 +xref: SIGNOR:SIGNOR-PF20 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:11847 ! TLR1 +relationship: inverse_is_a HGNC:11848 ! TLR2 +relationship: inverse_is_a HGNC:11849 ! TLR3 +relationship: inverse_is_a HGNC:11850 ! TLR4 +relationship: inverse_is_a HGNC:11851 ! TLR5 +relationship: inverse_is_a HGNC:16711 ! TLR6 +relationship: inverse_is_a HGNC:15631 ! TLR7 +relationship: inverse_is_a HGNC:15632 ! TLR8 +relationship: inverse_is_a HGNC:15633 ! TLR9 +relationship: inverse_is_a HGNC:15634 ! TLR10 + +[Term] +id: FPLX:000473 +name: TN +synonym: "Tenascin" EXACT [] +synonym: "tenascin" EXACT [] +xref: BEL:"TN Family" +xref: NCIT:C104676 +xref: NEXTPROT-FAMILY:03964 +xref: RE:R-HSA-2672035 +xref: RE:R-HSA-2681744 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:5318 ! TNC +relationship: inverse_is_a HGNC:22942 ! TNN +relationship: inverse_is_a HGNC:11953 ! TNR +relationship: inverse_is_a HGNC:11976 ! TNXB + +[Term] +id: FPLX:000474 +name: TNF +xref: NEXTPROT-FAMILY:04243 +xref: XFAM:PF00229 +is_a: FPLX:000000 ! famplex + +[Term] +id: FPLX:000475 +name: TNFRSF +synonym: "TNF-R superfamily" EXACT [] +synonym: "TNF-receptor family" EXACT [] +synonym: "TNFR family" EXACT [] +synonym: "TNFR subfamily" EXACT [] +synonym: "TNFR superfamily members" EXACT [] +synonym: "TNFR superfamily receptors" EXACT [] +synonym: "TNFR superfamily" EXACT [] +synonym: "TNFR" EXACT [] +xref: BEL:"TNFRSF Family" +xref: MEDSCAN:urn:agi-aopfc:0000295 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:11916 ! TNFRSF1A +relationship: inverse_is_a HGNC:11917 ! TNFRSF1B +relationship: inverse_is_a HGNC:11918 ! TNFRSF4 +relationship: inverse_is_a HGNC:11923 ! TNFRSF8 +relationship: inverse_is_a HGNC:11924 ! TNFRSF9 +relationship: inverse_is_a HGNC:11904 ! TNFRSF10A +relationship: inverse_is_a HGNC:11905 ! TNFRSF10B +relationship: inverse_is_a HGNC:11906 ! TNFRSF10C +relationship: inverse_is_a HGNC:11907 ! TNFRSF10D +relationship: inverse_is_a HGNC:11908 ! TNFRSF11A +relationship: inverse_is_a HGNC:11909 ! TNFRSF11B +relationship: inverse_is_a HGNC:18152 ! TNFRSF12A +relationship: inverse_is_a HGNC:18153 ! TNFRSF13B +relationship: inverse_is_a HGNC:17755 ! TNFRSF13C +relationship: inverse_is_a HGNC:11912 ! TNFRSF14 +relationship: inverse_is_a HGNC:11913 ! TNFRSF17 +relationship: inverse_is_a HGNC:11914 ! TNFRSF18 +relationship: inverse_is_a HGNC:11915 ! TNFRSF19 +relationship: inverse_is_a HGNC:13469 ! TNFRSF21 +relationship: inverse_is_a HGNC:11910 ! TNFRSF25 + +[Term] +id: FPLX:000476 +name: TOP2 +synonym: "topoisomerase II" EXACT [] +xref: BEL:"TOP2 Family" +xref: IP:IPR001154 +xref: IP:IPR001241 +xref: IP:IPR002205 +xref: IP:IPR012542 +xref: IP:IPR013506 +xref: IP:IPR013757 +xref: IP:IPR013758 +xref: IP:IPR013759 +xref: IP:IPR013760 +xref: IP:IPR018522 +xref: IP:IPR024946 +xref: IP:IPR031660 +xref: IP:IPR034157 +xref: NCIT:C18434 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:11989 ! TOP2A +relationship: inverse_is_a HGNC:11990 ! TOP2B + +[Term] +id: FPLX:000477 +name: Troponin +synonym: "troponin complex" EXACT [] +synonym: "troponin" EXACT [] +synonym: "troponins" EXACT [] +xref: GO:0005861 +xref: MEDSCAN:urn:agi-complex:prophash-e4ec238e69c3d3292966ac97dbc11086 +xref: RE:R-HSA-390583 +xref: RE:R-HSA-390585 +is_a: FPLX:000000 ! famplex +relationship: has_part FPLX:000478 ! Troponin_C +relationship: has_part FPLX:000479 ! Troponin_I +relationship: has_part FPLX:000480 ! Troponin_T + +[Term] +id: FPLX:000478 +name: Troponin-C +synonym: "cTnC" EXACT [] +synonym: "cTnI" EXACT [] +synonym: "TN-C" EXACT [] +synonym: "TnC" EXACT [] +synonym: "troponin C" EXACT [] +xref: RE:R-HSA-390532 +xref: RE:R-HSA-390587 +relationship: part_of FPLX:000477 ! Troponin +relationship: inverse_is_a HGNC:11943 ! TNNC1 +relationship: inverse_is_a HGNC:11944 ! TNNC2 + +[Term] +id: FPLX:000479 +name: Troponin-I +synonym: "TPNI" EXACT [] +synonym: "troponin I" EXACT [] +xref: NCIT:C17343 +xref: RE:R-HSA-390541 +relationship: part_of FPLX:000477 ! Troponin +relationship: inverse_is_a HGNC:11945 ! TNNI1 +relationship: inverse_is_a HGNC:11946 ! TNNI2 +relationship: inverse_is_a HGNC:11947 ! TNNI3 + +[Term] +id: FPLX:000480 +name: Troponin-T +synonym: "cTnT" EXACT [] +synonym: "TPNT" EXACT [] +synonym: "troponin T" EXACT [] +xref: IP:IPR027707 +xref: NCIT:C38041 +xref: RE:R-HSA-390546 +relationship: part_of FPLX:000477 ! Troponin +relationship: inverse_is_a HGNC:11948 ! TNNT1 +relationship: inverse_is_a HGNC:11949 ! TNNT2 +relationship: inverse_is_a HGNC:11950 ! TNNT3 + +[Term] +id: FPLX:000481 +name: Tryptase +synonym: "Tryptase" EXACT [] +synonym: "tryptase" EXACT [] +synonym: "tryptases" EXACT [] +xref: BEL:"Tryptase Family" +xref: ECCODE:3.4.21.59 +xref: NCIT:C120030 +xref: NEXTPROT-FAMILY:02767 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:12019 ! TPSAB1 +relationship: inverse_is_a HGNC:14120 ! TPSB2 +relationship: inverse_is_a HGNC:14118 ! TPSD1 +relationship: inverse_is_a HGNC:14134 ! TPSG1 + +[Term] +id: FPLX:000482 +name: TSC +synonym: "TSC" EXACT [] +xref: RE:R-HSA-165175 +xref: RE:R-HSA-165180 +xref: RE:R-HSA-381855 +xref: RE:R-HSA-5672337 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:12362 ! TSC1 +relationship: inverse_is_a HGNC:12363 ! TSC2 + +[Term] +id: FPLX:000483 +name: TUBA +synonym: "alpha tubulin" EXACT [] +synonym: "TUBA" EXACT [] +synonym: "tubulin alpha chain" EXACT [] +synonym: "tubulin α chain" EXACT [] +synonym: "α tubulin" EXACT [] +xref: BEL:"TUBA Family" +is_a: FPLX:000486 ! Tubulin +relationship: inverse_is_a HGNC:20766 ! TUBA1A +relationship: inverse_is_a HGNC:18809 ! TUBA1B +relationship: inverse_is_a HGNC:20768 ! TUBA1C +relationship: inverse_is_a HGNC:12408 ! TUBA3C +relationship: inverse_is_a HGNC:24071 ! TUBA3D +relationship: inverse_is_a HGNC:20765 ! TUBA3E +relationship: inverse_is_a HGNC:12407 ! TUBA4A +relationship: inverse_is_a HGNC:12410 ! TUBA8 +relationship: inverse_is_a HGNC:23534 ! TUBAL3 + +[Term] +id: FPLX:000484 +name: TUBB +synonym: "Beta Tubulin" EXACT [] +synonym: "Beta tubulin" EXACT [] +synonym: "beta Tubulin" EXACT [] +synonym: "beta tubulin" EXACT [] +synonym: "Beta-Tubulin" EXACT [] +synonym: "Beta-tubulin" EXACT [] +synonym: "beta-Tubulin" EXACT [] +synonym: "beta-tubulin" EXACT [] +synonym: "TUBB" EXACT [] +synonym: "tubulin beta chain" EXACT [] +synonym: "tubulin beta" EXACT [] +synonym: "tubulin β chain" EXACT [] +synonym: "tubulin β" EXACT [] +xref: BEL:"TUBB Family" +xref: IP:IPR002453 +xref: NCIT:C129655 +is_a: FPLX:000486 ! Tubulin +relationship: inverse_is_a HGNC:20778 ! TUBB +relationship: inverse_is_a HGNC:16257 ! TUBB1 +relationship: inverse_is_a HGNC:12412 ! TUBB2A +relationship: inverse_is_a HGNC:30829 ! TUBB2B +relationship: inverse_is_a HGNC:20772 ! TUBB3 +relationship: inverse_is_a HGNC:20774 ! TUBB4A +relationship: inverse_is_a HGNC:20771 ! TUBB4B +relationship: inverse_is_a HGNC:20776 ! TUBB6 + +[Term] +id: FPLX:000485 +name: TUBG +synonym: "Gamma tubulin" EXACT [] +synonym: "gamma tubulin" EXACT [] +synonym: "gamma-tubulin" EXACT [] +synonym: "tubulin gamma" EXACT [] +synonym: "tubulin γ" EXACT [] +synonym: "γ tubulin" EXACT [] +synonym: "γ-tubulin" EXACT [] +xref: GO:0000930 +xref: IP:IPR002454 +is_a: FPLX:000486 ! Tubulin +relationship: inverse_is_a HGNC:12417 ! TUBG1 +relationship: inverse_is_a HGNC:12419 ! TUBG2 + +[Term] +id: FPLX:000486 +name: Tubulin +synonym: "tubulin" EXACT [] +xref: MEDSCAN:urn:agi-complex:prophash-90a087d4e73b3992c65edfd9f71c6802 +xref: MEDSCAN:urn:agi-protfc:tubulin +xref: NCIT:C17219 +xref: NEXTPROT-FAMILY:04239 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a FPLX:000483 ! TUBA +relationship: inverse_is_a FPLX:000484 ! TUBB +relationship: inverse_is_a FPLX:000485 ! TUBG +relationship: inverse_is_a HGNC:16811 ! TUBD1 +relationship: inverse_is_a HGNC:20775 ! TUBE1 + +[Term] +id: FPLX:000487 +name: TXN +synonym: "Thioredoxin" EXACT [] +synonym: "thioredoxin" EXACT [] +synonym: "thioredoxins" EXACT [] +xref: BEL:"TXN Family" +xref: MEDSCAN:urn:agi-protfc:thioredoxin +xref: NEXTPROT-FAMILY:04000 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:12435 ! TXN +relationship: inverse_is_a HGNC:17772 ! TXN2 + +[Term] +id: FPLX:000488 +name: TXNRD +synonym: "Thioredoxin reductase" EXACT [] +synonym: "thioredoxin reductase" EXACT [] +xref: BEL:"TXNRD Family" +xref: IP:IPR006338 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:12437 ! TXNRD1 +relationship: inverse_is_a HGNC:18155 ! TXNRD2 +relationship: inverse_is_a HGNC:20667 ! TXNRD3 + +[Term] +id: FPLX:000489 +name: UBE2 +synonym: "E2 enzyme" EXACT [] +synonym: "E2 ubiquitin-conjugating enzyme" EXACT [] +synonym: "E2" EXACT [] +synonym: "UBE2" EXACT [] +synonym: "ubiquitin conjugating enzyme" EXACT [] +synonym: "ubiquitin-conjugating enzymes" EXACT [] +xref: BEL:"UBE2 Family" +xref: ECCODE:2.3.2.23 +xref: GO:0019787 +xref: NEXTPROT-FAMILY:04282 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:1734 ! CDC34 +relationship: inverse_is_a HGNC:12472 ! UBE2A +relationship: inverse_is_a HGNC:12473 ! UBE2B +relationship: inverse_is_a HGNC:15937 ! UBE2C +relationship: inverse_is_a HGNC:12474 ! UBE2D1 +relationship: inverse_is_a HGNC:12475 ! UBE2D2 +relationship: inverse_is_a HGNC:12476 ! UBE2D3 +relationship: inverse_is_a HGNC:21647 ! UBE2D4 +relationship: inverse_is_a HGNC:12477 ! UBE2E1 +relationship: inverse_is_a HGNC:12478 ! UBE2E2 +relationship: inverse_is_a HGNC:12479 ! UBE2E3 +relationship: inverse_is_a HGNC:12480 ! UBE2F +relationship: inverse_is_a HGNC:12482 ! UBE2G1 +relationship: inverse_is_a HGNC:12483 ! UBE2G2 +relationship: inverse_is_a HGNC:12484 ! UBE2H +relationship: inverse_is_a HGNC:12485 ! UBE2I +relationship: inverse_is_a HGNC:17598 ! UBE2J1 +relationship: inverse_is_a HGNC:19268 ! UBE2J2 +relationship: inverse_is_a HGNC:12488 ! UBE2L3 +relationship: inverse_is_a HGNC:12490 ! UBE2L6 +relationship: inverse_is_a HGNC:12491 ! UBE2M +relationship: inverse_is_a HGNC:12492 ! UBE2N +relationship: inverse_is_a HGNC:31710 ! UBE2NL +relationship: inverse_is_a HGNC:15698 ! UBE2Q1 +relationship: inverse_is_a HGNC:19907 ! UBE2R2 +relationship: inverse_is_a HGNC:17895 ! UBE2S +relationship: inverse_is_a HGNC:12494 ! UBE2V1 +relationship: inverse_is_a HGNC:12495 ! UBE2V2 +relationship: inverse_is_a HGNC:25616 ! UBE2W + +[Term] +id: FPLX:000490 +name: Ubiquitin +synonym: "Ub" EXACT [] +synonym: "ub" EXACT [] +synonym: "Ubiquitin" EXACT [] +synonym: "ubiquitin" EXACT [] +xref: MEDSCAN:urn:agi-complex:prophash-50bd08479c3770278693a51fe379babd +xref: MEDSCAN:urn:agi-protfc:ubiquitin +xref: NCIT:C17227 +xref: NEXTPROT-FAMILY:04276 +is_a: FPLX:000000 ! famplex + +[Term] +id: FPLX:000491 +name: UGCG +is_a: FPLX:000198 ! Glycosyltransferase +relationship: inverse_is_a HGNC:12524 ! UGCG + +[Term] +id: FPLX:000492 +name: UGT +synonym: "UGT" EXACT [] +is_a: FPLX:000198 ! Glycosyltransferase +relationship: inverse_is_a HGNC:12529 ! UGT1A +relationship: inverse_is_a HGNC:12530 ! UGT1A1 +relationship: inverse_is_a HGNC:12534 ! UGT1A2P +relationship: inverse_is_a HGNC:12535 ! UGT1A3 +relationship: inverse_is_a HGNC:12536 ! UGT1A4 +relationship: inverse_is_a HGNC:12537 ! UGT1A5 +relationship: inverse_is_a HGNC:12538 ! UGT1A6 +relationship: inverse_is_a HGNC:12539 ! UGT1A7 +relationship: inverse_is_a HGNC:12540 ! UGT1A8 +relationship: inverse_is_a HGNC:12541 ! UGT1A9 +relationship: inverse_is_a HGNC:12531 ! UGT1A10 +relationship: inverse_is_a HGNC:12532 ! UGT1A11P +relationship: inverse_is_a HGNC:12533 ! UGT1A12P +relationship: inverse_is_a HGNC:32191 ! UGT1A13P +relationship: inverse_is_a HGNC:12542 ! UGT2A1 +relationship: inverse_is_a HGNC:28183 ! UGT2A2 +relationship: inverse_is_a HGNC:28528 ! UGT2A3 +relationship: inverse_is_a HGNC:12553 ! UGT2B4 +relationship: inverse_is_a HGNC:12554 ! UGT2B7 +relationship: inverse_is_a HGNC:12544 ! UGT2B10 +relationship: inverse_is_a HGNC:12545 ! UGT2B11 +relationship: inverse_is_a HGNC:12546 ! UGT2B15 +relationship: inverse_is_a HGNC:12547 ! UGT2B17 +relationship: inverse_is_a HGNC:12548 ! UGT2B24P +relationship: inverse_is_a HGNC:12549 ! UGT2B25P +relationship: inverse_is_a HGNC:12550 ! UGT2B26P +relationship: inverse_is_a HGNC:12551 ! UGT2B27P +relationship: inverse_is_a HGNC:13479 ! UGT2B28 +relationship: inverse_is_a HGNC:12552 ! UGT2B29P +relationship: inverse_is_a HGNC:26625 ! UGT3A1 +relationship: inverse_is_a HGNC:27266 ! UGT3A2 +relationship: inverse_is_a HGNC:12555 ! UGT8 + +[Term] +id: FPLX:000493 +name: UGGT +is_a: FPLX:000198 ! Glycosyltransferase +relationship: inverse_is_a HGNC:15663 ! UGGT1 +relationship: inverse_is_a HGNC:15664 ! UGGT2 + +[Term] +id: FPLX:000494 +name: VAV +synonym: "VAV family" EXACT [] +synonym: "Vav" EXACT [] +xref: BEL:"VAV Family" +xref: MEDSCAN:urn:agi-aopfc:0000504 +xref: RE:R-HSA-2029115 +xref: RE:R-HSA-430172 +xref: RE:R-HSA-434632 +xref: RE:R-HSA-442272 +xref: RE:R-HSA-442295 +xref: RE:R-HSA-5218789 +xref: RE:R-HSA-5340329 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:12657 ! VAV1 +relationship: inverse_is_a HGNC:12658 ! VAV2 +relationship: inverse_is_a HGNC:12659 ! VAV3 + +[Term] +id: FPLX:000495 +name: VEGF +synonym: "vascular endothelial growth factor" EXACT [] +synonym: "VEGF" EXACT [] +xref: BEL:"VEGF Family" +xref: NCIT:C129646 +xref: RE:R-HSA-195361 +xref: RE:R-HSA-195376 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:12680 ! VEGFA +relationship: inverse_is_a HGNC:12681 ! VEGFB +relationship: inverse_is_a HGNC:12682 ! VEGFC +relationship: inverse_is_a HGNC:3708 ! VEGFD +relationship: inverse_is_a HGNC:8893 ! PGF + +[Term] +id: FPLX:000496 +name: VEGFR +synonym: "VEGF receptor" EXACT [] +synonym: "VEGF receptors" EXACT [] +synonym: "VEGFR ligand" EXACT [] +synonym: "VEGFR" EXACT [] +synonym: "VEGFRs" EXACT [] +xref: BEL:"VEGFR Family" +xref: GO:0005172 +xref: NCIT:C17293 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:3763 ! FLT1 +relationship: inverse_is_a HGNC:3767 ! FLT4 +relationship: inverse_is_a HGNC:6307 ! KDR + +[Term] +id: FPLX:000497 +name: Wnt +synonym: "WNT" EXACT [] +synonym: "Wnt" EXACT [] +xref: BEL:"WNT Family" +xref: IP:IPR005817 +xref: IP:IPR018161 +xref: MEDSCAN:urn:agi-aopfc:0000426 +xref: NEXTPROT-FAMILY:04686 +xref: XFAM:PF00110 +xref: RE:R-HSA-3238268 +xref: RE:R-HSA-3238374 +xref: RE:R-HSA-3247790 +xref: RE:R-HSA-3247824 +xref: RE:R-HSA-3247835 +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:12774 ! WNT1 +relationship: inverse_is_a HGNC:12780 ! WNT2 +relationship: inverse_is_a HGNC:12781 ! WNT2B +relationship: inverse_is_a HGNC:12782 ! WNT3 +relationship: inverse_is_a HGNC:15983 ! WNT3A +relationship: inverse_is_a HGNC:12783 ! WNT4 +relationship: inverse_is_a HGNC:12784 ! WNT5A +relationship: inverse_is_a HGNC:16265 ! WNT5B +relationship: inverse_is_a HGNC:12785 ! WNT6 +relationship: inverse_is_a HGNC:12786 ! WNT7A +relationship: inverse_is_a HGNC:12787 ! WNT7B +relationship: inverse_is_a HGNC:12788 ! WNT8A +relationship: inverse_is_a HGNC:12789 ! WNT8B +relationship: inverse_is_a HGNC:12778 ! WNT9A +relationship: inverse_is_a HGNC:12779 ! WNT9B +relationship: inverse_is_a HGNC:13829 ! WNT10A +relationship: inverse_is_a HGNC:12775 ! WNT10B +relationship: inverse_is_a HGNC:12776 ! WNT11 +relationship: inverse_is_a HGNC:16267 ! WNT16 + +[Term] +id: FPLX:000498 +name: YBX +synonym: "Y box binding protein" EXACT [] +synonym: "Y-box-binding protein" EXACT [] +synonym: "YBX protein family" EXACT [] +is_a: FPLX:000000 ! famplex +relationship: inverse_is_a HGNC:8014 ! YBX1 +relationship: inverse_is_a HGNC:17948 ! YBX2 +relationship: inverse_is_a HGNC:2428 ! YBX3 + +[Term] +id: FPLX:000499 +name: ETC-complex-I-core +xref: HGNC_GROUP:1149 +relationship: part_of FPLX:000501 ! ETC_complex_I +relationship: has_part HGNC:7455 ! MT-ND1 +relationship: has_part HGNC:7456 ! MT-ND2 +relationship: has_part HGNC:7458 ! MT-ND3 +relationship: has_part HGNC:7459 ! MT-ND4 +relationship: has_part HGNC:7460 ! MT-ND4L +relationship: has_part HGNC:7461 ! MT-ND5 +relationship: has_part HGNC:7462 ! MT-ND6 +relationship: has_part HGNC:7707 ! NDUFS1 +relationship: has_part HGNC:7708 ! NDUFS2 +relationship: has_part HGNC:7710 ! NDUFS3 +relationship: has_part HGNC:7714 ! NDUFS7 +relationship: has_part HGNC:7715 ! NDUFS8 +relationship: has_part HGNC:7716 ! NDUFV1 +relationship: has_part HGNC:7717 ! NDUFV2 + +[Term] +id: FPLX:000500 +name: ETC-complex-I-supernumerary +xref: HGNC_GROUP:1150 +relationship: part_of FPLX:000501 ! ETC_complex_I +relationship: has_part HGNC:7694 ! NDUFAB1 +relationship: has_part HGNC:7683 ! NDUFA1 +relationship: has_part HGNC:7685 ! NDUFA2 +relationship: has_part HGNC:7686 ! NDUFA3 +relationship: has_part HGNC:7688 ! NDUFA5 +relationship: has_part HGNC:7690 ! NDUFA6 +relationship: has_part HGNC:7691 ! NDUFA7 +relationship: has_part HGNC:7692 ! NDUFA8 +relationship: has_part HGNC:7693 ! NDUFA9 +relationship: has_part HGNC:7684 ! NDUFA10 +relationship: has_part HGNC:20371 ! NDUFA11 +relationship: has_part HGNC:23987 ! NDUFA12 +relationship: has_part HGNC:17194 ! NDUFA13 +relationship: has_part HGNC:7695 ! NDUFB1 +relationship: has_part HGNC:7697 ! NDUFB2 +relationship: has_part HGNC:7698 ! NDUFB3 +relationship: has_part HGNC:7699 ! NDUFB4 +relationship: has_part HGNC:7700 ! NDUFB5 +relationship: has_part HGNC:7701 ! NDUFB6 +relationship: has_part HGNC:7702 ! NDUFB7 +relationship: has_part HGNC:7703 ! NDUFB8 +relationship: has_part HGNC:7704 ! NDUFB9 +relationship: has_part HGNC:7696 ! NDUFB10 +relationship: has_part HGNC:20372 ! NDUFB11 +relationship: has_part HGNC:7705 ! NDUFC1 +relationship: has_part HGNC:7706 ! NDUFC2 +relationship: has_part HGNC:7711 ! NDUFS4 +relationship: has_part HGNC:7712 ! NDUFS5 +relationship: has_part HGNC:7713 ! NDUFS6 +relationship: has_part HGNC:7719 ! NDUFV3 + +[Term] +id: FPLX:000501 +name: ETC-complex-I +xref: COMPLEXPORTAL:CPX-577 +xref: ECCODE:1.6.5.3 +xref: GO:0005747 +xref: HGNC_GROUP:640 +xref: MESH:D042967 +xref: NCIT:C118184 +is_a: FPLX:000000 ! famplex +relationship: has_part FPLX:000499 ! ETC_complex_I_core +relationship: has_part FPLX:000500 ! ETC_complex_I_supernumerary + +[Term] +id: FPLX:000502 +name: ETC-complex-II +synonym: "complex II" EXACT [] +synonym: "succinate dehydrogenase (ubiquinone)" EXACT [] +synonym: "succinate dehydrogenase" EXACT [] +xref: BEL:"Respiratory Chain Complex II" +xref: COMPLEXPORTAL:CPX-561 +xref: ECCODE:1.3.5.1 +xref: GO:0005749 +xref: HGNC_GROUP:641 +xref: MESH:D042963 +xref: NCIT:C112049 +xref: RE:R-HSA-165631 +xref: RE:R-HSA-70990 +is_a: FPLX:000000 ! famplex +relationship: has_part HGNC:10680 ! SDHA +relationship: has_part HGNC:10681 ! SDHB +relationship: has_part HGNC:10682 ! SDHC +relationship: has_part HGNC:10683 ! SDHD + +[Term] +id: FPLX:000503 +name: ETC-complex-III +synonym: "complex III" EXACT [] +synonym: "cytochrome bc1 complex" EXACT [] +xref: BEL:"Respiratory Chain Complex III" +xref: COMPLEXPORTAL:CPX-560 +xref: ECCODE:1.10.2.2 +xref: GO:0005750 +xref: GO:0045275 +xref: HGNC_GROUP:642 +xref: MESH:D014450 +is_a: FPLX:000000 ! famplex +relationship: has_part HGNC:2579 ! CYC1 +relationship: has_part HGNC:7427 ! MT-CYB +relationship: has_part HGNC:12582 ! UQCRB +relationship: has_part HGNC:12585 ! UQCRC1 +relationship: has_part HGNC:12586 ! UQCRC2 +relationship: has_part HGNC:12587 ! UQCRFS1 +relationship: has_part HGNC:12590 ! UQCRH +relationship: has_part HGNC:29594 ! UQCRQ +relationship: has_part HGNC:30863 ! UQCR10 +relationship: has_part HGNC:30862 ! UQCR11 + +[Term] +id: FPLX:000504 +name: ETC-complex-IV +xref: ECCODE:1.9.3.1 +xref: GO:0005751 +xref: HGNC_GROUP:643 +xref: MESH:D003576 +xref: NCIT:C26034 +is_a: FPLX:000000 ! famplex +relationship: has_part HGNC:2265 ! COX4I1 +relationship: has_part HGNC:16232 ! COX4I2 +relationship: has_part HGNC:2267 ! COX5A +relationship: has_part HGNC:2269 ! COX5B +relationship: has_part HGNC:2277 ! COX6A1 +relationship: has_part HGNC:2279 ! COX6A2 +relationship: has_part HGNC:2280 ! COX6B1 +relationship: has_part HGNC:24380 ! COX6B2 +relationship: has_part HGNC:2285 ! COX6C +relationship: has_part HGNC:2287 ! COX7A1 +relationship: has_part HGNC:2288 ! COX7A2 +relationship: has_part HGNC:2291 ! COX7B +relationship: has_part HGNC:24381 ! COX7B2 +relationship: has_part HGNC:2292 ! COX7C +relationship: has_part HGNC:2294 ! COX8A +relationship: has_part HGNC:24382 ! COX8C +relationship: has_part HGNC:7419 ! MT-CO1 +relationship: has_part HGNC:7421 ! MT-CO2 +relationship: has_part HGNC:7422 ! MT-CO3 + +[Term] +id: FPLX:000505 +name: ETC-complex-V +xref: ECCODE:3.6.3.14 +xref: GO:0005753 +xref: HGNC_GROUP:644 +xref: MESH:D025261 +is_a: FPLX:000000 ! famplex + diff --git a/famplex/resources/grounding_map.tsv b/famplex/resources/grounding_map.tsv new file mode 100644 index 000000000..4e7284c5e --- /dev/null +++ b/famplex/resources/grounding_map.tsv @@ -0,0 +1,2838 @@ +AMPK (alpha 1, beta 1, gamma 1) FPLX 000032 AMPK_A1B1G1 +AMPK (alpha 1, beta 1, gamma 2) FPLX 000033 AMPK_A1B1G2 +AMPK (alpha 1, beta 1, gamma 3) FPLX 000034 AMPK_A1B1G3 +AMPK (alpha 1, beta 2, gamma 1) FPLX 000035 AMPK_A1B2G1 +AMPK (alpha 1, beta 2, gamma 2) FPLX 000036 AMPK_A1B2G2 +AMPK (alpha 1, beta 2, gamma 3) FPLX 000037 AMPK_A1B2G3 +AMPK (alpha 2, beta 1, gamma 1) FPLX 000038 AMPK_A2B1G1 +AMPK (alpha 2, beta 1, gamma 2) FPLX 000039 AMPK_A2B1G2 +AMPK (alpha 2, beta 1, gamma 3) FPLX 000040 AMPK_A2B1G3 +AMPK (alpha 2, beta 2, gamma 1) FPLX 000041 AMPK_A2B2G1 +AMPK (alpha 2, beta 2, gamma 2) FPLX 000042 AMPK_A2B2G2 +AMPK (alpha 2, beta 2, gamma 3) FPLX 000043 AMPK_A2B2G3 +AMPK (α 1, β 1, γ 1) FPLX 000032 AMPK_A1B1G1 +AMPK (α 1, β 1, γ 2) FPLX 000033 AMPK_A1B1G2 +AMPK (α 1, β 1, γ 3) FPLX 000034 AMPK_A1B1G3 +AMPK (α 1, β 2, γ 1) FPLX 000035 AMPK_A1B2G1 +AMPK (α 1, β 2, γ 2) FPLX 000036 AMPK_A1B2G2 +AMPK (α 1, β 2, γ 3) FPLX 000037 AMPK_A1B2G3 +AMPK (α 2, β 1, γ 1) FPLX 000038 AMPK_A2B1G1 +AMPK (α 2, β 1, γ 2) FPLX 000039 AMPK_A2B1G2 +AMPK (α 2, β 1, γ 3) FPLX 000040 AMPK_A2B1G3 +AMPK (α 2, β 2, γ 1) FPLX 000041 AMPK_A2B2G1 +AMPK (α 2, β 2, γ 2) FPLX 000042 AMPK_A2B2G2 +AMPK (α 2, β 2, γ 3) FPLX 000043 AMPK_A2B2G3 +Glutamate receptors, ionotropic, kainate FPLX 000269 Kainate_family +Na(+),K(+)-ATPase FPLX 000303 Na_K_ATPase +Na,K-ATPase beta subunit FPLX 000058 ATP1B +Na,K-ATPase β subunit FPLX 000058 ATP1B +Na,K-ATPase FPLX 000303 Na_K_ATPase +(9-1-1) complex FPLX 000001 9_1_1 +14-3-3 proteins FPLX 000323 p14_3_3 +14-3-3 FPLX 000323 p14_3_3 +14-3-3zeta UP 1433Z_HUMAN P63104 +4E-BP1 UP 4EBP1_HUMAN Q13541 +4EBP FPLX 000154 EIF4EBP +4EBP1 UP 4EBP1_HUMAN Q13541 +53BP1 UP TP53B_HUMAN Q12888 +9-1-1 complex FPLX 000001 9_1_1 +9-1-1 FPLX 000001 9_1_1 +a-adrenoreceptor FPLX 000019 ADRA +a-cathenin FPLX 000126 CTNNA +A2t FPLX 000047 Annexin_II_heterotetramer +ABA PUBCHEM 5280896 . +ABA CHEBI (+)-abscisic acid CHEBI:2365 +Abeta UP A4_HUMAN P05067 +Abeta CHEBI amyloid-beta CHEBI:64645 +Abi1 UP ABI1_HUMAN Q8IZP0 +ABL family FPLX 000003 ABL_family +ABL FPLX 000003 ABL_family +Abl UP ABL1_HUMAN P00519 +AC MESH Adenocarcinoma D000230 +AC UP ADCY1_HUMAN Q08828 +ACAD FPLX 000004 ACAD +ACC FPLX 000005 ACC +ACCs FPLX 000005 ACC +Acetate-CoA ligase FPLX 000006 Acetyl_CoA_synthetase +acetyl CoA ligase FPLX 000006 Acetyl_CoA_synthetase +acetyl CoA synthase FPLX 000006 Acetyl_CoA_synthetase +Acetyl Coenzyme A Carboxylase FPLX 000005 ACC +Acetyl-CoA carboxylase FPLX 000005 ACC +acetyl-CoA carboxylase FPLX 000005 ACC +Acetyl-CoA synthetase FPLX 000006 Acetyl_CoA_synthetase +acetyl-CoA synthetase FPLX 000006 Acetyl_CoA_synthetase +acetyl-coenzyme A synthase FPLX 000006 Acetyl_CoA_synthetase +acetylcholine receptor FPLX 000102 CHRM +Ack1 UP ACK1_HUMAN Q07912 +ACS FPLX 000006 Acetyl_CoA_synthetase +Acsl FPLX 000008 ACSL +actin filament FPLX 000009 Actin +actin FPLX 000009 Actin +actinin FPLX 000014 ACTN +actins FPLX 000009 Actin +Activin A protein FPLX 000011 Activin_A +Activin A FPLX 000011 Activin_A +activin A FPLX 000011 Activin_A +activin AB FPLX 000012 Activin_AB +activin protein FPLX 000010 Activin +Activin FPLX 000010 Activin +activin FPLX 000010 Activin +activin-A FPLX 000011 Activin_A +activin-B FPLX 000013 Activin_B +activinA FPLX 000011 Activin_A +activins FPLX 000010 Activin +acyl CoA dehydrogenase FPLX 000004 ACAD +acyl-CoA dehydrogenase FPLX 000004 ACAD +Acyl-CoA Oxidase FPLX 000007 ACOX +acyl-CoA oxidases FPLX 000007 ACOX +Adaptor Protein 2 complex FPLX 000015 Adaptor_protein_II +adaptor protein complex 2 FPLX 000015 Adaptor_protein_II +adaptor protein complex 3 FPLX 000016 Adaptor_protein_III +adenylate cyclase FPLX 000017 ADCY +adenylyl cyclase FPLX 000017 ADCY +adhesion GO cell adhesion GO:0007155 +adhesion MESH Cell Adhesion D002448 +adiponectin UP ADIPO_HUMAN Q15848 +ADP CHEBI ADP CHEBI:16761 +ADP PUBCHEM 6022 . +ADP ribosylation factor FPLX 000053 ARF_GTPase_family +afatinib PUBCHEM 10184653 . +afatinib LINCS 10133-101 . +afatinib CHEBI afatinib CHEBI:61390 +AHR UP AHR_HUMAN P35869 +AICAR PUBCHEM 65110 . +AICAR CHEBI AICA ribonucleotide CHEBI:18406 +AKT family FPLX 000023 AKT +AKT FPLX 000023 AKT +Akt FPLX 000023 AKT +AKT1 UP AKT1_HUMAN P31749 +Akt1 UP AKT1_HUMAN P31749 +AKT2 UP AKT2_HUMAN P31751 +Akt2 UP AKT2_HUMAN P31751 +alcohol dehydrogenase FPLX 000018 ADH +alcohol PUBCHEM 702 . +alcohol CHEBI ethanol CHEBI:16236 +alcohol HMDB HMDB00108 . +aldehyde dehydrogenase (NAD+) FPLX 000024 ALDH +Aldehyde dehydrogenase FPLX 000024 ALDH +aldehyde dehydrogenase FPLX 000024 ALDH +ALDH FPLX 000024 ALDH +ALDO FPLX 000025 ALDO +aldosterone CHEBI aldosterone CHEBI:27584 +aldosterone PUBCHEM 5839 . +ALG10 FPLX 000026 ALG10 +ALIX HGNC 8766 PDCD6IP +ALIX UP PDC6I_HUMAN Q8WUM4 +ALK UP ALK_HUMAN Q9UM73 +alkali myosin light chains FPLX 000297 MYL_alkali +alpha adrenoceptor FPLX 000019 ADRA +alpha catenin FPLX 000126 CTNNA +alpha tubulin FPLX 000483 TUBA +alpha(2)-adrenoceptors FPLX 000020 ADRA2 +alpha(2)-ARs FPLX 000020 ADRA2 +alpha-adrenergic receptor FPLX 000019 ADRA +alpha-adrenoreceptor FPLX 000019 ADRA +alpha-adrenoreceptors FPLX 000019 ADRA +alpha-catenin FPLX 000126 CTNNA +alpha1 adrenoceptor FPLX 000019 ADRA +Alpha-1,2-glucosyltransferase FPLX 000026 ALG10 +Alpha-1,2-glucosyltransferases FPLX 000026 ALG10 +alpha-1,2-glucosyltransferase FPLX 000026 ALG10 +alpha-1,2-glucosyltransferases FPLX 000026 ALG10 +Alpha-1,3-glucosyltransferase FPLX 000029 ALG6_family +Alpha-1,3-glucosyltransferases FPLX 000029 ALG6_family +alpha-1,3-glucosyltransferase FPLX 000029 ALG6_family +alpha-1,3-glucosyltransferases FPLX 000029 ALG6_family +Alpha-1,4-glucosyltransferase FPLX 000029 ALG6_family +Alpha-1,4-glucosyltransferases FPLX 000029 ALG6_family +alpha-1,4-glucosyltransferase FPLX 000029 ALG6_family +alpha-1,4-glucosyltransferases FPLX 000029 ALG6_family +alpha1beta1gamma1 FPLX 000032 AMPK_A1B1G1 +alpha1beta1gamma2 FPLX 000033 AMPK_A1B1G2 +alpha1beta1gamma3 FPLX 000034 AMPK_A1B1G3 +alpha1beta2gamma1 FPLX 000035 AMPK_A1B2G1 +alpha1beta2gamma2 FPLX 000036 AMPK_A1B2G2 +alpha2 adrenoceptor FPLX 000020 ADRA2 +alpha2-AR FPLX 000020 ADRA2 +alpha2beta1 integrin FPLX 000261 Integrins +alpha2beta1gamma1 FPLX 000038 AMPK_A2B1G1 +alpha2beta2gamma1 FPLX 000041 AMPK_A2B2G1 +alpha2beta2gamma2 FPLX 000042 AMPK_A2B2G2 +alpha2beta2gamma3 FPLX 000043 AMPK_A2B2G3 +ALS UP ALS_HUMAN P35858 +AM HGNC 259 ADM +AM UP ADML_HUMAN P35318 +AM MESH Amnion D000650 +AMG655 MESH conatumumab C554537 +AMLC FPLX 000297 MYL_alkali +AMP HMDB HMDB00045 . +AMP CHEBI adenosine 5'-monophosphate CHEBI:16027 +AMP PUBCHEM 6083 . +AMPA glutamate receptor FPLX 000191 GRIA +AMPA receptor FPLX 000191 GRIA +AMPA-R FPLX 000191 GRIA +AMPA-subtype ionotropic glutamate receptors FPLX 000191 GRIA +AMPAR FPLX 000191 GRIA +AMPARs FPLX 000191 GRIA +AMPK (A1/B1/G1) FPLX 000032 AMPK_A1B1G1 +AMPK (A1/B1/G2) FPLX 000033 AMPK_A1B1G2 +AMPK (A1/B1/G3) FPLX 000034 AMPK_A1B1G3 +AMPK (A1/B2/G1) FPLX 000035 AMPK_A1B2G1 +AMPK (A1/B2/G2) FPLX 000036 AMPK_A1B2G2 +AMPK (A1/B2/G3) FPLX 000037 AMPK_A1B2G3 +AMPK (A2/B1/G1) FPLX 000038 AMPK_A2B1G1 +AMPK (A2/B1/G2) FPLX 000039 AMPK_A2B1G2 +AMPK (A2/B1/G3) FPLX 000040 AMPK_A2B1G3 +AMPK (A2/B2/G1) FPLX 000041 AMPK_A2B2G1 +AMPK (A2/B2/G2) FPLX 000042 AMPK_A2B2G2 +AMPK (A2/B2/G3) FPLX 000043 AMPK_A2B2G3 +AMPK a1b1g1 FPLX 000032 AMPK_A1B1G1 +AMPK a1b1g2 FPLX 000033 AMPK_A1B1G2 +AMPK a1b1g3 FPLX 000034 AMPK_A1B1G3 +AMPK a1b2g1 FPLX 000035 AMPK_A1B2G1 +AMPK a1b2g2 FPLX 000036 AMPK_A1B2G2 +AMPK a2b1g1 FPLX 000038 AMPK_A2B1G1 +AMPK a2b2g1 FPLX 000041 AMPK_A2B2G1 +AMPK a2b2g2 FPLX 000042 AMPK_A2B2G2 +AMPK a2b2g3 FPLX 000043 AMPK_A2B2G3 +AMPK alpha1beta1gamma1 FPLX 000032 AMPK_A1B1G1 +AMPK alpha1beta1gamma2 FPLX 000033 AMPK_A1B1G2 +AMPK alpha1beta1gamma3 FPLX 000034 AMPK_A1B1G3 +AMPK alpha1beta2gamma1 FPLX 000035 AMPK_A1B2G1 +AMPK alpha1beta2gamma2 FPLX 000036 AMPK_A1B2G2 +AMPK alpha1beta2gamma3 FPLX 000037 AMPK_A1B2G3 +AMPK alpha2beta1gamma1 FPLX 000038 AMPK_A2B1G1 +AMPK alpha2beta1gamma2 FPLX 000039 AMPK_A2B1G2 +AMPK alpha2beta1gamma3 FPLX 000040 AMPK_A2B1G3 +AMPK alpha2beta2gamma1 FPLX 000041 AMPK_A2B2G1 +AMPK alpha2beta2gamma2 FPLX 000042 AMPK_A2B2G2 +AMPK alpha2beta2gamma3 FPLX 000043 AMPK_A2B2G3 +AMPK α1β1γ1 FPLX 000032 AMPK_A1B1G1 +AMPK α1β1γ2 FPLX 000033 AMPK_A1B1G2 +AMPK α1β1γ3 FPLX 000034 AMPK_A1B1G3 +AMPK α1β2γ1 FPLX 000035 AMPK_A1B2G1 +AMPK α1β2γ2 FPLX 000036 AMPK_A1B2G2 +AMPK α1β2γ3 FPLX 000037 AMPK_A1B2G3 +AMPK α2β1γ1 FPLX 000038 AMPK_A2B1G1 +AMPK α2β1γ2 FPLX 000039 AMPK_A2B1G2 +AMPK α2β1γ3 FPLX 000040 AMPK_A2B1G3 +AMPK α2β2γ1 FPLX 000041 AMPK_A2B2G1 +AMPK α2β2γ2 FPLX 000042 AMPK_A2B2G2 +AMPK α2β2γ3 FPLX 000043 AMPK_A2B2G3 +AMPK FPLX 000031 AMPK +AMPK-alpha1 UP AAPK1_HUMAN Q13131 +AMPK-alpha2 UP AAPK2_HUMAN P54646 +AMPK-α1 UP AAPK1_HUMAN Q13131 +AMPK-α2 UP AAPK2_HUMAN P54646 +AMPKalpha FPLX 000044 AMPK_alpha +AMPKalpha1 catalytic domain UP AAPK1_HUMAN Q13131 +AMPKalpha1 UP AAPK1_HUMAN Q13131 +AMPKα FPLX 000044 AMPK_alpha +AMPKα1 catalytic domain UP AAPK1_HUMAN Q13131 +AMPKα1 UP AAPK1_HUMAN Q13131 +amyloid beta UP A4_HUMAN P05067 +amyloid beta CHEBI amyloid-beta CHEBI:64645 +amyloid β UP A4_HUMAN P05067 +amyloid β CHEBI amyloid-beta CHEBI:64645 +Ang II UP ANGT_HUMAN P01019 +AngII UP ANGT_HUMAN P01019 +angiogenesis GO angiogenesis GO:0001525 +angiogenesis MESH Neovascularization, Physiologic D018919 +annexin A2 heterotetramer FPLX 000047 Annexin_II_heterotetramer +annexin II heterotetramer FPLX 000047 Annexin_II_heterotetramer +ANXA2 heterotetramer FPLX 000047 Annexin_II_heterotetramer +AP-1 FPLX 000048 AP1 +AP-2 adaptor complex FPLX 000015 Adaptor_protein_II +AP-2 complex FPLX 000015 Adaptor_protein_II +AP-2 transcription factor FPLX 000463 TFAP2 +AP-2 FPLX 000015 Adaptor_protein_II +AP-3 FPLX 000016 Adaptor_protein_III +AP1 FPLX 000048 AP1 +AP2 adaptor complex FPLX 000015 Adaptor_protein_II +AP2 clathrin adaptor complex FPLX 000015 Adaptor_protein_II +AP2 complex FPLX 000015 Adaptor_protein_II +AP2 FPLX 000015 Adaptor_protein_II +AP3 FPLX 000016 Adaptor_protein_III +Apaf-1 UP APAF_HUMAN O14727 +APC UP APC_HUMAN P25054 +APC/C FPLX 000050 APC_C +apigenin CHEBI apigenin CHEBI:18388 +apigenin PUBCHEM 5280443 . +ApoA FPLX 000051 APOA +apoA FPLX 000051 APOA +apocynin CHEBI apocynin CHEBI:2781 +apocynin PUBCHEM 2214 . +apolipoprotein (a) FPLX 000051 APOA +apolipoprotein A FPLX 000051 APOA +apolipoprotein(A) FPLX 000051 APOA +apolipoprotein(a) FPLX 000051 APOA +Apolipoprotein FPLX 000052 Apolipoprotein +apolipoprotein FPLX 000052 Apolipoprotein +apolipoproteins FPLX 000052 Apolipoprotein +Apoptosis GO apoptotic process GO:0006915 +Apoptosis MESH Apoptosis D017209 +apoptosis GO apoptotic process GO:0006915 +apoptosis MESH Apoptosis D017209 +AR UP ANDR_HUMAN P10275 +ARF FPLX 000053 ARF_GTPase_family +ARF UP ARF_HUMAN Q8N726 +Arf UP ARF_HUMAN Q8N726 +Arp2/3 FPLX 000054 Arp2_3_protein +Arsenic trioxide CHEBI diarsenic trioxide CHEBI:30621 +Arsenic trioxide PUBCHEM 518605 . +arsenic PUBCHEM 5359596 . +arsenic CHEBI arsenic atom CHEBI:27563 +arsenite CHEBI arsenite(3-) CHEBI:29866 +arsenite PUBCHEM 544 . +artemisinin CHEBI (+)-artemisinin CHEBI:223316 +artemisinin PUBCHEM 68827 . +ASK1 UP M3K5_HUMAN Q99683 +aspirin PUBCHEM 2244 . +aspirin CHEBI acetylsalicylic acid CHEBI:15365 +ASPP1 UP ASPP1_HUMAN Q96KQ4 +ASPP2 UP ASPP2_HUMAN Q13625 +ATF2 UP ATF2_HUMAN P15336 +ATG4 FPLX 000056 ATG4 +Atg4 FPLX 000056 ATG4 +ATM UP ATM_HUMAN Q13315 +ATP synthase H + transporting mitochondrial F0 complex subunit G FPLX 000059 ATP5G +ATP synthase FPLX 000060 ATP_synthase +ATP HMDB HMDB00538 . +ATP PUBCHEM 5957 . +ATP CHEBI ATP CHEBI:15422 +ATP1A FPLX 000057 ATP1A +ATP1B FPLX 000058 ATP1B +ATPase Na+/K+ transporting subunit alpha FPLX 000057 ATP1A +ATPase Na+/K+ transporting subunit beta FPLX 000057 ATP1A +ATPase Na+/K+ transporting subunit α FPLX 000057 ATP1A +ATPase Na+/K+ transporting subunit β FPLX 000057 ATP1A +ATR UP ATR_HUMAN Q13535 +ATRA CHEBI all-trans-retinoic acid CHEBI:15367 +ATRA PUBCHEM 444795 . +autophagic cell death GO autophagic cell death GO:0048102 +Autophagy GO autophagy GO:0006914 +Autophagy MESH Autophagy D001343 +autophagy GO autophagy GO:0006914 +autophagy MESH Autophagy D001343 +Axin FPLX 000062 AXIN +AZD6244 CHEBI selumetinib CHEBI:90227 +AZD6244 PUBCHEM 10127622 . +Aβ UP A4_HUMAN P05067 +Aβ CHEBI amyloid-beta CHEBI:64645 +B3GAT FPLX 000063 B3GAT +b-adrenergic receptor FPLX 000021 ADRB +b-arrestin FPLX 000055 ARRB +B-Raf UP BRAF_HUMAN P15056 +b-receptors FPLX 000021 ADRB +B1 UP PLXB1_HUMAN O43157 +B1 UP CCNB1_HUMAN P14635 +BAD UP BAD_HUMAN Q92934 +Bad UP BAD_HUMAN Q92934 +Bak UP BAK_HUMAN Q16611 +Bam32 UP DAPP1_HUMAN Q9UN19 +BARK FPLX 000022 ADRBK +barrestins FPLX 000055 ARRB +BAX UP BAX_HUMAN Q07812 +Bax UP BAX_HUMAN Q07812 +BCKDC FPLX 000064 BCKDC +BCKDH FPLX 000064 BCKDC +BCL-2 UP BCL2_HUMAN P10415 +Bcl-2 UP BCL2_HUMAN P10415 +bcl-2 UP BCL2_HUMAN P10415 +Bcl-3 HGNC 998 BCL3 +Bcl-xL UP B2CL1_HUMAN Q07817 +BCL2 UP BCL2_HUMAN P10415 +Bcl2 UP BCL2_HUMAN P10415 +BCR UP BCR_HUMAN P11274 +Beclin-1 UP BECN1_HUMAN Q14457 +berberine CHEBI berberine CHEBI:16118 +berberine PUBCHEM 2353 . +Beta-1,3-glucuronyltransferase FPLX 000063 B3GAT +Beta-1,3-glucuronyltransferases FPLX 000063 B3GAT +beta-1,3-glucuronyltransferase FPLX 000063 B3GAT +beta-1,3-glucuronyltransferases FPLX 000063 B3GAT +Beta 3-glycosyltransferase FPLX 000065 Beta_3_4_GTF +Beta 3-glycosyltransferases FPLX 000065 Beta_3_4_GTF +beta 3-glycosyltransferase FPLX 000065 Beta_3_4_GTF +beta 3-glycosyltransferases FPLX 000065 Beta_3_4_GTF +Beta 4-glycosyltransferase FPLX 000065 Beta_3_4_GTF +Beta 4-glycosyltransferases FPLX 000065 Beta_3_4_GTF +beta 4-glycosyltransferase FPLX 000065 Beta_3_4_GTF +beta 4-glycosyltransferases FPLX 000065 Beta_3_4_GTF +beta adrenergic receptor kinase FPLX 000022 ADRBK +beta interferons FPLX 000247 IFNB +Beta Tubulin FPLX 000484 TUBB +Beta tubulin FPLX 000484 TUBB +beta Tubulin FPLX 000484 TUBB +beta tubulin FPLX 000484 TUBB +beta-adrenergic receptor FPLX 000021 ADRB +beta-adrenoreceptor FPLX 000021 ADRB +beta-catenin UP CTNB1_HUMAN P35222 +beta-TrCP UP FBW1A_HUMAN Q9Y297 +Beta-Tubulin FPLX 000484 TUBB +Beta-tubulin FPLX 000484 TUBB +beta-Tubulin FPLX 000484 TUBB +beta-tubulin FPLX 000484 TUBB +betaAR FPLX 000021 ADRB +betaARK FPLX 000022 ADRBK +BEZ235 PUBCHEM 11977753 . +BEZ235 CHEBI dactolisib CHEBI:71952 +bFGF UP FGF2_HUMAN P09038 +Bid UP BID_HUMAN P55957 +BIM UP B2L11_HUMAN O43521 +Bim UP B2L11_HUMAN O43521 +biosynthesis GO biosynthetic process GO:0009058 +BIRs FPLX 000066 BIRC +BITC PUBCHEM 2346 . +BITC CHEBI benzyl isothiocyanate CHEBI:17484 +BMF UP BMF_HUMAN Q96LC9 +BMI1 UP BMI1_HUMAN P35226 +BMP Receptor Type I FPLX 000069 BMP_receptor_type_I +BMP Receptor Type II FPLX 000070 BMP_receptor_type_II +BMP type I receptor FPLX 000069 BMP_receptor_type_I +BMP type II receptor FPLX 000070 BMP_receptor_type_II +BMP FPLX 000067 BMP +BMP9 UP GDF2_HUMAN Q9UK05 +bone morphogenetic protein I receptor FPLX 000069 BMP_receptor_type_I +bone morphogenetic protein receptor 1 FPLX 000069 BMP_receptor_type_I +bone morphogenetic protein receptor 2 FPLX 000070 BMP_receptor_type_II +bone morphogenetic protein receptor type I FPLX 000069 BMP_receptor_type_I +bone morphogenetic protein receptor type II FPLX 000070 BMP_receptor_type_II +bone morphogenetic protein type I receptors FPLX 000069 BMP_receptor_type_I +bone morphogenetic protein type II receptors FPLX 000070 BMP_receptor_type_II +bortezomib CHEBI bortezomib CHEBI:52717 +bortezomib PUBCHEM 387447 . +BPA CHEBI bisphenol A CHEBI:33216 +BPA PUBCHEM 6623 . +BRAF UP BRAF_HUMAN P15056 +branched-chain alpha-keto acid dehydrogenase complex FPLX 000064 BCKDC +branched-chain alpha-ketoacid dehydrogenase complex FPLX 000064 BCKDC +branched-chain α-keto acid dehydrogenase complex FPLX 000064 BCKDC +branched-chain α-ketoacid dehydrogenase complex FPLX 000064 BCKDC +BRCA FPLX 000071 BRCA +BRCA1 UP BRCA1_HUMAN P38398 +BRCA2 UP BRCA2_HUMAN P51587 +BRI FPLX 000069 BMP_receptor_type_I +BRII FPLX 000070 BMP_receptor_type_II +BRSK1 UP BRSK1_HUMAN Q8TDC3 +BRSK2 UP BRSK2_HUMAN Q8IWQ3 +Bub1 UP BUB1_HUMAN O43683 +BubR1 UP BUB1B_HUMAN O60566 +butein CHEBI butein CHEBI:3237 +butein PUBCHEM 5281222 . +c-Abl Kinase UP ABL1_HUMAN P00519 +c-Abl UP ABL1_HUMAN P00519 +c-Cbl protein UP CBL_HUMAN P22681 +c-Cbl UP CBL_HUMAN P22681 +c-FLIP UP CFLAR_HUMAN O15519 +c-Fos UP FOS_HUMAN P01100 +c-fos UP FOS_HUMAN P01100 +c-JNK FPLX 000267 JNK +c-Jun N-terminal kinase FPLX 000267 JNK +c-Jun NH2-terminal kinase FPLX 000267 JNK +c-Jun UP JUN_HUMAN P05412 +c-jun UP JUN_HUMAN P05412 +C-MAF UP MAF_HUMAN O75444 +c-MAF UP MAF_HUMAN O75444 +c-Maf UP MAF_HUMAN O75444 +c-maf UP MAF_HUMAN O75444 +c-MET HGNC 7029 MET +c-met HGNC 7029 MET +c-Met UP MET_HUMAN P08581 +c-Myb UP MYB_HUMAN P10242 +c-myc oncogene UP MYC_HUMAN P01106 +c-myc proteins UP MYC_HUMAN P01106 +c-MYC UP MYC_HUMAN P01106 +c-Myc UP MYC_HUMAN P01106 +c-myc UP MYC_HUMAN P01106 +C-PARP UP PARP1_HUMAN P09874 +c-Raf UP RAF1_HUMAN P04049 +c-Rel HGNC 9954 REL +c-src HGNC 11283 SRC +c-Src UP SRC_HUMAN P12931 +C/EBP FPLX 000097 CEBP +C/EBPalpha UP CEBPA_HUMAN P49715 +C/EBPbeta UP CEBPB_HUMAN P17676 +C/EBPβ UP CEBPB_HUMAN P17676 +C/EBPα UP CEBPA_HUMAN P49715 +c1 complex FPLX 000072 C1 +C1 FPLX 000072 C1 +C1-complex FPLX 000072 C1 +C1q FPLX 000073 C1q +Ca(2+)-calmodulin-dependent protein kinase II FPLX 000077 CAMK2_complex +Ca(2+)/calmodulin-dependent kinase II FPLX 000077 CAMK2_complex +Ca HMDB HMDB00464 . +Ca CHEBI calcium(2+) CHEBI:29108 +Ca PUBCHEM 271 . +cadherin FPLX 000074 Cadherin +caffeine PUBCHEM 2519 . +caffeine CHEBI caffeine CHEBI:27732 +Calcineurin catalytic subunit FPLX 000384 PPP3C +Calcineurin regulatory subunit FPLX 000385 PPP3R +calcineurin FPLX 000383 PPP3 +calcium HMDB HMDB00464 . +calcium CHEBI calcium(2+) CHEBI:29108 +calcium PUBCHEM 271 . +Calmodulin FPLX 000075 CALM +calmodulin FPLX 000075 CALM +calmodulindependent kinase II FPLX 000078 CAMK2_family +calpain FPLX 000079 CAPN +CaM kinase II FPLX 000077 CAMK2_complex +CaM FPLX 000075 CALM +CaMK family FPLX 000076 CAMK +CaMK II FPLX 000077 CAMK2_complex +CaMK FPLX 000076 CAMK +CAMK2 FPLX 000078 CAMK2_family +CaMK2 FPLX 000078 CAMK2_family +CaMKII FPLX 000077 CAMK2_complex +CAMKII FPLX 000078 CAMK2_family +cAMP PUBCHEM 6076 . +cAMP CHEBI 3',5'-cyclic AMP CHEBI:17489 +cAMP HMDB HMDB00058 . +cAMP-dependent PK FPLX 000363 PKA +cAMP-dependent protein kinase FPLX 000363 PKA +CaN FPLX 000383 PPP3 +CAP23 UP BASP1_HUMAN P80723 +CAPE PUBCHEM 5281787 . +CAPE CHEBI phenethyl caffeate CHEBI:8062 +capsaicin PUBCHEM 1548943 . +capsaicin CHEBI capsaicin CHEBI:3374 +carboxylesterase FPLX 000080 Carboxylesterase +carboxylesterases FPLX 000080 Carboxylesterase +CARP-1 UP CCAR1_HUMAN Q8IX12 +Cas UP BCAR1_HUMAN P56945 +Casein kinase 1 FPLX 000124 CSNK1 +casein kinase 1 FPLX 000124 CSNK1 +casein kinase 2 FPLX 000104 CK2 +casein kinase I FPLX 000124 CSNK1 +casein kinase II complex FPLX 000104 CK2 +casein kinase II FPLX 000104 CK2 +caspase 3 UP CASP3_HUMAN P42574 +caspase 8 UP CASP8_HUMAN Q14790 +caspase FPLX 000081 Caspase +caspase-1 UP CASP1_HUMAN P29466 +Caspase-3 UP CASP3_HUMAN P42574 +caspase-3 UP CASP3_HUMAN P42574 +caspase-3/7 FPLX 000082 Caspase_3_7 +caspase-8 UP CASP8_HUMAN Q14790 +caspase-9 UP CASP9_HUMAN P55211 +caspases FPLX 000081 Caspase +catalase UP CATA_HUMAN P04040 +catalytic subunit of calcineurin FPLX 000384 PPP3C +catenin alpha FPLX 000126 CTNNA +catenin α FPLX 000126 CTNNA +Caveolin FPLX 000083 CAV +caveolin FPLX 000083 CAV +caveolin-1 UP CAV1_HUMAN Q03135 +CBF3 complex FPLX 000084 CBF3 +CBF3 FPLX 000084 CBF3 +Cbl UP CBL_HUMAN P22681 +Cbl-b UP CBLB_HUMAN Q13191 +CBP UP CBP_HUMAN Q92793 +Cby UP CBY1_HUMAN Q9Y3M2 +CCAAT/enhancer binding protein FPLX 000097 CEBP +CCN2 UP CTGF_HUMAN P29279 +CCND1 UP CCND1_HUMAN P24385 +CCT complex FPLX 000085 CCT_complex +CCT FPLX 000085 CCT_complex +Cd PUBCHEM 23973 . +Cd CHEBI cadmium atom CHEBI:22977 +CD16 FPLX 000086 CD16 +CD24 UP CD24_HUMAN P25063 +CD28 UP CD28_HUMAN P10747 +CD3 FPLX 000087 CD3 +CD32 FPLX 000088 CD32 +CD4 UP CD4_HUMAN P01730 +CD44 UP CD44_HUMAN P16070 +CD64 FPLX 000089 CD64 +CD8 FPLX 000090 CD8 +CD95 UP TNR6_HUMAN P25445 +Cdc20 UP CDC20_HUMAN Q12834 +CDC25 family FPLX 000091 CDC25 +Cdc25 phosphatases FPLX 000091 CDC25 +CDC25 FPLX 000091 CDC25 +Cdc25 FPLX 000091 CDC25 +CDC42 UP CDC42_HUMAN P60953 +Cdc42 UP CDC42_HUMAN P60953 +Cdc6 UP CDC6_HUMAN Q99741 +CDDP CHEBI cisplatin CHEBI:27899 +CDDP PUBCHEM 441203 . +CDK FPLX 000092 CDK +Cdk FPLX 000092 CDK +CDK1 UP CDK1_HUMAN P06493 +Cdk1 UP CDK1_HUMAN P06493 +CDK2 UP CDK2_HUMAN P24941 +Cdk2 UP CDK2_HUMAN P24941 +cdk2 UP CDK2_HUMAN P24941 +CDK4 UP CDK4_HUMAN P11802 +Cdk4 UP CDK4_HUMAN P11802 +CDK6 UP CDK6_HUMAN Q00534 +CDK8 UP CDK8_HUMAN P49336 +CDK9 UP CDK9_HUMAN P50750 +CDKN FPLX 000094 CDKN +CDKN1 FPLX 000095 CDKN1 +CDKN1A UP CDN1A_HUMAN P38936 +CDKN2 FPLX 000096 CDKN2 +CDKs FPLX 000092 CDK +celecoxib PUBCHEM 2662 . +celecoxib CHEBI celecoxib CHEBI:41423 +cell adhesion GO cell adhesion GO:0007155 +cell adhesion MESH Cell Adhesion D002448 +cell cycle GO cell cycle GO:0007049 +cell cycle MESH Cell Cycle D002453 +cell death GO cell death GO:0008219 +cell death MESH Cell Death D016923 +cell growth GO cell growth GO:0016049 +cell growth MESH Cell Growth Processes D048708 +cell migration GO cell migration GO:0016477 +cell migration MESH Cell Movement D002465 +cell motility GO cell migration GO:0016477 +cell motility MESH Cell Movement D002465 +cell proliferation GO cell population proliferation GO:0008283 +cell proliferation MESH Cell Proliferation D049109 +cell survival MESH Cell Survival D002470 +cell viability MESH Cell Survival D002470 +cellular senescence GO cellular senescence GO:0090398 +cellular senescence MESH Cellular Senescence D016922 +ceramide CHEBI ceramide CHEBI:17761 +cetuximab CHEMBL 1201577 . +CFM-4 PUBCHEM 2871439 . +chaperonin containing TCP-1 FPLX 000085 CCT_complex +chaperonin FPLX 000085 CCT_complex +chaperonin-containing t-complex polypeptide 1 FPLX 000085 CCT_complex +chaperonin-containing TCP1 complex FPLX 000085 CCT_complex +checkpoint kinase FPLX 000098 CHEK +chemoattractant receptor FPLX 000100 Chemokine_receptor +chemokine FPLX 000099 Chemokine +chemokines FPLX 000099 Chemokine +CHIP UP CHIP_HUMAN Q9UNE7 +CHK1 UP CHK1_HUMAN O14757 +Chk1 UP CHK1_HUMAN O14757 +CHK2 UP CHK2_HUMAN O96017 +Chk2 UP CHK2_HUMAN O96017 +cholesterol CHEBI cholesterol CHEBI:16113 +cholesterol PUBCHEM 5997 . +choline esterase FPLX 000101 Cholinesterase +cholinesterase FPLX 000101 Cholinesterase +CHOP UP DDIT3_HUMAN P35638 +CIP1 UP CDN1A_HUMAN P38936 +CIP2A UP CIP2A_HUMAN Q8TCG1 +Cisplatin CHEBI cisplatin CHEBI:27899 +Cisplatin PUBCHEM 441203 . +cisplatin CHEBI cisplatin CHEBI:27899 +cisplatin PUBCHEM 441203 . +CK2 FPLX 000104 CK2 +CKI FPLX 000094 CDKN +Clade B serpin FPLX 000431 SERPINB +clade B serpins FPLX 000431 SERPINB +Class 1 NF-kappaBs FPLX 000312 NFkappaB_1 +class 1 NF-kappaBs FPLX 000312 NFkappaB_1 +Class 1 NF-κBs FPLX 000312 NFkappaB_1 +class 1 NF-κBs FPLX 000312 NFkappaB_1 +Class 2 NF-kappaBs FPLX 000313 NFkappaB_2 +class 2 NF-kappaBs FPLX 000313 NFkappaB_2 +Class 2 NF-κBs FPLX 000313 NFkappaB_2 +class 2 NF-κBs FPLX 000313 NFkappaB_2 +Class C GPCR FPLX 000187 GPCR +Class I HDACs FPLX 000221 HDAC_I +class I HDACs FPLX 000221 HDAC_I +class I histone deacetylases FPLX 000221 HDAC_I +Class I NF-kappaBs FPLX 000312 NFkappaB_1 +class I NF-kappaBs FPLX 000312 NFkappaB_1 +Class I NF-κBs FPLX 000312 NFkappaB_1 +class I NF-κBs FPLX 000312 NFkappaB_1 +class II HDACs FPLX 000222 HDAC_II +class II histone deacetylases FPLX 000222 HDAC_II +Class II NF-kappaBs FPLX 000313 NFkappaB_2 +class II NF-kappaBs FPLX 000313 NFkappaB_2 +Class II NF-κBs FPLX 000313 NFkappaB_2 +class II NF-κBs FPLX 000313 NFkappaB_2 +Class III HDACs FPLX 000223 HDAC_III +class III HDACs FPLX 000223 HDAC_III +class III histone deacetylases FPLX 000223 HDAC_III +Class IV HDACs FPLX 000224 HDAC_IV +class IV HDACs FPLX 000224 HDAC_IV +class IV histone deacetylases FPLX 000224 HDAC_IV +clathrin coat FPLX 000105 Clathrin +clathrin FPLX 000105 Clathrin +cleaved PARP UP PARP1_HUMAN P09874 +cMet receptor UP MET_HUMAN P08581 +CNKSR FPLX 000106 CNKSR +CO 2 CHEBI carbon dioxide CHEBI:16526 +CO 2 PUBCHEM 280 . +CO CHEBI carbon monoxide CHEBI:17245 +CO PUBCHEM 281 . +cocaine PUBCHEM 446220 . +cocaine CHEBI cocaine CHEBI:27958 +cofilin FPLX 000107 Cofilin +cohesin complex FPLX 000108 Cohesin +cohesin FPLX 000108 Cohesin +Col4 FPLX 000110 COL4 +COLGALT FPLX 000112 COLGALT +ColIV FPLX 000110 COL4 +Collagen beta(1-O)galactosyltransferase FPLX 000112 COLGALT +Collagen beta(1-O)galactosyltransferases FPLX 000112 COLGALT +collagen beta(1-O)galactosyltransferase FPLX 000112 COLGALT +collagen beta(1-O)galactosyltransferases FPLX 000112 COLGALT +collagen IV FPLX 000110 COL4 +collagen type I FPLX 000109 COL1 +Collagen Type IV FPLX 000110 COL4 +collagen type IV FPLX 000110 COL4 +collagen type V FPLX 000111 COL5 +collagen MESH Collagen D003094 +collagen CHEBI Collagen CHEBI:3815 +complex II FPLX 000502 ETC_complex_II +complex III FPLX 000503 ETC_complex_III +Complex IV FPLX 000113 COX +connector enhancer of kinase suppressor of ras FPLX 000106 CNKSR +copper CHEBI copper(2+) CHEBI:29036 +copper PUBCHEM 27099 . +cortactin IP IPR015503 . +cortactin UP SRC8_HUMAN Q14247 +COX-2 UP PGH2_HUMAN P35354 +Cox4 FPLX 000114 COX4 +COX6A FPLX 000115 COX6A +Cox6a FPLX 000115 COX6A +Cox6b FPLX 000116 COX6B +COX7A FPLX 000117 COX7A +Cox7a FPLX 000117 COX7A +Cox7b FPLX 000118 COX7B +Cox8 FPLX 000119 COX8 +cPARP UP PARP1_HUMAN P09874 +cPLA2 FPLX 000366 PLA2 +CRAF UP RAF1_HUMAN P04049 +CREB family FPLX 000120 CREB +CREB FPLX 000120 CREB +CRISP FPLX 000121 CRISP +CRISPs FPLX 000121 CRISP +Crk UP CRK_HUMAN P46108 +CRSP complex FPLX 000122 CRSP +CRSP FPLX 000122 CRSP +CRSP/Med complex FPLX 000122 CRSP +CsA PUBCHEM 5284373 . +CsA CHEBI cyclosporin A CHEBI:4031 +CSC MESH Neoplastic Stem Cells D014411 +CSF-1R UP CSF1R_HUMAN P07333 +CSNK1 FPLX 000124 CSNK1 +CSNK2 FPLX 000125 CSNK2 +CtIP UP CTIP_HUMAN Q99708 +cTnC FPLX 000478 Troponin_C +cTnI FPLX 000478 Troponin_C +cTnT FPLX 000480 Troponin_T +cullin proteins FPLX 000127 CUL +cullin FPLX 000127 CUL +cullins FPLX 000127 CUL +Curcumin CHEBI curcumin CHEBI:3962 +Curcumin PUBCHEM 969516 . +curcumin CHEBI curcumin CHEBI:3962 +curcumin PUBCHEM 969516 . +CXCL12 UP SDF1_HUMAN P48061 +CXCL8 UP IL8_HUMAN P10145 +CXCR2 UP CXCR2_HUMAN P25025 +CXCR4 UP CXCR4_HUMAN P61073 +cyclic AMP-dependent protein kinase FPLX 000363 PKA +cyclic-AMP-dependent protein kinase FPLX 000363 PKA +Cyclin A FPLX 000131 Cyclin_A +cyclin A FPLX 000131 Cyclin_A +Cyclin D FPLX 000132 Cyclin_D +Cyclin D2 UP CCND2_HUMAN P30279 +cyclin D2 UP CCND2_HUMAN P30279 +cyclin dependent kinase inhibitors FPLX 000094 CDKN +cyclin E FPLX 000133 Cyclin_E +cyclin family FPLX 000130 Cyclin +Cyclin FPLX 000130 Cyclin +cyclin FPLX 000130 Cyclin +Cyclin-A FPLX 000131 Cyclin_A +cyclin-dependent kinase inhibitor FPLX 000094 CDKN +cyclin-dependent protein kinase inhibitors FPLX 000094 CDKN +cyclins FPLX 000130 Cyclin +cyclophilin FPLX 000134 Cyclophilin +cyclophilins FPLX 000134 Cyclophilin +CYLD UP CYLD_HUMAN Q9NQC7 +cypermethrin CHEBI cypermethrin CHEBI:4042 +cypermethrin PUBCHEM 2912 . +cysteine rich secretory proteins FPLX 000121 CRISP +cysteine-rich secretory proteins FPLX 000121 CRISP +cytochrome bc1 complex FPLX 000503 ETC_complex_III +Cytochrome c oxidase subunit 6a FPLX 000115 COX6A +cytochrome c oxidase subunit VIII FPLX 000119 COX8 +cytochrome c oxidase FPLX 000113 COX +cytochrome C UP CYC_HUMAN P99999 +cytochrome c UP CYC_HUMAN P99999 +cytokine production GO cytokine production GO:0001816 +cytoplasmic dynein FPLX 000135 Cytoplasmic_dynein +cytosolic phospholipase A(2) FPLX 000366 PLA2 +cytosolic phospholipase A2 FPLX 000366 PLA2 +cytosolic PLA2 FPLX 000366 PLA2 +DA PUBCHEM 681 . +DA CHEBI dopamine CHEBI:18243 +dabrafenib PUBCHEM 44462760 . +dabrafenib CHEBI dabrafenib CHEBI:75045 +DAG kinase FPLX 000140 DGK +DAG PUBCHEM 6026790 . +DAG CHEBI diacylglycerol 30:1 CHEBI:85682 +damage MESH DNA Damage D004249 +Danusertib PUBCHEM 11442891 . +Danusertib CHEMBL CHEMBL402548 . +Danusertib CHEBI N-[5-[(2R)-2-methoxy-1-oxo-2-phenylethyl]-4,6-dihydro-1H-pyrrolo[3,4-c]pyrazol-3-yl]-4-(4-methyl-1-piperazinyl)benzamide CHEBI:94490 +danusertib PUBCHEM 11442891 . +danusertib CHEMBL CHEMBL402548 . +danusertib CHEBI N-[5-[(2R)-2-methoxy-1-oxo-2-phenylethyl]-4,6-dihydro-1H-pyrrolo[3,4-c]pyrazol-3-yl]-4-(4-methyl-1-piperazinyl)benzamide CHEBI:94490 +dapagliflozin CHEBI dapagliflozin CHEBI:85078 +dapagliflozin PUBCHEM 9887712 . +dasatinib CHEBI dasatinib (anhydrous) CHEBI:49375 +dasatinib PUBCHEM 3062316 . +DDR GO DNA damage response, detection of DNA damage GO:0042769 +death receptor FPLX 000137 Death_receptor +death receptors FPLX 000137 Death_receptor +death GO cell death GO:0008219 +death MESH Cell Death D016923 +delta-tubulin HGNC 16811 TUBD1 +desmoglein FPLX 000138 Desmoglein +desmogleins FPLX 000138 Desmoglein +dexamethasone PUBCHEM 5743 . +dexamethasone CHEBI dexamethasone CHEBI:41879 +DGC FPLX 000139 DGC +DGK FPLX 000140 DGK +DHA CHEBI dihydroartemisinin CHEBI:207229 +DHA PUBCHEM 6918483 . +DHT PUBCHEM 11302 . +DHT CHEBI 5beta-dihydrotestosterone CHEBI:2150 +diacyl glycerol kinase FPLX 000140 DGK +diacylglycerol kinase FPLX 000140 DGK +differentiation GO cell differentiation GO:0030154 +differentiation MESH Cell Differentiation D002454 +diosmetin CHEBI diosmetin CHEBI:4630 +diosmetin PUBCHEM 5281612 . +discoidin domain receptor family FPLX 000136 DDR +discoidin domain receptors FPLX 000136 DDR +discoidin domain-containing receptor FPLX 000136 DDR +dishevelled FPLX 000145 DVL +DNA polymerase delta FPLX 000141 DNA_polymerase_delta +DNA polymerase δ FPLX 000141 DNA_polymerase_delta +DNA repair GO DNA repair GO:0006281 +DNA repair MESH DNA Repair D004260 +DNA replication factor C complex FPLX 000411 RFC +DNA replication factor C FPLX 000411 RFC +DNA-PKcs UP PRKDC_HUMAN P78527 +DNA-Pkcs UP PRKDC_HUMAN P78527 +docetaxel PUBCHEM 148124 . +docetaxel CHEBI docetaxel anhydrous CHEBI:4672 +Dok1 UP DOK1_HUMAN Q99704 +Dok2 UP DOK2_HUMAN O60496 +dopamine receptor FPLX 000143 DRD +dopamine receptors FPLX 000143 DRD +dopamine PUBCHEM 681 . +dopamine CHEBI dopamine CHEBI:18243 +doxorubicin CHEBI doxorubicin CHEBI:28748 +doxorubicin PUBCHEM 31703 . +doxycycline PUBCHEM 54671203 . +doxycycline CHEBI doxycycline CHEBI:50845 +DP complex FPLX 000464 TFDP +DR4 UP TR10A_HUMAN O00220 +DR5 UP TR10B_HUMAN O14763 +DSB MESH DNA Breaks, Double-Stranded D053903 +DUSP FPLX 000144 DUSP +DUSP1 UP DUS1_HUMAN P28562 +Dvl FPLX 000145 DVL +dynamin family FPLX 000142 DNM +dynamin FPLX 000142 DNM +dystrophin glycoprotein complex FPLX 000139 DGC +dystrophin glycoprotein FPLX 000139 DGC +dystrophin-associated glycoprotein complex FPLX 000139 DGC +dystrophin-glycoprotein complex FPLX 000139 DGC +E-cadherin UP CADH1_HUMAN P12830 +E2 enzyme FPLX 000489 UBE2 +E2 ubiquitin-conjugating enzyme FPLX 000489 UBE2 +E2 FPLX 000489 UBE2 +E2 UP POLG_HCVH P27958 +E2F FPLX 000147 E2F +E2F-1 UP E2F1_HUMAN Q01094 +E2F1 UP E2F1_HUMAN Q01094 +E3 ubiquitin ligase FPLX 000148 E3_Ub_ligase +E3 FPLX 000148 E3_Ub_ligase +E6 UP VE6_HPV16 P03126 +E7 UP VE7_HPV16 P03129 +early growth response proteins FPLX 000151 EGR +EBNA3C UP None I1YP21 +ECM GO extracellular matrix GO:0031012 +Ect2 UP ECT2_HUMAN Q9H8V3 +EGCG PUBCHEM 65064 . +EGCG CHEBI (-)-epigallocatechin 3-gallate CHEBI:4806 +EGF receptor UP EGFR_HUMAN P00533 +EGF UP EGF_HUMAN P01133 +EGFR ligand FPLX 000150 EGFR_ligand +EGFR ligands FPLX 000150 EGFR_ligand +EGFR UP EGFR_HUMAN P00533 +EGFRvIII UP EGFR_HUMAN P00533 +EGR FPLX 000151 EGR +eIF2alpha UP IF2A_HUMAN P05198 +EIF2B FPLX 000152 EIF2B +eIF2B FPLX 000152 EIF2B +eIF2α UP IF2A_HUMAN P05198 +eIF4A FPLX 000153 EIF4A +eIF4E UP IF4E_HUMAN P06730 +eIF4G FPLX 000155 EIF4G +elastase FPLX 000156 ELA +Elk-1 UP ELK1_HUMAN P19419 +Elk1 UP ELK1_HUMAN P19419 +ELMO1 UP ELMO1_HUMAN Q92556 +ELR (+) CXC chemokines FPLX 000129 CXCL_ELR_positive +ELR (-) CXC chemokines FPLX 000128 CXCL_ELR_negative +ELR-negative CXC chemokine FPLX 000128 CXCL_ELR_negative +ELR-negative CXC family FPLX 000128 CXCL_ELR_negative +ELR-positive CXC chemokine FPLX 000129 CXCL_ELR_positive +ELR-positive CXC family FPLX 000129 CXCL_ELR_positive +embelin CHEBI embelin CHEBI:4778 +embelin PUBCHEM 3218 . +emodin PUBCHEM 3220 . +emodin CHEBI emodin CHEBI:42223 +EMT GO epithelial to mesenchymal transition GO:0001837 +EMT MESH Epithelial-Mesenchymal Transition D058750 +endocytosis GO endocytosis GO:0006897 +endocytosis MESH Endocytosis D004705 +endothelin FPLX 000149 EDN +endothelins FPLX 000149 EDN +enolase FPLX 000157 ENO +eNOS UP NOS3_HUMAN P29474 +Env UP None U3LIR9 +Eph receptor FPLX 000158 Ephrin_receptor +Eph receptors FPLX 000158 Ephrin_receptor +EphA2 UP EPHA2_HUMAN P29317 +EphB1 UP EPHB1_HUMAN P54762 +ephrin receptor FPLX 000158 Ephrin_receptor +epidermal growth factor receptor UP EGFR_HUMAN P00533 +epidermal growth factor UP EGF_HUMAN P01133 +Eps8 UP EPS8_HUMAN Q12929 +epsilon-tubulin HGNC 20775 TUBE1 +epsin FPLX 000159 EPN +epsins FPLX 000159 EPN +ER FPLX 000162 ESR +ER MESH Endoplasmic Reticulum D004721 +ER GO endoplasmic reticulum GO:0005783 +ER UP ESR1_HUMAN P03372 +ERalpha UP ESR1_HUMAN P03372 +ErbB FPLX 000160 ERBB +ERBB2 UP ERBB2_HUMAN P04626 +ErbB2 UP ERBB2_HUMAN P04626 +ErbB3 UP ERBB3_HUMAN P21860 +ERK 1/2 FPLX 000161 ERK +ERK inhibitors CHEBI EC 2.7.11.24 (mitogen-activated protein kinase) inhibitor CHEBI:79091 +ERK MAPK FPLX 000161 ERK +ERK mitogen-activated protein kinase FPLX 000161 ERK +ERK FPLX 000161 ERK +Erk FPLX 000161 ERK +ERK-1/2 FPLX 000161 ERK +ERK1 UP MK03_HUMAN P27361 +Erk1 UP MK03_HUMAN P27361 +ERK1/2 MAPK FPLX 000161 ERK +ERK1/2 FPLX 000161 ERK +Erk1/2 FPLX 000161 ERK +ERK2 UP MK01_HUMAN P28482 +ERK5 UP MK07_HUMAN Q13164 +ERKs FPLX 000161 ERK +erlotinib PUBCHEM 176870 . +erlotinib CHEBI erlotinib CHEBI:114785 +ERα UP ESR1_HUMAN P03372 +ESR FPLX 000162 ESR +estradiol CHEBI estradiol CHEBI:23965 +estradiol PUBCHEM 9811784 . +estrogen receptor UP ESR1_HUMAN P03372 +estrogen CHEBI estrogen CHEBI:50114 +ET-1 UP EDN1_HUMAN P05305 +ethanol PUBCHEM 702 . +ethanol CHEBI ethanol CHEBI:16236 +ethanol HMDB HMDB00108 . +etoposide PUBCHEM 36462 . +etoposide CHEBI etoposide CHEBI:4911 +ETS FPLX 000163 ETS +ETS-1 UP ETS1_HUMAN P14921 +Ets-1 UP ETS1_HUMAN P14921 +ETS1 UP ETS1_HUMAN P14921 +eukaryotic initiation factor 4E UP IF4E_HUMAN P06730 +eukaryotic initiation factor-4A FPLX 000153 EIF4A +Everolimus PUBCHEM 6442177 . +Everolimus CHEBI everolimus CHEBI:68478 +everolimus PUBCHEM 6442177 . +everolimus CHEBI everolimus CHEBI:68478 +EXOC FPLX 000164 EXOC +exocyst complex FPLX 000164 EXOC +exocyst FPLX 000164 EXOC +Exostosin glycosyltransferase family FPLX 000165 EXT +exostosin glycosyltransferase family FPLX 000165 EXT +EXT FPLX 000165 EXT +Extracellular Signal Regulated Kinase FPLX 000161 ERK +extracellular signal-regulated kinase FPLX 000161 ERK +EZH2 UP EZH2_HUMAN Q15910 +ezrin UP EZRI_HUMAN P15311 +F-actin FPLX 000178 F_actin +FADD UP FADD_HUMAN Q13158 +FAK UP FAK1_HUMAN Q05397 +FAM83B UP FA83B_HUMAN Q5T0W9 +FANC proteins FPLX 000166 FANC +FANC FPLX 000166 FANC +FANCJ UP FANCJ_HUMAN Q9BX63 +farnesyltransferase FPLX 000172 FNT +Fas UP TNR6_HUMAN P25445 +FasL UP TNFL6_HUMAN P48023 +FGF FPLX 000167 FGF +FGF-2 UP FGF2_HUMAN P09038 +FGF2 UP FGF2_HUMAN P09038 +FGFR FPLX 000168 FGFR +FGFR1 UP FGFR1_HUMAN P11362 +FGFR2 UP FGFR2_HUMAN P21802 +FGFR3 UP FGFR3_HUMAN P22607 +FGFR4 UP FGFR4_HUMAN P22455 +fibrinogen FPLX 000169 Fibrinogen +fibronectin UP FINC_HUMAN P02751 +fisetin CHEBI fisetin CHEBI:42567 +fisetin PUBCHEM 5281614 . +Flip UP CFLAR_HUMAN O15519 +flotillin FPLX 000170 FLOT +FLRT family FPLX 000171 FLRT +Flrt family FPLX 000171 FLRT +FLRT proteins FPLX 000171 FLRT +FLT3 UP FLT3_HUMAN P36888 +FN UP FINC_HUMAN P02751 +follicle-stimulating hormone FPLX 000175 FSH +FOS FPLX 000173 FOS_family +Fos FPLX 000173 FOS_family +FOXM1 UP FOXM1_HUMAN Q08050 +FOXO FPLX 000174 FOXO +FoxO FPLX 000174 FOXO +FOXO1 UP FOXO1_HUMAN Q12778 +FoxO1 UP FOXO1_HUMAN Q12778 +FOXO3 UP FOXO3_HUMAN O43524 +FOXO3a UP FOXO3_HUMAN O43524 +FoxO3a UP FOXO3_HUMAN O43524 +FRK UP FRK_HUMAN P42685 +fructose-bisphosphate aldolase FPLX 000025 ALDO +FSH FPLX 000175 FSH +FTase FPLX 000172 FNT +FTS PUBCHEM 5469318 . +Fucosyltransferase FPLX 000176 FUT +Fucosyltransferases FPLX 000176 FUT +fucosyltransferase FPLX 000176 FUT +fucosyltransferases FPLX 000176 FUT +FUT FPLX 000176 FUT +Fyn UP FYN_HUMAN P06241 +Fz FPLX 000177 FZD +FZD FPLX 000177 FZD +G 1 GO G1 phase GO:0051318 +G 1 MESH G1 Phase D016193 +G 2 MESH G2 Phase D016195 +G alphai FPLX 000213 G_i_alpha +G alphaq FPLX 000216 G_q_alpha +G alphaS FPLX 000218 G_s_alpha +G protein beta FPLX 000210 G_beta +G protein gamma subunit FPLX 000211 G_gamma +G protein gamma FPLX 000211 G_gamma +G protein Gs FPLX 000217 G_s +G protein γ subunit FPLX 000211 G_gamma +G protein β FPLX 000210 G_beta +G protein γ FPLX 000211 G_gamma +G protein(s) FPLX 000217 G_s +G protein FPLX 000214 G_protein +G protein-coupled receptor kinases FPLX 000192 GRK +G proteins FPLX 000214 G_protein +G S protein FPLX 000217 G_s +G αi FPLX 000213 G_i_alpha +G αq FPLX 000216 G_q_alpha +G αS FPLX 000218 G_s_alpha +G(12) FPLX 000207 G_12 +G(q/11) FPLX 000215 G_q +G-alpha(s) FPLX 000218 G_s_alpha +G-AlphaS FPLX 000218 G_s_alpha +G-protein alpha-12 FPLX 000208 G_12_alpha +G-Protein alpha-i FPLX 000213 G_i_alpha +G-Protein alpha-q FPLX 000216 G_q_alpha +G-Protein alpha-s FPLX 000218 G_s_alpha +G-protein beta FPLX 000210 G_beta +G-protein β FPLX 000210 G_beta +G-protein α-12 FPLX 000208 G_12_alpha +G-Protein α-i FPLX 000213 G_i_alpha +G-Protein α-q FPLX 000216 G_q_alpha +G-Protein α-s FPLX 000218 G_s_alpha +G-α(s) FPLX 000218 G_s_alpha +G-αS FPLX 000218 G_s_alpha +G12 family FPLX 000207 G_12 +G12 proteins FPLX 000207 G_12 +G12 FPLX 000207 G_12 +GA PUBCHEM 370 . +GA CHEBI gallic acid CHEBI:30778 +Ga12 FPLX 000208 G_12_alpha +Gab1 UP GAB1_HUMAN Q13480 +Gab2 UP GAB2_HUMAN Q9UQC2 +GABA receptor FPLX 000179 GABR +GABA receptors FPLX 000179 GABR +GABA-A receptor FPLX 000179 GABR +GALNT FPLX 000180 GALNT +Galpha12 FPLX 000208 G_12_alpha +Galphai FPLX 000213 G_i_alpha +Galphaq FPLX 000216 G_q_alpha +GalphaS FPLX 000218 G_s_alpha +gamma secretase FPLX 000181 Gamma_secretase +Gamma tubulin FPLX 000485 TUBG +gamma tubulin FPLX 000485 TUBG +gamma-aminobutyric-acid A receptor FPLX 000179 GABR +gamma-secretase FPLX 000181 Gamma_secretase +gamma-tubulin FPLX 000485 TUBG +GAP FPLX 000182 GAP +Gas6 receptors FPLX 000183 GAS6_receptor +gastrin UP GAST_HUMAN P01350 +GATA family FPLX 000184 GATA +GATA FPLX 000184 GATA +Gbeta FPLX 000210 G_beta +GCNT FPLX 000185 GCNT +GDF15 UP GDF15_HUMAN Q99988 +GDP HMDB HMDB01201 . +GDP PUBCHEM 135398619 . +GDP CHEBI GDP CHEBI:17552 +GEF FPLX 000186 GEF +GEF-H1 UP ARHG2_HUMAN Q92974 +gefitinib PUBCHEM 123631 . +gefitinib CHEBI gefitinib CHEBI:49668 +GEFs FPLX 000186 GEF +general transcription factor II E FPLX 000196 GTF2E +general transcription factor II F FPLX 000197 GTF2F +genistein CHEBI genistein CHEBI:28088 +genistein PUBCHEM 5280961 . +Gi alpha subunit FPLX 000213 G_i_alpha +Gi alpha FPLX 000213 G_i_alpha +Gi protein FPLX 000212 G_i +Gi α subunit FPLX 000213 G_i_alpha +Gi α FPLX 000213 G_i_alpha +Gi FPLX 000212 G_i +GII PLA2 FPLX 000367 PLA2G2 +GIIPLA2 FPLX 000367 PLA2G2 +gIV-PLA(2) FPLX 000368 PLA2G4 +glucose transporter FPLX 000434 SLC2A +glucose transporters FPLX 000434 SLC2A +Glucose HMDB HMDB00122 . +glucose HMDB HMDB00122 . +GLUT FPLX 000434 SLC2A +glutamate metabotropic receptors FPLX 000193 GRM +glutathione peroxidase FPLX 000190 GPX +glutathione S-transferase FPLX 000195 GST +glutathione PUBCHEM 124886 . +glutathione CHEBI glutathione CHEBI:16856 +glutathione HMDB HMDB00125 . +Glycogen phosphorylase FPLX 000396 PYG +Glycogen phosphorylases FPLX 000396 PYG +glycogen phosphorylase FPLX 000396 PYG +glycogen phosphorylases FPLX 000396 PYG +glycogen synthase FPLX 000206 GYS +glycolysis GO glycolytic process GO:0006096 +glycolysis MESH Glycolysis D006019 +glycoprotein Ib-V-IX complex FPLX 000188 GPIb_IX_V +Glycoprotein Ib-V-IX FPLX 000188 GPIb_IX_V +Glycoprotein Ib/V/IX FPLX 000188 GPIb_IX_V +glycosylphosphatidylinositol transamidase complex FPLX 000189 GPIT +Glycosyltransferase family 2 FPLX 000199 GTF_family_2 +glycosyltransferase family 2 FPLX 000199 GTF_family_2 +Glycosyltransferase family 29 FPLX 000202 GTF_family_29 +glycosyltransferase family 29 FPLX 000202 GTF_family_29 +Glycosyltransferase family 6 FPLX 000200 GTF_family_6 +glycosyltransferase family 6 FPLX 000200 GTF_family_6 +Glycosyltransferase family 8 FPLX 000201 GTF_family_8 +glycosyltransferase family 8 FPLX 000201 GTF_family_8 +Glycosyltransferase family 90 FPLX 000203 GTF_family_90 +glycosyltransferase family 90 FPLX 000203 GTF_family_90 +gp120 UP ENV_HV1H2 P04578 +gp47 phox UP NCF1_HUMAN P14598 +gp91 phox UP CY24B_HUMAN P04839 +GPCR kinases FPLX 000192 GRK +GPCR FPLX 000187 GPCR +GPCRs FPLX 000187 GPCR +GPI transamidase complex FPLX 000189 GPIT +GPIb-IX-V complex FPLX 000188 GPIb_IX_V +GPIb-IX-V FPLX 000188 GPIb_IX_V +GpIb-V-IX FPLX 000188 GPIb_IX_V +GPIT complex FPLX 000189 GPIT +GPIT FPLX 000189 GPIT +Gq alpha subunit FPLX 000216 G_q_alpha +Gq alpha FPLX 000216 G_q_alpha +Gq α subunit FPLX 000216 G_q_alpha +Gq α FPLX 000216 G_q_alpha +Gq/11 FPLX 000215 G_q +GR UP GSHR_HUMAN P00390 +GRB2 UP GRB2_HUMAN P62993 +Grb2 UP GRB2_HUMAN P62993 +GRK FPLX 000192 GRK +GRKs FPLX 000192 GRK +group IV-PLA(2) FPLX 000368 PLA2G4 +GRP78 UP BIP_HUMAN P11021 +Gs alpha subunit FPLX 000218 G_s_alpha +Gs alpha FPLX 000218 G_s_alpha +Gs family FPLX 000217 G_s +Gs protein FPLX 000217 G_s +Gs α subunit FPLX 000218 G_s_alpha +Gs α FPLX 000218 G_s_alpha +GSH PUBCHEM 124886 . +GSH CHEBI glutathione CHEBI:16856 +GSH HMDB HMDB00125 . +GSK-3 FPLX 000194 GSK3 +GSK-3beta UP GSK3B_HUMAN P49841 +GSK-3β UP GSK3B_HUMAN P49841 +GSK3 FPLX 000194 GSK3 +GSK3beta UP GSK3B_HUMAN P49841 +GSK3β UP GSK3B_HUMAN P49841 +GST FPLX 000195 GST +GSTs FPLX 000195 GST +GTP HMDB HMDB01273 . +GTP CHEBI GTP CHEBI:15996 +GTP PUBCHEM 135398633 . +GTPase FPLX 000204 GTPase +GTPase-activating proteins FPLX 000182 GAP +guanine PUBCHEM 135398634 . +guanine CHEBI guanine CHEBI:16235 +guanylate cyclase FPLX 000205 GUCY +guanylyl cyclase FPLX 000205 GUCY +G_alpha FPLX 000209 G_alpha +G_α FPLX 000209 G_alpha +Gβ FPLX 000210 G_beta +Gα12 FPLX 000208 G_12_alpha +Gαi FPLX 000213 G_i_alpha +Gαq FPLX 000216 G_q_alpha +GαS FPLX 000218 G_s_alpha +H-Ras UP RASH_HUMAN P01112 +H/R MESH Cell Hypoxia D015687 +H2AX UP H2AX_HUMAN P16104 +H2B FPLX 000236 Histone_H2B +H3 FPLX 000237 Histone_H3 +h9-1-1 complex FPLX 000001 9_1_1 +haem oxygenase FPLX 000240 HMOX +hAxin FPLX 000062 AXIN +HB-EGF UP HBEGF_HUMAN Q99075 +HBx UP None Q157B2 +hCG FPLX 000219 hCG +HDAC inhibitor CHEBI EC 3.5.1.98 (histone deacetylase) inhibitor CHEBI:61115 +HDAC FPLX 000220 HDAC +HDAC1 UP HDAC1_HUMAN Q13547 +HDAC2 UP HDAC2_HUMAN Q92769 +HDAC3 UP HDAC3_HUMAN O15379 +HDACi CHEBI EC 3.5.1.98 (histone deacetylase) inhibitor CHEBI:61115 +HDL FPLX 000225 HDL +HDM2 UP MDM2_HUMAN Q00987 +Heat Shock Protein 70 FPLX 000244 HSPA +heat shock protein family B FPLX 000245 HSPB +Hedgehog family FPLX 000226 Hedgehog +hedgehog protein FPLX 000226 Hedgehog +hedgehog signaling proteins FPLX 000226 Hedgehog +Hedgehog FPLX 000226 Hedgehog +heme oxygenase FPLX 000240 HMOX +hemoglobin FPLX 000227 Hemoglobin +HER-2 UP ERBB2_HUMAN P04626 +HER2 receptor UP ERBB2_HUMAN P04626 +HER2 UP ERBB2_HUMAN P04626 +HER3 UP ERBB3_HUMAN P21860 +Hes gene family FPLX 000228 HES +Hes genes FPLX 000228 HES +HES FPLX 000228 HES +Hes FPLX 000228 HES +HG HMDB HMDB00122 . +HGF UP HGF_HUMAN P14210 +Hic-5 UP TGFI1_HUMAN O43294 +HIF FPLX 000229 HIF +HIF-1 FPLX 000230 HIF1 +HIF-1alpha protein UP HIF1A_HUMAN Q16665 +HIF-1alpha UP HIF1A_HUMAN Q16665 +HIF-1α protein UP HIF1A_HUMAN Q16665 +HIF-1α UP HIF1A_HUMAN Q16665 +HIF1alpha protein UP HIF1A_HUMAN Q16665 +HIF1alpha UP HIF1A_HUMAN Q16665 +HIF1α protein UP HIF1A_HUMAN Q16665 +HIF1α UP HIF1A_HUMAN Q16665 +HIFalpha FPLX 000231 HIF_alpha +Hifalpha FPLX 000231 HIF_alpha +HIFbeta FPLX 000232 HIF_beta +Hifbeta FPLX 000232 HIF_beta +HIFs FPLX 000229 HIF +HIFα FPLX 000231 HIF_alpha +Hifα FPLX 000231 HIF_alpha +HIFβ FPLX 000232 HIF_beta +Hifβ FPLX 000232 HIF_beta +High-density lipoproteins FPLX 000225 HDL +HIPK2 UP HIPK2_HUMAN Q9H2X6 +Histone 2A FPLX 000235 Histone_H2A +histone deacetylase FPLX 000220 HDAC +histone deacetylases FPLX 000220 HDAC +histone H1 FPLX 000234 Histone_H1 +Histone H2A FPLX 000235 Histone_H2A +histone H2A FPLX 000235 Histone_H2A +histone H2B FPLX 000236 Histone_H2B +histone H3 FPLX 000237 Histone_H3 +histone H4 FPLX 000238 Histone_H4 +Histone FPLX 000233 Histone +histone FPLX 000233 Histone +histone-3 FPLX 000237 Histone_H3 +histones FPLX 000233 Histone +HLA-DR FPLX 000239 HLA_DR +HMGB1 UP HMGB1_HUMAN P09429 +HO-1 UP HMOX1_HUMAN P09601 +homeodomain iroquois proteins FPLX 000265 IRX +HOTAIR HGNC 33510 HOTAIR +HOTAIR NONCODE NONHSAT028507.2 . +HOTAIR LNCRNADB HOTAIR . +HR GO recombinational repair GO:0000725 +HR MESH Recombinational DNA Repair D059767 +HRAS UP RASH_HUMAN P01112 +HRASV12 UP RASH_HUMAN P01112 +HSF1 UP HSF1_HUMAN Q00613 +HSP20 UP HSPB6_HUMAN O14558 +HSP27 UP HSPB1_HUMAN P04792 +HSP70 FPLX 000244 HSPA +Hsp70 FPLX 000244 HSPA +HSP90 FPLX 000241 HSP90 +Hsp90 FPLX 000241 HSP90 +HSP90A FPLX 000242 HSP90A +HSP90AA FPLX 000243 HSP90AA +HSPB proteins FPLX 000245 HSPB +HSPB FPLX 000245 HSPB +hTERT UP TERT_HUMAN O14746 +HuR HGNC 3312 ELAVL1 +HuR UP ELAV1_HUMAN Q15717 +hydrogen peroxide PUBCHEM 784 . +hydrogen peroxide CHEBI hydrogen peroxide CHEBI:16240 +hypoxia-inducible factors FPLX 000229 HIF +I/R MESH Radiation, Ionizing D011839 +ICAM-1 UP ICAM1_HUMAN P05362 +IER3 UP IEX1_HUMAN P46695 +IFI16 UP IF16_HUMAN Q16666 +IFN FPLX 000262 Interferon +IFN-a FPLX 000246 IFNA +IFN-alpha FPLX 000246 IFNA +IFN-beta FPLX 000247 IFNB +IFN-beta UP IFNB_HUMAN P01574 +IFN-gamma UP IFNG_HUMAN P01579 +IFN-α FPLX 000246 IFNA +IFN-β FPLX 000247 IFNB +IFN-β UP IFNB_HUMAN P01574 +IFN-γ UP IFNG_HUMAN P01579 +IFNalpha FPLX 000246 IFNA +IFNgamma UP IFNG_HUMAN P01579 +IFNGR FPLX 000263 Interferon_gamma_receptor +IFNα FPLX 000246 IFNA +IFNγ UP IFNG_HUMAN P01579 +IGF-1 UP IGF1_HUMAN P05019 +IGF-1R UP IGF1R_HUMAN P08069 +IGF-1Rbeta UP IGF1R_HUMAN P08069 +IGF-1Rβ UP IGF1R_HUMAN P08069 +IGF-BP FPLX 000248 IGFBP +IGF-I UP IGF1_HUMAN P05019 +IGF-IR UP IGF1R_HUMAN P08069 +IGF1 UP IGF1_HUMAN P05019 +IGF1R UP IGF1R_HUMAN P08069 +IGFBP FPLX 000248 IGFBP +IGFBPs FPLX 000248 IGFBP +IkappaB kinase FPLX 000251 IKK_family +IkappaB FPLX 000249 IKB +IkappaB-alpha HGNC 7797 NFKBIA +IkappaBalpha UP IKBA_HUMAN P25963 +IKK complex FPLX 000250 IKK_complex +IKK FPLX 000251 IKK_family +IKKalpha UP IKKA_HUMAN O15111 +IKKbeta UP IKKB_HUMAN O14920 +IKKβ UP IKKB_HUMAN O14920 +IKKα UP IKKA_HUMAN O15111 +IL-1 FPLX 000252 IL1 +IL-10 UP IL10_HUMAN P22301 +IL-12 FPLX 000253 IL12 +IL-15 receptor FPLX 000254 IL15R +IL-15R FPLX 000254 IL15R +IL-17 UP IL17_HUMAN Q16552 +IL-18 UP IL18_HUMAN Q14116 +IL-1beta UP IL1B_HUMAN P01584 +IL-1β UP IL1B_HUMAN P01584 +IL-2 receptor FPLX 000255 IL2R +IL-2 UP IL2_HUMAN P60568 +IL-2R FPLX 000255 IL2R +IL-4 UP IL4_HUMAN P05112 +IL-6 UP IL6_HUMAN P05231 +IL-8 UP IL8_HUMAN P10145 +IL1 family FPLX 000252 IL1 +IL12 FPLX 000253 IL12 +imatinib PUBCHEM 5291 . +imatinib LINCS 10023-103 . +imatinib CHEBI imatinib CHEBI:45783 +immune response GO immune response GO:0006955 +infiltration MESH Neoplasm Invasiveness D009361 +inflammation GO inflammatory response GO:0006954 +inflammation MESH Inflammation D007249 +inflammatory response GO inflammatory response GO:0006954 +inflammatory response MESH None 0007249 +inhibin A FPLX 000257 Inhibin_A +inhibin B FPLX 000258 Inhibin_B +Inhibin FPLX 000256 Inhibin +inhibin FPLX 000256 Inhibin +inhibin-A FPLX 000257 Inhibin_A +inhibin-a FPLX 000257 Inhibin_A +inhibin-B FPLX 000258 Inhibin_B +inhibin-b FPLX 000258 Inhibin_B +initiation factor 4E binding proteins FPLX 000154 EIF4EBP +iNOS UP NOS2_HUMAN P35228 +insulin family FPLX 000259 INS +Insulin receptor family FPLX 000260 INSR +insulin receptor family FPLX 000260 INSR +insulin receptor substrate FPLX 000264 IRS +insulin receptor UP INSR_HUMAN P06213 +insulin receptor/insulin-like growth factor receptor family FPLX 000260 INSR +Insulin UP INS_HUMAN P01308 +insulin UP INS_HUMAN P01308 +insulin-like growth factor binding proteins FPLX 000248 IGFBP +integrin FPLX 000261 Integrins +integrins FPLX 000261 Integrins +Interferon beta FPLX 000247 IFNB +interferon beta FPLX 000247 IFNB +interferon gamma receptor FPLX 000263 Interferon_gamma_receptor +interferon γ receptor FPLX 000263 Interferon_gamma_receptor +Interferon β FPLX 000247 IFNB +interferon β FPLX 000247 IFNB +interferon FPLX 000262 Interferon +interferon-gamma receptor FPLX 000263 Interferon_gamma_receptor +interferon-γ receptor FPLX 000263 Interferon_gamma_receptor +invasion MESH Neoplasm Invasiveness D009361 +invasiveness MESH Neoplasm Invasiveness D009361 +IQGAP1 UP IQGA1_HUMAN P46940 +IR MESH Radiation, Ionizing D011839 +IR UP INSR_HUMAN P06213 +IRF3 UP IRF3_HUMAN Q14653 +iron PUBCHEM 23925 . +iron CHEBI iron atom CHEBI:18248 +Iroquois family FPLX 000265 IRX +Iroquois proteins FPLX 000265 IRX +Iroquois-class homeodomain proteins FPLX 000265 IRX +IRS family FPLX 000264 IRS +IRS FPLX 000264 IRS +IRS-1 UP IRS1_HUMAN P35568 +IRS-2 UP IRS2_HUMAN Q9Y4H2 +IRS1 UP IRS1_HUMAN P35568 +IRS2 UP IRS2_HUMAN Q9Y4H2 +isoflurane PUBCHEM 3763 . +isoflurane CHEBI isoflurane CHEBI:6015 +IκB kinase FPLX 000251 IKK_family +IκB FPLX 000249 IKB +IκB-α HGNC 7797 NFKBIA +IκBα UP IKBA_HUMAN P25963 +JAK FPLX 000266 JAK +Jak FPLX 000266 JAK +JAK2 UP JAK2_HUMAN O60674 +JAKs FPLX 000266 JAK +JNK MAPK FPLX 000267 JNK +JNK FPLX 000267 JNK +JNK1 UP MK08_HUMAN P45983 +JNK1/2 FPLX 000267 JNK +JNKs FPLX 000267 JNK +JQ1 PUBCHEM 46907787 . +JQ1 CHEBI LSM-6332 CHEBI:95080 +JUN FPLX 000268 JUN_family +K-Ras UP RASK_HUMAN P01116 +Kainate receptors FPLX 000269 Kainate_family +kallikrein FPLX 000271 KLK +kallikrein-related peptidases FPLX 000271 KLK +KARs FPLX 000269 Kainate_family +Keap1 UP KEAP1_HUMAN Q14145 +kinetochore centromere binding factor 3 FPLX 000084 CBF3 +kinetochore complex FPLX 000270 Kinetochore +kinetochore FPLX 000270 Kinetochore +kinetochores FPLX 000270 Kinetochore +KLF5 UP KLF5_HUMAN Q13887 +Klf5 UP KLF5_HUMAN Q13887 +KLKs FPLX 000271 KLK +KRAS UP RASK_HUMAN P01116 +Kras UP RASK_HUMAN P01116 +KSR FPLX 000272 KSR +LA CHEBI (R)-lipoic acid CHEBI:30314 +LA PUBCHEM 6112 . +lactate PUBCHEM 91435 . +lactate CHEBI lactate CHEBI:24996 +laminin 332 chains FPLX 000274 Laminin_332 +laminin 332 FPLX 000274 Laminin_332 +laminin-332 chains FPLX 000274 Laminin_332 +laminin-332 FPLX 000274 Laminin_332 +Laminin-5 FPLX 000274 Laminin_332 +laminin-5 FPLX 000274 Laminin_332 +lapatinib PUBCHEM 208908 . +lapatinib CHEBI lapatinib CHEBI:49603 +LAT UP LAT_HUMAN O43561 +LC3 FPLX 000280 MAP1LC3 +Lck UP LCK_HUMAN P06239 +LDH FPLX 000275 LDH +lead PUBCHEM 5352425 . +lead CHEBI lead atom CHEBI:25016 +leptin UP LEP_HUMAN P41159 +LFA-1 (integrin) FPLX 000261 Integrins +LH FPLX 000276 LH +LIF UP LIF_HUMAN P15018 +lipopolysaccharide CHEBI lipopolysaccharide CHEBI:16412 +lipopolysaccharide MESH Lipopolysaccharides D008070 +LKB1 UP STK11_HUMAN Q15831 +LM-1 FPLX 000273 Laminin_111 +LMP1 UP LMP1_EBVB9 P03230 +localization GO localization GO:0051179 +long-chain acyl-CoA synthetase FPLX 000008 ACSL +LPA UP APOA_HUMAN P08519 +LPS CHEBI lipopolysaccharide CHEBI:16412 +LPS MESH Lipopolysaccharides D008070 +LRRK2 UP LRRK2_HUMAN Q5S007 +Luteinizing hormone FPLX 000276 LH +luteinizing hormone FPLX 000276 LH +luteinizing-hormone FPLX 000276 LH +luteolin PUBCHEM 5280445 . +luteolin CHEBI luteolin CHEBI:15864 +MA PUBCHEM 10836 . +MA CHEBI methamphetamine CHEBI:6809 +MA PUBCHEM 73659 . +MA CHEBI maslinic acid CHEBI:66682 +MA UP GAG_HV1H2 P04591 +MAC FPLX 000278 MAC +MAC-1 (integrin) FPLX 000261 Integrins +Mad2 UP MD2L1_HUMAN Q13257 +Maf subfamily FPLX 000279 MAF +MAF FPLX 000279 MAF +Maf FPLX 000279 MAF +maf FPLX 000279 MAF +MAF UP MAF_HUMAN O75444 +Maf UP MAF_HUMAN O75444 +maf UP MAF_HUMAN O75444 +mammalian target of rapamycin UP MTOR_HUMAN P42345 +mangiferin CHEBI mangiferin CHEBI:6682 +mangiferin PUBCHEM 5281647 . +MAP kinase FPLX 000283 MAPK +MAP kinases FPLX 000283 MAPK +MAP2K1 UP MP2K1_HUMAN Q02750 +MAP2K2 UP MP2K2_HUMAN P36507 +MAP3K FPLX 000282 MAP3K +MAP3K2 UP M3K2_HUMAN Q9Y2U5 +MAPK kinase kinase FPLX 000282 MAP3K +MAPK kinase FPLX 000281 MAP2K +MAPK p38 FPLX 000326 p38 +MAPK FPLX 000161 ERK +MAPK1 UP MK01_HUMAN P28482 +MAPK3 UP MK03_HUMAN P27361 +MAPKK kinases FPLX 000282 MAP3K +MAPKKK FPLX 000282 MAP3K +MAPKs FPLX 000283 MAPK +MAZ UP MAZ_HUMAN P56270 +Mcl-1 UP MCL1_HUMAN Q07820 +MCM FPLX 000284 MCM +MCP-1 UP None P0CW71 +MDM2 UP MDM2_HUMAN Q00987 +Mdm2 UP MDM2_HUMAN Q00987 +MDMX UP MDM4_HUMAN O15151 +Mdmx UP MDM4_HUMAN O15151 +MED14 UP MED14_HUMAN O60244 +MED23 UP MED23_HUMAN Q9ULK4 +MEF2 family FPLX 000285 MEF2 +MEF2 FPLX 000285 MEF2 +MEF2C UP MEF2C_HUMAN Q06413 +MEK 1/2 FPLX 000286 MEK +MEK inhibitor CHEBI EC 2.7.12.2 (mitogen-activated protein kinase kinase) inhibitor CHEBI:88286 +MEK inhibitors CHEBI EC 2.7.12.2 (mitogen-activated protein kinase kinase) inhibitor CHEBI:88286 +MEK FPLX 000286 MEK +MEK1 UP MP2K1_HUMAN Q02750 +MEK1/2 FPLX 000286 MEK +melanin PUBCHEM 6325610 . +melanin CHEBI Melanin CHEBI:89634 +melatonin CHEBI melatonin CHEBI:16796 +melatonin PUBCHEM 896 . +membrane attack complex FPLX 000278 MAC +membrane attack FPLX 000278 MAC +MET UP MET_HUMAN P08581 +Met UP MET_HUMAN P08581 +metabolism GO metabolic process GO:0008152 +metabolism MESH Metabolism D008660 +metabotrophic glutamate receptor FPLX 000193 GRM +metabotropic glutamate receptor FPLX 000193 GRM +metastasis MESH Neoplasm Metastasis D009362 +Metformin PUBCHEM 4091 . +Metformin CHEBI metformin CHEBI:6801 +metformin PUBCHEM 4091 . +metformin CHEBI metformin CHEBI:6801 +Metallothionein FPLX 000292 Metallothionein +metallothionein FPLX 000292 Metallothionein +MG132 PUBCHEM 462382 . +MG132 CHEBI N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal CHEBI:75142 +mGluRs FPLX 000193 GRM +MIF UP MIF_HUMAN P14174 +mini-chromosome maintenance complex FPLX 000284 MCM +minichromosome maintenance complex FPLX 000284 MCM +minichromosome maintenance protein complex FPLX 000284 MCM +miR-101 MESH MIRN101 microRNA, human C534072 +miR-101 MIRBASE hsa-mir-101-1 MI0000103 +miR-101 HGNC 31488 MIR101-1 +miR-145 MIRBASE hsa-mir-145 MI0000461 +miR-145 HGNC 31532 MIR145 +miR-155 MIRBASE hsa-mir-155 MI0000681 +miR-155 HGNC 31542 MIR155 +miR-21 MIRBASE hsa-mir-21 MI0000077 +miR-21 HGNC 31586 MIR21 +miR-7 MIRBASE hsa-mir-7-1 MI0000263 +miR-7 HGNC 31638 MIR7-1 +MITF UP MITF_HUMAN O75030 +mammalian mitochondrial ribosome FPLX 000288 Mitochondrial_Ribosome +Mitochondrial ribosome FPLX 000288 Mitochondrial_Ribosome +Mitochondrial Ribosome FPLX 000288 Mitochondrial_Ribosome +mitochondrial ribosomes FPLX 000288 Mitochondrial_Ribosome +Mitochondrial ribosomes FPLX 000288 Mitochondrial_Ribosome +Mitochondrial Ribosomes FPLX 000288 Mitochondrial_Ribosome +mitoribosome FPLX 000288 Mitochondrial_Ribosome +Mitoribosome FPLX 000288 Mitochondrial_Ribosome +55S mammalian mitochondrial ribosome FPLX 000288 Mitochondrial_Ribosome +55S mitoribosome FPLX 000288 Mitochondrial_Ribosome +55s mitoribosome FPLX 000288 Mitochondrial_Ribosome +55S Mitoribosome FPLX 000288 Mitochondrial_Ribosome +55s Mitoribosome FPLX 000288 Mitochondrial_Ribosome +small mitoribosomal subunit FPLX 000289 MRPS +Small Mitoribosomal Subunit FPLX 000289 MRPS +small subunit of the mammalian mitochondrial ribosome FPLX 000289 MRPS +mitochondrial ribosomal small subunit FPLX 000289 MRPS +large mitoribosomal subunit FPLX 000290 MRPL +Large Mitoribosomal Subunit FPLX 000290 MRPL +large subunit of the mammalian mitochondrial ribosome FPLX 000290 MRPL +MGAT FPLX 000287 MGAT +mitochondrial ribosomal large subunit FPLX 000290 MRPL +mitochondrial membrane potential MESH Membrane Potential, Mitochondrial D053078 +mitogen activated protein kinase FPLX 000283 MAPK +mitogen activated protein kinases FPLX 000283 MAPK +mitogen-activated protein kinase kinase FPLX 000281 MAP2K +mitogen-activated protein kinase FPLX 000283 MAPK +mitogen-activated protein kinases FPLX 000283 MAPK +Miz1 UP ZBT17_HUMAN Q13105 +MKK4 UP MP2K4_HUMAN P45985 +MKP-1 UP DUS1_HUMAN P28562 +MKP3 UP DUS6_HUMAN Q16828 +MLC FPLX 000296 MYL +MM MESH Multiple Myeloma D009101 +MMC PUBCHEM 5746 . +MMC CHEBI mitomycin C CHEBI:27504 +MMP FPLX 000291 MMP +MMP-2 UP MMP2_HUMAN P08253 +MMP-9 UP MMP9_HUMAN P14780 +MMP9 UP MMP9_HUMAN P14780 +MMPs FPLX 000291 MMP +Mn CHEBI manganese(2+) CHEBI:29035 +Mn PUBCHEM 27854 . +MST1 UP STK4_HUMAN Q13043 +MST2 UP STK3_HUMAN Q13188 +MT FPLX 000292 Metallothionein +mTOR inhibitor CHEBI mTOR inhibitor CHEBI:68481 +mTOR inhibitors CHEBI mTOR inhibitor CHEBI:68481 +mTOR UP MTOR_HUMAN P42345 +mTORC1 FPLX 000293 mTORC1 +mTORC2 FPLX 000294 mTORC2 +MTX UP MTX1_HUMAN Q13505 +Mu-A PUBCHEM 375150 . +MUC1 UP MUC1_HUMAN P15941 +mutp53 UP P53_HUMAN P04637 +MYC UP MYC_HUMAN P01106 +Myc UP MYC_HUMAN P01106 +MYCN UP MYCN_HUMAN P04198 +myosin alkali light chain proteins FPLX 000297 MYL_alkali +myosin alkali light chain FPLX 000297 MYL_alkali +myosin heavy chain genes FPLX 000295 MYH +myosin heavy chain isoforms FPLX 000295 MYH +myosin heavy chain protein FPLX 000295 MYH +Myosin heavy chain FPLX 000295 MYH +myosin heavy chain FPLX 000295 MYH +Myosin heavy chains FPLX 000295 MYH +myosin heavy chains FPLX 000295 MYH +myosin light chain protein FPLX 000296 MYL +myosin light chain FPLX 000296 MYL +myosin light chains FPLX 000296 MYL +MYPT1 UP MYPT1_HUMAN O14974 +MYST family FPLX 000300 MYST +MYST histone acetylase FPLX 000300 MYST +MYST proteins FPLX 000300 MYST +N-cadherin UP CADH2_HUMAN P19022 +N-myc downstream regulated gene family FPLX 000307 NDRG +N-Myc UP MYCN_HUMAN P04198 +N-Ras UP RASN_HUMAN P01111 +Na+/K+-exchanging ATPase FPLX 000303 Na_K_ATPase +Na+/K+ATPase FPLX 000303 Na_K_ATPase +Na/K ATPase alpha FPLX 000057 ATP1A +Na/K ATPase α FPLX 000057 ATP1A +Na/K-ATPase FPLX 000303 Na_K_ATPase +NAC PUBCHEM 443227 . +NAC CHEBI NAC CHEBI:7421 +nAChR FPLX 000103 CHRN +NAD(P)H oxidase FPLX 000302 NADPH_oxidase +NAD(P)H-oxidase FPLX 000302 NADPH_oxidase +NADH dehydrogenase (ubiquinone) FPLX 000301 NADH_dehydrogenase +NADH dehydrogenase FPLX 000301 NADH_dehydrogenase +NADPH oxidase FPLX 000302 NADPH_oxidase +NADPH PUBCHEM 5884 . +NADPH CHEBI NADPH CHEBI:16474 +NADPH HMDB HMDB00221 . +naked cuticle FPLX 000315 NKD +NAP UP BASP1_HUMAN P80723 +Natriuretic Peptide FPLX 000304 Natriuretic_peptide +Natriuretic peptide FPLX 000304 Natriuretic_peptide +natriuretic peptide FPLX 000304 Natriuretic_peptide +Natriuretic Peptides FPLX 000304 Natriuretic_peptide +Natriuretic peptides FPLX 000304 Natriuretic_peptide +natriuretic peptides FPLX 000304 Natriuretic_peptide +NDR family FPLX 000307 NDRG +NDR-family FPLX 000307 NDRG +NDRG2 UP NDRG2_HUMAN Q9UN36 +necroptosis GO necroptotic process GO:0070266 +necrosis GO necrotic cell death GO:0070265 +necrosis MESH Necrosis D009336 +Nef UP NEF_HV1BR P03406 +NEMO UP NEMO_HUMAN Q9Y6K9 +neovascularization GO angiogenesis GO:0001525 +neovascularization MESH Neovascularization, Physiologic D018919 +Net1 UP ARHG8_HUMAN Q7Z628 +neuregulin family FPLX 000318 NRG +Neuregulin FPLX 000318 NRG +neuregulin FPLX 000318 NRG +Neuregulins FPLX 000318 NRG +neuregulins FPLX 000318 NRG +Neurexins FPLX 000308 Neurexins +NF-E2 FPLX 000310 NFE +NF-E2-related factor FPLX 000310 NFE +NF-kappaB Class 1 FPLX 000312 NFkappaB_1 +NF-kappaB class 1 FPLX 000312 NFkappaB_1 +NF-kappaB Class 2 FPLX 000313 NFkappaB_2 +NF-kappaB class 2 FPLX 000313 NFkappaB_2 +NF-kappaB Class I FPLX 000312 NFkappaB_1 +NF-kappaB class I FPLX 000312 NFkappaB_1 +NF-kappaB Class II FPLX 000313 NFkappaB_2 +NF-kappaB class II FPLX 000313 NFkappaB_2 +NF-kappaB complexes FPLX 000311 NFkappaB +NF-kappaB dimers FPLX 000311 NFkappaB +NF-kappaB Factors FPLX 000311 NFkappaB +NF-kappaB factors FPLX 000311 NFkappaB +NF-kappaB genes FPLX 000311 NFkappaB +NF-kappaB p50 HGNC 7794 NFKB1 +NF-kappaB p65 HGNC 9955 RELA +NF-kappaB p65 UP TF65_HUMAN Q04206 +NF-kappaB subunits FPLX 000311 NFkappaB +NF-kappaB TFs FPLX 000311 NFkappaB +NF-kappaB FPLX 000311 NFkappaB +NF-kappaB1 HGNC 7794 NFKB1 +NF-kappaB2 HGNC 7795 NFKB2 +NF-kappabeta FPLX 000311 NFkappaB +NF-kappaBp50 HGNC 7794 NFKB1 +NF-kappaBp65 HGNC 9955 RELA +NF-kappaBs FPLX 000311 NFkappaB +NF-kB FPLX 000311 NFkappaB +NF-Y FPLX 000314 NFY +NF-κB Class 1 FPLX 000312 NFkappaB_1 +NF-κB class 1 FPLX 000312 NFkappaB_1 +NF-κB Class 2 FPLX 000313 NFkappaB_2 +NF-κB class 2 FPLX 000313 NFkappaB_2 +NF-κB Class I FPLX 000312 NFkappaB_1 +NF-κB class I FPLX 000312 NFkappaB_1 +NF-κB Class II FPLX 000313 NFkappaB_2 +NF-κB class II FPLX 000313 NFkappaB_2 +NF-κB complexes FPLX 000311 NFkappaB +NF-κB dimers FPLX 000311 NFkappaB +NF-κB Factors FPLX 000311 NFkappaB +NF-κB factors FPLX 000311 NFkappaB +NF-κB genes FPLX 000311 NFkappaB +NF-κB p50 HGNC 7794 NFKB1 +NF-κB p65 HGNC 9955 RELA +NF-κB p65 UP TF65_HUMAN Q04206 +NF-κB subunits FPLX 000311 NFkappaB +NF-κB TFs FPLX 000311 NFkappaB +NF-κB FPLX 000311 NFkappaB +NF-κB1 HGNC 7794 NFKB1 +NF-κB2 HGNC 7795 NFKB2 +NF-κBp50 HGNC 7794 NFKB1 +NF-κBp65 HGNC 9955 RELA +NF-κBs FPLX 000311 NFkappaB +NF-κβ FPLX 000311 NFkappaB +NFAT FPLX 000309 NFAT +NFkappaB complexes FPLX 000311 NFkappaB +NFkappaB p50 HGNC 7794 NFKB1 +NFkappaB p65 HGNC 9955 RELA +NFkappaB FPLX 000311 NFkappaB +NFkappaBp65 HGNC 9955 RELA +NFY FPLX 000314 NFY +NFκB complexes FPLX 000311 NFkappaB +NFκB p50 HGNC 7794 NFKB1 +NFκB p65 HGNC 9955 RELA +NFκB FPLX 000311 NFkappaB +NFκBp65 HGNC 9955 RELA +NGF UP NGF_HUMAN P01138 +nicotine class acetylcholine receptors FPLX 000103 CHRN +nicotinic acetylcholine receptor FPLX 000103 CHRN +nitric oxide PUBCHEM 145068 . +nitric oxide CHEBI nitric oxide CHEBI:16480 +nmMLCK UP MYLK_HUMAN Q15746-1 +nmMLCK1 UP MYLK_HUMAN Q15746-1 +NO HMDB HMDB03378 . +NO CHEBI nitric oxide CHEBI:16480 +NO PUBCHEM 145068 . +non-ELR-CXC chemokines FPLX 000128 CXCL_ELR_negative +NOS FPLX 000316 NOS +Notch FPLX 000317 Notch +Notch1 UP NOTC1_HUMAN P46531 +NOX1 UP NOX1_HUMAN Q9Y5S8 +NOX2 UP CY24B_HUMAN P04839 +NOX3 UP NOX3_HUMAN Q9HBY0 +NOX4 UP NOX4_HUMAN Q9NPH5 +Noxa UP APR_HUMAN Q13794 +NPM UP NPM_HUMAN P06748 +NRAS UP RASN_HUMAN P01111 +NRF2 UP NF2L2_HUMAN Q16236 +Nrf2 UP NF2L2_HUMAN Q16236 +NRG1 UP NRG1_HUMAN Q02297 +NRG1-NRG2 FPLX 000319 NRG_1_2 +NRG1/2 FPLX 000319 NRG_1_2 +NRG3-NRG4 FPLX 000320 NRG_3_4 +NRG3/4 FPLX 000320 NRG_3_4 +NRGs FPLX 000318 NRG +NRXN FPLX 000308 Neurexins +NTF3 UP NTF3_HUMAN P20783 +NTRK FPLX 000321 NTRK +NTRKs FPLX 000321 NTRK +Nuclear factor erythroid 2-related factor FPLX 000310 NFE +nuclear factor Y FPLX 000314 NFY +nuclear factor-Y FPLX 000314 NFY +Nuclear Receptor Co-Repressor FPLX 000306 NCOR +nuclear receptor co-repressor FPLX 000306 NCOR +Nuclear receptor corepressor FPLX 000306 NCOR +nuclear receptor corepressor FPLX 000306 NCOR +Nutlin-3 PUBCHEM 16755649 . +Nutlin-3 CHEBI Nutlin-3 CHEBI:46742 +NVP-BEZ235 PUBCHEM 11977753 . +NVP-BEZ235 LINCS 10232-101 . +NVP-BEZ235 CHEBI dactolisib CHEBI:71952 +NVP-LDE-225 PUBCHEM 24775005 . +NVP-LDE-225 CHEBI sonidegib CHEBI:90863 +OA CHEBI oleanolic acid CHEBI:37659 +OA PUBCHEM 10494 . +OA CHEBI okadaic acid CHEBI:44658 +OA PUBCHEM 446512 . +ofalpha(2)-adrenoceptor FPLX 000020 ADRA2 +ofα(2)-adrenoceptor FPLX 000020 ADRA2 +OPG UP TR11B_HUMAN O00300 +OPN UP OSTP_HUMAN P10451 +ov-serpins FPLX 000431 SERPINB +oxaliplatin CHEBI oxaliplatin CHEBI:31941 +oxaliplatin PUBCHEM 6857599 . +oxygen HMDB HMDB01377 . +oxygen CHEBI dioxygen CHEBI:15379 +oxygen PUBCHEM 977 . +P-REX1 UP PREX1_HUMAN Q8TCU6 +p100 HGNC 7795 NFKB2 +p105 HGNC 7794 NFKB1 +p110 FPLX 000359 PI3K_p110 +p110alpha UP PK3CA_HUMAN P42336 +p110beta UP PK3CB_HUMAN P42338 +p110α UP PK3CA_HUMAN P42336 +p110β UP PK3CB_HUMAN P42338 +p120 UP CTND1_HUMAN O60716 +p130 UP BCAR1_HUMAN P56945 +p16 UP CDN2A_HUMAN P42771 +p160/SRC FPLX 000305 NCOA +p21 Cip1 UP CDN1A_HUMAN P38936 +p21 WAF1 UP CDN1A_HUMAN P38936 +p21 UP CDN1A_HUMAN P38936 +p22 phox UP CY24A_HUMAN P13498 +p27 Kip1 UP CDN1B_HUMAN P46527 +p27 UP CDN1B_HUMAN P46527 +P2X purinoreceptor FPLX 000324 P2RX +P2X purinoreceptors FPLX 000324 P2RX +P2X receptor FPLX 000324 P2RX +P2X receptors FPLX 000324 P2RX +P2X FPLX 000324 P2RX +P2Y receptor FPLX 000325 P2RY +p300 UP EP300_HUMAN Q09472 +P38 MAPK FPLX 000326 p38 +p38 MAPK FPLX 000326 p38 +p38 MAPKs FPLX 000326 p38 +p38 FPLX 000326 p38 +p38-MAPK FPLX 000326 p38 +p38MAPK FPLX 000326 p38 +p40 phox UP NCF4_HUMAN Q15080 +p42 UP MK01_HUMAN P28482 +p42 UP PA2G4_HUMAN Q9UQ80 +p47 phox UP NCF1_HUMAN P14598 +p50 UP NFKB1_HUMAN P19838 +p52 HGNC 7795 NFKB2 +P53 family FPLX 000327 p53_family +p53 Family FPLX 000327 p53_family +p53 family FPLX 000327 p53_family +P53 UP P53_HUMAN P04637 +p53 UP P53_HUMAN P04637 +p53/p63/p73 family FPLX 000327 p53_family +p62 UP SQSTM_HUMAN Q13501 +p63 UP P63_HUMAN Q9H3D4 +p65 UP TF65_HUMAN Q04206 +p66Shc UP SHC1_HUMAN P29353-1 +p67 phox UP NCF2_HUMAN P19878 +p70 S6 kinase FPLX 000328 P70S6K +p70 UP KS6B1_HUMAN P23443 +P70RSK FPLX 000328 P70S6K +p70RSK FPLX 000328 P70S6K +p70S6 kinase UP KS6B1_HUMAN P23443 +P70S6K FPLX 000328 P70S6K +p70S6K UP KS6B1_HUMAN P23443 +p73 UP P73_HUMAN O15350 +p85 FPLX 000360 PI3K_p85 +p85alpha UP P85A_HUMAN P27986 +p85α UP P85A_HUMAN P27986 +p90RSK FPLX 000329 P90RSK +PA CHEBI phosphatidic acid CHEBI:16337 +PA PUBCHEM 8144759 . +paeoniflorin CHEBI paeoniflorin CHEBI:7889 +paeoniflorin PUBCHEM 442534 . +PAI-1 UP PAI1_HUMAN P05121 +PAK FPLX 000330 PAK +Pak FPLX 000330 PAK +PAK1 UP PAK1_HUMAN Q13153 +Pak1 UP PAK1_HUMAN Q13153 +Pak2 UP PAK2_HUMAN Q13177 +PAK4 UP PAK4_HUMAN O96013 +palmitate PUBCHEM 985 . +palmitate CHEBI hexadecanoic acid CHEBI:15756 +palmitate HMDB HMDB00220 . +PAR3 UP PARD3_HUMAN Q8TEW0 +Parkin UP PRKN_HUMAN O60260 +PARP genes FPLX 000331 PARP +PARP UP PARP1_HUMAN P09874 +Parp UP PARP1_HUMAN P09874 +PARP-1 UP PARP1_HUMAN P09874 +PARPs FPLX 000331 PARP +Parvin FPLX 000332 PARV +parvin FPLX 000332 PARV +Parvins FPLX 000332 PARV +parvins FPLX 000332 PARV +PATCHED FPLX 000333 Patched +Patched FPLX 000333 Patched +paxillin UP PAXI_HUMAN P49023 +PBX FPLX 000334 PBX +Pbx FPLX 000334 PBX +pbx FPLX 000334 PBX +PBXs FPLX 000334 PBX +Pca MESH Prostatic Neoplasms D011471 +PCNA UP PCNA_HUMAN P12004 +PD MESH Parkinson Disease D010300 +PD-1 HGNC 8760 PDCD1 +PD98509 CHEBI EC 2.7.11.24 (mitogen-activated protein kinase) inhibitor CHEBI:79091 +PDE 2 HGNC 8777 PDE2A +PDE 3 FPLX 000337 PDE3 +PDE FPLX 000335 PDE +PDE1 family FPLX 000336 PDE1 +PDE1 FPLX 000336 PDE1 +PDE3 family FPLX 000337 PDE3 +PDE3 FPLX 000337 PDE3 +PDE4 family FPLX 000338 PDE4 +PDE4 isoforms FPLX 000338 PDE4 +PDE4 FPLX 000338 PDE4 +PDE5 HGNC 8784 PDE5A +PDE6 family FPLX 000339 PDE6 +PDE6 FPLX 000339 PDE6 +PDE7 FPLX 000340 PDE7 +PDE8 FPLX 000341 PDE8 +PDEs FPLX 000335 PDE +PDGF CC FPLX 000350 PDGF_CC +PDGF DD FPLX 000351 PDGF_DD +PDGF FPLX 000342 PDGF +PDGF-AA FPLX 000347 PDGF_AA +PDGF-aa FPLX 000347 PDGF_AA +PDGF-AB FPLX 000348 PDGF_AB +PDGF-ab FPLX 000348 PDGF_AB +PDGF-BB FPLX 000349 PDGF_BB +PDGF-bb FPLX 000349 PDGF_BB +PDGF-CC FPLX 000350 PDGF_CC +PDGF-cc FPLX 000350 PDGF_CC +PDGF-DD FPLX 000351 PDGF_DD +PDGF-dd FPLX 000351 PDGF_DD +PDGFAA FPLX 000347 PDGF_AA +PDGFAB FPLX 000348 PDGF_AB +PDGFBB FPLX 000349 PDGF_BB +PDGFR FPLX 000343 PDGFR +PDGFR-AA FPLX 000344 PDGFR_AA +PDGFR-AB FPLX 000345 PDGFR_AB +PDGFR-alphaalpha FPLX 000344 PDGFR_AA +PDGFR-alphabeta FPLX 000345 PDGFR_AB +PDGFR-BB FPLX 000346 PDGFR_BB +PDGFR-betabeta FPLX 000346 PDGFR_BB +PDGFR-αα FPLX 000344 PDGFR_AA +PDGFR-αβ FPLX 000345 PDGFR_AB +PDGFR-ββ FPLX 000346 PDGFR_BB +PDGFRalpha UP PGFRA_HUMAN P16234 +PDGFRalphaalpha FPLX 000344 PDGFR_AA +PDGFRalphabeta FPLX 000345 PDGFR_AB +PDGFRbeta UP PGFRB_HUMAN P09619 +PDGFRbetabeta FPLX 000346 PDGFR_BB +PDGFRβ UP PGFRB_HUMAN P09619 +PDGFRα UP PGFRA_HUMAN P16234 +PDGFRαα FPLX 000344 PDGFR_AA +PDGFRαβ FPLX 000345 PDGFR_AB +PDGFRββ FPLX 000346 PDGFR_BB +PDH FPLX 000352 PDH +PDK FPLX 000353 PDK +PDK UP PDPK1_HUMAN O15530 +PDK1 UP PDPK1_HUMAN O15530 +PDKs FPLX 000353 PDK +PDPK1 UP PDPK1_HUMAN O15530 +PDT MESH Photochemotherapy D010778 +PEA-15 UP PEA15_HUMAN Q15121 +PERK UP E2AK3_HUMAN Q9NZJ5 +Peroxiredoxin FPLX 000388 PRDX +peroxiredoxin FPLX 000388 PRDX +Peroxiredoxins FPLX 000388 PRDX +peroxiredoxins FPLX 000388 PRDX +Pertussis toxin FPLX 000354 Pertussis_toxin +pertussis toxin FPLX 000354 Pertussis_toxin +PF-3758309 PUBCHEM 25227462 . +PF-3758309 CHEBI N-[(1S)-2-(dimethylamino)-1-phenylethyl]-6,6-dimethyl-3-[(2-methyl-4-thieno[3,2-d]pyrimidinyl)amino]-1,4-dihydropyrrolo[3,4-c]pyrazole-5-carboxamide CHEBI:93751 +PGC-1alpha UP PRGC1_HUMAN Q9UBK2 +PGC-1α UP PRGC1_HUMAN Q9UBK2 +PGE 2 CHEBI prostaglandin E2-UM CHEBI:73965 +PGE 2 PUBCHEM 161468 . +PGE2 UP PE2R4_HUMAN P35408 +phenformin PUBCHEM 8249 . +phenformin CHEBI phenformin CHEBI:8064 +PhK FPLX 000356 PhK +phosphatase FPLX 000357 Phosphatase +phosphatidylinositol 3-kinase FPLX 000358 PI3K +phosphatidylinositol CHEBI phosphatidylinositol CHEBI:28874 +phosphatidylinositol MESH Phosphatidylinositols D010716 +phospho-ERK1/2 FPLX 000161 ERK +Phosphodiesterase 1 FPLX 000336 PDE1 +phosphodiesterase 1 FPLX 000336 PDE1 +Phosphodiesterase 2 HGNC 8777 PDE2A +phosphodiesterase 2 HGNC 8777 PDE2A +Phosphodiesterase 3 FPLX 000337 PDE3 +phosphodiesterase 3 FPLX 000337 PDE3 +Phosphodiesterase 4 FPLX 000338 PDE4 +phosphodiesterase 4 FPLX 000338 PDE4 +Phosphodiesterase 5 HGNC 8784 PDE5A +phosphodiesterase 5 HGNC 8784 PDE5A +Phosphodiesterase 6 FPLX 000339 PDE6 +phosphodiesterase 6 FPLX 000339 PDE6 +Phosphodiesterase 7 FPLX 000340 PDE7 +phosphodiesterase 7 FPLX 000340 PDE7 +Phosphodiesterase 8 FPLX 000341 PDE8 +phosphodiesterase 8 FPLX 000341 PDE8 +Phosphodiesterase FPLX 000335 PDE +phosphodiesterase FPLX 000335 PDE +Phosphodiesterase-1 FPLX 000336 PDE1 +phosphodiesterase-1 FPLX 000336 PDE1 +Phosphodiesterase-2 HGNC 8777 PDE2A +phosphodiesterase-2 HGNC 8777 PDE2A +Phosphodiesterase-3 FPLX 000337 PDE3 +phosphodiesterase-3 FPLX 000337 PDE3 +Phosphodiesterase-4 FPLX 000338 PDE4 +phosphodiesterase-4 FPLX 000338 PDE4 +Phosphodiesterase-5 HGNC 8784 PDE5A +phosphodiesterase-5 HGNC 8784 PDE5A +Phosphodiesterase-6 FPLX 000339 PDE6 +phosphodiesterase-6 FPLX 000339 PDE6 +Phosphodiesterase-7 FPLX 000340 PDE7 +phosphodiesterase-7 FPLX 000340 PDE7 +Phosphodiesterase-8 FPLX 000341 PDE8 +phosphodiesterase-8 FPLX 000341 PDE8 +Phosphodiesterases FPLX 000335 PDE +phosphodiesterases FPLX 000335 PDE +Phospholipase A2 Group IV FPLX 000368 PLA2G4 +phospholipase A2 group-II FPLX 000367 PLA2G2 +phospholipase A2 group-IV FPLX 000368 PLA2G4 +phospholipase A2 FPLX 000366 PLA2 +Phospholipase C FPLX 000369 PLC +phospholipase C FPLX 000369 PLC +Phospholipase C-beta FPLX 000370 PLCB +phospholipase C-beta FPLX 000370 PLCB +Phospholipase C-delta FPLX 000371 PLCD +phospholipase C-delta FPLX 000371 PLCD +Phospholipase C-β FPLX 000370 PLCB +phospholipase C-β FPLX 000370 PLCB +Phospholipase C-δ FPLX 000371 PLCD +phospholipase C-δ FPLX 000371 PLCD +Phospholipase Cbeta FPLX 000370 PLCB +phospholipase Cbeta FPLX 000370 PLCB +Phospholipase Cdelta FPLX 000371 PLCD +phospholipase Cdelta FPLX 000371 PLCD +Phospholipase Cβ FPLX 000370 PLCB +phospholipase Cβ FPLX 000370 PLCB +Phospholipase Cδ FPLX 000371 PLCD +phospholipase Cδ FPLX 000371 PLCD +Phospholipase D FPLX 000373 PLD +phospholipase D FPLX 000373 PLD +Phospholipase-C FPLX 000369 PLC +phospholipase-C FPLX 000369 PLC +Phosphorylase kinase FPLX 000356 PhK +phosphorylase kinase FPLX 000356 PhK +PI 3-kinase FPLX 000358 PI3K +PI 3-kinases FPLX 000358 PI3K +PI CHEBI phosphatidylinositol CHEBI:28874 +PI MESH Phosphatidylinositols D010716 +PI3-kinase FPLX 000358 PI3K +PI3K inhibitor CHEBI EC 2.7.1.127 (inositol-trisphosphate 3-kinase) inhibitor CHEBI:84801 +PI3K p110 subunit FPLX 000359 PI3K_p110 +PI3K FPLX 000358 PI3K +PI3Kinase FPLX 000358 PI3K +PIK3C FPLX 000359 PI3K_p110 +PIK3CA UP PK3CA_HUMAN P42336 +PIK3R FPLX 000361 PIK3R_I +PIM FPLX 000362 PIM +Pin1 UP PIN1_HUMAN Q13526 +PIP CHEBI phosphatidylinositol phosphate CHEBI:28765 +PIP3 MESH phosphatidylinositol 3,4,5-triphosphate C060974 +PIP3 CHEBI phosphatidylinositol trisphosphate CHEBI:60169 +PK-A FPLX 000363 PKA +PKA catalytic subunit FPLX 000389 PRKAC +PKA catalytic subunits FPLX 000389 PRKAC +PKA regulatory subunit FPLX 000390 PRKAR +PKA regulatory subunits FPLX 000390 PRKAR +PKA FPLX 000363 PKA +PKB FPLX 000023 AKT +PKB-Akt FPLX 000023 AKT +PKB/Akt FPLX 000023 AKT +PKC FPLX 000364 PKC +PKCalpha UP KPCA_HUMAN P17252 +PKCdelta UP KPCD_HUMAN Q05655 +PKCepsilon UP KPCE_HUMAN Q02156 +PKCα UP KPCA_HUMAN P17252 +PKCε UP KPCE_HUMAN Q02156 +PKCδ UP KPCD_HUMAN Q05655 +PKG FPLX 000391 PRKG +PKI FPLX 000365 PKI +PKM2 UP KPYM_HUMAN P14618 +PKR UP E2AK2_HUMAN P19525 +PLA2G2 FPLX 000367 PLA2G2 +PLA2g2 FPLX 000367 PLA2G2 +PLA2G4 FPLX 000368 PLA2G4 +PLB UP PPLA_HUMAN P26678 +PLC FPLX 000369 PLC +PLC-gamma FPLX 000372 PLCG +PLC-gamma1 UP PLCG1_HUMAN P19174 +PLC-γ FPLX 000372 PLCG +PLC-γ1 UP PLCG1_HUMAN P19174 +PLCgamma1 UP PLCG1_HUMAN P19174 +PLCγ1 UP PLCG1_HUMAN P19174 +PLK1 UP PLK1_HUMAN P53350 +Plk1 UP PLK1_HUMAN P53350 +PLX PUBCHEM 42611257 . +PLX CHEBI vemurafenib CHEBI:63637 +PLX4032 PUBCHEM 42611257 . +PLX4032 CHEBI vemurafenib CHEBI:63637 +PML UP PML_HUMAN P29590 +Pol delta FPLX 000141 DNA_polymerase_delta +pol delta FPLX 000141 DNA_polymerase_delta +Pol I FPLX 000416 RNApo_I +Pol δ FPLX 000141 DNA_polymerase_delta +pol δ FPLX 000141 DNA_polymerase_delta +Poly(ADP-ribose) polymerase FPLX 000331 PARP +Poly(ADP-ribose) polymerases FPLX 000331 PARP +polycomb Repressive Complex (PRC) 1 FPLX 000386 PRC1_complex +Polycomb Repressive Complex 1 FPLX 000386 PRC1_complex +Polycomb repressive complex 1 FPLX 000386 PRC1_complex +polycomb repressive complex 1 FPLX 000386 PRC1_complex +Polycomb Repressive Complex 2 FPLX 000387 PRC2_complex +Polycomb repressive complex 2 FPLX 000387 PRC2_complex +polycomb repressive complex 2 FPLX 000387 PRC2_complex +Polycomb repressive complex PRC1 FPLX 000386 PRC1_complex +Polycomb repressive complex PRC2 FPLX 000387 PRC2_complex +Polycomb Repressive Complexes 1 FPLX 000386 PRC1_complex +Polycomb Repressive Complexes 2 FPLX 000387 PRC2_complex +Polycomb-repressive complex 1 FPLX 000386 PRC1_complex +Polycomb-repressive complex 2 FPLX 000387 PRC2_complex +PP1 regulator FPLX 000376 PPP1 +PP1 FPLX 000376 PPP1 +PP1C FPLX 000377 PPP1C +PP1c FPLX 000377 PPP1C +PP1R FPLX 000378 PPP1R +PP1r FPLX 000378 PPP1R +PP2 phosphatases FPLX 000379 PPP2 +PP2 CHEBI PP2 CHEBI:78331 +PP2 PUBCHEM 4878 . +PP2 FPLX 000379 PPP2 +PP242 PUBCHEM 135565635 . +PP242 CHEBI torkinib CHEBI:90679 +PP2A catalytic C subunit FPLX 000380 PPP2C +PP2A regulatory subunit A FPLX 000381 PPP2R_A +PP2A regulatory subunit B FPLX 000382 PPP2R_B +PP2A FPLX 000379 PPP2 +PP2A-C FPLX 000380 PPP2C +PP2Ac FPLX 000380 PPP2C +PP2B catalytic subunit FPLX 000384 PPP3C +PP2B FPLX 000383 PPP3 +PPAR FPLX 000375 PPAR +PPAR-gamma UP PPARG_HUMAN P37231 +PPAR-γ UP PPARG_HUMAN P37231 +PPARgamma UP PPARG_HUMAN P37231 +PPARγ UP PPARG_HUMAN P37231 +PPP1 FPLX 000376 PPP1 +PPP1C FPLX 000377 PPP1C +PR UP PRGR_HUMAN P06401 +PRAS40 UP AKTS1_HUMAN Q96B36 +pRB UP RB_HUMAN P06400 +pRb UP RB_HUMAN P06400 +PRC1 FPLX 000386 PRC1_complex +PRC1 UP PRC1_HUMAN O43663 +PRC2 FPLX 000387 PRC2_complex +PRKAA FPLX 000044 AMPK_alpha +PRKAB FPLX 000045 AMPK_beta +PRKAG FPLX 000046 AMPK_gamma +PRL-3 UP TP4A3_HUMAN O75365 +Profilin FPLX 000355 PFN +profilin FPLX 000355 PFN +Profilins FPLX 000355 PFN +profilins FPLX 000355 PFN +progesterone CHEBI progesterone CHEBI:17026 +progesterone PUBCHEM 5994 . +Proliferation GO cell population proliferation GO:0008283 +Proliferation MESH Cell Proliferation D049109 +proliferation GO cell population proliferation GO:0008283 +proliferation MESH Cell Proliferation D049109 +Propionyl-CoA carboxylase FPLX 000392 Propionyl_CoA_carboxylase +propionyl-CoA carboxylase FPLX 000392 Propionyl_CoA_carboxylase +prostaglandin E receptor FPLX 000395 PTGER +protease FPLX 000393 Protease +proteasome endopeptidase FPLX 000394 Proteasome +proteasome FPLX 000394 Proteasome +protein farnesyltransferase FPLX 000172 FNT +Protein kinase A catalytic subunit FPLX 000389 PRKAC +protein kinase A catalytic subunit FPLX 000389 PRKAC +Protein kinase A catalytic subunits FPLX 000389 PRKAC +protein kinase A catalytic subunits FPLX 000389 PRKAC +Protein kinase A regulatory subunit FPLX 000390 PRKAR +protein kinase A regulatory subunit FPLX 000390 PRKAR +Protein kinase A regulatory subunits FPLX 000390 PRKAR +protein kinase A regulatory subunits FPLX 000390 PRKAR +protein kinase A FPLX 000363 PKA +protein kinase C FPLX 000364 PKC +protein kinase G FPLX 000391 PRKG +protein phosphatase 2 FPLX 000379 PPP2 +protein phosphatase 2B FPLX 000383 PPP3 +proteolysis GO proteolysis GO:0006508 +proteolysis MESH Proteolysis D059748 +PTC UP PTC_DROME P18502 +Ptc UP PTC_DROME P18502 +ptc UP PTC_DROME P18502 +PTEN UP PTEN_HUMAN P60484 +Pten UP PTEN_HUMAN P60484 +PTP1B UP PTN1_HUMAN P18031 +PTX FPLX 000354 Pertussis_toxin +PTX3 HGNC 9692 PTX3 +PTX3 UP PTX3_HUMAN P26022 +PUMA UP BBC3B_HUMAN Q96PG8 +PYG FPLX 000396 PYG +Pyk2 UP FAK2_HUMAN Q14289 +pyruvate dehydrogenase (acetyl-transferring) FPLX 000352 PDH +Pyruvate dehydrogenase kinase FPLX 000353 PDK +pyruvate dehydrogenase kinase FPLX 000353 PDK +quercetin CHEBI quercetin CHEBI:16243 +quercetin PUBCHEM 5280343 . +RA PUBCHEM 5538 . +RA CHEBI retinoic acid CHEBI:26536 +RA HMDB HMDB06219 . +Rab GTPase FPLX 000397 RAB +Rab GTPases FPLX 000397 RAB +rab GTPases FPLX 000397 RAB +rab proteins FPLX 000397 RAB +RAB FPLX 000397 RAB +Rab FPLX 000397 RAB +rab FPLX 000397 RAB +Rabs FPLX 000397 RAB +RAC FPLX 000398 RAC +Rac UP RAC1_HUMAN P63000 +RAC1 UP RAC1_HUMAN P63000 +Rac1 UP RAC1_HUMAN P63000 +RAD51 UP RAD51_HUMAN Q06609 +Rad51 UP RAD51_HUMAN Q06609 +Rad52 UP RAD52_HUMAN P43351 +RAF inhibitors CHEBI B-Raf inhibitor CHEBI:75047 +RAF FPLX 000399 RAF +Raf FPLX 000399 RAF +Raf-1 UP RAF1_HUMAN P04049 +RAGE UP RAGE_HUMAN Q15109 +RAL family FPLX 000400 RAL +Ral family FPLX 000400 RAL +RAL guanine nucleotide dissociation stimulator like FPLX 000413 RGL +Ral guanine nucleotide dissociation stimulator like FPLX 000413 RGL +ral guanine nucleotide dissociation stimulator like FPLX 000413 RGL +RAL isoforms FPLX 000400 RAL +Ral isoforms FPLX 000400 RAL +RAL proteins FPLX 000400 RAL +Ral proteins FPLX 000400 RAL +RAL FPLX 000400 RAL +RAL HGNC 9839 RALA +RalA UP RALA_HUMAN P11233 +RALGDS-like FPLX 000413 RGL +RANKL UP TNF11_HUMAN O14788 +Rap guanine nucleotide exchange factor FPLX 000402 RAPGEF +Rap guanine nucleotide exchange factors FPLX 000402 RAPGEF +Rap1 FPLX 000401 RAP1 +Rapamycin PUBCHEM 5284616 . +Rapamycin CHEBI sirolimus CHEBI:9168 +rapamycin PUBCHEM 5284616 . +rapamycin CHEBI sirolimus CHEBI:9168 +RapGEFs FPLX 000402 RAPGEF +Raptor UP RPTOR_HUMAN Q8N122 +raptor UP RPTOR_HUMAN Q8N122 +RAR FPLX 000403 RAR +RAS association domain family FPLX 000410 RASSF +Ras association domain family FPLX 000410 RASSF +Ras GTPase FPLX 000404 RAS +RAS FPLX 000404 RAS +Ras FPLX 000404 RAS +RAS-association domain family FPLX 000410 RASSF +Ras-association domain family FPLX 000410 RASSF +RASA FPLX 000405 RASA +RASAL FPLX 000406 RASAL +RasGAP FPLX 000407 RasGAP +RasGAPs FPLX 000407 RasGAP +RASGRF FPLX 000408 RASGRF +RASGRP FPLX 000409 RASGRP +RASSF family FPLX 000410 RASSF +RASSF1A UP RASF1_HUMAN Q9NS23 +RB UP RB_HUMAN P06400 +Rb UP RB_HUMAN P06400 +RB1 UP RB_HUMAN P06400 +Rb1 UP RB_HUMAN P06400 +receptor tyrosine kinase-like orphan receptor FPLX 000420 ROR +receptor tyrosine kinase-like orphan receptors FPLX 000420 ROR +REDD1 UP DDIT4_HUMAN Q9NX09 +regulatory A subunit of PP2A FPLX 000381 PPP2R_A +regulatory B subunit of PP2A FPLX 000382 PPP2R_B +regulatory family X FPLX 000412 RFX +regulatory myosin light chain FPLX 000298 MYL_regulatory +regulatory subunit of calcineurin FPLX 000385 PPP3R +RelA UP TF65_HUMAN Q04206 +replication factor C FPLX 000411 RFC +Replication protein A FPLX 000421 RPA +replication protein A FPLX 000421 RPA +RES PUBCHEM 5281611 . +Resveratrol PUBCHEM 445154 . +Resveratrol CHEBI resveratrol CHEBI:27881 +resveratrol PUBCHEM 445154 . +resveratrol CHEBI resveratrol CHEBI:27881 +RET UP RET_HUMAN P07949 +retinoblastoma protein UP RB_HUMAN P06400 +retinoic acid receptors FPLX 000403 RAR +retinoid X receptors FPLX 000424 RXR +retinoid-X receptor FPLX 000424 RXR +RF-C FPLX 000411 RFC +RF-X FPLX 000412 RFX +RFC FPLX 000411 RFC +RFX family FPLX 000412 RFX +RFX proteins FPLX 000412 RFX +RFX FPLX 000412 RFX +Rheb UP RHEB_HUMAN Q15382 +Rho family FPLX 000414 RHO +RHO FPLX 000414 RHO +Rho UP RHOA_HUMAN P61586 +Rho-GDI FPLX 000415 RhoGDI +RhoA UP RHOA_HUMAN P61586 +RhoB UP RHOB_HUMAN P62745 +RhoC UP RHOC_HUMAN P08134 +RHOGDI FPLX 000415 RhoGDI +RhoGDI FPLX 000415 RhoGDI +rhoGDI FPLX 000415 RhoGDI +RhoGDIs FPLX 000415 RhoGDI +ribosomal protein S6 UP RS6_HUMAN P62753 +ribosomal protein S6 IP IPR000529 . +RICTOR UP RICTR_HUMAN Q6R327 +Rictor UP RICTR_HUMAN Q6R327 +RIG-I UP DDX58_HUMAN O95786 +RIP1 UP RIPK1_HUMAN Q13546 +RKIP UP PEBP1_HUMAN P30086 +RNA polymerase 1 FPLX 000416 RNApo_I +RNA polymerase I FPLX 000416 RNApo_I +RNA polymerase II FPLX 000417 RNApo_II +RNAP II FPLX 000417 RNApo_II +ROCK FPLX 000419 ROCK +ROCK1 UP ROCK1_HUMAN Q13464 +ROCK2 UP ROCK2_HUMAN O75116 +ROR FPLX 000420 ROR +RORs FPLX 000420 ROR +ROS MESH Reactive Oxygen Species D017382 +ROS UP ROS1_HUMAN P08922 +rosiglitazone CHEBI rosiglitazone CHEBI:50122 +rosiglitazone PUBCHEM 77999 . +rottlerin CHEBI rottlerin CHEBI:8899 +rottlerin PUBCHEM 5281847 . +RPA FPLX 000421 RPA +rPKA FPLX 000390 PRKAR +RPS6KA FPLX 000329 P90RSK +RSK FPLX 000422 RSK +RSK2 UP KS6A3_HUMAN P51812 +RTA UP RFOX2_HUMAN O43251 +RTKs FPLX 000423 RTK +RUNX2 UP RUNX2_HUMAN Q13950 +rutin CHEBI rutin CHEBI:28527 +rutin PUBCHEM 5280805 . +RXR FPLX 000424 RXR +S100 FPLX 000425 S100 +S100A FPLX 000426 S100A +S100a FPLX 000426 S100A +S1P receptor FPLX 000427 S1PR +S1PR FPLX 000427 S1PR +S6 UP RS6_HUMAN P62753 +S6 IP IPR000529 . +S6K FPLX 000328 P70S6K +S6K1 UP KS6B1_HUMAN P23443 +SAA FPLX 000428 SAA +SAC GO meiotic spindle assembly checkpoint GO:0033316 +SAF-1 UP MAZ_HUMAN P56270 +SAHA PUBCHEM 5311 . +SAHA CHEBI vorinostat CHEBI:45716 +SAHA CHEMBL CHEMBL98 . +sarcoplasmic/endoplasmic reticulum calcium ATPase FPLX 000430 SERCA +SB203580 PUBCHEM 176155 . +SB203580 CHEBI SB 203580 CHEBI:90705 +SCF UP SCF_HUMAN P21583 +senescence GO cellular senescence GO:0090398 +senescence MESH Cellular Senescence D016922 +SERCA FPLX 000430 SERCA +SERCAs FPLX 000430 SERCA +SFK FPLX 000451 SRC +SFN CHEBI sulforaphane CHEBI:47807 +SFN PUBCHEM 5350 . +Shc family FPLX 000432 SHC +SHC FPLX 000432 SHC +Shc FPLX 000432 SHC +shikonin CHEBI Shikonin CHEBI:81068 +shikonin PUBCHEM 479503 . +SHP-2 UP PTN11_HUMAN Q06124 +SHP2 UP PTN11_HUMAN Q06124 +Shp2 UP PTN11_HUMAN Q06124 +Sialytransferase FPLX 000202 GTF_family_29 +Sialytransferases FPLX 000202 GTF_family_29 +sialytransferase FPLX 000202 GTF_family_29 +sialytransferases FPLX 000202 GTF_family_29 +signal transduction GO signal transduction GO:0007165 +signal transduction MESH Signal Transduction D015398 +simvastatin CHEBI simvastatin CHEBI:9150 +simvastatin PUBCHEM 54454 . +SIRT1 UP SIR1_HUMAN Q96EB6 +Sirt1 UP SIR1_HUMAN Q96EB6 +Skp2 UP SKP2_HUMAN Q13309 +SLC2 FPLX 000434 SLC2A +slow myosin FPLX 000299 MYL_slow +SLP-76 UP LCP2_HUMAN Q13094 +SLRP FPLX 000435 SLRP +SLRPs FPLX 000435 SLRP +SLRR FPLX 000435 SLRP +SLRRs FPLX 000435 SLRP +SMAD 2/3 FPLX 000443 SMAD2_3 +SMAD FPLX 000441 SMAD +Smad FPLX 000441 SMAD +smad FPLX 000441 SMAD +Smad2 UP SMAD2_HUMAN Q15796 +smad2 UP SMAD2_HUMAN Q15796 +SMAD2/3 FPLX 000443 SMAD2_3 +Smad2/3 FPLX 000443 SMAD2_3 +Smad3 UP SMAD3_HUMAN P84022 +Smad4 UP SMAD4_HUMAN Q13485 +small HSPs FPLX 000245 HSPB +small leucine rich proteoglycan family FPLX 000435 SLRP +small leucine rich proteoglycan FPLX 000435 SLRP +small leucine rich proteoglycans FPLX 000435 SLRP +small leucine-rich proteoglycan family FPLX 000435 SLRP +small leucine-rich proteoglycan FPLX 000435 SLRP +small leucine-rich proteoglycans FPLX 000435 SLRP +SMC1 FPLX 000444 SMC1 +Smc1 FPLX 000444 SMC1 +SNAI family FPLX 000446 SNAI +SNAI FPLX 000446 SNAI +Snail UP SNAI1_HUMAN O95863 +SOD FPLX 000447 SOD +Sorafenib PUBCHEM 216239 . +Sorafenib CHEBI sorafenib CHEBI:50924 +sorafenib PUBCHEM 216239 . +sorafenib CHEBI sorafenib CHEBI:50924 +SOS FPLX 000448 SOS +Sos-1 UP SOS1_HUMAN Q07889 +SOS1 UP SOS1_HUMAN Q07889 +Sos1 UP SOS1_HUMAN Q07889 +SOX2 UP SOX2_HUMAN P48431 +Sp1 UP SP1_HUMAN P08047 +SP600125 PUBCHEM 8515 . +SP600125 CHEBI anthra[1,9-cd]pyrazol-6(2H)-one CHEBI:90695 +SPC CHEBI sphingosine-1-phosphocholine CHEBI:17689 +SPC PUBCHEM 9847290 . +Sphingosine 1-phosphate receptor FPLX 000427 S1PR +sphingosine-1-phosphate receptors FPLX 000427 S1PR +SPRED FPLX 000449 SPRED +SPRY FPLX 000450 SPRY +SR Ca(2+)-ATPase FPLX 000430 SERCA +Src family kinase FPLX 000451 SRC +Src family FPLX 000451 SRC +src kinases FPLX 000451 SRC +SRC UP SRC_HUMAN P12931 +Src UP SRC_HUMAN P12931 +SRC-family kinases FPLX 000451 SRC +Src-kinases FPLX 000451 SRC +SREBF family FPLX 000452 SREBF +SREBF FPLX 000452 SREBF +SRF UP SRF_HUMAN P11831 +StAR HGNC 11359 STAR +StAR UP STAR_HUMAN P49675 +STAT FPLX 000453 STAT +STAT1 UP STAT1_HUMAN P42224 +STAT3 UP STAT3_HUMAN P40763 +Stat3 UP STAT3_HUMAN P40763 +STAT5 FPLX 000454 STAT5 +Stat5 FPLX 000454 STAT5 +STATs FPLX 000453 STAT +Staurosporine PUBCHEM 44259 . +Staurosporine CHEBI staurosporine CHEBI:15738 +staurosporine PUBCHEM 44259 . +staurosporine CHEBI staurosporine CHEBI:15738 +stearoyl-CoA 9-desaturase FPLX 000429 SCD +Stearoyl-CoA desaturase FPLX 000429 SCD +stearoyl-CoA desaturase FPLX 000429 SCD +sterol regulatory element binding protein FPLX 000452 SREBF +sterol regulatory element-binding factor FPLX 000452 SREBF +STING UP STING_HUMAN Q86WV6 +STT3 FPLX 000455 STT3 +STZ PUBCHEM 29327 . +STZ UP SIA4C_HUMAN Q11206 +succinate dehydrogenase (ubiquinone) FPLX 000502 ETC_complex_II +succinate dehydrogenase FPLX 000502 ETC_complex_II +Sulfonylurea Receptor FPLX 000456 Sulfonylurea_receptor +sulfonylurea receptor FPLX 000456 Sulfonylurea_receptor +sulfonylurea receptors FPLX 000456 Sulfonylurea_receptor +sulforaphane PUBCHEM 5350 . +sulforaphane CHEBI sulforaphane CHEBI:47807 +superoxide CHEBI superoxide CHEBI:18421 +superoxide PUBCHEM 5359597 . +SUR FPLX 000456 Sulfonylurea_receptor +Survivin UP BIRC5_HUMAN O15392 +survivin UP BIRC5_HUMAN O15392 +SWI and SNF complex FPLX 000457 SWI_SNF +SWI/SNF complex FPLX 000457 SWI_SNF +SWI/SNF FPLX 000457 SWI_SNF +SWI/SNF-like FPLX 000457 SWI_SNF +Syk UP KSYK_HUMAN P43405 +SYNJ2 UP SYNJ2_HUMAN O15056 +T-cell factor (TCF)/lymphoid enhancer factor FPLX 000460 TCF_LEF +TAK1 UP M3K7_HUMAN O43318 +TAK165 PUBCHEM 6444692 . +tamoxifen PUBCHEM 2733526 . +tamoxifen CHEBI tamoxifen CHEBI:41774 +TAP transporter FPLX 000459 TAP +TAP FPLX 000459 TAP +TAp73 UP P73_HUMAN O15350 +TAS-116 PUBCHEM 67501411 . +Tat UP TAT_HV1H2 P04608 +tau UP TAU_HUMAN P10636 +Tax UP TAX_HTL1A P03409 +TBK1 UP TBK1_HUMAN Q9UHD2 +TCF FPLX 000460 TCF_LEF +Tcf FPLX 000460 TCF_LEF +Tcf/Lef FPLX 000460 TCF_LEF +TCR FPLX 000461 TCR +TDRG1 UP TDRG1_HUMAN Q3Y452 +telomerase UP TERT_HUMAN O14746 +Temozolomide CHEBI temozolomide CHEBI:72564 +Temozolomide PUBCHEM 5394 . +temozolomide CHEBI temozolomide CHEBI:72564 +temozolomide PUBCHEM 5394 . +Tenascin FPLX 000473 TN +tenascin FPLX 000473 TN +TFDP FPLX 000464 TFDP +TFIIE FPLX 000196 GTF2E +TFIIF FPLX 000197 GTF2F +TGF beta receptor FPLX 000466 TGFBR +TGF beta FPLX 000465 TGFB +TGF β receptor FPLX 000466 TGFBR +TGF β FPLX 000465 TGFB +TGF-alpha UP TGFA_HUMAN P01135 +TGF-b FPLX 000465 TGFB +TGF-beta family FPLX 000465 TGFB +TGF-beta receptor FPLX 000466 TGFBR +TGF-beta receptors FPLX 000466 TGFBR +TGF-beta FPLX 000465 TGFB +TGF-beta1 UP TGFB1_HUMAN P01137 +TGF-β receptor FPLX 000466 TGFBR +TGF-β receptors FPLX 000466 TGFBR +TGF-β FPLX 000465 TGFB +TGF-α UP TGFA_HUMAN P01135 +TGF-β1 UP TGFB1_HUMAN P01137 +TGFalpha UP TGFA_HUMAN P01135 +TGFB family FPLX 000465 TGFB +TGFB FPLX 000465 TGFB +TGFbeta FPLX 000465 TGFB +TGFbeta1 UP TGFB1_HUMAN P01137 +TGFBR family FPLX 000466 TGFBR +TGFBR FPLX 000466 TGFBR +TGFβ receptor FPLX 000466 TGFBR +TGFβ receptors FPLX 000466 TGFBR +TGFβ FPLX 000465 TGFB +TGFα UP TGFA_HUMAN P01135 +TGFβ1 UP TGFB1_HUMAN P01137 +thapsigargin PUBCHEM 446378 . +thapsigargin CHEBI thapsigargin CHEBI:9516 +Thioredoxin reductase FPLX 000488 TXNRD +thioredoxin reductase FPLX 000488 TXNRD +Thioredoxin FPLX 000487 TXN +thioredoxin FPLX 000487 TXN +Thioredoxin UP THIO_HUMAN P10599 +thioredoxin UP THIO_HUMAN P10599 +thioredoxins FPLX 000487 TXN +thrombin IP IPR003966 . +thrombin UP THRB_HUMAN P00734 +thrombin-anti-thrombin III complexes FPLX 000469 Thrombin_antithrombin +thrombospondin protein FPLX 000467 THBS +Thrombospondin FPLX 000467 THBS +thrombospondin FPLX 000467 THBS +Thrombospondins FPLX 000467 THBS +thrombospondins FPLX 000467 THBS +thyroid hormone receptor FPLX 000468 THR +TIAM FPLX 000470 TIAM +TIAM1 UP TIAM1_HUMAN Q13009 +Tiam1 UP TIAM1_HUMAN Q13009 +TIAM2 UP TIAM2_HUMAN Q8IVF5 +Tiam2 UP TIAM2_HUMAN Q8IVF5 +TIF-IB FPLX 000471 TIF_IB +tipifarnib PUBCHEM 159324 . +tipifarnib CHEBI tipifarnib CHEBI:141969 +tissue kallikrein FPLX 000271 KLK +tissue kallikreins FPLX 000271 KLK +TLR FPLX 000472 TLR +TLR2 UP TLR2_HUMAN O60603 +TLR4 UP TLR4_HUMAN O00206 +TMZ CHEBI temozolomide CHEBI:72564 +TMZ PUBCHEM 5394 . +TN-C FPLX 000478 Troponin_C +TnC FPLX 000478 Troponin_C +TNF UP TNFA_HUMAN P01375 +TNF-alpha UP TNFA_HUMAN P01375 +TNF-R superfamily FPLX 000475 TNFRSF +TNF-receptor family FPLX 000475 TNFRSF +TNF-α UP TNFA_HUMAN P01375 +TNFalpha UP TNFA_HUMAN P01375 +TNFR family FPLX 000475 TNFRSF +TNFR subfamily FPLX 000475 TNFRSF +TNFR superfamily members FPLX 000475 TNFRSF +TNFR superfamily receptors FPLX 000475 TNFRSF +TNFR superfamily FPLX 000475 TNFRSF +TNFR FPLX 000475 TNFRSF +TNFR1 UP TNR1A_HUMAN P19438 +TNFα UP TNFA_HUMAN P01375 +topoisomerase II FPLX 000476 TOP2 +TORC1 FPLX 000293 mTORC1 +TORC2 FPLX 000294 mTORC2 +TP53 UP P53_HUMAN P04637 +TPA PUBCHEM 27924 . +TPA CHEBI phorbol 13-acetate 12-myristate CHEBI:37537 +Tpl2 HGNC 6860 MAP3K8 +TPNI FPLX 000479 Troponin_I +TPNT FPLX 000480 Troponin_T +TQ PUBCHEM 10281 . +TQ CHEBI 2-methyl-5-propan-2-ylcyclohexa-2,5-diene-1,4-dione CHEBI:113532 +TRAF2 UP TRAF2_HUMAN Q12933 +TRAF3 UP TRAF3_HUMAN Q13114 +TRAF6 UP TRAF6_HUMAN Q9Y4K3 +TRAIL UP TNF10_HUMAN P50591 +trametinib CHEBI trametinib CHEBI:75998 +trametinib PUBCHEM 11707110 . +Transcription factor AP-2 FPLX 000463 TFAP2 +transcription factor AP-2 FPLX 000463 TFAP2 +transcription factor DP FPLX 000464 TFDP +transcription factor II E FPLX 000196 GTF2E +transcription factor II F FPLX 000197 GTF2F +transcription factor IIE FPLX 000196 GTF2E +transcription factor IIF FPLX 000197 GTF2F +transcription GO transcription, DNA-templated GO:0006351 +transcription MESH Transcription, Genetic D014158 +transcriptional cofactor complex CRSP FPLX 000122 CRSP +transforming growth factor beta FPLX 000465 TGFB +transforming growth factor β FPLX 000465 TGFB +transforming growth factor-beta FPLX 000465 TGFB +transforming growth factor-β FPLX 000465 TGFB +translation GO translation GO:0006412 +translation MESH Protein Biosynthesis D014176 +transport GO transport GO:0006810 +trastuzumab MESH Trastuzumab D000068878 +trastuzumab CHEMBL 1201585 . +TRiC FPLX 000085 CCT_complex +TRIM UP TRAT1_HUMAN Q6PIZ9 +Trk receptor FPLX 000321 NTRK +trk receptor FPLX 000321 NTRK +Trk receptors FPLX 000321 NTRK +trk receptors FPLX 000321 NTRK +TrkA UP NTRK1_HUMAN P04629 +TrkB UP NTRK2_HUMAN Q16620 +troponin C FPLX 000478 Troponin_C +troponin complex FPLX 000477 Troponin +troponin I FPLX 000479 Troponin_I +troponin T FPLX 000480 Troponin_T +troponin FPLX 000477 Troponin +troponins FPLX 000477 Troponin +trypsin CHEBI Trypsin CHEBI:9765 +Tryptase FPLX 000481 Tryptase +tryptase FPLX 000481 Tryptase +tryptases FPLX 000481 Tryptase +TSA PUBCHEM 444732 . +TSA CHEBI trichostatin A CHEBI:46024 +TSC FPLX 000482 TSC +TSC1 UP TSC1_HUMAN Q92574 +TSC2 UP TSC2_HUMAN P49815 +TUBA FPLX 000483 TUBA +TUBB FPLX 000484 TUBB +tuberin UP TSC2_HUMAN P49815 +tubulin alpha chain FPLX 000483 TUBA +tubulin beta chain FPLX 000484 TUBB +tubulin beta FPLX 000484 TUBB +tubulin delta HGNC 16811 TUBD1 +tubulin epsilon HGNC 20775 TUBE1 +tubulin gamma FPLX 000485 TUBG +tubulin α chain FPLX 000483 TUBA +tubulin β chain FPLX 000484 TUBB +tubulin β FPLX 000484 TUBB +tubulin γ FPLX 000485 TUBG +tubulin δ HGNC 16811 TUBD1 +tubulin ε HGNC 20775 TUBE1 +tubulin FPLX 000486 Tubulin +tumor necrosis factor UP TNFA_HUMAN P01375 +tumorigenesis MESH Carcinogenesis D063646 +tunicamycin CHEBI tunicamycin CHEBI:29699 +tunicamycin PUBCHEM 56927680 . +type 2 phosphatidic acid phosphatase FPLX 000374 PPAP2 +type 2 phosphatidic acid phosphatases FPLX 000374 PPAP2 +type 4 cyclic nucleotide phosphodiesterase FPLX 000338 PDE4 +Type I collagen FPLX 000109 COL1 +type I collagen FPLX 000109 COL1 +type II phosphatidic acid phosphatase FPLX 000374 PPAP2 +type II phosphatidic acid phosphatases FPLX 000374 PPAP2 +type V collagen FPLX 000111 COL5 +type-V collagen FPLX 000111 COL5 +U0126 PUBCHEM 3006531 . +U0126 CHEBI U0126 CHEBI:90693 +Ub FPLX 000490 Ubiquitin +ub FPLX 000490 Ubiquitin +UBE2 FPLX 000489 UBE2 +ubiquitin conjugating enzyme FPLX 000489 UBE2 +Ubiquitin FPLX 000490 Ubiquitin +ubiquitin FPLX 000490 Ubiquitin +ubiquitin-conjugating enzymes FPLX 000489 UBE2 +UGT FPLX 000492 UGT +uPA UP UROK_HUMAN P00749 +uPAR UP UPAR_HUMAN Q03405 +vascular endothelial growth factor FPLX 000495 VEGF +VAV family FPLX 000494 VAV +Vav FPLX 000494 VAV +Vav1 UP VAV_HUMAN P15498 +VCAM-1 UP VCAM1_HUMAN P19320 +VEGF receptor FPLX 000496 VEGFR +VEGF receptors FPLX 000496 VEGFR +VEGF FPLX 000495 VEGF +VEGF-A UP VEGFA_HUMAN P15692 +VEGFR ligand FPLX 000496 VEGFR +VEGFR FPLX 000496 VEGFR +VEGFR-2 UP VGFR2_HUMAN P35968 +VEGFR2 UP VGFR2_HUMAN P35968 +VEGFRs FPLX 000496 VEGFR +Vemurafenib PUBCHEM 42611257 . +Vemurafenib CHEBI vemurafenib CHEBI:63637 +vemurafenib PUBCHEM 42611257 . +vemurafenib CHEBI vemurafenib CHEBI:63637 +vitronectin receptor (integrin) FPLX 000261 Integrins +VLDL CHEBI very-low-density lipoprotein CHEBI:39027 +vorinostat PUBCHEM 5311 . +vorinostat CHEBI vorinostat CHEBI:45716 +VPA PUBCHEM 3121 . +VPA CHEBI valproic acid CHEBI:39867 +Vpr UP VPR_HV1BR P05928 +Vpu UP VPU_HV1H2 P05919 +WA PUBCHEM 265237 . +WA CHEBI withaferin A CHEBI:69120 +wild type c-Cbl UP CBL_HUMAN P22681 +WNT FPLX 000497 Wnt +Wnt FPLX 000497 Wnt +Wnt5a UP WNT5A_HUMAN P41221 +wogonin PUBCHEM 5281703 . +wogonin CHEBI wogonin CHEBI:10043 +XIAP UP XIAP_HUMAN P98170 +XYLT FPLX 000185 GCNT +Xylosyltransferase FPLX 000185 GCNT +Xylosyltransferases FPLX 000185 GCNT +xylosyltransferase FPLX 000185 GCNT +xylosyltransferases FPLX 000185 GCNT +Y box binding protein FPLX 000498 YBX +Y-box-binding protein FPLX 000498 YBX +YAP UP YAP1_HUMAN P46937 +YAP1 UP YAP1_HUMAN P46937 +YBX protein family FPLX 000498 YBX +ZEB1 UP ZEB1_HUMAN P37275 +Zeb1 UP ZEB1_HUMAN P37275 +β adrenergic receptor kinase FPLX 000022 ADRBK +α catenin FPLX 000126 CTNNA +β interferons FPLX 000247 IFNB +γ secretase FPLX 000181 Gamma_secretase +α tubulin FPLX 000483 TUBA +γ tubulin FPLX 000485 TUBG +α(2)-adrenoceptors FPLX 000020 ADRA2 +α(2)-ARs FPLX 000020 ADRA2 +α-adrenergic receptor FPLX 000019 ADRA +β-adrenergic receptor FPLX 000021 ADRB +α-adrenoreceptor FPLX 000019 ADRA +β-adrenoreceptor FPLX 000021 ADRB +α-adrenoreceptors FPLX 000019 ADRA +γ-aminobutyric-acid A receptor FPLX 000179 GABR +α-catenin FPLX 000126 CTNNA +β-catenin UP CTNB1_HUMAN P35222 +β-TrCP UP FBW1A_HUMAN Q9Y297 +γ-tubulin FPLX 000485 TUBG +δ-tubulin HGNC 16811 TUBD1 +ε-tubulin HGNC 20775 TUBE1 +α1β1γ1 FPLX 000032 AMPK_A1B1G1 +α1β1γ2 FPLX 000033 AMPK_A1B1G2 +α1β1γ3 FPLX 000034 AMPK_A1B1G3 +α1β2γ1 FPLX 000035 AMPK_A1B2G1 +α1β2γ2 FPLX 000036 AMPK_A1B2G2 +α2-AR FPLX 000020 ADRA2 +α2β1γ1 FPLX 000038 AMPK_A2B1G1 +α2β2γ1 FPLX 000041 AMPK_A2B2G1 +α2β2γ2 FPLX 000042 AMPK_A2B2G2 +α2β2γ3 FPLX 000043 AMPK_A2B2G3 +βAR FPLX 000021 ADRB +βARK FPLX 000022 ADRBK +receptor GO signaling receptor activity GO:0038023 +eGFR MESH Glomerular Filtration Rate D005919 +CDK1/2 FPLX 000093 CDK1_2 +cdk1/2 FPLX 000093 CDK1_2 +Cdk1/2 FPLX 000093 CDK1_2 +cell migration MESH Cell Movement D002465 +cell migration NCIT C26169 . +cell migration GO cell migration GO:0016477 +cell motility MESH Cell Movement D002465 +cell motility NCIT C16404 . +cell motility GO cell motility GO:0048870 +Chk1/2 FPLX 000098 CHEK +chromosomal instability MESH Chromosomal Instability D043171 +chromosomal instability NCIT C48195 . +chromosomal instabiliy MESH Chromosomal Instability D043171 +chromosomal instabiliy NCIT C48195 . +CIN MESH Chromosomal Instability D043171 +CIN NCIT C48195 . +CycK HGNC 1596 CCNK +CycK1 HGNC 1596 CCNK +dinaciclib PUBCHEM 46926350 . +dinaciclib CHEMBL CHEMBL2103840 . +dinaciclib CHEBI 2-[(2S)-1-[3-ethyl-7-[(1-oxido-3-pyridin-1-iumyl)methylamino]-5-pyrazolo[1,5-a]pyrimidinyl]-2-piperidinyl]ethanol CHEBI:95060 +Dinaciclib PUBCHEM 46926350 . +Dinaciclib CHEMBL CHEMBL2103840 . +Dinaciclib CHEBI 2-[(2S)-1-[3-ethyl-7-[(1-oxido-3-pyridin-1-iumyl)methylamino]-5-pyrazolo[1,5-a]pyrimidinyl]-2-piperidinyl]ethanol CHEBI:95060 +Ebp1 HGNC 8550 PA2G4 +EBP1 HGNC 8550 PA2G4 +erbB FPLX 000160 ERBB +Fer-1 PUBCHEM 4068248 . +HK2 HGNC 4923 HK2 +NLE CHEBI azadirachtin CHEBI:38473 +PD-1 UP PDCD1_HUMAN Q15116 +PD-1 HGNC 8760 PDCD1 +Se PUBCHEM 6326970 . +Se CHEBI selenium atom CHEBI:27568 +THZ531 PUBCHEM 118025540 . +THZ531 CHEBI THZ531 CHEBI:143122 +Hh FPLX 000226 Hedgehog +SIK FPLX 000433 SIK +salt inducible kinase FPLX 000433 SIK +Sik UP PTK6_MOUSE Q64434 +DYRK FPLX 000146 DYRK +Augmin FPLX 000061 Augmin +HAUS FPLX 000061 Augmin +HAUS complex FPLX 000061 Augmin +CRTC FPLX 000123 CRTC diff --git a/famplex/resources/metadata.json b/famplex/resources/metadata.json new file mode 100644 index 000000000..f8cde74ee --- /dev/null +++ b/famplex/resources/metadata.json @@ -0,0 +1,710 @@ +{ + "Time Exported": "Sun Jul 21 17:01:05 2019", + "Unlabelled Groundings": [ + { + "db": "CHEMBL", + "db_id": "1201577" + }, + { + "db": "CHEMBL", + "db_id": "1201585" + }, + { + "db": "CHEMBL", + "db_id": "CHEMBL2103840" + }, + { + "db": "CHEMBL", + "db_id": "CHEMBL402548" + }, + { + "db": "CHEMBL", + "db_id": "CHEMBL98" + }, + { + "db": "HMDB", + "db_id": "HMDB00045" + }, + { + "db": "HMDB", + "db_id": "HMDB00058" + }, + { + "db": "HMDB", + "db_id": "HMDB00108" + }, + { + "db": "HMDB", + "db_id": "HMDB00122" + }, + { + "db": "HMDB", + "db_id": "HMDB00125" + }, + { + "db": "HMDB", + "db_id": "HMDB00220" + }, + { + "db": "HMDB", + "db_id": "HMDB00221" + }, + { + "db": "HMDB", + "db_id": "HMDB00464" + }, + { + "db": "HMDB", + "db_id": "HMDB00538" + }, + { + "db": "HMDB", + "db_id": "HMDB01201" + }, + { + "db": "HMDB", + "db_id": "HMDB01273" + }, + { + "db": "HMDB", + "db_id": "HMDB01377" + }, + { + "db": "HMDB", + "db_id": "HMDB03378" + }, + { + "db": "HMDB", + "db_id": "HMDB06219" + }, + { + "db": "IP", + "db_id": "IPR000529" + }, + { + "db": "IP", + "db_id": "IPR003966" + }, + { + "db": "IP", + "db_id": "IPR015503" + }, + { + "db": "LINCS", + "db_id": "10023-103" + }, + { + "db": "LINCS", + "db_id": "10133-101" + }, + { + "db": "LINCS", + "db_id": "10232-101" + }, + { + "db": "LNCRNADB", + "db_id": "HOTAIR" + }, + { + "db": "NCIT", + "db_id": "C16404" + }, + { + "db": "NCIT", + "db_id": "C26169" + }, + { + "db": "NCIT", + "db_id": "C48195" + }, + { + "db": "NONCODE", + "db_id": "NONHSAT028507.2" + }, + { + "db": "PUBCHEM", + "db_id": "10127622" + }, + { + "db": "PUBCHEM", + "db_id": "10184653" + }, + { + "db": "PUBCHEM", + "db_id": "10281" + }, + { + "db": "PUBCHEM", + "db_id": "10494" + }, + { + "db": "PUBCHEM", + "db_id": "10836" + }, + { + "db": "PUBCHEM", + "db_id": "11302" + }, + { + "db": "PUBCHEM", + "db_id": "11442891" + }, + { + "db": "PUBCHEM", + "db_id": "11707110" + }, + { + "db": "PUBCHEM", + "db_id": "118025540" + }, + { + "db": "PUBCHEM", + "db_id": "11977753" + }, + { + "db": "PUBCHEM", + "db_id": "123631" + }, + { + "db": "PUBCHEM", + "db_id": "124886" + }, + { + "db": "PUBCHEM", + "db_id": "135398619" + }, + { + "db": "PUBCHEM", + "db_id": "135398633" + }, + { + "db": "PUBCHEM", + "db_id": "135398634" + }, + { + "db": "PUBCHEM", + "db_id": "135565635" + }, + { + "db": "PUBCHEM", + "db_id": "145068" + }, + { + "db": "PUBCHEM", + "db_id": "148124" + }, + { + "db": "PUBCHEM", + "db_id": "1548943" + }, + { + "db": "PUBCHEM", + "db_id": "159324" + }, + { + "db": "PUBCHEM", + "db_id": "161468" + }, + { + "db": "PUBCHEM", + "db_id": "16755649" + }, + { + "db": "PUBCHEM", + "db_id": "176155" + }, + { + "db": "PUBCHEM", + "db_id": "176870" + }, + { + "db": "PUBCHEM", + "db_id": "208908" + }, + { + "db": "PUBCHEM", + "db_id": "216239" + }, + { + "db": "PUBCHEM", + "db_id": "2214" + }, + { + "db": "PUBCHEM", + "db_id": "2244" + }, + { + "db": "PUBCHEM", + "db_id": "2346" + }, + { + "db": "PUBCHEM", + "db_id": "2353" + }, + { + "db": "PUBCHEM", + "db_id": "23925" + }, + { + "db": "PUBCHEM", + "db_id": "23973" + }, + { + "db": "PUBCHEM", + "db_id": "24775005" + }, + { + "db": "PUBCHEM", + "db_id": "2519" + }, + { + "db": "PUBCHEM", + "db_id": "25227462" + }, + { + "db": "PUBCHEM", + "db_id": "265237" + }, + { + "db": "PUBCHEM", + "db_id": "2662" + }, + { + "db": "PUBCHEM", + "db_id": "27099" + }, + { + "db": "PUBCHEM", + "db_id": "271" + }, + { + "db": "PUBCHEM", + "db_id": "2733526" + }, + { + "db": "PUBCHEM", + "db_id": "27854" + }, + { + "db": "PUBCHEM", + "db_id": "27924" + }, + { + "db": "PUBCHEM", + "db_id": "280" + }, + { + "db": "PUBCHEM", + "db_id": "281" + }, + { + "db": "PUBCHEM", + "db_id": "2871439" + }, + { + "db": "PUBCHEM", + "db_id": "2912" + }, + { + "db": "PUBCHEM", + "db_id": "29327" + }, + { + "db": "PUBCHEM", + "db_id": "3006531" + }, + { + "db": "PUBCHEM", + "db_id": "3062316" + }, + { + "db": "PUBCHEM", + "db_id": "3121" + }, + { + "db": "PUBCHEM", + "db_id": "31703" + }, + { + "db": "PUBCHEM", + "db_id": "3218" + }, + { + "db": "PUBCHEM", + "db_id": "3220" + }, + { + "db": "PUBCHEM", + "db_id": "36462" + }, + { + "db": "PUBCHEM", + "db_id": "370" + }, + { + "db": "PUBCHEM", + "db_id": "375150" + }, + { + "db": "PUBCHEM", + "db_id": "3763" + }, + { + "db": "PUBCHEM", + "db_id": "387447" + }, + { + "db": "PUBCHEM", + "db_id": "4068248" + }, + { + "db": "PUBCHEM", + "db_id": "4091" + }, + { + "db": "PUBCHEM", + "db_id": "42611257" + }, + { + "db": "PUBCHEM", + "db_id": "441203" + }, + { + "db": "PUBCHEM", + "db_id": "442534" + }, + { + "db": "PUBCHEM", + "db_id": "44259" + }, + { + "db": "PUBCHEM", + "db_id": "443227" + }, + { + "db": "PUBCHEM", + "db_id": "44462760" + }, + { + "db": "PUBCHEM", + "db_id": "444732" + }, + { + "db": "PUBCHEM", + "db_id": "444795" + }, + { + "db": "PUBCHEM", + "db_id": "445154" + }, + { + "db": "PUBCHEM", + "db_id": "446220" + }, + { + "db": "PUBCHEM", + "db_id": "446378" + }, + { + "db": "PUBCHEM", + "db_id": "446512" + }, + { + "db": "PUBCHEM", + "db_id": "462382" + }, + { + "db": "PUBCHEM", + "db_id": "46907787" + }, + { + "db": "PUBCHEM", + "db_id": "46926350" + }, + { + "db": "PUBCHEM", + "db_id": "479503" + }, + { + "db": "PUBCHEM", + "db_id": "4878" + }, + { + "db": "PUBCHEM", + "db_id": "518605" + }, + { + "db": "PUBCHEM", + "db_id": "5280343" + }, + { + "db": "PUBCHEM", + "db_id": "5280443" + }, + { + "db": "PUBCHEM", + "db_id": "5280445" + }, + { + "db": "PUBCHEM", + "db_id": "5280805" + }, + { + "db": "PUBCHEM", + "db_id": "5280896" + }, + { + "db": "PUBCHEM", + "db_id": "5280961" + }, + { + "db": "PUBCHEM", + "db_id": "5281222" + }, + { + "db": "PUBCHEM", + "db_id": "5281611" + }, + { + "db": "PUBCHEM", + "db_id": "5281612" + }, + { + "db": "PUBCHEM", + "db_id": "5281614" + }, + { + "db": "PUBCHEM", + "db_id": "5281647" + }, + { + "db": "PUBCHEM", + "db_id": "5281703" + }, + { + "db": "PUBCHEM", + "db_id": "5281787" + }, + { + "db": "PUBCHEM", + "db_id": "5281847" + }, + { + "db": "PUBCHEM", + "db_id": "5284373" + }, + { + "db": "PUBCHEM", + "db_id": "5284616" + }, + { + "db": "PUBCHEM", + "db_id": "5291" + }, + { + "db": "PUBCHEM", + "db_id": "5311" + }, + { + "db": "PUBCHEM", + "db_id": "5350" + }, + { + "db": "PUBCHEM", + "db_id": "5352425" + }, + { + "db": "PUBCHEM", + "db_id": "5359596" + }, + { + "db": "PUBCHEM", + "db_id": "5359597" + }, + { + "db": "PUBCHEM", + "db_id": "5394" + }, + { + "db": "PUBCHEM", + "db_id": "544" + }, + { + "db": "PUBCHEM", + "db_id": "54454" + }, + { + "db": "PUBCHEM", + "db_id": "54671203" + }, + { + "db": "PUBCHEM", + "db_id": "5469318" + }, + { + "db": "PUBCHEM", + "db_id": "5538" + }, + { + "db": "PUBCHEM", + "db_id": "56927680" + }, + { + "db": "PUBCHEM", + "db_id": "5743" + }, + { + "db": "PUBCHEM", + "db_id": "5746" + }, + { + "db": "PUBCHEM", + "db_id": "5839" + }, + { + "db": "PUBCHEM", + "db_id": "5884" + }, + { + "db": "PUBCHEM", + "db_id": "5957" + }, + { + "db": "PUBCHEM", + "db_id": "5994" + }, + { + "db": "PUBCHEM", + "db_id": "5997" + }, + { + "db": "PUBCHEM", + "db_id": "6022" + }, + { + "db": "PUBCHEM", + "db_id": "6026790" + }, + { + "db": "PUBCHEM", + "db_id": "6076" + }, + { + "db": "PUBCHEM", + "db_id": "6083" + }, + { + "db": "PUBCHEM", + "db_id": "6112" + }, + { + "db": "PUBCHEM", + "db_id": "6325610" + }, + { + "db": "PUBCHEM", + "db_id": "6326970" + }, + { + "db": "PUBCHEM", + "db_id": "6442177" + }, + { + "db": "PUBCHEM", + "db_id": "6444692" + }, + { + "db": "PUBCHEM", + "db_id": "65064" + }, + { + "db": "PUBCHEM", + "db_id": "65110" + }, + { + "db": "PUBCHEM", + "db_id": "6623" + }, + { + "db": "PUBCHEM", + "db_id": "67501411" + }, + { + "db": "PUBCHEM", + "db_id": "681" + }, + { + "db": "PUBCHEM", + "db_id": "6857599" + }, + { + "db": "PUBCHEM", + "db_id": "68827" + }, + { + "db": "PUBCHEM", + "db_id": "6918483" + }, + { + "db": "PUBCHEM", + "db_id": "702" + }, + { + "db": "PUBCHEM", + "db_id": "73659" + }, + { + "db": "PUBCHEM", + "db_id": "77999" + }, + { + "db": "PUBCHEM", + "db_id": "784" + }, + { + "db": "PUBCHEM", + "db_id": "8144759" + }, + { + "db": "PUBCHEM", + "db_id": "8249" + }, + { + "db": "PUBCHEM", + "db_id": "8515" + }, + { + "db": "PUBCHEM", + "db_id": "896" + }, + { + "db": "PUBCHEM", + "db_id": "91435" + }, + { + "db": "PUBCHEM", + "db_id": "969516" + }, + { + "db": "PUBCHEM", + "db_id": "977" + }, + { + "db": "PUBCHEM", + "db_id": "9811784" + }, + { + "db": "PUBCHEM", + "db_id": "9847290" + }, + { + "db": "PUBCHEM", + "db_id": "985" + }, + { + "db": "PUBCHEM", + "db_id": "9887712" + } + ], + "Unlabelled Relations": [] +} \ No newline at end of file diff --git a/famplex/resources/relations.tsv b/famplex/resources/relations.tsv new file mode 100644 index 000000000..778c2c004 --- /dev/null +++ b/famplex/resources/relations.tsv @@ -0,0 +1,2784 @@ +HGNC 3288 EIF4EBP1 isa FPLX 000154 EIF4EBP +HGNC 3289 EIF4EBP2 isa FPLX 000154 EIF4EBP +HGNC 3290 EIF4EBP3 isa FPLX 000154 EIF4EBP +HGNC 129 ACTA1 isa FPLX 000009 Actin +HGNC 130 ACTA2 isa FPLX 000009 Actin +HGNC 132 ACTB isa FPLX 000009 Actin +HGNC 143 ACTC1 isa FPLX 000009 Actin +HGNC 144 ACTG1 isa FPLX 000009 Actin +HGNC 145 ACTG2 isa FPLX 000009 Actin +FPLX 000011 Activin_A isa FPLX 000010 Activin +FPLX 000012 Activin_AB isa FPLX 000010 Activin +FPLX 000013 Activin_B isa FPLX 000010 Activin +FPLX 000257 Inhibin_A isa FPLX 000256 Inhibin +FPLX 000258 Inhibin_B isa FPLX 000256 Inhibin +HGNC 6066 INHBA partof FPLX 000011 Activin_A +HGNC 6066 INHBA partof FPLX 000012 Activin_AB +HGNC 6067 INHBB partof FPLX 000012 Activin_AB +HGNC 6067 INHBB partof FPLX 000013 Activin_B +HGNC 6065 INHA partof FPLX 000257 Inhibin_A +HGNC 6066 INHBA partof FPLX 000257 Inhibin_A +HGNC 6065 INHA partof FPLX 000258 Inhibin_B +HGNC 6067 INHBB partof FPLX 000258 Inhibin_B +HGNC 391 AKT1 isa FPLX 000023 AKT +HGNC 392 AKT2 isa FPLX 000023 AKT +HGNC 393 AKT3 isa FPLX 000023 AKT +FPLX 000044 AMPK_alpha partof FPLX 000031 AMPK +FPLX 000045 AMPK_beta partof FPLX 000031 AMPK +FPLX 000046 AMPK_gamma partof FPLX 000031 AMPK +HGNC 9376 PRKAA1 isa FPLX 000044 AMPK_alpha +HGNC 9377 PRKAA2 isa FPLX 000044 AMPK_alpha +HGNC 9378 PRKAB1 isa FPLX 000045 AMPK_beta +HGNC 9379 PRKAB2 isa FPLX 000045 AMPK_beta +HGNC 9385 PRKAG1 isa FPLX 000046 AMPK_gamma +HGNC 9386 PRKAG2 isa FPLX 000046 AMPK_gamma +HGNC 9387 PRKAG3 isa FPLX 000046 AMPK_gamma +FPLX 000032 AMPK_A1B1G1 isa FPLX 000031 AMPK +HGNC 9376 PRKAA1 partof FPLX 000032 AMPK_A1B1G1 +HGNC 9378 PRKAB1 partof FPLX 000032 AMPK_A1B1G1 +HGNC 9385 PRKAG1 partof FPLX 000032 AMPK_A1B1G1 +FPLX 000033 AMPK_A1B1G2 isa FPLX 000031 AMPK +HGNC 9376 PRKAA1 partof FPLX 000033 AMPK_A1B1G2 +HGNC 9378 PRKAB1 partof FPLX 000033 AMPK_A1B1G2 +HGNC 9386 PRKAG2 partof FPLX 000033 AMPK_A1B1G2 +FPLX 000034 AMPK_A1B1G3 isa FPLX 000031 AMPK +HGNC 9376 PRKAA1 partof FPLX 000034 AMPK_A1B1G3 +HGNC 9378 PRKAB1 partof FPLX 000034 AMPK_A1B1G3 +HGNC 9387 PRKAG3 partof FPLX 000034 AMPK_A1B1G3 +FPLX 000035 AMPK_A1B2G1 isa FPLX 000031 AMPK +HGNC 9376 PRKAA1 partof FPLX 000035 AMPK_A1B2G1 +HGNC 9379 PRKAB2 partof FPLX 000035 AMPK_A1B2G1 +HGNC 9385 PRKAG1 partof FPLX 000035 AMPK_A1B2G1 +FPLX 000036 AMPK_A1B2G2 isa FPLX 000031 AMPK +HGNC 9376 PRKAA1 partof FPLX 000036 AMPK_A1B2G2 +HGNC 9379 PRKAB2 partof FPLX 000036 AMPK_A1B2G2 +HGNC 9386 PRKAG2 partof FPLX 000036 AMPK_A1B2G2 +FPLX 000037 AMPK_A1B2G3 isa FPLX 000031 AMPK +HGNC 9376 PRKAA1 partof FPLX 000037 AMPK_A1B2G3 +HGNC 9379 PRKAB2 partof FPLX 000037 AMPK_A1B2G3 +HGNC 9387 PRKAG3 partof FPLX 000037 AMPK_A1B2G3 +FPLX 000038 AMPK_A2B1G1 isa FPLX 000031 AMPK +HGNC 9377 PRKAA2 partof FPLX 000038 AMPK_A2B1G1 +HGNC 9378 PRKAB1 partof FPLX 000038 AMPK_A2B1G1 +HGNC 9385 PRKAG1 partof FPLX 000038 AMPK_A2B1G1 +FPLX 000039 AMPK_A2B1G2 isa FPLX 000031 AMPK +HGNC 9377 PRKAA2 partof FPLX 000039 AMPK_A2B1G2 +HGNC 9378 PRKAB1 partof FPLX 000039 AMPK_A2B1G2 +HGNC 9386 PRKAG2 partof FPLX 000039 AMPK_A2B1G2 +FPLX 000040 AMPK_A2B1G3 isa FPLX 000031 AMPK +HGNC 9377 PRKAA2 partof FPLX 000040 AMPK_A2B1G3 +HGNC 9378 PRKAB1 partof FPLX 000040 AMPK_A2B1G3 +HGNC 9387 PRKAG3 partof FPLX 000040 AMPK_A2B1G3 +FPLX 000041 AMPK_A2B2G1 isa FPLX 000031 AMPK +HGNC 9377 PRKAA2 partof FPLX 000041 AMPK_A2B2G1 +HGNC 9379 PRKAB2 partof FPLX 000041 AMPK_A2B2G1 +HGNC 9385 PRKAG1 partof FPLX 000041 AMPK_A2B2G1 +FPLX 000042 AMPK_A2B2G2 isa FPLX 000031 AMPK +HGNC 9377 PRKAA2 partof FPLX 000042 AMPK_A2B2G2 +HGNC 9379 PRKAB2 partof FPLX 000042 AMPK_A2B2G2 +HGNC 9386 PRKAG2 partof FPLX 000042 AMPK_A2B2G2 +FPLX 000043 AMPK_A2B2G3 isa FPLX 000031 AMPK +HGNC 9377 PRKAA2 partof FPLX 000043 AMPK_A2B2G3 +HGNC 9379 PRKAB2 partof FPLX 000043 AMPK_A2B2G3 +HGNC 9387 PRKAG3 partof FPLX 000043 AMPK_A2B2G3 +HGNC 561 AP2A1 isa FPLX 000049 AP2A +HGNC 562 AP2A2 isa FPLX 000049 AP2A +HGNC 563 AP2B1 partof FPLX 000015 Adaptor_protein_II +HGNC 564 AP2M1 partof FPLX 000015 Adaptor_protein_II +HGNC 565 AP2S1 partof FPLX 000015 Adaptor_protein_II +FPLX 000049 AP2A partof FPLX 000015 Adaptor_protein_II +HGNC 3796 FOS isa FPLX 000173 FOS_family +HGNC 3797 FOSB isa FPLX 000173 FOS_family +HGNC 13718 FOSL1 isa FPLX 000173 FOS_family +HGNC 3798 FOSL2 isa FPLX 000173 FOS_family +FPLX 000173 FOS_family partof FPLX 000048 AP1 +HGNC 6204 JUN isa FPLX 000268 JUN_family +HGNC 6205 JUNB isa FPLX 000268 JUN_family +HGNC 6206 JUND isa FPLX 000268 JUN_family +FPLX 000268 JUN_family partof FPLX 000048 AP1 +HGNC 1499 CASP1 isa FPLX 000081 Caspase +HGNC 1503 CASP2 isa FPLX 000081 Caspase +HGNC 1504 CASP3 isa FPLX 000082 Caspase_3_7 +HGNC 1505 CASP4 isa FPLX 000081 Caspase +HGNC 1506 CASP5 isa FPLX 000081 Caspase +HGNC 1507 CASP6 isa FPLX 000081 Caspase +HGNC 1508 CASP7 isa FPLX 000082 Caspase_3_7 +HGNC 1509 CASP8 isa FPLX 000081 Caspase +HGNC 1511 CASP9 isa FPLX 000081 Caspase +HGNC 1500 CASP10 isa FPLX 000081 Caspase +HGNC 19004 CASP12 isa FPLX 000081 Caspase +HGNC 1502 CASP14 isa FPLX 000081 Caspase +FPLX 000082 Caspase_3_7 isa FPLX 000081 Caspase +HGNC 1781 CDKL1 isa FPLX 000092 CDK +HGNC 1782 CDKL2 isa FPLX 000092 CDK +HGNC 15483 CDKL3 isa FPLX 000092 CDK +HGNC 19287 CDKL4 isa FPLX 000092 CDK +HGNC 11411 CDKL5 isa FPLX 000092 CDK +HGNC 1722 CDK1 isa FPLX 000093 CDK1_2 +HGNC 1771 CDK2 isa FPLX 000093 CDK1_2 +FPLX 000093 CDK1_2 isa FPLX 000092 CDK +HGNC 1772 CDK3 isa FPLX 000092 CDK +HGNC 1773 CDK4 isa FPLX 000092 CDK +HGNC 1774 CDK5 isa FPLX 000092 CDK +HGNC 1777 CDK6 isa FPLX 000092 CDK +HGNC 1778 CDK7 isa FPLX 000092 CDK +HGNC 1779 CDK8 isa FPLX 000092 CDK +HGNC 1780 CDK9 isa FPLX 000092 CDK +HGNC 1770 CDK10 isa FPLX 000092 CDK +HGNC 1730 CDK11A isa FPLX 000092 CDK +HGNC 1729 CDK11B isa FPLX 000092 CDK +HGNC 24224 CDK12 isa FPLX 000092 CDK +HGNC 1733 CDK13 isa FPLX 000092 CDK +HGNC 8883 CDK14 isa FPLX 000092 CDK +HGNC 14434 CDK15 isa FPLX 000092 CDK +HGNC 8749 CDK16 isa FPLX 000092 CDK +HGNC 8750 CDK17 isa FPLX 000092 CDK +HGNC 8751 CDK18 isa FPLX 000092 CDK +HGNC 19338 CDK19 isa FPLX 000092 CDK +HGNC 21420 CDK20 isa FPLX 000092 CDK +HGNC 2457 CSNK2A1 isa FPLX 000125 CSNK2 +HGNC 2459 CSNK2A2 isa FPLX 000125 CSNK2 +HGNC 2457 CSNK2A1 partof FPLX 000104 CK2 +HGNC 2459 CSNK2A2 partof FPLX 000104 CK2 +HGNC 2460 CSNK2B partof FPLX 000104 CK2 +HGNC 2451 CSNK1A1 isa FPLX 000124 CSNK1 +HGNC 20289 CSNK1A1L isa FPLX 000124 CSNK1 +HGNC 2452 CSNK1D isa FPLX 000124 CSNK1 +HGNC 2453 CSNK1E isa FPLX 000124 CSNK1 +HGNC 2454 CSNK1G1 isa FPLX 000124 CSNK1 +HGNC 2455 CSNK1G2 isa FPLX 000124 CSNK1 +HGNC 2456 CSNK1G3 isa FPLX 000124 CSNK1 +HGNC 1874 CFL1 isa FPLX 000107 Cofilin +HGNC 1875 CFL2 isa FPLX 000107 Cofilin +HGNC 15750 DSTN isa FPLX 000107 Cofilin +HGNC 2345 CREB1 isa FPLX 000120 CREB +HGNC 2347 CREB3 isa FPLX 000120 CREB +HGNC 16844 CREB5 isa FPLX 000120 CREB +HGNC 18856 CREB3L1 isa FPLX 000120 CREB +HGNC 23720 CREB3L2 isa FPLX 000120 CREB +HGNC 18855 CREB3L3 isa FPLX 000120 CREB +HGNC 18854 CREB3L4 isa FPLX 000120 CREB +HGNC 2352 CREM isa FPLX 000120 CREB +HGNC 783 ATF1 isa FPLX 000120 CREB +HGNC 784 ATF2 isa FPLX 000120 CREB +HGNC 1577 CCNA1 isa FPLX 000131 Cyclin_A +HGNC 1578 CCNA2 isa FPLX 000131 Cyclin_A +HGNC 1579 CCNB1 isa FPLX 000130 Cyclin +HGNC 1580 CCNB2 isa FPLX 000130 Cyclin +HGNC 18709 CCNB3 isa FPLX 000130 Cyclin +HGNC 1581 CCNC isa FPLX 000130 Cyclin +HGNC 1582 CCND1 isa FPLX 000132 Cyclin_D +HGNC 1583 CCND2 isa FPLX 000132 Cyclin_D +HGNC 1585 CCND3 isa FPLX 000132 Cyclin_D +HGNC 1589 CCNE1 isa FPLX 000133 Cyclin_E +HGNC 1590 CCNE2 isa FPLX 000133 Cyclin_E +HGNC 1591 CCNF isa FPLX 000130 Cyclin +HGNC 1592 CCNG1 isa FPLX 000130 Cyclin +HGNC 1593 CCNG2 isa FPLX 000130 Cyclin +HGNC 1594 CCNH isa FPLX 000130 Cyclin +HGNC 1595 CCNI isa FPLX 000130 Cyclin +HGNC 33869 CCNI2 isa FPLX 000130 Cyclin +HGNC 23434 CCNJ isa FPLX 000130 Cyclin +HGNC 25876 CCNJL isa FPLX 000130 Cyclin +HGNC 1596 CCNK isa FPLX 000130 Cyclin +HGNC 20569 CCNL1 isa FPLX 000130 Cyclin +HGNC 20570 CCNL2 isa FPLX 000130 Cyclin +HGNC 18576 CCNO isa FPLX 000130 Cyclin +HGNC 1599 CCNT1 isa FPLX 000130 Cyclin +HGNC 1600 CCNT2 isa FPLX 000130 Cyclin +HGNC 23354 CCNY isa FPLX 000130 Cyclin +HGNC 26868 CCNYL1 isa FPLX 000130 Cyclin +HGNC 33206 CCNYL3 isa FPLX 000130 Cyclin +FPLX 000131 Cyclin_A isa FPLX 000130 Cyclin +FPLX 000132 Cyclin_D isa FPLX 000130 Cyclin +FPLX 000133 Cyclin_E isa FPLX 000130 Cyclin +HGNC 6871 MAPK1 isa FPLX 000161 ERK +HGNC 6877 MAPK3 isa FPLX 000161 ERK +FPLX 000161 ERK isa FPLX 000283 MAPK +FPLX 000178 F_actin isa FPLX 000009 Actin +HGNC 3688 FGFR1 isa FPLX 000168 FGFR +HGNC 3689 FGFR2 isa FPLX 000168 FGFR +HGNC 3690 FGFR3 isa FPLX 000168 FGFR +HGNC 3691 FGFR4 isa FPLX 000168 FGFR +HGNC 3693 FGFRL1 isa FPLX 000168 FGFR +HGNC 4616 GSK3A isa FPLX 000194 GSK3 +HGNC 4617 GSK3B isa FPLX 000194 GSK3 +HGNC 4852 HDAC1 isa FPLX 000221 HDAC_I +HGNC 4853 HDAC2 isa FPLX 000221 HDAC_I +HGNC 4854 HDAC3 isa FPLX 000221 HDAC_I +HGNC 13315 HDAC8 isa FPLX 000221 HDAC_I +HGNC 14063 HDAC4 isa FPLX 000222 HDAC_II +HGNC 14068 HDAC5 isa FPLX 000222 HDAC_II +HGNC 14067 HDAC7 isa FPLX 000222 HDAC_II +HGNC 14065 HDAC9 isa FPLX 000222 HDAC_II +HGNC 14064 HDAC6 isa FPLX 000222 HDAC_II +HGNC 18128 HDAC10 isa FPLX 000222 HDAC_II +HGNC 14929 SIRT1 isa FPLX 000223 HDAC_III +HGNC 10886 SIRT2 isa FPLX 000223 HDAC_III +HGNC 14931 SIRT3 isa FPLX 000223 HDAC_III +HGNC 14932 SIRT4 isa FPLX 000223 HDAC_III +HGNC 14933 SIRT5 isa FPLX 000223 HDAC_III +HGNC 14934 SIRT6 isa FPLX 000223 HDAC_III +HGNC 14935 SIRT7 isa FPLX 000223 HDAC_III +HGNC 19086 HDAC11 isa FPLX 000224 HDAC_IV +FPLX 000221 HDAC_I isa FPLX 000220 HDAC +FPLX 000222 HDAC_II isa FPLX 000220 HDAC +FPLX 000223 HDAC_III isa FPLX 000220 HDAC +FPLX 000224 HDAC_IV isa FPLX 000220 HDAC +HGNC 4910 HIF1A partof FPLX 000230 HIF1 +HGNC 700 ARNT partof FPLX 000230 HIF1 +HGNC 4910 HIF1A isa FPLX 000231 HIF_alpha +HGNC 3374 EPAS1 isa FPLX 000231 HIF_alpha +HGNC 15825 HIF3A isa FPLX 000231 HIF_alpha +HGNC 700 ARNT isa FPLX 000232 HIF_beta +HGNC 16876 ARNT2 isa FPLX 000232 HIF_beta +HGNC 701 ARNTL isa FPLX 000232 HIF_beta +FPLX 000231 HIF_alpha partof FPLX 000229 HIF +FPLX 000232 HIF_beta partof FPLX 000229 HIF +FPLX 000242 HSP90A isa FPLX 000241 HSP90 +FPLX 000243 HSP90AA isa FPLX 000242 HSP90A +HGNC 5253 HSP90AA1 isa FPLX 000243 HSP90AA +HGNC 5258 HSP90AB1 isa FPLX 000242 HSP90A +HGNC 12028 HSP90B1 isa FPLX 000241 HSP90 +HGNC 16264 TRAP1 isa FPLX 000241 HSP90 +FPLX 000234 Histone_H1 isa FPLX 000233 Histone +FPLX 000235 Histone_H2A isa FPLX 000233 Histone +FPLX 000236 Histone_H2B isa FPLX 000233 Histone +FPLX 000237 Histone_H3 isa FPLX 000233 Histone +FPLX 000238 Histone_H4 isa FPLX 000233 Histone +HGNC 4714 H1F0 isa FPLX 000234 Histone_H1 +HGNC 18463 H1FOO isa FPLX 000234 Histone_H1 +HGNC 4722 H1FX isa FPLX 000234 Histone_H1 +HGNC 4715 HIST1H1A isa FPLX 000234 Histone_H1 +HGNC 4719 HIST1H1B isa FPLX 000234 Histone_H1 +HGNC 4716 HIST1H1C isa FPLX 000234 Histone_H1 +HGNC 4717 HIST1H1D isa FPLX 000234 Histone_H1 +HGNC 4718 HIST1H1E isa FPLX 000234 Histone_H1 +HGNC 4720 HIST1H1T isa FPLX 000234 Histone_H1 +HGNC 24893 H1FNT isa FPLX 000234 Histone_H1 +UP H2A1_HUMAN P0C0S8 isa FPLX 000235 Histone_H2A +HGNC 22516 H2AFB1 isa FPLX 000235 Histone_H2A +UP H2AB1_HUMAN P0C5Y9 isa FPLX 000235 Histone_H2A +HGNC 14456 H2AFJ isa FPLX 000235 Histone_H2A +HGNC 20664 H2AFV isa FPLX 000235 Histone_H2A +HGNC 4739 H2AFX isa FPLX 000235 Histone_H2A +HGNC 4740 H2AFY isa FPLX 000235 Histone_H2A +HGNC 14453 H2AFY2 isa FPLX 000235 Histone_H2A +HGNC 4741 H2AFZ isa FPLX 000235 Histone_H2A +HGNC 18729 HIST1H2AA isa FPLX 000235 Histone_H2A +HGNC 4733 HIST1H2AC isa FPLX 000235 Histone_H2A +HGNC 4729 HIST1H2AD isa FPLX 000235 Histone_H2A +HGNC 13671 HIST1H2AH isa FPLX 000235 Histone_H2A +HGNC 4727 HIST1H2AJ isa FPLX 000235 Histone_H2A +HGNC 20508 HIST2H2AB isa FPLX 000235 Histone_H2A +HGNC 4738 HIST2H2AC isa FPLX 000235 Histone_H2A +HGNC 20507 HIST3H2A isa FPLX 000235 Histone_H2A +UP H2A1B_HUMAN P04908 isa FPLX 000235 Histone_H2A +UP H2A2A_HUMAN Q6FI13 isa FPLX 000235 Histone_H2A +UP H2B1C_HUMAN P62807 isa FPLX 000236 Histone_H2B +HGNC 18730 HIST1H2BA isa FPLX 000236 Histone_H2B +HGNC 4751 HIST1H2BB isa FPLX 000236 Histone_H2B +HGNC 4747 HIST1H2BD isa FPLX 000236 Histone_H2B +HGNC 4755 HIST1H2BH isa FPLX 000236 Histone_H2B +HGNC 4761 HIST1H2BJ isa FPLX 000236 Histone_H2B +HGNC 13954 HIST1H2BK isa FPLX 000236 Histone_H2B +HGNC 4748 HIST1H2BL isa FPLX 000236 Histone_H2B +HGNC 4750 HIST1H2BM isa FPLX 000236 Histone_H2B +HGNC 4749 HIST1H2BN isa FPLX 000236 Histone_H2B +HGNC 4758 HIST1H2BO isa FPLX 000236 Histone_H2B +HGNC 20516 HIST2H2BC isa FPLX 000236 Histone_H2B +HGNC 20517 HIST2H2BD isa FPLX 000236 Histone_H2B +HGNC 4760 HIST2H2BE isa FPLX 000236 Histone_H2B +HGNC 24700 HIST2H2BF isa FPLX 000236 Histone_H2B +HGNC 20514 HIST3H2BB isa FPLX 000236 Histone_H2B +HGNC 4762 H2BFS isa FPLX 000236 Histone_H2B +HGNC 27867 H2BFM isa FPLX 000236 Histone_H2B +HGNC 27252 H2BFWT isa FPLX 000236 Histone_H2B +UP H31_HUMAN P68431 isa FPLX 000237 Histone_H3 +UP H32_HUMAN Q71DI3 isa FPLX 000237 Histone_H3 +HGNC 4778 HIST3H3 isa FPLX 000237 Histone_H3 +UP H33_HUMAN P84243 isa FPLX 000237 Histone_H3 +HGNC 33164 H3F3C isa FPLX 000237 Histone_H3 +UP H4_HUMAN P62805 isa FPLX 000238 Histone_H4 +HGNC 4792 HIST1H4G isa FPLX 000238 Histone_H4 +HGNC 11362 STAT1 isa FPLX 000453 STAT +HGNC 11363 STAT2 isa FPLX 000453 STAT +HGNC 11364 STAT3 isa FPLX 000453 STAT +HGNC 11365 STAT4 isa FPLX 000453 STAT +HGNC 11366 STAT5A isa FPLX 000454 STAT5 +HGNC 11367 STAT5B isa FPLX 000454 STAT5 +HGNC 11368 STAT6 isa FPLX 000453 STAT +FPLX 000454 STAT5 isa FPLX 000453 STAT +HGNC 8799 PDGFA isa FPLX 000342 PDGF +HGNC 8800 PDGFB isa FPLX 000342 PDGF +HGNC 8801 PDGFC isa FPLX 000342 PDGF +HGNC 30620 PDGFD isa FPLX 000342 PDGF +HGNC 8799 PDGFA partof FPLX 000347 PDGF_AA +HGNC 8799 PDGFA partof FPLX 000348 PDGF_AB +HGNC 8800 PDGFB partof FPLX 000348 PDGF_AB +HGNC 8800 PDGFB partof FPLX 000349 PDGF_BB +HGNC 8801 PDGFC partof FPLX 000350 PDGF_CC +HGNC 30620 PDGFD partof FPLX 000351 PDGF_DD +HGNC 8803 PDGFRA isa FPLX 000343 PDGFR +HGNC 8804 PDGFRB isa FPLX 000343 PDGFR +HGNC 8803 PDGFRA partof FPLX 000344 PDGFR_AA +HGNC 8803 PDGFRA partof FPLX 000345 PDGFR_AB +HGNC 8804 PDGFRB partof FPLX 000345 PDGFR_AB +HGNC 8804 PDGFRB partof FPLX 000346 PDGFR_BB +HGNC 4389 GNAO1 isa FPLX 000213 G_i_alpha +HGNC 4384 GNAI1 isa FPLX 000213 G_i_alpha +HGNC 4385 GNAI2 isa FPLX 000213 G_i_alpha +HGNC 4387 GNAI3 isa FPLX 000213 G_i_alpha +HGNC 4393 GNAT1 isa FPLX 000213 G_i_alpha +HGNC 4394 GNAT2 isa FPLX 000213 G_i_alpha +HGNC 22800 GNAT3 isa FPLX 000213 G_i_alpha +HGNC 4395 GNAZ isa FPLX 000213 G_i_alpha +HGNC 4392 GNAS isa FPLX 000218 G_s_alpha +HGNC 4388 GNAL isa FPLX 000218 G_s_alpha +HGNC 4390 GNAQ isa FPLX 000216 G_q_alpha +HGNC 4379 GNA11 isa FPLX 000216 G_q_alpha +HGNC 4382 GNA14 isa FPLX 000216 G_q_alpha +HGNC 4383 GNA15 isa FPLX 000216 G_q_alpha +HGNC 4380 GNA12 isa FPLX 000208 G_12_alpha +HGNC 4381 GNA13 isa FPLX 000208 G_12_alpha +FPLX 000213 G_i_alpha isa FPLX 000209 G_alpha +FPLX 000218 G_s_alpha isa FPLX 000209 G_alpha +FPLX 000216 G_q_alpha isa FPLX 000209 G_alpha +FPLX 000208 G_12_alpha isa FPLX 000209 G_alpha +FPLX 000213 G_i_alpha partof FPLX 000212 G_i +FPLX 000218 G_s_alpha partof FPLX 000217 G_s +FPLX 000216 G_q_alpha partof FPLX 000215 G_q +FPLX 000208 G_12_alpha partof FPLX 000207 G_12 +FPLX 000212 G_i isa FPLX 000214 G_protein +FPLX 000217 G_s isa FPLX 000214 G_protein +FPLX 000215 G_q isa FPLX 000214 G_protein +FPLX 000207 G_12 isa FPLX 000214 G_protein +HGNC 19989 ANAPC2 partof FPLX 000050 APC_C +HGNC 14452 ANAPC11 partof FPLX 000050 APC_C +HGNC 19988 ANAPC1 partof FPLX 000050 APC_C +HGNC 1720 CDC16 partof FPLX 000050 APC_C +HGNC 1728 CDC27 partof FPLX 000050 APC_C +HGNC 1724 CDC23 partof FPLX 000050 APC_C +HGNC 15713 ANAPC5 partof FPLX 000050 APC_C +HGNC 24077 ANAPC10 partof FPLX 000050 APC_C +HGNC 24531 ANAPC15 partof FPLX 000050 APC_C +HGNC 24540 ANAPC13 partof FPLX 000050 APC_C +HGNC 17839 CDC26 partof FPLX 000050 APC_C +HGNC 26976 ANAPC16 partof FPLX 000050 APC_C +HGNC 17380 ANAPC7 partof FPLX 000050 APC_C +HGNC 19990 ANAPC4 partof FPLX 000050 APC_C +HGNC 3236 EGFR isa FPLX 000160 ERBB +HGNC 3430 ERBB2 isa FPLX 000160 ERBB +HGNC 3431 ERBB3 isa FPLX 000160 ERBB +HGNC 3432 ERBB4 isa FPLX 000160 ERBB +HGNC 3296 EIF4G1 isa FPLX 000155 EIF4G +HGNC 3297 EIF4G2 isa FPLX 000155 EIF4G +HGNC 3298 EIF4G3 isa FPLX 000155 EIF4G +HGNC 7775 NFATC1 isa FPLX 000309 NFAT +HGNC 7776 NFATC2 isa FPLX 000309 NFAT +HGNC 7777 NFATC3 isa FPLX 000309 NFAT +HGNC 7778 NFATC4 isa FPLX 000309 NFAT +HGNC 7774 NFAT5 isa FPLX 000309 NFAT +HGNC 4706 GYS1 isa FPLX 000206 GYS +HGNC 4707 GYS2 isa FPLX 000206 GYS +HGNC 20766 TUBA1A isa FPLX 000483 TUBA +HGNC 18809 TUBA1B isa FPLX 000483 TUBA +HGNC 20768 TUBA1C isa FPLX 000483 TUBA +HGNC 12408 TUBA3C isa FPLX 000483 TUBA +HGNC 24071 TUBA3D isa FPLX 000483 TUBA +HGNC 20765 TUBA3E isa FPLX 000483 TUBA +HGNC 12407 TUBA4A isa FPLX 000483 TUBA +HGNC 12410 TUBA8 isa FPLX 000483 TUBA +HGNC 23534 TUBAL3 isa FPLX 000483 TUBA +HGNC 20778 TUBB isa FPLX 000484 TUBB +HGNC 16257 TUBB1 isa FPLX 000484 TUBB +HGNC 12412 TUBB2A isa FPLX 000484 TUBB +HGNC 30829 TUBB2B isa FPLX 000484 TUBB +HGNC 20772 TUBB3 isa FPLX 000484 TUBB +HGNC 20774 TUBB4A isa FPLX 000484 TUBB +HGNC 20771 TUBB4B isa FPLX 000484 TUBB +HGNC 20776 TUBB6 isa FPLX 000484 TUBB +HGNC 12417 TUBG1 isa FPLX 000485 TUBG +HGNC 12419 TUBG2 isa FPLX 000485 TUBG +FPLX 000483 TUBA isa FPLX 000486 Tubulin +FPLX 000484 TUBB isa FPLX 000486 Tubulin +FPLX 000485 TUBG isa FPLX 000486 Tubulin +HGNC 16811 TUBD1 isa FPLX 000486 Tubulin +HGNC 20775 TUBE1 isa FPLX 000486 Tubulin +HGNC 6190 JAK1 isa FPLX 000266 JAK +HGNC 6192 JAK2 isa FPLX 000266 JAK +HGNC 6193 JAK3 isa FPLX 000266 JAK +HGNC 12440 TYK2 isa FPLX 000266 JAK +HGNC 1706 CD8A isa FPLX 000090 CD8 +HGNC 1707 CD8B isa FPLX 000090 CD8 +HGNC 6535 LDHA isa FPLX 000275 LDH +HGNC 6541 LDHB isa FPLX 000275 LDH +HGNC 6544 LDHC isa FPLX 000275 LDH +HGNC 10430 RPS6KA1 isa FPLX 000329 P90RSK +HGNC 10431 RPS6KA2 isa FPLX 000329 P90RSK +HGNC 10432 RPS6KA3 isa FPLX 000329 P90RSK +HGNC 10433 RPS6KA4 isa FPLX 000329 P90RSK +HGNC 10434 RPS6KA5 isa FPLX 000329 P90RSK +HGNC 10435 RPS6KA6 isa FPLX 000329 P90RSK +HGNC 10436 RPS6KB1 isa FPLX 000328 P70S6K +HGNC 10437 RPS6KB2 isa FPLX 000328 P70S6K +FPLX 000329 P90RSK isa FPLX 000422 RSK +FPLX 000328 P70S6K isa FPLX 000422 RSK +HGNC 9955 RELA isa FPLX 000313 NFkappaB_2 +HGNC 9956 RELB isa FPLX 000313 NFkappaB_2 +HGNC 9954 REL isa FPLX 000313 NFkappaB_2 +HGNC 7794 NFKB1 isa FPLX 000312 NFkappaB_1 +HGNC 7795 NFKB2 isa FPLX 000312 NFkappaB_1 +FPLX 000312 NFkappaB_1 partof FPLX 000311 NFkappaB +FPLX 000313 NFkappaB_2 partof FPLX 000311 NFkappaB +HGNC 11847 TLR1 isa FPLX 000472 TLR +HGNC 11848 TLR2 isa FPLX 000472 TLR +HGNC 11849 TLR3 isa FPLX 000472 TLR +HGNC 11850 TLR4 isa FPLX 000472 TLR +HGNC 11851 TLR5 isa FPLX 000472 TLR +HGNC 16711 TLR6 isa FPLX 000472 TLR +HGNC 15631 TLR7 isa FPLX 000472 TLR +HGNC 15632 TLR8 isa FPLX 000472 TLR +HGNC 15633 TLR9 isa FPLX 000472 TLR +HGNC 15634 TLR10 isa FPLX 000472 TLR +HGNC 11110 ARID1A partof FPLX 000457 SWI_SNF +HGNC 18040 ARID1B partof FPLX 000457 SWI_SNF +HGNC 11097 SMARCA1 partof FPLX 000457 SWI_SNF +HGNC 11098 SMARCA2 partof FPLX 000457 SWI_SNF +HGNC 11100 SMARCA4 partof FPLX 000457 SWI_SNF +HGNC 11101 SMARCA5 partof FPLX 000457 SWI_SNF +HGNC 11103 SMARCB1 partof FPLX 000457 SWI_SNF +HGNC 11104 SMARCC1 partof FPLX 000457 SWI_SNF +HGNC 11105 SMARCC2 partof FPLX 000457 SWI_SNF +HGNC 11106 SMARCD1 partof FPLX 000457 SWI_SNF +HGNC 11107 SMARCD2 partof FPLX 000457 SWI_SNF +HGNC 11108 SMARCD3 partof FPLX 000457 SWI_SNF +HGNC 11109 SMARCE1 partof FPLX 000457 SWI_SNF +HGNC 24124 ACTL6A partof FPLX 000457 SWI_SNF +HGNC 160 ACTL6B partof FPLX 000457 SWI_SNF +HGNC 11099 HLTF partof FPLX 000457 SWI_SNF +HGNC 1067 BMP1 isa FPLX 000067 BMP +HGNC 1069 BMP2 isa FPLX 000067 BMP +HGNC 1070 BMP3 isa FPLX 000067 BMP +HGNC 1071 BMP4 isa FPLX 000067 BMP +HGNC 1072 BMP5 isa FPLX 000067 BMP +HGNC 1073 BMP6 isa FPLX 000067 BMP +HGNC 1074 BMP7 isa FPLX 000067 BMP +HGNC 21650 BMP8A isa FPLX 000067 BMP +HGNC 1075 BMP8B isa FPLX 000067 BMP +HGNC 20869 BMP10 isa FPLX 000067 BMP +HGNC 1068 BMP15 isa FPLX 000067 BMP +HGNC 5969 IL12A isa FPLX 000253 IL12 +HGNC 5970 IL12B isa FPLX 000253 IL12 +HGNC 5991 IL1A isa FPLX 000252 IL1 +HGNC 5992 IL1B isa FPLX 000252 IL1 +HGNC 11179 SOD1 isa FPLX 000447 SOD +HGNC 11180 SOD2 isa FPLX 000447 SOD +HGNC 11181 SOD3 isa FPLX 000447 SOD +HGNC 12362 TSC1 isa FPLX 000482 TSC +HGNC 12363 TSC2 isa FPLX 000482 TSC +HGNC 3819 FOXO1 isa FPLX 000174 FOXO +HGNC 3821 FOXO3 isa FPLX 000174 FOXO +HGNC 7139 FOXO4 isa FPLX 000174 FOXO +HGNC 24814 FOXO6 isa FPLX 000174 FOXO +HGNC 7155 MMP1 isa FPLX 000291 MMP +HGNC 7166 MMP2 isa FPLX 000291 MMP +HGNC 7173 MMP3 isa FPLX 000291 MMP +HGNC 7174 MMP7 isa FPLX 000291 MMP +HGNC 7175 MMP8 isa FPLX 000291 MMP +HGNC 7176 MMP9 isa FPLX 000291 MMP +HGNC 7156 MMP10 isa FPLX 000291 MMP +HGNC 7157 MMP11 isa FPLX 000291 MMP +HGNC 7158 MMP12 isa FPLX 000291 MMP +HGNC 7159 MMP13 isa FPLX 000291 MMP +HGNC 7160 MMP14 isa FPLX 000291 MMP +HGNC 7161 MMP15 isa FPLX 000291 MMP +HGNC 7162 MMP16 isa FPLX 000291 MMP +HGNC 7163 MMP17 isa FPLX 000291 MMP +HGNC 7165 MMP19 isa FPLX 000291 MMP +HGNC 7167 MMP20 isa FPLX 000291 MMP +HGNC 14357 MMP21 isa FPLX 000291 MMP +HGNC 7171 MMP23B isa FPLX 000291 MMP +HGNC 7172 MMP24 isa FPLX 000291 MMP +HGNC 14246 MMP25 isa FPLX 000291 MMP +HGNC 14249 MMP26 isa FPLX 000291 MMP +HGNC 14250 MMP27 isa FPLX 000291 MMP +HGNC 14366 MMP28 isa FPLX 000291 MMP +HGNC 84 ACACA partof FPLX 000005 ACC +HGNC 85 ACACB partof FPLX 000005 ACC +HGNC 6838 MAP1LC3A isa FPLX 000280 MAP1LC3 +HGNC 13352 MAP1LC3B isa FPLX 000280 MAP1LC3 +HGNC 34390 MAP1LC3B2 isa FPLX 000280 MAP1LC3 +HGNC 13353 MAP1LC3C isa FPLX 000280 MAP1LC3 +HGNC 5417 IFNA1 isa FPLX 000246 IFNA +HGNC 5423 IFNA2 isa FPLX 000246 IFNA +HGNC 5425 IFNA4 isa FPLX 000246 IFNA +HGNC 5426 IFNA5 isa FPLX 000246 IFNA +HGNC 5427 IFNA6 isa FPLX 000246 IFNA +HGNC 5428 IFNA7 isa FPLX 000246 IFNA +HGNC 5429 IFNA8 isa FPLX 000246 IFNA +HGNC 5418 IFNA10 isa FPLX 000246 IFNA +HGNC 5419 IFNA13 isa FPLX 000246 IFNA +HGNC 5420 IFNA14 isa FPLX 000246 IFNA +HGNC 5421 IFNA16 isa FPLX 000246 IFNA +HGNC 5422 IFNA17 isa FPLX 000246 IFNA +HGNC 5424 IFNA21 isa FPLX 000246 IFNA +HGNC 5434 IFNB1 isa FPLX 000247 IFNB +FPLX 000246 IFNA isa FPLX 000262 Interferon +FPLX 000247 IFNB isa FPLX 000262 Interferon +HGNC 21714 IFNK isa FPLX 000262 Interferon +HGNC 5448 IFNW1 isa FPLX 000262 Interferon +HGNC 11916 TNFRSF1A isa FPLX 000137 Death_receptor +HGNC 11917 TNFRSF1B isa FPLX 000137 Death_receptor +HGNC 11904 TNFRSF10A isa FPLX 000137 Death_receptor +HGNC 11905 TNFRSF10B isa FPLX 000137 Death_receptor +HGNC 11906 TNFRSF10C isa FPLX 000137 Death_receptor +HGNC 11907 TNFRSF10D isa FPLX 000137 Death_receptor +HGNC 11920 FAS isa FPLX 000137 Death_receptor +HGNC 11916 TNFRSF1A isa FPLX 000475 TNFRSF +HGNC 11917 TNFRSF1B isa FPLX 000475 TNFRSF +HGNC 11918 TNFRSF4 isa FPLX 000475 TNFRSF +HGNC 11923 TNFRSF8 isa FPLX 000475 TNFRSF +HGNC 11924 TNFRSF9 isa FPLX 000475 TNFRSF +HGNC 11904 TNFRSF10A isa FPLX 000475 TNFRSF +HGNC 11905 TNFRSF10B isa FPLX 000475 TNFRSF +HGNC 11906 TNFRSF10C isa FPLX 000475 TNFRSF +HGNC 11907 TNFRSF10D isa FPLX 000475 TNFRSF +HGNC 11908 TNFRSF11A isa FPLX 000475 TNFRSF +HGNC 11909 TNFRSF11B isa FPLX 000475 TNFRSF +HGNC 18152 TNFRSF12A isa FPLX 000475 TNFRSF +HGNC 18153 TNFRSF13B isa FPLX 000475 TNFRSF +HGNC 17755 TNFRSF13C isa FPLX 000475 TNFRSF +HGNC 11912 TNFRSF14 isa FPLX 000475 TNFRSF +HGNC 11913 TNFRSF17 isa FPLX 000475 TNFRSF +HGNC 11914 TNFRSF18 isa FPLX 000475 TNFRSF +HGNC 11915 TNFRSF19 isa FPLX 000475 TNFRSF +HGNC 13469 TNFRSF21 isa FPLX 000475 TNFRSF +HGNC 11910 TNFRSF25 isa FPLX 000475 TNFRSF +HGNC 3665 FGF1 isa FPLX 000167 FGF +HGNC 3676 FGF2 isa FPLX 000167 FGF +HGNC 3681 FGF3 isa FPLX 000167 FGF +HGNC 3682 FGF4 isa FPLX 000167 FGF +HGNC 3683 FGF5 isa FPLX 000167 FGF +HGNC 3684 FGF6 isa FPLX 000167 FGF +HGNC 3685 FGF7 isa FPLX 000167 FGF +HGNC 3686 FGF8 isa FPLX 000167 FGF +HGNC 3687 FGF9 isa FPLX 000167 FGF +HGNC 3666 FGF10 isa FPLX 000167 FGF +HGNC 3667 FGF11 isa FPLX 000167 FGF +HGNC 3668 FGF12 isa FPLX 000167 FGF +HGNC 3670 FGF13 isa FPLX 000167 FGF +HGNC 3671 FGF14 isa FPLX 000167 FGF +HGNC 3672 FGF16 isa FPLX 000167 FGF +HGNC 3673 FGF17 isa FPLX 000167 FGF +HGNC 3674 FGF18 isa FPLX 000167 FGF +HGNC 3675 FGF19 isa FPLX 000167 FGF +HGNC 3677 FGF20 isa FPLX 000167 FGF +HGNC 3678 FGF21 isa FPLX 000167 FGF +HGNC 3679 FGF22 isa FPLX 000167 FGF +HGNC 3680 FGF23 isa FPLX 000167 FGF +HGNC 12774 WNT1 isa FPLX 000497 Wnt +HGNC 12780 WNT2 isa FPLX 000497 Wnt +HGNC 12781 WNT2B isa FPLX 000497 Wnt +HGNC 12782 WNT3 isa FPLX 000497 Wnt +HGNC 15983 WNT3A isa FPLX 000497 Wnt +HGNC 12783 WNT4 isa FPLX 000497 Wnt +HGNC 12784 WNT5A isa FPLX 000497 Wnt +HGNC 16265 WNT5B isa FPLX 000497 Wnt +HGNC 12785 WNT6 isa FPLX 000497 Wnt +HGNC 12786 WNT7A isa FPLX 000497 Wnt +HGNC 12787 WNT7B isa FPLX 000497 Wnt +HGNC 12788 WNT8A isa FPLX 000497 Wnt +HGNC 12789 WNT8B isa FPLX 000497 Wnt +HGNC 12778 WNT9A isa FPLX 000497 Wnt +HGNC 12779 WNT9B isa FPLX 000497 Wnt +HGNC 13829 WNT10A isa FPLX 000497 Wnt +HGNC 12775 WNT10B isa FPLX 000497 Wnt +HGNC 12776 WNT11 isa FPLX 000497 Wnt +HGNC 16267 WNT16 isa FPLX 000497 Wnt +HGNC 646 ARAF isa FPLX 000399 RAF +HGNC 1097 BRAF isa FPLX 000399 RAF +HGNC 9829 RAF1 isa FPLX 000399 RAF +FPLX 000399 RAF isa FPLX 000282 MAP3K +HGNC 6848 MAP3K1 isa FPLX 000282 MAP3K +HGNC 6854 MAP3K2 isa FPLX 000282 MAP3K +HGNC 6855 MAP3K3 isa FPLX 000282 MAP3K +HGNC 6856 MAP3K4 isa FPLX 000282 MAP3K +HGNC 6857 MAP3K5 isa FPLX 000282 MAP3K +HGNC 6858 MAP3K6 isa FPLX 000282 MAP3K +HGNC 6859 MAP3K7 isa FPLX 000282 MAP3K +HGNC 6860 MAP3K8 isa FPLX 000282 MAP3K +HGNC 6861 MAP3K9 isa FPLX 000282 MAP3K +HGNC 6849 MAP3K10 isa FPLX 000282 MAP3K +HGNC 6850 MAP3K11 isa FPLX 000282 MAP3K +HGNC 6851 MAP3K12 isa FPLX 000282 MAP3K +HGNC 6852 MAP3K13 isa FPLX 000282 MAP3K +HGNC 6853 MAP3K14 isa FPLX 000282 MAP3K +HGNC 31689 MAP3K15 isa FPLX 000282 MAP3K +FPLX 000458 TAOK isa FPLX 000282 MAP3K +HGNC 29259 TAOK1 isa FPLX 000458 TAOK +HGNC 16835 TAOK2 isa FPLX 000458 TAOK +HGNC 18133 TAOK3 isa FPLX 000458 TAOK +HGNC 26249 MAP3K19 isa FPLX 000282 MAP3K +HGNC 17797 MAP3K20 isa FPLX 000282 MAP3K +HGNC 29798 MAP3K21 isa FPLX 000282 MAP3K +HGNC 1100 BRCA1 isa FPLX 000071 BRCA +HGNC 1101 BRCA2 isa FPLX 000071 BRCA +HGNC 19700 CNKSR1 isa FPLX 000106 CNKSR +HGNC 19701 CNKSR2 isa FPLX 000106 CNKSR +HGNC 3064 DUSP1 isa FPLX 000144 DUSP +HGNC 3068 DUSP2 isa FPLX 000144 DUSP +HGNC 3069 DUSP3 isa FPLX 000144 DUSP +HGNC 3070 DUSP4 isa FPLX 000144 DUSP +HGNC 3071 DUSP5 isa FPLX 000144 DUSP +HGNC 3072 DUSP6 isa FPLX 000144 DUSP +HGNC 3488 ETS1 isa FPLX 000163 ETS +HGNC 3489 ETS2 isa FPLX 000163 ETS +HGNC 30380 EXOC1 partof FPLX 000164 EXOC +HGNC 24968 EXOC2 partof FPLX 000164 EXOC +HGNC 30378 EXOC3 partof FPLX 000164 EXOC +HGNC 30389 EXOC4 partof FPLX 000164 EXOC +HGNC 10696 EXOC5 partof FPLX 000164 EXOC +HGNC 23196 EXOC6 partof FPLX 000164 EXOC +HGNC 23214 EXOC7 partof FPLX 000164 EXOC +HGNC 24659 EXOC8 partof FPLX 000164 EXOC +HGNC 3582 FANCA isa FPLX 000166 FANC +HGNC 3583 FANCB isa FPLX 000166 FANC +HGNC 3584 FANCC isa FPLX 000166 FANC +HGNC 1101 BRCA2 isa FPLX 000166 FANC +HGNC 3585 FANCD2 isa FPLX 000166 FANC +HGNC 3586 FANCE isa FPLX 000166 FANC +HGNC 3587 FANCF isa FPLX 000166 FANC +HGNC 3588 FANCG isa FPLX 000166 FANC +HGNC 25568 FANCI isa FPLX 000166 FANC +HGNC 20473 BRIP1 isa FPLX 000166 FANC +HGNC 20748 FANCL isa FPLX 000166 FANC +HGNC 23168 FANCM isa FPLX 000166 FANC +HGNC 26144 PALB2 isa FPLX 000166 FANC +HGNC 9820 RAD51C isa FPLX 000166 FANC +HGNC 23845 SLX4 isa FPLX 000166 FANC +HGNC 3436 ERCC4 isa FPLX 000166 FANC +HGNC 9817 RAD51 isa FPLX 000166 FANC +HGNC 1100 BRCA1 isa FPLX 000166 FANC +HGNC 25009 UBE2T isa FPLX 000166 FANC +HGNC 12829 XRCC2 isa FPLX 000166 FANC +HGNC 3782 FNTA partof FPLX 000172 FNT +HGNC 3785 FNTB partof FPLX 000172 FNT +HGNC 6407 KRAS isa FPLX 000404 RAS +HGNC 5173 HRAS isa FPLX 000404 RAS +HGNC 7989 NRAS isa FPLX 000404 RAS +HGNC 6465 KSR1 isa FPLX 000272 KSR +HGNC 18610 KSR2 isa FPLX 000272 KSR +HGNC 6840 MAP2K1 isa FPLX 000286 MEK +HGNC 6842 MAP2K2 isa FPLX 000286 MEK +FPLX 000286 MEK isa FPLX 000281 MAP2K +HGNC 6843 MAP2K3 isa FPLX 000281 MAP2K +HGNC 6844 MAP2K4 isa FPLX 000281 MAP2K +HGNC 6845 MAP2K5 isa FPLX 000281 MAP2K +HGNC 6846 MAP2K6 isa FPLX 000281 MAP2K +HGNC 6847 MAP2K7 isa FPLX 000281 MAP2K +HGNC 6944 MCM2 isa FPLX 000284 MCM +HGNC 6945 MCM3 isa FPLX 000284 MCM +HGNC 6947 MCM4 isa FPLX 000284 MCM +HGNC 6948 MCM5 isa FPLX 000284 MCM +HGNC 6949 MCM6 isa FPLX 000284 MCM +HGNC 6950 MCM7 isa FPLX 000284 MCM +HGNC 16147 MCM8 isa FPLX 000284 MCM +HGNC 21484 MCM9 isa FPLX 000284 MCM +HGNC 26368 MCMDC2 isa FPLX 000284 MCM +HGNC 8590 PAK1 isa FPLX 000330 PAK +HGNC 8591 PAK2 isa FPLX 000330 PAK +HGNC 8592 PAK3 isa FPLX 000330 PAK +HGNC 16059 PAK4 isa FPLX 000330 PAK +HGNC 15916 PAK5 isa FPLX 000330 PAK +HGNC 16061 PAK6 isa FPLX 000330 PAK +HGNC 9801 RAC1 isa FPLX 000398 RAC +HGNC 9802 RAC2 isa FPLX 000398 RAC +HGNC 9803 RAC3 isa FPLX 000398 RAC +HGNC 672 RHOG isa FPLX 000398 RAC +HGNC 9839 RALA isa FPLX 000400 RAL +HGNC 9840 RALB isa FPLX 000400 RAL +HGNC 4568 RAPGEF1 isa FPLX 000402 RAPGEF +HGNC 16854 RAPGEF2 isa FPLX 000402 RAPGEF +HGNC 9871 RASA1 isa FPLX 000405 RASA +HGNC 9872 RASA2 isa FPLX 000405 RASA +HGNC 20331 RASA3 isa FPLX 000405 RASA +HGNC 9873 RASAL1 isa FPLX 000406 RASAL +HGNC 9874 RASAL2 isa FPLX 000406 RASAL +HGNC 26129 RASAL3 isa FPLX 000406 RASAL +HGNC 9875 RASGRF1 isa FPLX 000408 RASGRF +HGNC 9876 RASGRF2 isa FPLX 000408 RASGRF +HGNC 9878 RASGRP1 isa FPLX 000409 RASGRP +HGNC 9879 RASGRP2 isa FPLX 000409 RASGRP +HGNC 14545 RASGRP3 isa FPLX 000409 RASGRP +HGNC 18958 RASGRP4 isa FPLX 000409 RASGRP +HGNC 9882 RASSF1 isa FPLX 000410 RASSF +HGNC 9883 RASSF2 isa FPLX 000410 RASSF +HGNC 14271 RASSF3 isa FPLX 000410 RASSF +HGNC 20793 RASSF4 isa FPLX 000410 RASSF +HGNC 17609 RASSF5 isa FPLX 000410 RASSF +HGNC 20796 RASSF6 isa FPLX 000410 RASSF +HGNC 1166 RASSF7 isa FPLX 000410 RASSF +HGNC 13232 RASSF8 isa FPLX 000410 RASSF +HGNC 15739 RASSF9 isa FPLX 000410 RASSF +HGNC 33984 RASSF10 isa FPLX 000410 RASSF +HGNC 30281 RGL1 isa FPLX 000413 RGL +HGNC 9769 RGL2 isa FPLX 000413 RGL +HGNC 30282 RGL3 isa FPLX 000413 RGL +HGNC 667 RHOA isa FPLX 000414 RHO +HGNC 668 RHOB isa FPLX 000414 RHO +HGNC 669 RHOC isa FPLX 000414 RHO +HGNC 10251 ROCK1 isa FPLX 000419 ROCK +HGNC 10252 ROCK2 isa FPLX 000419 ROCK +HGNC 10840 SHC1 isa FPLX 000432 SHC +HGNC 29869 SHC2 isa FPLX 000432 SHC +HGNC 18181 SHC3 isa FPLX 000432 SHC +HGNC 16743 SHC4 isa FPLX 000432 SHC +HGNC 11187 SOS1 isa FPLX 000448 SOS +HGNC 11188 SOS2 isa FPLX 000448 SOS +HGNC 11269 SPRY1 isa FPLX 000450 SPRY +HGNC 11270 SPRY2 isa FPLX 000450 SPRY +HGNC 11271 SPRY3 isa FPLX 000450 SPRY +HGNC 15533 SPRY4 isa FPLX 000450 SPRY +HGNC 11749 TFDP1 isa FPLX 000464 TFDP +HGNC 11751 TFDP2 isa FPLX 000464 TFDP +HGNC 11805 TIAM1 isa FPLX 000470 TIAM +HGNC 11806 TIAM2 isa FPLX 000470 TIAM +HGNC 20249 SPRED1 isa FPLX 000449 SPRED +HGNC 17722 SPRED2 isa FPLX 000449 SPRED +HGNC 31041 SPRED3 isa FPLX 000449 SPRED +HGNC 1885 CGA partof FPLX 000219 hCG +HGNC 1886 CGB3 partof FPLX 000219 hCG +HGNC 10513 SAA1 isa FPLX 000428 SAA +HGNC 10514 SAA2 isa FPLX 000428 SAA +HGNC 10516 SAA4 isa FPLX 000428 SAA +HGNC 6873 MAPK11 isa FPLX 000326 p38 +HGNC 6874 MAPK12 isa FPLX 000326 p38 +HGNC 6875 MAPK13 isa FPLX 000326 p38 +HGNC 6876 MAPK14 isa FPLX 000326 p38 +FPLX 000326 p38 isa FPLX 000283 MAPK +HGNC 10773 SFN isa FPLX 000323 p14_3_3 +HGNC 12849 YWHAB isa FPLX 000323 p14_3_3 +HGNC 12851 YWHAE isa FPLX 000323 p14_3_3 +HGNC 12852 YWHAG isa FPLX 000323 p14_3_3 +HGNC 12853 YWHAH isa FPLX 000323 p14_3_3 +HGNC 12854 YWHAQ isa FPLX 000323 p14_3_3 +HGNC 12855 YWHAZ isa FPLX 000323 p14_3_3 +HGNC 59 ABCC8 isa FPLX 000456 Sulfonylurea_receptor +HGNC 60 ABCC9 isa FPLX 000456 Sulfonylurea_receptor +HGNC 87 ACAD8 isa FPLX 000004 ACAD +HGNC 21497 ACAD9 isa FPLX 000004 ACAD +HGNC 88 ACADL isa FPLX 000004 ACAD +HGNC 89 ACADM isa FPLX 000004 ACAD +HGNC 90 ACADS isa FPLX 000004 ACAD +HGNC 92 ACADVL isa FPLX 000004 ACAD +HGNC 21597 ACAD10 isa FPLX 000004 ACAD +HGNC 30211 ACAD11 isa FPLX 000004 ACAD +HGNC 91 ACADSB isa FPLX 000004 ACAD +HGNC 4189 GCDH isa FPLX 000004 ACAD +HGNC 6186 IVD isa FPLX 000004 ACAD +HGNC 10996 SLC27A2 isa FPLX 000006 Acetyl_CoA_synthetase +HGNC 3569 ACSL1 isa FPLX 000006 Acetyl_CoA_synthetase +HGNC 3570 ACSL3 isa FPLX 000006 Acetyl_CoA_synthetase +HGNC 3571 ACSL4 isa FPLX 000006 Acetyl_CoA_synthetase +HGNC 16526 ACSL5 isa FPLX 000006 Acetyl_CoA_synthetase +HGNC 16496 ACSL6 isa FPLX 000006 Acetyl_CoA_synthetase +HGNC 119 ACOX1 isa FPLX 000007 ACOX +HGNC 120 ACOX2 isa FPLX 000007 ACOX +HGNC 121 ACOX3 isa FPLX 000007 ACOX +HGNC 25621 ACOXL isa FPLX 000007 ACOX +HGNC 3569 ACSL1 isa FPLX 000008 ACSL +HGNC 3570 ACSL3 isa FPLX 000008 ACSL +HGNC 3571 ACSL4 isa FPLX 000008 ACSL +HGNC 16526 ACSL5 isa FPLX 000008 ACSL +HGNC 16496 ACSL6 isa FPLX 000008 ACSL +HGNC 163 ACTN1 isa FPLX 000014 ACTN +HGNC 164 ACTN2 isa FPLX 000014 ACTN +HGNC 165 ACTN3 isa FPLX 000014 ACTN +HGNC 166 ACTN4 isa FPLX 000014 ACTN +HGNC 232 ADCY1 isa FPLX 000017 ADCY +HGNC 233 ADCY2 isa FPLX 000017 ADCY +HGNC 234 ADCY3 isa FPLX 000017 ADCY +HGNC 235 ADCY4 isa FPLX 000017 ADCY +HGNC 236 ADCY5 isa FPLX 000017 ADCY +HGNC 237 ADCY6 isa FPLX 000017 ADCY +HGNC 238 ADCY7 isa FPLX 000017 ADCY +HGNC 239 ADCY8 isa FPLX 000017 ADCY +HGNC 240 ADCY9 isa FPLX 000017 ADCY +HGNC 21285 ADCY10 isa FPLX 000017 ADCY +HGNC 249 ADH1A isa FPLX 000018 ADH +HGNC 250 ADH1B isa FPLX 000018 ADH +HGNC 251 ADH1C isa FPLX 000018 ADH +HGNC 252 ADH4 isa FPLX 000018 ADH +HGNC 253 ADH5 isa FPLX 000018 ADH +HGNC 255 ADH6 isa FPLX 000018 ADH +HGNC 256 ADH7 isa FPLX 000018 ADH +HGNC 16354 ADHFE1 isa FPLX 000018 ADH +HGNC 277 ADRA1A isa FPLX 000019 ADRA +HGNC 278 ADRA1B isa FPLX 000019 ADRA +HGNC 280 ADRA1D isa FPLX 000019 ADRA +HGNC 281 ADRA2A isa FPLX 000019 ADRA +HGNC 282 ADRA2B isa FPLX 000019 ADRA +HGNC 283 ADRA2C isa FPLX 000019 ADRA +HGNC 281 ADRA2A isa FPLX 000020 ADRA2 +HGNC 282 ADRA2B isa FPLX 000020 ADRA2 +HGNC 283 ADRA2C isa FPLX 000020 ADRA2 +HGNC 285 ADRB1 isa FPLX 000021 ADRB +HGNC 286 ADRB2 isa FPLX 000021 ADRB +HGNC 288 ADRB3 isa FPLX 000021 ADRB +HGNC 289 GRK2 isa FPLX 000022 ADRBK +HGNC 290 GRK3 isa FPLX 000022 ADRBK +HGNC 402 ALDH1A1 isa FPLX 000024 ALDH +HGNC 15472 ALDH1A2 isa FPLX 000024 ALDH +HGNC 409 ALDH1A3 isa FPLX 000024 ALDH +HGNC 404 ALDH2 isa FPLX 000024 ALDH +HGNC 405 ALDH3A1 isa FPLX 000024 ALDH +HGNC 403 ALDH3A2 isa FPLX 000024 ALDH +HGNC 410 ALDH3B1 isa FPLX 000024 ALDH +HGNC 408 ALDH5A1 isa FPLX 000024 ALDH +HGNC 877 ALDH7A1 isa FPLX 000024 ALDH +HGNC 412 ALDH9A1 isa FPLX 000024 ALDH +HGNC 414 ALDOA isa FPLX 000025 ALDO +HGNC 417 ALDOB isa FPLX 000025 ALDO +HGNC 418 ALDOC isa FPLX 000025 ALDO +HGNC 600 APOA1 isa FPLX 000051 APOA +HGNC 601 APOA2 isa FPLX 000051 APOA +HGNC 602 APOA4 isa FPLX 000051 APOA +HGNC 17288 APOA5 isa FPLX 000051 APOA +FPLX 000051 APOA isa FPLX 000052 Apolipoprotein +HGNC 613 APOE isa FPLX 000052 Apolipoprotein +HGNC 711 ARRB1 isa FPLX 000055 ARRB +HGNC 712 ARRB2 isa FPLX 000055 ARRB +HGNC 16489 ATG4A isa FPLX 000056 ATG4 +HGNC 20790 ATG4B isa FPLX 000056 ATG4 +HGNC 16040 ATG4C isa FPLX 000056 ATG4 +HGNC 20789 ATG4D isa FPLX 000056 ATG4 +HGNC 903 AXIN1 isa FPLX 000062 AXIN +HGNC 904 AXIN2 isa FPLX 000062 AXIN +HGNC 590 BIRC2 isa FPLX 000066 BIRC +HGNC 591 BIRC3 isa FPLX 000066 BIRC +HGNC 593 BIRC5 isa FPLX 000066 BIRC +HGNC 13516 BIRC6 isa FPLX 000066 BIRC +HGNC 13702 BIRC7 isa FPLX 000066 BIRC +HGNC 14878 BIRC8 isa FPLX 000066 BIRC +HGNC 7634 NAIP isa FPLX 000066 BIRC +HGNC 592 XIAP isa FPLX 000066 BIRC +HGNC 4214 GDF1 isa FPLX 000067 BMP +HGNC 4217 GDF2 isa FPLX 000067 BMP +HGNC 4218 GDF3 isa FPLX 000067 BMP +HGNC 4220 GDF5 isa FPLX 000067 BMP +HGNC 4221 GDF6 isa FPLX 000067 BMP +HGNC 4222 GDF7 isa FPLX 000067 BMP +FPLX 000069 BMP_receptor_type_I isa FPLX 000068 BMP_receptor +FPLX 000070 BMP_receptor_type_II isa FPLX 000068 BMP_receptor +HGNC 171 ACVR1 isa FPLX 000069 BMP_receptor_type_I +HGNC 1076 BMPR1A isa FPLX 000069 BMP_receptor_type_I +HGNC 1077 BMPR1B isa FPLX 000069 BMP_receptor_type_I +HGNC 173 ACVR2A isa FPLX 000070 BMP_receptor_type_II +HGNC 174 ACVR2B isa FPLX 000070 BMP_receptor_type_II +HGNC 1078 BMPR2 isa FPLX 000070 BMP_receptor_type_II +HGNC 1442 CALM1 isa FPLX 000075 CALM +HGNC 1445 CALM2 isa FPLX 000075 CALM +HGNC 1449 CALM3 isa FPLX 000075 CALM +HGNC 1459 CAMK1 isa FPLX 000076 CAMK +HGNC 19341 CAMK1D isa FPLX 000076 CAMK +HGNC 14585 CAMK1G isa FPLX 000076 CAMK +HGNC 1460 CAMK2A isa FPLX 000078 CAMK2_family +HGNC 1461 CAMK2B isa FPLX 000078 CAMK2_family +HGNC 1462 CAMK2D isa FPLX 000078 CAMK2_family +HGNC 1463 CAMK2G isa FPLX 000078 CAMK2_family +HGNC 1464 CAMK4 isa FPLX 000076 CAMK +FPLX 000078 CAMK2_family isa FPLX 000076 CAMK +HGNC 1476 CAPN1 isa FPLX 000079 CAPN +HGNC 1477 CAPN10 isa FPLX 000079 CAPN +HGNC 1478 CAPN11 isa FPLX 000079 CAPN +HGNC 13249 CAPN12 isa FPLX 000079 CAPN +HGNC 16663 CAPN13 isa FPLX 000079 CAPN +HGNC 16664 CAPN14 isa FPLX 000079 CAPN +HGNC 1479 CAPN2 isa FPLX 000079 CAPN +HGNC 1480 CAPN3 isa FPLX 000079 CAPN +HGNC 1482 CAPN5 isa FPLX 000079 CAPN +HGNC 1483 CAPN6 isa FPLX 000079 CAPN +HGNC 1484 CAPN7 isa FPLX 000079 CAPN +HGNC 1486 CAPN9 isa FPLX 000079 CAPN +HGNC 11182 CAPN15 isa FPLX 000079 CAPN +HGNC 1485 CAPN8 isa FPLX 000079 CAPN +HGNC 1863 CES1 isa FPLX 000080 Carboxylesterase +HGNC 1864 CES2 isa FPLX 000080 Carboxylesterase +HGNC 1865 CES3 isa FPLX 000080 Carboxylesterase +HGNC 26741 CES4A isa FPLX 000080 Carboxylesterase +HGNC 26459 CES5A isa FPLX 000080 Carboxylesterase +HGNC 1527 CAV1 isa FPLX 000083 CAV +HGNC 1528 CAV2 isa FPLX 000083 CAV +HGNC 1529 CAV3 isa FPLX 000083 CAV +HGNC 3619 FCGR3A isa FPLX 000086 CD16 +HGNC 3620 FCGR3B isa FPLX 000086 CD16 +HGNC 3616 FCGR2A isa FPLX 000088 CD32 +HGNC 3618 FCGR2B isa FPLX 000088 CD32 +HGNC 15626 FCGR2C isa FPLX 000088 CD32 +HGNC 3613 FCGR1A isa FPLX 000089 CD64 +HGNC 3614 FCGR1B isa FPLX 000089 CD64 +HGNC 1725 CDC25A isa FPLX 000091 CDC25 +HGNC 1726 CDC25B isa FPLX 000091 CDC25 +HGNC 1727 CDC25C isa FPLX 000091 CDC25 +HGNC 1748 CDH1 isa FPLX 000074 Cadherin +HGNC 1749 CDH10 isa FPLX 000074 Cadherin +HGNC 1750 CDH11 isa FPLX 000074 Cadherin +HGNC 1751 CDH12 isa FPLX 000074 Cadherin +HGNC 1753 CDH13 isa FPLX 000074 Cadherin +HGNC 1754 CDH15 isa FPLX 000074 Cadherin +HGNC 1755 CDH16 isa FPLX 000074 Cadherin +HGNC 1756 CDH17 isa FPLX 000074 Cadherin +HGNC 1757 CDH18 isa FPLX 000074 Cadherin +HGNC 1758 CDH19 isa FPLX 000074 Cadherin +HGNC 1759 CDH2 isa FPLX 000074 Cadherin +HGNC 1760 CDH20 isa FPLX 000074 Cadherin +HGNC 13251 CDH22 isa FPLX 000074 Cadherin +HGNC 14265 CDH24 isa FPLX 000074 Cadherin +HGNC 1762 CDH3 isa FPLX 000074 Cadherin +HGNC 1763 CDH4 isa FPLX 000074 Cadherin +HGNC 1764 CDH5 isa FPLX 000074 Cadherin +HGNC 1765 CDH6 isa FPLX 000074 Cadherin +HGNC 1766 CDH7 isa FPLX 000074 Cadherin +HGNC 1767 CDH8 isa FPLX 000074 Cadherin +HGNC 1768 CDH9 isa FPLX 000074 Cadherin +HGNC 1833 CEBPA isa FPLX 000097 CEBP +HGNC 1834 CEBPB isa FPLX 000097 CEBP +HGNC 1835 CEBPD isa FPLX 000097 CEBP +HGNC 1837 CEBPG isa FPLX 000097 CEBP +HGNC 1836 CEBPE isa FPLX 000097 CEBP +HGNC 1565 ACKR2 isa FPLX 000100 Chemokine_receptor +HGNC 1602 CCR1 isa FPLX 000100 Chemokine_receptor +HGNC 4474 CCR10 isa FPLX 000100 Chemokine_receptor +HGNC 1603 CCR2 isa FPLX 000100 Chemokine_receptor +HGNC 1604 CCR3 isa FPLX 000100 Chemokine_receptor +HGNC 1605 CCR4 isa FPLX 000100 Chemokine_receptor +HGNC 1606 CCR5 isa FPLX 000100 Chemokine_receptor +HGNC 1607 CCR6 isa FPLX 000100 Chemokine_receptor +HGNC 1608 CCR7 isa FPLX 000100 Chemokine_receptor +HGNC 1609 CCR8 isa FPLX 000100 Chemokine_receptor +HGNC 1610 CCR9 isa FPLX 000100 Chemokine_receptor +HGNC 1611 ACKR4 isa FPLX 000100 Chemokine_receptor +HGNC 1612 CCRL2 isa FPLX 000100 Chemokine_receptor +HGNC 2558 CX3CR1 isa FPLX 000100 Chemokine_receptor +HGNC 6026 CXCR1 isa FPLX 000100 Chemokine_receptor +HGNC 6027 CXCR2 isa FPLX 000100 Chemokine_receptor +HGNC 4540 CXCR3 isa FPLX 000100 Chemokine_receptor +HGNC 2561 CXCR4 isa FPLX 000100 Chemokine_receptor +HGNC 1060 CXCR5 isa FPLX 000100 Chemokine_receptor +HGNC 16647 CXCR6 isa FPLX 000100 Chemokine_receptor +HGNC 23692 ACKR3 isa FPLX 000100 Chemokine_receptor +HGNC 1625 XCR1 isa FPLX 000100 Chemokine_receptor +HGNC 108 ACHE isa FPLX 000101 Cholinesterase +HGNC 983 BCHE isa FPLX 000101 Cholinesterase +HGNC 1950 CHRM1 isa FPLX 000102 CHRM +HGNC 1951 CHRM2 isa FPLX 000102 CHRM +HGNC 1952 CHRM3 isa FPLX 000102 CHRM +HGNC 1953 CHRM4 isa FPLX 000102 CHRM +HGNC 1954 CHRM5 isa FPLX 000102 CHRM +HGNC 2197 COL1A1 isa FPLX 000109 COL1 +HGNC 2198 COL1A2 isa FPLX 000109 COL1 +HGNC 2202 COL4A1 isa FPLX 000110 COL4 +HGNC 2203 COL4A2 isa FPLX 000110 COL4 +HGNC 2204 COL4A3 isa FPLX 000110 COL4 +HGNC 2206 COL4A4 isa FPLX 000110 COL4 +HGNC 2207 COL4A5 isa FPLX 000110 COL4 +HGNC 2208 COL4A6 isa FPLX 000110 COL4 +HGNC 2209 COL5A1 isa FPLX 000111 COL5 +HGNC 2210 COL5A2 isa FPLX 000111 COL5 +HGNC 14864 COL5A3 isa FPLX 000111 COL5 +HGNC 2265 COX4I1 isa FPLX 000114 COX4 +HGNC 16232 COX4I2 isa FPLX 000114 COX4 +HGNC 2277 COX6A1 isa FPLX 000115 COX6A +HGNC 2279 COX6A2 isa FPLX 000115 COX6A +HGNC 2280 COX6B1 isa FPLX 000116 COX6B +HGNC 24380 COX6B2 isa FPLX 000116 COX6B +HGNC 2287 COX7A1 isa FPLX 000117 COX7A +HGNC 2288 COX7A2 isa FPLX 000117 COX7A +HGNC 2291 COX7B isa FPLX 000118 COX7B +HGNC 24381 COX7B2 isa FPLX 000118 COX7B +HGNC 2294 COX8A isa FPLX 000119 COX8 +HGNC 24382 COX8C isa FPLX 000119 COX8 +HGNC 2267 COX5A partof FPLX 000113 COX +HGNC 2269 COX5B partof FPLX 000113 COX +FPLX 000114 COX4 partof FPLX 000113 COX +FPLX 000115 COX6A partof FPLX 000113 COX +FPLX 000116 COX6B partof FPLX 000113 COX +FPLX 000117 COX7A partof FPLX 000113 COX +FPLX 000118 COX7B partof FPLX 000113 COX +FPLX 000119 COX8 partof FPLX 000113 COX +HGNC 2260 COX10 partof FPLX 000113 COX +HGNC 2261 COX11 partof FPLX 000113 COX +HGNC 2263 COX15 partof FPLX 000113 COX +HGNC 2264 COX17 partof FPLX 000113 COX +HGNC 304 CRISP1 isa FPLX 000121 CRISP +HGNC 12024 CRISP2 isa FPLX 000121 CRISP +HGNC 16904 CRISP3 isa FPLX 000121 CRISP +HGNC 2509 CTNNA1 isa FPLX 000126 CTNNA +HGNC 2510 CTNNA2 isa FPLX 000126 CTNNA +HGNC 2511 CTNNA3 isa FPLX 000126 CTNNA +HGNC 2551 CUL1 isa FPLX 000127 CUL +HGNC 2552 CUL2 isa FPLX 000127 CUL +HGNC 2553 CUL3 isa FPLX 000127 CUL +HGNC 2554 CUL4A isa FPLX 000127 CUL +HGNC 2555 CUL4B isa FPLX 000127 CUL +HGNC 2556 CUL5 isa FPLX 000127 CUL +HGNC 21024 CUL7 isa FPLX 000127 CUL +FPLX 000128 CXCL_ELR_negative isa FPLX 000099 Chemokine +FPLX 000129 CXCL_ELR_positive isa FPLX 000099 Chemokine +HGNC 10637 CXCL10 isa FPLX 000128 CXCL_ELR_negative +HGNC 10638 CXCL11 isa FPLX 000128 CXCL_ELR_negative +HGNC 10672 CXCL12 isa FPLX 000128 CXCL_ELR_negative +HGNC 10639 CXCL13 isa FPLX 000128 CXCL_ELR_negative +HGNC 10640 CXCL14 isa FPLX 000128 CXCL_ELR_negative +HGNC 7098 CXCL9 isa FPLX 000128 CXCL_ELR_negative +HGNC 8861 PF4 isa FPLX 000128 CXCL_ELR_negative +HGNC 4602 CXCL1 isa FPLX 000129 CXCL_ELR_positive +HGNC 4603 CXCL2 isa FPLX 000129 CXCL_ELR_positive +HGNC 4604 CXCL3 isa FPLX 000129 CXCL_ELR_positive +HGNC 10642 CXCL5 isa FPLX 000129 CXCL_ELR_positive +HGNC 10643 CXCL6 isa FPLX 000129 CXCL_ELR_positive +HGNC 6025 CXCL8 isa FPLX 000129 CXCL_ELR_positive +HGNC 9240 PPBP isa FPLX 000129 CXCL_ELR_positive +HGNC 10664 CWC27 isa FPLX 000134 Cyclophilin +HGNC 9253 PPIA isa FPLX 000134 Cyclophilin +HGNC 9255 PPIB isa FPLX 000134 Cyclophilin +HGNC 9256 PPIC isa FPLX 000134 Cyclophilin +HGNC 9257 PPID isa FPLX 000134 Cyclophilin +HGNC 9258 PPIE isa FPLX 000134 Cyclophilin +HGNC 9259 PPIF isa FPLX 000134 Cyclophilin +HGNC 14651 PPIH isa FPLX 000134 Cyclophilin +HGNC 9260 PPIL1 isa FPLX 000134 Cyclophilin +HGNC 9261 PPIL2 isa FPLX 000134 Cyclophilin +HGNC 9262 PPIL3 isa FPLX 000134 Cyclophilin +HGNC 15702 PPIL4 isa FPLX 000134 Cyclophilin +HGNC 21557 PPIL6 isa FPLX 000134 Cyclophilin +HGNC 28954 PPWD1 isa FPLX 000134 Cyclophilin +HGNC 24369 PPIAL4A isa FPLX 000134 Cyclophilin +HGNC 33995 PPIAL4C isa FPLX 000134 Cyclophilin +HGNC 33996 PPIAL4G isa FPLX 000134 Cyclophilin +HGNC 2730 DDR1 isa FPLX 000136 DDR +HGNC 2731 DDR2 isa FPLX 000136 DDR +HGNC 3048 DSG1 isa FPLX 000138 Desmoglein +HGNC 3049 DSG2 isa FPLX 000138 Desmoglein +HGNC 3050 DSG3 isa FPLX 000138 Desmoglein +HGNC 21307 DSG4 isa FPLX 000138 Desmoglein +HGNC 2849 DGKA isa FPLX 000140 DGK +HGNC 2850 DGKB isa FPLX 000140 DGK +HGNC 2851 DGKD isa FPLX 000140 DGK +HGNC 2853 DGKG isa FPLX 000140 DGK +HGNC 2854 DGKH isa FPLX 000140 DGK +HGNC 2856 DGKQ isa FPLX 000140 DGK +HGNC 2857 DGKZ isa FPLX 000140 DGK +HGNC 2852 DGKE isa FPLX 000140 DGK +HGNC 2855 DGKI isa FPLX 000140 DGK +HGNC 32395 DGKK isa FPLX 000140 DGK +HGNC 2972 DNM1 isa FPLX 000142 DNM +HGNC 2974 DNM2 isa FPLX 000142 DNM +HGNC 29125 DNM3 isa FPLX 000142 DNM +HGNC 3020 DRD1 isa FPLX 000143 DRD +HGNC 3023 DRD2 isa FPLX 000143 DRD +HGNC 3024 DRD3 isa FPLX 000143 DRD +HGNC 3025 DRD4 isa FPLX 000143 DRD +HGNC 3026 DRD5 isa FPLX 000143 DRD +HGNC 3084 DVL1 isa FPLX 000145 DVL +HGNC 3086 DVL2 isa FPLX 000145 DVL +HGNC 3087 DVL3 isa FPLX 000145 DVL +HGNC 3113 E2F1 isa FPLX 000147 E2F +HGNC 3114 E2F2 isa FPLX 000147 E2F +HGNC 3115 E2F3 isa FPLX 000147 E2F +HGNC 3118 E2F4 isa FPLX 000147 E2F +HGNC 3119 E2F5 isa FPLX 000147 E2F +HGNC 3120 E2F6 isa FPLX 000147 E2F +HGNC 23820 E2F7 isa FPLX 000147 E2F +HGNC 24727 E2F8 isa FPLX 000147 E2F +HGNC 3176 EDN1 isa FPLX 000149 EDN +HGNC 3177 EDN2 isa FPLX 000149 EDN +HGNC 3178 EDN3 isa FPLX 000149 EDN +HGNC 651 AREG isa FPLX 000150 EGFR_ligand +HGNC 3229 EGF isa FPLX 000150 EGFR_ligand +HGNC 11765 TGFA isa FPLX 000150 EGFR_ligand +HGNC 3059 HBEGF isa FPLX 000150 EGFR_ligand +HGNC 1121 BTC isa FPLX 000150 EGFR_ligand +HGNC 3443 EREG isa FPLX 000150 EGFR_ligand +HGNC 17470 EPGN isa FPLX 000150 EGFR_ligand +HGNC 3238 EGR1 isa FPLX 000151 EGR +HGNC 3239 EGR2 isa FPLX 000151 EGR +HGNC 3240 EGR3 isa FPLX 000151 EGR +HGNC 3241 EGR4 isa FPLX 000151 EGR +HGNC 3282 EIF4A1 isa FPLX 000153 EIF4A +HGNC 3284 EIF4A2 isa FPLX 000153 EIF4A +HGNC 18683 EIF4A3 isa FPLX 000153 EIF4A +HGNC 913 AZU1 isa FPLX 000156 ELA +HGNC 3308 CELA1 isa FPLX 000156 ELA +HGNC 24609 CELA2A isa FPLX 000156 ELA +HGNC 29995 CELA2B isa FPLX 000156 ELA +HGNC 15944 CELA3A isa FPLX 000156 ELA +HGNC 15945 CELA3B isa FPLX 000156 ELA +HGNC 2523 CTRC isa FPLX 000156 ELA +HGNC 3309 ELANE isa FPLX 000156 ELA +HGNC 9495 PRTN3 isa FPLX 000156 ELA +HGNC 3350 ENO1 isa FPLX 000157 ENO +HGNC 3353 ENO2 isa FPLX 000157 ENO +HGNC 3354 ENO3 isa FPLX 000157 ENO +HGNC 31670 ENO4 isa FPLX 000157 ENO +HGNC 3385 EPHA1 isa FPLX 000158 Ephrin_receptor +HGNC 3386 EPHA2 isa FPLX 000158 Ephrin_receptor +HGNC 3387 EPHA3 isa FPLX 000158 Ephrin_receptor +HGNC 3388 EPHA4 isa FPLX 000158 Ephrin_receptor +HGNC 3389 EPHA5 isa FPLX 000158 Ephrin_receptor +HGNC 19296 EPHA6 isa FPLX 000158 Ephrin_receptor +HGNC 3390 EPHA7 isa FPLX 000158 Ephrin_receptor +HGNC 3391 EPHA8 isa FPLX 000158 Ephrin_receptor +HGNC 3392 EPHB1 isa FPLX 000158 Ephrin_receptor +HGNC 3393 EPHB2 isa FPLX 000158 Ephrin_receptor +HGNC 3394 EPHB3 isa FPLX 000158 Ephrin_receptor +HGNC 3395 EPHB4 isa FPLX 000158 Ephrin_receptor +HGNC 3396 EPHB6 isa FPLX 000158 Ephrin_receptor +HGNC 19987 EPHA10 isa FPLX 000158 Ephrin_receptor +HGNC 21604 EPN1 isa FPLX 000159 EPN +HGNC 18639 EPN2 isa FPLX 000159 EPN +HGNC 18235 EPN3 isa FPLX 000159 EPN +HGNC 23186 CLINT1 isa FPLX 000159 EPN +HGNC 3467 ESR1 isa FPLX 000162 ESR +HGNC 3468 ESR2 isa FPLX 000162 ESR +HGNC 3757 FLOT1 isa FPLX 000170 FLOT +HGNC 3758 FLOT2 isa FPLX 000170 FLOT +HGNC 3760 FLRT1 isa FPLX 000171 FLRT +HGNC 3761 FLRT2 isa FPLX 000171 FLRT +HGNC 3762 FLRT3 isa FPLX 000171 FLRT +HGNC 4038 FZD1 isa FPLX 000177 FZD +HGNC 4039 FZD10 isa FPLX 000177 FZD +HGNC 4040 FZD2 isa FPLX 000177 FZD +HGNC 4041 FZD3 isa FPLX 000177 FZD +HGNC 4042 FZD4 isa FPLX 000177 FZD +HGNC 4043 FZD5 isa FPLX 000177 FZD +HGNC 4044 FZD6 isa FPLX 000177 FZD +HGNC 4045 FZD7 isa FPLX 000177 FZD +HGNC 4046 FZD8 isa FPLX 000177 FZD +HGNC 4047 FZD9 isa FPLX 000177 FZD +HGNC 4075 GABRA1 isa FPLX 000179 GABR +HGNC 4076 GABRA2 isa FPLX 000179 GABR +HGNC 4077 GABRA3 isa FPLX 000179 GABR +HGNC 4078 GABRA4 isa FPLX 000179 GABR +HGNC 4079 GABRA5 isa FPLX 000179 GABR +HGNC 4080 GABRA6 isa FPLX 000179 GABR +HGNC 4081 GABRB1 isa FPLX 000179 GABR +HGNC 4082 GABRB2 isa FPLX 000179 GABR +HGNC 4083 GABRB3 isa FPLX 000179 GABR +HGNC 4084 GABRD isa FPLX 000179 GABR +HGNC 4085 GABRE isa FPLX 000179 GABR +HGNC 4086 GABRG1 isa FPLX 000179 GABR +HGNC 4087 GABRG2 isa FPLX 000179 GABR +HGNC 4088 GABRG3 isa FPLX 000179 GABR +HGNC 4089 GABRP isa FPLX 000179 GABR +HGNC 14454 GABRQ isa FPLX 000179 GABR +HGNC 4090 GABRR1 isa FPLX 000179 GABR +HGNC 4091 GABRR2 isa FPLX 000179 GABR +HGNC 17969 GABRR3 isa FPLX 000179 GABR +HGNC 905 AXL isa FPLX 000183 GAS6_receptor +HGNC 7027 MERTK isa FPLX 000183 GAS6_receptor +HGNC 12446 TYRO3 isa FPLX 000183 GAS6_receptor +HGNC 4170 GATA1 isa FPLX 000184 GATA +HGNC 4171 GATA2 isa FPLX 000184 GATA +HGNC 4172 GATA3 isa FPLX 000184 GATA +HGNC 4173 GATA4 isa FPLX 000184 GATA +HGNC 15802 GATA5 isa FPLX 000184 GATA +HGNC 4174 GATA6 isa FPLX 000184 GATA +HGNC 4396 GNB1 isa FPLX 000210 G_beta +HGNC 4398 GNB2 isa FPLX 000210 G_beta +HGNC 4400 GNB3 isa FPLX 000210 G_beta +HGNC 20731 GNB4 isa FPLX 000210 G_beta +HGNC 4401 GNB5 isa FPLX 000210 G_beta +HGNC 4402 GNG10 isa FPLX 000211 G_gamma +HGNC 4403 GNG11 isa FPLX 000211 G_gamma +HGNC 19663 GNG12 isa FPLX 000211 G_gamma +HGNC 14131 GNG13 isa FPLX 000211 G_gamma +HGNC 4404 GNG2 isa FPLX 000211 G_gamma +HGNC 4405 GNG3 isa FPLX 000211 G_gamma +HGNC 4407 GNG4 isa FPLX 000211 G_gamma +HGNC 4408 GNG5 isa FPLX 000211 G_gamma +HGNC 4410 GNG7 isa FPLX 000211 G_gamma +HGNC 19664 GNG8 isa FPLX 000211 G_gamma +HGNC 4411 GNGT1 isa FPLX 000211 G_gamma +HGNC 4412 GNGT2 isa FPLX 000211 G_gamma +HGNC 4553 GPX1 isa FPLX 000190 GPX +HGNC 4554 GPX2 isa FPLX 000190 GPX +HGNC 4555 GPX3 isa FPLX 000190 GPX +HGNC 4556 GPX4 isa FPLX 000190 GPX +HGNC 4557 GPX5 isa FPLX 000190 GPX +HGNC 4558 GPX6 isa FPLX 000190 GPX +HGNC 4559 GPX7 isa FPLX 000190 GPX +HGNC 33100 GPX8 isa FPLX 000190 GPX +HGNC 4571 GRIA1 isa FPLX 000191 GRIA +HGNC 4572 GRIA2 isa FPLX 000191 GRIA +HGNC 4573 GRIA3 isa FPLX 000191 GRIA +HGNC 4574 GRIA4 isa FPLX 000191 GRIA +FPLX 000022 ADRBK isa FPLX 000192 GRK +HGNC 10013 GRK1 isa FPLX 000192 GRK +HGNC 4543 GRK4 isa FPLX 000192 GRK +HGNC 4544 GRK5 isa FPLX 000192 GRK +HGNC 4545 GRK6 isa FPLX 000192 GRK +HGNC 17031 GRK7 isa FPLX 000192 GRK +HGNC 4593 GRM1 isa FPLX 000193 GRM +HGNC 4594 GRM2 isa FPLX 000193 GRM +HGNC 4595 GRM3 isa FPLX 000193 GRM +HGNC 4596 GRM4 isa FPLX 000193 GRM +HGNC 4597 GRM5 isa FPLX 000193 GRM +HGNC 4598 GRM6 isa FPLX 000193 GRM +HGNC 4599 GRM7 isa FPLX 000193 GRM +HGNC 4600 GRM8 isa FPLX 000193 GRM +HGNC 4626 GSTA1 isa FPLX 000195 GST +HGNC 4627 GSTA2 isa FPLX 000195 GST +HGNC 4628 GSTA3 isa FPLX 000195 GST +HGNC 4629 GSTA4 isa FPLX 000195 GST +HGNC 19662 GSTA5 isa FPLX 000195 GST +HGNC 16906 GSTK1 isa FPLX 000195 GST +HGNC 4632 GSTM1 isa FPLX 000195 GST +HGNC 4634 GSTM2 isa FPLX 000195 GST +HGNC 4635 GSTM3 isa FPLX 000195 GST +HGNC 4636 GSTM4 isa FPLX 000195 GST +HGNC 4637 GSTM5 isa FPLX 000195 GST +HGNC 13312 GSTO1 isa FPLX 000195 GST +HGNC 23064 GSTO2 isa FPLX 000195 GST +HGNC 4638 GSTP1 isa FPLX 000195 GST +HGNC 4641 GSTT1 isa FPLX 000195 GST +HGNC 4642 GSTT2 isa FPLX 000195 GST +HGNC 4643 GSTZ1 isa FPLX 000195 GST +HGNC 33437 GSTT2B isa FPLX 000195 GST +HGNC 4688 GUCY2C isa FPLX 000205 GUCY +HGNC 4689 GUCY2D isa FPLX 000205 GUCY +HGNC 4691 GUCY2F isa FPLX 000205 GUCY +HGNC 7943 NPR1 isa FPLX 000205 GUCY +HGNC 7944 NPR2 isa FPLX 000205 GUCY +HGNC 2865 DHH isa FPLX 000226 Hedgehog +HGNC 5956 IHH isa FPLX 000226 Hedgehog +HGNC 10848 SHH isa FPLX 000226 Hedgehog +HGNC 5192 HES1 isa FPLX 000228 HES +HGNC 16005 HES2 isa FPLX 000228 HES +HGNC 26226 HES3 isa FPLX 000228 HES +HGNC 24149 HES4 isa FPLX 000228 HES +HGNC 19764 HES5 isa FPLX 000228 HES +HGNC 18254 HES6 isa FPLX 000228 HES +HGNC 15977 HES7 isa FPLX 000228 HES +HGNC 4947 HLA-DRA isa FPLX 000239 HLA_DR +HGNC 4948 HLA-DRB1 isa FPLX 000239 HLA_DR +HGNC 4951 HLA-DRB3 isa FPLX 000239 HLA_DR +HGNC 4952 HLA-DRB4 isa FPLX 000239 HLA_DR +HGNC 4953 HLA-DRB5 isa FPLX 000239 HLA_DR +HGNC 5013 HMOX1 isa FPLX 000240 HMOX +HGNC 5014 HMOX2 isa FPLX 000240 HMOX +HGNC 19022 HSPA12A isa FPLX 000244 HSPA +HGNC 16193 HSPA12B isa FPLX 000244 HSPA +HGNC 11375 HSPA13 isa FPLX 000244 HSPA +HGNC 29526 HSPA14 isa FPLX 000244 HSPA +HGNC 5232 HSPA1A isa FPLX 000244 HSPA +HGNC 5233 HSPA1B isa FPLX 000244 HSPA +HGNC 5234 HSPA1L isa FPLX 000244 HSPA +HGNC 5235 HSPA2 isa FPLX 000244 HSPA +HGNC 5237 HSPA4 isa FPLX 000244 HSPA +HGNC 17041 HSPA4L isa FPLX 000244 HSPA +HGNC 5238 HSPA5 isa FPLX 000244 HSPA +HGNC 5239 HSPA6 isa FPLX 000244 HSPA +HGNC 5241 HSPA8 isa FPLX 000244 HSPA +HGNC 5244 HSPA9 isa FPLX 000244 HSPA +HGNC 16969 HSPH1 isa FPLX 000244 HSPA +HGNC 16931 HYOU1 isa FPLX 000244 HSPA +HGNC 5246 HSPB1 isa FPLX 000245 HSPB +HGNC 5247 HSPB2 isa FPLX 000245 HSPB +HGNC 30171 HSPB8 isa FPLX 000245 HSPB +HGNC 5469 IGFBP1 isa FPLX 000248 IGFBP +HGNC 5471 IGFBP2 isa FPLX 000248 IGFBP +HGNC 5472 IGFBP3 isa FPLX 000248 IGFBP +HGNC 5473 IGFBP4 isa FPLX 000248 IGFBP +HGNC 5474 IGFBP5 isa FPLX 000248 IGFBP +HGNC 5475 IGFBP6 isa FPLX 000248 IGFBP +HGNC 5476 IGFBP7 isa FPLX 000248 IGFBP +HGNC 1974 CHUK isa FPLX 000251 IKK_family +HGNC 5960 IKBKB isa FPLX 000251 IKK_family +HGNC 5961 IKBKG isa FPLX 000251 IKK_family +HGNC 14552 IKBKE isa FPLX 000251 IKK_family +HGNC 11584 TBK1 isa FPLX 000251 IKK_family +HGNC 5465 IGF1R isa FPLX 000260 INSR +HGNC 6081 INS isa FPLX 000259 INS +HGNC 6091 INSR isa FPLX 000260 INSR +HGNC 6093 INSRR isa FPLX 000260 INSR +HGNC 6125 IRS1 isa FPLX 000264 IRS +HGNC 6126 IRS2 isa FPLX 000264 IRS +HGNC 6128 IRS4 isa FPLX 000264 IRS +HGNC 14358 IRX1 isa FPLX 000265 IRX +HGNC 14359 IRX2 isa FPLX 000265 IRX +HGNC 14360 IRX3 isa FPLX 000265 IRX +HGNC 6129 IRX4 isa FPLX 000265 IRX +HGNC 14361 IRX5 isa FPLX 000265 IRX +HGNC 14675 IRX6 isa FPLX 000265 IRX +HGNC 23729 MKX isa FPLX 000265 IRX +HGNC 6357 KLK1 isa FPLX 000271 KLK +HGNC 6358 KLK10 isa FPLX 000271 KLK +HGNC 6359 KLK11 isa FPLX 000271 KLK +HGNC 6360 KLK12 isa FPLX 000271 KLK +HGNC 6361 KLK13 isa FPLX 000271 KLK +HGNC 6362 KLK14 isa FPLX 000271 KLK +HGNC 20453 KLK15 isa FPLX 000271 KLK +HGNC 6363 KLK2 isa FPLX 000271 KLK +HGNC 6364 KLK3 isa FPLX 000271 KLK +HGNC 6365 KLK4 isa FPLX 000271 KLK +HGNC 6366 KLK5 isa FPLX 000271 KLK +HGNC 6367 KLK6 isa FPLX 000271 KLK +HGNC 6368 KLK7 isa FPLX 000271 KLK +HGNC 6369 KLK8 isa FPLX 000271 KLK +HGNC 6370 KLK9 isa FPLX 000271 KLK +HGNC 6371 KLKB1 isa FPLX 000271 KLK +HGNC 6776 MAF isa FPLX 000279 MAF +HGNC 23145 MAFA isa FPLX 000279 MAF +HGNC 6408 MAFB isa FPLX 000279 MAF +HGNC 6780 MAFF isa FPLX 000279 MAF +HGNC 6781 MAFG isa FPLX 000279 MAF +HGNC 6782 MAFK isa FPLX 000279 MAF +HGNC 6881 MAPK8 isa FPLX 000267 JNK +HGNC 6886 MAPK9 isa FPLX 000267 JNK +HGNC 6872 MAPK10 isa FPLX 000267 JNK +FPLX 000267 JNK isa FPLX 000283 MAPK +HGNC 6993 MEF2A isa FPLX 000285 MEF2 +HGNC 6996 MEF2C isa FPLX 000285 MEF2 +HGNC 6997 MEF2D isa FPLX 000285 MEF2 +HGNC 6995 MEF2B isa FPLX 000285 MEF2 +HGNC 7567 MYH1 isa FPLX 000295 MYH +HGNC 7568 MYH10 isa FPLX 000295 MYH +HGNC 7569 MYH11 isa FPLX 000295 MYH +HGNC 7571 MYH13 isa FPLX 000295 MYH +HGNC 23212 MYH14 isa FPLX 000295 MYH +HGNC 31073 MYH15 isa FPLX 000295 MYH +HGNC 7572 MYH2 isa FPLX 000295 MYH +HGNC 7573 MYH3 isa FPLX 000295 MYH +HGNC 7574 MYH4 isa FPLX 000295 MYH +HGNC 7576 MYH6 isa FPLX 000295 MYH +HGNC 7577 MYH7 isa FPLX 000295 MYH +HGNC 15906 MYH7B isa FPLX 000295 MYH +HGNC 7578 MYH8 isa FPLX 000295 MYH +HGNC 7579 MYH9 isa FPLX 000295 MYH +HGNC 7602 MYO5A isa FPLX 000295 MYH +HGNC 7582 MYL1 isa FPLX 000297 MYL_alkali +HGNC 7584 MYL3 isa FPLX 000297 MYL_alkali +HGNC 7585 MYL4 isa FPLX 000297 MYL_alkali +HGNC 7587 MYL6 isa FPLX 000297 MYL_alkali +HGNC 29823 MYL6B isa FPLX 000297 MYL_alkali +HGNC 29825 MYL10 isa FPLX 000298 MYL_regulatory +HGNC 16701 MYL12A isa FPLX 000298 MYL_regulatory +HGNC 29827 MYL12B isa FPLX 000298 MYL_regulatory +HGNC 7583 MYL2 isa FPLX 000298 MYL_regulatory +HGNC 7586 MYL5 isa FPLX 000298 MYL_regulatory +HGNC 21719 MYL7 isa FPLX 000298 MYL_regulatory +HGNC 15754 MYL9 isa FPLX 000298 MYL_regulatory +HGNC 29824 MYLPF isa FPLX 000298 MYL_regulatory +HGNC 7583 MYL2 isa FPLX 000299 MYL_slow +HGNC 7584 MYL3 isa FPLX 000299 MYL_slow +HGNC 29823 MYL6B isa FPLX 000299 MYL_slow +FPLX 000297 MYL_alkali isa FPLX 000296 MYL +FPLX 000298 MYL_regulatory isa FPLX 000296 MYL +FPLX 000299 MYL_slow isa FPLX 000296 MYL +HGNC 17933 KAT8 isa FPLX 000300 MYST +HGNC 17016 KAT7 isa FPLX 000300 MYST +HGNC 13013 KAT6A isa FPLX 000300 MYST +HGNC 17582 KAT6B isa FPLX 000300 MYST +HGNC 5275 KAT5 isa FPLX 000300 MYST +HGNC 7668 NCOA1 isa FPLX 000305 NCOA +HGNC 7669 NCOA2 isa FPLX 000305 NCOA +HGNC 7670 NCOA3 isa FPLX 000305 NCOA +HGNC 7672 NCOR1 isa FPLX 000306 NCOR +HGNC 7673 NCOR2 isa FPLX 000306 NCOR +HGNC 7679 NDRG1 isa FPLX 000307 NDRG +HGNC 14460 NDRG2 isa FPLX 000307 NDRG +HGNC 14462 NDRG3 isa FPLX 000307 NDRG +HGNC 14466 NDRG4 isa FPLX 000307 NDRG +HGNC 17045 NKD1 isa FPLX 000315 NKD +HGNC 17046 NKD2 isa FPLX 000315 NKD +HGNC 7872 NOS1 isa FPLX 000316 NOS +HGNC 7873 NOS2 isa FPLX 000316 NOS +HGNC 7876 NOS3 isa FPLX 000316 NOS +HGNC 7881 NOTCH1 isa FPLX 000317 Notch +HGNC 7882 NOTCH2 isa FPLX 000317 Notch +HGNC 7883 NOTCH3 isa FPLX 000317 Notch +HGNC 7884 NOTCH4 isa FPLX 000317 Notch +HGNC 7997 NRG1 isa FPLX 000319 NRG_1_2 +HGNC 7998 NRG2 isa FPLX 000319 NRG_1_2 +HGNC 7999 NRG3 isa FPLX 000320 NRG_3_4 +HGNC 29862 NRG4 isa FPLX 000320 NRG_3_4 +FPLX 000319 NRG_1_2 isa FPLX 000318 NRG +FPLX 000320 NRG_3_4 isa FPLX 000318 NRG +HGNC 8031 NTRK1 isa FPLX 000321 NTRK +HGNC 8032 NTRK2 isa FPLX 000321 NTRK +HGNC 8033 NTRK3 isa FPLX 000321 NTRK +HGNC 8533 P2RX1 isa FPLX 000324 P2RX +HGNC 15459 P2RX2 isa FPLX 000324 P2RX +HGNC 8534 P2RX3 isa FPLX 000324 P2RX +HGNC 8535 P2RX4 isa FPLX 000324 P2RX +HGNC 8536 P2RX5 isa FPLX 000324 P2RX +HGNC 8538 P2RX6 isa FPLX 000324 P2RX +HGNC 8537 P2RX7 isa FPLX 000324 P2RX +HGNC 8539 P2RY1 isa FPLX 000325 P2RY +HGNC 8541 P2RY2 isa FPLX 000325 P2RY +HGNC 8542 P2RY4 isa FPLX 000325 P2RY +HGNC 8543 P2RY6 isa FPLX 000325 P2RY +HGNC 15524 P2RY8 isa FPLX 000325 P2RY +HGNC 19906 P2RY10 isa FPLX 000325 P2RY +HGNC 8540 P2RY11 isa FPLX 000325 P2RY +HGNC 18124 P2RY12 isa FPLX 000325 P2RY +HGNC 4537 P2RY13 isa FPLX 000325 P2RY +HGNC 16442 P2RY14 isa FPLX 000325 P2RY +HGNC 4478 LPAR4 isa FPLX 000325 P2RY +HGNC 15520 LPAR6 isa FPLX 000325 P2RY +HGNC 14652 PARVA isa FPLX 000332 PARV +HGNC 14653 PARVB isa FPLX 000332 PARV +HGNC 14654 PARVG isa FPLX 000332 PARV +HGNC 8632 PBX1 isa FPLX 000334 PBX +HGNC 8633 PBX2 isa FPLX 000334 PBX +HGNC 8634 PBX3 isa FPLX 000334 PBX +HGNC 13403 PBX4 isa FPLX 000334 PBX +HGNC 8774 PDE1A isa FPLX 000336 PDE1 +HGNC 8775 PDE1B isa FPLX 000336 PDE1 +HGNC 8776 PDE1C isa FPLX 000336 PDE1 +HGNC 8777 PDE2A isa FPLX 000335 PDE +HGNC 8778 PDE3A isa FPLX 000337 PDE3 +HGNC 8779 PDE3B isa FPLX 000337 PDE3 +HGNC 8780 PDE4A isa FPLX 000338 PDE4 +HGNC 8781 PDE4B isa FPLX 000338 PDE4 +HGNC 8782 PDE4C isa FPLX 000338 PDE4 +HGNC 8783 PDE4D isa FPLX 000338 PDE4 +HGNC 8785 PDE6A isa FPLX 000339 PDE6 +HGNC 8786 PDE6B isa FPLX 000339 PDE6 +HGNC 8787 PDE6C isa FPLX 000339 PDE6 +HGNC 8791 PDE7A isa FPLX 000340 PDE7 +HGNC 8792 PDE7B isa FPLX 000340 PDE7 +HGNC 8793 PDE8A isa FPLX 000341 PDE8 +HGNC 8794 PDE8B isa FPLX 000341 PDE8 +HGNC 8795 PDE9A isa FPLX 000335 PDE +HGNC 8772 PDE10A isa FPLX 000335 PDE +HGNC 8773 PDE11A isa FPLX 000335 PDE +FPLX 000336 PDE1 isa FPLX 000335 PDE +FPLX 000337 PDE3 isa FPLX 000335 PDE +FPLX 000338 PDE4 isa FPLX 000335 PDE +FPLX 000339 PDE6 isa FPLX 000335 PDE +FPLX 000340 PDE7 isa FPLX 000335 PDE +FPLX 000341 PDE8 isa FPLX 000335 PDE +HGNC 8809 PDK1 isa FPLX 000353 PDK +HGNC 8810 PDK2 isa FPLX 000353 PDK +HGNC 8811 PDK3 isa FPLX 000353 PDK +HGNC 8812 PDK4 isa FPLX 000353 PDK +HGNC 8881 PFN1 isa FPLX 000355 PFN +HGNC 8882 PFN2 isa FPLX 000355 PFN +HGNC 18627 PFN3 isa FPLX 000355 PFN +HGNC 31103 PFN4 isa FPLX 000355 PFN +HGNC 8975 PIK3CA isa FPLX 000359 PI3K_p110 +HGNC 8976 PIK3CB isa FPLX 000359 PI3K_p110 +HGNC 8977 PIK3CD isa FPLX 000359 PI3K_p110 +HGNC 8978 PIK3CG isa FPLX 000359 PI3K_p110 +HGNC 8979 PIK3R1 isa FPLX 000360 PI3K_p85 +HGNC 8980 PIK3R2 isa FPLX 000360 PI3K_p85 +HGNC 8981 PIK3R3 isa FPLX 000361 PIK3R_I +HGNC 8982 PIK3R4 isa FPLX 000361 PIK3R_I +HGNC 30035 PIK3R5 isa FPLX 000361 PIK3R_I +HGNC 27101 PIK3R6 isa FPLX 000361 PIK3R_I +FPLX 000360 PI3K_p85 isa FPLX 000361 PIK3R_I +FPLX 000359 PI3K_p110 partof FPLX 000358 PI3K +FPLX 000361 PIK3R_I partof FPLX 000358 PI3K +HGNC 9017 PKIA isa FPLX 000365 PKI +HGNC 9018 PKIB isa FPLX 000365 PKI +HGNC 9019 PKIG isa FPLX 000365 PKI +HGNC 9030 PLA2G1B isa FPLX 000366 PLA2 +HGNC 9031 PLA2G2A isa FPLX 000367 PLA2G2 +HGNC 9032 PLA2G2C isa FPLX 000367 PLA2G2 +HGNC 9033 PLA2G2D isa FPLX 000367 PLA2G2 +HGNC 13414 PLA2G2E isa FPLX 000367 PLA2G2 +HGNC 30040 PLA2G2F isa FPLX 000367 PLA2G2 +HGNC 17934 PLA2G3 isa FPLX 000366 PLA2 +HGNC 9035 PLA2G4A isa FPLX 000368 PLA2G4 +HGNC 9037 PLA2G4C isa FPLX 000368 PLA2G4 +HGNC 30038 PLA2G4D isa FPLX 000368 PLA2G4 +HGNC 9038 PLA2G5 isa FPLX 000366 PLA2 +HGNC 9039 PLA2G6 isa FPLX 000366 PLA2 +HGNC 9040 PLA2G7 isa FPLX 000366 PLA2 +HGNC 9029 PLA2G10 isa FPLX 000366 PLA2 +HGNC 18554 PLA2G12A isa FPLX 000366 PLA2 +HGNC 18555 PLA2G12B isa FPLX 000366 PLA2 +FPLX 000367 PLA2G2 isa FPLX 000366 PLA2 +FPLX 000368 PLA2G4 isa FPLX 000366 PLA2 +HGNC 15917 PLCB1 isa FPLX 000370 PLCB +HGNC 9055 PLCB2 isa FPLX 000370 PLCB +HGNC 9056 PLCB3 isa FPLX 000370 PLCB +HGNC 9059 PLCB4 isa FPLX 000370 PLCB +HGNC 9060 PLCD1 isa FPLX 000371 PLCD +HGNC 9061 PLCD3 isa FPLX 000371 PLCD +HGNC 9062 PLCD4 isa FPLX 000371 PLCD +HGNC 17175 PLCE1 isa FPLX 000369 PLC +HGNC 9065 PLCG1 isa FPLX 000372 PLCG +HGNC 9066 PLCG2 isa FPLX 000372 PLCG +HGNC 19218 PLCZ1 isa FPLX 000369 PLC +FPLX 000370 PLCB isa FPLX 000369 PLC +FPLX 000371 PLCD isa FPLX 000369 PLC +FPLX 000372 PLCG isa FPLX 000369 PLC +HGNC 9067 PLD1 isa FPLX 000373 PLD +HGNC 9068 PLD2 isa FPLX 000373 PLD +HGNC 17158 PLD3 isa FPLX 000373 PLD +HGNC 23792 PLD4 isa FPLX 000373 PLD +HGNC 26879 PLD5 isa FPLX 000373 PLD +HGNC 30447 PLD6 isa FPLX 000373 PLD +HGNC 9228 PLPP1 isa FPLX 000374 PPAP2 +HGNC 9230 PLPP2 isa FPLX 000374 PPAP2 +HGNC 9229 PLPP3 isa FPLX 000374 PPAP2 +HGNC 9232 PPARA isa FPLX 000375 PPAR +HGNC 9235 PPARD isa FPLX 000375 PPAR +HGNC 9236 PPARG isa FPLX 000375 PPAR +HGNC 9281 PPP1CA isa FPLX 000377 PPP1C +HGNC 9282 PPP1CB isa FPLX 000377 PPP1C +HGNC 9283 PPP1CC isa FPLX 000377 PPP1C +HGNC 9284 PPP1R10 isa FPLX 000378 PPP1R +HGNC 9285 PPP1R11 isa FPLX 000378 PPP1R +HGNC 7618 PPP1R12A isa FPLX 000378 PPP1R +HGNC 7619 PPP1R12B isa FPLX 000378 PPP1R +HGNC 14947 PPP1R12C isa FPLX 000378 PPP1R +HGNC 14950 PPP1R13B isa FPLX 000378 PPP1R +HGNC 14871 PPP1R14A isa FPLX 000378 PPP1R +HGNC 9057 PPP1R14B isa FPLX 000378 PPP1R +HGNC 14952 PPP1R14C isa FPLX 000378 PPP1R +HGNC 14953 PPP1R14D isa FPLX 000378 PPP1R +HGNC 14375 PPP1R15A isa FPLX 000378 PPP1R +HGNC 14951 PPP1R15B isa FPLX 000378 PPP1R +HGNC 14941 PPP1R16A isa FPLX 000378 PPP1R +HGNC 15850 PPP1R16B isa FPLX 000378 PPP1R +HGNC 9286 PPP1R1A isa FPLX 000378 PPP1R +HGNC 9287 PPP1R1B isa FPLX 000378 PPP1R +HGNC 14940 PPP1R1C isa FPLX 000378 PPP1R +HGNC 9288 PPP1R2 isa FPLX 000378 PPP1R +HGNC 9291 PPP1R3A isa FPLX 000378 PPP1R +HGNC 14942 PPP1R3B isa FPLX 000378 PPP1R +HGNC 9293 PPP1R3C isa FPLX 000378 PPP1R +HGNC 9294 PPP1R3D isa FPLX 000378 PPP1R +HGNC 14944 PPP1R3F isa FPLX 000378 PPP1R +HGNC 9295 PPP1R7 isa FPLX 000378 PPP1R +HGNC 9296 PPP1R8 isa FPLX 000378 PPP1R +HGNC 14946 PPP1R9A isa FPLX 000378 PPP1R +HGNC 9298 PPP1R9B isa FPLX 000378 PPP1R +FPLX 000377 PPP1C partof FPLX 000376 PPP1 +FPLX 000378 PPP1R partof FPLX 000376 PPP1 +HGNC 20785 PPM1J isa FPLX 000380 PPP2C +HGNC 9299 PPP2CA isa FPLX 000380 PPP2C +HGNC 9300 PPP2CB isa FPLX 000380 PPP2C +HGNC 9302 PPP2R1A isa FPLX 000381 PPP2R_A +HGNC 9303 PPP2R1B isa FPLX 000381 PPP2R_A +HGNC 9304 PPP2R2A isa FPLX 000382 PPP2R_B +HGNC 9305 PPP2R2B isa FPLX 000382 PPP2R_B +HGNC 9306 PPP2R2C isa FPLX 000382 PPP2R_B +HGNC 23732 PPP2R2D isa FPLX 000382 PPP2R_B +HGNC 9307 PPP2R3A isa FPLX 000382 PPP2R_B +HGNC 13417 PPP2R3B isa FPLX 000382 PPP2R_B +HGNC 9308 PTPA isa FPLX 000382 PPP2R_B +HGNC 9309 PPP2R5A isa FPLX 000382 PPP2R_B +HGNC 9310 PPP2R5B isa FPLX 000382 PPP2R_B +HGNC 9311 PPP2R5C isa FPLX 000382 PPP2R_B +HGNC 9312 PPP2R5D isa FPLX 000382 PPP2R_B +HGNC 9313 PPP2R5E isa FPLX 000382 PPP2R_B +FPLX 000380 PPP2C partof FPLX 000379 PPP2 +FPLX 000381 PPP2R_A partof FPLX 000379 PPP2 +FPLX 000382 PPP2R_B partof FPLX 000379 PPP2 +HGNC 9314 PPP3CA isa FPLX 000384 PPP3C +HGNC 9315 PPP3CB isa FPLX 000384 PPP3C +HGNC 9316 PPP3CC isa FPLX 000384 PPP3C +HGNC 9317 PPP3R1 isa FPLX 000385 PPP3R +HGNC 9318 PPP3R2 isa FPLX 000385 PPP3R +FPLX 000384 PPP3C partof FPLX 000383 PPP3 +FPLX 000385 PPP3R partof FPLX 000383 PPP3 +HGNC 9352 PRDX1 isa FPLX 000388 PRDX +HGNC 9353 PRDX2 isa FPLX 000388 PRDX +HGNC 9354 PRDX3 isa FPLX 000388 PRDX +HGNC 17169 PRDX4 isa FPLX 000388 PRDX +HGNC 9355 PRDX5 isa FPLX 000388 PRDX +HGNC 16753 PRDX6 isa FPLX 000388 PRDX +HGNC 9388 PRKAR1A isa FPLX 000390 PRKAR +HGNC 9390 PRKAR1B isa FPLX 000390 PRKAR +HGNC 9391 PRKAR2A isa FPLX 000390 PRKAR +HGNC 9392 PRKAR2B isa FPLX 000390 PRKAR +HGNC 9380 PRKACA isa FPLX 000389 PRKAC +HGNC 9381 PRKACB isa FPLX 000389 PRKAC +HGNC 9382 PRKACG isa FPLX 000389 PRKAC +FPLX 000390 PRKAR partof FPLX 000363 PKA +FPLX 000389 PRKAC partof FPLX 000363 PKA +HGNC 9393 PRKCA isa FPLX 000364 PKC +HGNC 9395 PRKCB isa FPLX 000364 PKC +HGNC 9399 PRKCD isa FPLX 000364 PKC +HGNC 9401 PRKCE isa FPLX 000364 PKC +HGNC 9402 PRKCG isa FPLX 000364 PKC +HGNC 9403 PRKCH isa FPLX 000364 PKC +HGNC 9404 PRKCI isa FPLX 000364 PKC +HGNC 9410 PRKCQ isa FPLX 000364 PKC +HGNC 9412 PRKCZ isa FPLX 000364 PKC +HGNC 9408 PRKD3 isa FPLX 000364 PKC +HGNC 9414 PRKG1 isa FPLX 000391 PRKG +HGNC 9416 PRKG2 isa FPLX 000391 PRKG +HGNC 9593 PTGER1 isa FPLX 000395 PTGER +HGNC 9594 PTGER2 isa FPLX 000395 PTGER +HGNC 9595 PTGER3 isa FPLX 000395 PTGER +HGNC 9596 PTGER4 isa FPLX 000395 PTGER +HGNC 9759 RAB10 isa FPLX 000397 RAB +HGNC 9760 RAB11A isa FPLX 000397 RAB +HGNC 9761 RAB11B isa FPLX 000397 RAB +HGNC 31332 RAB12 isa FPLX 000397 RAB +HGNC 9762 RAB13 isa FPLX 000397 RAB +HGNC 16524 RAB14 isa FPLX 000397 RAB +HGNC 20150 RAB15 isa FPLX 000397 RAB +HGNC 16523 RAB17 isa FPLX 000397 RAB +HGNC 14244 RAB18 isa FPLX 000397 RAB +HGNC 19982 RAB19 isa FPLX 000397 RAB +HGNC 9758 RAB1A isa FPLX 000397 RAB +HGNC 18370 RAB1B isa FPLX 000397 RAB +HGNC 23683 RAB1C isa FPLX 000397 RAB +HGNC 18260 RAB20 isa FPLX 000397 RAB +HGNC 18263 RAB21 isa FPLX 000397 RAB +HGNC 9764 RAB22A isa FPLX 000397 RAB +HGNC 14263 RAB23 isa FPLX 000397 RAB +HGNC 9765 RAB24 isa FPLX 000397 RAB +HGNC 18238 RAB25 isa FPLX 000397 RAB +HGNC 14259 RAB26 isa FPLX 000397 RAB +HGNC 9766 RAB27A isa FPLX 000397 RAB +HGNC 9767 RAB27B isa FPLX 000397 RAB +HGNC 9768 RAB28 isa FPLX 000397 RAB +HGNC 9763 RAB2A isa FPLX 000397 RAB +HGNC 20246 RAB2B isa FPLX 000397 RAB +HGNC 9770 RAB30 isa FPLX 000397 RAB +HGNC 9771 RAB31 isa FPLX 000397 RAB +HGNC 9772 RAB32 isa FPLX 000397 RAB +HGNC 9773 RAB33A isa FPLX 000397 RAB +HGNC 16075 RAB33B isa FPLX 000397 RAB +HGNC 16519 RAB34 isa FPLX 000397 RAB +HGNC 9774 RAB35 isa FPLX 000397 RAB +HGNC 9775 RAB36 isa FPLX 000397 RAB +HGNC 30268 RAB37 isa FPLX 000397 RAB +HGNC 9776 RAB38 isa FPLX 000397 RAB +HGNC 16521 RAB39A isa FPLX 000397 RAB +HGNC 16499 RAB39B isa FPLX 000397 RAB +HGNC 9777 RAB3A isa FPLX 000397 RAB +HGNC 9778 RAB3B isa FPLX 000397 RAB +HGNC 30269 RAB3C isa FPLX 000397 RAB +HGNC 9779 RAB3D isa FPLX 000397 RAB +HGNC 18283 RAB40A isa FPLX 000397 RAB +HGNC 25410 RAB40AL isa FPLX 000397 RAB +HGNC 18284 RAB40B isa FPLX 000397 RAB +HGNC 18285 RAB40C isa FPLX 000397 RAB +HGNC 18293 RAB41 isa FPLX 000397 RAB +HGNC 28702 RAB42 isa FPLX 000397 RAB +HGNC 19983 RAB43 isa FPLX 000397 RAB +HGNC 21068 RAB44 isa FPLX 000397 RAB +HGNC 9781 RAB4A isa FPLX 000397 RAB +HGNC 9782 RAB4B isa FPLX 000397 RAB +HGNC 9783 RAB5A isa FPLX 000397 RAB +HGNC 9784 RAB5B isa FPLX 000397 RAB +HGNC 9785 RAB5C isa FPLX 000397 RAB +HGNC 9786 RAB6A isa FPLX 000397 RAB +HGNC 14902 RAB6B isa FPLX 000397 RAB +HGNC 16525 RAB6C isa FPLX 000397 RAB +HGNC 9788 RAB7A isa FPLX 000397 RAB +HGNC 30513 RAB7B isa FPLX 000397 RAB +HGNC 9789 RAB29 isa FPLX 000397 RAB +HGNC 7007 RAB8A isa FPLX 000397 RAB +HGNC 30273 RAB8B isa FPLX 000397 RAB +HGNC 9792 RAB9A isa FPLX 000397 RAB +HGNC 14090 RAB9B isa FPLX 000397 RAB +HGNC 9799 RABL2A isa FPLX 000397 RAB +HGNC 9800 RABL2B isa FPLX 000397 RAB +HGNC 18072 RABL3 isa FPLX 000397 RAB +HGNC 21895 IFT22 isa FPLX 000397 RAB +HGNC 9864 RARA isa FPLX 000403 RAR +HGNC 9865 RARB isa FPLX 000403 RAR +HGNC 9866 RARG isa FPLX 000403 RAR +HGNC 9982 RFX1 isa FPLX 000412 RFX +HGNC 9983 RFX2 isa FPLX 000412 RFX +HGNC 9984 RFX3 isa FPLX 000412 RFX +HGNC 9985 RFX4 isa FPLX 000412 RFX +HGNC 9986 RFX5 isa FPLX 000412 RFX +HGNC 21478 RFX6 isa FPLX 000412 RFX +HGNC 25777 RFX7 isa FPLX 000412 RFX +HGNC 37253 RFX8 isa FPLX 000412 RFX +HGNC 10256 ROR1 isa FPLX 000420 ROR +HGNC 10257 ROR2 isa FPLX 000420 ROR +HGNC 10477 RXRA isa FPLX 000424 RXR +HGNC 10478 RXRB isa FPLX 000424 RXR +HGNC 10479 RXRG isa FPLX 000424 RXR +HGNC 20846 HRNR isa FPLX 000426 S100A +HGNC 10486 S100A1 isa FPLX 000426 S100A +HGNC 10487 S100A10 isa FPLX 000426 S100A +HGNC 10488 S100A11 isa FPLX 000426 S100A +HGNC 10489 S100A12 isa FPLX 000426 S100A +HGNC 10490 S100A13 isa FPLX 000426 S100A +HGNC 18901 S100A14 isa FPLX 000426 S100A +HGNC 20441 S100A16 isa FPLX 000426 S100A +HGNC 10492 S100A2 isa FPLX 000426 S100A +HGNC 10493 S100A3 isa FPLX 000426 S100A +HGNC 10494 S100A4 isa FPLX 000426 S100A +HGNC 10495 S100A5 isa FPLX 000426 S100A +HGNC 10496 S100A6 isa FPLX 000426 S100A +HGNC 10497 S100A7 isa FPLX 000426 S100A +HGNC 21657 S100A7A isa FPLX 000426 S100A +HGNC 10498 S100A8 isa FPLX 000426 S100A +HGNC 10499 S100A9 isa FPLX 000426 S100A +HGNC 31796 TCHHL1 isa FPLX 000426 S100A +FPLX 000426 S100A isa FPLX 000425 S100 +HGNC 10500 S100B isa FPLX 000425 S100 +HGNC 1436 S100G isa FPLX 000425 S100 +HGNC 10504 S100P isa FPLX 000425 S100 +HGNC 30367 S100Z isa FPLX 000425 S100 +HGNC 3165 S1PR1 isa FPLX 000427 S1PR +HGNC 3169 S1PR2 isa FPLX 000427 S1PR +HGNC 3167 S1PR3 isa FPLX 000427 S1PR +HGNC 3170 S1PR4 isa FPLX 000427 S1PR +HGNC 14299 S1PR5 isa FPLX 000427 S1PR +HGNC 10571 SCD isa FPLX 000429 SCD +HGNC 21088 SCD5 isa FPLX 000429 SCD +HGNC 3311 SERPINB1 isa FPLX 000431 SERPINB +HGNC 8584 SERPINB2 isa FPLX 000431 SERPINB +HGNC 10569 SERPINB3 isa FPLX 000431 SERPINB +HGNC 10570 SERPINB4 isa FPLX 000431 SERPINB +HGNC 8949 SERPINB5 isa FPLX 000431 SERPINB +HGNC 8950 SERPINB6 isa FPLX 000431 SERPINB +HGNC 13902 SERPINB7 isa FPLX 000431 SERPINB +HGNC 8952 SERPINB8 isa FPLX 000431 SERPINB +HGNC 8955 SERPINB9 isa FPLX 000431 SERPINB +HGNC 8942 SERPINB10 isa FPLX 000431 SERPINB +HGNC 14221 SERPINB11 isa FPLX 000431 SERPINB +HGNC 14220 SERPINB12 isa FPLX 000431 SERPINB +HGNC 8944 SERPINB13 isa FPLX 000431 SERPINB +HGNC 11005 SLC2A1 isa FPLX 000434 SLC2A +HGNC 11006 SLC2A2 isa FPLX 000434 SLC2A +HGNC 11007 SLC2A3 isa FPLX 000434 SLC2A +HGNC 11009 SLC2A4 isa FPLX 000434 SLC2A +HGNC 11010 SLC2A5 isa FPLX 000434 SLC2A +HGNC 11011 SLC2A6 isa FPLX 000434 SLC2A +HGNC 13445 SLC2A7 isa FPLX 000434 SLC2A +HGNC 13812 SLC2A8 isa FPLX 000434 SLC2A +HGNC 13446 SLC2A9 isa FPLX 000434 SLC2A +HGNC 13444 SLC2A10 isa FPLX 000434 SLC2A +HGNC 14239 SLC2A11 isa FPLX 000434 SLC2A +HGNC 18067 SLC2A12 isa FPLX 000434 SLC2A +HGNC 18301 SLC2A14 isa FPLX 000434 SLC2A +HGNC 6767 SMAD1 isa FPLX 000441 SMAD +HGNC 6767 SMAD1 isa FPLX 000442 SMAD1_5_9 +HGNC 6768 SMAD2 isa FPLX 000443 SMAD2_3 +HGNC 6769 SMAD3 isa FPLX 000443 SMAD2_3 +HGNC 6770 SMAD4 isa FPLX 000441 SMAD +HGNC 6771 SMAD5 isa FPLX 000441 SMAD +HGNC 6771 SMAD5 isa FPLX 000442 SMAD1_5_9 +HGNC 6772 SMAD6 isa FPLX 000441 SMAD +HGNC 6773 SMAD7 isa FPLX 000441 SMAD +HGNC 6774 SMAD9 isa FPLX 000441 SMAD +HGNC 6774 SMAD9 isa FPLX 000442 SMAD1_5_9 +FPLX 000443 SMAD2_3 isa FPLX 000441 SMAD +FPLX 000442 SMAD1_5_9 isa FPLX 000441 SMAD +HGNC 11111 SMC1A isa FPLX 000444 SMC1 +HGNC 11112 SMC1B isa FPLX 000444 SMC1 +HGNC 11128 SNAI1 isa FPLX 000446 SNAI +HGNC 11094 SNAI2 isa FPLX 000446 SNAI +HGNC 18411 SNAI3 isa FPLX 000446 SNAI +HGNC 3697 FGR isa FPLX 000451 SRC +HGNC 4037 FYN isa FPLX 000451 SRC +HGNC 11283 SRC isa FPLX 000451 SRC +HGNC 12841 YES1 isa FPLX 000451 SRC +HGNC 11289 SREBF1 isa FPLX 000452 SREBF +HGNC 11290 SREBF2 isa FPLX 000452 SREBF +HGNC 43 TAP1 isa FPLX 000459 TAP +HGNC 44 TAP2 isa FPLX 000459 TAP +HGNC 50 ABCB9 isa FPLX 000459 TAP +HGNC 6551 LEF1 isa FPLX 000460 TCF_LEF +HGNC 11639 TCF7 isa FPLX 000460 TCF_LEF +HGNC 11640 TCF7L1 isa FPLX 000460 TCF_LEF +HGNC 11641 TCF7L2 isa FPLX 000460 TCF_LEF +HGNC 11742 TFAP2A isa FPLX 000463 TFAP2 +HGNC 11743 TFAP2B isa FPLX 000463 TFAP2 +HGNC 11744 TFAP2C isa FPLX 000463 TFAP2 +HGNC 15581 TFAP2D isa FPLX 000463 TFAP2 +HGNC 30774 TFAP2E isa FPLX 000463 TFAP2 +HGNC 11766 TGFB1 isa FPLX 000465 TGFB +HGNC 11768 TGFB2 isa FPLX 000465 TGFB +HGNC 11769 TGFB3 isa FPLX 000465 TGFB +HGNC 11772 TGFBR1 isa FPLX 000466 TGFBR +HGNC 11773 TGFBR2 isa FPLX 000466 TGFBR +HGNC 11774 TGFBR3 isa FPLX 000466 TGFBR +HGNC 11785 THBS1 isa FPLX 000467 THBS +HGNC 11786 THBS2 isa FPLX 000467 THBS +HGNC 11787 THBS3 isa FPLX 000467 THBS +HGNC 11788 THBS4 isa FPLX 000467 THBS +HGNC 2227 COMP isa FPLX 000467 THBS +HGNC 11796 THRA isa FPLX 000468 THR +HGNC 11799 THRB isa FPLX 000468 THR +HGNC 5318 TNC isa FPLX 000473 TN +HGNC 22942 TNN isa FPLX 000473 TN +HGNC 11953 TNR isa FPLX 000473 TN +HGNC 11976 TNXB isa FPLX 000473 TN +HGNC 11989 TOP2A isa FPLX 000476 TOP2 +HGNC 11990 TOP2B isa FPLX 000476 TOP2 +HGNC 12019 TPSAB1 isa FPLX 000481 Tryptase +HGNC 14120 TPSB2 isa FPLX 000481 Tryptase +HGNC 14118 TPSD1 isa FPLX 000481 Tryptase +HGNC 14134 TPSG1 isa FPLX 000481 Tryptase +HGNC 12435 TXN isa FPLX 000487 TXN +HGNC 17772 TXN2 isa FPLX 000487 TXN +HGNC 12437 TXNRD1 isa FPLX 000488 TXNRD +HGNC 18155 TXNRD2 isa FPLX 000488 TXNRD +HGNC 20667 TXNRD3 isa FPLX 000488 TXNRD +HGNC 1734 CDC34 isa FPLX 000489 UBE2 +HGNC 12472 UBE2A isa FPLX 000489 UBE2 +HGNC 12473 UBE2B isa FPLX 000489 UBE2 +HGNC 15937 UBE2C isa FPLX 000489 UBE2 +HGNC 12474 UBE2D1 isa FPLX 000489 UBE2 +HGNC 12475 UBE2D2 isa FPLX 000489 UBE2 +HGNC 12476 UBE2D3 isa FPLX 000489 UBE2 +HGNC 21647 UBE2D4 isa FPLX 000489 UBE2 +HGNC 12477 UBE2E1 isa FPLX 000489 UBE2 +HGNC 12478 UBE2E2 isa FPLX 000489 UBE2 +HGNC 12479 UBE2E3 isa FPLX 000489 UBE2 +HGNC 12480 UBE2F isa FPLX 000489 UBE2 +HGNC 12482 UBE2G1 isa FPLX 000489 UBE2 +HGNC 12483 UBE2G2 isa FPLX 000489 UBE2 +HGNC 12484 UBE2H isa FPLX 000489 UBE2 +HGNC 12485 UBE2I isa FPLX 000489 UBE2 +HGNC 17598 UBE2J1 isa FPLX 000489 UBE2 +HGNC 19268 UBE2J2 isa FPLX 000489 UBE2 +HGNC 12488 UBE2L3 isa FPLX 000489 UBE2 +HGNC 12490 UBE2L6 isa FPLX 000489 UBE2 +HGNC 12491 UBE2M isa FPLX 000489 UBE2 +HGNC 12492 UBE2N isa FPLX 000489 UBE2 +HGNC 31710 UBE2NL isa FPLX 000489 UBE2 +HGNC 15698 UBE2Q1 isa FPLX 000489 UBE2 +HGNC 19907 UBE2R2 isa FPLX 000489 UBE2 +HGNC 17895 UBE2S isa FPLX 000489 UBE2 +HGNC 12494 UBE2V1 isa FPLX 000489 UBE2 +HGNC 12495 UBE2V2 isa FPLX 000489 UBE2 +HGNC 25616 UBE2W isa FPLX 000489 UBE2 +HGNC 12657 VAV1 isa FPLX 000494 VAV +HGNC 12658 VAV2 isa FPLX 000494 VAV +HGNC 12659 VAV3 isa FPLX 000494 VAV +HGNC 12680 VEGFA isa FPLX 000495 VEGF +HGNC 12681 VEGFB isa FPLX 000495 VEGF +HGNC 12682 VEGFC isa FPLX 000495 VEGF +HGNC 3708 VEGFD isa FPLX 000495 VEGF +HGNC 8893 PGF isa FPLX 000495 VEGF +HGNC 3763 FLT1 isa FPLX 000496 VEGFR +HGNC 3767 FLT4 isa FPLX 000496 VEGFR +HGNC 6307 KDR isa FPLX 000496 VEGFR +HGNC 76 ABL1 isa FPLX 000003 ABL_family +HGNC 77 ABL2 isa FPLX 000003 ABL_family +HGNC 5309 HUS1 partof FPLX 000001 9_1_1 +HGNC 9806 RAD1 partof FPLX 000001 9_1_1 +HGNC 9827 RAD9A partof FPLX 000001 9_1_1 +HGNC 566 AP3B1 partof FPLX 000016 Adaptor_protein_III +HGNC 568 AP3D1 partof FPLX 000016 Adaptor_protein_III +HGNC 2013 AP3S1 partof FPLX 000016 Adaptor_protein_III +HGNC 571 AP3S2 partof FPLX 000016 Adaptor_protein_III +HGNC 537 ANXA2 partof FPLX 000047 Annexin_II_heterotetramer +HGNC 10487 S100A10 partof FPLX 000047 Annexin_II_heterotetramer +HGNC 703 ARPC1A partof FPLX 000054 Arp2_3_protein +HGNC 704 ARPC1B partof FPLX 000054 Arp2_3_protein +HGNC 705 ARPC2 partof FPLX 000054 Arp2_3_protein +HGNC 706 ARPC3 partof FPLX 000054 Arp2_3_protein +HGNC 707 ARPC4 partof FPLX 000054 Arp2_3_protein +HGNC 708 ARPC5 partof FPLX 000054 Arp2_3_protein +HGNC 23366 ARPC5L partof FPLX 000054 Arp2_3_protein +HGNC 986 BCKDHA partof FPLX 000064 BCKDC +HGNC 987 BCKDHB partof FPLX 000064 BCKDC +HGNC 2698 DBT partof FPLX 000064 BCKDC +HGNC 2898 DLD partof FPLX 000064 BCKDC +HGNC 1241 C1QA partof FPLX 000072 C1 +HGNC 1242 C1QB partof FPLX 000072 C1 +HGNC 1245 C1QC partof FPLX 000072 C1 +HGNC 1246 C1R partof FPLX 000072 C1 +HGNC 1247 C1S partof FPLX 000072 C1 +HGNC 1241 C1QA partof FPLX 000073 C1q +HGNC 1242 C1QB partof FPLX 000073 C1q +HGNC 1460 CAMK2A partof FPLX 000077 CAMK2_complex +HGNC 1461 CAMK2B partof FPLX 000077 CAMK2_complex +HGNC 1462 CAMK2D partof FPLX 000077 CAMK2_complex +HGNC 1463 CAMK2G partof FPLX 000077 CAMK2_complex +HGNC 10899 SKP1 partof FPLX 000084 CBF3 +HGNC 1615 CCT2 partof FPLX 000085 CCT_complex +HGNC 1616 CCT3 partof FPLX 000085 CCT_complex +HGNC 1617 CCT4 partof FPLX 000085 CCT_complex +HGNC 1618 CCT5 partof FPLX 000085 CCT_complex +HGNC 1620 CCT6A partof FPLX 000085 CCT_complex +HGNC 1621 CCT6B partof FPLX 000085 CCT_complex +HGNC 1622 CCT7 partof FPLX 000085 CCT_complex +HGNC 1623 CCT8 partof FPLX 000085 CCT_complex +HGNC 11655 TCP1 partof FPLX 000085 CCT_complex +HGNC 1677 CD247 partof FPLX 000087 CD3 +HGNC 1673 CD3D partof FPLX 000087 CD3 +HGNC 1674 CD3E partof FPLX 000087 CD3 +HGNC 1675 CD3G partof FPLX 000087 CD3 +HGNC 1956 CHRNA2 partof FPLX 000103 CHRN +HGNC 1957 CHRNA3 partof FPLX 000103 CHRN +HGNC 1958 CHRNA4 partof FPLX 000103 CHRN +HGNC 1959 CHRNA5 partof FPLX 000103 CHRN +HGNC 15963 CHRNA6 partof FPLX 000103 CHRN +HGNC 1960 CHRNA7 partof FPLX 000103 CHRN +HGNC 1962 CHRNB2 partof FPLX 000103 CHRN +HGNC 1963 CHRNB3 partof FPLX 000103 CHRN +HGNC 1964 CHRNB4 partof FPLX 000103 CHRN +HGNC 2090 CLTA partof FPLX 000105 Clathrin +HGNC 2091 CLTB partof FPLX 000105 Clathrin +HGNC 2092 CLTC partof FPLX 000105 Clathrin +HGNC 9811 RAD21 partof FPLX 000108 Cohesin +HGNC 2468 SMC3 partof FPLX 000108 Cohesin +HGNC 9234 MED1 partof FPLX 000122 CRSP +HGNC 2370 MED14 partof FPLX 000122 CRSP +HGNC 2375 MED17 partof FPLX 000122 CRSP +HGNC 2372 MED23 partof FPLX 000122 CRSP +HGNC 2376 MED26 partof FPLX 000122 CRSP +HGNC 2377 MED27 partof FPLX 000122 CRSP +HGNC 2378 MED7 partof FPLX 000122 CRSP +HGNC 2961 DYNC1H1 partof FPLX 000135 Cytoplasmic_dynein +HGNC 2963 DYNC1I1 partof FPLX 000135 Cytoplasmic_dynein +HGNC 2964 DYNC1I2 partof FPLX 000135 Cytoplasmic_dynein +HGNC 18745 DYNC1LI1 partof FPLX 000135 Cytoplasmic_dynein +HGNC 2966 DYNC1LI2 partof FPLX 000135 Cytoplasmic_dynein +HGNC 15476 DYNLL1 partof FPLX 000135 Cytoplasmic_dynein +HGNC 15468 DYNLRB1 partof FPLX 000135 Cytoplasmic_dynein +HGNC 15467 DYNLRB2 partof FPLX 000135 Cytoplasmic_dynein +HGNC 9175 POLD1 partof FPLX 000141 DNA_polymerase_delta +HGNC 9176 POLD2 partof FPLX 000141 DNA_polymerase_delta +HGNC 20932 POLD3 partof FPLX 000141 DNA_polymerase_delta +HGNC 14106 POLD4 partof FPLX 000141 DNA_polymerase_delta +HGNC 2666 DAG1 partof FPLX 000139 DGC +HGNC 2928 DMD partof FPLX 000139 DGC +HGNC 3057 DTNA partof FPLX 000139 DGC +HGNC 3058 DTNB partof FPLX 000139 DGC +HGNC 7872 NOS1 partof FPLX 000139 DGC +HGNC 10805 SGCA partof FPLX 000139 DGC +HGNC 10806 SGCB partof FPLX 000139 DGC +HGNC 10807 SGCD partof FPLX 000139 DGC +HGNC 10808 SGCE partof FPLX 000139 DGC +HGNC 14075 SGCZ partof FPLX 000139 DGC +HGNC 11167 SNTA1 partof FPLX 000139 DGC +HGNC 11168 SNTB1 partof FPLX 000139 DGC +HGNC 13740 SNTG1 partof FPLX 000139 DGC +HGNC 13741 SNTG2 partof FPLX 000139 DGC +HGNC 11322 SSPN partof FPLX 000139 DGC +HGNC 12635 UTRN partof FPLX 000139 DGC +HGNC 3257 EIF2B1 partof FPLX 000152 EIF2B +HGNC 3258 EIF2B2 partof FPLX 000152 EIF2B +HGNC 3259 EIF2B3 partof FPLX 000152 EIF2B +HGNC 3260 EIF2B4 partof FPLX 000152 EIF2B +HGNC 3261 EIF2B5 partof FPLX 000152 EIF2B +HGNC 3661 FGA partof FPLX 000169 Fibrinogen +HGNC 3662 FGB partof FPLX 000169 Fibrinogen +HGNC 3694 FGG partof FPLX 000169 Fibrinogen +HGNC 1885 CGA partof FPLX 000175 FSH +HGNC 3964 FSHB partof FPLX 000175 FSH +HGNC 29509 APH1A partof FPLX 000181 Gamma_secretase +HGNC 9508 PSEN1 partof FPLX 000181 Gamma_secretase +HGNC 30100 PSENEN partof FPLX 000181 Gamma_secretase +HGNC 4446 GPAA1 partof FPLX 000189 GPIT +HGNC 8965 PIGK partof FPLX 000189 GPIT +HGNC 14937 PIGS partof FPLX 000189 GPIT +HGNC 14938 PIGT partof FPLX 000189 GPIT +HGNC 15791 PIGU partof FPLX 000189 GPIT +HGNC 4650 GTF2E1 partof FPLX 000196 GTF2E +HGNC 4651 GTF2E2 partof FPLX 000196 GTF2E +HGNC 4652 GTF2F1 partof FPLX 000197 GTF2F +HGNC 4653 GTF2F2 partof FPLX 000197 GTF2F +HGNC 399 ALB partof FPLX 000225 HDL +HGNC 600 APOA1 partof FPLX 000225 HDL +HGNC 601 APOA2 partof FPLX 000225 HDL +HGNC 613 APOE partof FPLX 000225 HDL +HGNC 2095 CLU partof FPLX 000225 HDL +HGNC 4823 HBA1 partof FPLX 000227 Hemoglobin +HGNC 4824 HBA2 partof FPLX 000227 Hemoglobin +HGNC 4827 HBB partof FPLX 000227 Hemoglobin +HGNC 4829 HBD partof FPLX 000227 Hemoglobin +HGNC 4830 HBE1 partof FPLX 000227 Hemoglobin +HGNC 4831 HBG1 partof FPLX 000227 Hemoglobin +HGNC 4832 HBG2 partof FPLX 000227 Hemoglobin +HGNC 4826 HBM partof FPLX 000227 Hemoglobin +HGNC 4833 HBQ1 partof FPLX 000227 Hemoglobin +HGNC 4835 HBZ partof FPLX 000227 Hemoglobin +HGNC 4439 GP1BA partof FPLX 000188 GPIb_IX_V +HGNC 4440 GP1BB partof FPLX 000188 GPIb_IX_V +HGNC 4443 GP5 partof FPLX 000188 GPIb_IX_V +HGNC 4444 GP9 partof FPLX 000188 GPIb_IX_V +HGNC 1974 CHUK partof FPLX 000250 IKK_complex +HGNC 5960 IKBKB partof FPLX 000250 IKK_complex +HGNC 5961 IKBKG partof FPLX 000250 IKK_complex +HGNC 5439 IFNGR1 partof FPLX 000263 Interferon_gamma_receptor +HGNC 5440 IFNGR2 partof FPLX 000263 Interferon_gamma_receptor +HGNC 1148 BUB1 partof FPLX 000270 Kinetochore +HGNC 1149 BUB1B partof FPLX 000270 Kinetochore +HGNC 1151 BUB3 partof FPLX 000270 Kinetochore +HGNC 1854 CENPC partof FPLX 000270 Kinetochore +HGNC 1856 CENPE partof FPLX 000270 Kinetochore +HGNC 1857 CENPF partof FPLX 000270 Kinetochore +HGNC 17268 CENPH partof FPLX 000270 Kinetochore +HGNC 2712 DCTN2 partof FPLX 000270 Kinetochore +HGNC 6391 KIF22 partof FPLX 000270 Kinetochore +HGNC 6763 MAD2L1 partof FPLX 000270 Kinetochore +HGNC 8574 PAFAH1B1 partof FPLX 000270 Kinetochore +HGNC 9508 PSEN1 partof FPLX 000270 Kinetochore +HGNC 9509 PSEN2 partof FPLX 000270 Kinetochore +HGNC 11111 SMC1A partof FPLX 000270 Kinetochore +HGNC 16987 SUGT1 partof FPLX 000270 Kinetochore +HGNC 11124 SUMO3 partof FPLX 000270 Kinetochore +HGNC 13194 ZW10 partof FPLX 000270 Kinetochore +HGNC 6481 LAMA1 partof FPLX 000273 Laminin_111 +HGNC 6486 LAMB1 partof FPLX 000273 Laminin_111 +HGNC 6492 LAMC1 partof FPLX 000273 Laminin_111 +HGNC 6483 LAMA3 partof FPLX 000274 Laminin_332 +HGNC 6490 LAMB3 partof FPLX 000274 Laminin_332 +HGNC 6493 LAMC2 partof FPLX 000274 Laminin_332 +HGNC 1885 CGA partof FPLX 000276 LH +HGNC 6584 LHB partof FPLX 000276 LH +HGNC 1331 C5 partof FPLX 000278 MAC +HGNC 1339 C6 partof FPLX 000278 MAC +HGNC 1346 C7 partof FPLX 000278 MAC +HGNC 1352 C8A partof FPLX 000278 MAC +HGNC 1353 C8B partof FPLX 000278 MAC +HGNC 1354 C8G partof FPLX 000278 MAC +HGNC 1358 C9 partof FPLX 000278 MAC +HGNC 799 ATP1A1 isa FPLX 000057 ATP1A +HGNC 800 ATP1A2 isa FPLX 000057 ATP1A +HGNC 801 ATP1A3 isa FPLX 000057 ATP1A +HGNC 14073 ATP1A4 isa FPLX 000057 ATP1A +HGNC 804 ATP1B1 isa FPLX 000058 ATP1B +HGNC 805 ATP1B2 isa FPLX 000058 ATP1B +HGNC 806 ATP1B3 isa FPLX 000058 ATP1B +HGNC 808 ATP1B4 isa FPLX 000058 ATP1B +FPLX 000057 ATP1A partof FPLX 000303 Na_K_ATPase +FPLX 000058 ATP1B partof FPLX 000303 Na_K_ATPase +HGNC 7455 MT-ND1 partof FPLX 000301 NADH_dehydrogenase +HGNC 7456 MT-ND2 partof FPLX 000301 NADH_dehydrogenase +HGNC 7458 MT-ND3 partof FPLX 000301 NADH_dehydrogenase +HGNC 7459 MT-ND4 partof FPLX 000301 NADH_dehydrogenase +HGNC 7460 MT-ND4L partof FPLX 000301 NADH_dehydrogenase +HGNC 7461 MT-ND5 partof FPLX 000301 NADH_dehydrogenase +HGNC 7462 MT-ND6 partof FPLX 000301 NADH_dehydrogenase +HGNC 2577 CYBA partof FPLX 000302 NADPH_oxidase +HGNC 2578 CYBB partof FPLX 000302 NADPH_oxidase +HGNC 3062 DUOX1 partof FPLX 000302 NADPH_oxidase +HGNC 13273 DUOX2 partof FPLX 000302 NADPH_oxidase +HGNC 7660 NCF1 partof FPLX 000302 NADPH_oxidase +HGNC 7661 NCF2 partof FPLX 000302 NADPH_oxidase +HGNC 7662 NCF4 partof FPLX 000302 NADPH_oxidase +HGNC 7889 NOX1 partof FPLX 000302 NADPH_oxidase +HGNC 7890 NOX3 partof FPLX 000302 NADPH_oxidase +HGNC 7891 NOX4 partof FPLX 000302 NADPH_oxidase +HGNC 14874 NOX5 partof FPLX 000302 NADPH_oxidase +HGNC 9801 RAC1 partof FPLX 000302 NADPH_oxidase +HGNC 7804 NFYA partof FPLX 000314 NFY +HGNC 7805 NFYB partof FPLX 000314 NFY +HGNC 7806 NFYC partof FPLX 000314 NFY +HGNC 1442 CALM1 partof FPLX 000356 PhK +HGNC 8925 PHKA1 partof FPLX 000356 PhK +HGNC 8926 PHKA2 partof FPLX 000356 PhK +HGNC 8927 PHKB partof FPLX 000356 PhK +HGNC 8930 PHKG1 partof FPLX 000356 PhK +HGNC 8931 PHKG2 partof FPLX 000356 PhK +HGNC 1066 BMI1 partof FPLX 000386 PRC1_complex +HGNC 1552 CBX2 partof FPLX 000386 PRC1_complex +HGNC 1554 CBX4 partof FPLX 000386 PRC1_complex +HGNC 15962 CBX8 partof FPLX 000386 PRC1_complex +HGNC 12929 PCGF2 partof FPLX 000386 PRC1_complex +HGNC 3182 PHC1 partof FPLX 000386 PRC1_complex +HGNC 3183 PHC2 partof FPLX 000386 PRC1_complex +HGNC 15682 PHC3 partof FPLX 000386 PRC1_complex +HGNC 8919 PHF1 partof FPLX 000386 PRC1_complex +HGNC 10018 RING1 partof FPLX 000386 PRC1_complex +HGNC 10061 RNF2 partof FPLX 000386 PRC1_complex +HGNC 19003 SCMH1 partof FPLX 000386 PRC1_complex +HGNC 12856 YY1 partof FPLX 000386 PRC1_complex +HGNC 12918 ZNF134 partof FPLX 000386 PRC1_complex +HGNC 3188 EED partof FPLX 000387 PRC2_complex +HGNC 3526 EZH1 partof FPLX 000387 PRC2_complex +HGNC 3527 EZH2 partof FPLX 000387 PRC2_complex +HGNC 17101 SUZ12 partof FPLX 000387 PRC2_complex +HGNC 8653 PCCA partof FPLX 000392 Propionyl_CoA_carboxylase +HGNC 8654 PCCB partof FPLX 000392 Propionyl_CoA_carboxylase +HGNC 9530 PSMA1 partof FPLX 000394 Proteasome +HGNC 9531 PSMA2 partof FPLX 000394 Proteasome +HGNC 9532 PSMA3 partof FPLX 000394 Proteasome +HGNC 9533 PSMA4 partof FPLX 000394 Proteasome +HGNC 9534 PSMA5 partof FPLX 000394 Proteasome +HGNC 9535 PSMA6 partof FPLX 000394 Proteasome +HGNC 9536 PSMA7 partof FPLX 000394 Proteasome +HGNC 22985 PSMA8 partof FPLX 000394 Proteasome +HGNC 9537 PSMB1 partof FPLX 000394 Proteasome +HGNC 9538 PSMB10 partof FPLX 000394 Proteasome +HGNC 9539 PSMB2 partof FPLX 000394 Proteasome +HGNC 9540 PSMB3 partof FPLX 000394 Proteasome +HGNC 9541 PSMB4 partof FPLX 000394 Proteasome +HGNC 9542 PSMB5 partof FPLX 000394 Proteasome +HGNC 9543 PSMB6 partof FPLX 000394 Proteasome +HGNC 9544 PSMB7 partof FPLX 000394 Proteasome +HGNC 9545 PSMB8 partof FPLX 000394 Proteasome +HGNC 9546 PSMB9 partof FPLX 000394 Proteasome +HGNC 9547 PSMC1 partof FPLX 000394 Proteasome +HGNC 9548 PSMC2 partof FPLX 000394 Proteasome +HGNC 9549 PSMC3 partof FPLX 000394 Proteasome +HGNC 9551 PSMC4 partof FPLX 000394 Proteasome +HGNC 9552 PSMC5 partof FPLX 000394 Proteasome +HGNC 9553 PSMC6 partof FPLX 000394 Proteasome +HGNC 9554 PSMD1 partof FPLX 000394 Proteasome +HGNC 9555 PSMD10 partof FPLX 000394 Proteasome +HGNC 9556 PSMD11 partof FPLX 000394 Proteasome +HGNC 9557 PSMD12 partof FPLX 000394 Proteasome +HGNC 9558 PSMD13 partof FPLX 000394 Proteasome +HGNC 16889 PSMD14 partof FPLX 000394 Proteasome +HGNC 9559 PSMD2 partof FPLX 000394 Proteasome +HGNC 9560 PSMD3 partof FPLX 000394 Proteasome +HGNC 9561 PSMD4 partof FPLX 000394 Proteasome +HGNC 9563 PSMD5 partof FPLX 000394 Proteasome +HGNC 9564 PSMD6 partof FPLX 000394 Proteasome +HGNC 9565 PSMD7 partof FPLX 000394 Proteasome +HGNC 9566 PSMD8 partof FPLX 000394 Proteasome +HGNC 9567 PSMD9 partof FPLX 000394 Proteasome +HGNC 9568 PSME1 partof FPLX 000394 Proteasome +HGNC 9569 PSME2 partof FPLX 000394 Proteasome +HGNC 9570 PSME3 partof FPLX 000394 Proteasome +HGNC 9571 PSMF1 partof FPLX 000394 Proteasome +HGNC 10845 SEM1 partof FPLX 000394 Proteasome +HGNC 12628 USP5 partof FPLX 000394 Proteasome +HGNC 2896 DLAT partof FPLX 000352 PDH +HGNC 2898 DLD partof FPLX 000352 PDH +HGNC 8806 PDHA1 partof FPLX 000352 PDH +HGNC 8807 PDHA2 partof FPLX 000352 PDH +HGNC 8808 PDHB partof FPLX 000352 PDH +HGNC 21350 PDHX partof FPLX 000352 PDH +HGNC 9969 RFC1 partof FPLX 000411 RFC +HGNC 9970 RFC2 partof FPLX 000411 RFC +HGNC 9971 RFC3 partof FPLX 000411 RFC +HGNC 9972 RFC4 partof FPLX 000411 RFC +HGNC 9973 RFC5 partof FPLX 000411 RFC +HGNC 17264 POLR1A partof FPLX 000416 RNApo_I +HGNC 20454 POLR1B partof FPLX 000416 RNApo_I +HGNC 20194 POLR1C partof FPLX 000416 RNApo_I +HGNC 20422 POLR1D partof FPLX 000416 RNApo_I +HGNC 9187 POLR2A partof FPLX 000417 RNApo_II +HGNC 9188 POLR2B partof FPLX 000417 RNApo_II +HGNC 9189 POLR2C partof FPLX 000417 RNApo_II +HGNC 9191 POLR2D partof FPLX 000417 RNApo_II +HGNC 9192 POLR2E partof FPLX 000417 RNApo_II +HGNC 9193 POLR2F partof FPLX 000417 RNApo_II +HGNC 9194 POLR2G partof FPLX 000417 RNApo_II +HGNC 9195 POLR2H partof FPLX 000417 RNApo_II +HGNC 9196 POLR2I partof FPLX 000417 RNApo_II +HGNC 9197 POLR2J partof FPLX 000417 RNApo_II +HGNC 23208 POLR2J2 partof FPLX 000417 RNApo_II +HGNC 9198 POLR2K partof FPLX 000417 RNApo_II +HGNC 9199 POLR2L partof FPLX 000417 RNApo_II +HGNC 3535 F2 partof FPLX 000469 Thrombin_antithrombin +HGNC 775 SERPINC1 partof FPLX 000469 Thrombin_antithrombin +HGNC 11532 TAF1A partof FPLX 000471 TIF_IB +HGNC 11533 TAF1B partof FPLX 000471 TIF_IB +HGNC 11534 TAF1C partof FPLX 000471 TIF_IB +HGNC 11588 TBP partof FPLX 000471 TIF_IB +HGNC 18752 MAPKAP1 partof FPLX 000294 mTORC2 +HGNC 3942 MTOR partof FPLX 000294 mTORC2 +HGNC 28611 RICTOR partof FPLX 000294 mTORC2 +HGNC 24825 MLST8 partof FPLX 000294 mTORC2 +HGNC 3942 MTOR partof FPLX 000293 mTORC1 +HGNC 30287 RPTOR partof FPLX 000293 mTORC1 +HGNC 11998 TP53 isa FPLX 000327 p53_family +HGNC 15979 TP63 isa FPLX 000327 p53_family +HGNC 12003 TP73 isa FPLX 000327 p53_family +HGNC 9585 PTCH1 isa FPLX 000333 Patched +HGNC 9586 PTCH2 isa FPLX 000333 Patched +HGNC 11943 TNNC1 isa FPLX 000478 Troponin_C +HGNC 11944 TNNC2 isa FPLX 000478 Troponin_C +HGNC 11945 TNNI1 isa FPLX 000479 Troponin_I +HGNC 11946 TNNI2 isa FPLX 000479 Troponin_I +HGNC 11947 TNNI3 isa FPLX 000479 Troponin_I +HGNC 11948 TNNT1 isa FPLX 000480 Troponin_T +HGNC 11949 TNNT2 isa FPLX 000480 Troponin_T +HGNC 11950 TNNT3 isa FPLX 000480 Troponin_T +FPLX 000478 Troponin_C partof FPLX 000477 Troponin +FPLX 000479 Troponin_I partof FPLX 000477 Troponin +FPLX 000480 Troponin_T partof FPLX 000477 Troponin +HGNC 811 ATP2A1 isa FPLX 000430 SERCA +HGNC 812 ATP2A2 isa FPLX 000430 SERCA +HGNC 813 ATP2A3 isa FPLX 000430 SERCA +HGNC 8014 YBX1 isa FPLX 000498 YBX +HGNC 17948 YBX2 isa FPLX 000498 YBX +HGNC 2428 YBX3 isa FPLX 000498 YBX +HGNC 1925 CHEK1 isa FPLX 000098 CHEK +HGNC 16627 CHEK2 isa FPLX 000098 CHEK +HGNC 270 PARP1 isa FPLX 000331 PARP +HGNC 272 PARP2 isa FPLX 000331 PARP +HGNC 273 PARP3 isa FPLX 000331 PARP +HGNC 271 PARP4 isa FPLX 000331 PARP +HGNC 26921 PARP6 isa FPLX 000331 PARP +HGNC 26124 PARP8 isa FPLX 000331 PARP +HGNC 24118 PARP9 isa FPLX 000331 PARP +HGNC 25895 PARP10 isa FPLX 000331 PARP +HGNC 1186 PARP11 isa FPLX 000331 PARP +HGNC 21919 PARP12 isa FPLX 000331 PARP +HGNC 29232 PARP14 isa FPLX 000331 PARP +HGNC 26876 PARP15 isa FPLX 000331 PARP +HGNC 26040 PARP16 isa FPLX 000331 PARP +HGNC 11941 TNKS isa FPLX 000331 PARP +HGNC 15677 TNKS2 isa FPLX 000331 PARP +HGNC 23696 TIPARP isa FPLX 000331 PARP +HGNC 7781 NFE2L1 isa FPLX 000310 NFE +HGNC 7782 NFE2L2 isa FPLX 000310 NFE +HGNC 7783 NFE2L3 isa FPLX 000310 NFE +HGNC 1784 CDKN1A isa FPLX 000095 CDKN1 +HGNC 1785 CDKN1B isa FPLX 000095 CDKN1 +HGNC 1786 CDKN1C isa FPLX 000095 CDKN1 +HGNC 1787 CDKN2A isa FPLX 000096 CDKN2 +HGNC 1788 CDKN2B isa FPLX 000096 CDKN2 +HGNC 1789 CDKN2C isa FPLX 000096 CDKN2 +HGNC 1790 CDKN2D isa FPLX 000096 CDKN2 +FPLX 000095 CDKN1 isa FPLX 000094 CDKN +FPLX 000096 CDKN2 isa FPLX 000094 CDKN +HGNC 1791 CDKN3 isa FPLX 000094 CDKN +HGNC 678 ARHGDIA isa FPLX 000415 RhoGDI +HGNC 679 ARHGDIB isa FPLX 000415 RhoGDI +HGNC 680 ARHGDIG isa FPLX 000415 RhoGDI +HGNC 10289 RPA1 partof FPLX 000421 RPA +HGNC 10290 RPA2 partof FPLX 000421 RPA +HGNC 10291 RPA3 partof FPLX 000421 RPA +HGNC 12027 TRA partof FPLX 000461 TCR +HGNC 12155 TRB partof FPLX 000461 TCR +HGNC 12252 TRD partof FPLX 000461 TCR +HGNC 12271 TRG partof FPLX 000461 TCR +HGNC 10249 ROBO1 isa FPLX 000418 ROBO +HGNC 10250 ROBO2 isa FPLX 000418 ROBO +HGNC 13433 ROBO3 isa FPLX 000418 ROBO +HGNC 11714 TEAD1 isa FPLX 000462 TEAD +HGNC 11715 TEAD2 isa FPLX 000462 TEAD +HGNC 11716 TEAD3 isa FPLX 000462 TEAD +HGNC 11717 TEAD4 isa FPLX 000462 TEAD +HGNC 16807 SMURF1 isa FPLX 000445 SMURF +HGNC 16809 SMURF2 isa FPLX 000445 SMURF +HGNC 3166 LPAR1 isa FPLX 000277 LPAR +HGNC 3168 LPAR2 isa FPLX 000277 LPAR +HGNC 14298 LPAR3 isa FPLX 000277 LPAR +HGNC 1044 BGN isa FPLX 000436 SLRP_1 +HGNC 2705 DCN isa FPLX 000436 SLRP_1 +HGNC 14872 ASPN isa FPLX 000436 SLRP_1 +HGNC 3154 ECM2 isa FPLX 000436 SLRP_1 +HGNC 3774 FMOD isa FPLX 000437 SLRP_2 +HGNC 6724 LUM isa FPLX 000437 SLRP_2 +HGNC 9357 PRELP isa FPLX 000437 SLRP_2 +HGNC 6309 KERA isa FPLX 000437 SLRP_2 +HGNC 8134 OMD isa FPLX 000437 SLRP_2 +HGNC 3053 EPYC isa FPLX 000438 SLRP_3 +HGNC 8158 OPTC isa FPLX 000438 SLRP_3 +HGNC 8126 OGN isa FPLX 000438 SLRP_3 +HGNC 1909 CHAD isa FPLX 000439 SLRP_4 +HGNC 8082 NYX isa FPLX 000439 SLRP_4 +HGNC 28850 TSKU isa FPLX 000439 SLRP_4 +HGNC 23174 PODN isa FPLX 000440 SLRP_5 +HGNC 26275 PODNL1 isa FPLX 000440 SLRP_5 +FPLX 000436 SLRP_1 isa FPLX 000435 SLRP +FPLX 000437 SLRP_2 isa FPLX 000435 SLRP +FPLX 000438 SLRP_3 isa FPLX 000435 SLRP +FPLX 000439 SLRP_4 isa FPLX 000435 SLRP +FPLX 000440 SLRP_5 isa FPLX 000435 SLRP +HGNC 8986 PIM1 isa FPLX 000362 PIM +HGNC 8987 PIM2 isa FPLX 000362 PIM +HGNC 19310 PIM3 isa FPLX 000362 PIM +HGNC 4579 GRIK1 isa FPLX 000269 Kainate_family +HGNC 4580 GRIK2 isa FPLX 000269 Kainate_family +HGNC 4581 GRIK3 isa FPLX 000269 Kainate_family +HGNC 4582 GRIK4 isa FPLX 000269 Kainate_family +HGNC 4583 GRIK5 isa FPLX 000269 Kainate_family +HGNC 8008 NRXN1 isa FPLX 000308 Neurexins +HGNC 8009 NRXN2 isa FPLX 000308 Neurexins +HGNC 8010 NRXN3 isa FPLX 000308 Neurexins +HGNC 6008 IL2RA partof FPLX 000255 IL2R +HGNC 6009 IL2RB partof FPLX 000255 IL2R +HGNC 6010 IL2RG partof FPLX 000255 IL2R +HGNC 5978 IL15RA partof FPLX 000254 IL15R +HGNC 6009 IL2RB partof FPLX 000254 IL15R +HGNC 6010 IL2RG partof FPLX 000254 IL15R +HGNC 14275 MRPL1 partof FPLX 000290 MRPL +HGNC 14056 MRPL2 partof FPLX 000290 MRPL +HGNC 10379 MRPL3 partof FPLX 000290 MRPL +HGNC 14276 MRPL4 partof FPLX 000290 MRPL +HGNC 14277 MRPL9 partof FPLX 000290 MRPL +HGNC 14055 MRPL10 partof FPLX 000290 MRPL +HGNC 14042 MRPL11 partof FPLX 000290 MRPL +HGNC 10378 MRPL12 partof FPLX 000290 MRPL +HGNC 14278 MRPL13 partof FPLX 000290 MRPL +HGNC 14279 MRPL14 partof FPLX 000290 MRPL +HGNC 14054 MRPL15 partof FPLX 000290 MRPL +HGNC 14476 MRPL16 partof FPLX 000290 MRPL +HGNC 14053 MRPL17 partof FPLX 000290 MRPL +HGNC 14477 MRPL18 partof FPLX 000290 MRPL +HGNC 14052 MRPL19 partof FPLX 000290 MRPL +HGNC 14478 MRPL20 partof FPLX 000290 MRPL +HGNC 14479 MRPL21 partof FPLX 000290 MRPL +HGNC 14480 MRPL22 partof FPLX 000290 MRPL +HGNC 10322 MRPL23 partof FPLX 000290 MRPL +HGNC 14037 MRPL24 partof FPLX 000290 MRPL +HGNC 14483 MRPL27 partof FPLX 000290 MRPL +HGNC 14484 MRPL28 partof FPLX 000290 MRPL +HGNC 14036 MRPL30 partof FPLX 000290 MRPL +HGNC 14035 MRPL32 partof FPLX 000290 MRPL +HGNC 14487 MRPL33 partof FPLX 000290 MRPL +HGNC 14488 MRPL34 partof FPLX 000290 MRPL +HGNC 14489 MRPL35 partof FPLX 000290 MRPL +HGNC 14490 MRPL36 partof FPLX 000290 MRPL +HGNC 14034 MRPL37 partof FPLX 000290 MRPL +HGNC 14033 MRPL38 partof FPLX 000290 MRPL +HGNC 14027 MRPL39 partof FPLX 000290 MRPL +HGNC 14491 MRPL40 partof FPLX 000290 MRPL +HGNC 14492 MRPL41 partof FPLX 000290 MRPL +HGNC 14493 MRPL42 partof FPLX 000290 MRPL +HGNC 14517 MRPL43 partof FPLX 000290 MRPL +HGNC 16650 MRPL44 partof FPLX 000290 MRPL +HGNC 16651 MRPL45 partof FPLX 000290 MRPL +HGNC 1192 MRPL46 partof FPLX 000290 MRPL +HGNC 16652 MRPL47 partof FPLX 000290 MRPL +HGNC 16653 MRPL48 partof FPLX 000290 MRPL +HGNC 1176 MRPL49 partof FPLX 000290 MRPL +HGNC 16654 MRPL50 partof FPLX 000290 MRPL +HGNC 14044 MRPL51 partof FPLX 000290 MRPL +HGNC 16655 MRPL52 partof FPLX 000290 MRPL +HGNC 16684 MRPL53 partof FPLX 000290 MRPL +HGNC 16685 MRPL54 partof FPLX 000290 MRPL +HGNC 16686 MRPL55 partof FPLX 000290 MRPL +HGNC 14514 MRPL57 partof FPLX 000290 MRPL +HGNC 14495 MRPS2 partof FPLX 000289 MRPS +HGNC 14498 MRPS5 partof FPLX 000289 MRPS +HGNC 14051 MRPS6 partof FPLX 000289 MRPS +HGNC 14499 MRPS7 partof FPLX 000289 MRPS +HGNC 14501 MRPS9 partof FPLX 000289 MRPS +HGNC 14502 MRPS10 partof FPLX 000289 MRPS +HGNC 14050 MRPS11 partof FPLX 000289 MRPS +HGNC 10380 MRPS12 partof FPLX 000289 MRPS +HGNC 14049 MRPS14 partof FPLX 000289 MRPS +HGNC 14504 MRPS15 partof FPLX 000289 MRPS +HGNC 14048 MRPS16 partof FPLX 000289 MRPS +HGNC 14047 MRPS17 partof FPLX 000289 MRPS +HGNC 14515 MRPS18A partof FPLX 000289 MRPS +HGNC 14516 MRPS18B partof FPLX 000289 MRPS +HGNC 16633 MRPS18C partof FPLX 000289 MRPS +HGNC 14046 MRPS21 partof FPLX 000289 MRPS +HGNC 14508 MRPS22 partof FPLX 000289 MRPS +HGNC 14509 MRPS23 partof FPLX 000289 MRPS +HGNC 14510 MRPS24 partof FPLX 000289 MRPS +HGNC 14511 MRPS25 partof FPLX 000289 MRPS +HGNC 14045 MRPS26 partof FPLX 000289 MRPS +HGNC 14512 MRPS27 partof FPLX 000289 MRPS +HGNC 14513 MRPS28 partof FPLX 000289 MRPS +HGNC 2673 DAP3 partof FPLX 000289 MRPS +HGNC 8769 MRPS30 partof FPLX 000289 MRPS +HGNC 16632 MRPS31 partof FPLX 000289 MRPS +HGNC 16634 MRPS33 partof FPLX 000289 MRPS +HGNC 16618 MRPS34 partof FPLX 000289 MRPS +HGNC 16635 MRPS35 partof FPLX 000289 MRPS +HGNC 16631 MRPS36 partof FPLX 000289 MRPS +FPLX 000289 MRPS partof FPLX 000288 Mitochondrial_Ribosome +FPLX 000290 MRPL partof FPLX 000288 Mitochondrial_Ribosome +HGNC 7939 NPPA isa FPLX 000304 Natriuretic_peptide +HGNC 7940 NPPB isa FPLX 000304 Natriuretic_peptide +HGNC 7941 NPPC isa FPLX 000304 Natriuretic_peptide +HGNC 7455 MT-ND1 partof FPLX 000499 ETC_complex_I_core +HGNC 7456 MT-ND2 partof FPLX 000499 ETC_complex_I_core +HGNC 7458 MT-ND3 partof FPLX 000499 ETC_complex_I_core +HGNC 7459 MT-ND4 partof FPLX 000499 ETC_complex_I_core +HGNC 7460 MT-ND4L partof FPLX 000499 ETC_complex_I_core +HGNC 7461 MT-ND5 partof FPLX 000499 ETC_complex_I_core +HGNC 7462 MT-ND6 partof FPLX 000499 ETC_complex_I_core +HGNC 7707 NDUFS1 partof FPLX 000499 ETC_complex_I_core +HGNC 7708 NDUFS2 partof FPLX 000499 ETC_complex_I_core +HGNC 7710 NDUFS3 partof FPLX 000499 ETC_complex_I_core +HGNC 7714 NDUFS7 partof FPLX 000499 ETC_complex_I_core +HGNC 7715 NDUFS8 partof FPLX 000499 ETC_complex_I_core +HGNC 7716 NDUFV1 partof FPLX 000499 ETC_complex_I_core +HGNC 7717 NDUFV2 partof FPLX 000499 ETC_complex_I_core +HGNC 7694 NDUFAB1 partof FPLX 000500 ETC_complex_I_supernumerary +HGNC 7683 NDUFA1 partof FPLX 000500 ETC_complex_I_supernumerary +HGNC 7685 NDUFA2 partof FPLX 000500 ETC_complex_I_supernumerary +HGNC 7686 NDUFA3 partof FPLX 000500 ETC_complex_I_supernumerary +HGNC 7688 NDUFA5 partof FPLX 000500 ETC_complex_I_supernumerary +HGNC 7690 NDUFA6 partof FPLX 000500 ETC_complex_I_supernumerary +HGNC 7691 NDUFA7 partof FPLX 000500 ETC_complex_I_supernumerary +HGNC 7692 NDUFA8 partof FPLX 000500 ETC_complex_I_supernumerary +HGNC 7693 NDUFA9 partof FPLX 000500 ETC_complex_I_supernumerary +HGNC 7684 NDUFA10 partof FPLX 000500 ETC_complex_I_supernumerary +HGNC 20371 NDUFA11 partof FPLX 000500 ETC_complex_I_supernumerary +HGNC 23987 NDUFA12 partof FPLX 000500 ETC_complex_I_supernumerary +HGNC 17194 NDUFA13 partof FPLX 000500 ETC_complex_I_supernumerary +HGNC 7695 NDUFB1 partof FPLX 000500 ETC_complex_I_supernumerary +HGNC 7697 NDUFB2 partof FPLX 000500 ETC_complex_I_supernumerary +HGNC 7698 NDUFB3 partof FPLX 000500 ETC_complex_I_supernumerary +HGNC 7699 NDUFB4 partof FPLX 000500 ETC_complex_I_supernumerary +HGNC 7700 NDUFB5 partof FPLX 000500 ETC_complex_I_supernumerary +HGNC 7701 NDUFB6 partof FPLX 000500 ETC_complex_I_supernumerary +HGNC 7702 NDUFB7 partof FPLX 000500 ETC_complex_I_supernumerary +HGNC 7703 NDUFB8 partof FPLX 000500 ETC_complex_I_supernumerary +HGNC 7704 NDUFB9 partof FPLX 000500 ETC_complex_I_supernumerary +HGNC 7696 NDUFB10 partof FPLX 000500 ETC_complex_I_supernumerary +HGNC 20372 NDUFB11 partof FPLX 000500 ETC_complex_I_supernumerary +HGNC 7705 NDUFC1 partof FPLX 000500 ETC_complex_I_supernumerary +HGNC 7706 NDUFC2 partof FPLX 000500 ETC_complex_I_supernumerary +HGNC 7711 NDUFS4 partof FPLX 000500 ETC_complex_I_supernumerary +HGNC 7712 NDUFS5 partof FPLX 000500 ETC_complex_I_supernumerary +HGNC 7713 NDUFS6 partof FPLX 000500 ETC_complex_I_supernumerary +HGNC 7719 NDUFV3 partof FPLX 000500 ETC_complex_I_supernumerary +FPLX 000499 ETC_complex_I_core partof FPLX 000501 ETC_complex_I +FPLX 000500 ETC_complex_I_supernumerary partof FPLX 000501 ETC_complex_I +HGNC 10680 SDHA partof FPLX 000502 ETC_complex_II +HGNC 10681 SDHB partof FPLX 000502 ETC_complex_II +HGNC 10682 SDHC partof FPLX 000502 ETC_complex_II +HGNC 10683 SDHD partof FPLX 000502 ETC_complex_II +HGNC 2579 CYC1 partof FPLX 000503 ETC_complex_III +HGNC 7427 MT-CYB partof FPLX 000503 ETC_complex_III +HGNC 12582 UQCRB partof FPLX 000503 ETC_complex_III +HGNC 12585 UQCRC1 partof FPLX 000503 ETC_complex_III +HGNC 12586 UQCRC2 partof FPLX 000503 ETC_complex_III +HGNC 12587 UQCRFS1 partof FPLX 000503 ETC_complex_III +HGNC 12590 UQCRH partof FPLX 000503 ETC_complex_III +HGNC 29594 UQCRQ partof FPLX 000503 ETC_complex_III +HGNC 30863 UQCR10 partof FPLX 000503 ETC_complex_III +HGNC 30862 UQCR11 partof FPLX 000503 ETC_complex_III +HGNC 2265 COX4I1 partof FPLX 000504 ETC_complex_IV +HGNC 16232 COX4I2 partof FPLX 000504 ETC_complex_IV +HGNC 2267 COX5A partof FPLX 000504 ETC_complex_IV +HGNC 2269 COX5B partof FPLX 000504 ETC_complex_IV +HGNC 2277 COX6A1 partof FPLX 000504 ETC_complex_IV +HGNC 2279 COX6A2 partof FPLX 000504 ETC_complex_IV +HGNC 2280 COX6B1 partof FPLX 000504 ETC_complex_IV +HGNC 24380 COX6B2 partof FPLX 000504 ETC_complex_IV +HGNC 2285 COX6C partof FPLX 000504 ETC_complex_IV +HGNC 2287 COX7A1 partof FPLX 000504 ETC_complex_IV +HGNC 2288 COX7A2 partof FPLX 000504 ETC_complex_IV +HGNC 2291 COX7B partof FPLX 000504 ETC_complex_IV +HGNC 24381 COX7B2 partof FPLX 000504 ETC_complex_IV +HGNC 2292 COX7C partof FPLX 000504 ETC_complex_IV +HGNC 2294 COX8A partof FPLX 000504 ETC_complex_IV +HGNC 24382 COX8C partof FPLX 000504 ETC_complex_IV +HGNC 7419 MT-CO1 partof FPLX 000504 ETC_complex_IV +HGNC 7421 MT-CO2 partof FPLX 000504 ETC_complex_IV +HGNC 7422 MT-CO3 partof FPLX 000504 ETC_complex_IV +HGNC 823 ATP5F1A partof FPLX 000060 ATP_synthase +HGNC 830 ATP5F1B partof FPLX 000060 ATP_synthase +HGNC 833 ATP5F1C partof FPLX 000060 ATP_synthase +HGNC 837 ATP5F1D partof FPLX 000060 ATP_synthase +HGNC 838 ATP5F1E partof FPLX 000060 ATP_synthase +HGNC 30889 ATP5MD partof FPLX 000060 ATP_synthase +HGNC 846 ATP5ME partof FPLX 000060 ATP_synthase +HGNC 848 ATP5MF partof FPLX 000060 ATP_synthase +HGNC 14247 ATP5MG partof FPLX 000060 ATP_synthase +HGNC 1188 ATP5MPL partof FPLX 000060 ATP_synthase +HGNC 7414 MT-ATP6 partof FPLX 000060 ATP_synthase +HGNC 7415 MT-ATP8 partof FPLX 000060 ATP_synthase +HGNC 840 ATP5PB partof FPLX 000060 ATP_synthase +HGNC 845 ATP5PD partof FPLX 000060 ATP_synthase +HGNC 847 ATP5PF partof FPLX 000060 ATP_synthase +HGNC 850 ATP5PO partof FPLX 000060 ATP_synthase +HGNC 871 ATP5IF1 partof FPLX 000060 ATP_synthase +HGNC 841 ATP5MC1 isa FPLX 000059 ATP5G +HGNC 842 ATP5MC2 isa FPLX 000059 ATP5G +HGNC 843 ATP5MC3 isa FPLX 000059 ATP5G +FPLX 000059 ATP5G partof FPLX 000060 ATP_synthase +HGNC 7393 MT1A isa FPLX 000292 Metallothionein +HGNC 7394 MT1B isa FPLX 000292 Metallothionein +HGNC 7395 MT1CP isa FPLX 000292 Metallothionein +HGNC 7396 MT1DP isa FPLX 000292 Metallothionein +HGNC 7397 MT1E isa FPLX 000292 Metallothionein +HGNC 7398 MT1F isa FPLX 000292 Metallothionein +HGNC 7399 MT1G isa FPLX 000292 Metallothionein +HGNC 7400 MT1H isa FPLX 000292 Metallothionein +HGNC 31864 MT1HL1 isa FPLX 000292 Metallothionein +HGNC 7401 MT1IP isa FPLX 000292 Metallothionein +HGNC 7402 MT1JP isa FPLX 000292 Metallothionein +HGNC 7404 MT1L isa FPLX 000292 Metallothionein +HGNC 14296 MT1M isa FPLX 000292 Metallothionein +HGNC 23681 MT1P1 isa FPLX 000292 Metallothionein +HGNC 16120 MT1P3 isa FPLX 000292 Metallothionein +HGNC 7405 MT1X isa FPLX 000292 Metallothionein +HGNC 7406 MT2A isa FPLX 000292 Metallothionein +HGNC 7408 MT3 isa FPLX 000292 Metallothionein +HGNC 18705 MT4 isa FPLX 000292 Metallothionein +HGNC 660 TRIM23 isa FPLX 000053 ARF_GTPase_family +HGNC 652 ARF1 isa FPLX 000053 ARF_GTPase_family +HGNC 654 ARF3 isa FPLX 000053 ARF_GTPase_family +HGNC 655 ARF4 isa FPLX 000053 ARF_GTPase_family +HGNC 658 ARF5 isa FPLX 000053 ARF_GTPase_family +HGNC 659 ARF6 isa FPLX 000053 ARF_GTPase_family +HGNC 692 ARL1 isa FPLX 000053 ARF_GTPase_family +HGNC 693 ARL2 isa FPLX 000053 ARF_GTPase_family +HGNC 694 ARL3 isa FPLX 000053 ARF_GTPase_family +HGNC 695 ARL4A isa FPLX 000053 ARF_GTPase_family +HGNC 698 ARL4C isa FPLX 000053 ARF_GTPase_family +HGNC 656 ARL4D isa FPLX 000053 ARF_GTPase_family +HGNC 696 ARL5A isa FPLX 000053 ARF_GTPase_family +HGNC 23052 ARL5B isa FPLX 000053 ARF_GTPase_family +HGNC 31111 ARL5C isa FPLX 000053 ARF_GTPase_family +HGNC 13210 ARL6 isa FPLX 000053 ARF_GTPase_family +HGNC 25192 ARL8A isa FPLX 000053 ARF_GTPase_family +HGNC 25564 ARL8B isa FPLX 000053 ARF_GTPase_family +HGNC 23592 ARL9 isa FPLX 000053 ARF_GTPase_family +HGNC 22042 ARL10 isa FPLX 000053 ARF_GTPase_family +HGNC 24046 ARL11 isa FPLX 000053 ARF_GTPase_family +HGNC 31709 ARL13A isa FPLX 000053 ARF_GTPase_family +HGNC 25419 ARL13B isa FPLX 000053 ARF_GTPase_family +HGNC 22974 ARL14 isa FPLX 000053 ARF_GTPase_family +HGNC 25945 ARL15 isa FPLX 000053 ARF_GTPase_family +HGNC 27902 ARL16 isa FPLX 000053 ARF_GTPase_family +HGNC 24096 ARL17A isa FPLX 000053 ARF_GTPase_family +HGNC 32387 ARL17B isa FPLX 000053 ARF_GTPase_family +HGNC 662 ARFRP1 isa FPLX 000053 ARF_GTPase_family +HGNC 10534 SAR1A isa FPLX 000053 ARF_GTPase_family +HGNC 10535 SAR1B isa FPLX 000053 ARF_GTPase_family +FPLX 000002 A4GALT_family isa FPLX 000198 Glycosyltransferase +FPLX 000026 ALG10 isa FPLX 000198 Glycosyltransferase +FPLX 000027 ALG1_family isa FPLX 000198 Glycosyltransferase +FPLX 000028 ALG3_family isa FPLX 000198 Glycosyltransferase +FPLX 000029 ALG6_family isa FPLX 000198 Glycosyltransferase +FPLX 000030 ALG13_family isa FPLX 000198 Glycosyltransferase +FPLX 000063 B3GAT isa FPLX 000198 Glycosyltransferase +FPLX 000065 Beta_3_4_GTF isa FPLX 000198 Glycosyltransferase +FPLX 000112 COLGALT isa FPLX 000198 Glycosyltransferase +FPLX 000165 EXT isa FPLX 000198 Glycosyltransferase +FPLX 000176 FUT isa FPLX 000198 Glycosyltransferase +FPLX 000180 GALNT isa FPLX 000198 Glycosyltransferase +FPLX 000185 GCNT isa FPLX 000198 Glycosyltransferase +FPLX 000199 GTF_family_2 isa FPLX 000198 Glycosyltransferase +FPLX 000200 GTF_family_6 isa FPLX 000198 Glycosyltransferase +FPLX 000201 GTF_family_8 isa FPLX 000198 Glycosyltransferase +FPLX 000202 GTF_family_29 isa FPLX 000198 Glycosyltransferase +FPLX 000203 GTF_family_90 isa FPLX 000198 Glycosyltransferase +FPLX 000287 MGAT isa FPLX 000198 Glycosyltransferase +FPLX 000322 OGT_family isa FPLX 000198 Glycosyltransferase +FPLX 000396 PYG isa FPLX 000198 Glycosyltransferase +FPLX 000455 STT3 isa FPLX 000198 Glycosyltransferase +FPLX 000491 UGCG isa FPLX 000198 Glycosyltransferase +FPLX 000492 UGT isa FPLX 000198 Glycosyltransferase +FPLX 000493 UGGT isa FPLX 000198 Glycosyltransferase +HGNC 23162 ALG10 isa FPLX 000026 ALG10 +HGNC 31088 ALG10B isa FPLX 000026 ALG10 +HGNC 23157 ALG6 isa FPLX 000029 ALG6_family +HGNC 23161 ALG8 isa FPLX 000029 ALG6_family +HGNC 18149 A4GALT isa FPLX 000002 A4GALT_family +HGNC 17968 A4GNT isa FPLX 000002 A4GALT_family +HGNC 921 B3GAT1 isa FPLX 000063 B3GAT +HGNC 922 B3GAT2 isa FPLX 000063 B3GAT +HGNC 923 B3GAT3 isa FPLX 000063 B3GAT +HGNC 918 B3GALNT1 isa FPLX 000065 Beta_3_4_GTF +HGNC 28596 B3GALNT2 isa FPLX 000065 Beta_3_4_GTF +HGNC 20207 B3GLCT isa FPLX 000065 Beta_3_4_GTF +HGNC 916 B3GALT1 isa FPLX 000065 Beta_3_4_GTF +HGNC 917 B3GALT2 isa FPLX 000065 Beta_3_4_GTF +HGNC 919 B3GALT4 isa FPLX 000065 Beta_3_4_GTF +HGNC 920 B3GALT5 isa FPLX 000065 Beta_3_4_GTF +HGNC 17978 B3GALT6 isa FPLX 000065 Beta_3_4_GTF +HGNC 15629 B3GNT2 isa FPLX 000065 Beta_3_4_GTF +HGNC 13528 B3GNT3 isa FPLX 000065 Beta_3_4_GTF +HGNC 15683 B3GNT4 isa FPLX 000065 Beta_3_4_GTF +HGNC 15684 B3GNT5 isa FPLX 000065 Beta_3_4_GTF +HGNC 24141 B3GNT6 isa FPLX 000065 Beta_3_4_GTF +HGNC 18811 B3GNT7 isa FPLX 000065 Beta_3_4_GTF +HGNC 24139 B3GNT8 isa FPLX 000065 Beta_3_4_GTF +HGNC 28714 B3GNT9 isa FPLX 000065 Beta_3_4_GTF +HGNC 24291 CHPF isa FPLX 000065 Beta_3_4_GTF +HGNC 29270 CHPF2 isa FPLX 000065 Beta_3_4_GTF +HGNC 17198 CHSY1 isa FPLX 000065 Beta_3_4_GTF +HGNC 24293 CHSY3 isa FPLX 000065 Beta_3_4_GTF +HGNC 24337 C1GALT1 isa FPLX 000065 Beta_3_4_GTF +HGNC 6560 LFNG isa FPLX 000065 Beta_3_4_GTF +HGNC 7038 MFNG isa FPLX 000065 Beta_3_4_GTF +HGNC 9974 RFNG isa FPLX 000065 Beta_3_4_GTF +HGNC 4117 B4GALNT1 isa FPLX 000065 Beta_3_4_GTF +HGNC 24136 B4GALNT2 isa FPLX 000065 Beta_3_4_GTF +HGNC 24137 B4GALNT3 isa FPLX 000065 Beta_3_4_GTF +HGNC 26315 B4GALNT4 isa FPLX 000065 Beta_3_4_GTF +HGNC 924 B4GALT1 isa FPLX 000065 Beta_3_4_GTF +HGNC 925 B4GALT2 isa FPLX 000065 Beta_3_4_GTF +HGNC 926 B4GALT3 isa FPLX 000065 Beta_3_4_GTF +HGNC 927 B4GALT4 isa FPLX 000065 Beta_3_4_GTF +HGNC 928 B4GALT5 isa FPLX 000065 Beta_3_4_GTF +HGNC 929 B4GALT6 isa FPLX 000065 Beta_3_4_GTF +HGNC 930 B4GALT7 isa FPLX 000065 Beta_3_4_GTF +HGNC 24290 CSGALNACT1 isa FPLX 000065 Beta_3_4_GTF +HGNC 24292 CSGALNACT2 isa FPLX 000065 Beta_3_4_GTF +HGNC 26182 COLGALT1 isa FPLX 000112 COLGALT +HGNC 16790 COLGALT2 isa FPLX 000112 COLGALT +HGNC 23056 ALG3 isa FPLX 000028 ALG3_family +HGNC 15672 ALG9 isa FPLX 000028 ALG3_family +HGNC 19358 ALG12 isa FPLX 000028 ALG3_family +HGNC 8959 PIGB isa FPLX 000028 ALG3_family +HGNC 18858 PIGM isa FPLX 000028 ALG3_family +HGNC 26031 PIGV isa FPLX 000028 ALG3_family +HGNC 30596 PIGZ isa FPLX 000028 ALG3_family +HGNC 9202 POMT1 isa FPLX 000028 ALG3_family +HGNC 19743 POMT2 isa FPLX 000028 ALG3_family +HGNC 3515 EXTL1 isa FPLX 000165 EXT +HGNC 3516 EXTL2 isa FPLX 000165 EXT +HGNC 3518 EXTL3 isa FPLX 000165 EXT +HGNC 3512 EXT1 isa FPLX 000165 EXT +HGNC 3513 EXT2 isa FPLX 000165 EXT +HGNC 4012 FUT1 isa FPLX 000176 FUT +HGNC 4013 FUT2 isa FPLX 000176 FUT +HGNC 4014 FUT3 isa FPLX 000176 FUT +HGNC 4015 FUT4 isa FPLX 000176 FUT +HGNC 4016 FUT5 isa FPLX 000176 FUT +HGNC 4017 FUT6 isa FPLX 000176 FUT +HGNC 4018 FUT7 isa FPLX 000176 FUT +HGNC 4019 FUT8 isa FPLX 000176 FUT +HGNC 4020 FUT9 isa FPLX 000176 FUT +HGNC 19234 FUT10 isa FPLX 000176 FUT +HGNC 19233 FUT11 isa FPLX 000176 FUT +HGNC 14988 POFUT1 isa FPLX 000176 FUT +HGNC 14683 POFUT2 isa FPLX 000176 FUT +HGNC 4203 GCNT1 isa FPLX 000185 GCNT +HGNC 4204 GCNT2 isa FPLX 000185 GCNT +HGNC 4205 GCNT3 isa FPLX 000185 GCNT +HGNC 17973 GCNT4 isa FPLX 000185 GCNT +HGNC 16099 GCNT7 isa FPLX 000185 GCNT +HGNC 15516 XYLT1 isa FPLX 000185 GCNT +HGNC 15517 XYLT2 isa FPLX 000185 GCNT +HGNC 9723 PYGB isa FPLX 000396 PYG +HGNC 9725 PYGL isa FPLX 000396 PYG +HGNC 9726 PYGM isa FPLX 000396 PYG +HGNC 20266 ALG5 isa FPLX 000199 GTF_family_2 +HGNC 21727 B3GNTL1 isa FPLX 000199 GTF_family_2 +HGNC 3005 DPM1 isa FPLX 000199 GTF_family_2 +HGNC 4818 HAS1 isa FPLX 000199 GTF_family_2 +HGNC 4819 HAS2 isa FPLX 000199 GTF_family_2 +HGNC 4820 HAS3 isa FPLX 000199 GTF_family_2 +HGNC 79 ABO isa FPLX 000200 GTF_family_6 +HGNC 30005 A3GALT2 isa FPLX 000200 GTF_family_6 +HGNC 20460 GBGT1 isa FPLX 000200 GTF_family_6 +HGNC 23671 GLT6D1 isa FPLX 000200 GTF_family_6 +HGNC 24870 GLT8D1 isa FPLX 000201 GTF_family_8 +HGNC 24890 GLT8D2 isa FPLX 000201 GTF_family_8 +HGNC 27482 GXYLT1 isa FPLX 000201 GTF_family_8 +HGNC 33383 GXYLT2 isa FPLX 000201 GTF_family_8 +HGNC 4699 GYG1 isa FPLX 000201 GTF_family_8 +HGNC 4700 GYG2 isa FPLX 000201 GTF_family_8 +HGNC 6511 LARGE1 isa FPLX 000201 GTF_family_8 +HGNC 16522 LARGE2 isa FPLX 000201 GTF_family_8 +HGNC 13530 RXYLT1 isa FPLX 000201 GTF_family_8 +HGNC 26639 XXYLT1 isa FPLX 000201 GTF_family_8 +HGNC 19350 POGLUT2 isa FPLX 000203 GTF_family_90 +HGNC 28496 POGLUT3 isa FPLX 000203 GTF_family_90 +HGNC 22954 POGLUT1 isa FPLX 000203 GTF_family_90 +HGNC 18294 ALG1 isa FPLX 000027 ALG1_family +HGNC 33721 ALG1L isa FPLX 000027 ALG1_family +HGNC 37258 ALG1L2 isa FPLX 000027 ALG1_family +HGNC 23159 ALG2 isa FPLX 000027 ALG1_family +HGNC 32456 ALG11 isa FPLX 000027 ALG1_family +HGNC 26483 GLT1D1 isa FPLX 000027 ALG1_family +HGNC 20887 GTDC1 isa FPLX 000027 ALG1_family +HGNC 4706 GYS1 isa FPLX 000027 ALG1_family +HGNC 4707 GYS2 isa FPLX 000027 ALG1_family +HGNC 8957 PIGA isa FPLX 000027 ALG1_family +HGNC 7044 MGAT1 isa FPLX 000287 MGAT +HGNC 7045 MGAT2 isa FPLX 000287 MGAT +HGNC 7046 MGAT3 isa FPLX 000287 MGAT +HGNC 7047 MGAT4A isa FPLX 000287 MGAT +HGNC 7048 MGAT4B isa FPLX 000287 MGAT +HGNC 30871 MGAT4C isa FPLX 000287 MGAT +HGNC 43619 MGAT4D isa FPLX 000287 MGAT +HGNC 7049 MGAT5 isa FPLX 000287 MGAT +HGNC 24140 MGAT5B isa FPLX 000287 MGAT +HGNC 28526 EOGT isa FPLX 000322 OGT_family +HGNC 8127 OGT isa FPLX 000322 OGT_family +HGNC 19139 POMGNT1 isa FPLX 000322 OGT_family +HGNC 25902 POMGNT2 isa FPLX 000322 OGT_family +HGNC 21725 GALNTL5 isa FPLX 000180 GALNT +HGNC 33844 GALNTL6 isa FPLX 000180 GALNT +HGNC 4123 GALNT1 isa FPLX 000180 GALNT +HGNC 4124 GALNT2 isa FPLX 000180 GALNT +HGNC 4125 GALNT3 isa FPLX 000180 GALNT +HGNC 4126 GALNT4 isa FPLX 000180 GALNT +HGNC 4127 GALNT5 isa FPLX 000180 GALNT +HGNC 4128 GALNT6 isa FPLX 000180 GALNT +HGNC 4129 GALNT7 isa FPLX 000180 GALNT +HGNC 4130 GALNT8 isa FPLX 000180 GALNT +HGNC 4131 GALNT9 isa FPLX 000180 GALNT +HGNC 19873 GALNT10 isa FPLX 000180 GALNT +HGNC 19875 GALNT11 isa FPLX 000180 GALNT +HGNC 19877 GALNT12 isa FPLX 000180 GALNT +HGNC 23242 GALNT13 isa FPLX 000180 GALNT +HGNC 22946 GALNT14 isa FPLX 000180 GALNT +HGNC 21531 GALNT15 isa FPLX 000180 GALNT +HGNC 23233 GALNT16 isa FPLX 000180 GALNT +HGNC 30488 GALNT18 isa FPLX 000180 GALNT +HGNC 16347 GALNT17 isa FPLX 000180 GALNT +HGNC 10862 ST3GAL1 isa FPLX 000202 GTF_family_29 +HGNC 10863 ST3GAL2 isa FPLX 000202 GTF_family_29 +HGNC 10866 ST3GAL3 isa FPLX 000202 GTF_family_29 +HGNC 10864 ST3GAL4 isa FPLX 000202 GTF_family_29 +HGNC 10872 ST3GAL5 isa FPLX 000202 GTF_family_29 +HGNC 18080 ST3GAL6 isa FPLX 000202 GTF_family_29 +HGNC 23614 ST6GALNAC1 isa FPLX 000202 GTF_family_29 +HGNC 10867 ST6GALNAC2 isa FPLX 000202 GTF_family_29 +HGNC 19343 ST6GALNAC3 isa FPLX 000202 GTF_family_29 +HGNC 17846 ST6GALNAC4 isa FPLX 000202 GTF_family_29 +HGNC 19342 ST6GALNAC5 isa FPLX 000202 GTF_family_29 +HGNC 23364 ST6GALNAC6 isa FPLX 000202 GTF_family_29 +HGNC 10860 ST6GAL1 isa FPLX 000202 GTF_family_29 +HGNC 10861 ST6GAL2 isa FPLX 000202 GTF_family_29 +HGNC 10869 ST8SIA1 isa FPLX 000202 GTF_family_29 +HGNC 10870 ST8SIA2 isa FPLX 000202 GTF_family_29 +HGNC 14269 ST8SIA3 isa FPLX 000202 GTF_family_29 +HGNC 10871 ST8SIA4 isa FPLX 000202 GTF_family_29 +HGNC 17827 ST8SIA5 isa FPLX 000202 GTF_family_29 +HGNC 23317 ST8SIA6 isa FPLX 000202 GTF_family_29 +HGNC 6172 STT3A isa FPLX 000455 STT3 +HGNC 30611 STT3B isa FPLX 000455 STT3 +HGNC 12524 UGCG isa FPLX 000491 UGCG +HGNC 15663 UGGT1 isa FPLX 000493 UGGT +HGNC 15664 UGGT2 isa FPLX 000493 UGGT +HGNC 12529 UGT1A isa FPLX 000492 UGT +HGNC 12530 UGT1A1 isa FPLX 000492 UGT +HGNC 12534 UGT1A2P isa FPLX 000492 UGT +HGNC 12535 UGT1A3 isa FPLX 000492 UGT +HGNC 12536 UGT1A4 isa FPLX 000492 UGT +HGNC 12537 UGT1A5 isa FPLX 000492 UGT +HGNC 12538 UGT1A6 isa FPLX 000492 UGT +HGNC 12539 UGT1A7 isa FPLX 000492 UGT +HGNC 12540 UGT1A8 isa FPLX 000492 UGT +HGNC 12541 UGT1A9 isa FPLX 000492 UGT +HGNC 12531 UGT1A10 isa FPLX 000492 UGT +HGNC 12532 UGT1A11P isa FPLX 000492 UGT +HGNC 12533 UGT1A12P isa FPLX 000492 UGT +HGNC 32191 UGT1A13P isa FPLX 000492 UGT +HGNC 12542 UGT2A1 isa FPLX 000492 UGT +HGNC 28183 UGT2A2 isa FPLX 000492 UGT +HGNC 28528 UGT2A3 isa FPLX 000492 UGT +HGNC 12553 UGT2B4 isa FPLX 000492 UGT +HGNC 12554 UGT2B7 isa FPLX 000492 UGT +HGNC 12544 UGT2B10 isa FPLX 000492 UGT +HGNC 12545 UGT2B11 isa FPLX 000492 UGT +HGNC 12546 UGT2B15 isa FPLX 000492 UGT +HGNC 12547 UGT2B17 isa FPLX 000492 UGT +HGNC 12548 UGT2B24P isa FPLX 000492 UGT +HGNC 12549 UGT2B25P isa FPLX 000492 UGT +HGNC 12550 UGT2B26P isa FPLX 000492 UGT +HGNC 12551 UGT2B27P isa FPLX 000492 UGT +HGNC 13479 UGT2B28 isa FPLX 000492 UGT +HGNC 12552 UGT2B29P isa FPLX 000492 UGT +HGNC 26625 UGT3A1 isa FPLX 000492 UGT +HGNC 27266 UGT3A2 isa FPLX 000492 UGT +HGNC 12555 UGT8 isa FPLX 000492 UGT +HGNC 30881 ALG13 isa FPLX 000030 ALG13_family +HGNC 28287 ALG14 isa FPLX 000030 ALG13_family +HGNC 9855 RAP1A isa FPLX 000401 RAP1 +HGNC 9857 RAP1B isa FPLX 000401 RAP1 +HGNC 11142 SIK1 isa FPLX 000433 SIK +HGNC 21680 SIK2 isa FPLX 000433 SIK +HGNC 29165 SIK3 isa FPLX 000433 SIK +HGNC 3091 DYRK1A isa FPLX 000146 DYRK +HGNC 3092 DYRK1B isa FPLX 000146 DYRK +HGNC 3093 DYRK2 isa FPLX 000146 DYRK +HGNC 3094 DYRK3 isa FPLX 000146 DYRK +HGNC 3095 DYRK4 isa FPLX 000146 DYRK +HGNC 25174 HAUS1 partof FPLX 000061 Augmin +HGNC 25530 HAUS2 partof FPLX 000061 Augmin +HGNC 28719 HAUS3 partof FPLX 000061 Augmin +HGNC 20163 HAUS4 partof FPLX 000061 Augmin +HGNC 29130 HAUS5 partof FPLX 000061 Augmin +HGNC 25948 HAUS6 partof FPLX 000061 Augmin +HGNC 32979 HAUS7 partof FPLX 000061 Augmin +HGNC 30532 HAUS8 partof FPLX 000061 Augmin +HGNC 16062 CRTC1 isa FPLX 000123 CRTC +HGNC 27301 CRTC2 isa FPLX 000123 CRTC +HGNC 26148 CRTC3 isa FPLX 000123 CRTC diff --git a/famplex/resources/relations_graph.pdf b/famplex/resources/relations_graph.pdf new file mode 100644 index 0000000000000000000000000000000000000000..67ecc0792558df6c4055e3a3e0c1cc11244cee7f GIT binary patch literal 647384 zcmV)bK&ihaP((&8F)lL-CB)_O4?5av(28Y+-a|L}g=dWMv>eJ_>Vma%Ev{3U~p`z1fm$$#tfAkEa0dA}>0G 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That's why we test! --- .../check_references.py | 204 +- famplex/reorganize_old_resources.py | 11 +- famplex/resources/grounding_map.tsv | 1920 ++++++++--------- famplex/resources/metadata.json | 2 +- famplex/resources/relations.tsv | 18 +- 5 files changed, 1072 insertions(+), 1083 deletions(-) rename check_references.py => famplex/check_references.py (63%) diff --git a/check_references.py b/famplex/check_references.py similarity index 63% rename from check_references.py rename to famplex/check_references.py index 93d80912d..81745e513 100644 --- a/check_references.py +++ b/famplex/check_references.py @@ -1,92 +1,64 @@ -from __future__ import print_function, unicode_literals +# -*- coding: utf-8 -*- + +"""Check the validity and integrity of the FamPlex resources.""" + import csv import sys -from collections import Counter +from collections import Counter, defaultdict - -def read_csv(fh, delimiter, quotechar): - if sys.version_info.major < 3: - csvreader = csv.reader(fh, delimiter=bytes(delimiter), - quotechar=bytes(quotechar)) - rows = [[cell.decode('utf-8') for cell in row] for row in csvreader] - else: - csvreader = csv.reader(fh, delimiter=delimiter, quotechar=quotechar) - rows = [row for row in csvreader] - return rows +from famplex.constants import ENTITIES_TSV_PATH, EQUIVALENCES_TSV_PATH, GROUNDING_MAP_TSV_PATH, RELATIONS_TSV_PATH -def load_csv(filename): - with open(filename) as f: - rows = read_csv(f, ',', '"') - return rows +def load_tsv(path): + """Load the rows of a TSV file.""" + with open(path) as fh: + return tuple(tuple(row) for row in csv.reader(fh, delimiter='\t')) def load_grounding_map(filename): - gm_rows = load_csv(filename) - gm_tuples = [] - check_rows(gm_rows, 7, filename) - g_map = {} - for row in gm_rows: - gm_tuples.append(tuple(row)) - key = row[0] - db_refs = {'TEXT': key} - keys = [entry for entry in row[1::2] if entry != ''] - values = [entry for entry in row[2::2] if entry != ''] - if len(keys) != len(values): - print('ERROR: Mismatched keys and values in row %s' % str(row)) - continue - else: - db_refs.update(dict(zip(keys, values))) - if len(db_refs.keys()) > 1: - g_map[key] = db_refs - else: - g_map[key] = None - return g_map, tuple(gm_tuples) + gm_rows = load_tsv(filename) + check_rows(gm_rows, 4, filename) + g_map = defaultdict(dict) + for text, db, db_id, _ in gm_rows: + g_map[text][db] = db_id + return g_map, gm_rows def check_file_rows(filename, row_length): - with open(filename) as f: - rows = read_csv(f, ',', '"') + rows = load_tsv(filename) check_rows(rows, row_length, filename) def check_rows(rows, row_length, filename): - for ix, row in enumerate(rows): + for ix, row in enumerate(rows, start=1): if len(row) != row_length: print("ERROR: Line %d in file %s has %d columns, should be %d" % - ((ix + 1), filename, len(row), row_length)) + (ix, filename, len(row), row_length)) def load_entity_list(filename): - with open(filename) as f: - rows = read_csv(f, ',', '"') - check_rows(rows, 1, filename) - entities = [row[0] for row in rows] - return entities + rows = load_tsv(filename) + check_rows(rows, 4, filename) + return rows def load_relationships(filename): - relationships = [] - with open(filename) as f: - rows = read_csv(f, ',', '"') - check_rows(rows, 5, filename) - for row in rows: - relationships.append(((row[0], row[1]), row[2], (row[3], row[4]))) - return relationships + rows = load_tsv(filename) + check_rows(rows, 7, filename) + return [ + ((sns, sid, sname), rel, (ons, oid, oname)) + for sns, sid, sname, rel, ons, oid, oname in rows + ] def load_equivalences(filename): - equivalences = [] - with open(filename) as f: - rows = read_csv(f, ',', '"') - check_rows(rows, 3, filename) - for row in rows: - equivalences.append((row[0], row[1], row[2])) - return equivalences + rows = load_tsv(filename) + check_rows(rows, 4, filename) + return rows def update_id_prefixes(filename): - gm_rows = load_csv(filename) + gm_rows = load_tsv(filename) updated_rows = [] for row in gm_rows: key = row[0] @@ -130,13 +102,17 @@ def check_duplicates(entries, entry_label): return found_duplicates -if __name__ == '__main__': +def main(): signal_error = False - entities = load_entity_list('entities.csv') - relationships = load_relationships('relations.csv') - equivalences = load_equivalences('equivalences.csv') - gm, gm_tuples = load_grounding_map('grounding_map.csv') - check_file_rows('gene_prefixes.csv', 3) + entities = load_entity_list(ENTITIES_TSV_PATH) + relationships = load_relationships(RELATIONS_TSV_PATH) + equivalences = load_equivalences(EQUIVALENCES_TSV_PATH) + gm, gm_tuples = load_grounding_map(GROUNDING_MAP_TSV_PATH) + + em = { + eid: ename + for eid, ename, *_ in entities + } for entries, entry_label in ((entities, 'entities'), (relationships, 'relationships'), @@ -149,13 +125,12 @@ def check_duplicates(entries, entry_label): # Look through grounding map and find all instances with an FPLX db key entities_missing_gm = [] for text, db_refs in gm.items(): - if db_refs is not None: - for db_key, db_id in db_refs.items(): - if db_key == 'FPLX' and db_id not in entities: - entities_missing_gm.append(db_id) - print("ERROR: ID %s referenced in grounding map " - "is not in entities list." % db_id) - signal_error = True + for db_key, db_id in db_refs.items(): + if db_key == 'FPLX' and db_id not in em: + entities_missing_gm.append(db_id) + print("ERROR: ID %s referenced in grounding map " + "is not in entities list." % db_id) + signal_error = True print() print("-- Checking for CHEBI/PUBCHEM IDs--") @@ -166,11 +141,11 @@ def check_duplicates(entries, entry_label): p_and_c = pubchem_and_chebi(db_refs) if p_and_c == 'chebi_missing': chebi_id_missing.append(db_refs['PUBCHEM']) - print("WARNING: %s has PUBCHEM ID (%s) but no CHEBI ID." + print("WARNING: %s has PubChem ID (pubchem.compound:%s) but no CHEBI ID." % (text, db_refs['PUBCHEM'])) if p_and_c == 'pubchem_missing': pubchem_id_missing.append(db_refs['CHEBI']) - print("WARNING: %s has CHEBI ID (%s) but no PUBCHEM ID." % + print("WARNING: %s has ChEBI ID (%s) but no PUBCHEM ID." % (text, db_refs['CHEBI'])) print() @@ -179,39 +154,39 @@ def check_duplicates(entries, entry_label): # Check the relationships for consistency with entities entities_missing_rel = [] for subj, rel, obj in relationships: - for term in (subj, obj): - term_ns = term[0] - term_id = term[1] - if term_ns == 'FPLX' and term_id not in entities: + for term_ns, term_id, term_name in (subj, obj): + if term_ns == 'FPLX' and term_id not in em: entities_missing_rel.append(term_id) print("ERROR: ID %s referenced in relations " "is not in entities list." % term_id) signal_error = True print() print("-- Checking for valid namespaces in relations --") - for ix, (subj, rel, obj) in enumerate(relationships): - for term in (subj, obj): - term_ns = term[0] + for ix, (subj, rel, obj) in enumerate(relationships, start=1): + for term_ns, term_id, term_name in (subj, obj): if term_ns not in ('FPLX', 'HGNC', 'UP'): print("ERROR: row %d: Invalid namespace in relations.csv: %s" % - (ix+1, term_ns)) + (ix, term_ns)) signal_error = True # This check requires the indra package try: from indra.databases import hgnc_client + print() print("-- Checking for invalid HGNC IDs in relationships file --") for subj, rel, obj in relationships: - for term in (subj, obj): - term_ns = term[0] - term_id = term[1] + for term_ns, term_id, term_name in (subj, obj): if term_ns == 'HGNC': - hgnc_id = hgnc_client.get_hgnc_id(term_id) - if not hgnc_id: + lu_term_name = hgnc_client.get_hgnc_name(term_id) + if not lu_term_name: print("ERROR: ID %s referenced in relations is " "not a valid HGNC ID." % term_id) signal_error = True + if term_name != lu_term_name: + print("ERROR: HGNC %s symbol out of sync." + "%s should be %s" % term_id, term_name, lu_term_name) + signal_error = True except ImportError as e: print('HGNC check could not be performed because of import error') print(e) @@ -221,16 +196,17 @@ def check_duplicates(entries, entry_label): # This check requires the indra package try: from indra.databases import hgnc_client + print() print("-- Checking for invalid HGNC IDs in grounding map --") for text, db_refs in gm.items(): if db_refs is not None: for db_key, db_id in db_refs.items(): if db_key == 'HGNC': - hgnc_id = hgnc_client.get_hgnc_id(db_id) - if not hgnc_id: + lu_term_name = hgnc_client.get_hgnc_name(db_id) + if not lu_term_name: print("ERROR: ID %s in grounding map is " - "not a valid HGNC ID." % db_id) + "not a valid HGNC ID." % db_id) signal_error = True except ImportError: print('HGNC check could not be performed because of import error') @@ -260,13 +236,9 @@ def check_duplicates(entries, entry_label): print("-- Checking for FamPlexes whose relationships are undefined --") # Check the relationships for consistency with entities rel_missing_entities = [] - for ent in entities: + for ent in em: found = False - for subj, rel, obj in relationships: - subj_ns = subj[0] - subj_id = subj[1] - obj_ns = obj[0] - obj_id = obj[1] + for (subj_ns, subj_id, _), rel, (obj_ns, obj_id, _) in relationships: if subj_ns == 'FPLX' and subj_id == ent: found = True break @@ -280,12 +252,12 @@ def check_duplicates(entries, entry_label): print() print("-- Checking for non-existent FamPlexes in equivalences --") entities_missing_eq = [] - for eq_ns, eq_id, be_id in equivalences: - if be_id not in entities: + for eq_ns, eq_id, fplx_id, _ in equivalences: + if fplx_id not in em: signal_error = True - entities_missing_eq.append(be_id) + entities_missing_eq.append(fplx_id) print("ERROR: ID %s referenced in equivalences " - "is not in entities list." % be_id) + "is not in entities list." % fplx_id) print() print("-- Checking for duplicate equivalences --") equiv_counter = Counter(equivalences) @@ -300,23 +272,33 @@ def check_duplicates(entries, entry_label): try: import requests import logging + from tqdm import tqdm + except ImportError: + pass + else: logging.getLogger('requests').setLevel(logging.CRITICAL) logging.getLogger('urllib3').setLevel(logging.CRITICAL) print() print("-- Checking for invalid PUBCHEM CIDs in grounding map --") pubchem_url = 'https://pubchem.ncbi.nlm.nih.gov/rest/pug/compound/' + \ 'cid/%s/description/XML' - for text, db_refs in gm.items(): - if db_refs is not None: - for db_key, db_id in db_refs.items(): - if db_key == 'PUBCHEM': - res = requests.get(pubchem_url % db_id) - if res.status_code != 200: - print("ERROR: ID %s in grounding map is " - "not a valid PUBCHEM ID." % db_id) - except ImportError: - pass + + pubchem_ids = { + db_id + for text, db_refs in gm.items() + for db_key, db_id in db_refs.items() + if db_key == 'PUBCHEM' + } + for db_id in tqdm(pubchem_ids): + res = requests.get(pubchem_url % db_id) + if res.status_code != 200: + print("ERROR: ID %s in grounding map is " + "not a valid PUBCHEM ID." % db_id) if signal_error: sys.exit(1) sys.exit(0) + + +if __name__ == '__main__': + main() diff --git a/famplex/reorganize_old_resources.py b/famplex/reorganize_old_resources.py index d405b3679..26f9569b2 100644 --- a/famplex/reorganize_old_resources.py +++ b/famplex/reorganize_old_resources.py @@ -28,8 +28,11 @@ FAMPLEX_DESCRIPTION = 'A protein family, complex, family of complexes,or complex of families' -client_lookups = [ +client_id_lookups = [ ('HGNC', hgnc_client.get_hgnc_id), +] + +client_name_lookups = [ ('UP', uniprot_client.get_mnemonic), ('GO', go_client.get_go_label), ('MESH', mesh_client.get_mesh_name), @@ -45,10 +48,14 @@ def get_id_label(db: str, db_id: str) -> Tuple[str, str]: if db == 'FPLX': return fplx_name_to_id[db_id], db_id - for client, lookup in client_lookups: + for client, lookup in client_id_lookups: if db == client: return lookup(db_id), db_id + for client, lookup in client_name_lookups: + if db == client: + return db_id, lookup(db_id) + else: return db_id, '.' diff --git a/famplex/resources/grounding_map.tsv b/famplex/resources/grounding_map.tsv index 4e7284c5e..13c030b4e 100644 --- a/famplex/resources/grounding_map.tsv +++ b/famplex/resources/grounding_map.tsv @@ -30,26 +30,26 @@ Na,K-ATPase FPLX 000303 Na_K_ATPase (9-1-1) complex FPLX 000001 9_1_1 14-3-3 proteins FPLX 000323 p14_3_3 14-3-3 FPLX 000323 p14_3_3 -14-3-3zeta UP 1433Z_HUMAN P63104 -4E-BP1 UP 4EBP1_HUMAN Q13541 +14-3-3zeta UP P63104 1433Z_HUMAN +4E-BP1 UP Q13541 4EBP1_HUMAN 4EBP FPLX 000154 EIF4EBP -4EBP1 UP 4EBP1_HUMAN Q13541 -53BP1 UP TP53B_HUMAN Q12888 +4EBP1 UP Q13541 4EBP1_HUMAN +53BP1 UP Q12888 TP53B_HUMAN 9-1-1 complex FPLX 000001 9_1_1 9-1-1 FPLX 000001 9_1_1 a-adrenoreceptor FPLX 000019 ADRA a-cathenin FPLX 000126 CTNNA A2t FPLX 000047 Annexin_II_heterotetramer ABA PUBCHEM 5280896 . -ABA CHEBI (+)-abscisic acid CHEBI:2365 -Abeta UP A4_HUMAN P05067 -Abeta CHEBI amyloid-beta CHEBI:64645 -Abi1 UP ABI1_HUMAN Q8IZP0 +ABA CHEBI CHEBI:2365 (+)-abscisic acid +Abeta UP P05067 A4_HUMAN +Abeta CHEBI CHEBI:64645 amyloid-beta +Abi1 UP Q8IZP0 ABI1_HUMAN ABL family FPLX 000003 ABL_family ABL FPLX 000003 ABL_family -Abl UP ABL1_HUMAN P00519 -AC MESH Adenocarcinoma D000230 -AC UP ADCY1_HUMAN Q08828 +Abl UP P00519 ABL1_HUMAN +AC MESH D000230 Adenocarcinoma +AC UP Q08828 ADCY1_HUMAN ACAD FPLX 000004 ACAD ACC FPLX 000005 ACC ACCs FPLX 000005 ACC @@ -63,7 +63,7 @@ Acetyl-CoA synthetase FPLX 000006 Acetyl_CoA_synthetase acetyl-CoA synthetase FPLX 000006 Acetyl_CoA_synthetase acetyl-coenzyme A synthase FPLX 000006 Acetyl_CoA_synthetase acetylcholine receptor FPLX 000102 CHRM -Ack1 UP ACK1_HUMAN Q07912 +Ack1 UP Q07912 ACK1_HUMAN ACS FPLX 000006 Acetyl_CoA_synthetase Acsl FPLX 000008 ACSL actin filament FPLX 000009 Actin @@ -90,40 +90,40 @@ adaptor protein complex 2 FPLX 000015 Adaptor_protein_II adaptor protein complex 3 FPLX 000016 Adaptor_protein_III adenylate cyclase FPLX 000017 ADCY adenylyl cyclase FPLX 000017 ADCY -adhesion GO cell adhesion GO:0007155 -adhesion MESH Cell Adhesion D002448 -adiponectin UP ADIPO_HUMAN Q15848 -ADP CHEBI ADP CHEBI:16761 +adhesion GO GO:0007155 cell adhesion +adhesion MESH D002448 Cell Adhesion +adiponectin UP Q15848 ADIPO_HUMAN +ADP CHEBI CHEBI:16761 ADP ADP PUBCHEM 6022 . ADP ribosylation factor FPLX 000053 ARF_GTPase_family afatinib PUBCHEM 10184653 . afatinib LINCS 10133-101 . -afatinib CHEBI afatinib CHEBI:61390 -AHR UP AHR_HUMAN P35869 +afatinib CHEBI CHEBI:61390 afatinib +AHR UP P35869 AHR_HUMAN AICAR PUBCHEM 65110 . -AICAR CHEBI AICA ribonucleotide CHEBI:18406 +AICAR CHEBI CHEBI:18406 AICA ribonucleotide AKT family FPLX 000023 AKT AKT FPLX 000023 AKT Akt FPLX 000023 AKT -AKT1 UP AKT1_HUMAN P31749 -Akt1 UP AKT1_HUMAN P31749 -AKT2 UP AKT2_HUMAN P31751 -Akt2 UP AKT2_HUMAN P31751 +AKT1 UP P31749 AKT1_HUMAN +Akt1 UP P31749 AKT1_HUMAN +AKT2 UP P31751 AKT2_HUMAN +Akt2 UP P31751 AKT2_HUMAN alcohol dehydrogenase FPLX 000018 ADH alcohol PUBCHEM 702 . -alcohol CHEBI ethanol CHEBI:16236 +alcohol CHEBI CHEBI:16236 ethanol alcohol HMDB HMDB00108 . aldehyde dehydrogenase (NAD+) FPLX 000024 ALDH Aldehyde dehydrogenase FPLX 000024 ALDH aldehyde dehydrogenase FPLX 000024 ALDH ALDH FPLX 000024 ALDH ALDO FPLX 000025 ALDO -aldosterone CHEBI aldosterone CHEBI:27584 +aldosterone CHEBI CHEBI:27584 aldosterone aldosterone PUBCHEM 5839 . ALG10 FPLX 000026 ALG10 ALIX HGNC 8766 PDCD6IP -ALIX UP PDC6I_HUMAN Q8WUM4 -ALK UP ALK_HUMAN Q9UM73 +ALIX UP Q8WUM4 PDC6I_HUMAN +ALK UP Q9UM73 ALK_HUMAN alkali myosin light chains FPLX 000297 MYL_alkali alpha adrenoceptor FPLX 000019 ADRA alpha catenin FPLX 000126 CTNNA @@ -159,14 +159,14 @@ alpha2beta1gamma1 FPLX 000038 AMPK_A2B1G1 alpha2beta2gamma1 FPLX 000041 AMPK_A2B2G1 alpha2beta2gamma2 FPLX 000042 AMPK_A2B2G2 alpha2beta2gamma3 FPLX 000043 AMPK_A2B2G3 -ALS UP ALS_HUMAN P35858 +ALS UP P35858 ALS_HUMAN AM HGNC 259 ADM -AM UP ADML_HUMAN P35318 -AM MESH Amnion D000650 -AMG655 MESH conatumumab C554537 +AM UP P35318 ADML_HUMAN +AM MESH D000650 Amnion +AMG655 MESH C554537 conatumumab AMLC FPLX 000297 MYL_alkali AMP HMDB HMDB00045 . -AMP CHEBI adenosine 5'-monophosphate CHEBI:16027 +AMP CHEBI CHEBI:16027 adenosine 5'-monophosphate AMP PUBCHEM 6083 . AMPA glutamate receptor FPLX 000191 GRIA AMPA receptor FPLX 000191 GRIA @@ -220,24 +220,24 @@ AMPK α2β2γ1 FPLX 000041 AMPK_A2B2G1 AMPK α2β2γ2 FPLX 000042 AMPK_A2B2G2 AMPK α2β2γ3 FPLX 000043 AMPK_A2B2G3 AMPK FPLX 000031 AMPK -AMPK-alpha1 UP AAPK1_HUMAN Q13131 -AMPK-alpha2 UP AAPK2_HUMAN P54646 -AMPK-α1 UP AAPK1_HUMAN Q13131 -AMPK-α2 UP AAPK2_HUMAN P54646 +AMPK-alpha1 UP Q13131 AAPK1_HUMAN +AMPK-alpha2 UP P54646 AAPK2_HUMAN +AMPK-α1 UP Q13131 AAPK1_HUMAN +AMPK-α2 UP P54646 AAPK2_HUMAN AMPKalpha FPLX 000044 AMPK_alpha -AMPKalpha1 catalytic domain UP AAPK1_HUMAN Q13131 -AMPKalpha1 UP AAPK1_HUMAN Q13131 +AMPKalpha1 catalytic domain UP Q13131 AAPK1_HUMAN +AMPKalpha1 UP Q13131 AAPK1_HUMAN AMPKα FPLX 000044 AMPK_alpha -AMPKα1 catalytic domain UP AAPK1_HUMAN Q13131 -AMPKα1 UP AAPK1_HUMAN Q13131 -amyloid beta UP A4_HUMAN P05067 -amyloid beta CHEBI amyloid-beta CHEBI:64645 -amyloid β UP A4_HUMAN P05067 -amyloid β CHEBI amyloid-beta CHEBI:64645 -Ang II UP ANGT_HUMAN P01019 -AngII UP ANGT_HUMAN P01019 -angiogenesis GO angiogenesis GO:0001525 -angiogenesis MESH Neovascularization, Physiologic D018919 +AMPKα1 catalytic domain UP Q13131 AAPK1_HUMAN +AMPKα1 UP Q13131 AAPK1_HUMAN +amyloid beta UP P05067 A4_HUMAN +amyloid beta CHEBI CHEBI:64645 amyloid-beta +amyloid β UP P05067 A4_HUMAN +amyloid β CHEBI CHEBI:64645 amyloid-beta +Ang II UP P01019 ANGT_HUMAN +AngII UP P01019 ANGT_HUMAN +angiogenesis GO GO:0001525 angiogenesis +angiogenesis MESH D018919 Neovascularization, Physiologic annexin A2 heterotetramer FPLX 000047 Annexin_II_heterotetramer annexin II heterotetramer FPLX 000047 Annexin_II_heterotetramer ANXA2 heterotetramer FPLX 000047 Annexin_II_heterotetramer @@ -253,14 +253,14 @@ AP2 clathrin adaptor complex FPLX 000015 Adaptor_protein_II AP2 complex FPLX 000015 Adaptor_protein_II AP2 FPLX 000015 Adaptor_protein_II AP3 FPLX 000016 Adaptor_protein_III -Apaf-1 UP APAF_HUMAN O14727 -APC UP APC_HUMAN P25054 +Apaf-1 UP O14727 APAF_HUMAN +APC UP P25054 APC_HUMAN APC/C FPLX 000050 APC_C -apigenin CHEBI apigenin CHEBI:18388 +apigenin CHEBI CHEBI:18388 apigenin apigenin PUBCHEM 5280443 . ApoA FPLX 000051 APOA apoA FPLX 000051 APOA -apocynin CHEBI apocynin CHEBI:2781 +apocynin CHEBI CHEBI:2781 apocynin apocynin PUBCHEM 2214 . apolipoprotein (a) FPLX 000051 APOA apolipoprotein A FPLX 000051 APOA @@ -269,83 +269,83 @@ apolipoprotein(a) FPLX 000051 APOA Apolipoprotein FPLX 000052 Apolipoprotein apolipoprotein FPLX 000052 Apolipoprotein apolipoproteins FPLX 000052 Apolipoprotein -Apoptosis GO apoptotic process GO:0006915 -Apoptosis MESH Apoptosis D017209 -apoptosis GO apoptotic process GO:0006915 -apoptosis MESH Apoptosis D017209 -AR UP ANDR_HUMAN P10275 +Apoptosis GO GO:0006915 apoptotic process +Apoptosis MESH D017209 Apoptosis +apoptosis GO GO:0006915 apoptotic process +apoptosis MESH D017209 Apoptosis +AR UP P10275 ANDR_HUMAN ARF FPLX 000053 ARF_GTPase_family -ARF UP ARF_HUMAN Q8N726 -Arf UP ARF_HUMAN Q8N726 +ARF UP Q8N726 ARF_HUMAN +Arf UP Q8N726 ARF_HUMAN Arp2/3 FPLX 000054 Arp2_3_protein -Arsenic trioxide CHEBI diarsenic trioxide CHEBI:30621 +Arsenic trioxide CHEBI CHEBI:30621 diarsenic trioxide Arsenic trioxide PUBCHEM 518605 . arsenic PUBCHEM 5359596 . -arsenic CHEBI arsenic atom CHEBI:27563 -arsenite CHEBI arsenite(3-) CHEBI:29866 +arsenic CHEBI CHEBI:27563 arsenic atom +arsenite CHEBI CHEBI:29866 arsenite(3-) arsenite PUBCHEM 544 . -artemisinin CHEBI (+)-artemisinin CHEBI:223316 +artemisinin CHEBI CHEBI:223316 (+)-artemisinin artemisinin PUBCHEM 68827 . -ASK1 UP M3K5_HUMAN Q99683 +ASK1 UP Q99683 M3K5_HUMAN aspirin PUBCHEM 2244 . -aspirin CHEBI acetylsalicylic acid CHEBI:15365 -ASPP1 UP ASPP1_HUMAN Q96KQ4 -ASPP2 UP ASPP2_HUMAN Q13625 -ATF2 UP ATF2_HUMAN P15336 +aspirin CHEBI CHEBI:15365 acetylsalicylic acid +ASPP1 UP Q96KQ4 ASPP1_HUMAN +ASPP2 UP Q13625 ASPP2_HUMAN +ATF2 UP P15336 ATF2_HUMAN ATG4 FPLX 000056 ATG4 Atg4 FPLX 000056 ATG4 -ATM UP ATM_HUMAN Q13315 +ATM UP Q13315 ATM_HUMAN ATP synthase H + transporting mitochondrial F0 complex subunit G FPLX 000059 ATP5G ATP synthase FPLX 000060 ATP_synthase ATP HMDB HMDB00538 . ATP PUBCHEM 5957 . -ATP CHEBI ATP CHEBI:15422 +ATP CHEBI CHEBI:15422 ATP ATP1A FPLX 000057 ATP1A ATP1B FPLX 000058 ATP1B ATPase Na+/K+ transporting subunit alpha FPLX 000057 ATP1A ATPase Na+/K+ transporting subunit beta FPLX 000057 ATP1A ATPase Na+/K+ transporting subunit α FPLX 000057 ATP1A ATPase Na+/K+ transporting subunit β FPLX 000057 ATP1A -ATR UP ATR_HUMAN Q13535 -ATRA CHEBI all-trans-retinoic acid CHEBI:15367 +ATR UP Q13535 ATR_HUMAN +ATRA CHEBI CHEBI:15367 all-trans-retinoic acid ATRA PUBCHEM 444795 . -autophagic cell death GO autophagic cell death GO:0048102 -Autophagy GO autophagy GO:0006914 -Autophagy MESH Autophagy D001343 -autophagy GO autophagy GO:0006914 -autophagy MESH Autophagy D001343 +autophagic cell death GO GO:0048102 autophagic cell death +Autophagy GO GO:0006914 autophagy +Autophagy MESH D001343 Autophagy +autophagy GO GO:0006914 autophagy +autophagy MESH D001343 Autophagy Axin FPLX 000062 AXIN -AZD6244 CHEBI selumetinib CHEBI:90227 +AZD6244 CHEBI CHEBI:90227 selumetinib AZD6244 PUBCHEM 10127622 . -Aβ UP A4_HUMAN P05067 -Aβ CHEBI amyloid-beta CHEBI:64645 +Aβ UP P05067 A4_HUMAN +Aβ CHEBI CHEBI:64645 amyloid-beta B3GAT FPLX 000063 B3GAT b-adrenergic receptor FPLX 000021 ADRB b-arrestin FPLX 000055 ARRB -B-Raf UP BRAF_HUMAN P15056 +B-Raf UP P15056 BRAF_HUMAN b-receptors FPLX 000021 ADRB -B1 UP PLXB1_HUMAN O43157 -B1 UP CCNB1_HUMAN P14635 -BAD UP BAD_HUMAN Q92934 -Bad UP BAD_HUMAN Q92934 -Bak UP BAK_HUMAN Q16611 -Bam32 UP DAPP1_HUMAN Q9UN19 +B1 UP O43157 PLXB1_HUMAN +B1 UP P14635 CCNB1_HUMAN +BAD UP Q92934 BAD_HUMAN +Bad UP Q92934 BAD_HUMAN +Bak UP Q16611 BAK_HUMAN +Bam32 UP Q9UN19 DAPP1_HUMAN BARK FPLX 000022 ADRBK barrestins FPLX 000055 ARRB -BAX UP BAX_HUMAN Q07812 -Bax UP BAX_HUMAN Q07812 +BAX UP Q07812 BAX_HUMAN +Bax UP Q07812 BAX_HUMAN BCKDC FPLX 000064 BCKDC BCKDH FPLX 000064 BCKDC -BCL-2 UP BCL2_HUMAN P10415 -Bcl-2 UP BCL2_HUMAN P10415 -bcl-2 UP BCL2_HUMAN P10415 +BCL-2 UP P10415 BCL2_HUMAN +Bcl-2 UP P10415 BCL2_HUMAN +bcl-2 UP P10415 BCL2_HUMAN Bcl-3 HGNC 998 BCL3 -Bcl-xL UP B2CL1_HUMAN Q07817 -BCL2 UP BCL2_HUMAN P10415 -Bcl2 UP BCL2_HUMAN P10415 -BCR UP BCR_HUMAN P11274 -Beclin-1 UP BECN1_HUMAN Q14457 -berberine CHEBI berberine CHEBI:16118 +Bcl-xL UP Q07817 B2CL1_HUMAN +BCL2 UP P10415 BCL2_HUMAN +Bcl2 UP P10415 BCL2_HUMAN +BCR UP P11274 BCR_HUMAN +Beclin-1 UP Q14457 BECN1_HUMAN +berberine CHEBI CHEBI:16118 berberine berberine PUBCHEM 2353 . Beta-1,3-glucuronyltransferase FPLX 000063 B3GAT Beta-1,3-glucuronyltransferases FPLX 000063 B3GAT @@ -367,8 +367,8 @@ beta Tubulin FPLX 000484 TUBB beta tubulin FPLX 000484 TUBB beta-adrenergic receptor FPLX 000021 ADRB beta-adrenoreceptor FPLX 000021 ADRB -beta-catenin UP CTNB1_HUMAN P35222 -beta-TrCP UP FBW1A_HUMAN Q9Y297 +beta-catenin UP P35222 CTNB1_HUMAN +beta-TrCP UP Q9Y297 FBW1A_HUMAN Beta-Tubulin FPLX 000484 TUBB Beta-tubulin FPLX 000484 TUBB beta-Tubulin FPLX 000484 TUBB @@ -376,23 +376,23 @@ beta-tubulin FPLX 000484 TUBB betaAR FPLX 000021 ADRB betaARK FPLX 000022 ADRBK BEZ235 PUBCHEM 11977753 . -BEZ235 CHEBI dactolisib CHEBI:71952 -bFGF UP FGF2_HUMAN P09038 -Bid UP BID_HUMAN P55957 -BIM UP B2L11_HUMAN O43521 -Bim UP B2L11_HUMAN O43521 -biosynthesis GO biosynthetic process GO:0009058 +BEZ235 CHEBI CHEBI:71952 dactolisib +bFGF UP P09038 FGF2_HUMAN +Bid UP P55957 BID_HUMAN +BIM UP O43521 B2L11_HUMAN +Bim UP O43521 B2L11_HUMAN +biosynthesis GO GO:0009058 biosynthetic process BIRs FPLX 000066 BIRC BITC PUBCHEM 2346 . -BITC CHEBI benzyl isothiocyanate CHEBI:17484 -BMF UP BMF_HUMAN Q96LC9 -BMI1 UP BMI1_HUMAN P35226 +BITC CHEBI CHEBI:17484 benzyl isothiocyanate +BMF UP Q96LC9 BMF_HUMAN +BMI1 UP P35226 BMI1_HUMAN BMP Receptor Type I FPLX 000069 BMP_receptor_type_I BMP Receptor Type II FPLX 000070 BMP_receptor_type_II BMP type I receptor FPLX 000069 BMP_receptor_type_I BMP type II receptor FPLX 000070 BMP_receptor_type_II BMP FPLX 000067 BMP -BMP9 UP GDF2_HUMAN Q9UK05 +BMP9 UP Q9UK05 GDF2_HUMAN bone morphogenetic protein I receptor FPLX 000069 BMP_receptor_type_I bone morphogenetic protein receptor 1 FPLX 000069 BMP_receptor_type_I bone morphogenetic protein receptor 2 FPLX 000070 BMP_receptor_type_II @@ -400,61 +400,61 @@ bone morphogenetic protein receptor type I FPLX 000069 BMP_receptor_type_I bone morphogenetic protein receptor type II FPLX 000070 BMP_receptor_type_II bone morphogenetic protein type I receptors FPLX 000069 BMP_receptor_type_I bone morphogenetic protein type II receptors FPLX 000070 BMP_receptor_type_II -bortezomib CHEBI bortezomib CHEBI:52717 +bortezomib CHEBI CHEBI:52717 bortezomib bortezomib PUBCHEM 387447 . -BPA CHEBI bisphenol A CHEBI:33216 +BPA CHEBI CHEBI:33216 bisphenol A BPA PUBCHEM 6623 . -BRAF UP BRAF_HUMAN P15056 +BRAF UP P15056 BRAF_HUMAN branched-chain alpha-keto acid dehydrogenase complex FPLX 000064 BCKDC branched-chain alpha-ketoacid dehydrogenase complex FPLX 000064 BCKDC branched-chain α-keto acid dehydrogenase complex FPLX 000064 BCKDC branched-chain α-ketoacid dehydrogenase complex FPLX 000064 BCKDC BRCA FPLX 000071 BRCA -BRCA1 UP BRCA1_HUMAN P38398 -BRCA2 UP BRCA2_HUMAN P51587 +BRCA1 UP P38398 BRCA1_HUMAN +BRCA2 UP P51587 BRCA2_HUMAN BRI FPLX 000069 BMP_receptor_type_I BRII FPLX 000070 BMP_receptor_type_II -BRSK1 UP BRSK1_HUMAN Q8TDC3 -BRSK2 UP BRSK2_HUMAN Q8IWQ3 -Bub1 UP BUB1_HUMAN O43683 -BubR1 UP BUB1B_HUMAN O60566 -butein CHEBI butein CHEBI:3237 +BRSK1 UP Q8TDC3 BRSK1_HUMAN +BRSK2 UP Q8IWQ3 BRSK2_HUMAN +Bub1 UP O43683 BUB1_HUMAN +BubR1 UP O60566 BUB1B_HUMAN +butein CHEBI CHEBI:3237 butein butein PUBCHEM 5281222 . -c-Abl Kinase UP ABL1_HUMAN P00519 -c-Abl UP ABL1_HUMAN P00519 -c-Cbl protein UP CBL_HUMAN P22681 -c-Cbl UP CBL_HUMAN P22681 -c-FLIP UP CFLAR_HUMAN O15519 -c-Fos UP FOS_HUMAN P01100 -c-fos UP FOS_HUMAN P01100 +c-Abl Kinase UP P00519 ABL1_HUMAN +c-Abl UP P00519 ABL1_HUMAN +c-Cbl protein UP P22681 CBL_HUMAN +c-Cbl UP P22681 CBL_HUMAN +c-FLIP UP O15519 CFLAR_HUMAN +c-Fos UP P01100 FOS_HUMAN +c-fos UP P01100 FOS_HUMAN c-JNK FPLX 000267 JNK c-Jun N-terminal kinase FPLX 000267 JNK c-Jun NH2-terminal kinase FPLX 000267 JNK -c-Jun UP JUN_HUMAN P05412 -c-jun UP JUN_HUMAN P05412 -C-MAF UP MAF_HUMAN O75444 -c-MAF UP MAF_HUMAN O75444 -c-Maf UP MAF_HUMAN O75444 -c-maf UP MAF_HUMAN O75444 +c-Jun UP P05412 JUN_HUMAN +c-jun UP P05412 JUN_HUMAN +C-MAF UP O75444 MAF_HUMAN +c-MAF UP O75444 MAF_HUMAN +c-Maf UP O75444 MAF_HUMAN +c-maf UP O75444 MAF_HUMAN c-MET HGNC 7029 MET c-met HGNC 7029 MET -c-Met UP MET_HUMAN P08581 -c-Myb UP MYB_HUMAN P10242 -c-myc oncogene UP MYC_HUMAN P01106 -c-myc proteins UP MYC_HUMAN P01106 -c-MYC UP MYC_HUMAN P01106 -c-Myc UP MYC_HUMAN P01106 -c-myc UP MYC_HUMAN P01106 -C-PARP UP PARP1_HUMAN P09874 -c-Raf UP RAF1_HUMAN P04049 +c-Met UP P08581 MET_HUMAN +c-Myb UP P10242 MYB_HUMAN +c-myc oncogene UP P01106 MYC_HUMAN +c-myc proteins UP P01106 MYC_HUMAN +c-MYC UP P01106 MYC_HUMAN +c-Myc UP P01106 MYC_HUMAN +c-myc UP P01106 MYC_HUMAN +C-PARP UP P09874 PARP1_HUMAN +c-Raf UP P04049 RAF1_HUMAN c-Rel HGNC 9954 REL c-src HGNC 11283 SRC -c-Src UP SRC_HUMAN P12931 +c-Src UP P12931 SRC_HUMAN C/EBP FPLX 000097 CEBP -C/EBPalpha UP CEBPA_HUMAN P49715 -C/EBPbeta UP CEBPB_HUMAN P17676 -C/EBPβ UP CEBPB_HUMAN P17676 -C/EBPα UP CEBPA_HUMAN P49715 +C/EBPalpha UP P49715 CEBPA_HUMAN +C/EBPbeta UP P17676 CEBPB_HUMAN +C/EBPβ UP P17676 CEBPB_HUMAN +C/EBPα UP P49715 CEBPA_HUMAN c1 complex FPLX 000072 C1 C1 FPLX 000072 C1 C1-complex FPLX 000072 C1 @@ -462,16 +462,16 @@ C1q FPLX 000073 C1q Ca(2+)-calmodulin-dependent protein kinase II FPLX 000077 CAMK2_complex Ca(2+)/calmodulin-dependent kinase II FPLX 000077 CAMK2_complex Ca HMDB HMDB00464 . -Ca CHEBI calcium(2+) CHEBI:29108 +Ca CHEBI CHEBI:29108 calcium(2+) Ca PUBCHEM 271 . cadherin FPLX 000074 Cadherin caffeine PUBCHEM 2519 . -caffeine CHEBI caffeine CHEBI:27732 +caffeine CHEBI CHEBI:27732 caffeine Calcineurin catalytic subunit FPLX 000384 PPP3C Calcineurin regulatory subunit FPLX 000385 PPP3R calcineurin FPLX 000383 PPP3 calcium HMDB HMDB00464 . -calcium CHEBI calcium(2+) CHEBI:29108 +calcium CHEBI CHEBI:29108 calcium(2+) calcium PUBCHEM 271 . Calmodulin FPLX 000075 CALM calmodulin FPLX 000075 CALM @@ -487,114 +487,114 @@ CaMK2 FPLX 000078 CAMK2_family CaMKII FPLX 000077 CAMK2_complex CAMKII FPLX 000078 CAMK2_family cAMP PUBCHEM 6076 . -cAMP CHEBI 3',5'-cyclic AMP CHEBI:17489 +cAMP CHEBI CHEBI:17489 3',5'-cyclic AMP cAMP HMDB HMDB00058 . cAMP-dependent PK FPLX 000363 PKA cAMP-dependent protein kinase FPLX 000363 PKA CaN FPLX 000383 PPP3 -CAP23 UP BASP1_HUMAN P80723 +CAP23 UP P80723 BASP1_HUMAN CAPE PUBCHEM 5281787 . -CAPE CHEBI phenethyl caffeate CHEBI:8062 +CAPE CHEBI CHEBI:8062 phenethyl caffeate capsaicin PUBCHEM 1548943 . -capsaicin CHEBI capsaicin CHEBI:3374 +capsaicin CHEBI CHEBI:3374 capsaicin carboxylesterase FPLX 000080 Carboxylesterase carboxylesterases FPLX 000080 Carboxylesterase -CARP-1 UP CCAR1_HUMAN Q8IX12 -Cas UP BCAR1_HUMAN P56945 +CARP-1 UP Q8IX12 CCAR1_HUMAN +Cas UP P56945 BCAR1_HUMAN Casein kinase 1 FPLX 000124 CSNK1 casein kinase 1 FPLX 000124 CSNK1 casein kinase 2 FPLX 000104 CK2 casein kinase I FPLX 000124 CSNK1 casein kinase II complex FPLX 000104 CK2 casein kinase II FPLX 000104 CK2 -caspase 3 UP CASP3_HUMAN P42574 -caspase 8 UP CASP8_HUMAN Q14790 +caspase 3 UP P42574 CASP3_HUMAN +caspase 8 UP Q14790 CASP8_HUMAN caspase FPLX 000081 Caspase -caspase-1 UP CASP1_HUMAN P29466 -Caspase-3 UP CASP3_HUMAN P42574 -caspase-3 UP CASP3_HUMAN P42574 +caspase-1 UP P29466 CASP1_HUMAN +Caspase-3 UP P42574 CASP3_HUMAN +caspase-3 UP P42574 CASP3_HUMAN caspase-3/7 FPLX 000082 Caspase_3_7 -caspase-8 UP CASP8_HUMAN Q14790 -caspase-9 UP CASP9_HUMAN P55211 +caspase-8 UP Q14790 CASP8_HUMAN +caspase-9 UP P55211 CASP9_HUMAN caspases FPLX 000081 Caspase -catalase UP CATA_HUMAN P04040 +catalase UP P04040 CATA_HUMAN catalytic subunit of calcineurin FPLX 000384 PPP3C catenin alpha FPLX 000126 CTNNA catenin α FPLX 000126 CTNNA Caveolin FPLX 000083 CAV caveolin FPLX 000083 CAV -caveolin-1 UP CAV1_HUMAN Q03135 +caveolin-1 UP Q03135 CAV1_HUMAN CBF3 complex FPLX 000084 CBF3 CBF3 FPLX 000084 CBF3 -Cbl UP CBL_HUMAN P22681 -Cbl-b UP CBLB_HUMAN Q13191 -CBP UP CBP_HUMAN Q92793 -Cby UP CBY1_HUMAN Q9Y3M2 +Cbl UP P22681 CBL_HUMAN +Cbl-b UP Q13191 CBLB_HUMAN +CBP UP Q92793 CBP_HUMAN +Cby UP Q9Y3M2 CBY1_HUMAN CCAAT/enhancer binding protein FPLX 000097 CEBP -CCN2 UP CTGF_HUMAN P29279 -CCND1 UP CCND1_HUMAN P24385 +CCN2 UP P29279 CTGF_HUMAN +CCND1 UP P24385 CCND1_HUMAN CCT complex FPLX 000085 CCT_complex CCT FPLX 000085 CCT_complex Cd PUBCHEM 23973 . -Cd CHEBI cadmium atom CHEBI:22977 +Cd CHEBI CHEBI:22977 cadmium atom CD16 FPLX 000086 CD16 -CD24 UP CD24_HUMAN P25063 -CD28 UP CD28_HUMAN P10747 +CD24 UP P25063 CD24_HUMAN +CD28 UP P10747 CD28_HUMAN CD3 FPLX 000087 CD3 CD32 FPLX 000088 CD32 -CD4 UP CD4_HUMAN P01730 -CD44 UP CD44_HUMAN P16070 +CD4 UP P01730 CD4_HUMAN +CD44 UP P16070 CD44_HUMAN CD64 FPLX 000089 CD64 CD8 FPLX 000090 CD8 -CD95 UP TNR6_HUMAN P25445 -Cdc20 UP CDC20_HUMAN Q12834 +CD95 UP P25445 TNR6_HUMAN +Cdc20 UP Q12834 CDC20_HUMAN CDC25 family FPLX 000091 CDC25 Cdc25 phosphatases FPLX 000091 CDC25 CDC25 FPLX 000091 CDC25 Cdc25 FPLX 000091 CDC25 -CDC42 UP CDC42_HUMAN P60953 -Cdc42 UP CDC42_HUMAN P60953 -Cdc6 UP CDC6_HUMAN Q99741 -CDDP CHEBI cisplatin CHEBI:27899 +CDC42 UP P60953 CDC42_HUMAN +Cdc42 UP P60953 CDC42_HUMAN +Cdc6 UP Q99741 CDC6_HUMAN +CDDP CHEBI CHEBI:27899 cisplatin CDDP PUBCHEM 441203 . CDK FPLX 000092 CDK Cdk FPLX 000092 CDK -CDK1 UP CDK1_HUMAN P06493 -Cdk1 UP CDK1_HUMAN P06493 -CDK2 UP CDK2_HUMAN P24941 -Cdk2 UP CDK2_HUMAN P24941 -cdk2 UP CDK2_HUMAN P24941 -CDK4 UP CDK4_HUMAN P11802 -Cdk4 UP CDK4_HUMAN P11802 -CDK6 UP CDK6_HUMAN Q00534 -CDK8 UP CDK8_HUMAN P49336 -CDK9 UP CDK9_HUMAN P50750 +CDK1 UP P06493 CDK1_HUMAN +Cdk1 UP P06493 CDK1_HUMAN +CDK2 UP P24941 CDK2_HUMAN +Cdk2 UP P24941 CDK2_HUMAN +cdk2 UP P24941 CDK2_HUMAN +CDK4 UP P11802 CDK4_HUMAN +Cdk4 UP P11802 CDK4_HUMAN +CDK6 UP Q00534 CDK6_HUMAN +CDK8 UP P49336 CDK8_HUMAN +CDK9 UP P50750 CDK9_HUMAN CDKN FPLX 000094 CDKN CDKN1 FPLX 000095 CDKN1 -CDKN1A UP CDN1A_HUMAN P38936 +CDKN1A UP P38936 CDN1A_HUMAN CDKN2 FPLX 000096 CDKN2 CDKs FPLX 000092 CDK celecoxib PUBCHEM 2662 . -celecoxib CHEBI celecoxib CHEBI:41423 -cell adhesion GO cell adhesion GO:0007155 -cell adhesion MESH Cell Adhesion D002448 -cell cycle GO cell cycle GO:0007049 -cell cycle MESH Cell Cycle D002453 -cell death GO cell death GO:0008219 -cell death MESH Cell Death D016923 -cell growth GO cell growth GO:0016049 -cell growth MESH Cell Growth Processes D048708 -cell migration GO cell migration GO:0016477 -cell migration MESH Cell Movement D002465 -cell motility GO cell migration GO:0016477 -cell motility MESH Cell Movement D002465 -cell proliferation GO cell population proliferation GO:0008283 -cell proliferation MESH Cell Proliferation D049109 -cell survival MESH Cell Survival D002470 -cell viability MESH Cell Survival D002470 -cellular senescence GO cellular senescence GO:0090398 -cellular senescence MESH Cellular Senescence D016922 -ceramide CHEBI ceramide CHEBI:17761 +celecoxib CHEBI CHEBI:41423 celecoxib +cell adhesion GO GO:0007155 cell adhesion +cell adhesion MESH D002448 Cell Adhesion +cell cycle GO GO:0007049 cell cycle +cell cycle MESH D002453 Cell Cycle +cell death GO GO:0008219 cell death +cell death MESH D016923 Cell Death +cell growth GO GO:0016049 cell growth +cell growth MESH D048708 Cell Growth Processes +cell migration GO GO:0016477 cell migration +cell migration MESH D002465 Cell Movement +cell motility GO GO:0016477 cell migration +cell motility MESH D002465 Cell Movement +cell proliferation GO GO:0008283 cell population proliferation +cell proliferation MESH D049109 Cell Proliferation +cell survival MESH D002470 Cell Survival +cell viability MESH D002470 Cell Survival +cellular senescence GO GO:0090398 cellular senescence +cellular senescence MESH D016922 Cellular Senescence +ceramide CHEBI CHEBI:17761 ceramide cetuximab CHEMBL 1201577 . CFM-4 PUBCHEM 2871439 . chaperonin containing TCP-1 FPLX 000085 CCT_complex @@ -605,21 +605,21 @@ checkpoint kinase FPLX 000098 CHEK chemoattractant receptor FPLX 000100 Chemokine_receptor chemokine FPLX 000099 Chemokine chemokines FPLX 000099 Chemokine -CHIP UP CHIP_HUMAN Q9UNE7 -CHK1 UP CHK1_HUMAN O14757 -Chk1 UP CHK1_HUMAN O14757 -CHK2 UP CHK2_HUMAN O96017 -Chk2 UP CHK2_HUMAN O96017 -cholesterol CHEBI cholesterol CHEBI:16113 +CHIP UP Q9UNE7 CHIP_HUMAN +CHK1 UP O14757 CHK1_HUMAN +Chk1 UP O14757 CHK1_HUMAN +CHK2 UP O96017 CHK2_HUMAN +Chk2 UP O96017 CHK2_HUMAN +cholesterol CHEBI CHEBI:16113 cholesterol cholesterol PUBCHEM 5997 . choline esterase FPLX 000101 Cholinesterase cholinesterase FPLX 000101 Cholinesterase -CHOP UP DDIT3_HUMAN P35638 -CIP1 UP CDN1A_HUMAN P38936 -CIP2A UP CIP2A_HUMAN Q8TCG1 -Cisplatin CHEBI cisplatin CHEBI:27899 +CHOP UP P35638 DDIT3_HUMAN +CIP1 UP P38936 CDN1A_HUMAN +CIP2A UP Q8TCG1 CIP2A_HUMAN +Cisplatin CHEBI CHEBI:27899 cisplatin Cisplatin PUBCHEM 441203 . -cisplatin CHEBI cisplatin CHEBI:27899 +cisplatin CHEBI CHEBI:27899 cisplatin cisplatin PUBCHEM 441203 . CK2 FPLX 000104 CK2 CKI FPLX 000094 CDKN @@ -655,15 +655,15 @@ class IV HDACs FPLX 000224 HDAC_IV class IV histone deacetylases FPLX 000224 HDAC_IV clathrin coat FPLX 000105 Clathrin clathrin FPLX 000105 Clathrin -cleaved PARP UP PARP1_HUMAN P09874 -cMet receptor UP MET_HUMAN P08581 +cleaved PARP UP P09874 PARP1_HUMAN +cMet receptor UP P08581 MET_HUMAN CNKSR FPLX 000106 CNKSR -CO 2 CHEBI carbon dioxide CHEBI:16526 +CO 2 CHEBI CHEBI:16526 carbon dioxide CO 2 PUBCHEM 280 . -CO CHEBI carbon monoxide CHEBI:17245 +CO CHEBI CHEBI:17245 carbon monoxide CO PUBCHEM 281 . cocaine PUBCHEM 446220 . -cocaine CHEBI cocaine CHEBI:27958 +cocaine CHEBI CHEBI:27958 cocaine cofilin FPLX 000107 Cofilin cohesin complex FPLX 000108 Cohesin cohesin FPLX 000108 Cohesin @@ -679,17 +679,17 @@ collagen type I FPLX 000109 COL1 Collagen Type IV FPLX 000110 COL4 collagen type IV FPLX 000110 COL4 collagen type V FPLX 000111 COL5 -collagen MESH Collagen D003094 -collagen CHEBI Collagen CHEBI:3815 +collagen MESH D003094 Collagen +collagen CHEBI CHEBI:3815 Collagen complex II FPLX 000502 ETC_complex_II complex III FPLX 000503 ETC_complex_III Complex IV FPLX 000113 COX connector enhancer of kinase suppressor of ras FPLX 000106 CNKSR -copper CHEBI copper(2+) CHEBI:29036 +copper CHEBI CHEBI:29036 copper(2+) copper PUBCHEM 27099 . cortactin IP IPR015503 . -cortactin UP SRC8_HUMAN Q14247 -COX-2 UP PGH2_HUMAN P35354 +cortactin UP Q14247 SRC8_HUMAN +COX-2 UP P35354 PGH2_HUMAN Cox4 FPLX 000114 COX4 COX6A FPLX 000115 COX6A Cox6a FPLX 000115 COX6A @@ -698,45 +698,45 @@ COX7A FPLX 000117 COX7A Cox7a FPLX 000117 COX7A Cox7b FPLX 000118 COX7B Cox8 FPLX 000119 COX8 -cPARP UP PARP1_HUMAN P09874 +cPARP UP P09874 PARP1_HUMAN cPLA2 FPLX 000366 PLA2 -CRAF UP RAF1_HUMAN P04049 +CRAF UP P04049 RAF1_HUMAN CREB family FPLX 000120 CREB CREB FPLX 000120 CREB CRISP FPLX 000121 CRISP CRISPs FPLX 000121 CRISP -Crk UP CRK_HUMAN P46108 +Crk UP P46108 CRK_HUMAN CRSP complex FPLX 000122 CRSP CRSP FPLX 000122 CRSP CRSP/Med complex FPLX 000122 CRSP CsA PUBCHEM 5284373 . -CsA CHEBI cyclosporin A CHEBI:4031 -CSC MESH Neoplastic Stem Cells D014411 -CSF-1R UP CSF1R_HUMAN P07333 +CsA CHEBI CHEBI:4031 cyclosporin A +CSC MESH D014411 Neoplastic Stem Cells +CSF-1R UP P07333 CSF1R_HUMAN CSNK1 FPLX 000124 CSNK1 CSNK2 FPLX 000125 CSNK2 -CtIP UP CTIP_HUMAN Q99708 +CtIP UP Q99708 CTIP_HUMAN cTnC FPLX 000478 Troponin_C cTnI FPLX 000478 Troponin_C cTnT FPLX 000480 Troponin_T cullin proteins FPLX 000127 CUL cullin FPLX 000127 CUL cullins FPLX 000127 CUL -Curcumin CHEBI curcumin CHEBI:3962 +Curcumin CHEBI CHEBI:3962 curcumin Curcumin PUBCHEM 969516 . -curcumin CHEBI curcumin CHEBI:3962 +curcumin CHEBI CHEBI:3962 curcumin curcumin PUBCHEM 969516 . -CXCL12 UP SDF1_HUMAN P48061 -CXCL8 UP IL8_HUMAN P10145 -CXCR2 UP CXCR2_HUMAN P25025 -CXCR4 UP CXCR4_HUMAN P61073 +CXCL12 UP P48061 SDF1_HUMAN +CXCL8 UP P10145 IL8_HUMAN +CXCR2 UP P25025 CXCR2_HUMAN +CXCR4 UP P61073 CXCR4_HUMAN cyclic AMP-dependent protein kinase FPLX 000363 PKA cyclic-AMP-dependent protein kinase FPLX 000363 PKA Cyclin A FPLX 000131 Cyclin_A cyclin A FPLX 000131 Cyclin_A Cyclin D FPLX 000132 Cyclin_D -Cyclin D2 UP CCND2_HUMAN P30279 -cyclin D2 UP CCND2_HUMAN P30279 +Cyclin D2 UP P30279 CCND2_HUMAN +cyclin D2 UP P30279 CCND2_HUMAN cyclin dependent kinase inhibitors FPLX 000094 CDKN cyclin E FPLX 000133 Cyclin_E cyclin family FPLX 000130 Cyclin @@ -748,8 +748,8 @@ cyclin-dependent protein kinase inhibitors FPLX 000094 CDKN cyclins FPLX 000130 Cyclin cyclophilin FPLX 000134 Cyclophilin cyclophilins FPLX 000134 Cyclophilin -CYLD UP CYLD_HUMAN Q9NQC7 -cypermethrin CHEBI cypermethrin CHEBI:4042 +CYLD UP Q9NQC7 CYLD_HUMAN +cypermethrin CHEBI CHEBI:4042 cypermethrin cypermethrin PUBCHEM 2912 . cysteine rich secretory proteins FPLX 000121 CRISP cysteine-rich secretory proteins FPLX 000121 CRISP @@ -757,52 +757,52 @@ cytochrome bc1 complex FPLX 000503 ETC_complex_III Cytochrome c oxidase subunit 6a FPLX 000115 COX6A cytochrome c oxidase subunit VIII FPLX 000119 COX8 cytochrome c oxidase FPLX 000113 COX -cytochrome C UP CYC_HUMAN P99999 -cytochrome c UP CYC_HUMAN P99999 -cytokine production GO cytokine production GO:0001816 +cytochrome C UP P99999 CYC_HUMAN +cytochrome c UP P99999 CYC_HUMAN +cytokine production GO GO:0001816 cytokine production cytoplasmic dynein FPLX 000135 Cytoplasmic_dynein cytosolic phospholipase A(2) FPLX 000366 PLA2 cytosolic phospholipase A2 FPLX 000366 PLA2 cytosolic PLA2 FPLX 000366 PLA2 DA PUBCHEM 681 . -DA CHEBI dopamine CHEBI:18243 +DA CHEBI CHEBI:18243 dopamine dabrafenib PUBCHEM 44462760 . -dabrafenib CHEBI dabrafenib CHEBI:75045 +dabrafenib CHEBI CHEBI:75045 dabrafenib DAG kinase FPLX 000140 DGK DAG PUBCHEM 6026790 . -DAG CHEBI diacylglycerol 30:1 CHEBI:85682 -damage MESH DNA Damage D004249 +DAG CHEBI CHEBI:85682 diacylglycerol 30:1 +damage MESH D004249 DNA Damage Danusertib PUBCHEM 11442891 . Danusertib CHEMBL CHEMBL402548 . -Danusertib CHEBI N-[5-[(2R)-2-methoxy-1-oxo-2-phenylethyl]-4,6-dihydro-1H-pyrrolo[3,4-c]pyrazol-3-yl]-4-(4-methyl-1-piperazinyl)benzamide CHEBI:94490 +Danusertib CHEBI CHEBI:94490 N-[5-[(2R)-2-methoxy-1-oxo-2-phenylethyl]-4,6-dihydro-1H-pyrrolo[3,4-c]pyrazol-3-yl]-4-(4-methyl-1-piperazinyl)benzamide danusertib PUBCHEM 11442891 . danusertib CHEMBL CHEMBL402548 . -danusertib CHEBI N-[5-[(2R)-2-methoxy-1-oxo-2-phenylethyl]-4,6-dihydro-1H-pyrrolo[3,4-c]pyrazol-3-yl]-4-(4-methyl-1-piperazinyl)benzamide CHEBI:94490 -dapagliflozin CHEBI dapagliflozin CHEBI:85078 +danusertib CHEBI CHEBI:94490 N-[5-[(2R)-2-methoxy-1-oxo-2-phenylethyl]-4,6-dihydro-1H-pyrrolo[3,4-c]pyrazol-3-yl]-4-(4-methyl-1-piperazinyl)benzamide +dapagliflozin CHEBI CHEBI:85078 dapagliflozin dapagliflozin PUBCHEM 9887712 . -dasatinib CHEBI dasatinib (anhydrous) CHEBI:49375 +dasatinib CHEBI CHEBI:49375 dasatinib (anhydrous) dasatinib PUBCHEM 3062316 . -DDR GO DNA damage response, detection of DNA damage GO:0042769 +DDR GO GO:0042769 DNA damage response, detection of DNA damage death receptor FPLX 000137 Death_receptor death receptors FPLX 000137 Death_receptor -death GO cell death GO:0008219 -death MESH Cell Death D016923 +death GO GO:0008219 cell death +death MESH D016923 Cell Death delta-tubulin HGNC 16811 TUBD1 desmoglein FPLX 000138 Desmoglein desmogleins FPLX 000138 Desmoglein dexamethasone PUBCHEM 5743 . -dexamethasone CHEBI dexamethasone CHEBI:41879 +dexamethasone CHEBI CHEBI:41879 dexamethasone DGC FPLX 000139 DGC DGK FPLX 000140 DGK -DHA CHEBI dihydroartemisinin CHEBI:207229 +DHA CHEBI CHEBI:207229 dihydroartemisinin DHA PUBCHEM 6918483 . DHT PUBCHEM 11302 . -DHT CHEBI 5beta-dihydrotestosterone CHEBI:2150 +DHT CHEBI CHEBI:2150 5beta-dihydrotestosterone diacyl glycerol kinase FPLX 000140 DGK diacylglycerol kinase FPLX 000140 DGK -differentiation GO cell differentiation GO:0030154 -differentiation MESH Cell Differentiation D002454 -diosmetin CHEBI diosmetin CHEBI:4630 +differentiation GO GO:0030154 cell differentiation +differentiation MESH D002454 Cell Differentiation +diosmetin CHEBI CHEBI:4630 diosmetin diosmetin PUBCHEM 5281612 . discoidin domain receptor family FPLX 000136 DDR discoidin domain receptors FPLX 000136 DDR @@ -810,30 +810,30 @@ discoidin domain-containing receptor FPLX 000136 DDR dishevelled FPLX 000145 DVL DNA polymerase delta FPLX 000141 DNA_polymerase_delta DNA polymerase δ FPLX 000141 DNA_polymerase_delta -DNA repair GO DNA repair GO:0006281 -DNA repair MESH DNA Repair D004260 +DNA repair GO GO:0006281 DNA repair +DNA repair MESH D004260 DNA Repair DNA replication factor C complex FPLX 000411 RFC DNA replication factor C FPLX 000411 RFC -DNA-PKcs UP PRKDC_HUMAN P78527 -DNA-Pkcs UP PRKDC_HUMAN P78527 +DNA-PKcs UP P78527 PRKDC_HUMAN +DNA-Pkcs UP P78527 PRKDC_HUMAN docetaxel PUBCHEM 148124 . -docetaxel CHEBI docetaxel anhydrous CHEBI:4672 -Dok1 UP DOK1_HUMAN Q99704 -Dok2 UP DOK2_HUMAN O60496 +docetaxel CHEBI CHEBI:4672 docetaxel anhydrous +Dok1 UP Q99704 DOK1_HUMAN +Dok2 UP O60496 DOK2_HUMAN dopamine receptor FPLX 000143 DRD dopamine receptors FPLX 000143 DRD dopamine PUBCHEM 681 . -dopamine CHEBI dopamine CHEBI:18243 -doxorubicin CHEBI doxorubicin CHEBI:28748 +dopamine CHEBI CHEBI:18243 dopamine +doxorubicin CHEBI CHEBI:28748 doxorubicin doxorubicin PUBCHEM 31703 . doxycycline PUBCHEM 54671203 . -doxycycline CHEBI doxycycline CHEBI:50845 +doxycycline CHEBI CHEBI:50845 doxycycline DP complex FPLX 000464 TFDP -DR4 UP TR10A_HUMAN O00220 -DR5 UP TR10B_HUMAN O14763 -DSB MESH DNA Breaks, Double-Stranded D053903 +DR4 UP O00220 TR10A_HUMAN +DR5 UP O14763 TR10B_HUMAN +DSB MESH D053903 DNA Breaks, Double-Stranded DUSP FPLX 000144 DUSP -DUSP1 UP DUS1_HUMAN P28562 +DUSP1 UP P28562 DUS1_HUMAN Dvl FPLX 000145 DVL dynamin family FPLX 000142 DNM dynamin FPLX 000142 DNM @@ -841,120 +841,120 @@ dystrophin glycoprotein complex FPLX 000139 DGC dystrophin glycoprotein FPLX 000139 DGC dystrophin-associated glycoprotein complex FPLX 000139 DGC dystrophin-glycoprotein complex FPLX 000139 DGC -E-cadherin UP CADH1_HUMAN P12830 +E-cadherin UP P12830 CADH1_HUMAN E2 enzyme FPLX 000489 UBE2 E2 ubiquitin-conjugating enzyme FPLX 000489 UBE2 E2 FPLX 000489 UBE2 -E2 UP POLG_HCVH P27958 +E2 UP P27958 POLG_HCVH E2F FPLX 000147 E2F -E2F-1 UP E2F1_HUMAN Q01094 -E2F1 UP E2F1_HUMAN Q01094 +E2F-1 UP Q01094 E2F1_HUMAN +E2F1 UP Q01094 E2F1_HUMAN E3 ubiquitin ligase FPLX 000148 E3_Ub_ligase E3 FPLX 000148 E3_Ub_ligase -E6 UP VE6_HPV16 P03126 -E7 UP VE7_HPV16 P03129 +E6 UP P03126 VE6_HPV16 +E7 UP P03129 VE7_HPV16 early growth response proteins FPLX 000151 EGR -EBNA3C UP None I1YP21 -ECM GO extracellular matrix GO:0031012 -Ect2 UP ECT2_HUMAN Q9H8V3 +EBNA3C UP I1YP21 None +ECM GO GO:0031012 extracellular matrix +Ect2 UP Q9H8V3 ECT2_HUMAN EGCG PUBCHEM 65064 . -EGCG CHEBI (-)-epigallocatechin 3-gallate CHEBI:4806 -EGF receptor UP EGFR_HUMAN P00533 -EGF UP EGF_HUMAN P01133 +EGCG CHEBI CHEBI:4806 (-)-epigallocatechin 3-gallate +EGF receptor UP P00533 EGFR_HUMAN +EGF UP P01133 EGF_HUMAN EGFR ligand FPLX 000150 EGFR_ligand EGFR ligands FPLX 000150 EGFR_ligand -EGFR UP EGFR_HUMAN P00533 -EGFRvIII UP EGFR_HUMAN P00533 +EGFR UP P00533 EGFR_HUMAN +EGFRvIII UP P00533 EGFR_HUMAN EGR FPLX 000151 EGR -eIF2alpha UP IF2A_HUMAN P05198 +eIF2alpha UP P05198 IF2A_HUMAN EIF2B FPLX 000152 EIF2B eIF2B FPLX 000152 EIF2B -eIF2α UP IF2A_HUMAN P05198 +eIF2α UP P05198 IF2A_HUMAN eIF4A FPLX 000153 EIF4A -eIF4E UP IF4E_HUMAN P06730 +eIF4E UP P06730 IF4E_HUMAN eIF4G FPLX 000155 EIF4G elastase FPLX 000156 ELA -Elk-1 UP ELK1_HUMAN P19419 -Elk1 UP ELK1_HUMAN P19419 -ELMO1 UP ELMO1_HUMAN Q92556 +Elk-1 UP P19419 ELK1_HUMAN +Elk1 UP P19419 ELK1_HUMAN +ELMO1 UP Q92556 ELMO1_HUMAN ELR (+) CXC chemokines FPLX 000129 CXCL_ELR_positive ELR (-) CXC chemokines FPLX 000128 CXCL_ELR_negative ELR-negative CXC chemokine FPLX 000128 CXCL_ELR_negative ELR-negative CXC family FPLX 000128 CXCL_ELR_negative ELR-positive CXC chemokine FPLX 000129 CXCL_ELR_positive ELR-positive CXC family FPLX 000129 CXCL_ELR_positive -embelin CHEBI embelin CHEBI:4778 +embelin CHEBI CHEBI:4778 embelin embelin PUBCHEM 3218 . emodin PUBCHEM 3220 . -emodin CHEBI emodin CHEBI:42223 -EMT GO epithelial to mesenchymal transition GO:0001837 -EMT MESH Epithelial-Mesenchymal Transition D058750 -endocytosis GO endocytosis GO:0006897 -endocytosis MESH Endocytosis D004705 +emodin CHEBI CHEBI:42223 emodin +EMT GO GO:0001837 epithelial to mesenchymal transition +EMT MESH D058750 Epithelial-Mesenchymal Transition +endocytosis GO GO:0006897 endocytosis +endocytosis MESH D004705 Endocytosis endothelin FPLX 000149 EDN endothelins FPLX 000149 EDN enolase FPLX 000157 ENO -eNOS UP NOS3_HUMAN P29474 -Env UP None U3LIR9 +eNOS UP P29474 NOS3_HUMAN +Env UP U3LIR9 None Eph receptor FPLX 000158 Ephrin_receptor Eph receptors FPLX 000158 Ephrin_receptor -EphA2 UP EPHA2_HUMAN P29317 -EphB1 UP EPHB1_HUMAN P54762 +EphA2 UP P29317 EPHA2_HUMAN +EphB1 UP P54762 EPHB1_HUMAN ephrin receptor FPLX 000158 Ephrin_receptor -epidermal growth factor receptor UP EGFR_HUMAN P00533 -epidermal growth factor UP EGF_HUMAN P01133 -Eps8 UP EPS8_HUMAN Q12929 +epidermal growth factor receptor UP P00533 EGFR_HUMAN +epidermal growth factor UP P01133 EGF_HUMAN +Eps8 UP Q12929 EPS8_HUMAN epsilon-tubulin HGNC 20775 TUBE1 epsin FPLX 000159 EPN epsins FPLX 000159 EPN ER FPLX 000162 ESR -ER MESH Endoplasmic Reticulum D004721 -ER GO endoplasmic reticulum GO:0005783 -ER UP ESR1_HUMAN P03372 -ERalpha UP ESR1_HUMAN P03372 +ER MESH D004721 Endoplasmic Reticulum +ER GO GO:0005783 endoplasmic reticulum +ER UP P03372 ESR1_HUMAN +ERalpha UP P03372 ESR1_HUMAN ErbB FPLX 000160 ERBB -ERBB2 UP ERBB2_HUMAN P04626 -ErbB2 UP ERBB2_HUMAN P04626 -ErbB3 UP ERBB3_HUMAN P21860 +ERBB2 UP P04626 ERBB2_HUMAN +ErbB2 UP P04626 ERBB2_HUMAN +ErbB3 UP P21860 ERBB3_HUMAN ERK 1/2 FPLX 000161 ERK -ERK inhibitors CHEBI EC 2.7.11.24 (mitogen-activated protein kinase) inhibitor CHEBI:79091 +ERK inhibitors CHEBI CHEBI:79091 EC 2.7.11.24 (mitogen-activated protein kinase) inhibitor ERK MAPK FPLX 000161 ERK ERK mitogen-activated protein kinase FPLX 000161 ERK ERK FPLX 000161 ERK Erk FPLX 000161 ERK ERK-1/2 FPLX 000161 ERK -ERK1 UP MK03_HUMAN P27361 -Erk1 UP MK03_HUMAN P27361 +ERK1 UP P27361 MK03_HUMAN +Erk1 UP P27361 MK03_HUMAN ERK1/2 MAPK FPLX 000161 ERK ERK1/2 FPLX 000161 ERK Erk1/2 FPLX 000161 ERK -ERK2 UP MK01_HUMAN P28482 -ERK5 UP MK07_HUMAN Q13164 +ERK2 UP P28482 MK01_HUMAN +ERK5 UP Q13164 MK07_HUMAN ERKs FPLX 000161 ERK erlotinib PUBCHEM 176870 . -erlotinib CHEBI erlotinib CHEBI:114785 -ERα UP ESR1_HUMAN P03372 +erlotinib CHEBI CHEBI:114785 erlotinib +ERα UP P03372 ESR1_HUMAN ESR FPLX 000162 ESR -estradiol CHEBI estradiol CHEBI:23965 +estradiol CHEBI CHEBI:23965 estradiol estradiol PUBCHEM 9811784 . -estrogen receptor UP ESR1_HUMAN P03372 -estrogen CHEBI estrogen CHEBI:50114 -ET-1 UP EDN1_HUMAN P05305 +estrogen receptor UP P03372 ESR1_HUMAN +estrogen CHEBI CHEBI:50114 estrogen +ET-1 UP P05305 EDN1_HUMAN ethanol PUBCHEM 702 . -ethanol CHEBI ethanol CHEBI:16236 +ethanol CHEBI CHEBI:16236 ethanol ethanol HMDB HMDB00108 . etoposide PUBCHEM 36462 . -etoposide CHEBI etoposide CHEBI:4911 +etoposide CHEBI CHEBI:4911 etoposide ETS FPLX 000163 ETS -ETS-1 UP ETS1_HUMAN P14921 -Ets-1 UP ETS1_HUMAN P14921 -ETS1 UP ETS1_HUMAN P14921 -eukaryotic initiation factor 4E UP IF4E_HUMAN P06730 +ETS-1 UP P14921 ETS1_HUMAN +Ets-1 UP P14921 ETS1_HUMAN +ETS1 UP P14921 ETS1_HUMAN +eukaryotic initiation factor 4E UP P06730 IF4E_HUMAN eukaryotic initiation factor-4A FPLX 000153 EIF4A Everolimus PUBCHEM 6442177 . -Everolimus CHEBI everolimus CHEBI:68478 +Everolimus CHEBI CHEBI:68478 everolimus everolimus PUBCHEM 6442177 . -everolimus CHEBI everolimus CHEBI:68478 +everolimus CHEBI CHEBI:68478 everolimus EXOC FPLX 000164 EXOC exocyst complex FPLX 000164 EXOC exocyst FPLX 000164 EXOC @@ -963,49 +963,49 @@ exostosin glycosyltransferase family FPLX 000165 EXT EXT FPLX 000165 EXT Extracellular Signal Regulated Kinase FPLX 000161 ERK extracellular signal-regulated kinase FPLX 000161 ERK -EZH2 UP EZH2_HUMAN Q15910 -ezrin UP EZRI_HUMAN P15311 +EZH2 UP Q15910 EZH2_HUMAN +ezrin UP P15311 EZRI_HUMAN F-actin FPLX 000178 F_actin -FADD UP FADD_HUMAN Q13158 -FAK UP FAK1_HUMAN Q05397 -FAM83B UP FA83B_HUMAN Q5T0W9 +FADD UP Q13158 FADD_HUMAN +FAK UP Q05397 FAK1_HUMAN +FAM83B UP Q5T0W9 FA83B_HUMAN FANC proteins FPLX 000166 FANC FANC FPLX 000166 FANC -FANCJ UP FANCJ_HUMAN Q9BX63 +FANCJ UP Q9BX63 FANCJ_HUMAN farnesyltransferase FPLX 000172 FNT -Fas UP TNR6_HUMAN P25445 -FasL UP TNFL6_HUMAN P48023 +Fas UP P25445 TNR6_HUMAN +FasL UP P48023 TNFL6_HUMAN FGF FPLX 000167 FGF -FGF-2 UP FGF2_HUMAN P09038 -FGF2 UP FGF2_HUMAN P09038 +FGF-2 UP P09038 FGF2_HUMAN +FGF2 UP P09038 FGF2_HUMAN FGFR FPLX 000168 FGFR -FGFR1 UP FGFR1_HUMAN P11362 -FGFR2 UP FGFR2_HUMAN P21802 -FGFR3 UP FGFR3_HUMAN P22607 -FGFR4 UP FGFR4_HUMAN P22455 +FGFR1 UP P11362 FGFR1_HUMAN +FGFR2 UP P21802 FGFR2_HUMAN +FGFR3 UP P22607 FGFR3_HUMAN +FGFR4 UP P22455 FGFR4_HUMAN fibrinogen FPLX 000169 Fibrinogen -fibronectin UP FINC_HUMAN P02751 -fisetin CHEBI fisetin CHEBI:42567 +fibronectin UP P02751 FINC_HUMAN +fisetin CHEBI CHEBI:42567 fisetin fisetin PUBCHEM 5281614 . -Flip UP CFLAR_HUMAN O15519 +Flip UP O15519 CFLAR_HUMAN flotillin FPLX 000170 FLOT FLRT family FPLX 000171 FLRT Flrt family FPLX 000171 FLRT FLRT proteins FPLX 000171 FLRT -FLT3 UP FLT3_HUMAN P36888 -FN UP FINC_HUMAN P02751 +FLT3 UP P36888 FLT3_HUMAN +FN UP P02751 FINC_HUMAN follicle-stimulating hormone FPLX 000175 FSH FOS FPLX 000173 FOS_family Fos FPLX 000173 FOS_family -FOXM1 UP FOXM1_HUMAN Q08050 +FOXM1 UP Q08050 FOXM1_HUMAN FOXO FPLX 000174 FOXO FoxO FPLX 000174 FOXO -FOXO1 UP FOXO1_HUMAN Q12778 -FoxO1 UP FOXO1_HUMAN Q12778 -FOXO3 UP FOXO3_HUMAN O43524 -FOXO3a UP FOXO3_HUMAN O43524 -FoxO3a UP FOXO3_HUMAN O43524 -FRK UP FRK_HUMAN P42685 +FOXO1 UP Q12778 FOXO1_HUMAN +FoxO1 UP Q12778 FOXO1_HUMAN +FOXO3 UP O43524 FOXO3_HUMAN +FOXO3a UP O43524 FOXO3_HUMAN +FoxO3a UP O43524 FOXO3_HUMAN +FRK UP P42685 FRK_HUMAN fructose-bisphosphate aldolase FPLX 000025 ALDO FSH FPLX 000175 FSH FTase FPLX 000172 FNT @@ -1015,12 +1015,12 @@ Fucosyltransferases FPLX 000176 FUT fucosyltransferase FPLX 000176 FUT fucosyltransferases FPLX 000176 FUT FUT FPLX 000176 FUT -Fyn UP FYN_HUMAN P06241 +Fyn UP P06241 FYN_HUMAN Fz FPLX 000177 FZD FZD FPLX 000177 FZD -G 1 GO G1 phase GO:0051318 -G 1 MESH G1 Phase D016193 -G 2 MESH G2 Phase D016195 +G 1 GO GO:0051318 G1 phase +G 1 MESH D016193 G1 Phase +G 2 MESH D016195 G2 Phase G alphai FPLX 000213 G_i_alpha G alphaq FPLX 000216 G_q_alpha G alphaS FPLX 000218 G_s_alpha @@ -1059,10 +1059,10 @@ G12 family FPLX 000207 G_12 G12 proteins FPLX 000207 G_12 G12 FPLX 000207 G_12 GA PUBCHEM 370 . -GA CHEBI gallic acid CHEBI:30778 +GA CHEBI CHEBI:30778 gallic acid Ga12 FPLX 000208 G_12_alpha -Gab1 UP GAB1_HUMAN Q13480 -Gab2 UP GAB2_HUMAN Q9UQC2 +Gab1 UP Q13480 GAB1_HUMAN +Gab2 UP Q9UQC2 GAB2_HUMAN GABA receptor FPLX 000179 GABR GABA receptors FPLX 000179 GABR GABA-A receptor FPLX 000179 GABR @@ -1079,23 +1079,23 @@ gamma-secretase FPLX 000181 Gamma_secretase gamma-tubulin FPLX 000485 TUBG GAP FPLX 000182 GAP Gas6 receptors FPLX 000183 GAS6_receptor -gastrin UP GAST_HUMAN P01350 +gastrin UP P01350 GAST_HUMAN GATA family FPLX 000184 GATA GATA FPLX 000184 GATA Gbeta FPLX 000210 G_beta GCNT FPLX 000185 GCNT -GDF15 UP GDF15_HUMAN Q99988 +GDF15 UP Q99988 GDF15_HUMAN GDP HMDB HMDB01201 . GDP PUBCHEM 135398619 . -GDP CHEBI GDP CHEBI:17552 +GDP CHEBI CHEBI:17552 GDP GEF FPLX 000186 GEF -GEF-H1 UP ARHG2_HUMAN Q92974 +GEF-H1 UP Q92974 ARHG2_HUMAN gefitinib PUBCHEM 123631 . -gefitinib CHEBI gefitinib CHEBI:49668 +gefitinib CHEBI CHEBI:49668 gefitinib GEFs FPLX 000186 GEF general transcription factor II E FPLX 000196 GTF2E general transcription factor II F FPLX 000197 GTF2F -genistein CHEBI genistein CHEBI:28088 +genistein CHEBI CHEBI:28088 genistein genistein PUBCHEM 5280961 . Gi alpha subunit FPLX 000213 G_i_alpha Gi alpha FPLX 000213 G_i_alpha @@ -1115,15 +1115,15 @@ glutamate metabotropic receptors FPLX 000193 GRM glutathione peroxidase FPLX 000190 GPX glutathione S-transferase FPLX 000195 GST glutathione PUBCHEM 124886 . -glutathione CHEBI glutathione CHEBI:16856 +glutathione CHEBI CHEBI:16856 glutathione glutathione HMDB HMDB00125 . Glycogen phosphorylase FPLX 000396 PYG Glycogen phosphorylases FPLX 000396 PYG glycogen phosphorylase FPLX 000396 PYG glycogen phosphorylases FPLX 000396 PYG glycogen synthase FPLX 000206 GYS -glycolysis GO glycolytic process GO:0006096 -glycolysis MESH Glycolysis D006019 +glycolysis GO GO:0006096 glycolytic process +glycolysis MESH D006019 Glycolysis glycoprotein Ib-V-IX complex FPLX 000188 GPIb_IX_V Glycoprotein Ib-V-IX FPLX 000188 GPIb_IX_V Glycoprotein Ib/V/IX FPLX 000188 GPIb_IX_V @@ -1138,9 +1138,9 @@ Glycosyltransferase family 8 FPLX 000201 GTF_family_8 glycosyltransferase family 8 FPLX 000201 GTF_family_8 Glycosyltransferase family 90 FPLX 000203 GTF_family_90 glycosyltransferase family 90 FPLX 000203 GTF_family_90 -gp120 UP ENV_HV1H2 P04578 -gp47 phox UP NCF1_HUMAN P14598 -gp91 phox UP CY24B_HUMAN P04839 +gp120 UP P04578 ENV_HV1H2 +gp47 phox UP P14598 NCF1_HUMAN +gp91 phox UP P04839 CY24B_HUMAN GPCR kinases FPLX 000192 GRK GPCR FPLX 000187 GPCR GPCRs FPLX 000187 GPCR @@ -1155,13 +1155,13 @@ Gq alpha FPLX 000216 G_q_alpha Gq α subunit FPLX 000216 G_q_alpha Gq α FPLX 000216 G_q_alpha Gq/11 FPLX 000215 G_q -GR UP GSHR_HUMAN P00390 -GRB2 UP GRB2_HUMAN P62993 -Grb2 UP GRB2_HUMAN P62993 +GR UP P00390 GSHR_HUMAN +GRB2 UP P62993 GRB2_HUMAN +Grb2 UP P62993 GRB2_HUMAN GRK FPLX 000192 GRK GRKs FPLX 000192 GRK group IV-PLA(2) FPLX 000368 PLA2G4 -GRP78 UP BIP_HUMAN P11021 +GRP78 UP P11021 BIP_HUMAN Gs alpha subunit FPLX 000218 G_s_alpha Gs alpha FPLX 000218 G_s_alpha Gs family FPLX 000217 G_s @@ -1169,23 +1169,23 @@ Gs protein FPLX 000217 G_s Gs α subunit FPLX 000218 G_s_alpha Gs α FPLX 000218 G_s_alpha GSH PUBCHEM 124886 . -GSH CHEBI glutathione CHEBI:16856 +GSH CHEBI CHEBI:16856 glutathione GSH HMDB HMDB00125 . GSK-3 FPLX 000194 GSK3 -GSK-3beta UP GSK3B_HUMAN P49841 -GSK-3β UP GSK3B_HUMAN P49841 +GSK-3beta UP P49841 GSK3B_HUMAN +GSK-3β UP P49841 GSK3B_HUMAN GSK3 FPLX 000194 GSK3 -GSK3beta UP GSK3B_HUMAN P49841 -GSK3β UP GSK3B_HUMAN P49841 +GSK3beta UP P49841 GSK3B_HUMAN +GSK3β UP P49841 GSK3B_HUMAN GST FPLX 000195 GST GSTs FPLX 000195 GST GTP HMDB HMDB01273 . -GTP CHEBI GTP CHEBI:15996 +GTP CHEBI CHEBI:15996 GTP GTP PUBCHEM 135398633 . GTPase FPLX 000204 GTPase GTPase-activating proteins FPLX 000182 GAP guanine PUBCHEM 135398634 . -guanine CHEBI guanine CHEBI:16235 +guanine CHEBI CHEBI:16235 guanine guanylate cyclase FPLX 000205 GUCY guanylyl cyclase FPLX 000205 GUCY G_alpha FPLX 000209 G_alpha @@ -1195,25 +1195,25 @@ Gα12 FPLX 000208 G_12_alpha Gαi FPLX 000213 G_i_alpha Gαq FPLX 000216 G_q_alpha GαS FPLX 000218 G_s_alpha -H-Ras UP RASH_HUMAN P01112 -H/R MESH Cell Hypoxia D015687 -H2AX UP H2AX_HUMAN P16104 +H-Ras UP P01112 RASH_HUMAN +H/R MESH D015687 Cell Hypoxia +H2AX UP P16104 H2AX_HUMAN H2B FPLX 000236 Histone_H2B H3 FPLX 000237 Histone_H3 h9-1-1 complex FPLX 000001 9_1_1 haem oxygenase FPLX 000240 HMOX hAxin FPLX 000062 AXIN -HB-EGF UP HBEGF_HUMAN Q99075 -HBx UP None Q157B2 +HB-EGF UP Q99075 HBEGF_HUMAN +HBx UP Q157B2 None hCG FPLX 000219 hCG -HDAC inhibitor CHEBI EC 3.5.1.98 (histone deacetylase) inhibitor CHEBI:61115 +HDAC inhibitor CHEBI CHEBI:61115 EC 3.5.1.98 (histone deacetylase) inhibitor HDAC FPLX 000220 HDAC -HDAC1 UP HDAC1_HUMAN Q13547 -HDAC2 UP HDAC2_HUMAN Q92769 -HDAC3 UP HDAC3_HUMAN O15379 -HDACi CHEBI EC 3.5.1.98 (histone deacetylase) inhibitor CHEBI:61115 +HDAC1 UP Q13547 HDAC1_HUMAN +HDAC2 UP Q92769 HDAC2_HUMAN +HDAC3 UP O15379 HDAC3_HUMAN +HDACi CHEBI CHEBI:61115 EC 3.5.1.98 (histone deacetylase) inhibitor HDL FPLX 000225 HDL -HDM2 UP MDM2_HUMAN Q00987 +HDM2 UP Q00987 MDM2_HUMAN Heat Shock Protein 70 FPLX 000244 HSPA heat shock protein family B FPLX 000245 HSPB Hedgehog family FPLX 000226 Hedgehog @@ -1222,27 +1222,27 @@ hedgehog signaling proteins FPLX 000226 Hedgehog Hedgehog FPLX 000226 Hedgehog heme oxygenase FPLX 000240 HMOX hemoglobin FPLX 000227 Hemoglobin -HER-2 UP ERBB2_HUMAN P04626 -HER2 receptor UP ERBB2_HUMAN P04626 -HER2 UP ERBB2_HUMAN P04626 -HER3 UP ERBB3_HUMAN P21860 +HER-2 UP P04626 ERBB2_HUMAN +HER2 receptor UP P04626 ERBB2_HUMAN +HER2 UP P04626 ERBB2_HUMAN +HER3 UP P21860 ERBB3_HUMAN Hes gene family FPLX 000228 HES Hes genes FPLX 000228 HES HES FPLX 000228 HES Hes FPLX 000228 HES HG HMDB HMDB00122 . -HGF UP HGF_HUMAN P14210 -Hic-5 UP TGFI1_HUMAN O43294 +HGF UP P14210 HGF_HUMAN +Hic-5 UP O43294 TGFI1_HUMAN HIF FPLX 000229 HIF HIF-1 FPLX 000230 HIF1 -HIF-1alpha protein UP HIF1A_HUMAN Q16665 -HIF-1alpha UP HIF1A_HUMAN Q16665 -HIF-1α protein UP HIF1A_HUMAN Q16665 -HIF-1α UP HIF1A_HUMAN Q16665 -HIF1alpha protein UP HIF1A_HUMAN Q16665 -HIF1alpha UP HIF1A_HUMAN Q16665 -HIF1α protein UP HIF1A_HUMAN Q16665 -HIF1α UP HIF1A_HUMAN Q16665 +HIF-1alpha protein UP Q16665 HIF1A_HUMAN +HIF-1alpha UP Q16665 HIF1A_HUMAN +HIF-1α protein UP Q16665 HIF1A_HUMAN +HIF-1α UP Q16665 HIF1A_HUMAN +HIF1alpha protein UP Q16665 HIF1A_HUMAN +HIF1alpha UP Q16665 HIF1A_HUMAN +HIF1α protein UP Q16665 HIF1A_HUMAN +HIF1α UP Q16665 HIF1A_HUMAN HIFalpha FPLX 000231 HIF_alpha Hifalpha FPLX 000231 HIF_alpha HIFbeta FPLX 000232 HIF_beta @@ -1253,7 +1253,7 @@ Hifα FPLX 000231 HIF_alpha HIFβ FPLX 000232 HIF_beta Hifβ FPLX 000232 HIF_beta High-density lipoproteins FPLX 000225 HDL -HIPK2 UP HIPK2_HUMAN Q9H2X6 +HIPK2 UP Q9H2X6 HIPK2_HUMAN Histone 2A FPLX 000235 Histone_H2A histone deacetylase FPLX 000220 HDAC histone deacetylases FPLX 000220 HDAC @@ -1268,19 +1268,19 @@ histone FPLX 000233 Histone histone-3 FPLX 000237 Histone_H3 histones FPLX 000233 Histone HLA-DR FPLX 000239 HLA_DR -HMGB1 UP HMGB1_HUMAN P09429 -HO-1 UP HMOX1_HUMAN P09601 +HMGB1 UP P09429 HMGB1_HUMAN +HO-1 UP P09601 HMOX1_HUMAN homeodomain iroquois proteins FPLX 000265 IRX HOTAIR HGNC 33510 HOTAIR HOTAIR NONCODE NONHSAT028507.2 . HOTAIR LNCRNADB HOTAIR . -HR GO recombinational repair GO:0000725 -HR MESH Recombinational DNA Repair D059767 -HRAS UP RASH_HUMAN P01112 -HRASV12 UP RASH_HUMAN P01112 -HSF1 UP HSF1_HUMAN Q00613 -HSP20 UP HSPB6_HUMAN O14558 -HSP27 UP HSPB1_HUMAN P04792 +HR GO GO:0000725 recombinational repair +HR MESH D059767 Recombinational DNA Repair +HRAS UP P01112 RASH_HUMAN +HRASV12 UP P01112 RASH_HUMAN +HSF1 UP Q00613 HSF1_HUMAN +HSP20 UP O14558 HSPB6_HUMAN +HSP27 UP P04792 HSPB1_HUMAN HSP70 FPLX 000244 HSPA Hsp70 FPLX 000244 HSPA HSP90 FPLX 000241 HSP90 @@ -1289,78 +1289,78 @@ HSP90A FPLX 000242 HSP90A HSP90AA FPLX 000243 HSP90AA HSPB proteins FPLX 000245 HSPB HSPB FPLX 000245 HSPB -hTERT UP TERT_HUMAN O14746 +hTERT UP O14746 TERT_HUMAN HuR HGNC 3312 ELAVL1 -HuR UP ELAV1_HUMAN Q15717 +HuR UP Q15717 ELAV1_HUMAN hydrogen peroxide PUBCHEM 784 . -hydrogen peroxide CHEBI hydrogen peroxide CHEBI:16240 +hydrogen peroxide CHEBI CHEBI:16240 hydrogen peroxide hypoxia-inducible factors FPLX 000229 HIF -I/R MESH Radiation, Ionizing D011839 -ICAM-1 UP ICAM1_HUMAN P05362 -IER3 UP IEX1_HUMAN P46695 -IFI16 UP IF16_HUMAN Q16666 +I/R MESH D011839 Radiation, Ionizing +ICAM-1 UP P05362 ICAM1_HUMAN +IER3 UP P46695 IEX1_HUMAN +IFI16 UP Q16666 IF16_HUMAN IFN FPLX 000262 Interferon IFN-a FPLX 000246 IFNA IFN-alpha FPLX 000246 IFNA IFN-beta FPLX 000247 IFNB -IFN-beta UP IFNB_HUMAN P01574 -IFN-gamma UP IFNG_HUMAN P01579 +IFN-beta UP P01574 IFNB_HUMAN +IFN-gamma UP P01579 IFNG_HUMAN IFN-α FPLX 000246 IFNA IFN-β FPLX 000247 IFNB -IFN-β UP IFNB_HUMAN P01574 -IFN-γ UP IFNG_HUMAN P01579 +IFN-β UP P01574 IFNB_HUMAN +IFN-γ UP P01579 IFNG_HUMAN IFNalpha FPLX 000246 IFNA -IFNgamma UP IFNG_HUMAN P01579 +IFNgamma UP P01579 IFNG_HUMAN IFNGR FPLX 000263 Interferon_gamma_receptor IFNα FPLX 000246 IFNA -IFNγ UP IFNG_HUMAN P01579 -IGF-1 UP IGF1_HUMAN P05019 -IGF-1R UP IGF1R_HUMAN P08069 -IGF-1Rbeta UP IGF1R_HUMAN P08069 -IGF-1Rβ UP IGF1R_HUMAN P08069 +IFNγ UP P01579 IFNG_HUMAN +IGF-1 UP P05019 IGF1_HUMAN +IGF-1R UP P08069 IGF1R_HUMAN +IGF-1Rbeta UP P08069 IGF1R_HUMAN +IGF-1Rβ UP P08069 IGF1R_HUMAN IGF-BP FPLX 000248 IGFBP -IGF-I UP IGF1_HUMAN P05019 -IGF-IR UP IGF1R_HUMAN P08069 -IGF1 UP IGF1_HUMAN P05019 -IGF1R UP IGF1R_HUMAN P08069 +IGF-I UP P05019 IGF1_HUMAN +IGF-IR UP P08069 IGF1R_HUMAN +IGF1 UP P05019 IGF1_HUMAN +IGF1R UP P08069 IGF1R_HUMAN IGFBP FPLX 000248 IGFBP IGFBPs FPLX 000248 IGFBP IkappaB kinase FPLX 000251 IKK_family IkappaB FPLX 000249 IKB IkappaB-alpha HGNC 7797 NFKBIA -IkappaBalpha UP IKBA_HUMAN P25963 +IkappaBalpha UP P25963 IKBA_HUMAN IKK complex FPLX 000250 IKK_complex IKK FPLX 000251 IKK_family -IKKalpha UP IKKA_HUMAN O15111 -IKKbeta UP IKKB_HUMAN O14920 -IKKβ UP IKKB_HUMAN O14920 -IKKα UP IKKA_HUMAN O15111 +IKKalpha UP O15111 IKKA_HUMAN +IKKbeta UP O14920 IKKB_HUMAN +IKKβ UP O14920 IKKB_HUMAN +IKKα UP O15111 IKKA_HUMAN IL-1 FPLX 000252 IL1 -IL-10 UP IL10_HUMAN P22301 +IL-10 UP P22301 IL10_HUMAN IL-12 FPLX 000253 IL12 IL-15 receptor FPLX 000254 IL15R IL-15R FPLX 000254 IL15R -IL-17 UP IL17_HUMAN Q16552 -IL-18 UP IL18_HUMAN Q14116 -IL-1beta UP IL1B_HUMAN P01584 -IL-1β UP IL1B_HUMAN P01584 +IL-17 UP Q16552 IL17_HUMAN +IL-18 UP Q14116 IL18_HUMAN +IL-1beta UP P01584 IL1B_HUMAN +IL-1β UP P01584 IL1B_HUMAN IL-2 receptor FPLX 000255 IL2R -IL-2 UP IL2_HUMAN P60568 +IL-2 UP P60568 IL2_HUMAN IL-2R FPLX 000255 IL2R -IL-4 UP IL4_HUMAN P05112 -IL-6 UP IL6_HUMAN P05231 -IL-8 UP IL8_HUMAN P10145 +IL-4 UP P05112 IL4_HUMAN +IL-6 UP P05231 IL6_HUMAN +IL-8 UP P10145 IL8_HUMAN IL1 family FPLX 000252 IL1 IL12 FPLX 000253 IL12 imatinib PUBCHEM 5291 . imatinib LINCS 10023-103 . -imatinib CHEBI imatinib CHEBI:45783 -immune response GO immune response GO:0006955 -infiltration MESH Neoplasm Invasiveness D009361 -inflammation GO inflammatory response GO:0006954 -inflammation MESH Inflammation D007249 -inflammatory response GO inflammatory response GO:0006954 -inflammatory response MESH None 0007249 +imatinib CHEBI CHEBI:45783 imatinib +immune response GO GO:0006955 immune response +infiltration MESH D009361 Neoplasm Invasiveness +inflammation GO GO:0006954 inflammatory response +inflammation MESH D007249 Inflammation +inflammatory response GO GO:0006954 inflammatory response +inflammatory response MESH 0007249 None inhibin A FPLX 000257 Inhibin_A inhibin B FPLX 000258 Inhibin_B Inhibin FPLX 000256 Inhibin @@ -1370,15 +1370,15 @@ inhibin-a FPLX 000257 Inhibin_A inhibin-B FPLX 000258 Inhibin_B inhibin-b FPLX 000258 Inhibin_B initiation factor 4E binding proteins FPLX 000154 EIF4EBP -iNOS UP NOS2_HUMAN P35228 +iNOS UP P35228 NOS2_HUMAN insulin family FPLX 000259 INS Insulin receptor family FPLX 000260 INSR insulin receptor family FPLX 000260 INSR insulin receptor substrate FPLX 000264 IRS -insulin receptor UP INSR_HUMAN P06213 +insulin receptor UP P06213 INSR_HUMAN insulin receptor/insulin-like growth factor receptor family FPLX 000260 INSR -Insulin UP INS_HUMAN P01308 -insulin UP INS_HUMAN P01308 +Insulin UP P01308 INS_HUMAN +insulin UP P01308 INS_HUMAN insulin-like growth factor binding proteins FPLX 000248 IGFBP integrin FPLX 000261 Integrins integrins FPLX 000261 Integrins @@ -1391,61 +1391,61 @@ interferon β FPLX 000247 IFNB interferon FPLX 000262 Interferon interferon-gamma receptor FPLX 000263 Interferon_gamma_receptor interferon-γ receptor FPLX 000263 Interferon_gamma_receptor -invasion MESH Neoplasm Invasiveness D009361 -invasiveness MESH Neoplasm Invasiveness D009361 -IQGAP1 UP IQGA1_HUMAN P46940 -IR MESH Radiation, Ionizing D011839 -IR UP INSR_HUMAN P06213 -IRF3 UP IRF3_HUMAN Q14653 +invasion MESH D009361 Neoplasm Invasiveness +invasiveness MESH D009361 Neoplasm Invasiveness +IQGAP1 UP P46940 IQGA1_HUMAN +IR MESH D011839 Radiation, Ionizing +IR UP P06213 INSR_HUMAN +IRF3 UP Q14653 IRF3_HUMAN iron PUBCHEM 23925 . -iron CHEBI iron atom CHEBI:18248 +iron CHEBI CHEBI:18248 iron atom Iroquois family FPLX 000265 IRX Iroquois proteins FPLX 000265 IRX Iroquois-class homeodomain proteins FPLX 000265 IRX IRS family FPLX 000264 IRS IRS FPLX 000264 IRS -IRS-1 UP IRS1_HUMAN P35568 -IRS-2 UP IRS2_HUMAN Q9Y4H2 -IRS1 UP IRS1_HUMAN P35568 -IRS2 UP IRS2_HUMAN Q9Y4H2 +IRS-1 UP P35568 IRS1_HUMAN +IRS-2 UP Q9Y4H2 IRS2_HUMAN +IRS1 UP P35568 IRS1_HUMAN +IRS2 UP Q9Y4H2 IRS2_HUMAN isoflurane PUBCHEM 3763 . -isoflurane CHEBI isoflurane CHEBI:6015 +isoflurane CHEBI CHEBI:6015 isoflurane IκB kinase FPLX 000251 IKK_family IκB FPLX 000249 IKB IκB-α HGNC 7797 NFKBIA -IκBα UP IKBA_HUMAN P25963 +IκBα UP P25963 IKBA_HUMAN JAK FPLX 000266 JAK Jak FPLX 000266 JAK -JAK2 UP JAK2_HUMAN O60674 +JAK2 UP O60674 JAK2_HUMAN JAKs FPLX 000266 JAK JNK MAPK FPLX 000267 JNK JNK FPLX 000267 JNK -JNK1 UP MK08_HUMAN P45983 +JNK1 UP P45983 MK08_HUMAN JNK1/2 FPLX 000267 JNK JNKs FPLX 000267 JNK JQ1 PUBCHEM 46907787 . -JQ1 CHEBI LSM-6332 CHEBI:95080 +JQ1 CHEBI CHEBI:95080 LSM-6332 JUN FPLX 000268 JUN_family -K-Ras UP RASK_HUMAN P01116 +K-Ras UP P01116 RASK_HUMAN Kainate receptors FPLX 000269 Kainate_family kallikrein FPLX 000271 KLK kallikrein-related peptidases FPLX 000271 KLK KARs FPLX 000269 Kainate_family -Keap1 UP KEAP1_HUMAN Q14145 +Keap1 UP Q14145 KEAP1_HUMAN kinetochore centromere binding factor 3 FPLX 000084 CBF3 kinetochore complex FPLX 000270 Kinetochore kinetochore FPLX 000270 Kinetochore kinetochores FPLX 000270 Kinetochore -KLF5 UP KLF5_HUMAN Q13887 -Klf5 UP KLF5_HUMAN Q13887 +KLF5 UP Q13887 KLF5_HUMAN +Klf5 UP Q13887 KLF5_HUMAN KLKs FPLX 000271 KLK -KRAS UP RASK_HUMAN P01116 -Kras UP RASK_HUMAN P01116 +KRAS UP P01116 RASK_HUMAN +Kras UP P01116 RASK_HUMAN KSR FPLX 000272 KSR -LA CHEBI (R)-lipoic acid CHEBI:30314 +LA CHEBI CHEBI:30314 (R)-lipoic acid LA PUBCHEM 6112 . lactate PUBCHEM 91435 . -lactate CHEBI lactate CHEBI:24996 +lactate CHEBI CHEBI:24996 lactate laminin 332 chains FPLX 000274 Laminin_332 laminin 332 FPLX 000274 Laminin_332 laminin-332 chains FPLX 000274 Laminin_332 @@ -1453,123 +1453,123 @@ laminin-332 FPLX 000274 Laminin_332 Laminin-5 FPLX 000274 Laminin_332 laminin-5 FPLX 000274 Laminin_332 lapatinib PUBCHEM 208908 . -lapatinib CHEBI lapatinib CHEBI:49603 -LAT UP LAT_HUMAN O43561 +lapatinib CHEBI CHEBI:49603 lapatinib +LAT UP O43561 LAT_HUMAN LC3 FPLX 000280 MAP1LC3 -Lck UP LCK_HUMAN P06239 +Lck UP P06239 LCK_HUMAN LDH FPLX 000275 LDH lead PUBCHEM 5352425 . -lead CHEBI lead atom CHEBI:25016 -leptin UP LEP_HUMAN P41159 +lead CHEBI CHEBI:25016 lead atom +leptin UP P41159 LEP_HUMAN LFA-1 (integrin) FPLX 000261 Integrins LH FPLX 000276 LH -LIF UP LIF_HUMAN P15018 -lipopolysaccharide CHEBI lipopolysaccharide CHEBI:16412 -lipopolysaccharide MESH Lipopolysaccharides D008070 -LKB1 UP STK11_HUMAN Q15831 +LIF UP P15018 LIF_HUMAN +lipopolysaccharide CHEBI CHEBI:16412 lipopolysaccharide +lipopolysaccharide MESH D008070 Lipopolysaccharides +LKB1 UP Q15831 STK11_HUMAN LM-1 FPLX 000273 Laminin_111 -LMP1 UP LMP1_EBVB9 P03230 -localization GO localization GO:0051179 +LMP1 UP P03230 LMP1_EBVB9 +localization GO GO:0051179 localization long-chain acyl-CoA synthetase FPLX 000008 ACSL -LPA UP APOA_HUMAN P08519 -LPS CHEBI lipopolysaccharide CHEBI:16412 -LPS MESH Lipopolysaccharides D008070 -LRRK2 UP LRRK2_HUMAN Q5S007 +LPA UP P08519 APOA_HUMAN +LPS CHEBI CHEBI:16412 lipopolysaccharide +LPS MESH D008070 Lipopolysaccharides +LRRK2 UP Q5S007 LRRK2_HUMAN Luteinizing hormone FPLX 000276 LH luteinizing hormone FPLX 000276 LH luteinizing-hormone FPLX 000276 LH luteolin PUBCHEM 5280445 . -luteolin CHEBI luteolin CHEBI:15864 +luteolin CHEBI CHEBI:15864 luteolin MA PUBCHEM 10836 . -MA CHEBI methamphetamine CHEBI:6809 +MA CHEBI CHEBI:6809 methamphetamine MA PUBCHEM 73659 . -MA CHEBI maslinic acid CHEBI:66682 -MA UP GAG_HV1H2 P04591 +MA CHEBI CHEBI:66682 maslinic acid +MA UP P04591 GAG_HV1H2 MAC FPLX 000278 MAC MAC-1 (integrin) FPLX 000261 Integrins -Mad2 UP MD2L1_HUMAN Q13257 +Mad2 UP Q13257 MD2L1_HUMAN Maf subfamily FPLX 000279 MAF MAF FPLX 000279 MAF Maf FPLX 000279 MAF maf FPLX 000279 MAF -MAF UP MAF_HUMAN O75444 -Maf UP MAF_HUMAN O75444 -maf UP MAF_HUMAN O75444 -mammalian target of rapamycin UP MTOR_HUMAN P42345 -mangiferin CHEBI mangiferin CHEBI:6682 +MAF UP O75444 MAF_HUMAN +Maf UP O75444 MAF_HUMAN +maf UP O75444 MAF_HUMAN +mammalian target of rapamycin UP P42345 MTOR_HUMAN +mangiferin CHEBI CHEBI:6682 mangiferin mangiferin PUBCHEM 5281647 . MAP kinase FPLX 000283 MAPK MAP kinases FPLX 000283 MAPK -MAP2K1 UP MP2K1_HUMAN Q02750 -MAP2K2 UP MP2K2_HUMAN P36507 +MAP2K1 UP Q02750 MP2K1_HUMAN +MAP2K2 UP P36507 MP2K2_HUMAN MAP3K FPLX 000282 MAP3K -MAP3K2 UP M3K2_HUMAN Q9Y2U5 +MAP3K2 UP Q9Y2U5 M3K2_HUMAN MAPK kinase kinase FPLX 000282 MAP3K MAPK kinase FPLX 000281 MAP2K MAPK p38 FPLX 000326 p38 MAPK FPLX 000161 ERK -MAPK1 UP MK01_HUMAN P28482 -MAPK3 UP MK03_HUMAN P27361 +MAPK1 UP P28482 MK01_HUMAN +MAPK3 UP P27361 MK03_HUMAN MAPKK kinases FPLX 000282 MAP3K MAPKKK FPLX 000282 MAP3K MAPKs FPLX 000283 MAPK -MAZ UP MAZ_HUMAN P56270 -Mcl-1 UP MCL1_HUMAN Q07820 +MAZ UP P56270 MAZ_HUMAN +Mcl-1 UP Q07820 MCL1_HUMAN MCM FPLX 000284 MCM -MCP-1 UP None P0CW71 -MDM2 UP MDM2_HUMAN Q00987 -Mdm2 UP MDM2_HUMAN Q00987 -MDMX UP MDM4_HUMAN O15151 -Mdmx UP MDM4_HUMAN O15151 -MED14 UP MED14_HUMAN O60244 -MED23 UP MED23_HUMAN Q9ULK4 +MCP-1 UP P0CW71 None +MDM2 UP Q00987 MDM2_HUMAN +Mdm2 UP Q00987 MDM2_HUMAN +MDMX UP O15151 MDM4_HUMAN +Mdmx UP O15151 MDM4_HUMAN +MED14 UP O60244 MED14_HUMAN +MED23 UP Q9ULK4 MED23_HUMAN MEF2 family FPLX 000285 MEF2 MEF2 FPLX 000285 MEF2 -MEF2C UP MEF2C_HUMAN Q06413 +MEF2C UP Q06413 MEF2C_HUMAN MEK 1/2 FPLX 000286 MEK -MEK inhibitor CHEBI EC 2.7.12.2 (mitogen-activated protein kinase kinase) inhibitor CHEBI:88286 -MEK inhibitors CHEBI EC 2.7.12.2 (mitogen-activated protein kinase kinase) inhibitor CHEBI:88286 +MEK inhibitor CHEBI CHEBI:88286 EC 2.7.12.2 (mitogen-activated protein kinase kinase) inhibitor +MEK inhibitors CHEBI CHEBI:88286 EC 2.7.12.2 (mitogen-activated protein kinase kinase) inhibitor MEK FPLX 000286 MEK -MEK1 UP MP2K1_HUMAN Q02750 +MEK1 UP Q02750 MP2K1_HUMAN MEK1/2 FPLX 000286 MEK melanin PUBCHEM 6325610 . -melanin CHEBI Melanin CHEBI:89634 -melatonin CHEBI melatonin CHEBI:16796 +melanin CHEBI CHEBI:89634 Melanin +melatonin CHEBI CHEBI:16796 melatonin melatonin PUBCHEM 896 . membrane attack complex FPLX 000278 MAC membrane attack FPLX 000278 MAC -MET UP MET_HUMAN P08581 -Met UP MET_HUMAN P08581 -metabolism GO metabolic process GO:0008152 -metabolism MESH Metabolism D008660 +MET UP P08581 MET_HUMAN +Met UP P08581 MET_HUMAN +metabolism GO GO:0008152 metabolic process +metabolism MESH D008660 Metabolism metabotrophic glutamate receptor FPLX 000193 GRM metabotropic glutamate receptor FPLX 000193 GRM -metastasis MESH Neoplasm Metastasis D009362 +metastasis MESH D009362 Neoplasm Metastasis Metformin PUBCHEM 4091 . -Metformin CHEBI metformin CHEBI:6801 +Metformin CHEBI CHEBI:6801 metformin metformin PUBCHEM 4091 . -metformin CHEBI metformin CHEBI:6801 +metformin CHEBI CHEBI:6801 metformin Metallothionein FPLX 000292 Metallothionein metallothionein FPLX 000292 Metallothionein MG132 PUBCHEM 462382 . -MG132 CHEBI N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal CHEBI:75142 +MG132 CHEBI CHEBI:75142 N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal mGluRs FPLX 000193 GRM -MIF UP MIF_HUMAN P14174 +MIF UP P14174 MIF_HUMAN mini-chromosome maintenance complex FPLX 000284 MCM minichromosome maintenance complex FPLX 000284 MCM minichromosome maintenance protein complex FPLX 000284 MCM -miR-101 MESH MIRN101 microRNA, human C534072 -miR-101 MIRBASE hsa-mir-101-1 MI0000103 +miR-101 MESH C534072 MIRN101 microRNA, human +miR-101 MIRBASE MI0000103 hsa-mir-101-1 miR-101 HGNC 31488 MIR101-1 -miR-145 MIRBASE hsa-mir-145 MI0000461 +miR-145 MIRBASE MI0000461 hsa-mir-145 miR-145 HGNC 31532 MIR145 -miR-155 MIRBASE hsa-mir-155 MI0000681 +miR-155 MIRBASE MI0000681 hsa-mir-155 miR-155 HGNC 31542 MIR155 -miR-21 MIRBASE hsa-mir-21 MI0000077 +miR-21 MIRBASE MI0000077 hsa-mir-21 miR-21 HGNC 31586 MIR21 -miR-7 MIRBASE hsa-mir-7-1 MI0000263 +miR-7 MIRBASE MI0000263 hsa-mir-7-1 miR-7 HGNC 31638 MIR7-1 -MITF UP MITF_HUMAN O75030 +MITF UP O75030 MITF_HUMAN mammalian mitochondrial ribosome FPLX 000288 Mitochondrial_Ribosome Mitochondrial ribosome FPLX 000288 Mitochondrial_Ribosome Mitochondrial Ribosome FPLX 000288 Mitochondrial_Ribosome @@ -1592,42 +1592,42 @@ Large Mitoribosomal Subunit FPLX 000290 MRPL large subunit of the mammalian mitochondrial ribosome FPLX 000290 MRPL MGAT FPLX 000287 MGAT mitochondrial ribosomal large subunit FPLX 000290 MRPL -mitochondrial membrane potential MESH Membrane Potential, Mitochondrial D053078 +mitochondrial membrane potential MESH D053078 Membrane Potential, Mitochondrial mitogen activated protein kinase FPLX 000283 MAPK mitogen activated protein kinases FPLX 000283 MAPK mitogen-activated protein kinase kinase FPLX 000281 MAP2K mitogen-activated protein kinase FPLX 000283 MAPK mitogen-activated protein kinases FPLX 000283 MAPK -Miz1 UP ZBT17_HUMAN Q13105 -MKK4 UP MP2K4_HUMAN P45985 -MKP-1 UP DUS1_HUMAN P28562 -MKP3 UP DUS6_HUMAN Q16828 +Miz1 UP Q13105 ZBT17_HUMAN +MKK4 UP P45985 MP2K4_HUMAN +MKP-1 UP P28562 DUS1_HUMAN +MKP3 UP Q16828 DUS6_HUMAN MLC FPLX 000296 MYL -MM MESH Multiple Myeloma D009101 +MM MESH D009101 Multiple Myeloma MMC PUBCHEM 5746 . -MMC CHEBI mitomycin C CHEBI:27504 +MMC CHEBI CHEBI:27504 mitomycin C MMP FPLX 000291 MMP -MMP-2 UP MMP2_HUMAN P08253 -MMP-9 UP MMP9_HUMAN P14780 -MMP9 UP MMP9_HUMAN P14780 +MMP-2 UP P08253 MMP2_HUMAN +MMP-9 UP P14780 MMP9_HUMAN +MMP9 UP P14780 MMP9_HUMAN MMPs FPLX 000291 MMP -Mn CHEBI manganese(2+) CHEBI:29035 +Mn CHEBI CHEBI:29035 manganese(2+) Mn PUBCHEM 27854 . -MST1 UP STK4_HUMAN Q13043 -MST2 UP STK3_HUMAN Q13188 +MST1 UP Q13043 STK4_HUMAN +MST2 UP Q13188 STK3_HUMAN MT FPLX 000292 Metallothionein -mTOR inhibitor CHEBI mTOR inhibitor CHEBI:68481 -mTOR inhibitors CHEBI mTOR inhibitor CHEBI:68481 -mTOR UP MTOR_HUMAN P42345 +mTOR inhibitor CHEBI CHEBI:68481 mTOR inhibitor +mTOR inhibitors CHEBI CHEBI:68481 mTOR inhibitor +mTOR UP P42345 MTOR_HUMAN mTORC1 FPLX 000293 mTORC1 mTORC2 FPLX 000294 mTORC2 -MTX UP MTX1_HUMAN Q13505 +MTX UP Q13505 MTX1_HUMAN Mu-A PUBCHEM 375150 . -MUC1 UP MUC1_HUMAN P15941 -mutp53 UP P53_HUMAN P04637 -MYC UP MYC_HUMAN P01106 -Myc UP MYC_HUMAN P01106 -MYCN UP MYCN_HUMAN P04198 +MUC1 UP P15941 MUC1_HUMAN +mutp53 UP P04637 P53_HUMAN +MYC UP P01106 MYC_HUMAN +Myc UP P01106 MYC_HUMAN +MYCN UP P04198 MYCN_HUMAN myosin alkali light chain proteins FPLX 000297 MYL_alkali myosin alkali light chain FPLX 000297 MYL_alkali myosin heavy chain genes FPLX 000295 MYH @@ -1640,21 +1640,21 @@ myosin heavy chains FPLX 000295 MYH myosin light chain protein FPLX 000296 MYL myosin light chain FPLX 000296 MYL myosin light chains FPLX 000296 MYL -MYPT1 UP MYPT1_HUMAN O14974 +MYPT1 UP O14974 MYPT1_HUMAN MYST family FPLX 000300 MYST MYST histone acetylase FPLX 000300 MYST MYST proteins FPLX 000300 MYST -N-cadherin UP CADH2_HUMAN P19022 +N-cadherin UP P19022 CADH2_HUMAN N-myc downstream regulated gene family FPLX 000307 NDRG -N-Myc UP MYCN_HUMAN P04198 -N-Ras UP RASN_HUMAN P01111 +N-Myc UP P04198 MYCN_HUMAN +N-Ras UP P01111 RASN_HUMAN Na+/K+-exchanging ATPase FPLX 000303 Na_K_ATPase Na+/K+ATPase FPLX 000303 Na_K_ATPase Na/K ATPase alpha FPLX 000057 ATP1A Na/K ATPase α FPLX 000057 ATP1A Na/K-ATPase FPLX 000303 Na_K_ATPase NAC PUBCHEM 443227 . -NAC CHEBI NAC CHEBI:7421 +NAC CHEBI CHEBI:7421 NAC nAChR FPLX 000103 CHRN NAD(P)H oxidase FPLX 000302 NADPH_oxidase NAD(P)H-oxidase FPLX 000302 NADPH_oxidase @@ -1662,10 +1662,10 @@ NADH dehydrogenase (ubiquinone) FPLX 000301 NADH_dehydrogenase NADH dehydrogenase FPLX 000301 NADH_dehydrogenase NADPH oxidase FPLX 000302 NADPH_oxidase NADPH PUBCHEM 5884 . -NADPH CHEBI NADPH CHEBI:16474 +NADPH CHEBI CHEBI:16474 NADPH NADPH HMDB HMDB00221 . naked cuticle FPLX 000315 NKD -NAP UP BASP1_HUMAN P80723 +NAP UP P80723 BASP1_HUMAN Natriuretic Peptide FPLX 000304 Natriuretic_peptide Natriuretic peptide FPLX 000304 Natriuretic_peptide natriuretic peptide FPLX 000304 Natriuretic_peptide @@ -1674,15 +1674,15 @@ Natriuretic peptides FPLX 000304 Natriuretic_peptide natriuretic peptides FPLX 000304 Natriuretic_peptide NDR family FPLX 000307 NDRG NDR-family FPLX 000307 NDRG -NDRG2 UP NDRG2_HUMAN Q9UN36 -necroptosis GO necroptotic process GO:0070266 -necrosis GO necrotic cell death GO:0070265 -necrosis MESH Necrosis D009336 -Nef UP NEF_HV1BR P03406 -NEMO UP NEMO_HUMAN Q9Y6K9 -neovascularization GO angiogenesis GO:0001525 -neovascularization MESH Neovascularization, Physiologic D018919 -Net1 UP ARHG8_HUMAN Q7Z628 +NDRG2 UP Q9UN36 NDRG2_HUMAN +necroptosis GO GO:0070266 necroptotic process +necrosis GO GO:0070265 necrotic cell death +necrosis MESH D009336 Necrosis +Nef UP P03406 NEF_HV1BR +NEMO UP Q9Y6K9 NEMO_HUMAN +neovascularization GO GO:0001525 angiogenesis +neovascularization MESH D018919 Neovascularization, Physiologic +Net1 UP Q7Z628 ARHG8_HUMAN neuregulin family FPLX 000318 NRG Neuregulin FPLX 000318 NRG neuregulin FPLX 000318 NRG @@ -1706,7 +1706,7 @@ NF-kappaB factors FPLX 000311 NFkappaB NF-kappaB genes FPLX 000311 NFkappaB NF-kappaB p50 HGNC 7794 NFKB1 NF-kappaB p65 HGNC 9955 RELA -NF-kappaB p65 UP TF65_HUMAN Q04206 +NF-kappaB p65 UP Q04206 TF65_HUMAN NF-kappaB subunits FPLX 000311 NFkappaB NF-kappaB TFs FPLX 000311 NFkappaB NF-kappaB FPLX 000311 NFkappaB @@ -1733,7 +1733,7 @@ NF-κB factors FPLX 000311 NFkappaB NF-κB genes FPLX 000311 NFkappaB NF-κB p50 HGNC 7794 NFKB1 NF-κB p65 HGNC 9955 RELA -NF-κB p65 UP TF65_HUMAN Q04206 +NF-κB p65 UP Q04206 TF65_HUMAN NF-κB subunits FPLX 000311 NFkappaB NF-κB TFs FPLX 000311 NFkappaB NF-κB FPLX 000311 NFkappaB @@ -1755,37 +1755,37 @@ NFκB p50 HGNC 7794 NFKB1 NFκB p65 HGNC 9955 RELA NFκB FPLX 000311 NFkappaB NFκBp65 HGNC 9955 RELA -NGF UP NGF_HUMAN P01138 +NGF UP P01138 NGF_HUMAN nicotine class acetylcholine receptors FPLX 000103 CHRN nicotinic acetylcholine receptor FPLX 000103 CHRN nitric oxide PUBCHEM 145068 . -nitric oxide CHEBI nitric oxide CHEBI:16480 -nmMLCK UP MYLK_HUMAN Q15746-1 -nmMLCK1 UP MYLK_HUMAN Q15746-1 +nitric oxide CHEBI CHEBI:16480 nitric oxide +nmMLCK UP Q15746-1 MYLK_HUMAN +nmMLCK1 UP Q15746-1 MYLK_HUMAN NO HMDB HMDB03378 . -NO CHEBI nitric oxide CHEBI:16480 +NO CHEBI CHEBI:16480 nitric oxide NO PUBCHEM 145068 . non-ELR-CXC chemokines FPLX 000128 CXCL_ELR_negative NOS FPLX 000316 NOS Notch FPLX 000317 Notch -Notch1 UP NOTC1_HUMAN P46531 -NOX1 UP NOX1_HUMAN Q9Y5S8 -NOX2 UP CY24B_HUMAN P04839 -NOX3 UP NOX3_HUMAN Q9HBY0 -NOX4 UP NOX4_HUMAN Q9NPH5 -Noxa UP APR_HUMAN Q13794 -NPM UP NPM_HUMAN P06748 -NRAS UP RASN_HUMAN P01111 -NRF2 UP NF2L2_HUMAN Q16236 -Nrf2 UP NF2L2_HUMAN Q16236 -NRG1 UP NRG1_HUMAN Q02297 +Notch1 UP P46531 NOTC1_HUMAN +NOX1 UP Q9Y5S8 NOX1_HUMAN +NOX2 UP P04839 CY24B_HUMAN +NOX3 UP Q9HBY0 NOX3_HUMAN +NOX4 UP Q9NPH5 NOX4_HUMAN +Noxa UP Q13794 APR_HUMAN +NPM UP P06748 NPM_HUMAN +NRAS UP P01111 RASN_HUMAN +NRF2 UP Q16236 NF2L2_HUMAN +Nrf2 UP Q16236 NF2L2_HUMAN +NRG1 UP Q02297 NRG1_HUMAN NRG1-NRG2 FPLX 000319 NRG_1_2 NRG1/2 FPLX 000319 NRG_1_2 NRG3-NRG4 FPLX 000320 NRG_3_4 NRG3/4 FPLX 000320 NRG_3_4 NRGs FPLX 000318 NRG NRXN FPLX 000308 Neurexins -NTF3 UP NTF3_HUMAN P20783 +NTF3 UP P20783 NTF3_HUMAN NTRK FPLX 000321 NTRK NTRKs FPLX 000321 NTRK Nuclear factor erythroid 2-related factor FPLX 000310 NFE @@ -1796,106 +1796,106 @@ nuclear receptor co-repressor FPLX 000306 NCOR Nuclear receptor corepressor FPLX 000306 NCOR nuclear receptor corepressor FPLX 000306 NCOR Nutlin-3 PUBCHEM 16755649 . -Nutlin-3 CHEBI Nutlin-3 CHEBI:46742 +Nutlin-3 CHEBI CHEBI:46742 Nutlin-3 NVP-BEZ235 PUBCHEM 11977753 . NVP-BEZ235 LINCS 10232-101 . -NVP-BEZ235 CHEBI dactolisib CHEBI:71952 +NVP-BEZ235 CHEBI CHEBI:71952 dactolisib NVP-LDE-225 PUBCHEM 24775005 . -NVP-LDE-225 CHEBI sonidegib CHEBI:90863 -OA CHEBI oleanolic acid CHEBI:37659 +NVP-LDE-225 CHEBI CHEBI:90863 sonidegib +OA CHEBI CHEBI:37659 oleanolic acid OA PUBCHEM 10494 . -OA CHEBI okadaic acid CHEBI:44658 +OA CHEBI CHEBI:44658 okadaic acid OA PUBCHEM 446512 . ofalpha(2)-adrenoceptor FPLX 000020 ADRA2 ofα(2)-adrenoceptor FPLX 000020 ADRA2 -OPG UP TR11B_HUMAN O00300 -OPN UP OSTP_HUMAN P10451 +OPG UP O00300 TR11B_HUMAN +OPN UP P10451 OSTP_HUMAN ov-serpins FPLX 000431 SERPINB -oxaliplatin CHEBI oxaliplatin CHEBI:31941 +oxaliplatin CHEBI CHEBI:31941 oxaliplatin oxaliplatin PUBCHEM 6857599 . oxygen HMDB HMDB01377 . -oxygen CHEBI dioxygen CHEBI:15379 +oxygen CHEBI CHEBI:15379 dioxygen oxygen PUBCHEM 977 . -P-REX1 UP PREX1_HUMAN Q8TCU6 +P-REX1 UP Q8TCU6 PREX1_HUMAN p100 HGNC 7795 NFKB2 p105 HGNC 7794 NFKB1 p110 FPLX 000359 PI3K_p110 -p110alpha UP PK3CA_HUMAN P42336 -p110beta UP PK3CB_HUMAN P42338 -p110α UP PK3CA_HUMAN P42336 -p110β UP PK3CB_HUMAN P42338 -p120 UP CTND1_HUMAN O60716 -p130 UP BCAR1_HUMAN P56945 -p16 UP CDN2A_HUMAN P42771 +p110alpha UP P42336 PK3CA_HUMAN +p110beta UP P42338 PK3CB_HUMAN +p110α UP P42336 PK3CA_HUMAN +p110β UP P42338 PK3CB_HUMAN +p120 UP O60716 CTND1_HUMAN +p130 UP P56945 BCAR1_HUMAN +p16 UP P42771 CDN2A_HUMAN p160/SRC FPLX 000305 NCOA -p21 Cip1 UP CDN1A_HUMAN P38936 -p21 WAF1 UP CDN1A_HUMAN P38936 -p21 UP CDN1A_HUMAN P38936 -p22 phox UP CY24A_HUMAN P13498 -p27 Kip1 UP CDN1B_HUMAN P46527 -p27 UP CDN1B_HUMAN P46527 +p21 Cip1 UP P38936 CDN1A_HUMAN +p21 WAF1 UP P38936 CDN1A_HUMAN +p21 UP P38936 CDN1A_HUMAN +p22 phox UP P13498 CY24A_HUMAN +p27 Kip1 UP P46527 CDN1B_HUMAN +p27 UP P46527 CDN1B_HUMAN P2X purinoreceptor FPLX 000324 P2RX P2X purinoreceptors FPLX 000324 P2RX P2X receptor FPLX 000324 P2RX P2X receptors FPLX 000324 P2RX P2X FPLX 000324 P2RX P2Y receptor FPLX 000325 P2RY -p300 UP EP300_HUMAN Q09472 +p300 UP Q09472 EP300_HUMAN P38 MAPK FPLX 000326 p38 p38 MAPK FPLX 000326 p38 p38 MAPKs FPLX 000326 p38 p38 FPLX 000326 p38 p38-MAPK FPLX 000326 p38 p38MAPK FPLX 000326 p38 -p40 phox UP NCF4_HUMAN Q15080 -p42 UP MK01_HUMAN P28482 -p42 UP PA2G4_HUMAN Q9UQ80 -p47 phox UP NCF1_HUMAN P14598 -p50 UP NFKB1_HUMAN P19838 +p40 phox UP Q15080 NCF4_HUMAN +p42 UP P28482 MK01_HUMAN +p42 UP Q9UQ80 PA2G4_HUMAN +p47 phox UP P14598 NCF1_HUMAN +p50 UP P19838 NFKB1_HUMAN p52 HGNC 7795 NFKB2 P53 family FPLX 000327 p53_family p53 Family FPLX 000327 p53_family p53 family FPLX 000327 p53_family -P53 UP P53_HUMAN P04637 -p53 UP P53_HUMAN P04637 +P53 UP P04637 P53_HUMAN +p53 UP P04637 P53_HUMAN p53/p63/p73 family FPLX 000327 p53_family -p62 UP SQSTM_HUMAN Q13501 -p63 UP P63_HUMAN Q9H3D4 -p65 UP TF65_HUMAN Q04206 -p66Shc UP SHC1_HUMAN P29353-1 -p67 phox UP NCF2_HUMAN P19878 +p62 UP Q13501 SQSTM_HUMAN +p63 UP Q9H3D4 P63_HUMAN +p65 UP Q04206 TF65_HUMAN +p66Shc UP P29353-1 SHC1_HUMAN +p67 phox UP P19878 NCF2_HUMAN p70 S6 kinase FPLX 000328 P70S6K -p70 UP KS6B1_HUMAN P23443 +p70 UP P23443 KS6B1_HUMAN P70RSK FPLX 000328 P70S6K p70RSK FPLX 000328 P70S6K -p70S6 kinase UP KS6B1_HUMAN P23443 +p70S6 kinase UP P23443 KS6B1_HUMAN P70S6K FPLX 000328 P70S6K -p70S6K UP KS6B1_HUMAN P23443 -p73 UP P73_HUMAN O15350 +p70S6K UP P23443 KS6B1_HUMAN +p73 UP O15350 P73_HUMAN p85 FPLX 000360 PI3K_p85 -p85alpha UP P85A_HUMAN P27986 -p85α UP P85A_HUMAN P27986 +p85alpha UP P27986 P85A_HUMAN +p85α UP P27986 P85A_HUMAN p90RSK FPLX 000329 P90RSK -PA CHEBI phosphatidic acid CHEBI:16337 +PA CHEBI CHEBI:16337 phosphatidic acid PA PUBCHEM 8144759 . -paeoniflorin CHEBI paeoniflorin CHEBI:7889 +paeoniflorin CHEBI CHEBI:7889 paeoniflorin paeoniflorin PUBCHEM 442534 . -PAI-1 UP PAI1_HUMAN P05121 +PAI-1 UP P05121 PAI1_HUMAN PAK FPLX 000330 PAK Pak FPLX 000330 PAK -PAK1 UP PAK1_HUMAN Q13153 -Pak1 UP PAK1_HUMAN Q13153 -Pak2 UP PAK2_HUMAN Q13177 -PAK4 UP PAK4_HUMAN O96013 +PAK1 UP Q13153 PAK1_HUMAN +Pak1 UP Q13153 PAK1_HUMAN +Pak2 UP Q13177 PAK2_HUMAN +PAK4 UP O96013 PAK4_HUMAN palmitate PUBCHEM 985 . -palmitate CHEBI hexadecanoic acid CHEBI:15756 +palmitate CHEBI CHEBI:15756 hexadecanoic acid palmitate HMDB HMDB00220 . -PAR3 UP PARD3_HUMAN Q8TEW0 -Parkin UP PRKN_HUMAN O60260 +PAR3 UP Q8TEW0 PARD3_HUMAN +Parkin UP O60260 PRKN_HUMAN PARP genes FPLX 000331 PARP -PARP UP PARP1_HUMAN P09874 -Parp UP PARP1_HUMAN P09874 -PARP-1 UP PARP1_HUMAN P09874 +PARP UP P09874 PARP1_HUMAN +Parp UP P09874 PARP1_HUMAN +PARP-1 UP P09874 PARP1_HUMAN PARPs FPLX 000331 PARP Parvin FPLX 000332 PARV parvin FPLX 000332 PARV @@ -1903,16 +1903,16 @@ Parvins FPLX 000332 PARV parvins FPLX 000332 PARV PATCHED FPLX 000333 Patched Patched FPLX 000333 Patched -paxillin UP PAXI_HUMAN P49023 +paxillin UP P49023 PAXI_HUMAN PBX FPLX 000334 PBX Pbx FPLX 000334 PBX pbx FPLX 000334 PBX PBXs FPLX 000334 PBX -Pca MESH Prostatic Neoplasms D011471 -PCNA UP PCNA_HUMAN P12004 -PD MESH Parkinson Disease D010300 +Pca MESH D011471 Prostatic Neoplasms +PCNA UP P12004 PCNA_HUMAN +PD MESH D010300 Parkinson Disease PD-1 HGNC 8760 PDCD1 -PD98509 CHEBI EC 2.7.11.24 (mitogen-activated protein kinase) inhibitor CHEBI:79091 +PD98509 CHEBI CHEBI:79091 EC 2.7.11.24 (mitogen-activated protein kinase) inhibitor PDE 2 HGNC 8777 PDE2A PDE 3 FPLX 000337 PDE3 PDE FPLX 000335 PDE @@ -1955,25 +1955,25 @@ PDGFR-betabeta FPLX 000346 PDGFR_BB PDGFR-αα FPLX 000344 PDGFR_AA PDGFR-αβ FPLX 000345 PDGFR_AB PDGFR-ββ FPLX 000346 PDGFR_BB -PDGFRalpha UP PGFRA_HUMAN P16234 +PDGFRalpha UP P16234 PGFRA_HUMAN PDGFRalphaalpha FPLX 000344 PDGFR_AA PDGFRalphabeta FPLX 000345 PDGFR_AB -PDGFRbeta UP PGFRB_HUMAN P09619 +PDGFRbeta UP P09619 PGFRB_HUMAN PDGFRbetabeta FPLX 000346 PDGFR_BB -PDGFRβ UP PGFRB_HUMAN P09619 -PDGFRα UP PGFRA_HUMAN P16234 +PDGFRβ UP P09619 PGFRB_HUMAN +PDGFRα UP P16234 PGFRA_HUMAN PDGFRαα FPLX 000344 PDGFR_AA PDGFRαβ FPLX 000345 PDGFR_AB PDGFRββ FPLX 000346 PDGFR_BB PDH FPLX 000352 PDH PDK FPLX 000353 PDK -PDK UP PDPK1_HUMAN O15530 -PDK1 UP PDPK1_HUMAN O15530 +PDK UP O15530 PDPK1_HUMAN +PDK1 UP O15530 PDPK1_HUMAN PDKs FPLX 000353 PDK -PDPK1 UP PDPK1_HUMAN O15530 -PDT MESH Photochemotherapy D010778 -PEA-15 UP PEA15_HUMAN Q15121 -PERK UP E2AK3_HUMAN Q9NZJ5 +PDPK1 UP O15530 PDPK1_HUMAN +PDT MESH D010778 Photochemotherapy +PEA-15 UP Q15121 PEA15_HUMAN +PERK UP Q9NZJ5 E2AK3_HUMAN Peroxiredoxin FPLX 000388 PRDX peroxiredoxin FPLX 000388 PRDX Peroxiredoxins FPLX 000388 PRDX @@ -1981,19 +1981,19 @@ peroxiredoxins FPLX 000388 PRDX Pertussis toxin FPLX 000354 Pertussis_toxin pertussis toxin FPLX 000354 Pertussis_toxin PF-3758309 PUBCHEM 25227462 . -PF-3758309 CHEBI N-[(1S)-2-(dimethylamino)-1-phenylethyl]-6,6-dimethyl-3-[(2-methyl-4-thieno[3,2-d]pyrimidinyl)amino]-1,4-dihydropyrrolo[3,4-c]pyrazole-5-carboxamide CHEBI:93751 -PGC-1alpha UP PRGC1_HUMAN Q9UBK2 -PGC-1α UP PRGC1_HUMAN Q9UBK2 -PGE 2 CHEBI prostaglandin E2-UM CHEBI:73965 +PF-3758309 CHEBI CHEBI:93751 N-[(1S)-2-(dimethylamino)-1-phenylethyl]-6,6-dimethyl-3-[(2-methyl-4-thieno[3,2-d]pyrimidinyl)amino]-1,4-dihydropyrrolo[3,4-c]pyrazole-5-carboxamide +PGC-1alpha UP Q9UBK2 PRGC1_HUMAN +PGC-1α UP Q9UBK2 PRGC1_HUMAN +PGE 2 CHEBI CHEBI:73965 prostaglandin E2-UM PGE 2 PUBCHEM 161468 . -PGE2 UP PE2R4_HUMAN P35408 +PGE2 UP P35408 PE2R4_HUMAN phenformin PUBCHEM 8249 . -phenformin CHEBI phenformin CHEBI:8064 +phenformin CHEBI CHEBI:8064 phenformin PhK FPLX 000356 PhK phosphatase FPLX 000357 Phosphatase phosphatidylinositol 3-kinase FPLX 000358 PI3K -phosphatidylinositol CHEBI phosphatidylinositol CHEBI:28874 -phosphatidylinositol MESH Phosphatidylinositols D010716 +phosphatidylinositol CHEBI CHEBI:28874 phosphatidylinositol +phosphatidylinositol MESH D010716 Phosphatidylinositols phospho-ERK1/2 FPLX 000161 ERK Phosphodiesterase 1 FPLX 000336 PDE1 phosphodiesterase 1 FPLX 000336 PDE1 @@ -2061,21 +2061,21 @@ Phosphorylase kinase FPLX 000356 PhK phosphorylase kinase FPLX 000356 PhK PI 3-kinase FPLX 000358 PI3K PI 3-kinases FPLX 000358 PI3K -PI CHEBI phosphatidylinositol CHEBI:28874 -PI MESH Phosphatidylinositols D010716 +PI CHEBI CHEBI:28874 phosphatidylinositol +PI MESH D010716 Phosphatidylinositols PI3-kinase FPLX 000358 PI3K -PI3K inhibitor CHEBI EC 2.7.1.127 (inositol-trisphosphate 3-kinase) inhibitor CHEBI:84801 +PI3K inhibitor CHEBI CHEBI:84801 EC 2.7.1.127 (inositol-trisphosphate 3-kinase) inhibitor PI3K p110 subunit FPLX 000359 PI3K_p110 PI3K FPLX 000358 PI3K PI3Kinase FPLX 000358 PI3K PIK3C FPLX 000359 PI3K_p110 -PIK3CA UP PK3CA_HUMAN P42336 +PIK3CA UP P42336 PK3CA_HUMAN PIK3R FPLX 000361 PIK3R_I PIM FPLX 000362 PIM -Pin1 UP PIN1_HUMAN Q13526 -PIP CHEBI phosphatidylinositol phosphate CHEBI:28765 -PIP3 MESH phosphatidylinositol 3,4,5-triphosphate C060974 -PIP3 CHEBI phosphatidylinositol trisphosphate CHEBI:60169 +Pin1 UP Q13526 PIN1_HUMAN +PIP CHEBI CHEBI:28765 phosphatidylinositol phosphate +PIP3 MESH C060974 phosphatidylinositol 3,4,5-triphosphate +PIP3 CHEBI CHEBI:60169 phosphatidylinositol trisphosphate PK-A FPLX 000363 PKA PKA catalytic subunit FPLX 000389 PRKAC PKA catalytic subunits FPLX 000389 PRKAC @@ -2086,34 +2086,34 @@ PKB FPLX 000023 AKT PKB-Akt FPLX 000023 AKT PKB/Akt FPLX 000023 AKT PKC FPLX 000364 PKC -PKCalpha UP KPCA_HUMAN P17252 -PKCdelta UP KPCD_HUMAN Q05655 -PKCepsilon UP KPCE_HUMAN Q02156 -PKCα UP KPCA_HUMAN P17252 -PKCε UP KPCE_HUMAN Q02156 -PKCδ UP KPCD_HUMAN Q05655 +PKCalpha UP P17252 KPCA_HUMAN +PKCdelta UP Q05655 KPCD_HUMAN +PKCepsilon UP Q02156 KPCE_HUMAN +PKCα UP P17252 KPCA_HUMAN +PKCε UP Q02156 KPCE_HUMAN +PKCδ UP Q05655 KPCD_HUMAN PKG FPLX 000391 PRKG PKI FPLX 000365 PKI -PKM2 UP KPYM_HUMAN P14618 -PKR UP E2AK2_HUMAN P19525 +PKM2 UP P14618 KPYM_HUMAN +PKR UP P19525 E2AK2_HUMAN PLA2G2 FPLX 000367 PLA2G2 PLA2g2 FPLX 000367 PLA2G2 PLA2G4 FPLX 000368 PLA2G4 -PLB UP PPLA_HUMAN P26678 +PLB UP P26678 PPLA_HUMAN PLC FPLX 000369 PLC PLC-gamma FPLX 000372 PLCG -PLC-gamma1 UP PLCG1_HUMAN P19174 +PLC-gamma1 UP P19174 PLCG1_HUMAN PLC-γ FPLX 000372 PLCG -PLC-γ1 UP PLCG1_HUMAN P19174 -PLCgamma1 UP PLCG1_HUMAN P19174 -PLCγ1 UP PLCG1_HUMAN P19174 -PLK1 UP PLK1_HUMAN P53350 -Plk1 UP PLK1_HUMAN P53350 +PLC-γ1 UP P19174 PLCG1_HUMAN +PLCgamma1 UP P19174 PLCG1_HUMAN +PLCγ1 UP P19174 PLCG1_HUMAN +PLK1 UP P53350 PLK1_HUMAN +Plk1 UP P53350 PLK1_HUMAN PLX PUBCHEM 42611257 . -PLX CHEBI vemurafenib CHEBI:63637 +PLX CHEBI CHEBI:63637 vemurafenib PLX4032 PUBCHEM 42611257 . -PLX4032 CHEBI vemurafenib CHEBI:63637 -PML UP PML_HUMAN P29590 +PLX4032 CHEBI CHEBI:63637 vemurafenib +PML UP P29590 PML_HUMAN Pol delta FPLX 000141 DNA_polymerase_delta pol delta FPLX 000141 DNA_polymerase_delta Pol I FPLX 000416 RNApo_I @@ -2141,11 +2141,11 @@ PP1c FPLX 000377 PPP1C PP1R FPLX 000378 PPP1R PP1r FPLX 000378 PPP1R PP2 phosphatases FPLX 000379 PPP2 -PP2 CHEBI PP2 CHEBI:78331 +PP2 CHEBI CHEBI:78331 PP2 PP2 PUBCHEM 4878 . PP2 FPLX 000379 PPP2 PP242 PUBCHEM 135565635 . -PP242 CHEBI torkinib CHEBI:90679 +PP242 CHEBI CHEBI:90679 torkinib PP2A catalytic C subunit FPLX 000380 PPP2C PP2A regulatory subunit A FPLX 000381 PPP2R_A PP2A regulatory subunit B FPLX 000382 PPP2R_B @@ -2155,33 +2155,33 @@ PP2Ac FPLX 000380 PPP2C PP2B catalytic subunit FPLX 000384 PPP3C PP2B FPLX 000383 PPP3 PPAR FPLX 000375 PPAR -PPAR-gamma UP PPARG_HUMAN P37231 -PPAR-γ UP PPARG_HUMAN P37231 -PPARgamma UP PPARG_HUMAN P37231 -PPARγ UP PPARG_HUMAN P37231 +PPAR-gamma UP P37231 PPARG_HUMAN +PPAR-γ UP P37231 PPARG_HUMAN +PPARgamma UP P37231 PPARG_HUMAN +PPARγ UP P37231 PPARG_HUMAN PPP1 FPLX 000376 PPP1 PPP1C FPLX 000377 PPP1C -PR UP PRGR_HUMAN P06401 -PRAS40 UP AKTS1_HUMAN Q96B36 -pRB UP RB_HUMAN P06400 -pRb UP RB_HUMAN P06400 +PR UP P06401 PRGR_HUMAN +PRAS40 UP Q96B36 AKTS1_HUMAN +pRB UP P06400 RB_HUMAN +pRb UP P06400 RB_HUMAN PRC1 FPLX 000386 PRC1_complex -PRC1 UP PRC1_HUMAN O43663 +PRC1 UP O43663 PRC1_HUMAN PRC2 FPLX 000387 PRC2_complex PRKAA FPLX 000044 AMPK_alpha PRKAB FPLX 000045 AMPK_beta PRKAG FPLX 000046 AMPK_gamma -PRL-3 UP TP4A3_HUMAN O75365 +PRL-3 UP O75365 TP4A3_HUMAN Profilin FPLX 000355 PFN profilin FPLX 000355 PFN Profilins FPLX 000355 PFN profilins FPLX 000355 PFN -progesterone CHEBI progesterone CHEBI:17026 +progesterone CHEBI CHEBI:17026 progesterone progesterone PUBCHEM 5994 . -Proliferation GO cell population proliferation GO:0008283 -Proliferation MESH Cell Proliferation D049109 -proliferation GO cell population proliferation GO:0008283 -proliferation MESH Cell Proliferation D049109 +Proliferation GO GO:0008283 cell population proliferation +Proliferation MESH D049109 Cell Proliferation +proliferation GO GO:0008283 cell population proliferation +proliferation MESH D049109 Cell Proliferation Propionyl-CoA carboxylase FPLX 000392 Propionyl_CoA_carboxylase propionyl-CoA carboxylase FPLX 000392 Propionyl_CoA_carboxylase prostaglandin E receptor FPLX 000395 PTGER @@ -2202,27 +2202,27 @@ protein kinase C FPLX 000364 PKC protein kinase G FPLX 000391 PRKG protein phosphatase 2 FPLX 000379 PPP2 protein phosphatase 2B FPLX 000383 PPP3 -proteolysis GO proteolysis GO:0006508 -proteolysis MESH Proteolysis D059748 -PTC UP PTC_DROME P18502 -Ptc UP PTC_DROME P18502 -ptc UP PTC_DROME P18502 -PTEN UP PTEN_HUMAN P60484 -Pten UP PTEN_HUMAN P60484 -PTP1B UP PTN1_HUMAN P18031 +proteolysis GO GO:0006508 proteolysis +proteolysis MESH D059748 Proteolysis +PTC UP P18502 PTC_DROME +Ptc UP P18502 PTC_DROME +ptc UP P18502 PTC_DROME +PTEN UP P60484 PTEN_HUMAN +Pten UP P60484 PTEN_HUMAN +PTP1B UP P18031 PTN1_HUMAN PTX FPLX 000354 Pertussis_toxin PTX3 HGNC 9692 PTX3 -PTX3 UP PTX3_HUMAN P26022 -PUMA UP BBC3B_HUMAN Q96PG8 +PTX3 UP P26022 PTX3_HUMAN +PUMA UP Q96PG8 BBC3B_HUMAN PYG FPLX 000396 PYG -Pyk2 UP FAK2_HUMAN Q14289 +Pyk2 UP Q14289 FAK2_HUMAN pyruvate dehydrogenase (acetyl-transferring) FPLX 000352 PDH Pyruvate dehydrogenase kinase FPLX 000353 PDK pyruvate dehydrogenase kinase FPLX 000353 PDK -quercetin CHEBI quercetin CHEBI:16243 +quercetin CHEBI CHEBI:16243 quercetin quercetin PUBCHEM 5280343 . RA PUBCHEM 5538 . -RA CHEBI retinoic acid CHEBI:26536 +RA CHEBI CHEBI:26536 retinoic acid RA HMDB HMDB06219 . Rab GTPase FPLX 000397 RAB Rab GTPases FPLX 000397 RAB @@ -2233,17 +2233,17 @@ Rab FPLX 000397 RAB rab FPLX 000397 RAB Rabs FPLX 000397 RAB RAC FPLX 000398 RAC -Rac UP RAC1_HUMAN P63000 -RAC1 UP RAC1_HUMAN P63000 -Rac1 UP RAC1_HUMAN P63000 -RAD51 UP RAD51_HUMAN Q06609 -Rad51 UP RAD51_HUMAN Q06609 -Rad52 UP RAD52_HUMAN P43351 -RAF inhibitors CHEBI B-Raf inhibitor CHEBI:75047 +Rac UP P63000 RAC1_HUMAN +RAC1 UP P63000 RAC1_HUMAN +Rac1 UP P63000 RAC1_HUMAN +RAD51 UP Q06609 RAD51_HUMAN +Rad51 UP Q06609 RAD51_HUMAN +Rad52 UP P43351 RAD52_HUMAN +RAF inhibitors CHEBI CHEBI:75047 B-Raf inhibitor RAF FPLX 000399 RAF Raf FPLX 000399 RAF -Raf-1 UP RAF1_HUMAN P04049 -RAGE UP RAGE_HUMAN Q15109 +Raf-1 UP P04049 RAF1_HUMAN +RAGE UP Q15109 RAGE_HUMAN RAL family FPLX 000400 RAL Ral family FPLX 000400 RAL RAL guanine nucleotide dissociation stimulator like FPLX 000413 RGL @@ -2255,19 +2255,19 @@ RAL proteins FPLX 000400 RAL Ral proteins FPLX 000400 RAL RAL FPLX 000400 RAL RAL HGNC 9839 RALA -RalA UP RALA_HUMAN P11233 +RalA UP P11233 RALA_HUMAN RALGDS-like FPLX 000413 RGL -RANKL UP TNF11_HUMAN O14788 +RANKL UP O14788 TNF11_HUMAN Rap guanine nucleotide exchange factor FPLX 000402 RAPGEF Rap guanine nucleotide exchange factors FPLX 000402 RAPGEF Rap1 FPLX 000401 RAP1 Rapamycin PUBCHEM 5284616 . -Rapamycin CHEBI sirolimus CHEBI:9168 +Rapamycin CHEBI CHEBI:9168 sirolimus rapamycin PUBCHEM 5284616 . -rapamycin CHEBI sirolimus CHEBI:9168 +rapamycin CHEBI CHEBI:9168 sirolimus RapGEFs FPLX 000402 RAPGEF -Raptor UP RPTOR_HUMAN Q8N122 -raptor UP RPTOR_HUMAN Q8N122 +Raptor UP Q8N122 RPTOR_HUMAN +raptor UP Q8N122 RPTOR_HUMAN RAR FPLX 000403 RAR RAS association domain family FPLX 000410 RASSF Ras association domain family FPLX 000410 RASSF @@ -2283,30 +2283,30 @@ RasGAPs FPLX 000407 RasGAP RASGRF FPLX 000408 RASGRF RASGRP FPLX 000409 RASGRP RASSF family FPLX 000410 RASSF -RASSF1A UP RASF1_HUMAN Q9NS23 -RB UP RB_HUMAN P06400 -Rb UP RB_HUMAN P06400 -RB1 UP RB_HUMAN P06400 -Rb1 UP RB_HUMAN P06400 +RASSF1A UP Q9NS23 RASF1_HUMAN +RB UP P06400 RB_HUMAN +Rb UP P06400 RB_HUMAN +RB1 UP P06400 RB_HUMAN +Rb1 UP P06400 RB_HUMAN receptor tyrosine kinase-like orphan receptor FPLX 000420 ROR receptor tyrosine kinase-like orphan receptors FPLX 000420 ROR -REDD1 UP DDIT4_HUMAN Q9NX09 +REDD1 UP Q9NX09 DDIT4_HUMAN regulatory A subunit of PP2A FPLX 000381 PPP2R_A regulatory B subunit of PP2A FPLX 000382 PPP2R_B regulatory family X FPLX 000412 RFX regulatory myosin light chain FPLX 000298 MYL_regulatory regulatory subunit of calcineurin FPLX 000385 PPP3R -RelA UP TF65_HUMAN Q04206 +RelA UP Q04206 TF65_HUMAN replication factor C FPLX 000411 RFC Replication protein A FPLX 000421 RPA replication protein A FPLX 000421 RPA RES PUBCHEM 5281611 . Resveratrol PUBCHEM 445154 . -Resveratrol CHEBI resveratrol CHEBI:27881 +Resveratrol CHEBI CHEBI:27881 resveratrol resveratrol PUBCHEM 445154 . -resveratrol CHEBI resveratrol CHEBI:27881 -RET UP RET_HUMAN P07949 -retinoblastoma protein UP RB_HUMAN P06400 +resveratrol CHEBI CHEBI:27881 resveratrol +RET UP P07949 RET_HUMAN +retinoblastoma protein UP P06400 RB_HUMAN retinoic acid receptors FPLX 000403 RAR retinoid X receptors FPLX 000424 RXR retinoid-X receptor FPLX 000424 RXR @@ -2316,49 +2316,49 @@ RFC FPLX 000411 RFC RFX family FPLX 000412 RFX RFX proteins FPLX 000412 RFX RFX FPLX 000412 RFX -Rheb UP RHEB_HUMAN Q15382 +Rheb UP Q15382 RHEB_HUMAN Rho family FPLX 000414 RHO RHO FPLX 000414 RHO -Rho UP RHOA_HUMAN P61586 +Rho UP P61586 RHOA_HUMAN Rho-GDI FPLX 000415 RhoGDI -RhoA UP RHOA_HUMAN P61586 -RhoB UP RHOB_HUMAN P62745 -RhoC UP RHOC_HUMAN P08134 +RhoA UP P61586 RHOA_HUMAN +RhoB UP P62745 RHOB_HUMAN +RhoC UP P08134 RHOC_HUMAN RHOGDI FPLX 000415 RhoGDI RhoGDI FPLX 000415 RhoGDI rhoGDI FPLX 000415 RhoGDI RhoGDIs FPLX 000415 RhoGDI -ribosomal protein S6 UP RS6_HUMAN P62753 +ribosomal protein S6 UP P62753 RS6_HUMAN ribosomal protein S6 IP IPR000529 . -RICTOR UP RICTR_HUMAN Q6R327 -Rictor UP RICTR_HUMAN Q6R327 -RIG-I UP DDX58_HUMAN O95786 -RIP1 UP RIPK1_HUMAN Q13546 -RKIP UP PEBP1_HUMAN P30086 +RICTOR UP Q6R327 RICTR_HUMAN +Rictor UP Q6R327 RICTR_HUMAN +RIG-I UP O95786 DDX58_HUMAN +RIP1 UP Q13546 RIPK1_HUMAN +RKIP UP P30086 PEBP1_HUMAN RNA polymerase 1 FPLX 000416 RNApo_I RNA polymerase I FPLX 000416 RNApo_I RNA polymerase II FPLX 000417 RNApo_II RNAP II FPLX 000417 RNApo_II ROCK FPLX 000419 ROCK -ROCK1 UP ROCK1_HUMAN Q13464 -ROCK2 UP ROCK2_HUMAN O75116 +ROCK1 UP Q13464 ROCK1_HUMAN +ROCK2 UP O75116 ROCK2_HUMAN ROR FPLX 000420 ROR RORs FPLX 000420 ROR -ROS MESH Reactive Oxygen Species D017382 -ROS UP ROS1_HUMAN P08922 -rosiglitazone CHEBI rosiglitazone CHEBI:50122 +ROS MESH D017382 Reactive Oxygen Species +ROS UP P08922 ROS1_HUMAN +rosiglitazone CHEBI CHEBI:50122 rosiglitazone rosiglitazone PUBCHEM 77999 . -rottlerin CHEBI rottlerin CHEBI:8899 +rottlerin CHEBI CHEBI:8899 rottlerin rottlerin PUBCHEM 5281847 . RPA FPLX 000421 RPA rPKA FPLX 000390 PRKAR RPS6KA FPLX 000329 P90RSK RSK FPLX 000422 RSK -RSK2 UP KS6A3_HUMAN P51812 -RTA UP RFOX2_HUMAN O43251 +RSK2 UP P51812 KS6A3_HUMAN +RTA UP O43251 RFOX2_HUMAN RTKs FPLX 000423 RTK -RUNX2 UP RUNX2_HUMAN Q13950 -rutin CHEBI rutin CHEBI:28527 +RUNX2 UP Q13950 RUNX2_HUMAN +rutin CHEBI CHEBI:28527 rutin rutin PUBCHEM 5280805 . RXR FPLX 000424 RXR S100 FPLX 000425 S100 @@ -2366,49 +2366,49 @@ S100A FPLX 000426 S100A S100a FPLX 000426 S100A S1P receptor FPLX 000427 S1PR S1PR FPLX 000427 S1PR -S6 UP RS6_HUMAN P62753 +S6 UP P62753 RS6_HUMAN S6 IP IPR000529 . S6K FPLX 000328 P70S6K -S6K1 UP KS6B1_HUMAN P23443 +S6K1 UP P23443 KS6B1_HUMAN SAA FPLX 000428 SAA -SAC GO meiotic spindle assembly checkpoint GO:0033316 -SAF-1 UP MAZ_HUMAN P56270 +SAC GO GO:0033316 meiotic spindle assembly checkpoint +SAF-1 UP P56270 MAZ_HUMAN SAHA PUBCHEM 5311 . -SAHA CHEBI vorinostat CHEBI:45716 +SAHA CHEBI CHEBI:45716 vorinostat SAHA CHEMBL CHEMBL98 . sarcoplasmic/endoplasmic reticulum calcium ATPase FPLX 000430 SERCA SB203580 PUBCHEM 176155 . -SB203580 CHEBI SB 203580 CHEBI:90705 -SCF UP SCF_HUMAN P21583 -senescence GO cellular senescence GO:0090398 -senescence MESH Cellular Senescence D016922 +SB203580 CHEBI CHEBI:90705 SB 203580 +SCF UP P21583 SCF_HUMAN +senescence GO GO:0090398 cellular senescence +senescence MESH D016922 Cellular Senescence SERCA FPLX 000430 SERCA SERCAs FPLX 000430 SERCA SFK FPLX 000451 SRC -SFN CHEBI sulforaphane CHEBI:47807 +SFN CHEBI CHEBI:47807 sulforaphane SFN PUBCHEM 5350 . Shc family FPLX 000432 SHC SHC FPLX 000432 SHC Shc FPLX 000432 SHC -shikonin CHEBI Shikonin CHEBI:81068 +shikonin CHEBI CHEBI:81068 Shikonin shikonin PUBCHEM 479503 . -SHP-2 UP PTN11_HUMAN Q06124 -SHP2 UP PTN11_HUMAN Q06124 -Shp2 UP PTN11_HUMAN Q06124 +SHP-2 UP Q06124 PTN11_HUMAN +SHP2 UP Q06124 PTN11_HUMAN +Shp2 UP Q06124 PTN11_HUMAN Sialytransferase FPLX 000202 GTF_family_29 Sialytransferases FPLX 000202 GTF_family_29 sialytransferase FPLX 000202 GTF_family_29 sialytransferases FPLX 000202 GTF_family_29 -signal transduction GO signal transduction GO:0007165 -signal transduction MESH Signal Transduction D015398 -simvastatin CHEBI simvastatin CHEBI:9150 +signal transduction GO GO:0007165 signal transduction +signal transduction MESH D015398 Signal Transduction +simvastatin CHEBI CHEBI:9150 simvastatin simvastatin PUBCHEM 54454 . -SIRT1 UP SIR1_HUMAN Q96EB6 -Sirt1 UP SIR1_HUMAN Q96EB6 -Skp2 UP SKP2_HUMAN Q13309 +SIRT1 UP Q96EB6 SIR1_HUMAN +Sirt1 UP Q96EB6 SIR1_HUMAN +Skp2 UP Q13309 SKP2_HUMAN SLC2 FPLX 000434 SLC2A slow myosin FPLX 000299 MYL_slow -SLP-76 UP LCP2_HUMAN Q13094 +SLP-76 UP Q13094 LCP2_HUMAN SLRP FPLX 000435 SLRP SLRPs FPLX 000435 SLRP SLRR FPLX 000435 SLRP @@ -2417,12 +2417,12 @@ SMAD 2/3 FPLX 000443 SMAD2_3 SMAD FPLX 000441 SMAD Smad FPLX 000441 SMAD smad FPLX 000441 SMAD -Smad2 UP SMAD2_HUMAN Q15796 -smad2 UP SMAD2_HUMAN Q15796 +Smad2 UP Q15796 SMAD2_HUMAN +smad2 UP Q15796 SMAD2_HUMAN SMAD2/3 FPLX 000443 SMAD2_3 Smad2/3 FPLX 000443 SMAD2_3 -Smad3 UP SMAD3_HUMAN P84022 -Smad4 UP SMAD4_HUMAN Q13485 +Smad3 UP P84022 SMAD3_HUMAN +Smad4 UP Q13485 SMAD4_HUMAN small HSPs FPLX 000245 HSPB small leucine rich proteoglycan family FPLX 000435 SLRP small leucine rich proteoglycan FPLX 000435 SLRP @@ -2434,21 +2434,21 @@ SMC1 FPLX 000444 SMC1 Smc1 FPLX 000444 SMC1 SNAI family FPLX 000446 SNAI SNAI FPLX 000446 SNAI -Snail UP SNAI1_HUMAN O95863 +Snail UP O95863 SNAI1_HUMAN SOD FPLX 000447 SOD Sorafenib PUBCHEM 216239 . -Sorafenib CHEBI sorafenib CHEBI:50924 +Sorafenib CHEBI CHEBI:50924 sorafenib sorafenib PUBCHEM 216239 . -sorafenib CHEBI sorafenib CHEBI:50924 +sorafenib CHEBI CHEBI:50924 sorafenib SOS FPLX 000448 SOS -Sos-1 UP SOS1_HUMAN Q07889 -SOS1 UP SOS1_HUMAN Q07889 -Sos1 UP SOS1_HUMAN Q07889 -SOX2 UP SOX2_HUMAN P48431 -Sp1 UP SP1_HUMAN P08047 +Sos-1 UP Q07889 SOS1_HUMAN +SOS1 UP Q07889 SOS1_HUMAN +Sos1 UP Q07889 SOS1_HUMAN +SOX2 UP P48431 SOX2_HUMAN +Sp1 UP P08047 SP1_HUMAN SP600125 PUBCHEM 8515 . -SP600125 CHEBI anthra[1,9-cd]pyrazol-6(2H)-one CHEBI:90695 -SPC CHEBI sphingosine-1-phosphocholine CHEBI:17689 +SP600125 CHEBI CHEBI:90695 anthra[1,9-cd]pyrazol-6(2H)-one +SPC CHEBI CHEBI:17689 sphingosine-1-phosphocholine SPC PUBCHEM 9847290 . Sphingosine 1-phosphate receptor FPLX 000427 S1PR sphingosine-1-phosphate receptors FPLX 000427 S1PR @@ -2458,75 +2458,75 @@ SR Ca(2+)-ATPase FPLX 000430 SERCA Src family kinase FPLX 000451 SRC Src family FPLX 000451 SRC src kinases FPLX 000451 SRC -SRC UP SRC_HUMAN P12931 -Src UP SRC_HUMAN P12931 +SRC UP P12931 SRC_HUMAN +Src UP P12931 SRC_HUMAN SRC-family kinases FPLX 000451 SRC Src-kinases FPLX 000451 SRC SREBF family FPLX 000452 SREBF SREBF FPLX 000452 SREBF -SRF UP SRF_HUMAN P11831 +SRF UP P11831 SRF_HUMAN StAR HGNC 11359 STAR -StAR UP STAR_HUMAN P49675 +StAR UP P49675 STAR_HUMAN STAT FPLX 000453 STAT -STAT1 UP STAT1_HUMAN P42224 -STAT3 UP STAT3_HUMAN P40763 -Stat3 UP STAT3_HUMAN P40763 +STAT1 UP P42224 STAT1_HUMAN +STAT3 UP P40763 STAT3_HUMAN +Stat3 UP P40763 STAT3_HUMAN STAT5 FPLX 000454 STAT5 Stat5 FPLX 000454 STAT5 STATs FPLX 000453 STAT Staurosporine PUBCHEM 44259 . -Staurosporine CHEBI staurosporine CHEBI:15738 +Staurosporine CHEBI CHEBI:15738 staurosporine staurosporine PUBCHEM 44259 . -staurosporine CHEBI staurosporine CHEBI:15738 +staurosporine CHEBI CHEBI:15738 staurosporine stearoyl-CoA 9-desaturase FPLX 000429 SCD Stearoyl-CoA desaturase FPLX 000429 SCD stearoyl-CoA desaturase FPLX 000429 SCD sterol regulatory element binding protein FPLX 000452 SREBF sterol regulatory element-binding factor FPLX 000452 SREBF -STING UP STING_HUMAN Q86WV6 +STING UP Q86WV6 STING_HUMAN STT3 FPLX 000455 STT3 STZ PUBCHEM 29327 . -STZ UP SIA4C_HUMAN Q11206 +STZ UP Q11206 SIA4C_HUMAN succinate dehydrogenase (ubiquinone) FPLX 000502 ETC_complex_II succinate dehydrogenase FPLX 000502 ETC_complex_II Sulfonylurea Receptor FPLX 000456 Sulfonylurea_receptor sulfonylurea receptor FPLX 000456 Sulfonylurea_receptor sulfonylurea receptors FPLX 000456 Sulfonylurea_receptor sulforaphane PUBCHEM 5350 . -sulforaphane CHEBI sulforaphane CHEBI:47807 -superoxide CHEBI superoxide CHEBI:18421 +sulforaphane CHEBI CHEBI:47807 sulforaphane +superoxide CHEBI CHEBI:18421 superoxide superoxide PUBCHEM 5359597 . SUR FPLX 000456 Sulfonylurea_receptor -Survivin UP BIRC5_HUMAN O15392 -survivin UP BIRC5_HUMAN O15392 +Survivin UP O15392 BIRC5_HUMAN +survivin UP O15392 BIRC5_HUMAN SWI and SNF complex FPLX 000457 SWI_SNF SWI/SNF complex FPLX 000457 SWI_SNF SWI/SNF FPLX 000457 SWI_SNF SWI/SNF-like FPLX 000457 SWI_SNF -Syk UP KSYK_HUMAN P43405 -SYNJ2 UP SYNJ2_HUMAN O15056 +Syk UP P43405 KSYK_HUMAN +SYNJ2 UP O15056 SYNJ2_HUMAN T-cell factor (TCF)/lymphoid enhancer factor FPLX 000460 TCF_LEF -TAK1 UP M3K7_HUMAN O43318 +TAK1 UP O43318 M3K7_HUMAN TAK165 PUBCHEM 6444692 . tamoxifen PUBCHEM 2733526 . -tamoxifen CHEBI tamoxifen CHEBI:41774 +tamoxifen CHEBI CHEBI:41774 tamoxifen TAP transporter FPLX 000459 TAP TAP FPLX 000459 TAP -TAp73 UP P73_HUMAN O15350 +TAp73 UP O15350 P73_HUMAN TAS-116 PUBCHEM 67501411 . -Tat UP TAT_HV1H2 P04608 -tau UP TAU_HUMAN P10636 -Tax UP TAX_HTL1A P03409 -TBK1 UP TBK1_HUMAN Q9UHD2 +Tat UP P04608 TAT_HV1H2 +tau UP P10636 TAU_HUMAN +Tax UP P03409 TAX_HTL1A +TBK1 UP Q9UHD2 TBK1_HUMAN TCF FPLX 000460 TCF_LEF Tcf FPLX 000460 TCF_LEF Tcf/Lef FPLX 000460 TCF_LEF TCR FPLX 000461 TCR -TDRG1 UP TDRG1_HUMAN Q3Y452 -telomerase UP TERT_HUMAN O14746 -Temozolomide CHEBI temozolomide CHEBI:72564 +TDRG1 UP Q3Y452 TDRG1_HUMAN +telomerase UP O14746 TERT_HUMAN +Temozolomide CHEBI CHEBI:72564 temozolomide Temozolomide PUBCHEM 5394 . -temozolomide CHEBI temozolomide CHEBI:72564 +temozolomide CHEBI CHEBI:72564 temozolomide temozolomide PUBCHEM 5394 . Tenascin FPLX 000473 TN tenascin FPLX 000473 TN @@ -2537,41 +2537,41 @@ TGF beta receptor FPLX 000466 TGFBR TGF beta FPLX 000465 TGFB TGF β receptor FPLX 000466 TGFBR TGF β FPLX 000465 TGFB -TGF-alpha UP TGFA_HUMAN P01135 +TGF-alpha UP P01135 TGFA_HUMAN TGF-b FPLX 000465 TGFB TGF-beta family FPLX 000465 TGFB TGF-beta receptor FPLX 000466 TGFBR TGF-beta receptors FPLX 000466 TGFBR TGF-beta FPLX 000465 TGFB -TGF-beta1 UP TGFB1_HUMAN P01137 +TGF-beta1 UP P01137 TGFB1_HUMAN TGF-β receptor FPLX 000466 TGFBR TGF-β receptors FPLX 000466 TGFBR TGF-β FPLX 000465 TGFB -TGF-α UP TGFA_HUMAN P01135 -TGF-β1 UP TGFB1_HUMAN P01137 -TGFalpha UP TGFA_HUMAN P01135 +TGF-α UP P01135 TGFA_HUMAN +TGF-β1 UP P01137 TGFB1_HUMAN +TGFalpha UP P01135 TGFA_HUMAN TGFB family FPLX 000465 TGFB TGFB FPLX 000465 TGFB TGFbeta FPLX 000465 TGFB -TGFbeta1 UP TGFB1_HUMAN P01137 +TGFbeta1 UP P01137 TGFB1_HUMAN TGFBR family FPLX 000466 TGFBR TGFBR FPLX 000466 TGFBR TGFβ receptor FPLX 000466 TGFBR TGFβ receptors FPLX 000466 TGFBR TGFβ FPLX 000465 TGFB -TGFα UP TGFA_HUMAN P01135 -TGFβ1 UP TGFB1_HUMAN P01137 +TGFα UP P01135 TGFA_HUMAN +TGFβ1 UP P01137 TGFB1_HUMAN thapsigargin PUBCHEM 446378 . -thapsigargin CHEBI thapsigargin CHEBI:9516 +thapsigargin CHEBI CHEBI:9516 thapsigargin Thioredoxin reductase FPLX 000488 TXNRD thioredoxin reductase FPLX 000488 TXNRD Thioredoxin FPLX 000487 TXN thioredoxin FPLX 000487 TXN -Thioredoxin UP THIO_HUMAN P10599 -thioredoxin UP THIO_HUMAN P10599 +Thioredoxin UP P10599 THIO_HUMAN +thioredoxin UP P10599 THIO_HUMAN thioredoxins FPLX 000487 TXN thrombin IP IPR003966 . -thrombin UP THRB_HUMAN P00734 +thrombin UP P00734 THRB_HUMAN thrombin-anti-thrombin III complexes FPLX 000469 Thrombin_antithrombin thrombospondin protein FPLX 000467 THBS Thrombospondin FPLX 000467 THBS @@ -2580,52 +2580,52 @@ Thrombospondins FPLX 000467 THBS thrombospondins FPLX 000467 THBS thyroid hormone receptor FPLX 000468 THR TIAM FPLX 000470 TIAM -TIAM1 UP TIAM1_HUMAN Q13009 -Tiam1 UP TIAM1_HUMAN Q13009 -TIAM2 UP TIAM2_HUMAN Q8IVF5 -Tiam2 UP TIAM2_HUMAN Q8IVF5 +TIAM1 UP Q13009 TIAM1_HUMAN +Tiam1 UP Q13009 TIAM1_HUMAN +TIAM2 UP Q8IVF5 TIAM2_HUMAN +Tiam2 UP Q8IVF5 TIAM2_HUMAN TIF-IB FPLX 000471 TIF_IB tipifarnib PUBCHEM 159324 . -tipifarnib CHEBI tipifarnib CHEBI:141969 +tipifarnib CHEBI CHEBI:141969 tipifarnib tissue kallikrein FPLX 000271 KLK tissue kallikreins FPLX 000271 KLK TLR FPLX 000472 TLR -TLR2 UP TLR2_HUMAN O60603 -TLR4 UP TLR4_HUMAN O00206 -TMZ CHEBI temozolomide CHEBI:72564 +TLR2 UP O60603 TLR2_HUMAN +TLR4 UP O00206 TLR4_HUMAN +TMZ CHEBI CHEBI:72564 temozolomide TMZ PUBCHEM 5394 . TN-C FPLX 000478 Troponin_C TnC FPLX 000478 Troponin_C -TNF UP TNFA_HUMAN P01375 -TNF-alpha UP TNFA_HUMAN P01375 +TNF UP P01375 TNFA_HUMAN +TNF-alpha UP P01375 TNFA_HUMAN TNF-R superfamily FPLX 000475 TNFRSF TNF-receptor family FPLX 000475 TNFRSF -TNF-α UP TNFA_HUMAN P01375 -TNFalpha UP TNFA_HUMAN P01375 +TNF-α UP P01375 TNFA_HUMAN +TNFalpha UP P01375 TNFA_HUMAN TNFR family FPLX 000475 TNFRSF TNFR subfamily FPLX 000475 TNFRSF TNFR superfamily members FPLX 000475 TNFRSF TNFR superfamily receptors FPLX 000475 TNFRSF TNFR superfamily FPLX 000475 TNFRSF TNFR FPLX 000475 TNFRSF -TNFR1 UP TNR1A_HUMAN P19438 -TNFα UP TNFA_HUMAN P01375 +TNFR1 UP P19438 TNR1A_HUMAN +TNFα UP P01375 TNFA_HUMAN topoisomerase II FPLX 000476 TOP2 TORC1 FPLX 000293 mTORC1 TORC2 FPLX 000294 mTORC2 -TP53 UP P53_HUMAN P04637 +TP53 UP P04637 P53_HUMAN TPA PUBCHEM 27924 . -TPA CHEBI phorbol 13-acetate 12-myristate CHEBI:37537 +TPA CHEBI CHEBI:37537 phorbol 13-acetate 12-myristate Tpl2 HGNC 6860 MAP3K8 TPNI FPLX 000479 Troponin_I TPNT FPLX 000480 Troponin_T TQ PUBCHEM 10281 . -TQ CHEBI 2-methyl-5-propan-2-ylcyclohexa-2,5-diene-1,4-dione CHEBI:113532 -TRAF2 UP TRAF2_HUMAN Q12933 -TRAF3 UP TRAF3_HUMAN Q13114 -TRAF6 UP TRAF6_HUMAN Q9Y4K3 -TRAIL UP TNF10_HUMAN P50591 -trametinib CHEBI trametinib CHEBI:75998 +TQ CHEBI CHEBI:113532 2-methyl-5-propan-2-ylcyclohexa-2,5-diene-1,4-dione +TRAF2 UP Q12933 TRAF2_HUMAN +TRAF3 UP Q13114 TRAF3_HUMAN +TRAF6 UP Q9Y4K3 TRAF6_HUMAN +TRAIL UP P50591 TNF10_HUMAN +trametinib CHEBI CHEBI:75998 trametinib trametinib PUBCHEM 11707110 . Transcription factor AP-2 FPLX 000463 TFAP2 transcription factor AP-2 FPLX 000463 TFAP2 @@ -2634,44 +2634,44 @@ transcription factor II E FPLX 000196 GTF2E transcription factor II F FPLX 000197 GTF2F transcription factor IIE FPLX 000196 GTF2E transcription factor IIF FPLX 000197 GTF2F -transcription GO transcription, DNA-templated GO:0006351 -transcription MESH Transcription, Genetic D014158 +transcription GO GO:0006351 transcription, DNA-templated +transcription MESH D014158 Transcription, Genetic transcriptional cofactor complex CRSP FPLX 000122 CRSP transforming growth factor beta FPLX 000465 TGFB transforming growth factor β FPLX 000465 TGFB transforming growth factor-beta FPLX 000465 TGFB transforming growth factor-β FPLX 000465 TGFB -translation GO translation GO:0006412 -translation MESH Protein Biosynthesis D014176 -transport GO transport GO:0006810 -trastuzumab MESH Trastuzumab D000068878 +translation GO GO:0006412 translation +translation MESH D014176 Protein Biosynthesis +transport GO GO:0006810 transport +trastuzumab MESH D000068878 Trastuzumab trastuzumab CHEMBL 1201585 . TRiC FPLX 000085 CCT_complex -TRIM UP TRAT1_HUMAN Q6PIZ9 +TRIM UP Q6PIZ9 TRAT1_HUMAN Trk receptor FPLX 000321 NTRK trk receptor FPLX 000321 NTRK Trk receptors FPLX 000321 NTRK trk receptors FPLX 000321 NTRK -TrkA UP NTRK1_HUMAN P04629 -TrkB UP NTRK2_HUMAN Q16620 +TrkA UP P04629 NTRK1_HUMAN +TrkB UP Q16620 NTRK2_HUMAN troponin C FPLX 000478 Troponin_C troponin complex FPLX 000477 Troponin troponin I FPLX 000479 Troponin_I troponin T FPLX 000480 Troponin_T troponin FPLX 000477 Troponin troponins FPLX 000477 Troponin -trypsin CHEBI Trypsin CHEBI:9765 +trypsin CHEBI CHEBI:9765 Trypsin Tryptase FPLX 000481 Tryptase tryptase FPLX 000481 Tryptase tryptases FPLX 000481 Tryptase TSA PUBCHEM 444732 . -TSA CHEBI trichostatin A CHEBI:46024 +TSA CHEBI CHEBI:46024 trichostatin A TSC FPLX 000482 TSC -TSC1 UP TSC1_HUMAN Q92574 -TSC2 UP TSC2_HUMAN P49815 +TSC1 UP Q92574 TSC1_HUMAN +TSC2 UP P49815 TSC2_HUMAN TUBA FPLX 000483 TUBA TUBB FPLX 000484 TUBB -tuberin UP TSC2_HUMAN P49815 +tuberin UP P49815 TSC2_HUMAN tubulin alpha chain FPLX 000483 TUBA tubulin beta chain FPLX 000484 TUBB tubulin beta FPLX 000484 TUBB @@ -2685,9 +2685,9 @@ tubulin γ FPLX 000485 TUBG tubulin δ HGNC 16811 TUBD1 tubulin ε HGNC 20775 TUBE1 tubulin FPLX 000486 Tubulin -tumor necrosis factor UP TNFA_HUMAN P01375 -tumorigenesis MESH Carcinogenesis D063646 -tunicamycin CHEBI tunicamycin CHEBI:29699 +tumor necrosis factor UP P01375 TNFA_HUMAN +tumorigenesis MESH D063646 Carcinogenesis +tunicamycin CHEBI CHEBI:29699 tunicamycin tunicamycin PUBCHEM 56927680 . type 2 phosphatidic acid phosphatase FPLX 000374 PPAP2 type 2 phosphatidic acid phosphatases FPLX 000374 PPAP2 @@ -2699,7 +2699,7 @@ type II phosphatidic acid phosphatases FPLX 000374 PPAP2 type V collagen FPLX 000111 COL5 type-V collagen FPLX 000111 COL5 U0126 PUBCHEM 3006531 . -U0126 CHEBI U0126 CHEBI:90693 +U0126 CHEBI CHEBI:90693 U0126 Ub FPLX 000490 Ubiquitin ub FPLX 000490 Ubiquitin UBE2 FPLX 000489 UBE2 @@ -2708,43 +2708,43 @@ Ubiquitin FPLX 000490 Ubiquitin ubiquitin FPLX 000490 Ubiquitin ubiquitin-conjugating enzymes FPLX 000489 UBE2 UGT FPLX 000492 UGT -uPA UP UROK_HUMAN P00749 -uPAR UP UPAR_HUMAN Q03405 +uPA UP P00749 UROK_HUMAN +uPAR UP Q03405 UPAR_HUMAN vascular endothelial growth factor FPLX 000495 VEGF VAV family FPLX 000494 VAV Vav FPLX 000494 VAV -Vav1 UP VAV_HUMAN P15498 -VCAM-1 UP VCAM1_HUMAN P19320 +Vav1 UP P15498 VAV_HUMAN +VCAM-1 UP P19320 VCAM1_HUMAN VEGF receptor FPLX 000496 VEGFR VEGF receptors FPLX 000496 VEGFR VEGF FPLX 000495 VEGF -VEGF-A UP VEGFA_HUMAN P15692 +VEGF-A UP P15692 VEGFA_HUMAN VEGFR ligand FPLX 000496 VEGFR VEGFR FPLX 000496 VEGFR -VEGFR-2 UP VGFR2_HUMAN P35968 -VEGFR2 UP VGFR2_HUMAN P35968 +VEGFR-2 UP P35968 VGFR2_HUMAN +VEGFR2 UP P35968 VGFR2_HUMAN VEGFRs FPLX 000496 VEGFR Vemurafenib PUBCHEM 42611257 . -Vemurafenib CHEBI vemurafenib CHEBI:63637 +Vemurafenib CHEBI CHEBI:63637 vemurafenib vemurafenib PUBCHEM 42611257 . -vemurafenib CHEBI vemurafenib CHEBI:63637 +vemurafenib CHEBI CHEBI:63637 vemurafenib vitronectin receptor (integrin) FPLX 000261 Integrins -VLDL CHEBI very-low-density lipoprotein CHEBI:39027 +VLDL CHEBI CHEBI:39027 very-low-density lipoprotein vorinostat PUBCHEM 5311 . -vorinostat CHEBI vorinostat CHEBI:45716 +vorinostat CHEBI CHEBI:45716 vorinostat VPA PUBCHEM 3121 . -VPA CHEBI valproic acid CHEBI:39867 -Vpr UP VPR_HV1BR P05928 -Vpu UP VPU_HV1H2 P05919 +VPA CHEBI CHEBI:39867 valproic acid +Vpr UP P05928 VPR_HV1BR +Vpu UP P05919 VPU_HV1H2 WA PUBCHEM 265237 . -WA CHEBI withaferin A CHEBI:69120 -wild type c-Cbl UP CBL_HUMAN P22681 +WA CHEBI CHEBI:69120 withaferin A +wild type c-Cbl UP P22681 CBL_HUMAN WNT FPLX 000497 Wnt Wnt FPLX 000497 Wnt -Wnt5a UP WNT5A_HUMAN P41221 +Wnt5a UP P41221 WNT5A_HUMAN wogonin PUBCHEM 5281703 . -wogonin CHEBI wogonin CHEBI:10043 -XIAP UP XIAP_HUMAN P98170 +wogonin CHEBI CHEBI:10043 wogonin +XIAP UP P98170 XIAP_HUMAN XYLT FPLX 000185 GCNT Xylosyltransferase FPLX 000185 GCNT Xylosyltransferases FPLX 000185 GCNT @@ -2752,11 +2752,11 @@ xylosyltransferase FPLX 000185 GCNT xylosyltransferases FPLX 000185 GCNT Y box binding protein FPLX 000498 YBX Y-box-binding protein FPLX 000498 YBX -YAP UP YAP1_HUMAN P46937 -YAP1 UP YAP1_HUMAN P46937 +YAP UP P46937 YAP1_HUMAN +YAP1 UP P46937 YAP1_HUMAN YBX protein family FPLX 000498 YBX -ZEB1 UP ZEB1_HUMAN P37275 -Zeb1 UP ZEB1_HUMAN P37275 +ZEB1 UP P37275 ZEB1_HUMAN +Zeb1 UP P37275 ZEB1_HUMAN β adrenergic receptor kinase FPLX 000022 ADRBK α catenin FPLX 000126 CTNNA β interferons FPLX 000247 IFNB @@ -2772,8 +2772,8 @@ Zeb1 UP ZEB1_HUMAN P37275 α-adrenoreceptors FPLX 000019 ADRA γ-aminobutyric-acid A receptor FPLX 000179 GABR α-catenin FPLX 000126 CTNNA -β-catenin UP CTNB1_HUMAN P35222 -β-TrCP UP FBW1A_HUMAN Q9Y297 +β-catenin UP P35222 CTNB1_HUMAN +β-TrCP UP Q9Y297 FBW1A_HUMAN γ-tubulin FPLX 000485 TUBG δ-tubulin HGNC 16811 TUBD1 ε-tubulin HGNC 20775 TUBE1 @@ -2789,48 +2789,48 @@ Zeb1 UP ZEB1_HUMAN P37275 α2β2γ3 FPLX 000043 AMPK_A2B2G3 βAR FPLX 000021 ADRB βARK FPLX 000022 ADRBK -receptor GO signaling receptor activity GO:0038023 -eGFR MESH Glomerular Filtration Rate D005919 +receptor GO GO:0038023 signaling receptor activity +eGFR MESH D005919 Glomerular Filtration Rate CDK1/2 FPLX 000093 CDK1_2 cdk1/2 FPLX 000093 CDK1_2 Cdk1/2 FPLX 000093 CDK1_2 -cell migration MESH Cell Movement D002465 +cell migration MESH D002465 Cell Movement cell migration NCIT C26169 . -cell migration GO cell migration GO:0016477 -cell motility MESH Cell Movement D002465 +cell migration GO GO:0016477 cell migration +cell motility MESH D002465 Cell Movement cell motility NCIT C16404 . -cell motility GO cell motility GO:0048870 +cell motility GO GO:0048870 cell motility Chk1/2 FPLX 000098 CHEK -chromosomal instability MESH Chromosomal Instability D043171 +chromosomal instability MESH D043171 Chromosomal Instability chromosomal instability NCIT C48195 . -chromosomal instabiliy MESH Chromosomal Instability D043171 +chromosomal instabiliy MESH D043171 Chromosomal Instability chromosomal instabiliy NCIT C48195 . -CIN MESH Chromosomal Instability D043171 +CIN MESH D043171 Chromosomal Instability CIN NCIT C48195 . CycK HGNC 1596 CCNK CycK1 HGNC 1596 CCNK dinaciclib PUBCHEM 46926350 . dinaciclib CHEMBL CHEMBL2103840 . -dinaciclib CHEBI 2-[(2S)-1-[3-ethyl-7-[(1-oxido-3-pyridin-1-iumyl)methylamino]-5-pyrazolo[1,5-a]pyrimidinyl]-2-piperidinyl]ethanol CHEBI:95060 +dinaciclib CHEBI CHEBI:95060 2-[(2S)-1-[3-ethyl-7-[(1-oxido-3-pyridin-1-iumyl)methylamino]-5-pyrazolo[1,5-a]pyrimidinyl]-2-piperidinyl]ethanol Dinaciclib PUBCHEM 46926350 . Dinaciclib CHEMBL CHEMBL2103840 . -Dinaciclib CHEBI 2-[(2S)-1-[3-ethyl-7-[(1-oxido-3-pyridin-1-iumyl)methylamino]-5-pyrazolo[1,5-a]pyrimidinyl]-2-piperidinyl]ethanol CHEBI:95060 +Dinaciclib CHEBI CHEBI:95060 2-[(2S)-1-[3-ethyl-7-[(1-oxido-3-pyridin-1-iumyl)methylamino]-5-pyrazolo[1,5-a]pyrimidinyl]-2-piperidinyl]ethanol Ebp1 HGNC 8550 PA2G4 EBP1 HGNC 8550 PA2G4 erbB FPLX 000160 ERBB Fer-1 PUBCHEM 4068248 . HK2 HGNC 4923 HK2 -NLE CHEBI azadirachtin CHEBI:38473 -PD-1 UP PDCD1_HUMAN Q15116 +NLE CHEBI CHEBI:38473 azadirachtin +PD-1 UP Q15116 PDCD1_HUMAN PD-1 HGNC 8760 PDCD1 Se PUBCHEM 6326970 . -Se CHEBI selenium atom CHEBI:27568 +Se CHEBI CHEBI:27568 selenium atom THZ531 PUBCHEM 118025540 . -THZ531 CHEBI THZ531 CHEBI:143122 +THZ531 CHEBI CHEBI:143122 THZ531 Hh FPLX 000226 Hedgehog SIK FPLX 000433 SIK salt inducible kinase FPLX 000433 SIK -Sik UP PTK6_MOUSE Q64434 +Sik UP Q64434 PTK6_MOUSE DYRK FPLX 000146 DYRK Augmin FPLX 000061 Augmin HAUS FPLX 000061 Augmin diff --git a/famplex/resources/metadata.json b/famplex/resources/metadata.json index f8cde74ee..0e66bfaf3 100644 --- a/famplex/resources/metadata.json +++ b/famplex/resources/metadata.json @@ -1,5 +1,5 @@ { - "Time Exported": "Sun Jul 21 17:01:05 2019", + "Time Exported": "Sun Jul 21 17:49:55 2019", "Unlabelled Groundings": [ { "db": "CHEMBL", diff --git a/famplex/resources/relations.tsv b/famplex/resources/relations.tsv index 778c2c004..b9a29f52f 100644 --- a/famplex/resources/relations.tsv +++ b/famplex/resources/relations.tsv @@ -256,9 +256,9 @@ HGNC 4717 HIST1H1D isa FPLX 000234 Histone_H1 HGNC 4718 HIST1H1E isa FPLX 000234 Histone_H1 HGNC 4720 HIST1H1T isa FPLX 000234 Histone_H1 HGNC 24893 H1FNT isa FPLX 000234 Histone_H1 -UP H2A1_HUMAN P0C0S8 isa FPLX 000235 Histone_H2A +UP P0C0S8 H2A1_HUMAN isa FPLX 000235 Histone_H2A HGNC 22516 H2AFB1 isa FPLX 000235 Histone_H2A -UP H2AB1_HUMAN P0C5Y9 isa FPLX 000235 Histone_H2A +UP P0C5Y9 H2AB1_HUMAN isa FPLX 000235 Histone_H2A HGNC 14456 H2AFJ isa FPLX 000235 Histone_H2A HGNC 20664 H2AFV isa FPLX 000235 Histone_H2A HGNC 4739 H2AFX isa FPLX 000235 Histone_H2A @@ -273,9 +273,9 @@ HGNC 4727 HIST1H2AJ isa FPLX 000235 Histone_H2A HGNC 20508 HIST2H2AB isa FPLX 000235 Histone_H2A HGNC 4738 HIST2H2AC isa FPLX 000235 Histone_H2A HGNC 20507 HIST3H2A isa FPLX 000235 Histone_H2A -UP H2A1B_HUMAN P04908 isa FPLX 000235 Histone_H2A -UP H2A2A_HUMAN Q6FI13 isa FPLX 000235 Histone_H2A -UP H2B1C_HUMAN P62807 isa FPLX 000236 Histone_H2B +UP P04908 H2A1B_HUMAN isa FPLX 000235 Histone_H2A +UP Q6FI13 H2A2A_HUMAN isa FPLX 000235 Histone_H2A +UP P62807 H2B1C_HUMAN isa FPLX 000236 Histone_H2B HGNC 18730 HIST1H2BA isa FPLX 000236 Histone_H2B HGNC 4751 HIST1H2BB isa FPLX 000236 Histone_H2B HGNC 4747 HIST1H2BD isa FPLX 000236 Histone_H2B @@ -294,12 +294,12 @@ HGNC 20514 HIST3H2BB isa FPLX 000236 Histone_H2B HGNC 4762 H2BFS isa FPLX 000236 Histone_H2B HGNC 27867 H2BFM isa FPLX 000236 Histone_H2B HGNC 27252 H2BFWT isa FPLX 000236 Histone_H2B -UP H31_HUMAN P68431 isa FPLX 000237 Histone_H3 -UP H32_HUMAN Q71DI3 isa FPLX 000237 Histone_H3 +UP P68431 H31_HUMAN isa FPLX 000237 Histone_H3 +UP Q71DI3 H32_HUMAN isa FPLX 000237 Histone_H3 HGNC 4778 HIST3H3 isa FPLX 000237 Histone_H3 -UP H33_HUMAN P84243 isa FPLX 000237 Histone_H3 +UP P84243 H33_HUMAN isa FPLX 000237 Histone_H3 HGNC 33164 H3F3C isa FPLX 000237 Histone_H3 -UP H4_HUMAN P62805 isa FPLX 000238 Histone_H4 +UP 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Sep 17 00:00:00 2001 From: Charles Tapley Hoyt Date: Sun, 21 Jul 2019 17:56:38 +0200 Subject: [PATCH 06/19] Update .gitignore --- .gitignore | 1 + 1 file changed, 1 insertion(+) diff --git a/.gitignore b/.gitignore index cffd6de52..a273eef19 100644 --- a/.gitignore +++ b/.gitignore @@ -98,3 +98,4 @@ scratch scratch/* .pytest_cache +.DS_Store From 9729dda419b1f135fea707c4929992af5bc4f8c2 Mon Sep 17 00:00:00 2001 From: Charles Tapley Hoyt Date: Sun, 21 Jul 2019 18:09:58 +0200 Subject: [PATCH 07/19] Delete __init__.py --- export/__init__.py | 0 1 file changed, 0 insertions(+), 0 deletions(-) delete mode 100644 export/__init__.py diff --git a/export/__init__.py b/export/__init__.py deleted file mode 100644 index e69de29bb..000000000 From 24746f68e7268f1d48a082e6aa52a93790e14fd3 Mon Sep 17 00:00:00 2001 From: Charles Tapley Hoyt Date: Sun, 21 Jul 2019 18:20:47 +0200 Subject: [PATCH 08/19] Update hgnc_ids.py --- export/hgnc_ids.py | 47 -------------------------------------- famplex/export/hgnc_ids.py | 42 ++++++++++++++++++++++++++++++++++ 2 files changed, 42 insertions(+), 47 deletions(-) delete mode 100644 export/hgnc_ids.py create mode 100644 famplex/export/hgnc_ids.py diff --git a/export/hgnc_ids.py b/export/hgnc_ids.py deleted file mode 100644 index b5c46dd34..000000000 --- a/export/hgnc_ids.py +++ /dev/null @@ -1,47 +0,0 @@ -"""Several files in this resource use HGNC gene symbols to identify individual -genes. However, the symbols assigned to HGNC IDs can change over time, and -therefore previously curated symbols can become invalid. This script -generates a mapping of current (i.e. at the time of running the script) -mappings of HGNC IDs to symbols so that the assumptions about the identity -of the genes in the various tables can be traced.""" - -import os -import csv -from indra.databases import hgnc_client - -if __name__ == '__main__': - path_this = os.path.dirname(os.path.abspath(__file__)) - hgnc_symbols = set() - # Gather all HGNC symbols from relations.csv - relations_file = os.path.join(path_this, os.pardir, 'relations.csv') - with open(relations_file, 'r') as f: - csvreader = csv.reader(f, delimiter=str(u','), lineterminator='\r\n', - quoting=csv.QUOTE_MINIMAL, - quotechar=str(u'"')) - for row in csvreader: - ns1, id1, rel, ns2, id2 = row - if ns1 == 'HGNC': - hgnc_symbols.add(id1) - if ns2 == 'HGNC': - hgnc_symbols.add(id2) - - # Gather all HGNC symbols from grounding_map.csv - gm_file = os.path.join(path_this, os.pardir, 'grounding_map.csv') - with open(gm_file, 'r') as f: - csvreader = csv.reader(f, delimiter=str(u','), lineterminator='\r\n', - quoting=csv.QUOTE_MINIMAL, - quotechar=str(u'"')) - for row in csvreader: - namespaces = row[1::2] - ids = row[2::2] - for ns, id in zip(namespaces, ids): - if ns == 'HGNC': - hgnc_symbols.add(id) - - # Create output file - out_file = os.path.join(path_this, 'hgnc_symbol_map.csv') - with open(out_file, 'w') as fh: - for hgnc_symbol in sorted(list(hgnc_symbols)): - hgnc_id = hgnc_client.get_hgnc_id(hgnc_symbol) - fh.write('%s,%s\r\n' % (hgnc_symbol, hgnc_id)) - diff --git a/famplex/export/hgnc_ids.py b/famplex/export/hgnc_ids.py new file mode 100644 index 000000000..680a203dc --- /dev/null +++ b/famplex/export/hgnc_ids.py @@ -0,0 +1,42 @@ +"""Several files in this resource use HGNC gene symbols to identify individual +genes. However, the symbols assigned to HGNC IDs can change over time, and +therefore previously curated symbols can become invalid. This script +generates a mapping of current (i.e. at the time of running the script) +mappings of HGNC IDs to symbols so that the assumptions about the identity +of the genes in the various tables can be traced.""" + +import csv +import os + +from famplex.constants import EXPORT_DIR, GROUNDING_MAP_TSV_PATH, RELATIONS_TSV_PATH +from indra.databases import hgnc_client + +HERE = os.path.dirname(os.path.abspath(__file__)) +HGNC_SYMBOL_MAP_PATH = os.path.join(EXPORT_DIR, 'hgnc_symbol_map.csv') + + +def main(): + hgnc_symbols = set() + # Gather all HGNC symbols from relations.csv + with open(RELATIONS_TSV_PATH) as f: + for ns1, id1, n1, rel, ns2, id2, n2 in csv.reader(f, delimiter='\t'): + if ns1 == 'HGNC': + hgnc_symbols.add(n1) + if ns2 == 'HGNC': + hgnc_symbols.add(n2) + + # Gather all HGNC symbols from grounding_map.csv + with open(GROUNDING_MAP_TSV_PATH) as f: + for text, db, db_id, db_name in csv.reader(f, delimiter='\t'): + if db == 'HGNC': + hgnc_symbols.add(db_name) + + # Create output file + with open(HGNC_SYMBOL_MAP_PATH, 'w') as fh: + for hgnc_symbol in sorted(list(hgnc_symbols)): + hgnc_id = hgnc_client.get_hgnc_id(hgnc_symbol) + fh.write('%s,%s\r\n' % (hgnc_symbol, hgnc_id)) + + +if __name__ == '__main__': + main() From b1375cab0a9ef66d397c3a6ef40143f253e32147 Mon Sep 17 00:00:00 2001 From: Charles Tapley Hoyt Date: Sun, 21 Jul 2019 18:20:49 +0200 Subject: [PATCH 09/19] Update .travis.yml --- .travis.yml | 12 ++++-------- 1 file changed, 4 insertions(+), 8 deletions(-) diff --git a/.travis.yml b/.travis.yml index 04320e5bb..962c41806 100644 --- a/.travis.yml +++ b/.travis.yml @@ -4,10 +4,7 @@ python: before_install: - sudo apt-get install graphviz - pwd - - pip install future requests pygraphviz - - if [[ "$TRAVIS_PYTHON_VERSION" == "2.7" ]]; then - pip install functools32; - fi + - pip install future requests pygraphviz bel_resources - git clone https://github.com/sorgerlab/indra.git script: - pwd @@ -19,10 +16,9 @@ script: # bel_resources must be installed to generate belns exports # generate exports then take git diff and look only at lines that changed # lines containing date, timestamp, or version should be ignored - - pip install bel_resources - - python export/obo.py - - python export/hgnc_ids.py - - python export/belns.py + - python famplex/export/obo.py + - python famplex/export/hgnc_ids.py + - python famplex/export/belns.py - export belns_diff=$(git diff -U0 export/famplex.belns | egrep "^[\+-][^\+-]") - export belns=$(echo "$belns_diff" | egrep -v "^[\+-](VersionString|CreatedDateTime)") - export obo_diff=$(git diff -U0 export/famplex.obo | egrep "^[\+-][^\+-]") From 93ea5a24fa835c3f7423d69bd0d2171b132cf463 Mon Sep 17 00:00:00 2001 From: Charles Tapley Hoyt Date: Sun, 21 Jul 2019 18:25:51 +0200 Subject: [PATCH 10/19] Update .travis.yml --- .travis.yml | 8 ++++---- 1 file changed, 4 insertions(+), 4 deletions(-) diff --git a/.travis.yml b/.travis.yml index 962c41806..dc7b60aba 100644 --- a/.travis.yml +++ b/.travis.yml @@ -10,15 +10,15 @@ script: - pwd - echo $TRAVIS_BUILD_DIR - export PYTHONPATH=$PYTHONPATH:$TRAVIS_BUILD_DIR/indra - - python check_references.py - - python export/relations_graph.py + - python famplex/check_references.py + - python famplex/export/export_relations_graph.py # test if exports have been updated # bel_resources must be installed to generate belns exports # generate exports then take git diff and look only at lines that changed # lines containing date, timestamp, or version should be ignored - - python famplex/export/obo.py + - python famplex/export/export_obo.py - python famplex/export/hgnc_ids.py - - python famplex/export/belns.py + - python famplex/export/export_belns.py - export belns_diff=$(git diff -U0 export/famplex.belns | egrep "^[\+-][^\+-]") - export belns=$(echo "$belns_diff" | egrep -v "^[\+-](VersionString|CreatedDateTime)") - export obo_diff=$(git diff -U0 export/famplex.obo | egrep "^[\+-][^\+-]") From 60a74c684cf3abffa1437960037aad7424432ece Mon Sep 17 00:00:00 2001 From: Charles Tapley Hoyt Date: Sun, 21 Jul 2019 18:35:26 +0200 Subject: [PATCH 11/19] Remove duplicates from original grounding map --- famplex/reorganize_old_resources.py | 2 +- famplex/resources/grounding_map.tsv | 10 +++------- grounding_map.csv | 6 ++---- 3 files changed, 6 insertions(+), 12 deletions(-) diff --git a/famplex/reorganize_old_resources.py b/famplex/reorganize_old_resources.py index 26f9569b2..ee2ca531d 100644 --- a/famplex/reorganize_old_resources.py +++ b/famplex/reorganize_old_resources.py @@ -10,7 +10,7 @@ from operator import itemgetter from typing import Tuple -from constants import ( +from famplex.constants import ( ENTITIES_TSV_PATH, EQUIVALENCES_TSV_PATH, GROUNDING_MAP_TSV_PATH, METADATA_PATH, RELATIONS_TSV_PATH, ) diff --git a/famplex/resources/grounding_map.tsv b/famplex/resources/grounding_map.tsv index 13c030b4e..8c370144e 100644 --- a/famplex/resources/grounding_map.tsv +++ b/famplex/resources/grounding_map.tsv @@ -586,8 +586,11 @@ cell growth GO GO:0016049 cell growth cell growth MESH D048708 Cell Growth Processes cell migration GO GO:0016477 cell migration cell migration MESH D002465 Cell Movement +cell migration NCIT C26169 . cell motility GO GO:0016477 cell migration cell motility MESH D002465 Cell Movement +cell motility NCIT C16404 . +cell motility GO GO:0048870 cell motility cell proliferation GO GO:0008283 cell population proliferation cell proliferation MESH D049109 Cell Proliferation cell survival MESH D002470 Cell Survival @@ -1911,7 +1914,6 @@ PBXs FPLX 000334 PBX Pca MESH D011471 Prostatic Neoplasms PCNA UP P12004 PCNA_HUMAN PD MESH D010300 Parkinson Disease -PD-1 HGNC 8760 PDCD1 PD98509 CHEBI CHEBI:79091 EC 2.7.11.24 (mitogen-activated protein kinase) inhibitor PDE 2 HGNC 8777 PDE2A PDE 3 FPLX 000337 PDE3 @@ -2794,12 +2796,6 @@ eGFR MESH D005919 Glomerular Filtration Rate CDK1/2 FPLX 000093 CDK1_2 cdk1/2 FPLX 000093 CDK1_2 Cdk1/2 FPLX 000093 CDK1_2 -cell migration MESH D002465 Cell Movement -cell migration NCIT C26169 . -cell migration GO GO:0016477 cell migration -cell motility MESH D002465 Cell Movement -cell motility NCIT C16404 . -cell motility GO GO:0048870 cell motility Chk1/2 FPLX 000098 CHEK chromosomal instability MESH D043171 Chromosomal Instability chromosomal instability NCIT C48195 . diff --git a/grounding_map.csv b/grounding_map.csv index 5e87c69f4..ecc3bed05 100644 --- a/grounding_map.csv +++ b/grounding_map.csv @@ -529,8 +529,9 @@ cell adhesion,GO,GO:0007155,MESH,D002448,, cell cycle,GO,GO:0007049,MESH,D002453,, cell death,GO,GO:0008219,MESH,D016923,, cell growth,GO,GO:0016049,MESH,D048708,, -cell migration,GO,GO:0016477,MESH,D002465,, +cell migration,GO,GO:0016477,MESH,D002465,NCIT,C26169 cell motility,GO,GO:0016477,MESH,D002465,, +cell motility,NCIT,C16404,GO,GO:0048870,, cell proliferation,GO,GO:0008283,MESH,D049109,, cell survival,MESH,D002470,,,, cell viability,MESH,D002470,,,, @@ -1732,7 +1733,6 @@ PBXs,FPLX,PBX,,,, Pca,MESH,D011471,,,, PCNA,UP,P12004,,,, PD,MESH,D010300,,,, -PD-1,HGNC,PDCD1,,,, PD98509,CHEBI,CHEBI:79091,,,, PDE 2,HGNC,PDE2A,,,, PDE 3,FPLX,PDE3,,,, @@ -2549,8 +2549,6 @@ eGFR,MESH,D005919,,,, CDK1/2,FPLX,CDK1_2,,,, cdk1/2,FPLX,CDK1_2,,,, Cdk1/2,FPLX,CDK1_2,,,, -cell migration,MESH,D002465,NCIT,C26169,GO,GO:0016477 -cell motility,MESH,D002465,NCIT,C16404,GO,GO:0048870 Chk1/2,FPLX,CHEK,,,, chromosomal instability,MESH,D043171,NCIT,C48195,, chromosomal instabiliy,MESH,D043171,NCIT,C48195,, From 6fc3b7aa71e0cc8b5e3ff37982ffca6109af208c Mon Sep 17 00:00:00 2001 From: Charles Tapley Hoyt Date: Sun, 21 Jul 2019 18:53:43 +0200 Subject: [PATCH 12/19] Switch over to CSVs for everything --- descriptions.csv | 1 + descriptions.tsv | 1 - export/famplex.belns | 2 +- export/famplex.obo | 20 +- export/relations_graph.pdf | Bin 647387 -> 647307 bytes famplex/check_references.py | 23 +- famplex/constants.py | 8 +- famplex/export/export_belns.py | 14 +- famplex/export/export_obo.py | 16 +- famplex/export/export_relations_graph.py | 11 +- famplex/reorganize_old_resources.py | 92 +- famplex/resources/entities.csv | 505 ++++ famplex/resources/entities.tsv | 505 ---- famplex/resources/equivalences.csv | 1582 ++++++++++++ famplex/resources/equivalences.tsv | 1582 ------------ famplex/resources/grounding_map.csv | 2834 ++++++++++++++++++++++ famplex/resources/grounding_map.tsv | 2834 ---------------------- famplex/resources/metadata.json | 22 +- famplex/resources/relations.csv | 2784 +++++++++++++++++++++ famplex/resources/relations.tsv | 2784 --------------------- 20 files changed, 7848 insertions(+), 7772 deletions(-) create mode 100644 descriptions.csv delete mode 100644 descriptions.tsv create mode 100644 famplex/resources/entities.csv delete mode 100644 famplex/resources/entities.tsv create mode 100644 famplex/resources/equivalences.csv delete mode 100644 famplex/resources/equivalences.tsv create mode 100644 famplex/resources/grounding_map.csv delete mode 100644 famplex/resources/grounding_map.tsv create mode 100644 famplex/resources/relations.csv delete mode 100644 famplex/resources/relations.tsv diff --git a/descriptions.csv b/descriptions.csv new file mode 100644 index 000000000..2b014b150 --- /dev/null +++ b/descriptions.csv @@ -0,0 +1 @@ +CBF3,interpro:IPR016072,"SKP1 (together with SKP2) was identified as an essential component of the cyclin A-CDK2 S phase kinase complex" diff --git a/descriptions.tsv b/descriptions.tsv deleted file mode 100644 index 87a2b290c..000000000 --- a/descriptions.tsv +++ /dev/null @@ -1 +0,0 @@ -CBF3 interpro:IPR016072 SKP1 (together with SKP2) was identified as an essential component of the cyclin A-CDK2 S phase kinase complex diff --git a/export/famplex.belns b/export/famplex.belns index 7acb328e5..23b26d4eb 100644 --- a/export/famplex.belns +++ b/export/famplex.belns @@ -3,7 +3,7 @@ Keyword=FPLX NameString=FamPlex DomainString=Gene and Gene Products VersionString=20190721 -CreatedDateTime=2019-07-21T16:59:55 +CreatedDateTime=2019-07-21T18:50:59 DescriptionString=FamPlex is a collection of resources for grounding biological entities from text and describing their hierarchical relationships. QueryValueURL=http://identifiers.org/fplx/ [Author] diff --git a/export/famplex.obo b/export/famplex.obo index cf086d6e2..9aba29ba7 100644 --- a/export/famplex.obo +++ b/export/famplex.obo @@ -1,5 +1,5 @@ format-version: 1.2 -date: 21:07:2019 17:01 +date: 21:07:2019 18:51 [Typedef] id: part_of @@ -3946,9 +3946,9 @@ xref: MEDSCAN:urn:agi-protfc:histone%20H2A xref: NCIT:C16684 xref: NEXTPROT-FAMILY:01762 is_a: FPLX:000233 ! Histone -relationship: inverse_is_a UP:H2A1_HUMAN ! P0C0S8 +relationship: inverse_is_a UP:P0C0S8 ! H2A1_HUMAN relationship: inverse_is_a HGNC:22516 ! H2AFB1 -relationship: inverse_is_a UP:H2AB1_HUMAN ! P0C5Y9 +relationship: inverse_is_a UP:P0C5Y9 ! H2AB1_HUMAN relationship: inverse_is_a HGNC:14456 ! H2AFJ relationship: inverse_is_a HGNC:20664 ! H2AFV relationship: inverse_is_a HGNC:4739 ! H2AFX @@ -3963,8 +3963,8 @@ relationship: inverse_is_a HGNC:4727 ! HIST1H2AJ relationship: inverse_is_a HGNC:20508 ! HIST2H2AB relationship: inverse_is_a HGNC:4738 ! HIST2H2AC relationship: inverse_is_a HGNC:20507 ! HIST3H2A -relationship: inverse_is_a UP:H2A1B_HUMAN ! P04908 -relationship: inverse_is_a UP:H2A2A_HUMAN ! Q6FI13 +relationship: inverse_is_a UP:P04908 ! H2A1B_HUMAN +relationship: inverse_is_a UP:Q6FI13 ! H2A2A_HUMAN [Term] id: FPLX:000236 @@ -3974,7 +3974,7 @@ synonym: "histone H2B" EXACT [] xref: BEL:"Histone H2B Family" xref: MEDSCAN:urn:agi-protfc:histone%20H2B is_a: FPLX:000233 ! Histone -relationship: inverse_is_a UP:H2B1C_HUMAN ! P62807 +relationship: inverse_is_a UP:P62807 ! H2B1C_HUMAN relationship: inverse_is_a HGNC:18730 ! HIST1H2BA relationship: inverse_is_a HGNC:4751 ! HIST1H2BB relationship: inverse_is_a HGNC:4747 ! HIST1H2BD @@ -4006,10 +4006,10 @@ xref: MEDSCAN:urn:agi-protfc:histone%20H3 xref: NCIT:C16685 xref: NEXTPROT-FAMILY:01764 is_a: FPLX:000233 ! Histone -relationship: inverse_is_a UP:H31_HUMAN ! P68431 -relationship: inverse_is_a UP:H32_HUMAN ! Q71DI3 +relationship: inverse_is_a UP:P68431 ! H31_HUMAN +relationship: inverse_is_a UP:Q71DI3 ! H32_HUMAN relationship: inverse_is_a HGNC:4778 ! HIST3H3 -relationship: inverse_is_a UP:H33_HUMAN ! P84243 +relationship: inverse_is_a UP:P84243 ! H33_HUMAN relationship: inverse_is_a HGNC:33164 ! H3F3C [Term] @@ -4022,7 +4022,7 @@ xref: MEDSCAN:urn:agi-protfc:histone%20H4 xref: NCIT:C16686 xref: NEXTPROT-FAMILY:01765 is_a: FPLX:000233 ! Histone -relationship: inverse_is_a UP:H4_HUMAN ! P62805 +relationship: inverse_is_a UP:P62805 ! H4_HUMAN relationship: inverse_is_a HGNC:4792 ! 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Tuple[str, str]: return db_id, lookup(db_id) else: - return db_id, '.' + return db_id, '' - with open('descriptions.tsv') as in_file: + with open('descriptions.csv') as in_file: reader = csv.reader( in_file, - delimiter='\t', + delimiter=',', lineterminator='\r\n', + quoting=csv.QUOTE_MINIMAL, + quotechar='"', ) fplx_name_to_description = { fplx_name: ( description, - [r.strip() for r in references.split(',')], + [r.strip() for r in references.split(';')], ) for fplx_name, references, description in reader } with open('entities.csv') as in_file, open(ENTITIES_TSV_PATH, 'w') as out_file: - # print('fplx_id', 'name', 'description', sep='\t', file=out_file) - - # TODO should an explicity entity for famplex be included? - # print('000000', 'famplex', FAMPLEX_DESCRIPTION, sep='\t', file=out_file) + writer = csv.writer( + out_file, + delimiter=',', + quotechar='"', + quoting=csv.QUOTE_MINIMAL, + lineterminator='\r\n', + ) for i, fplx_name in enumerate(in_file, start=1): fplx_name = fplx_name.strip() fplx_id = fplx_name_to_id[fplx_name] = f'{i:06}' description, references = fplx_name_to_description.get(fplx_name, (None, None)) - print( + writer.writerow(( fplx_id, fplx_name, - description if description is not None else '.', - ','.join(references) if references is not None else '.', - sep='\t', - file=out_file, - ) + description if description is not None else '', + ','.join(references) if references is not None else '', + )) with open('equivalences.csv') as in_file, open(EQUIVALENCES_TSV_PATH, 'w') as out_file: # print('xref_db', 'xref_id', 'fplx_id', 'fplx_name', sep='\t', file=out_file) @@ -100,13 +103,23 @@ def get_id_label(db: str, db_id: str) -> Tuple[str, str]: quoting=csv.QUOTE_MINIMAL, quotechar='"', ) + writer = csv.writer( + out_file, + delimiter=',', + quotechar='"', + quoting=csv.QUOTE_MINIMAL, + lineterminator='\r\n', + ) for xref_db, xref_name, fplx_name in reader: - print(xref_db, xref_name, fplx_name_to_id[fplx_name], fplx_name, sep='\t', file=out_file) + writer.writerow(( + xref_db, + xref_name, + fplx_name_to_id[fplx_name], + fplx_name, + )) - grounding_unlabelled = set() + groundings_unlabelled = set() with open('grounding_map.csv') as in_file, open(GROUNDING_MAP_TSV_PATH, 'w') as out_file: - # print('text', 'db', 'identifier', 'name', sep='\t', file=out_file) - reader = csv.reader( in_file, delimiter=',', @@ -114,23 +127,31 @@ def get_id_label(db: str, db_id: str) -> Tuple[str, str]: quoting=csv.QUOTE_MINIMAL, quotechar='"', ) + writer = csv.writer( + out_file, + delimiter=',', + quotechar='"', + quoting=csv.QUOTE_MINIMAL, + lineterminator='\r\n', + ) for text, *line in reader: for xref_db, identifier in zip(line[::2], line[1::2]): if not xref_db or not identifier: continue identifier, xref_name = get_id_label(xref_db, identifier) - if xref_name == '.': - grounding_unlabelled.add((xref_db, identifier)) + if not xref_name: + groundings_unlabelled.add((xref_db, identifier)) - print(text, xref_db, identifier, xref_name, sep='\t', file=out_file) + writer.writerow((text, xref_db, identifier, xref_name)) # Logging for unlabelled entities - print(f'\n{len(grounding_unlabelled)} groundings are unlabelled:') - grounding_unlabelled_counter = Counter(map(itemgetter(0), grounding_unlabelled)) - s = max(map(len, grounding_unlabelled_counter)) - for xref_db, count in grounding_unlabelled_counter.most_common(): - print(f'{xref_db:>{s}s} unlabelled {count}') + if groundings_unlabelled: + print(f'\n{len(groundings_unlabelled)} groundings are unlabelled:') + grounding_unlabelled_counter = Counter(map(itemgetter(0), groundings_unlabelled)) + s = max(map(len, grounding_unlabelled_counter)) + for xref_db, count in grounding_unlabelled_counter.most_common(): + print(f'{xref_db:>{s}s} unlabelled {count}') relations_unlabelled = set() with open('relations.csv') as in_file, open(RELATIONS_TSV_PATH, 'w') as out_file: @@ -144,17 +165,26 @@ def get_id_label(db: str, db_id: str) -> Tuple[str, str]: quoting=csv.QUOTE_MINIMAL, quotechar='"', ) + writer = csv.writer( + out_file, + delimiter=',', + quotechar='"', + quoting=csv.QUOTE_MINIMAL, + lineterminator='\r\n', + ) for sub_db, sub_id, rel, obj_db, obj_id in reader: sub_id, sub_name = get_id_label(sub_db, sub_id) - if sub_name == '.': + if not sub_name: relations_unlabelled.add((sub_db, sub_id)) obj_id, obj_name = get_id_label(obj_db, obj_id) - if obj_name == '.': + if not obj_name: relations_unlabelled.add((obj_db, obj_id)) - print(sub_db, sub_id, sub_name, rel, - obj_db, obj_id, obj_name, sep='\t', file=out_file) + writer.writerow(( + sub_db, sub_id, sub_name, rel, + obj_db, obj_id, obj_name + )) if relations_unlabelled: # Logging for unlabelled entities print(f'\n{len(relations_unlabelled)} relations are unlabelled:') @@ -167,7 +197,7 @@ def get_id_label(db: str, db_id: str) -> Tuple[str, str]: 'Time Exported': str(time.asctime()), 'Unlabelled Groundings': [ dict(db=db, db_id=db_id) - for db, db_id in sorted(grounding_unlabelled) + for db, db_id in sorted(groundings_unlabelled) ], 'Unlabelled Relations': [ dict(db=db, db_id=db_id) diff --git a/famplex/resources/entities.csv b/famplex/resources/entities.csv new file mode 100644 index 000000000..a25a3f801 --- /dev/null +++ b/famplex/resources/entities.csv @@ -0,0 +1,505 @@ +000001,9_1_1,, +000002,A4GALT_family,, +000003,ABL_family,, +000004,ACAD,, +000005,ACC,, +000006,Acetyl_CoA_synthetase,, +000007,ACOX,, +000008,ACSL,, +000009,Actin,, +000010,Activin,, +000011,Activin_A,, +000012,Activin_AB,, +000013,Activin_B,, +000014,ACTN,, +000015,Adaptor_protein_II,, +000016,Adaptor_protein_III,, +000017,ADCY,, +000018,ADH,, +000019,ADRA,, +000020,ADRA2,, +000021,ADRB,, +000022,ADRBK,, +000023,AKT,, +000024,ALDH,, +000025,ALDO,, +000026,ALG10,, +000027,ALG1_family,, +000028,ALG3_family,, +000029,ALG6_family,, +000030,ALG13_family,, +000031,AMPK,, +000032,AMPK_A1B1G1,, +000033,AMPK_A1B1G2,, +000034,AMPK_A1B1G3,, +000035,AMPK_A1B2G1,, +000036,AMPK_A1B2G2,, +000037,AMPK_A1B2G3,, +000038,AMPK_A2B1G1,, +000039,AMPK_A2B1G2,, +000040,AMPK_A2B1G3,, +000041,AMPK_A2B2G1,, +000042,AMPK_A2B2G2,, +000043,AMPK_A2B2G3,, +000044,AMPK_alpha,, +000045,AMPK_beta,, +000046,AMPK_gamma,, +000047,Annexin_II_heterotetramer,, +000048,AP1,, +000049,AP2A,, +000050,APC_C,, +000051,APOA,, +000052,Apolipoprotein,, +000053,ARF_GTPase_family,, +000054,Arp2_3_protein,, +000055,ARRB,, +000056,ATG4,, +000057,ATP1A,, +000058,ATP1B,, +000059,ATP5G,, +000060,ATP_synthase,, +000061,Augmin,, +000062,AXIN,, +000063,B3GAT,, +000064,BCKDC,, +000065,Beta_3_4_GTF,, +000066,BIRC,, +000067,BMP,, +000068,BMP_receptor,, +000069,BMP_receptor_type_I,, +000070,BMP_receptor_type_II,, +000071,BRCA,, +000072,C1,, +000073,C1q,, +000074,Cadherin,, +000075,CALM,, +000076,CAMK,, +000077,CAMK2_complex,, +000078,CAMK2_family,, +000079,CAPN,, +000080,Carboxylesterase,, +000081,Caspase,, +000082,Caspase_3_7,, +000083,CAV,, +000084,CBF3,SKP1 (together with SKP2) was identified as an essential component of the cyclin A-CDK2 S phase kinase complex,interpro:IPR016072 +000085,CCT_complex,, +000086,CD16,, +000087,CD3,, +000088,CD32,, +000089,CD64,, +000090,CD8,, +000091,CDC25,, +000092,CDK,, +000093,CDK1_2,, +000094,CDKN,, +000095,CDKN1,, +000096,CDKN2,, +000097,CEBP,, +000098,CHEK,, +000099,Chemokine,, +000100,Chemokine_receptor,, +000101,Cholinesterase,, +000102,CHRM,, +000103,CHRN,, +000104,CK2,, +000105,Clathrin,, +000106,CNKSR,, +000107,Cofilin,, +000108,Cohesin,, +000109,COL1,, +000110,COL4,, +000111,COL5,, +000112,COLGALT,, +000113,COX,, +000114,COX4,, +000115,COX6A,, +000116,COX6B,, +000117,COX7A,, +000118,COX7B,, +000119,COX8,, +000120,CREB,, +000121,CRISP,, +000122,CRSP,, +000123,CRTC,, +000124,CSNK1,, +000125,CSNK2,, +000126,CTNNA,, +000127,CUL,, +000128,CXCL_ELR_negative,, +000129,CXCL_ELR_positive,, +000130,Cyclin,, +000131,Cyclin_A,, +000132,Cyclin_D,, +000133,Cyclin_E,, +000134,Cyclophilin,, +000135,Cytoplasmic_dynein,, +000136,DDR,, +000137,Death_receptor,, +000138,Desmoglein,, +000139,DGC,, +000140,DGK,, +000141,DNA_polymerase_delta,, +000142,DNM,, +000143,DRD,, +000144,DUSP,, +000145,DVL,, +000146,DYRK,, +000147,E2F,, +000148,E3_Ub_ligase,, +000149,EDN,, +000150,EGFR_ligand,, +000151,EGR,, +000152,EIF2B,, +000153,EIF4A,, +000154,EIF4EBP,, +000155,EIF4G,, +000156,ELA,, +000157,ENO,, +000158,Ephrin_receptor,, +000159,EPN,, +000160,ERBB,, +000161,ERK,, +000162,ESR,, +000163,ETS,, +000164,EXOC,, +000165,EXT,, +000166,FANC,, +000167,FGF,, +000168,FGFR,, +000169,Fibrinogen,, +000170,FLOT,, +000171,FLRT,, +000172,FNT,, +000173,FOS_family,, +000174,FOXO,, +000175,FSH,, +000176,FUT,, +000177,FZD,, +000178,F_actin,, +000179,GABR,, +000180,GALNT,, +000181,Gamma_secretase,, +000182,GAP,, +000183,GAS6_receptor,, +000184,GATA,, +000185,GCNT,, +000186,GEF,, +000187,GPCR,, +000188,GPIb_IX_V,, +000189,GPIT,, +000190,GPX,, +000191,GRIA,, +000192,GRK,, +000193,GRM,, +000194,GSK3,, +000195,GST,, +000196,GTF2E,, +000197,GTF2F,, +000198,Glycosyltransferase,, +000199,GTF_family_2,, +000200,GTF_family_6,, +000201,GTF_family_8,, +000202,GTF_family_29,, +000203,GTF_family_90,, +000204,GTPase,, +000205,GUCY,, +000206,GYS,, +000207,G_12,, +000208,G_12_alpha,, +000209,G_alpha,, +000210,G_beta,, +000211,G_gamma,, +000212,G_i,, +000213,G_i_alpha,, +000214,G_protein,, +000215,G_q,, +000216,G_q_alpha,, +000217,G_s,, +000218,G_s_alpha,, +000219,hCG,, +000220,HDAC,, +000221,HDAC_I,, +000222,HDAC_II,, +000223,HDAC_III,, +000224,HDAC_IV,, +000225,HDL,, +000226,Hedgehog,, +000227,Hemoglobin,, +000228,HES,, +000229,HIF,, +000230,HIF1,, +000231,HIF_alpha,, +000232,HIF_beta,, +000233,Histone,, +000234,Histone_H1,, +000235,Histone_H2A,, +000236,Histone_H2B,, +000237,Histone_H3,, +000238,Histone_H4,, +000239,HLA_DR,, +000240,HMOX,, +000241,HSP90,, +000242,HSP90A,, +000243,HSP90AA,, +000244,HSPA,, +000245,HSPB,, +000246,IFNA,, +000247,IFNB,, +000248,IGFBP,, +000249,IKB,, +000250,IKK_complex,, +000251,IKK_family,, +000252,IL1,, +000253,IL12,, +000254,IL15R,, +000255,IL2R,, +000256,Inhibin,, +000257,Inhibin_A,, +000258,Inhibin_B,, +000259,INS,, +000260,INSR,, +000261,Integrins,, +000262,Interferon,, +000263,Interferon_gamma_receptor,, +000264,IRS,, +000265,IRX,, +000266,JAK,, +000267,JNK,, +000268,JUN_family,, +000269,Kainate_family,, +000270,Kinetochore,, +000271,KLK,, +000272,KSR,, +000273,Laminin_111,, +000274,Laminin_332,, +000275,LDH,, +000276,LH,, +000277,LPAR,, +000278,MAC,, +000279,MAF,, +000280,MAP1LC3,, +000281,MAP2K,, +000282,MAP3K,, +000283,MAPK,, +000284,MCM,, +000285,MEF2,, +000286,MEK,, +000287,MGAT,, +000288,Mitochondrial_Ribosome,, +000289,MRPS,, +000290,MRPL,, +000291,MMP,, +000292,Metallothionein,, +000293,mTORC1,, +000294,mTORC2,, +000295,MYH,, +000296,MYL,, +000297,MYL_alkali,, +000298,MYL_regulatory,, +000299,MYL_slow,, +000300,MYST,, +000301,NADH_dehydrogenase,, +000302,NADPH_oxidase,, +000303,Na_K_ATPase,, +000304,Natriuretic_peptide,, +000305,NCOA,, +000306,NCOR,, +000307,NDRG,, +000308,Neurexins,, +000309,NFAT,, +000310,NFE,, +000311,NFkappaB,, +000312,NFkappaB_1,, +000313,NFkappaB_2,, +000314,NFY,, +000315,NKD,, +000316,NOS,, +000317,Notch,, +000318,NRG,, +000319,NRG_1_2,, +000320,NRG_3_4,, +000321,NTRK,, +000322,OGT_family,, +000323,p14_3_3,, +000324,P2RX,, +000325,P2RY,, +000326,p38,, +000327,p53_family,, +000328,P70S6K,, +000329,P90RSK,, +000330,PAK,, +000331,PARP,, +000332,PARV,, +000333,Patched,, +000334,PBX,, +000335,PDE,, +000336,PDE1,, +000337,PDE3,, +000338,PDE4,, +000339,PDE6,, +000340,PDE7,, +000341,PDE8,, +000342,PDGF,, +000343,PDGFR,, +000344,PDGFR_AA,, +000345,PDGFR_AB,, +000346,PDGFR_BB,, +000347,PDGF_AA,, +000348,PDGF_AB,, +000349,PDGF_BB,, +000350,PDGF_CC,, +000351,PDGF_DD,, +000352,PDH,, +000353,PDK,, +000354,Pertussis_toxin,, +000355,PFN,, +000356,PhK,, +000357,Phosphatase,, +000358,PI3K,, +000359,PI3K_p110,, +000360,PI3K_p85,, +000361,PIK3R_I,, +000362,PIM,, +000363,PKA,, +000364,PKC,, +000365,PKI,, +000366,PLA2,, +000367,PLA2G2,, +000368,PLA2G4,, +000369,PLC,, +000370,PLCB,, +000371,PLCD,, +000372,PLCG,, +000373,PLD,, +000374,PPAP2,, +000375,PPAR,, +000376,PPP1,, +000377,PPP1C,, +000378,PPP1R,, +000379,PPP2,, +000380,PPP2C,, +000381,PPP2R_A,, +000382,PPP2R_B,, +000383,PPP3,, +000384,PPP3C,, +000385,PPP3R,, +000386,PRC1_complex,, +000387,PRC2_complex,, +000388,PRDX,, +000389,PRKAC,, +000390,PRKAR,, +000391,PRKG,, +000392,Propionyl_CoA_carboxylase,, +000393,Protease,, +000394,Proteasome,, +000395,PTGER,, +000396,PYG,, +000397,RAB,, +000398,RAC,, +000399,RAF,, +000400,RAL,, +000401,RAP1,, +000402,RAPGEF,, +000403,RAR,, +000404,RAS,, +000405,RASA,, +000406,RASAL,, +000407,RasGAP,, +000408,RASGRF,, +000409,RASGRP,, +000410,RASSF,, +000411,RFC,, +000412,RFX,, +000413,RGL,, +000414,RHO,, +000415,RhoGDI,, +000416,RNApo_I,, +000417,RNApo_II,, +000418,ROBO,, +000419,ROCK,, +000420,ROR,, +000421,RPA,, +000422,RSK,, +000423,RTK,, +000424,RXR,, +000425,S100,, +000426,S100A,, +000427,S1PR,, +000428,SAA,, +000429,SCD,, +000430,SERCA,, +000431,SERPINB,, +000432,SHC,, +000433,SIK,, +000434,SLC2A,, +000435,SLRP,, +000436,SLRP_1,, +000437,SLRP_2,, +000438,SLRP_3,, +000439,SLRP_4,, +000440,SLRP_5,, +000441,SMAD,, +000442,SMAD1_5_9,, +000443,SMAD2_3,, +000444,SMC1,, +000445,SMURF,, +000446,SNAI,, +000447,SOD,, +000448,SOS,, +000449,SPRED,, +000450,SPRY,, +000451,SRC,, +000452,SREBF,, +000453,STAT,, +000454,STAT5,, +000455,STT3,, +000456,Sulfonylurea_receptor,, +000457,SWI_SNF,, +000458,TAOK,, +000459,TAP,, +000460,TCF_LEF,, +000461,TCR,, +000462,TEAD,, +000463,TFAP2,, +000464,TFDP,, +000465,TGFB,, +000466,TGFBR,, +000467,THBS,, +000468,THR,, +000469,Thrombin_antithrombin,, +000470,TIAM,, +000471,TIF_IB,, +000472,TLR,, +000473,TN,, +000474,TNF,, +000475,TNFRSF,, +000476,TOP2,, +000477,Troponin,, +000478,Troponin_C,, +000479,Troponin_I,, +000480,Troponin_T,, +000481,Tryptase,, +000482,TSC,, +000483,TUBA,, +000484,TUBB,, +000485,TUBG,, +000486,Tubulin,, +000487,TXN,, +000488,TXNRD,, +000489,UBE2,, +000490,Ubiquitin,, +000491,UGCG,, +000492,UGT,, +000493,UGGT,, +000494,VAV,, +000495,VEGF,, +000496,VEGFR,, +000497,Wnt,, +000498,YBX,, +000499,ETC_complex_I_core,, +000500,ETC_complex_I_supernumerary,, +000501,ETC_complex_I,, +000502,ETC_complex_II,, +000503,ETC_complex_III,, +000504,ETC_complex_IV,, +000505,ETC_complex_V,, diff --git a/famplex/resources/entities.tsv b/famplex/resources/entities.tsv deleted file mode 100644 index 386631137..000000000 --- a/famplex/resources/entities.tsv +++ /dev/null @@ -1,505 +0,0 @@ -000001 9_1_1 . . -000002 A4GALT_family . . -000003 ABL_family . . -000004 ACAD . . -000005 ACC . . -000006 Acetyl_CoA_synthetase . . -000007 ACOX . . -000008 ACSL . . -000009 Actin . . -000010 Activin . . -000011 Activin_A . . -000012 Activin_AB . . -000013 Activin_B . . -000014 ACTN . . -000015 Adaptor_protein_II . . -000016 Adaptor_protein_III . . -000017 ADCY . . -000018 ADH . . -000019 ADRA . . -000020 ADRA2 . . -000021 ADRB . . -000022 ADRBK . . -000023 AKT . . -000024 ALDH . . -000025 ALDO . . -000026 ALG10 . . -000027 ALG1_family . . -000028 ALG3_family . . -000029 ALG6_family . . -000030 ALG13_family . . -000031 AMPK . . -000032 AMPK_A1B1G1 . . -000033 AMPK_A1B1G2 . . -000034 AMPK_A1B1G3 . . -000035 AMPK_A1B2G1 . . -000036 AMPK_A1B2G2 . . -000037 AMPK_A1B2G3 . . -000038 AMPK_A2B1G1 . . -000039 AMPK_A2B1G2 . . -000040 AMPK_A2B1G3 . . -000041 AMPK_A2B2G1 . . -000042 AMPK_A2B2G2 . . -000043 AMPK_A2B2G3 . . -000044 AMPK_alpha . . -000045 AMPK_beta . . -000046 AMPK_gamma . . -000047 Annexin_II_heterotetramer . . -000048 AP1 . . -000049 AP2A . . -000050 APC_C . . -000051 APOA . . -000052 Apolipoprotein . . -000053 ARF_GTPase_family . . -000054 Arp2_3_protein . . -000055 ARRB . . -000056 ATG4 . . -000057 ATP1A . . -000058 ATP1B . . -000059 ATP5G . . -000060 ATP_synthase . . -000061 Augmin . . -000062 AXIN . . -000063 B3GAT . . -000064 BCKDC . . -000065 Beta_3_4_GTF . . -000066 BIRC . . -000067 BMP . . -000068 BMP_receptor . . -000069 BMP_receptor_type_I . . -000070 BMP_receptor_type_II . . -000071 BRCA . . -000072 C1 . . -000073 C1q . . -000074 Cadherin . . -000075 CALM . . -000076 CAMK . . -000077 CAMK2_complex . . -000078 CAMK2_family . . -000079 CAPN . . -000080 Carboxylesterase . . -000081 Caspase . . -000082 Caspase_3_7 . . -000083 CAV . . -000084 CBF3 SKP1 (together with SKP2) was identified as an essential component of the cyclin A-CDK2 S phase kinase complex interpro:IPR016072 -000085 CCT_complex . . -000086 CD16 . . -000087 CD3 . . -000088 CD32 . . -000089 CD64 . . -000090 CD8 . . -000091 CDC25 . . -000092 CDK . . -000093 CDK1_2 . . -000094 CDKN . . -000095 CDKN1 . . -000096 CDKN2 . . -000097 CEBP . . -000098 CHEK . . -000099 Chemokine . . -000100 Chemokine_receptor . . -000101 Cholinesterase . . -000102 CHRM . . -000103 CHRN . . -000104 CK2 . . -000105 Clathrin . . -000106 CNKSR . . -000107 Cofilin . . -000108 Cohesin . . -000109 COL1 . . -000110 COL4 . . -000111 COL5 . . -000112 COLGALT . . -000113 COX . . -000114 COX4 . . -000115 COX6A . . -000116 COX6B . . -000117 COX7A . . -000118 COX7B . . -000119 COX8 . . -000120 CREB . . -000121 CRISP . . -000122 CRSP . . -000123 CRTC . . -000124 CSNK1 . . -000125 CSNK2 . . -000126 CTNNA . . -000127 CUL . . -000128 CXCL_ELR_negative . . -000129 CXCL_ELR_positive . . -000130 Cyclin . . -000131 Cyclin_A . . -000132 Cyclin_D . . -000133 Cyclin_E . . -000134 Cyclophilin . . -000135 Cytoplasmic_dynein . . -000136 DDR . . -000137 Death_receptor . . -000138 Desmoglein . . -000139 DGC . . -000140 DGK . . -000141 DNA_polymerase_delta . . -000142 DNM . . -000143 DRD . . -000144 DUSP . . -000145 DVL . . -000146 DYRK . . -000147 E2F . . -000148 E3_Ub_ligase . . -000149 EDN . . -000150 EGFR_ligand . . -000151 EGR . . -000152 EIF2B . . -000153 EIF4A . . -000154 EIF4EBP . . -000155 EIF4G . . -000156 ELA . . -000157 ENO . . -000158 Ephrin_receptor . . -000159 EPN . . -000160 ERBB . . -000161 ERK . . -000162 ESR . . -000163 ETS . . -000164 EXOC . . -000165 EXT . . -000166 FANC . . -000167 FGF . . -000168 FGFR . . -000169 Fibrinogen . . -000170 FLOT . . -000171 FLRT . . -000172 FNT . . -000173 FOS_family . . -000174 FOXO . . -000175 FSH . . -000176 FUT . . -000177 FZD . . -000178 F_actin . . -000179 GABR . . -000180 GALNT . . -000181 Gamma_secretase . . -000182 GAP . . -000183 GAS6_receptor . . -000184 GATA . . -000185 GCNT . . -000186 GEF . . -000187 GPCR . . -000188 GPIb_IX_V . . -000189 GPIT . . -000190 GPX . . -000191 GRIA . . -000192 GRK . . -000193 GRM . . -000194 GSK3 . . -000195 GST . . -000196 GTF2E . . -000197 GTF2F . . -000198 Glycosyltransferase . . -000199 GTF_family_2 . . -000200 GTF_family_6 . . -000201 GTF_family_8 . . -000202 GTF_family_29 . . -000203 GTF_family_90 . . -000204 GTPase . . -000205 GUCY . . -000206 GYS . . -000207 G_12 . . -000208 G_12_alpha . . -000209 G_alpha . . -000210 G_beta . . -000211 G_gamma . . -000212 G_i . . -000213 G_i_alpha . . -000214 G_protein . . -000215 G_q . . -000216 G_q_alpha . . -000217 G_s . . -000218 G_s_alpha . . -000219 hCG . . -000220 HDAC . . -000221 HDAC_I . . -000222 HDAC_II . . -000223 HDAC_III . . -000224 HDAC_IV . . -000225 HDL . . -000226 Hedgehog . . -000227 Hemoglobin . . -000228 HES . . -000229 HIF . . -000230 HIF1 . . -000231 HIF_alpha . . -000232 HIF_beta . . -000233 Histone . . -000234 Histone_H1 . . -000235 Histone_H2A . . -000236 Histone_H2B . . -000237 Histone_H3 . . -000238 Histone_H4 . . -000239 HLA_DR . . -000240 HMOX . . -000241 HSP90 . . -000242 HSP90A . . -000243 HSP90AA . . -000244 HSPA . . -000245 HSPB . . -000246 IFNA . . -000247 IFNB . . -000248 IGFBP . . -000249 IKB . . -000250 IKK_complex . . -000251 IKK_family . . -000252 IL1 . . -000253 IL12 . . -000254 IL15R . . -000255 IL2R . . -000256 Inhibin . . -000257 Inhibin_A . . -000258 Inhibin_B . . -000259 INS . . -000260 INSR . . -000261 Integrins . . -000262 Interferon . . -000263 Interferon_gamma_receptor . . -000264 IRS . . -000265 IRX . . -000266 JAK . . -000267 JNK . . -000268 JUN_family . . -000269 Kainate_family . . -000270 Kinetochore . . -000271 KLK . . -000272 KSR . . -000273 Laminin_111 . . -000274 Laminin_332 . . -000275 LDH . . -000276 LH . . -000277 LPAR . . -000278 MAC . . -000279 MAF . . -000280 MAP1LC3 . . -000281 MAP2K . . -000282 MAP3K . . -000283 MAPK . . -000284 MCM . . -000285 MEF2 . . -000286 MEK . . -000287 MGAT . . -000288 Mitochondrial_Ribosome . . -000289 MRPS . . -000290 MRPL . . -000291 MMP . . -000292 Metallothionein . . -000293 mTORC1 . . -000294 mTORC2 . . -000295 MYH . . -000296 MYL . . -000297 MYL_alkali . . -000298 MYL_regulatory . . -000299 MYL_slow . . -000300 MYST . . -000301 NADH_dehydrogenase . . -000302 NADPH_oxidase . . -000303 Na_K_ATPase . . -000304 Natriuretic_peptide . . -000305 NCOA . . -000306 NCOR . . -000307 NDRG . . -000308 Neurexins . . -000309 NFAT . . -000310 NFE . . -000311 NFkappaB . . -000312 NFkappaB_1 . . -000313 NFkappaB_2 . . -000314 NFY . . -000315 NKD . . -000316 NOS . . -000317 Notch . . -000318 NRG . . -000319 NRG_1_2 . . -000320 NRG_3_4 . . -000321 NTRK . . -000322 OGT_family . . -000323 p14_3_3 . . -000324 P2RX . . -000325 P2RY . . -000326 p38 . . -000327 p53_family . . -000328 P70S6K . . -000329 P90RSK . . -000330 PAK . . -000331 PARP . . -000332 PARV . . -000333 Patched . . -000334 PBX . . -000335 PDE . . -000336 PDE1 . . -000337 PDE3 . . -000338 PDE4 . . -000339 PDE6 . . -000340 PDE7 . . -000341 PDE8 . . -000342 PDGF . . -000343 PDGFR . . -000344 PDGFR_AA . . -000345 PDGFR_AB . . -000346 PDGFR_BB . . -000347 PDGF_AA . . -000348 PDGF_AB . . -000349 PDGF_BB . . -000350 PDGF_CC . . -000351 PDGF_DD . . -000352 PDH . . -000353 PDK . . -000354 Pertussis_toxin . . -000355 PFN . . -000356 PhK . . -000357 Phosphatase . . -000358 PI3K . . -000359 PI3K_p110 . . -000360 PI3K_p85 . . -000361 PIK3R_I . . -000362 PIM . . -000363 PKA . . -000364 PKC . . -000365 PKI . . -000366 PLA2 . . -000367 PLA2G2 . . -000368 PLA2G4 . . -000369 PLC . . -000370 PLCB . . -000371 PLCD . . -000372 PLCG . . -000373 PLD . . -000374 PPAP2 . . -000375 PPAR . . -000376 PPP1 . . -000377 PPP1C . . -000378 PPP1R . . -000379 PPP2 . . -000380 PPP2C . . -000381 PPP2R_A . . -000382 PPP2R_B . . -000383 PPP3 . . -000384 PPP3C . . -000385 PPP3R . . -000386 PRC1_complex . . -000387 PRC2_complex . . -000388 PRDX . . -000389 PRKAC . . -000390 PRKAR . . -000391 PRKG . . -000392 Propionyl_CoA_carboxylase . . -000393 Protease . . -000394 Proteasome . . -000395 PTGER . . -000396 PYG . . -000397 RAB . . -000398 RAC . . -000399 RAF . . -000400 RAL . . -000401 RAP1 . . -000402 RAPGEF . . -000403 RAR . . -000404 RAS . . -000405 RASA . . -000406 RASAL . . -000407 RasGAP . . -000408 RASGRF . . -000409 RASGRP . . -000410 RASSF . . -000411 RFC . . -000412 RFX . . -000413 RGL . . -000414 RHO . . -000415 RhoGDI . . -000416 RNApo_I . . -000417 RNApo_II . . -000418 ROBO . . -000419 ROCK . . -000420 ROR . . -000421 RPA . . -000422 RSK . . -000423 RTK . . -000424 RXR . . -000425 S100 . . -000426 S100A . . -000427 S1PR . . -000428 SAA . . -000429 SCD . . -000430 SERCA . . -000431 SERPINB . . -000432 SHC . . -000433 SIK . . -000434 SLC2A . . -000435 SLRP . . -000436 SLRP_1 . . -000437 SLRP_2 . . -000438 SLRP_3 . . -000439 SLRP_4 . . -000440 SLRP_5 . . -000441 SMAD . . -000442 SMAD1_5_9 . . -000443 SMAD2_3 . . -000444 SMC1 . . -000445 SMURF . . -000446 SNAI . . -000447 SOD . . -000448 SOS . . -000449 SPRED . . -000450 SPRY . . -000451 SRC . . -000452 SREBF . . -000453 STAT . . -000454 STAT5 . . -000455 STT3 . . -000456 Sulfonylurea_receptor . . -000457 SWI_SNF . . -000458 TAOK . . -000459 TAP . . -000460 TCF_LEF . . -000461 TCR . . -000462 TEAD . . -000463 TFAP2 . . -000464 TFDP . . -000465 TGFB . . -000466 TGFBR . . -000467 THBS . . -000468 THR . . -000469 Thrombin_antithrombin . . -000470 TIAM . . -000471 TIF_IB . . -000472 TLR . . -000473 TN . . -000474 TNF . . -000475 TNFRSF . . -000476 TOP2 . . -000477 Troponin . . -000478 Troponin_C . . -000479 Troponin_I . . -000480 Troponin_T . . -000481 Tryptase . . -000482 TSC . . -000483 TUBA . . -000484 TUBB . . -000485 TUBG . . -000486 Tubulin . . -000487 TXN . . -000488 TXNRD . . -000489 UBE2 . . -000490 Ubiquitin . . -000491 UGCG . . -000492 UGT . . -000493 UGGT . . -000494 VAV . . -000495 VEGF . . -000496 VEGFR . . -000497 Wnt . . -000498 YBX . . -000499 ETC_complex_I_core . . -000500 ETC_complex_I_supernumerary . . -000501 ETC_complex_I . . -000502 ETC_complex_II . . -000503 ETC_complex_III . . -000504 ETC_complex_IV . . -000505 ETC_complex_V . . diff --git a/famplex/resources/equivalences.csv b/famplex/resources/equivalences.csv new file mode 100644 index 000000000..86383dda2 --- /dev/null +++ b/famplex/resources/equivalences.csv @@ -0,0 +1,1582 @@ +BEL,14-3-3 Family,000323,p14_3_3 +BEL,9-1-1 Complex,000001,9_1_1 +BEL,ACAD Family,000004,ACAD +BEL,Acetyl CoA Carboxylase Complex,000005,ACC +BEL,Acetyl-CoA Synthetase Family,000006,Acetyl_CoA_synthetase +BEL,ACOX Family,000007,ACOX +BEL,ACSL Family,000008,ACSL +BEL,ACT Family,000009,Actin +BEL,ACTN Family,000014,ACTN +BEL,Adaptor Protein II Complex,000015,Adaptor_protein_II +BEL,Adaptor Protein III Complex,000016,Adaptor_protein_III +BEL,ADCY Family,000017,ADCY +BEL,ADH Family,000018,ADH +BEL,ADRA Family,000019,ADRA +BEL,ADRA2 Family,000020,ADRA2 +BEL,ADRB Family,000021,ADRB +BEL,ADRBK Family,000022,ADRBK +BEL,AKT Family,000023,AKT +BEL,ALDH Family,000024,ALDH +BEL,ALDO Family,000025,ALDO +BEL,AMP Activated Protein Kinase Complex,000031,AMPK +BEL,Annexin II Heterotetramer Complex,000047,Annexin_II_heterotetramer +BEL,AP-1 Complex,000048,AP1 +BEL,APOA Family,000051,APOA +BEL,Arp2/3 Protein Complex,000054,Arp2_3_protein +BEL,ARRB Family,000055,ARRB +BEL,ATP2A Family,000430,SERCA +BEL,ATP5G Family,000059,ATP5G +BEL,AXIN Family,000062,AXIN +BEL,BIRC Family,000066,BIRC +BEL,BMP Family,000067,BMP +BEL,BMP Receptor Type I Family,000069,BMP_receptor_type_I +BEL,BMP Receptor Type II Family,000070,BMP_receptor_type_II +BEL,Branched Chain Alpha Keto Acid Dehydrogenase Complex,000064,BCKDC +BEL,C1 Complex,000072,C1 +BEL,C1q Complex,000073,C1q +BEL,Calcineurin Complex,000383,PPP3 +BEL,CALM Family,000075,CALM +BEL,CAMK Family,000076,CAMK +BEL,CAMK2 Complex,000077,CAMK2_complex +BEL,CAMK2 Family,000078,CAMK2_family +BEL,CAPN Family,000079,CAPN +BEL,Carboxylesterase Family,000080,Carboxylesterase +BEL,CASP Family,000081,Caspase +BEL,CAV Family,000083,CAV +BEL,CBF3 Complex,000084,CBF3 +BEL,CCNA Family,000131,Cyclin_A +BEL,CCND Family,000132,Cyclin_D +BEL,CCNE Family,000133,Cyclin_E +BEL,CCT Complex,000085,CCT_complex +BEL,CD16 Family,000086,CD16 +BEL,CD3 Complex,000087,CD3 +BEL,CD32 Family,000088,CD32 +BEL,CD64 Family,000089,CD64 +BEL,CDC25 Family,000091,CDC25 +BEL,CDH Family,000074,Cadherin +BEL,CEBP Family,000097,CEBP +BEL,Chemokine Receptor Family,000100,Chemokine_receptor +BEL,Cholinesterase Family,000101,Cholinesterase +BEL,CHRM Family,000102,CHRM +BEL,CHRN Complex,000103,CHRN +BEL,CK II Complex,000104,CK2 +BEL,Clathrin Complex,000105,Clathrin +BEL,Cohesin Complex,000108,Cohesin +BEL,COL1 Family,000109,COL1 +BEL,COL4 Family,000110,COL4 +BEL,COL5 Family,000111,COL5 +BEL,COX4 Family,000114,COX4 +BEL,COX6A Family,000115,COX6A +BEL,COX6B Family,000116,COX6B +BEL,COX7A Family,000117,COX7A +BEL,COX7B Family,000118,COX7B +BEL,COX8 Family,000119,COX8 +BEL,CREB Family,000120,CREB +BEL,CRISP Family,000121,CRISP +BEL,CRSP Complex,000122,CRSP +BEL,CSNK1 Family,000124,CSNK1 +BEL,CSNK2 Family,000125,CSNK2 +BEL,CTNNA Family,000126,CTNNA +BEL,Cu-Zn SOD Family,000447,SOD +BEL,CUL Family,000127,CUL +BEL,CXCL ELR-Negative Family,000128,CXCL_ELR_negative +BEL,CXCL ELR-Positive Family,000129,CXCL_ELR_positive +BEL,Cyclophilin Family,000134,Cyclophilin +BEL,Cytochrome C Oxidase Complex Muscle,000113,COX +BEL,Cytochrome C Oxidase Complex Non Muscle,000113,COX +BEL,Cytoplasmic Dynein Complex,000135,Cytoplasmic_dynein +BEL,DDR Family,000136,DDR +BEL,Desmoglein Family,000138,Desmoglein +BEL,DGK Family,000140,DGK +BEL,DNA Polymerase delta Complex,000141,DNA_polymerase_delta +BEL,DNM Family,000142,DNM +BEL,DRD Family,000143,DRD +BEL,DVL Family,000145,DVL +BEL,Dystrophin Associated Glycoprotein Complex,000139,DGC +BEL,E2F Family,000147,E2F +BEL,EDN Family,000149,EDN +BEL,EGFR Ligand Family,000150,EGFR_ligand +BEL,EGFR/ERBB Family,000160,ERBB +BEL,EGR Family,000151,EGR +BEL,EIF2B Complex,000152,EIF2B +BEL,EIF4A Family,000153,EIF4A +BEL,EIF4EBP Family,000154,EIF4EBP +BEL,ELA Family,000156,ELA +BEL,ENO Family,000157,ENO +BEL,Ephrin Receptor Family,000158,Ephrin_receptor +BEL,EPN Family,000159,EPN +BEL,ESR Family,000162,ESR +BEL,ETS Family,000163,ETS +BEL,FGF Family,000167,FGF +BEL,FGFR Family,000168,FGFR +BEL,Fibrinogen Complex,000169,Fibrinogen +BEL,FLOT Family,000170,FLOT +BEL,FLRT Family,000171,FLRT +BEL,Follicle Stimulating Hormone Complex,000175,FSH +BEL,FOXO Family,000174,FOXO +BEL,FZD Family,000177,FZD +BEL,GABR Family,000179,GABR +BEL,gamma Secretase Complex,000181,Gamma_secretase +BEL,GAS6 Receptor Family,000183,GAS6_receptor +BEL,GATA Family,000184,GATA +BEL,GNA Gq Family,000215,G_q +BEL,GNA Gs Family,000217,G_s +BEL,GNAI Family,000212,G_i +BEL,GNB Family,000210,G_beta +BEL,GNG Family,000211,G_gamma +BEL,GPIT Complex,000189,GPIT +BEL,GPX Family,000190,GPX +BEL,GRIA Family,000191,GRIA +BEL,GRK Family,000192,GRK +BEL,GRM Family,000193,GRM +BEL,GSK3 Family,000194,GSK3 +BEL,GST Family,000195,GST +BEL,GTF2E Complex,000196,GTF2E +BEL,GTF2F Complex,000197,GTF2F +BEL,GUCY Family,000205,GUCY +BEL,GYS Family,000206,GYS +BEL,HDAC Class I Family,000221,HDAC_I +BEL,HDAC Class II Family,000222,HDAC_II +BEL,HDAC Family,000220,HDAC +BEL,HDL Complex,000225,HDL +BEL,Hedgehog Family,000226,Hedgehog +BEL,Hemoglobin Complex,000227,Hemoglobin +BEL,HES Family,000228,HES +BEL,Histone Family,000233,Histone +BEL,Histone H1 Family,000234,Histone_H1 +BEL,Histone H2A Family,000235,Histone_H2A +BEL,Histone H2B Family,000236,Histone_H2B +BEL,Histone H3 Family,000237,Histone_H3 +BEL,Histone H4 Family,000238,Histone_H4 +BEL,HLA-DR Family,000239,HLA_DR +BEL,HMOX Family,000240,HMOX +BEL,HSP90 Family,000241,HSP90 +BEL,HSPA Family,000244,HSPA +BEL,HSPB Family,000245,HSPB +BEL,Ib-V-IX Complex,000188,GPIb_IX_V +BEL,IFNA Family,000246,IFNA +BEL,IGFBP Family,000248,IGFBP +BEL,IkappaB Kinase Complex,000250,IKK_complex +BEL,IkappaB Kinase Family,000251,IKK_family +BEL,IL1 Family,000252,IL1 +BEL,INS Family,000259,INS +BEL,INSR Family,000260,INSR +BEL,Interferon Gamma Receptor Complex,000263,Interferon_gamma_receptor +BEL,IRS Family,000264,IRS +BEL,IRX Family,000265,IRX +BEL,JAK Family,000266,JAK +BEL,Kinetochore Complex,000270,Kinetochore +BEL,KLK Family,000271,KLK +BEL,Laminin 1 Complex,000273,Laminin_111 +BEL,Laminin 5 Complex,000274,Laminin_332 +BEL,LDH Family,000275,LDH +BEL,Luteinizing Hormone Complex,000276,LH +BEL,MAF Family,000279,MAF +BEL,MAPK Erk1/2 Family,000161,ERK +BEL,MAPK Erk1/3 Family,000161,ERK +BEL,MAPK JNK Family,000267,JNK +BEL,MAPK p38 Family,000326,p38 +BEL,MEF2 Family,000285,MEF2 +BEL,MEK1/2 Family,000286,MEK +BEL,Membrane Attack Complex,000278,MAC +BEL,MMP Family,000291,MMP +BEL,MYH Family,000295,MYH +BEL,MYL Alkali Family,000297,MYL_alkali +BEL,MYL Family,000296,MYL +BEL,MYL Regulatory Family,000298,MYL_regulatory +BEL,MYL Slow Family,000299,MYL_slow +BEL,MYST Family,000300,MYST +BEL,Na/K Exchanging ATPase Complex,000303,Na_K_ATPase +BEL,NADH Dehydrogenase Complex,000301,NADH_dehydrogenase +BEL,NADPH Oxidase Complex,000302,NADPH_oxidase +BEL,NCOR Family,000306,NCOR +BEL,NDRG Family,000307,NDRG +BEL,NFAT Family,000309,NFAT +BEL,Nfkb Complex,000311,NFkappaB +BEL,Nfy Complex,000314,NFY +BEL,NKD Family,000315,NKD +BEL,NOS Family,000316,NOS +BEL,NOTCH Family,000317,Notch +BEL,NRG1/2 Family,000319,NRG_1_2 +BEL,NRG3/4 Family,000320,NRG_3_4 +BEL,NTRK Family,000321,NTRK +BEL,p160/SRC Family,000305,NCOA +BEL,P2RX Family,000324,P2RX +BEL,P2RY Family,000325,P2RY +BEL,p85/p110 PI3Kinase Complex,000358,PI3K +BEL,PAK Family,000330,PAK +BEL,PARV Family,000332,PARV +BEL,PBX Family,000334,PBX +BEL,PDE Family,000335,PDE +BEL,PDE1 Family,000336,PDE1 +BEL,PDE3 Family,000337,PDE3 +BEL,PDE4 Family,000338,PDE4 +BEL,PDE6 Family,000339,PDE6 +BEL,PDGF Family,000342,PDGF +BEL,PDGFR Family,000343,PDGFR +BEL,PDK Family,000353,PDK +BEL,PFN Family,000355,PFN +BEL,Phosphorylase B Kinase Complex,000356,PhK +BEL,PIK3C Class IA Family,000359,PI3K_p110 +BEL,PIK3R Class IA Family,000361,PIK3R_I +BEL,PKI Family,000365,PKI +BEL,PLA2 Family,000366,PLA2 +BEL,PLA2G2 Family,000367,PLA2G2 +BEL,PLC Family,000369,PLC +BEL,PLCB Family,000370,PLCB +BEL,PLCG Family,000372,PLCG +BEL,PLD Family,000373,PLD +BEL,PPAP2 Family,000374,PPAP2 +BEL,PPAR Family,000375,PPAR +BEL,PPP1C Family,000377,PPP1C +BEL,PPP1R Family,000378,PPP1R +BEL,PPP2C Family,000380,PPP2C +BEL,PPP2R Subunit A Family,000381,PPP2R_A +BEL,PPP2R Subunit B Family,000382,PPP2R_B +BEL,PPP3 Family,000383,PPP3 +BEL,PPP3C Family,000384,PPP3C +BEL,PPP3R Family,000385,PPP3R +BEL,PRC1 Maintenance Complex,000386,PRC1_complex +BEL,PRC2 Initiation Complex,000387,PRC2_complex +BEL,PRDX Family,000388,PRDX +BEL,PRKA Family,000389,PRKAC +BEL,PRKAA Family,000044,AMPK_alpha +BEL,PRKAB Family,000045,AMPK_beta +BEL,PRKAG Family,000046,AMPK_gamma +BEL,PRKAR Family,000390,PRKAR +BEL,PRKC Family,000364,PKC +BEL,PRKG Family,000391,PRKG +BEL,Propionyl CoA Carboxylase Complex,000392,Propionyl_CoA_carboxylase +BEL,Proteasome Complex,000394,Proteasome +BEL,Proton Transporting ATP Synthase Complex,000060,ATP_synthase +BEL,PTGER Family,000395,PTGER +BEL,Pyruvate Dehydrogenase Complex,000352,PDH +BEL,RAB Family,000397,RAB +BEL,RAC Family,000398,RAC +BEL,RAF Family,000399,RAF +BEL,RAR Family,000403,RAR +BEL,RAS Family,000404,RAS +BEL,Respiratory Chain Complex II,000502,ETC_complex_II +BEL,Respiratory Chain Complex III,000503,ETC_complex_III +BEL,RFC Complex,000411,RFC +BEL,RFX Family,000412,RFX +BEL,RHO Family,000414,RHO +BEL,RNApo I Complex,000416,RNApo_I +BEL,RNApo II Complex,000417,RNApo_II +BEL,ROCK Family,000419,ROCK +BEL,ROR Family,000420,ROR +BEL,RPS6KA Family,000329,P90RSK +BEL,RPS6KB Family,000328,P70S6K +BEL,RXR Family,000424,RXR +BEL,S100A Family,000426,S100A +BEL,S1PR Family,000427,S1PR +BEL,SAA Family,000428,SAA +BEL,SCD Family,000429,SCD +BEL,SERPINB Family,000431,SERPINB +BEL,SLC2A Family,000434,SLC2A +BEL,SMAD Family,000441,SMAD +BEL,SMC1 Family,000444,SMC1 +BEL,SNAI Family,000446,SNAI +BEL,SOS Family,000448,SOS +BEL,SRC Family,000451,SRC +BEL,SREBF Family,000452,SREBF +BEL,STAT Family,000453,STAT +BEL,STAT5 Family,000454,STAT5 +BEL,Sulfonylurea Receptor Family,000456,Sulfonylurea_receptor +BEL,SWI/SNF Complex,000457,SWI_SNF +BEL,TAP Family,000459,TAP +BEL,TCF/LEF Family,000460,TCF_LEF +BEL,TFAP2 Family,000463,TFAP2 +BEL,TFDP Family,000464,TFDP +BEL,TGFB Family,000465,TGFB +BEL,THBS Family,000467,THBS +BEL,THR Family,000468,THR +BEL,Thrombin Antithrombin Complex,000469,Thrombin_antithrombin +BEL,TIF IB Complex,000471,TIF_IB +BEL,TN Family,000473,TN +BEL,TNFRSF Family,000475,TNFRSF +BEL,TOP2 Family,000476,TOP2 +BEL,TORC2 Complex,000294,mTORC2 +BEL,Tryptase Family,000481,Tryptase +BEL,TUBA Family,000483,TUBA +BEL,TUBB Family,000484,TUBB +BEL,TXN Family,000487,TXN +BEL,TXNRD Family,000488,TXNRD +BEL,UBE2 Family,000489,UBE2 +BEL,VAV Family,000494,VAV +BEL,VEGF Family,000495,VEGF +BEL,VEGFR Family,000496,VEGFR +BEL,WNT Family,000497,Wnt +COMPLEXPORTAL,CPX-560,000503,ETC_complex_III +COMPLEXPORTAL,CPX-561,000502,ETC_complex_II +COMPLEXPORTAL,CPX-577,000501,ETC_complex_I +ECCODE,1.1.1.1,000018,ADH +ECCODE,1.10.2.2,000503,ETC_complex_III +ECCODE,1.11.1.15,000388,PRDX +ECCODE,1.11.1.9,000190,GPX +ECCODE,1.14.19.1,000429,SCD +ECCODE,1.14.99.3,000240,HMOX +ECCODE,1.2.1.3,000024,ALDH +ECCODE,1.2.4.1,000353,PDK +ECCODE,1.3.5.1,000502,ETC_complex_II +ECCODE,1.3.8.7,000004,ACAD +ECCODE,1.6.5.3,000501,ETC_complex_I +ECCODE,1.6.5.3,000301,NADH_dehydrogenase +ECCODE,1.9.3.1,000113,COX +ECCODE,1.9.3.1,000504,ETC_complex_IV +ECCODE,2.3.2.23,000489,UBE2 +ECCODE,2.5.1.58,000172,FNT +ECCODE,2.7.1.107,000140,DGK +ECCODE,2.7.11.11,000363,PKA +ECCODE,2.7.11.12,000391,PRKG +ECCODE,2.7.11.13,000364,PKC +ECCODE,2.7.11.16,000192,GRK +ECCODE,2.7.11.17,000076,CAMK +ECCODE,2.7.11.19,000356,PhK +ECCODE,2.7.11.22,000092,CDK +ECCODE,2.7.11.24,000283,MAPK +ECCODE,2.7.11.25,000282,MAP3K +ECCODE,2.7.11.31,000031,AMPK +ECCODE,2.7.12.2,000283,MAPK +ECCODE,3.1.1.1,000080,Carboxylesterase +ECCODE,3.1.1.4,000366,PLA2 +ECCODE,3.1.4.-,000335,PDE +ECCODE,3.1.4.4,000373,PLD +ECCODE,3.4.21.35,000271,KLK +ECCODE,3.4.21.59,000481,Tryptase +ECCODE,3.4.25.1,000394,Proteasome +ECCODE,3.5.1.98,000220,HDAC +ECCODE,3.6.3.14,000505,ETC_complex_V +ECCODE,3.6.3.9,000303,Na_K_ATPase +ECCODE,3.6.5.-,000204,GTPase +ECCODE,4.1.2.13,000025,ALDO +ECCODE,4.6.1.2,000205,GUCY +ECCODE,6.4.1.2,000005,ACC +ECCODE,6.4.1.3,000392,Propionyl_CoA_carboxylase +GFAM,1199,000269,Kainate_family +GFAM,1582,000308,Neurexins +GO,GO:0000145,000164,EXOC +GO,GO:0000502,000394,Proteasome +GO,GO:0000776,000270,Kinetochore +GO,GO:0000930,000485,TUBG +GO,GO:0004117,000336,PDE1 +GO,GO:0004198,000079,CAPN +GO,GO:0004199,000081,Caspase +GO,GO:0004886,000424,RXR +GO,GO:0004890,000179,GABR +GO,GO:0004931,000324,P2RX +GO,GO:0004936,000019,ADRA +GO,GO:0004937,000019,ADRA +GO,GO:0004938,000020,ADRA2 +GO,GO:0004952,000143,DRD +GO,GO:0005007,000168,FGFR +GO,GO:0005035,000137,Death_receptor +GO,GO:0005094,000415,RhoGDI +GO,GO:0005096,000182,GAP +GO,GO:0005154,000150,EGFR_ligand +GO,GO:0005161,000342,PDGF +GO,GO:0005162,000167,FGF +GO,GO:0005172,000496,VEGFR +GO,GO:0005355,000434,SLC2A +GO,GO:0005577,000169,Fibrinogen +GO,GO:0005579,000278,MAC +GO,GO:0005584,000109,COL1 +GO,GO:0005587,000110,COL4 +GO,GO:0005588,000111,COL5 +GO,GO:0005610,000274,Laminin_332 +GO,GO:0005663,000411,RFC +GO,GO:0005665,000417,RNApo_II +GO,GO:0005673,000196,GTF2E +GO,GO:0005674,000197,GTF2F +GO,GO:0005680,000050,APC_C +GO,GO:0005736,000416,RNApo_I +GO,GO:0005747,000501,ETC_complex_I +GO,GO:0005749,000502,ETC_complex_II +GO,GO:0005750,000503,ETC_complex_III +GO,GO:0005751,000504,ETC_complex_IV +GO,GO:0005753,000505,ETC_complex_V +GO,GO:0005761,000288,Mitochondrial_Ribosome +GO,GO:0005762,000290,MRPL +GO,GO:0005763,000289,MRPS +GO,GO:0005832,000085,CCT_complex +GO,GO:0005861,000477,Troponin +GO,GO:0005868,000135,Cytoplasmic_dynein +GO,GO:0005884,000009,Actin +GO,GO:0005956,000104,CK2 +GO,GO:0008190,000154,EIF4EBP +GO,GO:0008278,000108,Cohesin +GO,GO:0008279,000108,Cohesin +GO,GO:0008281,000456,Sulfonylurea_receptor +GO,GO:0008433,000186,GEF +GO,GO:0008599,000376,PPP1 +GO,GO:0016010,000139,DGC +GO,GO:0016190,000105,Clathrin +GO,GO:0016904,000103,CHRN +GO,GO:0016914,000175,FSH +GO,GO:0019787,000489,UBE2 +GO,GO:0030122,000015,Adaptor_protein_II +GO,GO:0031518,000084,CBF3 +GO,GO:0031931,000293,mTORC1 +GO,GO:0031941,000178,F_actin +GO,GO:0032281,000191,GRIA +GO,GO:0034364,000225,HDL +GO,GO:0034666,000261,Integrins +GO,GO:0034683,000261,Integrins +GO,GO:0034687,000261,Integrins +GO,GO:0035098,000387,PRC2_complex +GO,GO:0035102,000386,PRC1_complex +GO,GO:0038036,000427,S1PR +GO,GO:0042555,000284,MCM +GO,GO:0042825,000459,TAP +GO,GO:0043509,000011,Activin_A +GO,GO:0043511,000256,Inhibin +GO,GO:0043625,000141,DNA_polymerase_delta +GO,GO:0045275,000503,ETC_complex_III +GO,GO:0048180,000010,Activin +GO,GO:0070652,000061,Augmin +GO,GO:0070765,000181,Gamma_secretase +GO,GO:1990779,000188,GPIb_IX_V +HGNC_GROUP,1149,000499,ETC_complex_I_core +HGNC_GROUP,1150,000500,ETC_complex_I_supernumerary +HGNC_GROUP,581,000061,Augmin +HGNC_GROUP,640,000501,ETC_complex_I +HGNC_GROUP,641,000502,ETC_complex_II +HGNC_GROUP,642,000503,ETC_complex_III +HGNC_GROUP,643,000504,ETC_complex_IV +HGNC_GROUP,644,000505,ETC_complex_V +IP,IPR000074,000052,Apolipoprotein +IP,IPR000096,000428,SAA +IP,IPR000162,000193,GRM +IP,IPR000164,000237,Histone_H3 +IP,IPR000239,000192,GRK +IP,IPR000308,000323,p14_3_3 +IP,IPR000320,000226,Hedgehog +IP,IPR000381,000013,Activin_B +IP,IPR000388,000456,Sulfonylurea_receptor +IP,IPR000406,000415,RhoGDI +IP,IPR000451,000311,NFkappaB +IP,IPR000454,000059,ATP5G +IP,IPR000469,000207,G_12 +IP,IPR000469,000208,G_12_alpha +IP,IPR000491,000011,Activin_A +IP,IPR000654,000215,G_q +IP,IPR000654,000216,G_q_alpha +IP,IPR000741,000025,ALDO +IP,IPR000751,000091,CDC25 +IP,IPR000756,000140,DGK +IP,IPR000889,000190,GPX +IP,IPR000929,000143,DRD +IP,IPR000941,000157,ENO +IP,IPR000995,000102,CHRM +IP,IPR000997,000101,Cholinesterase +IP,IPR001090,000158,Ephrin_receptor +IP,IPR001132,000441,SMAD +IP,IPR001154,000476,TOP2 +IP,IPR001208,000284,MCM +IP,IPR001217,000453,STAT +IP,IPR001241,000476,TOP2 +IP,IPR001349,000115,COX6A +IP,IPR001370,000066,BIRC +IP,IPR001408,000212,G_i +IP,IPR001408,000213,G_i_alpha +IP,IPR001426,000158,Ephrin_receptor +IP,IPR001429,000324,P2RX +IP,IPR001442,000110,COL4 +IP,IPR001522,000429,SCD +IP,IPR001612,000083,CAV +IP,IPR001657,000226,Hedgehog +IP,IPR001767,000226,Hedgehog +IP,IPR001770,000211,G_gamma +IP,IPR001928,000149,EDN +IP,IPR001951,000238,Histone_H4 +IP,IPR002051,000240,HMOX +IP,IPR002112,000268,JUN_family +IP,IPR002117,000327,p53_family +IP,IPR002138,000081,Caspase +IP,IPR002194,000085,CCT_complex +IP,IPR002205,000476,TOP2 +IP,IPR002209,000167,FGF +IP,IPR002374,000391,PRKG +IP,IPR002453,000484,TUBB +IP,IPR002454,000485,TUBG +IP,IPR002655,000007,ACOX +IP,IPR002717,000300,MYST +IP,IPR003000,000223,HDAC_III +IP,IPR003074,000375,PPAR +IP,IPR003084,000220,HDAC +IP,IPR003084,000221,HDAC_I +IP,IPR003113,000359,PI3K_p110 +IP,IPR003175,000095,CDKN1 +IP,IPR003205,000119,COX8 +IP,IPR003367,000467,THBS +IP,IPR003502,000252,IL1 +IP,IPR003586,000226,Hedgehog +IP,IPR003587,000226,Hedgehog +IP,IPR004000,000009,Actin +IP,IPR004030,000316,NOS +IP,IPR004061,000427,S1PR +IP,IPR004142,000307,NDRG +IP,IPR004171,000365,PKI +IP,IPR004203,000114,COX4 +IP,IPR004241,000280,MAP1LC3 +IP,IPR004766,000333,Patched +IP,IPR004826,000279,MAF +IP,IPR004979,000463,TFAP2 +IP,IPR005455,000355,PFN +IP,IPR005542,000334,PBX +IP,IPR005643,000268,JUN_family +IP,IPR005782,000430,SERCA +IP,IPR005817,000497,Wnt +IP,IPR006019,000432,SHC +IP,IPR006338,000488,TXNRD +IP,IPR006828,000045,AMPK_beta +IP,IPR008297,000317,Notch +IP,IPR008349,000161,ERK +IP,IPR008351,000267,JNK +IP,IPR008352,000326,p38 +IP,IPR008366,000309,NFAT +IP,IPR008433,000118,COX7B +IP,IPR008606,000154,EIF4EBP +IP,IPR008631,000206,GYS +IP,IPR008859,000467,THBS +IP,IPR009045,000226,Hedgehog +IP,IPR009123,000138,Desmoglein +IP,IPR010011,000305,NCOA +IP,IPR010660,000317,Notch +IP,IPR010991,000327,p53_family +IP,IPR011039,000197,GTF2F +IP,IPR011615,000327,p53_family +IP,IPR011656,000317,Notch +IP,IPR012144,000316,NOS +IP,IPR012198,000390,PRKAR +IP,IPR012233,000364,PKC +IP,IPR012290,000169,Fibrinogen +IP,IPR012345,000453,STAT +IP,IPR012542,000476,TOP2 +IP,IPR013019,000441,SMAD +IP,IPR013288,000114,COX4 +IP,IPR013506,000476,TOP2 +IP,IPR013537,000005,ACC +IP,IPR013543,000077,CAMK2_complex +IP,IPR013543,000078,CAMK2_family +IP,IPR013558,000460,TCF_LEF +IP,IPR013706,000336,PDE1 +IP,IPR013757,000476,TOP2 +IP,IPR013758,000476,TOP2 +IP,IPR013759,000476,TOP2 +IP,IPR013760,000476,TOP2 +IP,IPR013790,000441,SMAD +IP,IPR013799,000453,STAT +IP,IPR013800,000453,STAT +IP,IPR013801,000453,STAT +IP,IPR013854,000463,TFAP2 +IP,IPR013871,000121,CRISP +IP,IPR014788,000101,Cholinesterase +IP,IPR014920,000305,NCOA +IP,IPR014935,000305,NCOA +IP,IPR014936,000062,AXIN +IP,IPR015008,000419,ROCK +IP,IPR015015,000003,ABL_family +IP,IPR015451,000132,Cyclin_D +IP,IPR015583,000349,PDGF_BB +IP,IPR015588,000247,IFNB +IP,IPR015615,000465,TGFB +IP,IPR015633,000147,E2F +IP,IPR015679,000373,PLD +IP,IPR015876,000429,SCD +IP,IPR015988,000453,STAT +IP,IPR016053,000240,HMOX +IP,IPR016072,000084,CBF3 +IP,IPR016084,000240,HMOX +IP,IPR016239,000329,P90RSK +IP,IPR016245,000160,ERBB +IP,IPR016246,000260,INSR +IP,IPR016247,000420,ROR +IP,IPR016248,000168,FGFR +IP,IPR016251,000266,JAK +IP,IPR016257,000158,Ephrin_receptor +IP,IPR016279,000372,PLCG +IP,IPR016280,000370,PLCB +IP,IPR016311,000163,ETS +IP,IPR016319,000465,TGFB +IP,IPR016346,000210,G_beta +IP,IPR016897,000084,CBF3 +IP,IPR017104,000049,AP2A +IP,IPR017348,000362,PIM +IP,IPR017426,000305,NCOA +IP,IPR017897,000467,THBS +IP,IPR017904,000107,Cofilin +IP,IPR018161,000497,Wnt +IP,IPR018207,000240,HMOX +IP,IPR018361,000083,CAV +IP,IPR018507,000115,COX6A +IP,IPR018522,000476,TOP2 +IP,IPR019764,000149,EDN +IP,IPR020475,000149,EDN +IP,IPR020537,000059,ATP5G +IP,IPR020684,000419,ROCK +IP,IPR020777,000321,NTRK +IP,IPR020810,000157,ENO +IP,IPR020811,000157,ENO +IP,IPR022684,000079,CAPN +IP,IPR023272,000118,COX7B +IP,IPR023337,000449,SPRED +IP,IPR023409,000323,p14_3_3 +IP,IPR023410,000323,p14_3_3 +IP,IPR024940,000460,TCF_LEF +IP,IPR024946,000476,TOP2 +IP,IPR025561,000272,KSR +IP,IPR026590,000223,HDAC_III +IP,IPR027288,000346,PDGFR_BB +IP,IPR027290,000344,PDGFR_AA +IP,IPR027309,000324,P2RX +IP,IPR027705,000170,FLOT +IP,IPR027707,000480,Troponin_T +IP,IPR027936,000158,Ephrin_receptor +IP,IPR028412,000400,RAL +IP,IPR028433,000332,PARV +IP,IPR028858,000133,Cyclin_E +IP,IPR028974,000467,THBS +IP,IPR028992,000226,Hedgehog +IP,IPR029760,000190,GPX +IP,IPR029768,000025,ALDO +IP,IPR030492,000311,NFkappaB +IP,IPR031327,000284,MCM +IP,IPR031635,000321,NTRK +IP,IPR031660,000476,TOP2 +IP,IPR031675,000377,PPP1C +IP,IPR031905,000170,FLOT +IP,IPR032067,000174,FOXO +IP,IPR032101,000062,AXIN +IP,IPR032270,000044,AMPK_alpha +IP,IPR032640,000045,AMPK_beta +IP,IPR033139,000081,Caspase +IP,IPR033614,000410,RASSF +IP,IPR033896,000285,MEF2 +IP,IPR033923,000330,PAK +IP,IPR033926,000311,NFkappaB +IP,IPR034117,000121,CRISP +IP,IPR034157,000476,TOP2 +IP,IPR035014,000391,PRKG +IP,IPR035023,000372,PLCG +IP,IPR035024,000372,PLCG +MEDSCAN,urn:agi-aopfc:0000094,000120,CREB +MEDSCAN,urn:agi-aopfc:0000099,000147,E2F +MEDSCAN,urn:agi-aopfc:0000105,000184,GATA +MEDSCAN,urn:agi-aopfc:0000142,000279,MAF +MEDSCAN,urn:agi-aopfc:0000143,000285,MEF2 +MEDSCAN,urn:agi-aopfc:0000150,000310,NFE +MEDSCAN,urn:agi-aopfc:0000156,000311,NFkappaB +MEDSCAN,urn:agi-aopfc:0000157,000412,RFX +MEDSCAN,urn:agi-aopfc:0000159,000441,SMAD +MEDSCAN,urn:agi-aopfc:0000163,000453,STAT +MEDSCAN,urn:agi-aopfc:0000197,000177,FZD +MEDSCAN,urn:agi-aopfc:0000252,000136,DDR +MEDSCAN,urn:agi-aopfc:0000264,000260,INSR +MEDSCAN,urn:agi-aopfc:0000278,000321,NTRK +MEDSCAN,urn:agi-aopfc:0000279,000317,Notch +MEDSCAN,urn:agi-aopfc:0000281,000333,Patched +MEDSCAN,urn:agi-aopfc:0000286,000420,ROR +MEDSCAN,urn:agi-aopfc:0000294,000466,TGFBR +MEDSCAN,urn:agi-aopfc:0000295,000475,TNFRSF +MEDSCAN,urn:agi-aopfc:0000296,000472,TLR +MEDSCAN,urn:agi-aopfc:0000311,000187,GPCR +MEDSCAN,urn:agi-aopfc:0000391,000099,Chemokine +MEDSCAN,urn:agi-aopfc:0000423,000465,TGFB +MEDSCAN,urn:agi-aopfc:0000426,000497,Wnt +MEDSCAN,urn:agi-aopfc:0000434,000194,GSK3 +MEDSCAN,urn:agi-aopfc:0000439,000023,AKT +MEDSCAN,urn:agi-aopfc:0000447,000358,PI3K +MEDSCAN,urn:agi-aopfc:0000452,000075,CALM +MEDSCAN,urn:agi-aopfc:0000455,000366,PLA2 +MEDSCAN,urn:agi-aopfc:0000458,000161,ERK +MEDSCAN,urn:agi-aopfc:0000462,000286,MEK +MEDSCAN,urn:agi-aopfc:0000464,000266,JAK +MEDSCAN,urn:agi-aopfc:0000465,000404,RAS +MEDSCAN,urn:agi-aopfc:0000468,000330,PAK +MEDSCAN,urn:agi-aopfc:0000473,000267,JNK +MEDSCAN,urn:agi-aopfc:0000477,000326,p38 +MEDSCAN,urn:agi-aopfc:0000479,000302,NADPH_oxidase +MEDSCAN,urn:agi-aopfc:0000494,000316,NOS +MEDSCAN,urn:agi-aopfc:0000499,000414,RHO +MEDSCAN,urn:agi-aopfc:0000504,000494,VAV +MEDSCAN,urn:agi-aopfc:0000509,000451,SRC +MEDSCAN,urn:agi-aopfc:0000551,000091,CDC25 +MEDSCAN,urn:agi-aopfc:0000567,000003,ABL_family +MEDSCAN,urn:agi-aopfc:0000571,000050,APC_C +MEDSCAN,urn:agi-aopfc:0000585,000264,IRS +MEDSCAN,urn:agi-aopfc:0000586,000248,IGFBP +MEDSCAN,urn:agi-aopfc:0000587,000226,Hedgehog +MEDSCAN,urn:agi-aopfc:0000615,000252,IL1 +MEDSCAN,urn:agi-aopfc:0000704,000339,PDE6 +MEDSCAN,urn:agi-complex:CaM%20kinase%20II,000077,CAMK2_complex +MEDSCAN,urn:agi-complex:CD3%20complex,000087,CD3 +MEDSCAN,urn:agi-complex:CD8,000090,CD8 +MEDSCAN,urn:agi-complex:HIF-1,000230,HIF1 +MEDSCAN,urn:agi-complex:IFNGR,000263,Interferon_gamma_receptor +MEDSCAN,urn:agi-complex:IKK%20complex,000250,IKK_complex +MEDSCAN,urn:agi-complex:IL12,000253,IL12 +MEDSCAN,urn:agi-complex:inhibin%20A,000257,Inhibin_A +MEDSCAN,urn:agi-complex:Luteinizing%20hormone,000276,LH +MEDSCAN,urn:agi-complex:MAC-1%20(integrin),000261,Integrins +MEDSCAN,urn:agi-complex:NF-E2,000310,NFE +MEDSCAN,urn:agi-complex:platelet%20derived%20growth%20factor%20AA,000347,PDGF_AA +MEDSCAN,urn:agi-complex:platelet%20derived%20growth%20factor%20AB,000348,PDGF_AB +MEDSCAN,urn:agi-complex:platelet%20derived%20growth%20factor%20BB,000349,PDGF_BB +MEDSCAN,urn:agi-complex:prophash-047b61fab6d7e7445346cc84dafcb267,000177,FZD +MEDSCAN,urn:agi-complex:prophash-0d528c29d63997f87f62e4fbd9f0b168,000294,mTORC2 +MEDSCAN,urn:agi-complex:prophash-0f8242e28423189d7ef714808fdcc121,000233,Histone +MEDSCAN,urn:agi-complex:prophash-285b9ff3749679e4d6266406a20973aa,000358,PI3K +MEDSCAN,urn:agi-complex:prophash-2b612daa76feb2db86ff39e70449df6b,000387,PRC2_complex +MEDSCAN,urn:agi-complex:prophash-2de597c3f4a807f3caeaf02e5f93ce15,000453,STAT +MEDSCAN,urn:agi-complex:prophash-40bc2e4348830d6f7bdacd573fd7c388,000147,E2F +MEDSCAN,urn:agi-complex:prophash-44f61960049704dc2afb23ff7c324b85,000230,HIF1 +MEDSCAN,urn:agi-complex:prophash-4dda466320b1a32b046d823accadbaee,000092,CDK +MEDSCAN,urn:agi-complex:prophash-50bd08479c3770278693a51fe379babd,000490,Ubiquitin +MEDSCAN,urn:agi-complex:prophash-72ef5fc0ab431a39e0e2915bf55b6e28,000441,SMAD +MEDSCAN,urn:agi-complex:prophash-7629c2cdfdf4908b72f13917a7c1551e,000411,RFC +MEDSCAN,urn:agi-complex:prophash-763d31b31e177311583df0ac1ea015da,000187,GPCR +MEDSCAN,urn:agi-complex:prophash-7e8823afb9ca7870b95633dcb782500b,000220,HDAC +MEDSCAN,urn:agi-complex:prophash-8a9e47ee0ee03d8d8b6e029e2fba6896,000074,Cadherin +MEDSCAN,urn:agi-complex:prophash-8cfce9bfac3857e6f068d517deadfeaa,000311,NFkappaB +MEDSCAN,urn:agi-complex:prophash-8d885376e30916afd0b47ccf1b044e75,000268,JUN_family +MEDSCAN,urn:agi-complex:prophash-90a087d4e73b3992c65edfd9f71c6802,000486,Tubulin +MEDSCAN,urn:agi-complex:prophash-9e456bf1de2c5eb1107156c96a1450e6,000466,TGFBR +MEDSCAN,urn:agi-complex:prophash-aba0c4130764ae7a26054736114e65cd,000386,PRC1_complex +MEDSCAN,urn:agi-complex:prophash-bd459ca2937257c9e3f2b75abf22f422,000424,RXR +MEDSCAN,urn:agi-complex:prophash-c3bac0781a4430da4cf6721b8f7537d9,000127,CUL +MEDSCAN,urn:agi-complex:prophash-cd6413d79122d5489ee4b4e339245b61,000085,CCT_complex +MEDSCAN,urn:agi-complex:prophash-d39afef40daf23ad8376b53904c7092c,000376,PPP1 +MEDSCAN,urn:agi-complex:prophash-d9fbae788d60df23b6be4a3ead2cbab4,000417,RNApo_II +MEDSCAN,urn:agi-complex:prophash-dd63d0a558770b12c9149b4955828f35,000050,APC_C +MEDSCAN,urn:agi-complex:prophash-e4ec238e69c3d3292966ac97dbc11086,000477,Troponin +MEDSCAN,urn:agi-complex:prophash-e6be10f6a8e79aed1daa4ec2ac191db1,000284,MCM +MEDSCAN,urn:agi-complex:prophash-e9fbfd73e486bda4d99b348f72bb4196,000204,GTPase +MEDSCAN,urn:agi-complex:prophash-f2e03d3bf1f747adab17ce77b9b5e5b3,000379,PPP2 +MEDSCAN,urn:agi-complex:prophash-f472fef3f59301aee0b776702a30f03e,000293,mTORC1 +MEDSCAN,urn:agi-complex:prophash-f7a9dc05e48afd7a93466cfbd5504861,000457,SWI_SNF +MEDSCAN,urn:agi-complex:prophash-f7e292d6e30998b81cf5f772ab430f11,000075,CALM +MEDSCAN,urn:agi-complex:protein%20phosphatase%203,000383,PPP3 +MEDSCAN,urn:agi-complex:protein%20phosphatase%20type%201%20complex,000376,PPP1 +MEDSCAN,urn:agi-complex:protein%20phosphatase%20type%202A%20complex,000379,PPP2 +MEDSCAN,urn:agi-complex:SMAD2%2f3,000443,SMAD2_3 +MEDSCAN,urn:agi-protfc:14-3-3,000323,p14_3_3 +MEDSCAN,urn:agi-protfc:actins,000009,Actin +MEDSCAN,urn:agi-protfc:AMPK,000031,AMPK +MEDSCAN,urn:agi-protfc:apolipoprotein,000052,Apolipoprotein +MEDSCAN,urn:agi-protfc:bone%20morphogenetic%20protein%20I%20receptor,000069,BMP_receptor_type_I +MEDSCAN,urn:agi-protfc:cadherin,000074,Cadherin +MEDSCAN,urn:agi-protfc:casein%20kinase%20I,000124,CSNK1 +MEDSCAN,urn:agi-protfc:caveolin,000083,CAV +MEDSCAN,urn:agi-protfc:checkpoint%20kinase,000098,CHEK +MEDSCAN,urn:agi-protfc:chromatin%20remodeling%20complex,000457,SWI_SNF +MEDSCAN,urn:agi-protfc:class%20c%20orphan%20receptor,000187,GPCR +MEDSCAN,urn:agi-protfc:cullin,000127,CUL +MEDSCAN,urn:agi-protfc:cyclin,000130,Cyclin +MEDSCAN,urn:agi-protfc:cyclophilins,000134,Cyclophilin +MEDSCAN,urn:agi-protfc:cytosolic%20phospholipase%20a2,000366,PLA2 +MEDSCAN,urn:agi-protfc:desmoglein,000138,Desmoglein +MEDSCAN,urn:agi-protfc:endothelin,000149,EDN +MEDSCAN,urn:agi-protfc:F-actin-binding%20protein,000178,F_actin +MEDSCAN,urn:agi-protfc:flotillin,000170,FLOT +MEDSCAN,urn:agi-protfc:hemoglobin,000227,Hemoglobin +MEDSCAN,urn:agi-protfc:histone%20H1,000234,Histone_H1 +MEDSCAN,urn:agi-protfc:histone%20H2A,000235,Histone_H2A +MEDSCAN,urn:agi-protfc:histone%20H2B,000236,Histone_H2B +MEDSCAN,urn:agi-protfc:histone%20H3,000237,Histone_H3 +MEDSCAN,urn:agi-protfc:histone%20H4,000238,Histone_H4 +MEDSCAN,urn:agi-protfc:histone,000233,Histone +MEDSCAN,urn:agi-protfc:interferon,000262,Interferon +MEDSCAN,urn:agi-protfc:kallikrein,000271,KLK +MEDSCAN,urn:agi-protfc:mglur,000193,GRM +MEDSCAN,urn:agi-protfc:myosin%20heavy%20chain,000295,MYH +MEDSCAN,urn:agi-protfc:myosin%20light%20chain,000296,MYL +MEDSCAN,urn:agi-protfc:neuregulin%20family,000318,NRG +MEDSCAN,urn:agi-protfc:p2y%20receptor,000325,P2RY +MEDSCAN,urn:agi-protfc:p70rsk,000328,P70S6K +MEDSCAN,urn:agi-protfc:p90rsk,000329,P90RSK +MEDSCAN,urn:agi-protfc:PDE4%20subfamily,000338,PDE4 +MEDSCAN,urn:agi-protfc:phosphodiesterase%20III,000337,PDE3 +MEDSCAN,urn:agi-protfc:ppar,000375,PPAR +MEDSCAN,urn:agi-protfc:profilin,000355,PFN +MEDSCAN,urn:agi-protfc:rab,000397,RAB +MEDSCAN,urn:agi-protfc:sarcoplasmic%20reticulum%20calcium%20transporting%20adenosine%20triphosphatase,000430,SERCA +MEDSCAN,urn:agi-protfc:shc%20protein,000432,SHC +MEDSCAN,urn:agi-protfc:STAT5%20protein,000454,STAT5 +MEDSCAN,urn:agi-protfc:sterol%20regulatory%20element%20binding%20protein,000452,SREBF +MEDSCAN,urn:agi-protfc:SWI%2fSNF%20family,000457,SWI_SNF +MEDSCAN,urn:agi-protfc:thioredoxin,000487,TXN +MEDSCAN,urn:agi-protfc:thrombospondins,000467,THBS +MEDSCAN,urn:agi-protfc:tubulin,000486,Tubulin +MEDSCAN,urn:agi-protfc:ubiquitin,000490,Ubiquitin +MESH,C072194,000349,PDGF_BB +MESH,D000199,000009,Actin +MESH,D003576,000504,ETC_complex_IV +MESH,D006657,000233,Histone +MESH,D010749,000357,Phosphatase +MESH,D011493,000364,PKC +MESH,D011948,000461,TCR +MESH,D014450,000503,ETC_complex_III +MESH,D016695,000198,Glycosyltransferase +MESH,D018808,000048,AP1 +MESH,D018844,000092,CDK +MESH,D020169,000081,Caspase +MESH,D025261,000505,ETC_complex_V +MESH,D042963,000502,ETC_complex_II +MESH,D042967,000501,ETC_complex_I +MESH,D046988,000394,Proteasome +NCIT,C104194,000132,Cyclin_D +NCIT,C104197,000133,Cyclin_E +NCIT,C104199,000251,IKK_family +NCIT,C104676,000473,TN +NCIT,C105947,000281,MAP2K +NCIT,C105952,000051,APOA +NCIT,C107433,000338,PDE4 +NCIT,C107559,000104,CK2 +NCIT,C112049,000502,ETC_complex_II +NCIT,C112051,000080,Carboxylesterase +NCIT,C113839,000229,HIF +NCIT,C116019,000044,AMPK_alpha +NCIT,C118184,000501,ETC_complex_I +NCIT,C118481,000024,ALDH +NCIT,C118892,000174,FOXO +NCIT,C120030,000481,Tryptase +NCIT,C120493,000226,Hedgehog +NCIT,C124129,000109,COL1 +NCIT,C126114,000372,PLCG +NCIT,C126122,000188,GPIb_IX_V +NCIT,C129655,000484,TUBB +NCIT,C16258,000009,Actin +NCIT,C16264,000017,ADCY +NCIT,C16272,000018,ADH +NCIT,C16373,000074,Cadherin +NCIT,C16375,000075,CALM +NCIT,C16376,000161,ERK +NCIT,C16376,000283,MAPK +NCIT,C16377,000079,CAPN +NCIT,C16448,000110,COL4 +NCIT,C16479,000363,PKA +NCIT,C16511,000141,DNA_polymerase_delta +NCIT,C16641,000195,GST +NCIT,C16650,000204,GTPase +NCIT,C16653,000205,GUCY +NCIT,C16676,000227,Hemoglobin +NCIT,C16682,000220,HDAC +NCIT,C16683,000234,Histone_H1 +NCIT,C16684,000235,Histone_H2A +NCIT,C16685,000237,Histone_H3 +NCIT,C16686,000238,Histone_H4 +NCIT,C16687,000233,Histone +NCIT,C16692,000239,HLA_DR +NCIT,C16748,000261,Integrins +NCIT,C16965,000393,Protease +NCIT,C16979,000366,PLA2 +NCIT,C16981,000357,Phosphatase +NCIT,C17017,000364,PKC +NCIT,C17061,000404,RAS +NCIT,C17062,000021,ADRB +NCIT,C17065,000461,TCR +NCIT,C17066,000143,DRD +NCIT,C17078,000468,THR +NCIT,C17219,000486,Tubulin +NCIT,C17227,000490,Ubiquitin +NCIT,C17270,000358,PI3K +NCIT,C17274,000067,BMP +NCIT,C17286,000120,CREB +NCIT,C17293,000496,VEGFR +NCIT,C17297,000168,FGFR +NCIT,C17298,000182,GAP +NCIT,C17322,000343,PDGFR +NCIT,C17343,000479,Troponin_I +NCIT,C17349,000130,Cyclin +NCIT,C17380,000311,NFkappaB +NCIT,C17450,000048,AP1 +NCIT,C17458,000214,G_protein +NCIT,C17487,000086,CD16 +NCIT,C17494,000186,GEF +NCIT,C17532,000403,RAR +NCIT,C17534,000424,RXR +NCIT,C17583,000249,IKB +NCIT,C17660,000423,RTK +NCIT,C17690,000230,HIF1 +NCIT,C17763,000160,ERBB +NCIT,C17766,000241,HSP90 +NCIT,C17767,000092,CDK +NCIT,C17903,000309,NFAT +NCIT,C18153,000081,Caspase +NCIT,C18162,000152,EIF2B +NCIT,C18164,000291,MMP +NCIT,C18239,000187,GPCR +NCIT,C18308,000088,CD32 +NCIT,C18434,000476,TOP2 +NCIT,C18492,000094,CDKN +NCIT,C18606,000158,Ephrin_receptor +NCIT,C19275,000213,G_i_alpha +NCIT,C19618,000453,STAT +NCIT,C19836,000368,PLA2G4 +NCIT,C19866,000386,PRC1_complex +NCIT,C20448,000342,PDGF +NCIT,C129646,000495,VEGF +NCIT,C20456,000010,Activin +NCIT,C20466,000099,Chemokine +NCIT,C20493,000262,Interferon +NCIT,C20495,000247,IFNB +NCIT,C20506,000252,IL1 +NCIT,C20514,000253,IL12 +NCIT,C20591,000457,SWI_SNF +NCIT,C2275,000219,hCG +NCIT,C2276,000256,Inhibin +NCIT,C2277,000257,Inhibin_A +NCIT,C2278,000258,Inhibin_B +NCIT,C25184,000275,LDH +NCIT,C25186,000225,HDL +NCIT,C26034,000504,ETC_complex_IV +NCIT,C26233,000192,GRK +NCIT,C26360,000161,ERK +NCIT,C28687,000122,CRSP +NCIT,C38041,000480,Troponin_T +NCIT,C38897,000087,CD3 +NCIT,C41625,000023,AKT +NCIT,C736,000354,Pertussis_toxin +NCIT,C94701,000031,AMPK +NCIT,C95114,000181,Gamma_secretase +NCIT,C95947,000416,RNApo_I +NCIT,C95948,000417,RNApo_II +NCIT,C96314,000293,mTORC1 +NCIT,C96315,000294,mTORC2 +NXP,FA:00078,000009,Actin +NXP,FA:00093,000004,ACAD +NXP,FA:00209,000463,TFAP2 +NXP,FA:00406,000097,CEBP +NXP,FA:00408,000173,FOS_family +NXP,FA:00421,000385,PPP3R +NXP,FA:00440,000075,CALM +NXP,FA:00489,000083,CAV +NXP,FA:00653,000106,CNKSR +NXP,FA:00787,000127,CUL +NXP,FA:00803,000337,PDE3 +NXP,FA:00804,000338,PDE4 +NXP,FA:00815,000130,Cyclin +NXP,FA:00818,000132,Cyclin_D +NXP,FA:00819,000133,Cyclin_E +NXP,FA:00921,000153,EIF4A +NXP,FA:01112,000157,ENO +NXP,FA:01121,000159,EPN +NXP,FA:01400,000211,G_gamma +NXP,FA:01553,000190,GPX +NXP,FA:01669,000195,GST +NXP,FA:01729,000226,Hedgehog +NXP,FA:01762,000235,Histone_H2A +NXP,FA:01764,000237,Histone_H3 +NXP,FA:01765,000238,Histone_H4 +NXP,FA:01820,000252,IL1 +NXP,FA:01869,000259,INS +NXP,FA:02022,000275,LDH +NXP,FA:02159,000434,SLC2A +NXP,FA:02187,000284,MCM +NXP,FA:02504,000316,NOS +NXP,FA:02506,000317,Notch +NXP,FA:02630,000324,P2RX +NXP,FA:02632,000327,p53_family +NXP,FA:02660,000332,PARV +NXP,FA:02762,000156,ELA +NXP,FA:02767,000481,Tryptase +NXP,FA:02840,000366,PLA2 +NXP,FA:03001,000376,PPP1 +NXP,FA:03065,000364,PKC +NXP,FA:03066,000398,RAC +NXP,FA:03071,000031,AMPK +NXP,FA:03072,000076,CAMK +NXP,FA:03078,000362,PIM +NXP,FA:03083,000124,CSNK1 +NXP,FA:03087,000194,GSK3 +NXP,FA:03091,000146,DYRK +NXP,FA:03101,000104,CK2 +NXP,FA:03104,000251,IKK_family +NXP,FA:03114,000399,RAF +NXP,FA:03124,000158,Ephrin_receptor +NXP,FA:03128,000260,INSR +NXP,FA:03129,000266,JAK +NXP,FA:03130,000420,ROR +NXP,FA:03131,000451,SRC +NXP,FA:03483,000428,SAA +NXP,FA:03579,000431,SERPINB +NXP,FA:03661,000397,RAB +NXP,FA:03663,000404,RAS +NXP,FA:03668,000414,RHO +NXP,FA:03672,000435,SLRP +NXP,FA:03673,000436,SLRP_1 +NXP,FA:03674,000437,SLRP_2 +NXP,FA:03675,000438,SLRP_3 +NXP,FA:03676,000439,SLRP_4 +NXP,FA:03677,000440,SLRP_5 +NXP,FA:03686,000444,SMC1 +NXP,FA:03943,000460,TCF_LEF +NXP,FA:03964,000473,TN +NXP,FA:03989,000465,TGFB +NXP,FA:04000,000487,TXN +NXP,FA:04014,000470,TIAM +NXP,FA:04239,000486,Tubulin +NXP,FA:04243,000474,TNF +NXP,FA:04276,000490,Ubiquitin +NXP,FA:04282,000489,UBE2 +NXP,FA:04686,000497,Wnt +NXP,FA:04773,000401,RAP1 +PF,PF00012,000244,HSPA +PF,PF00022,000009,Actin +PF,PF00028,000074,Cadherin +PF,PF00066,000317,Notch +PF,PF00071,000404,RAS +PF,PF00110,000497,Wnt +PF,PF00143,000262,Interferon +PF,PF00146,000301,NADH_dehydrogenase +PF,PF00167,000167,FGF +PF,PF00178,000163,ETS +PF,PF00183,000241,HSP90 +PF,PF00219,000248,IGFBP +PF,PF00229,000474,TNF +PF,PF00235,000355,PFN +PF,PF00244,000323,p14_3_3 +PF,PF00255,000190,GPX +PF,PF00277,000428,SAA +PF,PF00320,000184,GATA +PF,PF00322,000149,EDN +PF,PF00340,000252,IL1 +PF,PF00465,000018,ADH +PF,PF00493,000284,MCM +PF,PF00503,000209,G_alpha +PF,PF00616,000407,RasGAP +PF,PF00644,000331,PARP +PF,PF00656,000081,Caspase +PF,PF00864,000324,P2RX +PF,PF00870,000327,p53_family +PF,PF00888,000127,CUL +PF,PF00963,000108,Cohesin +PF,PF01146,000083,CAV +PF,PF01442,000052,Apolipoprotein +PF,PF01534,000177,FZD +PF,PF01756,000007,ACOX +PF,PF02046,000115,COX6A +PF,PF02158,000318,NRG +PF,PF02174,000264,IRS +PF,PF02234,000094,CDKN +PF,PF02238,000117,COX7A +PF,PF02285,000119,COX8 +PF,PF02297,000116,COX6B +PF,PF02377,000145,DVL +PF,PF02460,000333,Patched +PF,PF02545,000279,MAF +PF,PF02608,000067,BMP +PF,PF02827,000365,PKI +PF,PF02854,000155,EIF4G +PF,PF02936,000114,COX4 +PF,PF03039,000253,IL12 +PF,PF03096,000307,NDRG +PF,PF05392,000118,COX7B +PF,PF08137,000145,DVL +PF,PF08562,000121,CRISP +PF,PF08841,000136,DDR +PF,PF11413,000230,HIF1 +PF,PF12483,000148,E3_Ub_ligase +PF,PF15975,000170,FLOT +RE,R-HSA-1031694,000089,CD64 +RE,R-HSA-109631,000197,GTF2F +RE,R-HSA-109633,000196,GTF2E +RE,R-HSA-109782,000404,RAS +RE,R-HSA-109783,000404,RAS +RE,R-HSA-109796,000404,RAS +RE,R-HSA-111854,000370,PLCB +RE,R-HSA-111864,000212,G_i +RE,R-HSA-111864,000213,G_i_alpha +RE,R-HSA-111921,000390,PRKAR +RE,R-HSA-111923,000390,PRKAR +RE,R-HSA-111952,000336,PDE1 +RE,R-HSA-111953,000336,PDE1 +RE,R-HSA-111960,000338,PDE4 +RE,R-HSA-114525,000208,G_12_alpha +RE,R-HSA-114534,000215,G_q +RE,R-HSA-114534,000216,G_q_alpha +RE,R-HSA-114547,000207,G_12 +RE,R-HSA-114556,000215,G_q +RE,R-HSA-114556,000216,G_q_alpha +RE,R-HSA-114617,000169,Fibrinogen +RE,R-HSA-114618,000169,Fibrinogen +RE,R-HSA-114657,000465,TGFB +RE,R-HSA-114668,000188,GPIb_IX_V +RE,R-HSA-1168365,000372,PLCG +RE,R-HSA-1168621,000250,IKK_complex +RE,R-HSA-1169086,000372,PLCG +RE,R-HSA-1169089,000372,PLCG +RE,R-HSA-1218829,000243,HSP90AA +RE,R-HSA-1221657,000243,HSP90AA +RE,R-HSA-1227956,000319,NRG_1_2 +RE,R-HSA-1227957,000318,NRG +RE,R-HSA-1234130,000229,HIF +RE,R-HSA-1234147,000231,HIF_alpha +RE,R-HSA-1236898,000089,CD64 +RE,R-HSA-1236905,000089,CD64 +RE,R-HSA-1247495,000319,NRG_1_2 +RE,R-HSA-1248743,000319,NRG_1_2 +RE,R-HSA-1250100,000326,p38 +RE,R-HSA-1250102,000326,p38 +RE,R-HSA-1268261,000161,ERK +RE,R-HSA-1362227,000464,TFDP +RE,R-HSA-139848,000324,P2RX +RE,R-HSA-139933,000169,Fibrinogen +RE,R-HSA-139934,000169,Fibrinogen +RE,R-HSA-140586,000169,Fibrinogen +RE,R-HSA-140812,000469,Thrombin_antithrombin +RE,R-HSA-140871,000469,Thrombin_antithrombin +RE,R-HSA-140874,000469,Thrombin_antithrombin +RE,R-HSA-140919,000169,Fibrinogen +RE,R-HSA-1445138,000323,p14_3_3 +RE,R-HSA-1449672,000013,Activin_B +RE,R-HSA-1449688,000256,Inhibin +RE,R-HSA-1449698,000012,Activin_AB +RE,R-HSA-1469978,000454,STAT5 +RE,R-HSA-1504201,000145,DVL +RE,R-HSA-157462,000133,Cyclin_E +RE,R-HSA-162690,000189,GPIT +RE,R-HSA-163538,000377,PPP1C +RE,R-HSA-163679,000042,AMPK_A2B2G2 +RE,R-HSA-163736,000042,AMPK_A2B2G2 +RE,R-HSA-163747,000042,AMPK_A2B2G2 +RE,R-HSA-165175,000482,TSC +RE,R-HSA-165180,000482,TSC +RE,R-HSA-1655720,000452,SREBF +RE,R-HSA-1655725,000452,SREBF +RE,R-HSA-1655726,000452,SREBF +RE,R-HSA-1655730,000452,SREBF +RE,R-HSA-1655732,000452,SREBF +RE,R-HSA-1655734,000452,SREBF +RE,R-HSA-165631,000502,ETC_complex_II +RE,R-HSA-165990,000381,PPP2R_A +RE,R-HSA-165997,000381,PPP2R_A +RE,R-HSA-167023,000432,SHC +RE,R-HSA-167204,000404,RAS +RE,R-HSA-167215,000448,SOS +RE,R-HSA-167409,000210,G_beta +RE,R-HSA-167410,000212,G_i +RE,R-HSA-167410,000213,G_i_alpha +RE,R-HSA-167413,000212,G_i +RE,R-HSA-167413,000213,G_i_alpha +RE,R-HSA-167438,000212,G_i +RE,R-HSA-167438,000213,G_i_alpha +RE,R-HSA-167442,000211,G_gamma +RE,R-HSA-1678828,000155,EIF4G +RE,R-HSA-168113,000250,IKK_complex +RE,R-HSA-169289,000161,ERK +RE,R-HSA-169291,000161,ERK +RE,R-HSA-170089,000131,Cyclin_A +RE,R-HSA-170108,000091,CDC25 +RE,R-HSA-170994,000400,RAL +RE,R-HSA-170998,000400,RAL +RE,R-HSA-171016,000326,p38 +RE,R-HSA-171172,000443,SMAD2_3 +RE,R-HSA-171182,000443,SMAD2_3 +RE,R-HSA-173584,000072,C1 +RE,R-HSA-173615,000072,C1 +RE,R-HSA-173617,000072,C1 +RE,R-HSA-173728,000278,MAC +RE,R-HSA-174074,000131,Cyclin_A +RE,R-HSA-174454,000411,RFC +RE,R-HSA-177105,000443,SMAD2_3 +RE,R-HSA-177656,000312,NFkappaB_1 +RE,R-HSA-177662,000312,NFkappaB_1 +RE,R-HSA-177663,000250,IKK_complex +RE,R-HSA-179508,000025,ALDO +RE,R-HSA-182582,000132,Cyclin_D +RE,R-HSA-182700,000132,Cyclin_D +RE,R-HSA-184196,000349,PDGF_BB +RE,R-HSA-184198,000349,PDGF_BB +RE,R-HSA-184203,000347,PDGF_AA +RE,R-HSA-184204,000349,PDGF_BB +RE,R-HSA-184206,000349,PDGF_BB +RE,R-HSA-186769,000343,PDGFR +RE,R-HSA-186769,000345,PDGFR_AB +RE,R-HSA-186770,000343,PDGFR +RE,R-HSA-186770,000345,PDGFR_AB +RE,R-HSA-186791,000343,PDGFR +RE,R-HSA-186791,000345,PDGFR_AB +RE,R-HSA-186792,000343,PDGFR +RE,R-HSA-186792,000345,PDGFR_AB +RE,R-HSA-186799,000346,PDGFR_BB +RE,R-HSA-186805,000346,PDGFR_BB +RE,R-HSA-186816,000344,PDGFR_AA +RE,R-HSA-186817,000344,PDGFR_AA +RE,R-HSA-186821,000343,PDGFR +RE,R-HSA-186821,000345,PDGFR_AB +RE,R-HSA-187493,000133,Cyclin_E +RE,R-HSA-189382,000240,HMOX +RE,R-HSA-189828,000326,p38 +RE,R-HSA-1911410,000055,ARRB +RE,R-HSA-1911440,000317,Notch +RE,R-HSA-1911472,000317,Notch +RE,R-HSA-1911474,000317,Notch +RE,R-HSA-1911547,000317,Notch +RE,R-HSA-1911550,000317,Notch +RE,R-HSA-195361,000495,VEGF +RE,R-HSA-195376,000495,VEGF +RE,R-HSA-196206,000379,PPP2 +RE,R-HSA-198358,000194,GSK3 +RE,R-HSA-198373,000194,GSK3 +RE,R-HSA-198701,000161,ERK +RE,R-HSA-198899,000090,CD8 +RE,R-HSA-200408,000042,AMPK_A2B2G2 +RE,R-HSA-200563,000005,ACC +RE,R-HSA-201465,000070,BMP_receptor_type_II +RE,R-HSA-201689,000145,DVL +RE,R-HSA-201711,000104,CK2 +RE,R-HSA-201725,000145,DVL +RE,R-HSA-201779,000384,PPP3C +RE,R-HSA-201798,000384,PPP3C +RE,R-HSA-201804,000070,BMP_receptor_type_II +RE,R-HSA-202052,000023,AKT +RE,R-HSA-202072,000023,AKT +RE,R-HSA-202074,000023,AKT +RE,R-HSA-202088,000023,AKT +RE,R-HSA-202513,000250,IKK_complex +RE,R-HSA-202562,000250,IKK_complex +RE,R-HSA-202877,000082,Caspase_3_7 +RE,R-HSA-2029095,000372,PLCG +RE,R-HSA-2029115,000494,VAV +RE,R-HSA-203947,000353,PDK +RE,R-HSA-206893,000011,Activin_A +RE,R-HSA-2089970,000109,COL1 +RE,R-HSA-212420,000317,Notch +RE,R-HSA-2127310,000111,COL5 +RE,R-HSA-2127389,000110,COL4 +RE,R-HSA-2127422,000111,COL5 +RE,R-HSA-2151208,000045,AMPK_beta +RE,R-HSA-2151212,000046,AMPK_gamma +RE,R-HSA-2151213,000044,AMPK_alpha +RE,R-HSA-215989,000273,Laminin_111 +RE,R-HSA-216001,000274,Laminin_332 +RE,R-HSA-2176482,000443,SMAD2_3 +RE,R-HSA-2187329,000443,SMAD2_3 +RE,R-HSA-2187387,000443,SMAD2_3 +RE,R-HSA-2213185,000142,DNM +RE,R-HSA-2220790,000274,Laminin_332 +RE,R-HSA-2316451,000046,AMPK_gamma +RE,R-HSA-2317310,000023,AKT +RE,R-HSA-2317317,000023,AKT +RE,R-HSA-2317329,000023,AKT +RE,R-HSA-2395330,000465,TGFB +RE,R-HSA-2396039,000109,COL1 +RE,R-HSA-2396161,000109,COL1 +RE,R-HSA-2396179,000109,COL1 +RE,R-HSA-2396183,000109,COL1 +RE,R-HSA-2396256,000109,COL1 +RE,R-HSA-2396260,000109,COL1 +RE,R-HSA-2396334,000109,COL1 +RE,R-HSA-2396451,000109,COL1 +RE,R-HSA-2396456,000109,COL1 +RE,R-HSA-2396478,000109,COL1 +RE,R-HSA-2399520,000109,COL1 +RE,R-HSA-2399659,000274,Laminin_332 +RE,R-HSA-2400006,000023,AKT +RE,R-HSA-2400013,000023,AKT +RE,R-HSA-2422450,000161,ERK +RE,R-HSA-2426131,000314,NFY +RE,R-HSA-2426276,000349,PDGF_BB +RE,R-HSA-2426371,000273,Laminin_111 +RE,R-HSA-2428941,000109,COL1 +RE,R-HSA-2445131,000264,IRS +RE,R-HSA-2445139,000264,IRS +RE,R-HSA-2457842,000323,p14_3_3 +RE,R-HSA-2470478,000010,Activin +RE,R-HSA-2470478,000012,Activin_AB +RE,R-HSA-2470491,000010,Activin +RE,R-HSA-2470491,000012,Activin_AB +RE,R-HSA-2470494,000010,Activin +RE,R-HSA-2470494,000012,Activin_AB +RE,R-HSA-2530496,000172,FNT +RE,R-HSA-2533911,000274,Laminin_332 +RE,R-HSA-264974,000164,EXOC +RE,R-HSA-2672035,000473,TN +RE,R-HSA-2681744,000473,TN +RE,R-HSA-2685653,000372,PLCG +RE,R-HSA-2685656,000409,RASGRP +RE,R-HSA-2990868,000101,Cholinesterase +RE,R-HSA-2993807,000392,Propionyl_CoA_carboxylase +RE,R-HSA-2993809,000392,Propionyl_CoA_carboxylase +RE,R-HSA-3132719,000163,ETS +RE,R-HSA-3132724,000163,ETS +RE,R-HSA-3200029,000163,ETS +RE,R-HSA-3238268,000497,Wnt +RE,R-HSA-3238374,000497,Wnt +RE,R-HSA-3247790,000497,Wnt +RE,R-HSA-3247824,000497,Wnt +RE,R-HSA-3247835,000497,Wnt +RE,R-HSA-3299546,000460,TCF_LEF +RE,R-HSA-3323122,000392,Propionyl_CoA_carboxylase +RE,R-HSA-3323155,000392,Propionyl_CoA_carboxylase +RE,R-HSA-3371429,000242,HSP90A +RE,R-HSA-349716,000306,NCOR +RE,R-HSA-3640819,000062,AXIN +RE,R-HSA-3640837,000101,Cholinesterase +RE,R-HSA-3640863,000062,AXIN +RE,R-HSA-3656389,000161,ERK +RE,R-HSA-374848,000215,G_q +RE,R-HSA-374848,000216,G_q_alpha +RE,R-HSA-376002,000003,ABL_family +RE,R-HSA-3772407,000145,DVL +RE,R-HSA-3772502,000062,AXIN +RE,R-HSA-378941,000219,hCG +RE,R-HSA-378947,000175,FSH +RE,R-HSA-378969,000276,LH +RE,R-HSA-380748,000349,PDGF_BB +RE,R-HSA-380751,000349,PDGF_BB +RE,R-HSA-380759,000348,PDGF_AB +RE,R-HSA-380759,000349,PDGF_BB +RE,R-HSA-380931,000031,AMPK +RE,R-HSA-380934,000031,AMPK +RE,R-HSA-380961,000031,AMPK +RE,R-HSA-381204,000314,NFY +RE,R-HSA-381844,000044,AMPK_alpha +RE,R-HSA-381845,000044,AMPK_alpha +RE,R-HSA-381851,000046,AMPK_gamma +RE,R-HSA-381854,000045,AMPK_beta +RE,R-HSA-381855,000482,TSC +RE,R-HSA-381926,000342,PDGF +RE,R-HSA-381930,000351,PDGF_DD +RE,R-HSA-381935,000349,PDGF_BB +RE,R-HSA-381936,000342,PDGF +RE,R-HSA-381938,000349,PDGF_BB +RE,R-HSA-381941,000350,PDGF_CC +RE,R-HSA-3858467,000145,DVL +RE,R-HSA-3858479,000145,DVL +RE,R-HSA-387074,000349,PDGF_BB +RE,R-HSA-388544,000149,EDN +RE,R-HSA-390455,000085,CCT_complex +RE,R-HSA-390474,000085,CCT_complex +RE,R-HSA-390532,000478,Troponin_C +RE,R-HSA-390541,000479,Troponin_I +RE,R-HSA-390546,000480,Troponin_T +RE,R-HSA-390583,000477,Troponin +RE,R-HSA-390585,000477,Troponin +RE,R-HSA-390587,000478,Troponin_C +RE,R-HSA-390643,000021,ADRB +RE,R-HSA-390664,000020,ADRA2 +RE,R-HSA-390670,000021,ADRB +RE,R-HSA-390700,000020,ADRA2 +RE,R-HSA-392712,000349,PDGF_BB +RE,R-HSA-399713,000191,GRIA +RE,R-HSA-399987,000215,G_q +RE,R-HSA-399987,000216,G_q_alpha +RE,R-HSA-399992,000215,G_q +RE,R-HSA-399992,000216,G_q_alpha +RE,R-HSA-400000,000215,G_q +RE,R-HSA-400000,000216,G_q_alpha +RE,R-HSA-400008,000215,G_q +RE,R-HSA-400008,000216,G_q_alpha +RE,R-HSA-400062,000211,G_gamma +RE,R-HSA-400093,000210,G_beta +RE,R-HSA-416323,000191,GRIA +RE,R-HSA-417004,000077,CAMK2_complex +RE,R-HSA-417004,000078,CAMK2_family +RE,R-HSA-418312,000430,SERCA +RE,R-HSA-418379,000391,PRKG +RE,R-HSA-418540,000340,PDE7 +RE,R-HSA-418541,000341,PDE8 +RE,R-HSA-418570,000207,G_12 +RE,R-HSA-418570,000208,G_12_alpha +RE,R-HSA-418572,000207,G_12 +RE,R-HSA-418572,000208,G_12_alpha +RE,R-HSA-419057,000419,ROCK +RE,R-HSA-419160,000414,RHO +RE,R-HSA-419161,000414,RHO +RE,R-HSA-419164,000414,RHO +RE,R-HSA-419294,000316,NOS +RE,R-HSA-419346,000427,S1PR +RE,R-HSA-419401,000427,S1PR +RE,R-HSA-419619,000242,HSP90A +RE,R-HSA-420516,000193,GRM +RE,R-HSA-420519,000193,GRM +RE,R-HSA-420974,000191,GRIA +RE,R-HSA-421001,000191,GRIA +RE,R-HSA-426070,000140,DGK +RE,R-HSA-427905,000430,SERCA +RE,R-HSA-428110,000374,PPAP2 +RE,R-HSA-428475,000330,PAK +RE,R-HSA-429349,000259,INS +RE,R-HSA-429352,000259,INS +RE,R-HSA-429384,000259,INS +RE,R-HSA-429407,000259,INS +RE,R-HSA-429472,000259,INS +RE,R-HSA-429842,000153,EIF4A +RE,R-HSA-430172,000494,VAV +RE,R-HSA-432792,000077,CAMK2_complex +RE,R-HSA-432792,000078,CAMK2_family +RE,R-HSA-434632,000494,VAV +RE,R-HSA-442272,000494,VAV +RE,R-HSA-442295,000494,VAV +RE,R-HSA-442734,000408,RASGRF +RE,R-HSA-444796,000077,CAMK2_complex +RE,R-HSA-444796,000078,CAMK2_family +RE,R-HSA-445134,000333,Patched +RE,R-HSA-445374,000077,CAMK2_complex +RE,R-HSA-445374,000078,CAMK2_family +RE,R-HSA-445744,000252,IL1 +RE,R-HSA-446847,000142,DNM +RE,R-HSA-446849,000329,P90RSK +RE,R-HSA-447102,000253,IL12 +RE,R-HSA-448866,000285,MEF2 +RE,R-HSA-448868,000285,MEF2 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+RE,R-HSA-5610566,000390,PRKAR +RE,R-HSA-5610568,000390,PRKAR +RE,R-HSA-5610577,000017,ADCY +RE,R-HSA-5610578,000017,ADCY +RE,R-HSA-5618088,000242,HSP90A +RE,R-HSA-5623453,000164,EXOC +RE,R-HSA-5656056,000171,FLRT +RE,R-HSA-5658216,000407,RasGAP +RE,R-HSA-5658219,000449,SPRED +RE,R-HSA-5672337,000482,TSC +RE,R-HSA-5672686,000286,MEK +RE,R-HSA-5672705,000286,MEK +RE,R-HSA-5672708,000399,RAF +RE,R-HSA-5672716,000286,MEK +RE,R-HSA-5672721,000286,MEK +RE,R-HSA-5672726,000399,RAF +RE,R-HSA-5674134,000399,RAF +RE,R-HSA-5674136,000399,RAF +RE,R-HSA-5674338,000161,ERK +RE,R-HSA-5674340,000161,ERK +RE,R-HSA-5674341,000161,ERK +RE,R-HSA-5674489,000286,MEK +RE,R-HSA-5675361,000161,ERK +RE,R-HSA-5675363,000161,ERK +RE,R-HSA-5682664,000056,ATG4 +RE,R-HSA-5693120,000064,BCKDC +RE,R-HSA-5696998,000131,Cyclin_A +RE,R-HSA-6783051,000131,Cyclin_A +RE,R-HSA-6792583,000064,BCKDC +RE,R-HSA-6793931,000276,LH +RE,R-HSA-6793934,000276,LH +RE,R-HSA-6798076,000327,p53_family +RE,R-HSA-6798078,000327,p53_family +RE,R-HSA-6802607,000404,RAS +RE,R-HSA-6802608,000404,RAS +RE,R-HSA-6805064,000125,CSNK2 +RE,R-HSA-6805066,000104,CK2 +RE,R-HSA-6805073,000125,CSNK2 +RE,R-HSA-6805467,000031,AMPK +RE,R-HSA-6813837,000133,Cyclin_E +RE,R-HSA-6814207,000210,G_beta +RE,R-HSA-6814413,000210,G_beta +RE,R-HSA-6814694,000138,Desmoglein +RE,R-HSA-68373,000133,Cyclin_E +RE,R-HSA-68436,000411,RFC +RE,R-HSA-68450,000141,DNA_polymerase_delta +RE,R-HSA-68462,000421,RPA +RE,R-HSA-69261,000091,CDC25 +RE,R-HSA-70019,000064,BCKDC +RE,R-HSA-70990,000502,ETC_complex_II +RE,R-HSA-71025,000392,Propionyl_CoA_carboxylase +RE,R-HSA-71026,000392,Propionyl_CoA_carboxylase +RE,R-HSA-72526,000152,EIF2B +RE,R-HSA-727820,000250,IKK_complex +RE,R-HSA-74674,000259,INS +RE,R-HSA-74688,000360,PI3K_p85 +RE,R-HSA-749499,000215,G_q +RE,R-HSA-749499,000216,G_q_alpha +RE,R-HSA-75202,000131,Cyclin_A +RE,R-HSA-77385,000259,INS +RE,R-HSA-8847714,000138,Desmoglein +RE,R-HSA-8848649,000079,CAPN +RE,R-HSA-8848668,000079,CAPN +RE,R-HSA-8849894,000170,FLOT +RE,R-HSA-8850524,000210,G_beta +RE,R-HSA-8852568,000278,MAC +RE,R-HSA-8855211,000061,Augmin +RE,R-HSA-8861873,000324,P2RX +RE,R-HSA-8864040,000343,PDGFR +RE,R-HSA-8864040,000345,PDGFR_AB +RE,R-HSA-8864046,000346,PDGFR_BB +RE,R-HSA-8864283,000463,TFAP2 +RE,R-HSA-8864286,000463,TFAP2 +RE,R-HSA-8865622,000454,STAT5 +RE,R-HSA-8866229,000022,ADRBK +RE,R-HSA-8868235,000142,DNM +RE,R-HSA-8868609,000142,DNM +RE,R-HSA-8870680,000169,Fibrinogen +RE,R-HSA-8936837,000232,HIF_beta +RE,R-HSA-8938866,000132,Cyclin_D +RE,R-HSA-8941923,000095,CDKN1 +RE,R-HSA-8942604,000095,CDKN1 +RE,R-HSA-8944354,000460,TCF_LEF +RE,R-HSA-8948131,000095,CDKN1 +RE,R-HSA-8950122,000253,IL12 +RE,R-HSA-8950228,000253,IL12 +RE,R-HSA-8950694,000253,IL12 +RE,R-HSA-8951427,000460,TCF_LEF +RE,R-HSA-909688,000246,IFNA +RE,R-HSA-936779,000057,ATP1A +RE,R-HSA-936820,000058,ATP1B +RE,R-HSA-976075,000148,E3_Ub_ligase +RE,R-HSA-996770,000184,GATA +SIGNOR,SIGNOR-PF1,000161,ERK +SIGNOR,SIGNOR-PF10,000145,DVL +SIGNOR,SIGNOR-PF11,000177,FZD +SIGNOR,SIGNOR-PF12,000311,NFkappaB +SIGNOR,SIGNOR-PF13,000330,PAK +SIGNOR,SIGNOR-PF14,000418,ROBO +SIGNOR,SIGNOR-PF15,000267,JNK +SIGNOR,SIGNOR-PF16,000326,p38 +SIGNOR,SIGNOR-PF17,000389,PRKAC +SIGNOR,SIGNOR-PF18,000384,PPP3C +SIGNOR,SIGNOR-PF2,000277,LPAR +SIGNOR,SIGNOR-PF20,000472,TLR +SIGNOR,SIGNOR-PF21,000458,TAOK +SIGNOR,SIGNOR-PF22,000462,TEAD +SIGNOR,SIGNOR-PF23,000168,FGFR +SIGNOR,SIGNOR-PF24,000023,AKT +SIGNOR,SIGNOR-PF25,000286,MEK +SIGNOR,SIGNOR-PF26,000329,P90RSK +SIGNOR,SIGNOR-PF27,000174,FOXO +SIGNOR,SIGNOR-PF29,000445,SMURF +SIGNOR,SIGNOR-PF3,000211,G_gamma +SIGNOR,SIGNOR-PF30,000317,Notch +SIGNOR,SIGNOR-PF31,000435,SLRP +SIGNOR,SIGNOR-PF32,000451,SRC +SIGNOR,SIGNOR-PF33,000187,GPCR +SIGNOR,SIGNOR-PF34,000362,PIM +SIGNOR,SIGNOR-PF35,000442,SMAD1_5_9 +SIGNOR,SIGNOR-PF4,000210,G_beta +SIGNOR,SIGNOR-PF5,000465,TGFB +SIGNOR,SIGNOR-PF6,000044,AMPK_alpha +SIGNOR,SIGNOR-PF7,000323,p14_3_3 +SIGNOR,SIGNOR-PF8,000167,FGF +SIGNOR,SIGNOR-PF9,000068,BMP_receptor diff --git a/famplex/resources/equivalences.tsv b/famplex/resources/equivalences.tsv deleted file mode 100644 index 173b408db..000000000 --- a/famplex/resources/equivalences.tsv +++ /dev/null @@ -1,1582 +0,0 @@ -BEL 14-3-3 Family 000323 p14_3_3 -BEL 9-1-1 Complex 000001 9_1_1 -BEL ACAD Family 000004 ACAD -BEL Acetyl CoA Carboxylase Complex 000005 ACC -BEL Acetyl-CoA Synthetase Family 000006 Acetyl_CoA_synthetase -BEL ACOX Family 000007 ACOX -BEL ACSL Family 000008 ACSL -BEL ACT Family 000009 Actin -BEL ACTN Family 000014 ACTN -BEL Adaptor Protein II Complex 000015 Adaptor_protein_II -BEL Adaptor Protein III Complex 000016 Adaptor_protein_III -BEL ADCY Family 000017 ADCY -BEL ADH Family 000018 ADH -BEL ADRA Family 000019 ADRA -BEL ADRA2 Family 000020 ADRA2 -BEL ADRB Family 000021 ADRB -BEL ADRBK Family 000022 ADRBK -BEL AKT Family 000023 AKT -BEL ALDH Family 000024 ALDH -BEL ALDO Family 000025 ALDO -BEL AMP Activated Protein Kinase Complex 000031 AMPK -BEL Annexin II Heterotetramer Complex 000047 Annexin_II_heterotetramer -BEL AP-1 Complex 000048 AP1 -BEL APOA Family 000051 APOA -BEL Arp2/3 Protein Complex 000054 Arp2_3_protein -BEL ARRB Family 000055 ARRB -BEL ATP2A Family 000430 SERCA -BEL ATP5G Family 000059 ATP5G -BEL AXIN Family 000062 AXIN -BEL BIRC Family 000066 BIRC -BEL BMP Family 000067 BMP -BEL BMP Receptor Type I Family 000069 BMP_receptor_type_I -BEL BMP Receptor Type II Family 000070 BMP_receptor_type_II -BEL Branched Chain Alpha Keto Acid Dehydrogenase Complex 000064 BCKDC -BEL C1 Complex 000072 C1 -BEL C1q Complex 000073 C1q -BEL Calcineurin Complex 000383 PPP3 -BEL CALM Family 000075 CALM -BEL CAMK Family 000076 CAMK -BEL CAMK2 Complex 000077 CAMK2_complex -BEL CAMK2 Family 000078 CAMK2_family -BEL CAPN Family 000079 CAPN -BEL Carboxylesterase Family 000080 Carboxylesterase -BEL CASP Family 000081 Caspase -BEL CAV Family 000083 CAV -BEL CBF3 Complex 000084 CBF3 -BEL CCNA Family 000131 Cyclin_A -BEL CCND Family 000132 Cyclin_D -BEL CCNE Family 000133 Cyclin_E -BEL CCT Complex 000085 CCT_complex -BEL CD16 Family 000086 CD16 -BEL CD3 Complex 000087 CD3 -BEL CD32 Family 000088 CD32 -BEL CD64 Family 000089 CD64 -BEL CDC25 Family 000091 CDC25 -BEL CDH Family 000074 Cadherin -BEL CEBP Family 000097 CEBP -BEL Chemokine Receptor Family 000100 Chemokine_receptor -BEL Cholinesterase Family 000101 Cholinesterase -BEL CHRM Family 000102 CHRM -BEL CHRN Complex 000103 CHRN -BEL CK II Complex 000104 CK2 -BEL Clathrin Complex 000105 Clathrin -BEL Cohesin Complex 000108 Cohesin -BEL COL1 Family 000109 COL1 -BEL COL4 Family 000110 COL4 -BEL COL5 Family 000111 COL5 -BEL COX4 Family 000114 COX4 -BEL COX6A Family 000115 COX6A -BEL COX6B Family 000116 COX6B -BEL COX7A Family 000117 COX7A -BEL COX7B Family 000118 COX7B -BEL COX8 Family 000119 COX8 -BEL CREB Family 000120 CREB -BEL CRISP Family 000121 CRISP -BEL CRSP Complex 000122 CRSP -BEL CSNK1 Family 000124 CSNK1 -BEL CSNK2 Family 000125 CSNK2 -BEL CTNNA Family 000126 CTNNA -BEL Cu-Zn SOD Family 000447 SOD -BEL CUL Family 000127 CUL -BEL CXCL ELR-Negative Family 000128 CXCL_ELR_negative -BEL CXCL ELR-Positive Family 000129 CXCL_ELR_positive -BEL Cyclophilin Family 000134 Cyclophilin -BEL Cytochrome C Oxidase Complex Muscle 000113 COX -BEL Cytochrome C Oxidase Complex Non Muscle 000113 COX -BEL Cytoplasmic Dynein Complex 000135 Cytoplasmic_dynein -BEL DDR Family 000136 DDR -BEL Desmoglein Family 000138 Desmoglein -BEL DGK Family 000140 DGK -BEL DNA Polymerase delta Complex 000141 DNA_polymerase_delta -BEL DNM Family 000142 DNM -BEL DRD Family 000143 DRD -BEL DVL Family 000145 DVL -BEL Dystrophin Associated Glycoprotein Complex 000139 DGC -BEL E2F Family 000147 E2F -BEL EDN Family 000149 EDN -BEL EGFR Ligand Family 000150 EGFR_ligand -BEL EGFR/ERBB Family 000160 ERBB -BEL EGR Family 000151 EGR -BEL EIF2B Complex 000152 EIF2B -BEL EIF4A Family 000153 EIF4A -BEL EIF4EBP Family 000154 EIF4EBP -BEL ELA Family 000156 ELA -BEL ENO Family 000157 ENO -BEL Ephrin Receptor Family 000158 Ephrin_receptor -BEL EPN Family 000159 EPN -BEL ESR Family 000162 ESR -BEL ETS Family 000163 ETS -BEL FGF Family 000167 FGF -BEL FGFR Family 000168 FGFR -BEL Fibrinogen Complex 000169 Fibrinogen -BEL FLOT Family 000170 FLOT -BEL FLRT Family 000171 FLRT -BEL Follicle Stimulating Hormone Complex 000175 FSH -BEL FOXO Family 000174 FOXO -BEL FZD Family 000177 FZD -BEL GABR Family 000179 GABR -BEL gamma Secretase Complex 000181 Gamma_secretase -BEL GAS6 Receptor Family 000183 GAS6_receptor -BEL GATA Family 000184 GATA -BEL GNA Gq Family 000215 G_q -BEL GNA Gs Family 000217 G_s -BEL GNAI Family 000212 G_i -BEL GNB Family 000210 G_beta -BEL GNG Family 000211 G_gamma -BEL GPIT Complex 000189 GPIT -BEL GPX Family 000190 GPX -BEL GRIA Family 000191 GRIA -BEL GRK Family 000192 GRK -BEL GRM Family 000193 GRM -BEL GSK3 Family 000194 GSK3 -BEL GST Family 000195 GST -BEL GTF2E Complex 000196 GTF2E -BEL GTF2F Complex 000197 GTF2F -BEL GUCY Family 000205 GUCY -BEL GYS Family 000206 GYS -BEL HDAC Class I Family 000221 HDAC_I -BEL HDAC Class II Family 000222 HDAC_II -BEL HDAC Family 000220 HDAC -BEL HDL Complex 000225 HDL -BEL Hedgehog Family 000226 Hedgehog -BEL Hemoglobin Complex 000227 Hemoglobin -BEL HES Family 000228 HES -BEL Histone Family 000233 Histone -BEL Histone H1 Family 000234 Histone_H1 -BEL Histone H2A Family 000235 Histone_H2A -BEL Histone H2B Family 000236 Histone_H2B -BEL Histone H3 Family 000237 Histone_H3 -BEL Histone H4 Family 000238 Histone_H4 -BEL HLA-DR Family 000239 HLA_DR -BEL HMOX Family 000240 HMOX -BEL HSP90 Family 000241 HSP90 -BEL HSPA Family 000244 HSPA -BEL HSPB Family 000245 HSPB -BEL Ib-V-IX Complex 000188 GPIb_IX_V -BEL IFNA Family 000246 IFNA -BEL IGFBP Family 000248 IGFBP -BEL IkappaB Kinase Complex 000250 IKK_complex -BEL IkappaB Kinase Family 000251 IKK_family -BEL IL1 Family 000252 IL1 -BEL INS Family 000259 INS -BEL INSR Family 000260 INSR -BEL Interferon Gamma Receptor Complex 000263 Interferon_gamma_receptor -BEL IRS Family 000264 IRS -BEL IRX Family 000265 IRX -BEL JAK Family 000266 JAK -BEL Kinetochore Complex 000270 Kinetochore -BEL KLK Family 000271 KLK -BEL Laminin 1 Complex 000273 Laminin_111 -BEL Laminin 5 Complex 000274 Laminin_332 -BEL LDH Family 000275 LDH -BEL Luteinizing Hormone Complex 000276 LH -BEL MAF Family 000279 MAF -BEL MAPK Erk1/2 Family 000161 ERK -BEL MAPK Erk1/3 Family 000161 ERK -BEL MAPK JNK Family 000267 JNK -BEL MAPK p38 Family 000326 p38 -BEL MEF2 Family 000285 MEF2 -BEL MEK1/2 Family 000286 MEK -BEL Membrane Attack Complex 000278 MAC -BEL MMP Family 000291 MMP -BEL MYH Family 000295 MYH -BEL MYL Alkali Family 000297 MYL_alkali -BEL MYL Family 000296 MYL -BEL MYL Regulatory Family 000298 MYL_regulatory -BEL MYL Slow Family 000299 MYL_slow -BEL MYST Family 000300 MYST -BEL Na/K Exchanging ATPase Complex 000303 Na_K_ATPase -BEL NADH Dehydrogenase Complex 000301 NADH_dehydrogenase -BEL NADPH Oxidase Complex 000302 NADPH_oxidase -BEL NCOR Family 000306 NCOR -BEL NDRG Family 000307 NDRG -BEL NFAT Family 000309 NFAT -BEL Nfkb Complex 000311 NFkappaB -BEL Nfy Complex 000314 NFY -BEL NKD Family 000315 NKD -BEL NOS Family 000316 NOS -BEL NOTCH Family 000317 Notch -BEL NRG1/2 Family 000319 NRG_1_2 -BEL NRG3/4 Family 000320 NRG_3_4 -BEL NTRK Family 000321 NTRK -BEL p160/SRC Family 000305 NCOA -BEL P2RX Family 000324 P2RX -BEL P2RY Family 000325 P2RY -BEL p85/p110 PI3Kinase Complex 000358 PI3K -BEL PAK Family 000330 PAK -BEL PARV Family 000332 PARV -BEL PBX Family 000334 PBX -BEL PDE Family 000335 PDE -BEL PDE1 Family 000336 PDE1 -BEL PDE3 Family 000337 PDE3 -BEL PDE4 Family 000338 PDE4 -BEL PDE6 Family 000339 PDE6 -BEL PDGF Family 000342 PDGF -BEL PDGFR Family 000343 PDGFR -BEL PDK Family 000353 PDK -BEL PFN Family 000355 PFN -BEL Phosphorylase B Kinase Complex 000356 PhK -BEL PIK3C Class IA Family 000359 PI3K_p110 -BEL PIK3R Class IA Family 000361 PIK3R_I -BEL PKI Family 000365 PKI -BEL PLA2 Family 000366 PLA2 -BEL PLA2G2 Family 000367 PLA2G2 -BEL PLC Family 000369 PLC -BEL PLCB Family 000370 PLCB -BEL PLCG Family 000372 PLCG -BEL PLD Family 000373 PLD -BEL PPAP2 Family 000374 PPAP2 -BEL PPAR Family 000375 PPAR -BEL PPP1C Family 000377 PPP1C -BEL PPP1R Family 000378 PPP1R -BEL PPP2C Family 000380 PPP2C -BEL PPP2R Subunit A Family 000381 PPP2R_A -BEL PPP2R Subunit B Family 000382 PPP2R_B -BEL PPP3 Family 000383 PPP3 -BEL PPP3C Family 000384 PPP3C -BEL PPP3R Family 000385 PPP3R -BEL PRC1 Maintenance Complex 000386 PRC1_complex -BEL PRC2 Initiation Complex 000387 PRC2_complex -BEL PRDX Family 000388 PRDX -BEL PRKA Family 000389 PRKAC -BEL PRKAA Family 000044 AMPK_alpha -BEL PRKAB Family 000045 AMPK_beta -BEL PRKAG Family 000046 AMPK_gamma -BEL PRKAR Family 000390 PRKAR -BEL PRKC Family 000364 PKC -BEL PRKG Family 000391 PRKG -BEL Propionyl CoA Carboxylase Complex 000392 Propionyl_CoA_carboxylase -BEL Proteasome Complex 000394 Proteasome -BEL Proton Transporting ATP Synthase Complex 000060 ATP_synthase -BEL PTGER Family 000395 PTGER -BEL Pyruvate Dehydrogenase Complex 000352 PDH -BEL RAB Family 000397 RAB -BEL RAC Family 000398 RAC -BEL RAF Family 000399 RAF -BEL RAR Family 000403 RAR -BEL RAS Family 000404 RAS -BEL Respiratory Chain Complex II 000502 ETC_complex_II -BEL Respiratory Chain Complex III 000503 ETC_complex_III -BEL RFC Complex 000411 RFC -BEL RFX Family 000412 RFX -BEL RHO Family 000414 RHO -BEL RNApo I Complex 000416 RNApo_I -BEL RNApo II Complex 000417 RNApo_II -BEL ROCK Family 000419 ROCK -BEL ROR Family 000420 ROR -BEL RPS6KA Family 000329 P90RSK -BEL RPS6KB Family 000328 P70S6K -BEL RXR Family 000424 RXR -BEL S100A Family 000426 S100A -BEL S1PR Family 000427 S1PR -BEL SAA Family 000428 SAA -BEL SCD Family 000429 SCD -BEL SERPINB Family 000431 SERPINB -BEL SLC2A Family 000434 SLC2A -BEL SMAD Family 000441 SMAD -BEL SMC1 Family 000444 SMC1 -BEL SNAI Family 000446 SNAI -BEL SOS Family 000448 SOS -BEL SRC Family 000451 SRC -BEL SREBF Family 000452 SREBF -BEL STAT Family 000453 STAT -BEL STAT5 Family 000454 STAT5 -BEL Sulfonylurea Receptor Family 000456 Sulfonylurea_receptor -BEL SWI/SNF Complex 000457 SWI_SNF -BEL TAP Family 000459 TAP -BEL TCF/LEF Family 000460 TCF_LEF -BEL TFAP2 Family 000463 TFAP2 -BEL TFDP Family 000464 TFDP -BEL TGFB Family 000465 TGFB -BEL THBS Family 000467 THBS -BEL THR Family 000468 THR -BEL Thrombin Antithrombin Complex 000469 Thrombin_antithrombin -BEL TIF IB Complex 000471 TIF_IB -BEL TN Family 000473 TN -BEL TNFRSF Family 000475 TNFRSF -BEL TOP2 Family 000476 TOP2 -BEL TORC2 Complex 000294 mTORC2 -BEL Tryptase Family 000481 Tryptase -BEL TUBA Family 000483 TUBA -BEL TUBB Family 000484 TUBB -BEL TXN Family 000487 TXN -BEL TXNRD Family 000488 TXNRD -BEL UBE2 Family 000489 UBE2 -BEL VAV Family 000494 VAV -BEL VEGF Family 000495 VEGF -BEL VEGFR Family 000496 VEGFR -BEL WNT Family 000497 Wnt -COMPLEXPORTAL CPX-560 000503 ETC_complex_III -COMPLEXPORTAL CPX-561 000502 ETC_complex_II -COMPLEXPORTAL CPX-577 000501 ETC_complex_I -ECCODE 1.1.1.1 000018 ADH -ECCODE 1.10.2.2 000503 ETC_complex_III -ECCODE 1.11.1.15 000388 PRDX -ECCODE 1.11.1.9 000190 GPX -ECCODE 1.14.19.1 000429 SCD -ECCODE 1.14.99.3 000240 HMOX -ECCODE 1.2.1.3 000024 ALDH -ECCODE 1.2.4.1 000353 PDK -ECCODE 1.3.5.1 000502 ETC_complex_II -ECCODE 1.3.8.7 000004 ACAD -ECCODE 1.6.5.3 000501 ETC_complex_I -ECCODE 1.6.5.3 000301 NADH_dehydrogenase -ECCODE 1.9.3.1 000113 COX -ECCODE 1.9.3.1 000504 ETC_complex_IV -ECCODE 2.3.2.23 000489 UBE2 -ECCODE 2.5.1.58 000172 FNT -ECCODE 2.7.1.107 000140 DGK -ECCODE 2.7.11.11 000363 PKA -ECCODE 2.7.11.12 000391 PRKG -ECCODE 2.7.11.13 000364 PKC -ECCODE 2.7.11.16 000192 GRK -ECCODE 2.7.11.17 000076 CAMK -ECCODE 2.7.11.19 000356 PhK -ECCODE 2.7.11.22 000092 CDK -ECCODE 2.7.11.24 000283 MAPK -ECCODE 2.7.11.25 000282 MAP3K -ECCODE 2.7.11.31 000031 AMPK -ECCODE 2.7.12.2 000283 MAPK -ECCODE 3.1.1.1 000080 Carboxylesterase -ECCODE 3.1.1.4 000366 PLA2 -ECCODE 3.1.4.- 000335 PDE -ECCODE 3.1.4.4 000373 PLD -ECCODE 3.4.21.35 000271 KLK -ECCODE 3.4.21.59 000481 Tryptase -ECCODE 3.4.25.1 000394 Proteasome -ECCODE 3.5.1.98 000220 HDAC -ECCODE 3.6.3.14 000505 ETC_complex_V -ECCODE 3.6.3.9 000303 Na_K_ATPase -ECCODE 3.6.5.- 000204 GTPase -ECCODE 4.1.2.13 000025 ALDO -ECCODE 4.6.1.2 000205 GUCY -ECCODE 6.4.1.2 000005 ACC -ECCODE 6.4.1.3 000392 Propionyl_CoA_carboxylase -GFAM 1199 000269 Kainate_family -GFAM 1582 000308 Neurexins -GO GO:0000145 000164 EXOC -GO GO:0000502 000394 Proteasome -GO GO:0000776 000270 Kinetochore -GO GO:0000930 000485 TUBG -GO GO:0004117 000336 PDE1 -GO GO:0004198 000079 CAPN -GO GO:0004199 000081 Caspase -GO GO:0004886 000424 RXR -GO GO:0004890 000179 GABR -GO GO:0004931 000324 P2RX -GO GO:0004936 000019 ADRA -GO GO:0004937 000019 ADRA -GO GO:0004938 000020 ADRA2 -GO GO:0004952 000143 DRD -GO GO:0005007 000168 FGFR -GO GO:0005035 000137 Death_receptor -GO GO:0005094 000415 RhoGDI -GO GO:0005096 000182 GAP -GO GO:0005154 000150 EGFR_ligand -GO GO:0005161 000342 PDGF -GO GO:0005162 000167 FGF -GO GO:0005172 000496 VEGFR -GO GO:0005355 000434 SLC2A -GO GO:0005577 000169 Fibrinogen -GO GO:0005579 000278 MAC -GO GO:0005584 000109 COL1 -GO GO:0005587 000110 COL4 -GO GO:0005588 000111 COL5 -GO GO:0005610 000274 Laminin_332 -GO GO:0005663 000411 RFC -GO GO:0005665 000417 RNApo_II -GO GO:0005673 000196 GTF2E -GO GO:0005674 000197 GTF2F -GO GO:0005680 000050 APC_C -GO GO:0005736 000416 RNApo_I -GO GO:0005747 000501 ETC_complex_I -GO GO:0005749 000502 ETC_complex_II -GO GO:0005750 000503 ETC_complex_III -GO GO:0005751 000504 ETC_complex_IV -GO GO:0005753 000505 ETC_complex_V -GO GO:0005761 000288 Mitochondrial_Ribosome -GO GO:0005762 000290 MRPL -GO GO:0005763 000289 MRPS -GO GO:0005832 000085 CCT_complex -GO GO:0005861 000477 Troponin -GO GO:0005868 000135 Cytoplasmic_dynein -GO GO:0005884 000009 Actin -GO GO:0005956 000104 CK2 -GO GO:0008190 000154 EIF4EBP -GO GO:0008278 000108 Cohesin -GO GO:0008279 000108 Cohesin -GO GO:0008281 000456 Sulfonylurea_receptor -GO GO:0008433 000186 GEF -GO GO:0008599 000376 PPP1 -GO GO:0016010 000139 DGC -GO GO:0016190 000105 Clathrin -GO GO:0016904 000103 CHRN -GO GO:0016914 000175 FSH -GO GO:0019787 000489 UBE2 -GO GO:0030122 000015 Adaptor_protein_II -GO GO:0031518 000084 CBF3 -GO GO:0031931 000293 mTORC1 -GO GO:0031941 000178 F_actin -GO GO:0032281 000191 GRIA -GO GO:0034364 000225 HDL -GO GO:0034666 000261 Integrins -GO GO:0034683 000261 Integrins -GO GO:0034687 000261 Integrins -GO GO:0035098 000387 PRC2_complex -GO GO:0035102 000386 PRC1_complex -GO GO:0038036 000427 S1PR -GO GO:0042555 000284 MCM -GO GO:0042825 000459 TAP -GO GO:0043509 000011 Activin_A -GO GO:0043511 000256 Inhibin -GO GO:0043625 000141 DNA_polymerase_delta -GO GO:0045275 000503 ETC_complex_III -GO GO:0048180 000010 Activin -GO GO:0070652 000061 Augmin -GO GO:0070765 000181 Gamma_secretase -GO GO:1990779 000188 GPIb_IX_V -HGNC_GROUP 1149 000499 ETC_complex_I_core -HGNC_GROUP 1150 000500 ETC_complex_I_supernumerary -HGNC_GROUP 581 000061 Augmin -HGNC_GROUP 640 000501 ETC_complex_I -HGNC_GROUP 641 000502 ETC_complex_II -HGNC_GROUP 642 000503 ETC_complex_III -HGNC_GROUP 643 000504 ETC_complex_IV -HGNC_GROUP 644 000505 ETC_complex_V -IP IPR000074 000052 Apolipoprotein -IP IPR000096 000428 SAA -IP IPR000162 000193 GRM -IP IPR000164 000237 Histone_H3 -IP IPR000239 000192 GRK -IP IPR000308 000323 p14_3_3 -IP IPR000320 000226 Hedgehog -IP IPR000381 000013 Activin_B -IP IPR000388 000456 Sulfonylurea_receptor -IP IPR000406 000415 RhoGDI -IP IPR000451 000311 NFkappaB -IP IPR000454 000059 ATP5G -IP IPR000469 000207 G_12 -IP IPR000469 000208 G_12_alpha -IP IPR000491 000011 Activin_A -IP IPR000654 000215 G_q -IP IPR000654 000216 G_q_alpha -IP IPR000741 000025 ALDO -IP IPR000751 000091 CDC25 -IP IPR000756 000140 DGK -IP IPR000889 000190 GPX -IP IPR000929 000143 DRD -IP IPR000941 000157 ENO -IP IPR000995 000102 CHRM -IP IPR000997 000101 Cholinesterase -IP IPR001090 000158 Ephrin_receptor -IP IPR001132 000441 SMAD -IP IPR001154 000476 TOP2 -IP IPR001208 000284 MCM -IP IPR001217 000453 STAT -IP IPR001241 000476 TOP2 -IP IPR001349 000115 COX6A -IP IPR001370 000066 BIRC -IP IPR001408 000212 G_i -IP IPR001408 000213 G_i_alpha -IP IPR001426 000158 Ephrin_receptor -IP IPR001429 000324 P2RX -IP IPR001442 000110 COL4 -IP IPR001522 000429 SCD -IP IPR001612 000083 CAV -IP IPR001657 000226 Hedgehog -IP IPR001767 000226 Hedgehog -IP IPR001770 000211 G_gamma -IP IPR001928 000149 EDN -IP IPR001951 000238 Histone_H4 -IP IPR002051 000240 HMOX -IP IPR002112 000268 JUN_family -IP IPR002117 000327 p53_family -IP IPR002138 000081 Caspase -IP IPR002194 000085 CCT_complex -IP IPR002205 000476 TOP2 -IP IPR002209 000167 FGF -IP IPR002374 000391 PRKG -IP IPR002453 000484 TUBB -IP IPR002454 000485 TUBG -IP IPR002655 000007 ACOX -IP IPR002717 000300 MYST -IP IPR003000 000223 HDAC_III -IP IPR003074 000375 PPAR -IP IPR003084 000220 HDAC -IP IPR003084 000221 HDAC_I -IP IPR003113 000359 PI3K_p110 -IP IPR003175 000095 CDKN1 -IP IPR003205 000119 COX8 -IP IPR003367 000467 THBS -IP IPR003502 000252 IL1 -IP IPR003586 000226 Hedgehog -IP IPR003587 000226 Hedgehog -IP IPR004000 000009 Actin -IP IPR004030 000316 NOS -IP IPR004061 000427 S1PR -IP IPR004142 000307 NDRG -IP IPR004171 000365 PKI -IP IPR004203 000114 COX4 -IP IPR004241 000280 MAP1LC3 -IP IPR004766 000333 Patched -IP IPR004826 000279 MAF -IP IPR004979 000463 TFAP2 -IP IPR005455 000355 PFN -IP IPR005542 000334 PBX -IP IPR005643 000268 JUN_family -IP IPR005782 000430 SERCA -IP IPR005817 000497 Wnt -IP IPR006019 000432 SHC -IP IPR006338 000488 TXNRD -IP IPR006828 000045 AMPK_beta -IP IPR008297 000317 Notch -IP IPR008349 000161 ERK -IP IPR008351 000267 JNK -IP IPR008352 000326 p38 -IP IPR008366 000309 NFAT -IP IPR008433 000118 COX7B -IP IPR008606 000154 EIF4EBP -IP IPR008631 000206 GYS -IP IPR008859 000467 THBS -IP IPR009045 000226 Hedgehog -IP IPR009123 000138 Desmoglein -IP IPR010011 000305 NCOA -IP IPR010660 000317 Notch -IP IPR010991 000327 p53_family -IP IPR011039 000197 GTF2F -IP IPR011615 000327 p53_family -IP IPR011656 000317 Notch -IP IPR012144 000316 NOS -IP IPR012198 000390 PRKAR -IP IPR012233 000364 PKC -IP IPR012290 000169 Fibrinogen -IP IPR012345 000453 STAT -IP IPR012542 000476 TOP2 -IP IPR013019 000441 SMAD -IP IPR013288 000114 COX4 -IP IPR013506 000476 TOP2 -IP IPR013537 000005 ACC -IP IPR013543 000077 CAMK2_complex -IP IPR013543 000078 CAMK2_family -IP IPR013558 000460 TCF_LEF -IP IPR013706 000336 PDE1 -IP IPR013757 000476 TOP2 -IP IPR013758 000476 TOP2 -IP IPR013759 000476 TOP2 -IP IPR013760 000476 TOP2 -IP IPR013790 000441 SMAD -IP IPR013799 000453 STAT -IP IPR013800 000453 STAT -IP IPR013801 000453 STAT -IP IPR013854 000463 TFAP2 -IP IPR013871 000121 CRISP -IP IPR014788 000101 Cholinesterase -IP IPR014920 000305 NCOA -IP IPR014935 000305 NCOA -IP IPR014936 000062 AXIN -IP IPR015008 000419 ROCK -IP IPR015015 000003 ABL_family -IP IPR015451 000132 Cyclin_D -IP IPR015583 000349 PDGF_BB -IP IPR015588 000247 IFNB -IP IPR015615 000465 TGFB -IP IPR015633 000147 E2F -IP IPR015679 000373 PLD -IP IPR015876 000429 SCD -IP IPR015988 000453 STAT -IP IPR016053 000240 HMOX -IP IPR016072 000084 CBF3 -IP IPR016084 000240 HMOX -IP IPR016239 000329 P90RSK -IP IPR016245 000160 ERBB -IP IPR016246 000260 INSR -IP IPR016247 000420 ROR -IP IPR016248 000168 FGFR -IP IPR016251 000266 JAK -IP IPR016257 000158 Ephrin_receptor -IP IPR016279 000372 PLCG -IP IPR016280 000370 PLCB -IP IPR016311 000163 ETS -IP IPR016319 000465 TGFB -IP IPR016346 000210 G_beta -IP IPR016897 000084 CBF3 -IP IPR017104 000049 AP2A -IP IPR017348 000362 PIM -IP IPR017426 000305 NCOA -IP IPR017897 000467 THBS -IP IPR017904 000107 Cofilin -IP IPR018161 000497 Wnt -IP IPR018207 000240 HMOX -IP IPR018361 000083 CAV -IP IPR018507 000115 COX6A -IP IPR018522 000476 TOP2 -IP IPR019764 000149 EDN -IP IPR020475 000149 EDN -IP IPR020537 000059 ATP5G -IP IPR020684 000419 ROCK -IP IPR020777 000321 NTRK -IP IPR020810 000157 ENO -IP IPR020811 000157 ENO -IP IPR022684 000079 CAPN -IP IPR023272 000118 COX7B -IP IPR023337 000449 SPRED -IP IPR023409 000323 p14_3_3 -IP IPR023410 000323 p14_3_3 -IP IPR024940 000460 TCF_LEF -IP IPR024946 000476 TOP2 -IP IPR025561 000272 KSR -IP IPR026590 000223 HDAC_III -IP IPR027288 000346 PDGFR_BB -IP IPR027290 000344 PDGFR_AA -IP IPR027309 000324 P2RX -IP IPR027705 000170 FLOT -IP IPR027707 000480 Troponin_T -IP IPR027936 000158 Ephrin_receptor -IP IPR028412 000400 RAL -IP IPR028433 000332 PARV -IP IPR028858 000133 Cyclin_E -IP IPR028974 000467 THBS -IP IPR028992 000226 Hedgehog -IP IPR029760 000190 GPX -IP IPR029768 000025 ALDO -IP IPR030492 000311 NFkappaB -IP IPR031327 000284 MCM -IP IPR031635 000321 NTRK -IP IPR031660 000476 TOP2 -IP IPR031675 000377 PPP1C -IP IPR031905 000170 FLOT -IP IPR032067 000174 FOXO -IP IPR032101 000062 AXIN -IP IPR032270 000044 AMPK_alpha -IP IPR032640 000045 AMPK_beta -IP IPR033139 000081 Caspase -IP IPR033614 000410 RASSF -IP IPR033896 000285 MEF2 -IP IPR033923 000330 PAK -IP IPR033926 000311 NFkappaB -IP IPR034117 000121 CRISP -IP IPR034157 000476 TOP2 -IP IPR035014 000391 PRKG -IP IPR035023 000372 PLCG -IP IPR035024 000372 PLCG -MEDSCAN urn:agi-aopfc:0000094 000120 CREB -MEDSCAN urn:agi-aopfc:0000099 000147 E2F -MEDSCAN urn:agi-aopfc:0000105 000184 GATA -MEDSCAN urn:agi-aopfc:0000142 000279 MAF -MEDSCAN urn:agi-aopfc:0000143 000285 MEF2 -MEDSCAN urn:agi-aopfc:0000150 000310 NFE -MEDSCAN urn:agi-aopfc:0000156 000311 NFkappaB -MEDSCAN urn:agi-aopfc:0000157 000412 RFX -MEDSCAN urn:agi-aopfc:0000159 000441 SMAD -MEDSCAN urn:agi-aopfc:0000163 000453 STAT -MEDSCAN urn:agi-aopfc:0000197 000177 FZD -MEDSCAN urn:agi-aopfc:0000252 000136 DDR -MEDSCAN urn:agi-aopfc:0000264 000260 INSR -MEDSCAN urn:agi-aopfc:0000278 000321 NTRK -MEDSCAN urn:agi-aopfc:0000279 000317 Notch -MEDSCAN urn:agi-aopfc:0000281 000333 Patched -MEDSCAN urn:agi-aopfc:0000286 000420 ROR -MEDSCAN urn:agi-aopfc:0000294 000466 TGFBR -MEDSCAN urn:agi-aopfc:0000295 000475 TNFRSF -MEDSCAN urn:agi-aopfc:0000296 000472 TLR -MEDSCAN urn:agi-aopfc:0000311 000187 GPCR -MEDSCAN urn:agi-aopfc:0000391 000099 Chemokine -MEDSCAN urn:agi-aopfc:0000423 000465 TGFB -MEDSCAN urn:agi-aopfc:0000426 000497 Wnt -MEDSCAN urn:agi-aopfc:0000434 000194 GSK3 -MEDSCAN urn:agi-aopfc:0000439 000023 AKT -MEDSCAN urn:agi-aopfc:0000447 000358 PI3K -MEDSCAN urn:agi-aopfc:0000452 000075 CALM -MEDSCAN urn:agi-aopfc:0000455 000366 PLA2 -MEDSCAN urn:agi-aopfc:0000458 000161 ERK -MEDSCAN urn:agi-aopfc:0000462 000286 MEK -MEDSCAN urn:agi-aopfc:0000464 000266 JAK -MEDSCAN urn:agi-aopfc:0000465 000404 RAS -MEDSCAN urn:agi-aopfc:0000468 000330 PAK -MEDSCAN urn:agi-aopfc:0000473 000267 JNK -MEDSCAN urn:agi-aopfc:0000477 000326 p38 -MEDSCAN urn:agi-aopfc:0000479 000302 NADPH_oxidase -MEDSCAN urn:agi-aopfc:0000494 000316 NOS -MEDSCAN urn:agi-aopfc:0000499 000414 RHO -MEDSCAN urn:agi-aopfc:0000504 000494 VAV -MEDSCAN urn:agi-aopfc:0000509 000451 SRC -MEDSCAN urn:agi-aopfc:0000551 000091 CDC25 -MEDSCAN urn:agi-aopfc:0000567 000003 ABL_family -MEDSCAN urn:agi-aopfc:0000571 000050 APC_C -MEDSCAN urn:agi-aopfc:0000585 000264 IRS -MEDSCAN urn:agi-aopfc:0000586 000248 IGFBP -MEDSCAN urn:agi-aopfc:0000587 000226 Hedgehog -MEDSCAN urn:agi-aopfc:0000615 000252 IL1 -MEDSCAN urn:agi-aopfc:0000704 000339 PDE6 -MEDSCAN urn:agi-complex:CaM%20kinase%20II 000077 CAMK2_complex -MEDSCAN urn:agi-complex:CD3%20complex 000087 CD3 -MEDSCAN urn:agi-complex:CD8 000090 CD8 -MEDSCAN urn:agi-complex:HIF-1 000230 HIF1 -MEDSCAN urn:agi-complex:IFNGR 000263 Interferon_gamma_receptor -MEDSCAN urn:agi-complex:IKK%20complex 000250 IKK_complex -MEDSCAN urn:agi-complex:IL12 000253 IL12 -MEDSCAN urn:agi-complex:inhibin%20A 000257 Inhibin_A -MEDSCAN urn:agi-complex:Luteinizing%20hormone 000276 LH -MEDSCAN urn:agi-complex:MAC-1%20(integrin) 000261 Integrins -MEDSCAN urn:agi-complex:NF-E2 000310 NFE -MEDSCAN urn:agi-complex:platelet%20derived%20growth%20factor%20AA 000347 PDGF_AA -MEDSCAN urn:agi-complex:platelet%20derived%20growth%20factor%20AB 000348 PDGF_AB -MEDSCAN urn:agi-complex:platelet%20derived%20growth%20factor%20BB 000349 PDGF_BB -MEDSCAN urn:agi-complex:prophash-047b61fab6d7e7445346cc84dafcb267 000177 FZD -MEDSCAN urn:agi-complex:prophash-0d528c29d63997f87f62e4fbd9f0b168 000294 mTORC2 -MEDSCAN urn:agi-complex:prophash-0f8242e28423189d7ef714808fdcc121 000233 Histone -MEDSCAN urn:agi-complex:prophash-285b9ff3749679e4d6266406a20973aa 000358 PI3K -MEDSCAN urn:agi-complex:prophash-2b612daa76feb2db86ff39e70449df6b 000387 PRC2_complex -MEDSCAN urn:agi-complex:prophash-2de597c3f4a807f3caeaf02e5f93ce15 000453 STAT -MEDSCAN urn:agi-complex:prophash-40bc2e4348830d6f7bdacd573fd7c388 000147 E2F -MEDSCAN urn:agi-complex:prophash-44f61960049704dc2afb23ff7c324b85 000230 HIF1 -MEDSCAN urn:agi-complex:prophash-4dda466320b1a32b046d823accadbaee 000092 CDK -MEDSCAN urn:agi-complex:prophash-50bd08479c3770278693a51fe379babd 000490 Ubiquitin -MEDSCAN urn:agi-complex:prophash-72ef5fc0ab431a39e0e2915bf55b6e28 000441 SMAD -MEDSCAN urn:agi-complex:prophash-7629c2cdfdf4908b72f13917a7c1551e 000411 RFC -MEDSCAN urn:agi-complex:prophash-763d31b31e177311583df0ac1ea015da 000187 GPCR -MEDSCAN urn:agi-complex:prophash-7e8823afb9ca7870b95633dcb782500b 000220 HDAC -MEDSCAN urn:agi-complex:prophash-8a9e47ee0ee03d8d8b6e029e2fba6896 000074 Cadherin -MEDSCAN urn:agi-complex:prophash-8cfce9bfac3857e6f068d517deadfeaa 000311 NFkappaB -MEDSCAN urn:agi-complex:prophash-8d885376e30916afd0b47ccf1b044e75 000268 JUN_family -MEDSCAN urn:agi-complex:prophash-90a087d4e73b3992c65edfd9f71c6802 000486 Tubulin -MEDSCAN urn:agi-complex:prophash-9e456bf1de2c5eb1107156c96a1450e6 000466 TGFBR -MEDSCAN urn:agi-complex:prophash-aba0c4130764ae7a26054736114e65cd 000386 PRC1_complex -MEDSCAN urn:agi-complex:prophash-bd459ca2937257c9e3f2b75abf22f422 000424 RXR -MEDSCAN urn:agi-complex:prophash-c3bac0781a4430da4cf6721b8f7537d9 000127 CUL -MEDSCAN urn:agi-complex:prophash-cd6413d79122d5489ee4b4e339245b61 000085 CCT_complex -MEDSCAN urn:agi-complex:prophash-d39afef40daf23ad8376b53904c7092c 000376 PPP1 -MEDSCAN urn:agi-complex:prophash-d9fbae788d60df23b6be4a3ead2cbab4 000417 RNApo_II -MEDSCAN urn:agi-complex:prophash-dd63d0a558770b12c9149b4955828f35 000050 APC_C -MEDSCAN urn:agi-complex:prophash-e4ec238e69c3d3292966ac97dbc11086 000477 Troponin -MEDSCAN urn:agi-complex:prophash-e6be10f6a8e79aed1daa4ec2ac191db1 000284 MCM -MEDSCAN urn:agi-complex:prophash-e9fbfd73e486bda4d99b348f72bb4196 000204 GTPase -MEDSCAN urn:agi-complex:prophash-f2e03d3bf1f747adab17ce77b9b5e5b3 000379 PPP2 -MEDSCAN urn:agi-complex:prophash-f472fef3f59301aee0b776702a30f03e 000293 mTORC1 -MEDSCAN urn:agi-complex:prophash-f7a9dc05e48afd7a93466cfbd5504861 000457 SWI_SNF -MEDSCAN urn:agi-complex:prophash-f7e292d6e30998b81cf5f772ab430f11 000075 CALM -MEDSCAN urn:agi-complex:protein%20phosphatase%203 000383 PPP3 -MEDSCAN urn:agi-complex:protein%20phosphatase%20type%201%20complex 000376 PPP1 -MEDSCAN urn:agi-complex:protein%20phosphatase%20type%202A%20complex 000379 PPP2 -MEDSCAN urn:agi-complex:SMAD2%2f3 000443 SMAD2_3 -MEDSCAN urn:agi-protfc:14-3-3 000323 p14_3_3 -MEDSCAN urn:agi-protfc:actins 000009 Actin -MEDSCAN urn:agi-protfc:AMPK 000031 AMPK -MEDSCAN urn:agi-protfc:apolipoprotein 000052 Apolipoprotein -MEDSCAN urn:agi-protfc:bone%20morphogenetic%20protein%20I%20receptor 000069 BMP_receptor_type_I -MEDSCAN urn:agi-protfc:cadherin 000074 Cadherin -MEDSCAN urn:agi-protfc:casein%20kinase%20I 000124 CSNK1 -MEDSCAN urn:agi-protfc:caveolin 000083 CAV -MEDSCAN urn:agi-protfc:checkpoint%20kinase 000098 CHEK -MEDSCAN urn:agi-protfc:chromatin%20remodeling%20complex 000457 SWI_SNF -MEDSCAN urn:agi-protfc:class%20c%20orphan%20receptor 000187 GPCR -MEDSCAN urn:agi-protfc:cullin 000127 CUL -MEDSCAN urn:agi-protfc:cyclin 000130 Cyclin -MEDSCAN urn:agi-protfc:cyclophilins 000134 Cyclophilin -MEDSCAN urn:agi-protfc:cytosolic%20phospholipase%20a2 000366 PLA2 -MEDSCAN urn:agi-protfc:desmoglein 000138 Desmoglein -MEDSCAN urn:agi-protfc:endothelin 000149 EDN -MEDSCAN urn:agi-protfc:F-actin-binding%20protein 000178 F_actin -MEDSCAN urn:agi-protfc:flotillin 000170 FLOT -MEDSCAN urn:agi-protfc:hemoglobin 000227 Hemoglobin -MEDSCAN urn:agi-protfc:histone%20H1 000234 Histone_H1 -MEDSCAN urn:agi-protfc:histone%20H2A 000235 Histone_H2A -MEDSCAN urn:agi-protfc:histone%20H2B 000236 Histone_H2B -MEDSCAN urn:agi-protfc:histone%20H3 000237 Histone_H3 -MEDSCAN urn:agi-protfc:histone%20H4 000238 Histone_H4 -MEDSCAN urn:agi-protfc:histone 000233 Histone -MEDSCAN urn:agi-protfc:interferon 000262 Interferon -MEDSCAN urn:agi-protfc:kallikrein 000271 KLK -MEDSCAN urn:agi-protfc:mglur 000193 GRM -MEDSCAN urn:agi-protfc:myosin%20heavy%20chain 000295 MYH -MEDSCAN urn:agi-protfc:myosin%20light%20chain 000296 MYL -MEDSCAN urn:agi-protfc:neuregulin%20family 000318 NRG -MEDSCAN urn:agi-protfc:p2y%20receptor 000325 P2RY -MEDSCAN urn:agi-protfc:p70rsk 000328 P70S6K -MEDSCAN urn:agi-protfc:p90rsk 000329 P90RSK -MEDSCAN urn:agi-protfc:PDE4%20subfamily 000338 PDE4 -MEDSCAN urn:agi-protfc:phosphodiesterase%20III 000337 PDE3 -MEDSCAN urn:agi-protfc:ppar 000375 PPAR -MEDSCAN urn:agi-protfc:profilin 000355 PFN -MEDSCAN urn:agi-protfc:rab 000397 RAB -MEDSCAN urn:agi-protfc:sarcoplasmic%20reticulum%20calcium%20transporting%20adenosine%20triphosphatase 000430 SERCA -MEDSCAN urn:agi-protfc:shc%20protein 000432 SHC -MEDSCAN urn:agi-protfc:STAT5%20protein 000454 STAT5 -MEDSCAN urn:agi-protfc:sterol%20regulatory%20element%20binding%20protein 000452 SREBF -MEDSCAN urn:agi-protfc:SWI%2fSNF%20family 000457 SWI_SNF -MEDSCAN urn:agi-protfc:thioredoxin 000487 TXN -MEDSCAN urn:agi-protfc:thrombospondins 000467 THBS -MEDSCAN urn:agi-protfc:tubulin 000486 Tubulin -MEDSCAN urn:agi-protfc:ubiquitin 000490 Ubiquitin -MESH C072194 000349 PDGF_BB -MESH D000199 000009 Actin -MESH D003576 000504 ETC_complex_IV -MESH D006657 000233 Histone -MESH D010749 000357 Phosphatase -MESH D011493 000364 PKC -MESH D011948 000461 TCR -MESH D014450 000503 ETC_complex_III -MESH D016695 000198 Glycosyltransferase -MESH D018808 000048 AP1 -MESH D018844 000092 CDK -MESH D020169 000081 Caspase -MESH D025261 000505 ETC_complex_V -MESH D042963 000502 ETC_complex_II -MESH D042967 000501 ETC_complex_I -MESH D046988 000394 Proteasome -NCIT C104194 000132 Cyclin_D -NCIT C104197 000133 Cyclin_E -NCIT C104199 000251 IKK_family -NCIT C104676 000473 TN -NCIT C105947 000281 MAP2K -NCIT C105952 000051 APOA -NCIT C107433 000338 PDE4 -NCIT C107559 000104 CK2 -NCIT C112049 000502 ETC_complex_II -NCIT C112051 000080 Carboxylesterase -NCIT C113839 000229 HIF -NCIT C116019 000044 AMPK_alpha -NCIT C118184 000501 ETC_complex_I -NCIT C118481 000024 ALDH -NCIT C118892 000174 FOXO -NCIT C120030 000481 Tryptase -NCIT C120493 000226 Hedgehog -NCIT C124129 000109 COL1 -NCIT C126114 000372 PLCG -NCIT C126122 000188 GPIb_IX_V -NCIT C129655 000484 TUBB -NCIT C16258 000009 Actin -NCIT C16264 000017 ADCY -NCIT C16272 000018 ADH -NCIT C16373 000074 Cadherin -NCIT C16375 000075 CALM -NCIT C16376 000161 ERK -NCIT C16376 000283 MAPK -NCIT C16377 000079 CAPN -NCIT C16448 000110 COL4 -NCIT C16479 000363 PKA -NCIT C16511 000141 DNA_polymerase_delta -NCIT C16641 000195 GST -NCIT C16650 000204 GTPase -NCIT C16653 000205 GUCY -NCIT C16676 000227 Hemoglobin -NCIT C16682 000220 HDAC -NCIT C16683 000234 Histone_H1 -NCIT C16684 000235 Histone_H2A -NCIT C16685 000237 Histone_H3 -NCIT C16686 000238 Histone_H4 -NCIT C16687 000233 Histone -NCIT C16692 000239 HLA_DR -NCIT C16748 000261 Integrins -NCIT C16965 000393 Protease -NCIT C16979 000366 PLA2 -NCIT C16981 000357 Phosphatase -NCIT C17017 000364 PKC -NCIT C17061 000404 RAS -NCIT C17062 000021 ADRB -NCIT C17065 000461 TCR -NCIT C17066 000143 DRD -NCIT C17078 000468 THR -NCIT C17219 000486 Tubulin -NCIT C17227 000490 Ubiquitin -NCIT C17270 000358 PI3K -NCIT C17274 000067 BMP -NCIT C17286 000120 CREB -NCIT C17293 000496 VEGFR -NCIT C17297 000168 FGFR -NCIT C17298 000182 GAP -NCIT C17322 000343 PDGFR -NCIT C17343 000479 Troponin_I -NCIT C17349 000130 Cyclin -NCIT C17380 000311 NFkappaB -NCIT C17450 000048 AP1 -NCIT C17458 000214 G_protein -NCIT C17487 000086 CD16 -NCIT C17494 000186 GEF -NCIT C17532 000403 RAR -NCIT C17534 000424 RXR -NCIT C17583 000249 IKB -NCIT C17660 000423 RTK -NCIT C17690 000230 HIF1 -NCIT C17763 000160 ERBB -NCIT C17766 000241 HSP90 -NCIT C17767 000092 CDK -NCIT C17903 000309 NFAT -NCIT C18153 000081 Caspase -NCIT C18162 000152 EIF2B -NCIT C18164 000291 MMP -NCIT C18239 000187 GPCR -NCIT C18308 000088 CD32 -NCIT C18434 000476 TOP2 -NCIT C18492 000094 CDKN -NCIT C18606 000158 Ephrin_receptor -NCIT C19275 000213 G_i_alpha -NCIT C19618 000453 STAT -NCIT C19836 000368 PLA2G4 -NCIT C19866 000386 PRC1_complex -NCIT C20448 000342 PDGF -NCIT C129646 000495 VEGF -NCIT C20456 000010 Activin -NCIT C20466 000099 Chemokine -NCIT C20493 000262 Interferon -NCIT C20495 000247 IFNB -NCIT C20506 000252 IL1 -NCIT C20514 000253 IL12 -NCIT C20591 000457 SWI_SNF -NCIT C2275 000219 hCG -NCIT C2276 000256 Inhibin -NCIT C2277 000257 Inhibin_A -NCIT C2278 000258 Inhibin_B -NCIT C25184 000275 LDH -NCIT C25186 000225 HDL -NCIT C26034 000504 ETC_complex_IV -NCIT C26233 000192 GRK -NCIT C26360 000161 ERK -NCIT C28687 000122 CRSP -NCIT C38041 000480 Troponin_T -NCIT C38897 000087 CD3 -NCIT C41625 000023 AKT -NCIT C736 000354 Pertussis_toxin -NCIT C94701 000031 AMPK -NCIT C95114 000181 Gamma_secretase -NCIT C95947 000416 RNApo_I -NCIT C95948 000417 RNApo_II -NCIT C96314 000293 mTORC1 -NCIT C96315 000294 mTORC2 -NXP FA:00078 000009 Actin -NXP FA:00093 000004 ACAD -NXP FA:00209 000463 TFAP2 -NXP FA:00406 000097 CEBP -NXP FA:00408 000173 FOS_family -NXP FA:00421 000385 PPP3R -NXP FA:00440 000075 CALM -NXP FA:00489 000083 CAV -NXP FA:00653 000106 CNKSR -NXP FA:00787 000127 CUL -NXP FA:00803 000337 PDE3 -NXP FA:00804 000338 PDE4 -NXP FA:00815 000130 Cyclin -NXP FA:00818 000132 Cyclin_D -NXP FA:00819 000133 Cyclin_E -NXP FA:00921 000153 EIF4A -NXP FA:01112 000157 ENO -NXP FA:01121 000159 EPN -NXP FA:01400 000211 G_gamma -NXP FA:01553 000190 GPX -NXP FA:01669 000195 GST -NXP FA:01729 000226 Hedgehog -NXP FA:01762 000235 Histone_H2A -NXP FA:01764 000237 Histone_H3 -NXP FA:01765 000238 Histone_H4 -NXP FA:01820 000252 IL1 -NXP FA:01869 000259 INS -NXP FA:02022 000275 LDH -NXP FA:02159 000434 SLC2A -NXP FA:02187 000284 MCM -NXP FA:02504 000316 NOS -NXP FA:02506 000317 Notch -NXP FA:02630 000324 P2RX -NXP FA:02632 000327 p53_family -NXP FA:02660 000332 PARV -NXP FA:02762 000156 ELA -NXP FA:02767 000481 Tryptase -NXP FA:02840 000366 PLA2 -NXP FA:03001 000376 PPP1 -NXP FA:03065 000364 PKC -NXP FA:03066 000398 RAC -NXP FA:03071 000031 AMPK -NXP FA:03072 000076 CAMK -NXP FA:03078 000362 PIM -NXP FA:03083 000124 CSNK1 -NXP FA:03087 000194 GSK3 -NXP FA:03091 000146 DYRK -NXP FA:03101 000104 CK2 -NXP FA:03104 000251 IKK_family -NXP FA:03114 000399 RAF -NXP FA:03124 000158 Ephrin_receptor -NXP FA:03128 000260 INSR -NXP FA:03129 000266 JAK -NXP FA:03130 000420 ROR -NXP FA:03131 000451 SRC -NXP FA:03483 000428 SAA -NXP FA:03579 000431 SERPINB -NXP FA:03661 000397 RAB -NXP FA:03663 000404 RAS -NXP FA:03668 000414 RHO -NXP FA:03672 000435 SLRP -NXP FA:03673 000436 SLRP_1 -NXP FA:03674 000437 SLRP_2 -NXP FA:03675 000438 SLRP_3 -NXP FA:03676 000439 SLRP_4 -NXP FA:03677 000440 SLRP_5 -NXP FA:03686 000444 SMC1 -NXP FA:03943 000460 TCF_LEF -NXP FA:03964 000473 TN -NXP FA:03989 000465 TGFB -NXP FA:04000 000487 TXN -NXP FA:04014 000470 TIAM -NXP FA:04239 000486 Tubulin -NXP FA:04243 000474 TNF -NXP FA:04276 000490 Ubiquitin -NXP FA:04282 000489 UBE2 -NXP FA:04686 000497 Wnt -NXP FA:04773 000401 RAP1 -PF PF00012 000244 HSPA -PF PF00022 000009 Actin -PF PF00028 000074 Cadherin -PF PF00066 000317 Notch -PF PF00071 000404 RAS -PF PF00110 000497 Wnt -PF PF00143 000262 Interferon -PF PF00146 000301 NADH_dehydrogenase -PF PF00167 000167 FGF -PF PF00178 000163 ETS -PF PF00183 000241 HSP90 -PF PF00219 000248 IGFBP -PF PF00229 000474 TNF -PF PF00235 000355 PFN -PF PF00244 000323 p14_3_3 -PF PF00255 000190 GPX -PF PF00277 000428 SAA -PF PF00320 000184 GATA -PF PF00322 000149 EDN -PF PF00340 000252 IL1 -PF PF00465 000018 ADH -PF PF00493 000284 MCM -PF PF00503 000209 G_alpha -PF PF00616 000407 RasGAP -PF PF00644 000331 PARP -PF PF00656 000081 Caspase -PF PF00864 000324 P2RX -PF PF00870 000327 p53_family -PF PF00888 000127 CUL -PF PF00963 000108 Cohesin -PF PF01146 000083 CAV -PF PF01442 000052 Apolipoprotein -PF PF01534 000177 FZD -PF PF01756 000007 ACOX -PF PF02046 000115 COX6A -PF PF02158 000318 NRG -PF PF02174 000264 IRS -PF PF02234 000094 CDKN -PF PF02238 000117 COX7A -PF PF02285 000119 COX8 -PF PF02297 000116 COX6B -PF PF02377 000145 DVL -PF PF02460 000333 Patched -PF PF02545 000279 MAF -PF PF02608 000067 BMP -PF PF02827 000365 PKI -PF PF02854 000155 EIF4G -PF PF02936 000114 COX4 -PF PF03039 000253 IL12 -PF PF03096 000307 NDRG -PF PF05392 000118 COX7B -PF PF08137 000145 DVL -PF PF08562 000121 CRISP -PF PF08841 000136 DDR -PF PF11413 000230 HIF1 -PF PF12483 000148 E3_Ub_ligase -PF PF15975 000170 FLOT -RE R-HSA-1031694 000089 CD64 -RE R-HSA-109631 000197 GTF2F -RE R-HSA-109633 000196 GTF2E -RE R-HSA-109782 000404 RAS -RE R-HSA-109783 000404 RAS -RE R-HSA-109796 000404 RAS -RE R-HSA-111854 000370 PLCB -RE R-HSA-111864 000212 G_i -RE R-HSA-111864 000213 G_i_alpha -RE R-HSA-111921 000390 PRKAR -RE R-HSA-111923 000390 PRKAR -RE R-HSA-111952 000336 PDE1 -RE R-HSA-111953 000336 PDE1 -RE R-HSA-111960 000338 PDE4 -RE R-HSA-114525 000208 G_12_alpha -RE R-HSA-114534 000215 G_q -RE R-HSA-114534 000216 G_q_alpha -RE R-HSA-114547 000207 G_12 -RE R-HSA-114556 000215 G_q -RE R-HSA-114556 000216 G_q_alpha -RE R-HSA-114617 000169 Fibrinogen -RE R-HSA-114618 000169 Fibrinogen -RE R-HSA-114657 000465 TGFB -RE R-HSA-114668 000188 GPIb_IX_V -RE R-HSA-1168365 000372 PLCG -RE R-HSA-1168621 000250 IKK_complex -RE R-HSA-1169086 000372 PLCG -RE R-HSA-1169089 000372 PLCG -RE R-HSA-1218829 000243 HSP90AA -RE R-HSA-1221657 000243 HSP90AA -RE R-HSA-1227956 000319 NRG_1_2 -RE R-HSA-1227957 000318 NRG -RE R-HSA-1234130 000229 HIF -RE R-HSA-1234147 000231 HIF_alpha -RE R-HSA-1236898 000089 CD64 -RE R-HSA-1236905 000089 CD64 -RE R-HSA-1247495 000319 NRG_1_2 -RE R-HSA-1248743 000319 NRG_1_2 -RE R-HSA-1250100 000326 p38 -RE R-HSA-1250102 000326 p38 -RE R-HSA-1268261 000161 ERK -RE R-HSA-1362227 000464 TFDP -RE R-HSA-139848 000324 P2RX -RE R-HSA-139933 000169 Fibrinogen -RE R-HSA-139934 000169 Fibrinogen -RE R-HSA-140586 000169 Fibrinogen -RE R-HSA-140812 000469 Thrombin_antithrombin -RE R-HSA-140871 000469 Thrombin_antithrombin -RE R-HSA-140874 000469 Thrombin_antithrombin -RE R-HSA-140919 000169 Fibrinogen -RE R-HSA-1445138 000323 p14_3_3 -RE R-HSA-1449672 000013 Activin_B -RE R-HSA-1449688 000256 Inhibin -RE R-HSA-1449698 000012 Activin_AB -RE R-HSA-1469978 000454 STAT5 -RE R-HSA-1504201 000145 DVL -RE R-HSA-157462 000133 Cyclin_E -RE R-HSA-162690 000189 GPIT -RE R-HSA-163538 000377 PPP1C -RE R-HSA-163679 000042 AMPK_A2B2G2 -RE R-HSA-163736 000042 AMPK_A2B2G2 -RE R-HSA-163747 000042 AMPK_A2B2G2 -RE R-HSA-165175 000482 TSC -RE R-HSA-165180 000482 TSC -RE R-HSA-1655720 000452 SREBF -RE R-HSA-1655725 000452 SREBF -RE R-HSA-1655726 000452 SREBF -RE R-HSA-1655730 000452 SREBF -RE R-HSA-1655732 000452 SREBF -RE R-HSA-1655734 000452 SREBF -RE R-HSA-165631 000502 ETC_complex_II -RE R-HSA-165990 000381 PPP2R_A -RE R-HSA-165997 000381 PPP2R_A -RE R-HSA-167023 000432 SHC -RE R-HSA-167204 000404 RAS -RE R-HSA-167215 000448 SOS -RE R-HSA-167409 000210 G_beta -RE R-HSA-167410 000212 G_i -RE R-HSA-167410 000213 G_i_alpha -RE R-HSA-167413 000212 G_i -RE R-HSA-167413 000213 G_i_alpha -RE R-HSA-167438 000212 G_i -RE R-HSA-167438 000213 G_i_alpha -RE R-HSA-167442 000211 G_gamma -RE R-HSA-1678828 000155 EIF4G -RE R-HSA-168113 000250 IKK_complex -RE R-HSA-169289 000161 ERK -RE R-HSA-169291 000161 ERK -RE R-HSA-170089 000131 Cyclin_A -RE R-HSA-170108 000091 CDC25 -RE R-HSA-170994 000400 RAL -RE R-HSA-170998 000400 RAL -RE R-HSA-171016 000326 p38 -RE R-HSA-171172 000443 SMAD2_3 -RE R-HSA-171182 000443 SMAD2_3 -RE R-HSA-173584 000072 C1 -RE R-HSA-173615 000072 C1 -RE R-HSA-173617 000072 C1 -RE R-HSA-173728 000278 MAC -RE R-HSA-174074 000131 Cyclin_A -RE R-HSA-174454 000411 RFC -RE R-HSA-177105 000443 SMAD2_3 -RE R-HSA-177656 000312 NFkappaB_1 -RE R-HSA-177662 000312 NFkappaB_1 -RE R-HSA-177663 000250 IKK_complex -RE R-HSA-179508 000025 ALDO -RE R-HSA-182582 000132 Cyclin_D -RE R-HSA-182700 000132 Cyclin_D -RE R-HSA-184196 000349 PDGF_BB -RE R-HSA-184198 000349 PDGF_BB -RE R-HSA-184203 000347 PDGF_AA -RE R-HSA-184204 000349 PDGF_BB -RE R-HSA-184206 000349 PDGF_BB -RE R-HSA-186769 000343 PDGFR -RE R-HSA-186769 000345 PDGFR_AB -RE R-HSA-186770 000343 PDGFR -RE R-HSA-186770 000345 PDGFR_AB -RE R-HSA-186791 000343 PDGFR -RE R-HSA-186791 000345 PDGFR_AB -RE R-HSA-186792 000343 PDGFR -RE R-HSA-186792 000345 PDGFR_AB -RE R-HSA-186799 000346 PDGFR_BB -RE R-HSA-186805 000346 PDGFR_BB -RE R-HSA-186816 000344 PDGFR_AA -RE R-HSA-186817 000344 PDGFR_AA -RE R-HSA-186821 000343 PDGFR -RE R-HSA-186821 000345 PDGFR_AB -RE R-HSA-187493 000133 Cyclin_E -RE R-HSA-189382 000240 HMOX -RE R-HSA-189828 000326 p38 -RE R-HSA-1911410 000055 ARRB -RE R-HSA-1911440 000317 Notch -RE R-HSA-1911472 000317 Notch -RE R-HSA-1911474 000317 Notch -RE R-HSA-1911547 000317 Notch -RE R-HSA-1911550 000317 Notch -RE R-HSA-195361 000495 VEGF -RE R-HSA-195376 000495 VEGF -RE R-HSA-196206 000379 PPP2 -RE R-HSA-198358 000194 GSK3 -RE R-HSA-198373 000194 GSK3 -RE R-HSA-198701 000161 ERK -RE R-HSA-198899 000090 CD8 -RE R-HSA-200408 000042 AMPK_A2B2G2 -RE R-HSA-200563 000005 ACC -RE R-HSA-201465 000070 BMP_receptor_type_II -RE R-HSA-201689 000145 DVL -RE R-HSA-201711 000104 CK2 -RE R-HSA-201725 000145 DVL -RE R-HSA-201779 000384 PPP3C -RE R-HSA-201798 000384 PPP3C -RE R-HSA-201804 000070 BMP_receptor_type_II -RE R-HSA-202052 000023 AKT -RE R-HSA-202072 000023 AKT -RE R-HSA-202074 000023 AKT -RE R-HSA-202088 000023 AKT -RE R-HSA-202513 000250 IKK_complex -RE R-HSA-202562 000250 IKK_complex -RE R-HSA-202877 000082 Caspase_3_7 -RE R-HSA-2029095 000372 PLCG -RE R-HSA-2029115 000494 VAV -RE R-HSA-203947 000353 PDK -RE R-HSA-206893 000011 Activin_A -RE R-HSA-2089970 000109 COL1 -RE R-HSA-212420 000317 Notch -RE R-HSA-2127310 000111 COL5 -RE R-HSA-2127389 000110 COL4 -RE R-HSA-2127422 000111 COL5 -RE R-HSA-2151208 000045 AMPK_beta -RE R-HSA-2151212 000046 AMPK_gamma -RE R-HSA-2151213 000044 AMPK_alpha -RE R-HSA-215989 000273 Laminin_111 -RE R-HSA-216001 000274 Laminin_332 -RE R-HSA-2176482 000443 SMAD2_3 -RE R-HSA-2187329 000443 SMAD2_3 -RE R-HSA-2187387 000443 SMAD2_3 -RE R-HSA-2213185 000142 DNM -RE R-HSA-2220790 000274 Laminin_332 -RE R-HSA-2316451 000046 AMPK_gamma -RE R-HSA-2317310 000023 AKT -RE R-HSA-2317317 000023 AKT -RE R-HSA-2317329 000023 AKT -RE R-HSA-2395330 000465 TGFB -RE R-HSA-2396039 000109 COL1 -RE R-HSA-2396161 000109 COL1 -RE R-HSA-2396179 000109 COL1 -RE R-HSA-2396183 000109 COL1 -RE R-HSA-2396256 000109 COL1 -RE R-HSA-2396260 000109 COL1 -RE R-HSA-2396334 000109 COL1 -RE R-HSA-2396451 000109 COL1 -RE R-HSA-2396456 000109 COL1 -RE R-HSA-2396478 000109 COL1 -RE R-HSA-2399520 000109 COL1 -RE R-HSA-2399659 000274 Laminin_332 -RE R-HSA-2400006 000023 AKT -RE R-HSA-2400013 000023 AKT -RE R-HSA-2422450 000161 ERK -RE R-HSA-2426131 000314 NFY -RE R-HSA-2426276 000349 PDGF_BB -RE R-HSA-2426371 000273 Laminin_111 -RE R-HSA-2428941 000109 COL1 -RE R-HSA-2445131 000264 IRS -RE R-HSA-2445139 000264 IRS -RE R-HSA-2457842 000323 p14_3_3 -RE R-HSA-2470478 000010 Activin -RE R-HSA-2470478 000012 Activin_AB -RE R-HSA-2470491 000010 Activin -RE R-HSA-2470491 000012 Activin_AB -RE R-HSA-2470494 000010 Activin -RE R-HSA-2470494 000012 Activin_AB -RE R-HSA-2530496 000172 FNT -RE R-HSA-2533911 000274 Laminin_332 -RE R-HSA-264974 000164 EXOC -RE R-HSA-2672035 000473 TN -RE R-HSA-2681744 000473 TN -RE R-HSA-2685653 000372 PLCG -RE R-HSA-2685656 000409 RASGRP -RE R-HSA-2990868 000101 Cholinesterase -RE R-HSA-2993807 000392 Propionyl_CoA_carboxylase -RE R-HSA-2993809 000392 Propionyl_CoA_carboxylase -RE R-HSA-3132719 000163 ETS -RE R-HSA-3132724 000163 ETS -RE R-HSA-3200029 000163 ETS -RE R-HSA-3238268 000497 Wnt -RE R-HSA-3238374 000497 Wnt -RE R-HSA-3247790 000497 Wnt -RE R-HSA-3247824 000497 Wnt -RE R-HSA-3247835 000497 Wnt -RE R-HSA-3299546 000460 TCF_LEF -RE R-HSA-3323122 000392 Propionyl_CoA_carboxylase -RE R-HSA-3323155 000392 Propionyl_CoA_carboxylase -RE R-HSA-3371429 000242 HSP90A -RE R-HSA-349716 000306 NCOR -RE R-HSA-3640819 000062 AXIN -RE R-HSA-3640837 000101 Cholinesterase -RE R-HSA-3640863 000062 AXIN -RE R-HSA-3656389 000161 ERK -RE R-HSA-374848 000215 G_q -RE R-HSA-374848 000216 G_q_alpha -RE R-HSA-376002 000003 ABL_family -RE R-HSA-3772407 000145 DVL -RE R-HSA-3772502 000062 AXIN -RE R-HSA-378941 000219 hCG -RE R-HSA-378947 000175 FSH -RE R-HSA-378969 000276 LH -RE R-HSA-380748 000349 PDGF_BB -RE R-HSA-380751 000349 PDGF_BB -RE R-HSA-380759 000348 PDGF_AB -RE R-HSA-380759 000349 PDGF_BB -RE R-HSA-380931 000031 AMPK -RE R-HSA-380934 000031 AMPK -RE R-HSA-380961 000031 AMPK -RE R-HSA-381204 000314 NFY -RE R-HSA-381844 000044 AMPK_alpha -RE R-HSA-381845 000044 AMPK_alpha -RE R-HSA-381851 000046 AMPK_gamma -RE R-HSA-381854 000045 AMPK_beta -RE R-HSA-381855 000482 TSC -RE R-HSA-381926 000342 PDGF -RE R-HSA-381930 000351 PDGF_DD -RE R-HSA-381935 000349 PDGF_BB -RE R-HSA-381936 000342 PDGF -RE R-HSA-381938 000349 PDGF_BB -RE R-HSA-381941 000350 PDGF_CC -RE R-HSA-3858467 000145 DVL -RE R-HSA-3858479 000145 DVL -RE R-HSA-387074 000349 PDGF_BB -RE R-HSA-388544 000149 EDN -RE R-HSA-390455 000085 CCT_complex -RE R-HSA-390474 000085 CCT_complex -RE R-HSA-390532 000478 Troponin_C -RE R-HSA-390541 000479 Troponin_I -RE R-HSA-390546 000480 Troponin_T -RE R-HSA-390583 000477 Troponin -RE R-HSA-390585 000477 Troponin -RE R-HSA-390587 000478 Troponin_C -RE R-HSA-390643 000021 ADRB -RE R-HSA-390664 000020 ADRA2 -RE R-HSA-390670 000021 ADRB -RE R-HSA-390700 000020 ADRA2 -RE R-HSA-392712 000349 PDGF_BB -RE R-HSA-399713 000191 GRIA -RE R-HSA-399987 000215 G_q -RE R-HSA-399987 000216 G_q_alpha -RE R-HSA-399992 000215 G_q -RE R-HSA-399992 000216 G_q_alpha -RE R-HSA-400000 000215 G_q -RE R-HSA-400000 000216 G_q_alpha -RE R-HSA-400008 000215 G_q -RE R-HSA-400008 000216 G_q_alpha -RE R-HSA-400062 000211 G_gamma -RE R-HSA-400093 000210 G_beta -RE R-HSA-416323 000191 GRIA -RE R-HSA-417004 000077 CAMK2_complex -RE R-HSA-417004 000078 CAMK2_family -RE R-HSA-418312 000430 SERCA -RE R-HSA-418379 000391 PRKG -RE R-HSA-418540 000340 PDE7 -RE R-HSA-418541 000341 PDE8 -RE R-HSA-418570 000207 G_12 -RE R-HSA-418570 000208 G_12_alpha -RE R-HSA-418572 000207 G_12 -RE R-HSA-418572 000208 G_12_alpha -RE R-HSA-419057 000419 ROCK -RE R-HSA-419160 000414 RHO -RE R-HSA-419161 000414 RHO -RE R-HSA-419164 000414 RHO -RE R-HSA-419294 000316 NOS -RE R-HSA-419346 000427 S1PR -RE R-HSA-419401 000427 S1PR -RE R-HSA-419619 000242 HSP90A -RE R-HSA-420516 000193 GRM -RE R-HSA-420519 000193 GRM -RE R-HSA-420974 000191 GRIA -RE R-HSA-421001 000191 GRIA -RE R-HSA-426070 000140 DGK -RE R-HSA-427905 000430 SERCA -RE R-HSA-428110 000374 PPAP2 -RE R-HSA-428475 000330 PAK -RE R-HSA-429349 000259 INS -RE R-HSA-429352 000259 INS -RE R-HSA-429384 000259 INS -RE R-HSA-429407 000259 INS -RE R-HSA-429472 000259 INS -RE R-HSA-429842 000153 EIF4A -RE R-HSA-430172 000494 VAV -RE R-HSA-432792 000077 CAMK2_complex -RE R-HSA-432792 000078 CAMK2_family -RE R-HSA-434632 000494 VAV -RE R-HSA-442272 000494 VAV -RE R-HSA-442295 000494 VAV -RE R-HSA-442734 000408 RASGRF -RE R-HSA-444796 000077 CAMK2_complex -RE R-HSA-444796 000078 CAMK2_family -RE R-HSA-445134 000333 Patched -RE R-HSA-445374 000077 CAMK2_complex -RE R-HSA-445374 000078 CAMK2_family -RE R-HSA-445744 000252 IL1 -RE R-HSA-446847 000142 DNM -RE R-HSA-446849 000329 P90RSK -RE R-HSA-447102 000253 IL12 -RE R-HSA-448866 000285 MEF2 -RE R-HSA-448868 000285 MEF2 -RE R-HSA-450226 000267 JNK -RE R-HSA-450253 000267 JNK -RE R-HSA-450289 000267 JNK -RE R-HSA-451402 000014 ACTN -RE R-HSA-452094 000454 STAT5 -RE R-HSA-4551456 000391 PRKG -RE R-HSA-4551462 000391 PRKG -RE R-HSA-4641132 000062 AXIN -RE R-HSA-4652685 000145 DVL -RE R-HSA-4687776 000419 ROCK -RE R-HSA-507919 000454 STAT5 -RE R-HSA-507929 000454 STAT5 -RE R-HSA-508012 000454 STAT5 -RE R-HSA-5082395 000242 HSP90A -RE R-HSA-5082406 000243 HSP90AA -RE R-HSA-5083623 000125 CSNK2 -RE R-HSA-5083624 000125 CSNK2 -RE R-HSA-5138439 000105 Clathrin -RE R-HSA-5138447 000105 Clathrin -RE R-HSA-517388 000177 FZD -RE R-HSA-5218789 000494 VAV -RE R-HSA-5262981 000250 IKK_complex -RE R-HSA-5323539 000460 TCF_LEF -RE R-HSA-5333713 000105 Clathrin -RE R-HSA-5336141 000047 Annexin_II_heterotetramer -RE R-HSA-5340329 000494 VAV -RE R-HSA-5358286 000226 Hedgehog -RE R-HSA-5358318 000226 Hedgehog -RE R-HSA-5358332 000226 Hedgehog -RE R-HSA-5362382 000226 Hedgehog -RE R-HSA-5362391 000226 Hedgehog -RE R-HSA-5610566 000390 PRKAR -RE R-HSA-5610568 000390 PRKAR -RE R-HSA-5610577 000017 ADCY -RE R-HSA-5610578 000017 ADCY -RE R-HSA-5618088 000242 HSP90A -RE R-HSA-5623453 000164 EXOC -RE R-HSA-5656056 000171 FLRT -RE R-HSA-5658216 000407 RasGAP -RE R-HSA-5658219 000449 SPRED -RE R-HSA-5672337 000482 TSC -RE R-HSA-5672686 000286 MEK -RE R-HSA-5672705 000286 MEK -RE R-HSA-5672708 000399 RAF -RE R-HSA-5672716 000286 MEK -RE R-HSA-5672721 000286 MEK -RE R-HSA-5672726 000399 RAF -RE R-HSA-5674134 000399 RAF -RE R-HSA-5674136 000399 RAF -RE R-HSA-5674338 000161 ERK -RE R-HSA-5674340 000161 ERK -RE R-HSA-5674341 000161 ERK -RE R-HSA-5674489 000286 MEK -RE R-HSA-5675361 000161 ERK -RE R-HSA-5675363 000161 ERK -RE R-HSA-5682664 000056 ATG4 -RE R-HSA-5693120 000064 BCKDC -RE R-HSA-5696998 000131 Cyclin_A -RE R-HSA-6783051 000131 Cyclin_A -RE R-HSA-6792583 000064 BCKDC -RE R-HSA-6793931 000276 LH -RE R-HSA-6793934 000276 LH -RE R-HSA-6798076 000327 p53_family -RE R-HSA-6798078 000327 p53_family -RE R-HSA-6802607 000404 RAS -RE R-HSA-6802608 000404 RAS -RE R-HSA-6805064 000125 CSNK2 -RE R-HSA-6805066 000104 CK2 -RE R-HSA-6805073 000125 CSNK2 -RE R-HSA-6805467 000031 AMPK -RE R-HSA-6813837 000133 Cyclin_E -RE R-HSA-6814207 000210 G_beta -RE R-HSA-6814413 000210 G_beta -RE R-HSA-6814694 000138 Desmoglein -RE R-HSA-68373 000133 Cyclin_E -RE R-HSA-68436 000411 RFC -RE R-HSA-68450 000141 DNA_polymerase_delta -RE R-HSA-68462 000421 RPA -RE R-HSA-69261 000091 CDC25 -RE R-HSA-70019 000064 BCKDC -RE R-HSA-70990 000502 ETC_complex_II -RE R-HSA-71025 000392 Propionyl_CoA_carboxylase -RE R-HSA-71026 000392 Propionyl_CoA_carboxylase -RE R-HSA-72526 000152 EIF2B -RE R-HSA-727820 000250 IKK_complex -RE R-HSA-74674 000259 INS -RE R-HSA-74688 000360 PI3K_p85 -RE R-HSA-749499 000215 G_q -RE R-HSA-749499 000216 G_q_alpha -RE R-HSA-75202 000131 Cyclin_A -RE R-HSA-77385 000259 INS -RE R-HSA-8847714 000138 Desmoglein -RE R-HSA-8848649 000079 CAPN -RE R-HSA-8848668 000079 CAPN -RE R-HSA-8849894 000170 FLOT -RE R-HSA-8850524 000210 G_beta -RE R-HSA-8852568 000278 MAC -RE R-HSA-8855211 000061 Augmin -RE R-HSA-8861873 000324 P2RX -RE R-HSA-8864040 000343 PDGFR -RE R-HSA-8864040 000345 PDGFR_AB -RE R-HSA-8864046 000346 PDGFR_BB -RE R-HSA-8864283 000463 TFAP2 -RE R-HSA-8864286 000463 TFAP2 -RE R-HSA-8865622 000454 STAT5 -RE R-HSA-8866229 000022 ADRBK -RE R-HSA-8868235 000142 DNM -RE R-HSA-8868609 000142 DNM -RE R-HSA-8870680 000169 Fibrinogen -RE R-HSA-8936837 000232 HIF_beta -RE R-HSA-8938866 000132 Cyclin_D -RE R-HSA-8941923 000095 CDKN1 -RE R-HSA-8942604 000095 CDKN1 -RE R-HSA-8944354 000460 TCF_LEF -RE R-HSA-8948131 000095 CDKN1 -RE R-HSA-8950122 000253 IL12 -RE R-HSA-8950228 000253 IL12 -RE R-HSA-8950694 000253 IL12 -RE R-HSA-8951427 000460 TCF_LEF -RE R-HSA-909688 000246 IFNA -RE R-HSA-936779 000057 ATP1A -RE R-HSA-936820 000058 ATP1B -RE R-HSA-976075 000148 E3_Ub_ligase -RE R-HSA-996770 000184 GATA -SIGNOR SIGNOR-PF1 000161 ERK -SIGNOR SIGNOR-PF10 000145 DVL -SIGNOR SIGNOR-PF11 000177 FZD -SIGNOR SIGNOR-PF12 000311 NFkappaB -SIGNOR SIGNOR-PF13 000330 PAK -SIGNOR SIGNOR-PF14 000418 ROBO -SIGNOR SIGNOR-PF15 000267 JNK -SIGNOR SIGNOR-PF16 000326 p38 -SIGNOR SIGNOR-PF17 000389 PRKAC -SIGNOR SIGNOR-PF18 000384 PPP3C -SIGNOR SIGNOR-PF2 000277 LPAR -SIGNOR SIGNOR-PF20 000472 TLR -SIGNOR SIGNOR-PF21 000458 TAOK -SIGNOR SIGNOR-PF22 000462 TEAD -SIGNOR SIGNOR-PF23 000168 FGFR -SIGNOR SIGNOR-PF24 000023 AKT -SIGNOR SIGNOR-PF25 000286 MEK -SIGNOR SIGNOR-PF26 000329 P90RSK -SIGNOR SIGNOR-PF27 000174 FOXO -SIGNOR SIGNOR-PF29 000445 SMURF -SIGNOR SIGNOR-PF3 000211 G_gamma -SIGNOR SIGNOR-PF30 000317 Notch -SIGNOR SIGNOR-PF31 000435 SLRP -SIGNOR SIGNOR-PF32 000451 SRC -SIGNOR SIGNOR-PF33 000187 GPCR -SIGNOR SIGNOR-PF34 000362 PIM -SIGNOR SIGNOR-PF35 000442 SMAD1_5_9 -SIGNOR SIGNOR-PF4 000210 G_beta -SIGNOR SIGNOR-PF5 000465 TGFB -SIGNOR SIGNOR-PF6 000044 AMPK_alpha -SIGNOR SIGNOR-PF7 000323 p14_3_3 -SIGNOR SIGNOR-PF8 000167 FGF -SIGNOR SIGNOR-PF9 000068 BMP_receptor diff --git a/famplex/resources/grounding_map.csv b/famplex/resources/grounding_map.csv new file mode 100644 index 000000000..e52c1bcb9 --- /dev/null +++ b/famplex/resources/grounding_map.csv @@ -0,0 +1,2834 @@ +"AMPK (alpha 1, beta 1, gamma 1)",FPLX,000032,AMPK_A1B1G1 +"AMPK (alpha 1, beta 1, gamma 2)",FPLX,000033,AMPK_A1B1G2 +"AMPK (alpha 1, beta 1, gamma 3)",FPLX,000034,AMPK_A1B1G3 +"AMPK (alpha 1, beta 2, gamma 1)",FPLX,000035,AMPK_A1B2G1 +"AMPK (alpha 1, beta 2, gamma 2)",FPLX,000036,AMPK_A1B2G2 +"AMPK (alpha 1, beta 2, gamma 3)",FPLX,000037,AMPK_A1B2G3 +"AMPK (alpha 2, beta 1, gamma 1)",FPLX,000038,AMPK_A2B1G1 +"AMPK (alpha 2, beta 1, gamma 2)",FPLX,000039,AMPK_A2B1G2 +"AMPK (alpha 2, beta 1, gamma 3)",FPLX,000040,AMPK_A2B1G3 +"AMPK (alpha 2, beta 2, gamma 1)",FPLX,000041,AMPK_A2B2G1 +"AMPK (alpha 2, beta 2, gamma 2)",FPLX,000042,AMPK_A2B2G2 +"AMPK (alpha 2, beta 2, gamma 3)",FPLX,000043,AMPK_A2B2G3 +"AMPK (α 1, β 1, γ 1)",FPLX,000032,AMPK_A1B1G1 +"AMPK (α 1, β 1, γ 2)",FPLX,000033,AMPK_A1B1G2 +"AMPK (α 1, β 1, γ 3)",FPLX,000034,AMPK_A1B1G3 +"AMPK (α 1, β 2, γ 1)",FPLX,000035,AMPK_A1B2G1 +"AMPK (α 1, β 2, γ 2)",FPLX,000036,AMPK_A1B2G2 +"AMPK (α 1, β 2, γ 3)",FPLX,000037,AMPK_A1B2G3 +"AMPK (α 2, β 1, γ 1)",FPLX,000038,AMPK_A2B1G1 +"AMPK (α 2, β 1, γ 2)",FPLX,000039,AMPK_A2B1G2 +"AMPK (α 2, β 1, γ 3)",FPLX,000040,AMPK_A2B1G3 +"AMPK (α 2, β 2, γ 1)",FPLX,000041,AMPK_A2B2G1 +"AMPK (α 2, β 2, γ 2)",FPLX,000042,AMPK_A2B2G2 +"AMPK (α 2, β 2, γ 3)",FPLX,000043,AMPK_A2B2G3 +"Glutamate receptors, ionotropic, kainate",FPLX,000269,Kainate_family +"Na(+),K(+)-ATPase",FPLX,000303,Na_K_ATPase +"Na,K-ATPase beta subunit",FPLX,000058,ATP1B +"Na,K-ATPase β subunit",FPLX,000058,ATP1B +"Na,K-ATPase",FPLX,000303,Na_K_ATPase +(9-1-1) complex,FPLX,000001,9_1_1 +14-3-3 proteins,FPLX,000323,p14_3_3 +14-3-3,FPLX,000323,p14_3_3 +14-3-3zeta,UP,P63104,1433Z_HUMAN +4E-BP1,UP,Q13541,4EBP1_HUMAN +4EBP,FPLX,000154,EIF4EBP +4EBP1,UP,Q13541,4EBP1_HUMAN +53BP1,UP,Q12888,TP53B_HUMAN +9-1-1 complex,FPLX,000001,9_1_1 +9-1-1,FPLX,000001,9_1_1 +a-adrenoreceptor,FPLX,000019,ADRA +a-cathenin,FPLX,000126,CTNNA +A2t,FPLX,000047,Annexin_II_heterotetramer +ABA,PUBCHEM,5280896, +ABA,CHEBI,CHEBI:2365,(+)-abscisic acid +Abeta,UP,P05067,A4_HUMAN +Abeta,CHEBI,CHEBI:64645,amyloid-beta +Abi1,UP,Q8IZP0,ABI1_HUMAN +ABL family,FPLX,000003,ABL_family +ABL,FPLX,000003,ABL_family +Abl,UP,P00519,ABL1_HUMAN +AC,MESH,D000230,Adenocarcinoma +AC,UP,Q08828,ADCY1_HUMAN +ACAD,FPLX,000004,ACAD +ACC,FPLX,000005,ACC +ACCs,FPLX,000005,ACC +Acetate-CoA ligase,FPLX,000006,Acetyl_CoA_synthetase +acetyl CoA ligase,FPLX,000006,Acetyl_CoA_synthetase +acetyl CoA synthase,FPLX,000006,Acetyl_CoA_synthetase +Acetyl Coenzyme A Carboxylase,FPLX,000005,ACC +Acetyl-CoA carboxylase,FPLX,000005,ACC +acetyl-CoA carboxylase,FPLX,000005,ACC +Acetyl-CoA synthetase,FPLX,000006,Acetyl_CoA_synthetase +acetyl-CoA synthetase,FPLX,000006,Acetyl_CoA_synthetase +acetyl-coenzyme A synthase,FPLX,000006,Acetyl_CoA_synthetase +acetylcholine receptor,FPLX,000102,CHRM +Ack1,UP,Q07912,ACK1_HUMAN +ACS,FPLX,000006,Acetyl_CoA_synthetase +Acsl,FPLX,000008,ACSL +actin filament,FPLX,000009,Actin +actin,FPLX,000009,Actin +actinin,FPLX,000014,ACTN +actins,FPLX,000009,Actin +Activin A protein,FPLX,000011,Activin_A +Activin A,FPLX,000011,Activin_A +activin A,FPLX,000011,Activin_A +activin AB,FPLX,000012,Activin_AB +activin protein,FPLX,000010,Activin +Activin,FPLX,000010,Activin +activin,FPLX,000010,Activin +activin-A,FPLX,000011,Activin_A +activin-B,FPLX,000013,Activin_B +activinA,FPLX,000011,Activin_A +activins,FPLX,000010,Activin +acyl CoA dehydrogenase,FPLX,000004,ACAD +acyl-CoA dehydrogenase,FPLX,000004,ACAD +Acyl-CoA Oxidase,FPLX,000007,ACOX +acyl-CoA oxidases,FPLX,000007,ACOX +Adaptor Protein 2 complex,FPLX,000015,Adaptor_protein_II +adaptor protein complex 2,FPLX,000015,Adaptor_protein_II +adaptor protein complex 3,FPLX,000016,Adaptor_protein_III +adenylate cyclase,FPLX,000017,ADCY +adenylyl cyclase,FPLX,000017,ADCY +adhesion,GO,GO:0007155,cell adhesion +adhesion,MESH,D002448,Cell Adhesion +adiponectin,UP,Q15848,ADIPO_HUMAN +ADP,CHEBI,CHEBI:16761,ADP +ADP,PUBCHEM,6022, +ADP ribosylation factor,FPLX,000053,ARF_GTPase_family +afatinib,PUBCHEM,10184653, +afatinib,LINCS,10133-101, +afatinib,CHEBI,CHEBI:61390,afatinib +AHR,UP,P35869,AHR_HUMAN +AICAR,PUBCHEM,65110, +AICAR,CHEBI,CHEBI:18406,AICA ribonucleotide +AKT family,FPLX,000023,AKT +AKT,FPLX,000023,AKT +Akt,FPLX,000023,AKT +AKT1,UP,P31749,AKT1_HUMAN +Akt1,UP,P31749,AKT1_HUMAN +AKT2,UP,P31751,AKT2_HUMAN +Akt2,UP,P31751,AKT2_HUMAN +alcohol dehydrogenase,FPLX,000018,ADH +alcohol,PUBCHEM,702, +alcohol,CHEBI,CHEBI:16236,ethanol +alcohol,HMDB,HMDB00108, +aldehyde dehydrogenase (NAD+),FPLX,000024,ALDH +Aldehyde dehydrogenase,FPLX,000024,ALDH +aldehyde dehydrogenase,FPLX,000024,ALDH +ALDH,FPLX,000024,ALDH +ALDO,FPLX,000025,ALDO +aldosterone,CHEBI,CHEBI:27584,aldosterone +aldosterone,PUBCHEM,5839, +ALG10,FPLX,000026,ALG10 +ALIX,HGNC,8766,PDCD6IP +ALIX,UP,Q8WUM4,PDC6I_HUMAN +ALK,UP,Q9UM73,ALK_HUMAN +alkali myosin light chains,FPLX,000297,MYL_alkali +alpha adrenoceptor,FPLX,000019,ADRA +alpha catenin,FPLX,000126,CTNNA +alpha tubulin,FPLX,000483,TUBA +alpha(2)-adrenoceptors,FPLX,000020,ADRA2 +alpha(2)-ARs,FPLX,000020,ADRA2 +alpha-adrenergic receptor,FPLX,000019,ADRA +alpha-adrenoreceptor,FPLX,000019,ADRA +alpha-adrenoreceptors,FPLX,000019,ADRA +alpha-catenin,FPLX,000126,CTNNA +alpha1 adrenoceptor,FPLX,000019,ADRA +"Alpha-1,2-glucosyltransferase",FPLX,000026,ALG10 +"Alpha-1,2-glucosyltransferases",FPLX,000026,ALG10 +"alpha-1,2-glucosyltransferase",FPLX,000026,ALG10 +"alpha-1,2-glucosyltransferases",FPLX,000026,ALG10 +"Alpha-1,3-glucosyltransferase",FPLX,000029,ALG6_family +"Alpha-1,3-glucosyltransferases",FPLX,000029,ALG6_family +"alpha-1,3-glucosyltransferase",FPLX,000029,ALG6_family +"alpha-1,3-glucosyltransferases",FPLX,000029,ALG6_family +"Alpha-1,4-glucosyltransferase",FPLX,000029,ALG6_family +"Alpha-1,4-glucosyltransferases",FPLX,000029,ALG6_family +"alpha-1,4-glucosyltransferase",FPLX,000029,ALG6_family +"alpha-1,4-glucosyltransferases",FPLX,000029,ALG6_family +alpha1beta1gamma1,FPLX,000032,AMPK_A1B1G1 +alpha1beta1gamma2,FPLX,000033,AMPK_A1B1G2 +alpha1beta1gamma3,FPLX,000034,AMPK_A1B1G3 +alpha1beta2gamma1,FPLX,000035,AMPK_A1B2G1 +alpha1beta2gamma2,FPLX,000036,AMPK_A1B2G2 +alpha2 adrenoceptor,FPLX,000020,ADRA2 +alpha2-AR,FPLX,000020,ADRA2 +alpha2beta1 integrin,FPLX,000261,Integrins +alpha2beta1gamma1,FPLX,000038,AMPK_A2B1G1 +alpha2beta2gamma1,FPLX,000041,AMPK_A2B2G1 +alpha2beta2gamma2,FPLX,000042,AMPK_A2B2G2 +alpha2beta2gamma3,FPLX,000043,AMPK_A2B2G3 +ALS,UP,P35858,ALS_HUMAN +AM,HGNC,259,ADM +AM,UP,P35318,ADML_HUMAN +AM,MESH,D000650,Amnion +AMG655,MESH,C554537,conatumumab +AMLC,FPLX,000297,MYL_alkali +AMP,HMDB,HMDB00045, +AMP,CHEBI,CHEBI:16027,adenosine 5'-monophosphate +AMP,PUBCHEM,6083, +AMPA glutamate receptor,FPLX,000191,GRIA +AMPA receptor,FPLX,000191,GRIA +AMPA-R,FPLX,000191,GRIA +AMPA-subtype ionotropic glutamate receptors,FPLX,000191,GRIA +AMPAR,FPLX,000191,GRIA +AMPARs,FPLX,000191,GRIA +AMPK (A1/B1/G1),FPLX,000032,AMPK_A1B1G1 +AMPK (A1/B1/G2),FPLX,000033,AMPK_A1B1G2 +AMPK (A1/B1/G3),FPLX,000034,AMPK_A1B1G3 +AMPK (A1/B2/G1),FPLX,000035,AMPK_A1B2G1 +AMPK (A1/B2/G2),FPLX,000036,AMPK_A1B2G2 +AMPK (A1/B2/G3),FPLX,000037,AMPK_A1B2G3 +AMPK (A2/B1/G1),FPLX,000038,AMPK_A2B1G1 +AMPK (A2/B1/G2),FPLX,000039,AMPK_A2B1G2 +AMPK (A2/B1/G3),FPLX,000040,AMPK_A2B1G3 +AMPK (A2/B2/G1),FPLX,000041,AMPK_A2B2G1 +AMPK (A2/B2/G2),FPLX,000042,AMPK_A2B2G2 +AMPK (A2/B2/G3),FPLX,000043,AMPK_A2B2G3 +AMPK a1b1g1,FPLX,000032,AMPK_A1B1G1 +AMPK a1b1g2,FPLX,000033,AMPK_A1B1G2 +AMPK a1b1g3,FPLX,000034,AMPK_A1B1G3 +AMPK a1b2g1,FPLX,000035,AMPK_A1B2G1 +AMPK a1b2g2,FPLX,000036,AMPK_A1B2G2 +AMPK a2b1g1,FPLX,000038,AMPK_A2B1G1 +AMPK a2b2g1,FPLX,000041,AMPK_A2B2G1 +AMPK a2b2g2,FPLX,000042,AMPK_A2B2G2 +AMPK a2b2g3,FPLX,000043,AMPK_A2B2G3 +AMPK alpha1beta1gamma1,FPLX,000032,AMPK_A1B1G1 +AMPK alpha1beta1gamma2,FPLX,000033,AMPK_A1B1G2 +AMPK alpha1beta1gamma3,FPLX,000034,AMPK_A1B1G3 +AMPK alpha1beta2gamma1,FPLX,000035,AMPK_A1B2G1 +AMPK alpha1beta2gamma2,FPLX,000036,AMPK_A1B2G2 +AMPK alpha1beta2gamma3,FPLX,000037,AMPK_A1B2G3 +AMPK alpha2beta1gamma1,FPLX,000038,AMPK_A2B1G1 +AMPK alpha2beta1gamma2,FPLX,000039,AMPK_A2B1G2 +AMPK alpha2beta1gamma3,FPLX,000040,AMPK_A2B1G3 +AMPK alpha2beta2gamma1,FPLX,000041,AMPK_A2B2G1 +AMPK alpha2beta2gamma2,FPLX,000042,AMPK_A2B2G2 +AMPK alpha2beta2gamma3,FPLX,000043,AMPK_A2B2G3 +AMPK α1β1γ1,FPLX,000032,AMPK_A1B1G1 +AMPK α1β1γ2,FPLX,000033,AMPK_A1B1G2 +AMPK α1β1γ3,FPLX,000034,AMPK_A1B1G3 +AMPK α1β2γ1,FPLX,000035,AMPK_A1B2G1 +AMPK α1β2γ2,FPLX,000036,AMPK_A1B2G2 +AMPK α1β2γ3,FPLX,000037,AMPK_A1B2G3 +AMPK α2β1γ1,FPLX,000038,AMPK_A2B1G1 +AMPK α2β1γ2,FPLX,000039,AMPK_A2B1G2 +AMPK α2β1γ3,FPLX,000040,AMPK_A2B1G3 +AMPK α2β2γ1,FPLX,000041,AMPK_A2B2G1 +AMPK α2β2γ2,FPLX,000042,AMPK_A2B2G2 +AMPK α2β2γ3,FPLX,000043,AMPK_A2B2G3 +AMPK,FPLX,000031,AMPK +AMPK-alpha1,UP,Q13131,AAPK1_HUMAN +AMPK-alpha2,UP,P54646,AAPK2_HUMAN +AMPK-α1,UP,Q13131,AAPK1_HUMAN +AMPK-α2,UP,P54646,AAPK2_HUMAN +AMPKalpha,FPLX,000044,AMPK_alpha +AMPKalpha1 catalytic domain,UP,Q13131,AAPK1_HUMAN +AMPKalpha1,UP,Q13131,AAPK1_HUMAN +AMPKα,FPLX,000044,AMPK_alpha +AMPKα1 catalytic domain,UP,Q13131,AAPK1_HUMAN +AMPKα1,UP,Q13131,AAPK1_HUMAN +amyloid beta,UP,P05067,A4_HUMAN +amyloid beta,CHEBI,CHEBI:64645,amyloid-beta +amyloid β,UP,P05067,A4_HUMAN +amyloid β,CHEBI,CHEBI:64645,amyloid-beta +Ang II,UP,P01019,ANGT_HUMAN +AngII,UP,P01019,ANGT_HUMAN +angiogenesis,GO,GO:0001525,angiogenesis +angiogenesis,MESH,D018919,"Neovascularization, Physiologic" +annexin A2 heterotetramer,FPLX,000047,Annexin_II_heterotetramer +annexin II heterotetramer,FPLX,000047,Annexin_II_heterotetramer +ANXA2 heterotetramer,FPLX,000047,Annexin_II_heterotetramer +AP-1,FPLX,000048,AP1 +AP-2 adaptor complex,FPLX,000015,Adaptor_protein_II +AP-2 complex,FPLX,000015,Adaptor_protein_II +AP-2 transcription factor,FPLX,000463,TFAP2 +AP-2,FPLX,000015,Adaptor_protein_II +AP-3,FPLX,000016,Adaptor_protein_III +AP1,FPLX,000048,AP1 +AP2 adaptor complex,FPLX,000015,Adaptor_protein_II +AP2 clathrin adaptor complex,FPLX,000015,Adaptor_protein_II +AP2 complex,FPLX,000015,Adaptor_protein_II +AP2,FPLX,000015,Adaptor_protein_II +AP3,FPLX,000016,Adaptor_protein_III +Apaf-1,UP,O14727,APAF_HUMAN +APC,UP,P25054,APC_HUMAN +APC/C,FPLX,000050,APC_C +apigenin,CHEBI,CHEBI:18388,apigenin +apigenin,PUBCHEM,5280443, +ApoA,FPLX,000051,APOA +apoA,FPLX,000051,APOA +apocynin,CHEBI,CHEBI:2781,apocynin +apocynin,PUBCHEM,2214, +apolipoprotein (a),FPLX,000051,APOA +apolipoprotein A,FPLX,000051,APOA +apolipoprotein(A),FPLX,000051,APOA +apolipoprotein(a),FPLX,000051,APOA +Apolipoprotein,FPLX,000052,Apolipoprotein +apolipoprotein,FPLX,000052,Apolipoprotein +apolipoproteins,FPLX,000052,Apolipoprotein +Apoptosis,GO,GO:0006915,apoptotic process +Apoptosis,MESH,D017209,Apoptosis +apoptosis,GO,GO:0006915,apoptotic process +apoptosis,MESH,D017209,Apoptosis +AR,UP,P10275,ANDR_HUMAN +ARF,FPLX,000053,ARF_GTPase_family +ARF,UP,Q8N726,ARF_HUMAN +Arf,UP,Q8N726,ARF_HUMAN +Arp2/3,FPLX,000054,Arp2_3_protein +Arsenic trioxide,CHEBI,CHEBI:30621,diarsenic trioxide +Arsenic trioxide,PUBCHEM,518605, +arsenic,PUBCHEM,5359596, +arsenic,CHEBI,CHEBI:27563,arsenic atom +arsenite,CHEBI,CHEBI:29866,arsenite(3-) +arsenite,PUBCHEM,544, +artemisinin,CHEBI,CHEBI:223316,(+)-artemisinin +artemisinin,PUBCHEM,68827, +ASK1,UP,Q99683,M3K5_HUMAN +aspirin,PUBCHEM,2244, +aspirin,CHEBI,CHEBI:15365,acetylsalicylic acid +ASPP1,UP,Q96KQ4,ASPP1_HUMAN +ASPP2,UP,Q13625,ASPP2_HUMAN +ATF2,UP,P15336,ATF2_HUMAN +ATG4,FPLX,000056,ATG4 +Atg4,FPLX,000056,ATG4 +ATM,UP,Q13315,ATM_HUMAN +ATP synthase H + transporting mitochondrial F0 complex subunit G,FPLX,000059,ATP5G +ATP synthase,FPLX,000060,ATP_synthase +ATP,HMDB,HMDB00538, +ATP,PUBCHEM,5957, +ATP,CHEBI,CHEBI:15422,ATP +ATP1A,FPLX,000057,ATP1A +ATP1B,FPLX,000058,ATP1B +ATPase Na+/K+ transporting subunit alpha,FPLX,000057,ATP1A +ATPase Na+/K+ transporting subunit beta,FPLX,000057,ATP1A +ATPase Na+/K+ transporting subunit α,FPLX,000057,ATP1A +ATPase Na+/K+ transporting subunit β,FPLX,000057,ATP1A +ATR,UP,Q13535,ATR_HUMAN +ATRA,CHEBI,CHEBI:15367,all-trans-retinoic acid +ATRA,PUBCHEM,444795, +autophagic cell death,GO,GO:0048102,autophagic cell death +Autophagy,GO,GO:0006914,autophagy +Autophagy,MESH,D001343,Autophagy +autophagy,GO,GO:0006914,autophagy +autophagy,MESH,D001343,Autophagy +Axin,FPLX,000062,AXIN +AZD6244,CHEBI,CHEBI:90227,selumetinib +AZD6244,PUBCHEM,10127622, +Aβ,UP,P05067,A4_HUMAN +Aβ,CHEBI,CHEBI:64645,amyloid-beta +B3GAT,FPLX,000063,B3GAT +b-adrenergic receptor,FPLX,000021,ADRB +b-arrestin,FPLX,000055,ARRB +B-Raf,UP,P15056,BRAF_HUMAN +b-receptors,FPLX,000021,ADRB +B1,UP,O43157,PLXB1_HUMAN +B1,UP,P14635,CCNB1_HUMAN +BAD,UP,Q92934,BAD_HUMAN +Bad,UP,Q92934,BAD_HUMAN +Bak,UP,Q16611,BAK_HUMAN +Bam32,UP,Q9UN19,DAPP1_HUMAN +BARK,FPLX,000022,ADRBK +barrestins,FPLX,000055,ARRB +BAX,UP,Q07812,BAX_HUMAN +Bax,UP,Q07812,BAX_HUMAN +BCKDC,FPLX,000064,BCKDC +BCKDH,FPLX,000064,BCKDC +BCL-2,UP,P10415,BCL2_HUMAN +Bcl-2,UP,P10415,BCL2_HUMAN +bcl-2,UP,P10415,BCL2_HUMAN +Bcl-3,HGNC,998,BCL3 +Bcl-xL,UP,Q07817,B2CL1_HUMAN +BCL2,UP,P10415,BCL2_HUMAN +Bcl2,UP,P10415,BCL2_HUMAN +BCR,UP,P11274,BCR_HUMAN +Beclin-1,UP,Q14457,BECN1_HUMAN +berberine,CHEBI,CHEBI:16118,berberine +berberine,PUBCHEM,2353, +"Beta-1,3-glucuronyltransferase",FPLX,000063,B3GAT +"Beta-1,3-glucuronyltransferases",FPLX,000063,B3GAT +"beta-1,3-glucuronyltransferase",FPLX,000063,B3GAT +"beta-1,3-glucuronyltransferases",FPLX,000063,B3GAT +Beta 3-glycosyltransferase,FPLX,000065,Beta_3_4_GTF +Beta 3-glycosyltransferases,FPLX,000065,Beta_3_4_GTF +beta 3-glycosyltransferase,FPLX,000065,Beta_3_4_GTF +beta 3-glycosyltransferases,FPLX,000065,Beta_3_4_GTF +Beta 4-glycosyltransferase,FPLX,000065,Beta_3_4_GTF +Beta 4-glycosyltransferases,FPLX,000065,Beta_3_4_GTF +beta 4-glycosyltransferase,FPLX,000065,Beta_3_4_GTF +beta 4-glycosyltransferases,FPLX,000065,Beta_3_4_GTF +beta adrenergic receptor kinase,FPLX,000022,ADRBK +beta interferons,FPLX,000247,IFNB +Beta Tubulin,FPLX,000484,TUBB +Beta tubulin,FPLX,000484,TUBB +beta Tubulin,FPLX,000484,TUBB +beta tubulin,FPLX,000484,TUBB +beta-adrenergic receptor,FPLX,000021,ADRB +beta-adrenoreceptor,FPLX,000021,ADRB +beta-catenin,UP,P35222,CTNB1_HUMAN +beta-TrCP,UP,Q9Y297,FBW1A_HUMAN +Beta-Tubulin,FPLX,000484,TUBB +Beta-tubulin,FPLX,000484,TUBB +beta-Tubulin,FPLX,000484,TUBB +beta-tubulin,FPLX,000484,TUBB +betaAR,FPLX,000021,ADRB +betaARK,FPLX,000022,ADRBK +BEZ235,PUBCHEM,11977753, +BEZ235,CHEBI,CHEBI:71952,dactolisib +bFGF,UP,P09038,FGF2_HUMAN +Bid,UP,P55957,BID_HUMAN +BIM,UP,O43521,B2L11_HUMAN +Bim,UP,O43521,B2L11_HUMAN +biosynthesis,GO,GO:0009058,biosynthetic process +BIRs,FPLX,000066,BIRC +BITC,PUBCHEM,2346, +BITC,CHEBI,CHEBI:17484,benzyl isothiocyanate +BMF,UP,Q96LC9,BMF_HUMAN +BMI1,UP,P35226,BMI1_HUMAN +BMP Receptor Type I,FPLX,000069,BMP_receptor_type_I +BMP Receptor Type II,FPLX,000070,BMP_receptor_type_II +BMP type I receptor,FPLX,000069,BMP_receptor_type_I +BMP type II receptor,FPLX,000070,BMP_receptor_type_II +BMP,FPLX,000067,BMP +BMP9,UP,Q9UK05,GDF2_HUMAN +bone morphogenetic protein I receptor,FPLX,000069,BMP_receptor_type_I +bone morphogenetic protein receptor 1,FPLX,000069,BMP_receptor_type_I +bone morphogenetic protein receptor 2,FPLX,000070,BMP_receptor_type_II +bone morphogenetic protein receptor type I,FPLX,000069,BMP_receptor_type_I +bone morphogenetic protein receptor type II,FPLX,000070,BMP_receptor_type_II +bone morphogenetic protein type I receptors,FPLX,000069,BMP_receptor_type_I +bone morphogenetic protein type II receptors,FPLX,000070,BMP_receptor_type_II +bortezomib,CHEBI,CHEBI:52717,bortezomib +bortezomib,PUBCHEM,387447, +BPA,CHEBI,CHEBI:33216,bisphenol A +BPA,PUBCHEM,6623, +BRAF,UP,P15056,BRAF_HUMAN +branched-chain alpha-keto acid dehydrogenase complex,FPLX,000064,BCKDC +branched-chain alpha-ketoacid dehydrogenase complex,FPLX,000064,BCKDC +branched-chain α-keto acid dehydrogenase complex,FPLX,000064,BCKDC +branched-chain α-ketoacid dehydrogenase complex,FPLX,000064,BCKDC +BRCA,FPLX,000071,BRCA +BRCA1,UP,P38398,BRCA1_HUMAN +BRCA2,UP,P51587,BRCA2_HUMAN +BRI,FPLX,000069,BMP_receptor_type_I +BRII,FPLX,000070,BMP_receptor_type_II +BRSK1,UP,Q8TDC3,BRSK1_HUMAN +BRSK2,UP,Q8IWQ3,BRSK2_HUMAN +Bub1,UP,O43683,BUB1_HUMAN +BubR1,UP,O60566,BUB1B_HUMAN +butein,CHEBI,CHEBI:3237,butein +butein,PUBCHEM,5281222, +c-Abl Kinase,UP,P00519,ABL1_HUMAN +c-Abl,UP,P00519,ABL1_HUMAN +c-Cbl protein,UP,P22681,CBL_HUMAN +c-Cbl,UP,P22681,CBL_HUMAN +c-FLIP,UP,O15519,CFLAR_HUMAN +c-Fos,UP,P01100,FOS_HUMAN +c-fos,UP,P01100,FOS_HUMAN +c-JNK,FPLX,000267,JNK +c-Jun N-terminal kinase,FPLX,000267,JNK +c-Jun NH2-terminal kinase,FPLX,000267,JNK +c-Jun,UP,P05412,JUN_HUMAN +c-jun,UP,P05412,JUN_HUMAN +C-MAF,UP,O75444,MAF_HUMAN +c-MAF,UP,O75444,MAF_HUMAN +c-Maf,UP,O75444,MAF_HUMAN +c-maf,UP,O75444,MAF_HUMAN +c-MET,HGNC,7029,MET +c-met,HGNC,7029,MET +c-Met,UP,P08581,MET_HUMAN +c-Myb,UP,P10242,MYB_HUMAN +c-myc oncogene,UP,P01106,MYC_HUMAN +c-myc proteins,UP,P01106,MYC_HUMAN +c-MYC,UP,P01106,MYC_HUMAN +c-Myc,UP,P01106,MYC_HUMAN +c-myc,UP,P01106,MYC_HUMAN +C-PARP,UP,P09874,PARP1_HUMAN +c-Raf,UP,P04049,RAF1_HUMAN +c-Rel,HGNC,9954,REL +c-src,HGNC,11283,SRC +c-Src,UP,P12931,SRC_HUMAN +C/EBP,FPLX,000097,CEBP +C/EBPalpha,UP,P49715,CEBPA_HUMAN +C/EBPbeta,UP,P17676,CEBPB_HUMAN +C/EBPβ,UP,P17676,CEBPB_HUMAN +C/EBPα,UP,P49715,CEBPA_HUMAN +c1 complex,FPLX,000072,C1 +C1,FPLX,000072,C1 +C1-complex,FPLX,000072,C1 +C1q,FPLX,000073,C1q +Ca(2+)-calmodulin-dependent protein kinase II,FPLX,000077,CAMK2_complex +Ca(2+)/calmodulin-dependent kinase II,FPLX,000077,CAMK2_complex +Ca,HMDB,HMDB00464, +Ca,CHEBI,CHEBI:29108,calcium(2+) +Ca,PUBCHEM,271, +cadherin,FPLX,000074,Cadherin +caffeine,PUBCHEM,2519, +caffeine,CHEBI,CHEBI:27732,caffeine +Calcineurin catalytic subunit,FPLX,000384,PPP3C +Calcineurin regulatory subunit,FPLX,000385,PPP3R +calcineurin,FPLX,000383,PPP3 +calcium,HMDB,HMDB00464, +calcium,CHEBI,CHEBI:29108,calcium(2+) +calcium,PUBCHEM,271, +Calmodulin,FPLX,000075,CALM +calmodulin,FPLX,000075,CALM +calmodulindependent kinase II,FPLX,000078,CAMK2_family +calpain,FPLX,000079,CAPN +CaM kinase II,FPLX,000077,CAMK2_complex +CaM,FPLX,000075,CALM +CaMK family,FPLX,000076,CAMK +CaMK II,FPLX,000077,CAMK2_complex +CaMK,FPLX,000076,CAMK +CAMK2,FPLX,000078,CAMK2_family +CaMK2,FPLX,000078,CAMK2_family +CaMKII,FPLX,000077,CAMK2_complex +CAMKII,FPLX,000078,CAMK2_family +cAMP,PUBCHEM,6076, +cAMP,CHEBI,CHEBI:17489,"3',5'-cyclic AMP" +cAMP,HMDB,HMDB00058, +cAMP-dependent PK,FPLX,000363,PKA +cAMP-dependent protein kinase,FPLX,000363,PKA +CaN,FPLX,000383,PPP3 +CAP23,UP,P80723,BASP1_HUMAN +CAPE,PUBCHEM,5281787, +CAPE,CHEBI,CHEBI:8062,phenethyl caffeate +capsaicin,PUBCHEM,1548943, +capsaicin,CHEBI,CHEBI:3374,capsaicin +carboxylesterase,FPLX,000080,Carboxylesterase +carboxylesterases,FPLX,000080,Carboxylesterase +CARP-1,UP,Q8IX12,CCAR1_HUMAN +Cas,UP,P56945,BCAR1_HUMAN +Casein kinase 1,FPLX,000124,CSNK1 +casein kinase 1,FPLX,000124,CSNK1 +casein kinase 2,FPLX,000104,CK2 +casein kinase I,FPLX,000124,CSNK1 +casein kinase II complex,FPLX,000104,CK2 +casein kinase II,FPLX,000104,CK2 +caspase 3,UP,P42574,CASP3_HUMAN +caspase 8,UP,Q14790,CASP8_HUMAN +caspase,FPLX,000081,Caspase +caspase-1,UP,P29466,CASP1_HUMAN +Caspase-3,UP,P42574,CASP3_HUMAN +caspase-3,UP,P42574,CASP3_HUMAN +caspase-3/7,FPLX,000082,Caspase_3_7 +caspase-8,UP,Q14790,CASP8_HUMAN +caspase-9,UP,P55211,CASP9_HUMAN +caspases,FPLX,000081,Caspase +catalase,UP,P04040,CATA_HUMAN +catalytic subunit of calcineurin,FPLX,000384,PPP3C +catenin alpha,FPLX,000126,CTNNA +catenin α,FPLX,000126,CTNNA +Caveolin,FPLX,000083,CAV +caveolin,FPLX,000083,CAV +caveolin-1,UP,Q03135,CAV1_HUMAN +CBF3 complex,FPLX,000084,CBF3 +CBF3,FPLX,000084,CBF3 +Cbl,UP,P22681,CBL_HUMAN +Cbl-b,UP,Q13191,CBLB_HUMAN +CBP,UP,Q92793,CBP_HUMAN +Cby,UP,Q9Y3M2,CBY1_HUMAN +CCAAT/enhancer binding protein,FPLX,000097,CEBP +CCN2,UP,P29279,CTGF_HUMAN +CCND1,UP,P24385,CCND1_HUMAN +CCT complex,FPLX,000085,CCT_complex +CCT,FPLX,000085,CCT_complex +Cd,PUBCHEM,23973, +Cd,CHEBI,CHEBI:22977,cadmium atom +CD16,FPLX,000086,CD16 +CD24,UP,P25063,CD24_HUMAN +CD28,UP,P10747,CD28_HUMAN +CD3,FPLX,000087,CD3 +CD32,FPLX,000088,CD32 +CD4,UP,P01730,CD4_HUMAN +CD44,UP,P16070,CD44_HUMAN +CD64,FPLX,000089,CD64 +CD8,FPLX,000090,CD8 +CD95,UP,P25445,TNR6_HUMAN +Cdc20,UP,Q12834,CDC20_HUMAN +CDC25 family,FPLX,000091,CDC25 +Cdc25 phosphatases,FPLX,000091,CDC25 +CDC25,FPLX,000091,CDC25 +Cdc25,FPLX,000091,CDC25 +CDC42,UP,P60953,CDC42_HUMAN +Cdc42,UP,P60953,CDC42_HUMAN +Cdc6,UP,Q99741,CDC6_HUMAN +CDDP,CHEBI,CHEBI:27899,cisplatin +CDDP,PUBCHEM,441203, +CDK,FPLX,000092,CDK +Cdk,FPLX,000092,CDK +CDK1,UP,P06493,CDK1_HUMAN +Cdk1,UP,P06493,CDK1_HUMAN +CDK2,UP,P24941,CDK2_HUMAN +Cdk2,UP,P24941,CDK2_HUMAN +cdk2,UP,P24941,CDK2_HUMAN +CDK4,UP,P11802,CDK4_HUMAN +Cdk4,UP,P11802,CDK4_HUMAN +CDK6,UP,Q00534,CDK6_HUMAN +CDK8,UP,P49336,CDK8_HUMAN +CDK9,UP,P50750,CDK9_HUMAN +CDKN,FPLX,000094,CDKN +CDKN1,FPLX,000095,CDKN1 +CDKN1A,UP,P38936,CDN1A_HUMAN +CDKN2,FPLX,000096,CDKN2 +CDKs,FPLX,000092,CDK +celecoxib,PUBCHEM,2662, +celecoxib,CHEBI,CHEBI:41423,celecoxib +cell adhesion,GO,GO:0007155,cell adhesion +cell adhesion,MESH,D002448,Cell Adhesion +cell cycle,GO,GO:0007049,cell cycle +cell cycle,MESH,D002453,Cell Cycle +cell death,GO,GO:0008219,cell death +cell death,MESH,D016923,Cell Death +cell growth,GO,GO:0016049,cell growth +cell growth,MESH,D048708,Cell Growth Processes +cell migration,GO,GO:0016477,cell migration +cell migration,MESH,D002465,Cell Movement +cell migration,NCIT,C26169, +cell motility,GO,GO:0016477,cell migration +cell motility,MESH,D002465,Cell Movement +cell motility,NCIT,C16404, +cell motility,GO,GO:0048870,cell motility +cell proliferation,GO,GO:0008283,cell population proliferation +cell proliferation,MESH,D049109,Cell Proliferation +cell survival,MESH,D002470,Cell Survival +cell viability,MESH,D002470,Cell Survival +cellular senescence,GO,GO:0090398,cellular senescence +cellular senescence,MESH,D016922,Cellular Senescence +ceramide,CHEBI,CHEBI:17761,ceramide +cetuximab,CHEMBL,1201577, +CFM-4,PUBCHEM,2871439, +chaperonin containing TCP-1,FPLX,000085,CCT_complex +chaperonin,FPLX,000085,CCT_complex +chaperonin-containing t-complex polypeptide 1,FPLX,000085,CCT_complex +chaperonin-containing TCP1 complex,FPLX,000085,CCT_complex +checkpoint kinase,FPLX,000098,CHEK +chemoattractant receptor,FPLX,000100,Chemokine_receptor +chemokine,FPLX,000099,Chemokine +chemokines,FPLX,000099,Chemokine +CHIP,UP,Q9UNE7,CHIP_HUMAN +CHK1,UP,O14757,CHK1_HUMAN +Chk1,UP,O14757,CHK1_HUMAN +CHK2,UP,O96017,CHK2_HUMAN +Chk2,UP,O96017,CHK2_HUMAN +cholesterol,CHEBI,CHEBI:16113,cholesterol +cholesterol,PUBCHEM,5997, +choline esterase,FPLX,000101,Cholinesterase +cholinesterase,FPLX,000101,Cholinesterase +CHOP,UP,P35638,DDIT3_HUMAN +CIP1,UP,P38936,CDN1A_HUMAN +CIP2A,UP,Q8TCG1,CIP2A_HUMAN +Cisplatin,CHEBI,CHEBI:27899,cisplatin +Cisplatin,PUBCHEM,441203, +cisplatin,CHEBI,CHEBI:27899,cisplatin +cisplatin,PUBCHEM,441203, +CK2,FPLX,000104,CK2 +CKI,FPLX,000094,CDKN +Clade B serpin,FPLX,000431,SERPINB +clade B serpins,FPLX,000431,SERPINB +Class 1 NF-kappaBs,FPLX,000312,NFkappaB_1 +class 1 NF-kappaBs,FPLX,000312,NFkappaB_1 +Class 1 NF-κBs,FPLX,000312,NFkappaB_1 +class 1 NF-κBs,FPLX,000312,NFkappaB_1 +Class 2 NF-kappaBs,FPLX,000313,NFkappaB_2 +class 2 NF-kappaBs,FPLX,000313,NFkappaB_2 +Class 2 NF-κBs,FPLX,000313,NFkappaB_2 +class 2 NF-κBs,FPLX,000313,NFkappaB_2 +Class C GPCR,FPLX,000187,GPCR +Class I HDACs,FPLX,000221,HDAC_I +class I HDACs,FPLX,000221,HDAC_I +class I histone deacetylases,FPLX,000221,HDAC_I +Class I NF-kappaBs,FPLX,000312,NFkappaB_1 +class I NF-kappaBs,FPLX,000312,NFkappaB_1 +Class I NF-κBs,FPLX,000312,NFkappaB_1 +class I NF-κBs,FPLX,000312,NFkappaB_1 +class II HDACs,FPLX,000222,HDAC_II +class II histone deacetylases,FPLX,000222,HDAC_II +Class II NF-kappaBs,FPLX,000313,NFkappaB_2 +class II NF-kappaBs,FPLX,000313,NFkappaB_2 +Class II NF-κBs,FPLX,000313,NFkappaB_2 +class II NF-κBs,FPLX,000313,NFkappaB_2 +Class III HDACs,FPLX,000223,HDAC_III +class III HDACs,FPLX,000223,HDAC_III +class III histone deacetylases,FPLX,000223,HDAC_III +Class IV HDACs,FPLX,000224,HDAC_IV +class IV HDACs,FPLX,000224,HDAC_IV +class IV histone deacetylases,FPLX,000224,HDAC_IV +clathrin coat,FPLX,000105,Clathrin +clathrin,FPLX,000105,Clathrin +cleaved PARP,UP,P09874,PARP1_HUMAN +cMet receptor,UP,P08581,MET_HUMAN +CNKSR,FPLX,000106,CNKSR +CO 2,CHEBI,CHEBI:16526,carbon dioxide +CO 2,PUBCHEM,280, +CO,CHEBI,CHEBI:17245,carbon monoxide +CO,PUBCHEM,281, +cocaine,PUBCHEM,446220, +cocaine,CHEBI,CHEBI:27958,cocaine +cofilin,FPLX,000107,Cofilin +cohesin complex,FPLX,000108,Cohesin +cohesin,FPLX,000108,Cohesin +Col4,FPLX,000110,COL4 +COLGALT,FPLX,000112,COLGALT +ColIV,FPLX,000110,COL4 +Collagen beta(1-O)galactosyltransferase,FPLX,000112,COLGALT +Collagen beta(1-O)galactosyltransferases,FPLX,000112,COLGALT +collagen beta(1-O)galactosyltransferase,FPLX,000112,COLGALT +collagen beta(1-O)galactosyltransferases,FPLX,000112,COLGALT +collagen IV,FPLX,000110,COL4 +collagen type I,FPLX,000109,COL1 +Collagen Type IV,FPLX,000110,COL4 +collagen type IV,FPLX,000110,COL4 +collagen type V,FPLX,000111,COL5 +collagen,MESH,D003094,Collagen +collagen,CHEBI,CHEBI:3815,Collagen +complex II,FPLX,000502,ETC_complex_II +complex III,FPLX,000503,ETC_complex_III +Complex IV,FPLX,000113,COX +connector enhancer of kinase suppressor of ras,FPLX,000106,CNKSR +copper,CHEBI,CHEBI:29036,copper(2+) +copper,PUBCHEM,27099, +cortactin,IP,IPR015503, +cortactin,UP,Q14247,SRC8_HUMAN +COX-2,UP,P35354,PGH2_HUMAN +Cox4,FPLX,000114,COX4 +COX6A,FPLX,000115,COX6A +Cox6a,FPLX,000115,COX6A +Cox6b,FPLX,000116,COX6B +COX7A,FPLX,000117,COX7A +Cox7a,FPLX,000117,COX7A +Cox7b,FPLX,000118,COX7B +Cox8,FPLX,000119,COX8 +cPARP,UP,P09874,PARP1_HUMAN +cPLA2,FPLX,000366,PLA2 +CRAF,UP,P04049,RAF1_HUMAN +CREB family,FPLX,000120,CREB +CREB,FPLX,000120,CREB +CRISP,FPLX,000121,CRISP +CRISPs,FPLX,000121,CRISP +Crk,UP,P46108,CRK_HUMAN +CRSP complex,FPLX,000122,CRSP +CRSP,FPLX,000122,CRSP +CRSP/Med complex,FPLX,000122,CRSP +CsA,PUBCHEM,5284373, +CsA,CHEBI,CHEBI:4031,cyclosporin A +CSC,MESH,D014411,Neoplastic Stem Cells +CSF-1R,UP,P07333,CSF1R_HUMAN +CSNK1,FPLX,000124,CSNK1 +CSNK2,FPLX,000125,CSNK2 +CtIP,UP,Q99708,CTIP_HUMAN +cTnC,FPLX,000478,Troponin_C +cTnI,FPLX,000478,Troponin_C +cTnT,FPLX,000480,Troponin_T +cullin proteins,FPLX,000127,CUL +cullin,FPLX,000127,CUL +cullins,FPLX,000127,CUL +Curcumin,CHEBI,CHEBI:3962,curcumin +Curcumin,PUBCHEM,969516, +curcumin,CHEBI,CHEBI:3962,curcumin +curcumin,PUBCHEM,969516, +CXCL12,UP,P48061,SDF1_HUMAN +CXCL8,UP,P10145,IL8_HUMAN +CXCR2,UP,P25025,CXCR2_HUMAN +CXCR4,UP,P61073,CXCR4_HUMAN +cyclic AMP-dependent protein kinase,FPLX,000363,PKA +cyclic-AMP-dependent protein kinase,FPLX,000363,PKA +Cyclin A,FPLX,000131,Cyclin_A +cyclin A,FPLX,000131,Cyclin_A +Cyclin D,FPLX,000132,Cyclin_D +Cyclin D2,UP,P30279,CCND2_HUMAN +cyclin D2,UP,P30279,CCND2_HUMAN +cyclin dependent kinase inhibitors,FPLX,000094,CDKN +cyclin E,FPLX,000133,Cyclin_E +cyclin family,FPLX,000130,Cyclin +Cyclin,FPLX,000130,Cyclin +cyclin,FPLX,000130,Cyclin +Cyclin-A,FPLX,000131,Cyclin_A +cyclin-dependent kinase inhibitor,FPLX,000094,CDKN +cyclin-dependent protein kinase inhibitors,FPLX,000094,CDKN +cyclins,FPLX,000130,Cyclin +cyclophilin,FPLX,000134,Cyclophilin +cyclophilins,FPLX,000134,Cyclophilin +CYLD,UP,Q9NQC7,CYLD_HUMAN +cypermethrin,CHEBI,CHEBI:4042,cypermethrin +cypermethrin,PUBCHEM,2912, +cysteine rich secretory proteins,FPLX,000121,CRISP +cysteine-rich secretory proteins,FPLX,000121,CRISP +cytochrome bc1 complex,FPLX,000503,ETC_complex_III +Cytochrome c oxidase subunit 6a,FPLX,000115,COX6A +cytochrome c oxidase subunit VIII,FPLX,000119,COX8 +cytochrome c oxidase,FPLX,000113,COX +cytochrome C,UP,P99999,CYC_HUMAN +cytochrome c,UP,P99999,CYC_HUMAN +cytokine production,GO,GO:0001816,cytokine production +cytoplasmic dynein,FPLX,000135,Cytoplasmic_dynein +cytosolic phospholipase A(2),FPLX,000366,PLA2 +cytosolic phospholipase A2,FPLX,000366,PLA2 +cytosolic PLA2,FPLX,000366,PLA2 +DA,PUBCHEM,681, +DA,CHEBI,CHEBI:18243,dopamine +dabrafenib,PUBCHEM,44462760, +dabrafenib,CHEBI,CHEBI:75045,dabrafenib +DAG kinase,FPLX,000140,DGK +DAG,PUBCHEM,6026790, +DAG,CHEBI,CHEBI:85682,diacylglycerol 30:1 +damage,MESH,D004249,DNA Damage +Danusertib,PUBCHEM,11442891, +Danusertib,CHEMBL,CHEMBL402548, +Danusertib,CHEBI,CHEBI:94490,"N-[5-[(2R)-2-methoxy-1-oxo-2-phenylethyl]-4,6-dihydro-1H-pyrrolo[3,4-c]pyrazol-3-yl]-4-(4-methyl-1-piperazinyl)benzamide" +danusertib,PUBCHEM,11442891, +danusertib,CHEMBL,CHEMBL402548, +danusertib,CHEBI,CHEBI:94490,"N-[5-[(2R)-2-methoxy-1-oxo-2-phenylethyl]-4,6-dihydro-1H-pyrrolo[3,4-c]pyrazol-3-yl]-4-(4-methyl-1-piperazinyl)benzamide" +dapagliflozin,CHEBI,CHEBI:85078,dapagliflozin +dapagliflozin,PUBCHEM,9887712, +dasatinib,CHEBI,CHEBI:49375,dasatinib (anhydrous) +dasatinib,PUBCHEM,3062316, +DDR,GO,GO:0042769,"DNA damage response, detection of DNA damage" +death receptor,FPLX,000137,Death_receptor +death receptors,FPLX,000137,Death_receptor +death,GO,GO:0008219,cell death +death,MESH,D016923,Cell Death +delta-tubulin,HGNC,16811,TUBD1 +desmoglein,FPLX,000138,Desmoglein +desmogleins,FPLX,000138,Desmoglein +dexamethasone,PUBCHEM,5743, +dexamethasone,CHEBI,CHEBI:41879,dexamethasone +DGC,FPLX,000139,DGC +DGK,FPLX,000140,DGK +DHA,CHEBI,CHEBI:207229,dihydroartemisinin +DHA,PUBCHEM,6918483, +DHT,PUBCHEM,11302, +DHT,CHEBI,CHEBI:2150,5beta-dihydrotestosterone +diacyl glycerol kinase,FPLX,000140,DGK +diacylglycerol kinase,FPLX,000140,DGK +differentiation,GO,GO:0030154,cell differentiation +differentiation,MESH,D002454,Cell Differentiation +diosmetin,CHEBI,CHEBI:4630,diosmetin +diosmetin,PUBCHEM,5281612, +discoidin domain receptor family,FPLX,000136,DDR +discoidin domain receptors,FPLX,000136,DDR +discoidin domain-containing receptor,FPLX,000136,DDR +dishevelled,FPLX,000145,DVL +DNA polymerase delta,FPLX,000141,DNA_polymerase_delta +DNA polymerase δ,FPLX,000141,DNA_polymerase_delta +DNA repair,GO,GO:0006281,DNA repair +DNA repair,MESH,D004260,DNA Repair +DNA replication factor C complex,FPLX,000411,RFC +DNA replication factor C,FPLX,000411,RFC +DNA-PKcs,UP,P78527,PRKDC_HUMAN +DNA-Pkcs,UP,P78527,PRKDC_HUMAN +docetaxel,PUBCHEM,148124, +docetaxel,CHEBI,CHEBI:4672,docetaxel anhydrous +Dok1,UP,Q99704,DOK1_HUMAN +Dok2,UP,O60496,DOK2_HUMAN +dopamine receptor,FPLX,000143,DRD +dopamine receptors,FPLX,000143,DRD +dopamine,PUBCHEM,681, +dopamine,CHEBI,CHEBI:18243,dopamine +doxorubicin,CHEBI,CHEBI:28748,doxorubicin +doxorubicin,PUBCHEM,31703, +doxycycline,PUBCHEM,54671203, +doxycycline,CHEBI,CHEBI:50845,doxycycline +DP complex,FPLX,000464,TFDP +DR4,UP,O00220,TR10A_HUMAN +DR5,UP,O14763,TR10B_HUMAN +DSB,MESH,D053903,"DNA Breaks, Double-Stranded" +DUSP,FPLX,000144,DUSP +DUSP1,UP,P28562,DUS1_HUMAN +Dvl,FPLX,000145,DVL +dynamin family,FPLX,000142,DNM +dynamin,FPLX,000142,DNM +dystrophin glycoprotein complex,FPLX,000139,DGC +dystrophin glycoprotein,FPLX,000139,DGC +dystrophin-associated glycoprotein complex,FPLX,000139,DGC +dystrophin-glycoprotein complex,FPLX,000139,DGC +E-cadherin,UP,P12830,CADH1_HUMAN +E2 enzyme,FPLX,000489,UBE2 +E2 ubiquitin-conjugating enzyme,FPLX,000489,UBE2 +E2,FPLX,000489,UBE2 +E2,UP,P27958,POLG_HCVH +E2F,FPLX,000147,E2F +E2F-1,UP,Q01094,E2F1_HUMAN +E2F1,UP,Q01094,E2F1_HUMAN +E3 ubiquitin ligase,FPLX,000148,E3_Ub_ligase +E3,FPLX,000148,E3_Ub_ligase +E6,UP,P03126,VE6_HPV16 +E7,UP,P03129,VE7_HPV16 +early growth response proteins,FPLX,000151,EGR +EBNA3C,UP,I1YP21, +ECM,GO,GO:0031012,extracellular matrix +Ect2,UP,Q9H8V3,ECT2_HUMAN +EGCG,PUBCHEM,65064, +EGCG,CHEBI,CHEBI:4806,(-)-epigallocatechin 3-gallate +EGF receptor,UP,P00533,EGFR_HUMAN +EGF,UP,P01133,EGF_HUMAN +EGFR ligand,FPLX,000150,EGFR_ligand +EGFR ligands,FPLX,000150,EGFR_ligand +EGFR,UP,P00533,EGFR_HUMAN +EGFRvIII,UP,P00533,EGFR_HUMAN +EGR,FPLX,000151,EGR +eIF2alpha,UP,P05198,IF2A_HUMAN +EIF2B,FPLX,000152,EIF2B +eIF2B,FPLX,000152,EIF2B +eIF2α,UP,P05198,IF2A_HUMAN +eIF4A,FPLX,000153,EIF4A +eIF4E,UP,P06730,IF4E_HUMAN +eIF4G,FPLX,000155,EIF4G +elastase,FPLX,000156,ELA +Elk-1,UP,P19419,ELK1_HUMAN +Elk1,UP,P19419,ELK1_HUMAN +ELMO1,UP,Q92556,ELMO1_HUMAN +ELR (+) CXC chemokines,FPLX,000129,CXCL_ELR_positive +ELR (-) CXC chemokines,FPLX,000128,CXCL_ELR_negative +ELR-negative CXC chemokine,FPLX,000128,CXCL_ELR_negative +ELR-negative CXC family,FPLX,000128,CXCL_ELR_negative +ELR-positive CXC chemokine,FPLX,000129,CXCL_ELR_positive +ELR-positive CXC family,FPLX,000129,CXCL_ELR_positive +embelin,CHEBI,CHEBI:4778,embelin +embelin,PUBCHEM,3218, +emodin,PUBCHEM,3220, +emodin,CHEBI,CHEBI:42223,emodin +EMT,GO,GO:0001837,epithelial to mesenchymal transition +EMT,MESH,D058750,Epithelial-Mesenchymal Transition +endocytosis,GO,GO:0006897,endocytosis +endocytosis,MESH,D004705,Endocytosis +endothelin,FPLX,000149,EDN +endothelins,FPLX,000149,EDN +enolase,FPLX,000157,ENO +eNOS,UP,P29474,NOS3_HUMAN +Env,UP,U3LIR9, +Eph receptor,FPLX,000158,Ephrin_receptor +Eph receptors,FPLX,000158,Ephrin_receptor +EphA2,UP,P29317,EPHA2_HUMAN +EphB1,UP,P54762,EPHB1_HUMAN +ephrin receptor,FPLX,000158,Ephrin_receptor +epidermal growth factor receptor,UP,P00533,EGFR_HUMAN +epidermal growth factor,UP,P01133,EGF_HUMAN +Eps8,UP,Q12929,EPS8_HUMAN +epsilon-tubulin,HGNC,20775,TUBE1 +epsin,FPLX,000159,EPN +epsins,FPLX,000159,EPN +ER,FPLX,000162,ESR +ER,MESH,D004721,Endoplasmic Reticulum +ER,GO,GO:0005783,endoplasmic reticulum +ER,UP,P03372,ESR1_HUMAN +ERalpha,UP,P03372,ESR1_HUMAN +ErbB,FPLX,000160,ERBB +ERBB2,UP,P04626,ERBB2_HUMAN +ErbB2,UP,P04626,ERBB2_HUMAN +ErbB3,UP,P21860,ERBB3_HUMAN +ERK 1/2,FPLX,000161,ERK +ERK inhibitors,CHEBI,CHEBI:79091,EC 2.7.11.24 (mitogen-activated protein kinase) inhibitor +ERK MAPK,FPLX,000161,ERK +ERK mitogen-activated protein kinase,FPLX,000161,ERK +ERK,FPLX,000161,ERK +Erk,FPLX,000161,ERK +ERK-1/2,FPLX,000161,ERK +ERK1,UP,P27361,MK03_HUMAN +Erk1,UP,P27361,MK03_HUMAN +ERK1/2 MAPK,FPLX,000161,ERK +ERK1/2,FPLX,000161,ERK +Erk1/2,FPLX,000161,ERK +ERK2,UP,P28482,MK01_HUMAN +ERK5,UP,Q13164,MK07_HUMAN +ERKs,FPLX,000161,ERK +erlotinib,PUBCHEM,176870, +erlotinib,CHEBI,CHEBI:114785,erlotinib +ERα,UP,P03372,ESR1_HUMAN +ESR,FPLX,000162,ESR +estradiol,CHEBI,CHEBI:23965,estradiol +estradiol,PUBCHEM,9811784, +estrogen receptor,UP,P03372,ESR1_HUMAN +estrogen,CHEBI,CHEBI:50114,estrogen +ET-1,UP,P05305,EDN1_HUMAN +ethanol,PUBCHEM,702, +ethanol,CHEBI,CHEBI:16236,ethanol +ethanol,HMDB,HMDB00108, +etoposide,PUBCHEM,36462, +etoposide,CHEBI,CHEBI:4911,etoposide +ETS,FPLX,000163,ETS +ETS-1,UP,P14921,ETS1_HUMAN +Ets-1,UP,P14921,ETS1_HUMAN +ETS1,UP,P14921,ETS1_HUMAN +eukaryotic initiation factor 4E,UP,P06730,IF4E_HUMAN +eukaryotic initiation factor-4A,FPLX,000153,EIF4A +Everolimus,PUBCHEM,6442177, +Everolimus,CHEBI,CHEBI:68478,everolimus +everolimus,PUBCHEM,6442177, +everolimus,CHEBI,CHEBI:68478,everolimus +EXOC,FPLX,000164,EXOC +exocyst complex,FPLX,000164,EXOC +exocyst,FPLX,000164,EXOC +Exostosin glycosyltransferase family,FPLX,000165,EXT +exostosin glycosyltransferase family,FPLX,000165,EXT +EXT,FPLX,000165,EXT +Extracellular Signal Regulated Kinase,FPLX,000161,ERK +extracellular signal-regulated kinase,FPLX,000161,ERK +EZH2,UP,Q15910,EZH2_HUMAN +ezrin,UP,P15311,EZRI_HUMAN +F-actin,FPLX,000178,F_actin +FADD,UP,Q13158,FADD_HUMAN +FAK,UP,Q05397,FAK1_HUMAN +FAM83B,UP,Q5T0W9,FA83B_HUMAN +FANC proteins,FPLX,000166,FANC +FANC,FPLX,000166,FANC +FANCJ,UP,Q9BX63,FANCJ_HUMAN +farnesyltransferase,FPLX,000172,FNT +Fas,UP,P25445,TNR6_HUMAN +FasL,UP,P48023,TNFL6_HUMAN +FGF,FPLX,000167,FGF +FGF-2,UP,P09038,FGF2_HUMAN +FGF2,UP,P09038,FGF2_HUMAN +FGFR,FPLX,000168,FGFR +FGFR1,UP,P11362,FGFR1_HUMAN +FGFR2,UP,P21802,FGFR2_HUMAN +FGFR3,UP,P22607,FGFR3_HUMAN +FGFR4,UP,P22455,FGFR4_HUMAN +fibrinogen,FPLX,000169,Fibrinogen +fibronectin,UP,P02751,FINC_HUMAN +fisetin,CHEBI,CHEBI:42567,fisetin +fisetin,PUBCHEM,5281614, +Flip,UP,O15519,CFLAR_HUMAN +flotillin,FPLX,000170,FLOT +FLRT family,FPLX,000171,FLRT +Flrt family,FPLX,000171,FLRT +FLRT proteins,FPLX,000171,FLRT +FLT3,UP,P36888,FLT3_HUMAN +FN,UP,P02751,FINC_HUMAN +follicle-stimulating hormone,FPLX,000175,FSH +FOS,FPLX,000173,FOS_family +Fos,FPLX,000173,FOS_family +FOXM1,UP,Q08050,FOXM1_HUMAN +FOXO,FPLX,000174,FOXO +FoxO,FPLX,000174,FOXO +FOXO1,UP,Q12778,FOXO1_HUMAN +FoxO1,UP,Q12778,FOXO1_HUMAN +FOXO3,UP,O43524,FOXO3_HUMAN +FOXO3a,UP,O43524,FOXO3_HUMAN +FoxO3a,UP,O43524,FOXO3_HUMAN +FRK,UP,P42685,FRK_HUMAN +fructose-bisphosphate aldolase,FPLX,000025,ALDO +FSH,FPLX,000175,FSH +FTase,FPLX,000172,FNT +FTS,PUBCHEM,5469318, +Fucosyltransferase,FPLX,000176,FUT +Fucosyltransferases,FPLX,000176,FUT +fucosyltransferase,FPLX,000176,FUT +fucosyltransferases,FPLX,000176,FUT +FUT,FPLX,000176,FUT +Fyn,UP,P06241,FYN_HUMAN +Fz,FPLX,000177,FZD +FZD,FPLX,000177,FZD +G 1,GO,GO:0051318,G1 phase +G 1,MESH,D016193,G1 Phase +G 2,MESH,D016195,G2 Phase +G alphai,FPLX,000213,G_i_alpha +G alphaq,FPLX,000216,G_q_alpha +G alphaS,FPLX,000218,G_s_alpha +G protein beta,FPLX,000210,G_beta +G protein gamma subunit,FPLX,000211,G_gamma +G protein gamma,FPLX,000211,G_gamma +G protein Gs,FPLX,000217,G_s +G protein γ subunit,FPLX,000211,G_gamma +G protein β,FPLX,000210,G_beta +G protein γ,FPLX,000211,G_gamma +G protein(s),FPLX,000217,G_s +G protein,FPLX,000214,G_protein +G protein-coupled receptor kinases,FPLX,000192,GRK +G proteins,FPLX,000214,G_protein +G S protein,FPLX,000217,G_s +G αi,FPLX,000213,G_i_alpha +G αq,FPLX,000216,G_q_alpha +G αS,FPLX,000218,G_s_alpha +G(12),FPLX,000207,G_12 +G(q/11),FPLX,000215,G_q +G-alpha(s),FPLX,000218,G_s_alpha +G-AlphaS,FPLX,000218,G_s_alpha +G-protein alpha-12,FPLX,000208,G_12_alpha +G-Protein alpha-i,FPLX,000213,G_i_alpha +G-Protein alpha-q,FPLX,000216,G_q_alpha +G-Protein alpha-s,FPLX,000218,G_s_alpha +G-protein beta,FPLX,000210,G_beta +G-protein β,FPLX,000210,G_beta +G-protein α-12,FPLX,000208,G_12_alpha +G-Protein α-i,FPLX,000213,G_i_alpha +G-Protein α-q,FPLX,000216,G_q_alpha +G-Protein α-s,FPLX,000218,G_s_alpha +G-α(s),FPLX,000218,G_s_alpha +G-αS,FPLX,000218,G_s_alpha +G12 family,FPLX,000207,G_12 +G12 proteins,FPLX,000207,G_12 +G12,FPLX,000207,G_12 +GA,PUBCHEM,370, +GA,CHEBI,CHEBI:30778,gallic acid +Ga12,FPLX,000208,G_12_alpha +Gab1,UP,Q13480,GAB1_HUMAN +Gab2,UP,Q9UQC2,GAB2_HUMAN +GABA receptor,FPLX,000179,GABR +GABA receptors,FPLX,000179,GABR +GABA-A receptor,FPLX,000179,GABR +GALNT,FPLX,000180,GALNT +Galpha12,FPLX,000208,G_12_alpha +Galphai,FPLX,000213,G_i_alpha +Galphaq,FPLX,000216,G_q_alpha +GalphaS,FPLX,000218,G_s_alpha +gamma secretase,FPLX,000181,Gamma_secretase +Gamma tubulin,FPLX,000485,TUBG +gamma tubulin,FPLX,000485,TUBG +gamma-aminobutyric-acid A receptor,FPLX,000179,GABR +gamma-secretase,FPLX,000181,Gamma_secretase +gamma-tubulin,FPLX,000485,TUBG +GAP,FPLX,000182,GAP +Gas6 receptors,FPLX,000183,GAS6_receptor +gastrin,UP,P01350,GAST_HUMAN +GATA family,FPLX,000184,GATA +GATA,FPLX,000184,GATA +Gbeta,FPLX,000210,G_beta +GCNT,FPLX,000185,GCNT +GDF15,UP,Q99988,GDF15_HUMAN +GDP,HMDB,HMDB01201, +GDP,PUBCHEM,135398619, +GDP,CHEBI,CHEBI:17552,GDP +GEF,FPLX,000186,GEF +GEF-H1,UP,Q92974,ARHG2_HUMAN +gefitinib,PUBCHEM,123631, +gefitinib,CHEBI,CHEBI:49668,gefitinib +GEFs,FPLX,000186,GEF +general transcription factor II E,FPLX,000196,GTF2E +general transcription factor II F,FPLX,000197,GTF2F +genistein,CHEBI,CHEBI:28088,genistein +genistein,PUBCHEM,5280961, +Gi alpha subunit,FPLX,000213,G_i_alpha +Gi alpha,FPLX,000213,G_i_alpha +Gi protein,FPLX,000212,G_i +Gi α subunit,FPLX,000213,G_i_alpha +Gi α,FPLX,000213,G_i_alpha +Gi,FPLX,000212,G_i +GII PLA2,FPLX,000367,PLA2G2 +GIIPLA2,FPLX,000367,PLA2G2 +gIV-PLA(2),FPLX,000368,PLA2G4 +glucose transporter,FPLX,000434,SLC2A +glucose transporters,FPLX,000434,SLC2A +Glucose,HMDB,HMDB00122, +glucose,HMDB,HMDB00122, +GLUT,FPLX,000434,SLC2A +glutamate metabotropic receptors,FPLX,000193,GRM +glutathione peroxidase,FPLX,000190,GPX +glutathione S-transferase,FPLX,000195,GST +glutathione,PUBCHEM,124886, +glutathione,CHEBI,CHEBI:16856,glutathione +glutathione,HMDB,HMDB00125, +Glycogen phosphorylase,FPLX,000396,PYG +Glycogen phosphorylases,FPLX,000396,PYG +glycogen phosphorylase,FPLX,000396,PYG +glycogen phosphorylases,FPLX,000396,PYG +glycogen synthase,FPLX,000206,GYS +glycolysis,GO,GO:0006096,glycolytic process +glycolysis,MESH,D006019,Glycolysis +glycoprotein Ib-V-IX complex,FPLX,000188,GPIb_IX_V +Glycoprotein Ib-V-IX,FPLX,000188,GPIb_IX_V +Glycoprotein Ib/V/IX,FPLX,000188,GPIb_IX_V +glycosylphosphatidylinositol transamidase complex,FPLX,000189,GPIT +Glycosyltransferase family 2,FPLX,000199,GTF_family_2 +glycosyltransferase family 2,FPLX,000199,GTF_family_2 +Glycosyltransferase family 29,FPLX,000202,GTF_family_29 +glycosyltransferase family 29,FPLX,000202,GTF_family_29 +Glycosyltransferase family 6,FPLX,000200,GTF_family_6 +glycosyltransferase family 6,FPLX,000200,GTF_family_6 +Glycosyltransferase family 8,FPLX,000201,GTF_family_8 +glycosyltransferase family 8,FPLX,000201,GTF_family_8 +Glycosyltransferase family 90,FPLX,000203,GTF_family_90 +glycosyltransferase family 90,FPLX,000203,GTF_family_90 +gp120,UP,P04578,ENV_HV1H2 +gp47 phox,UP,P14598,NCF1_HUMAN +gp91 phox,UP,P04839,CY24B_HUMAN +GPCR kinases,FPLX,000192,GRK +GPCR,FPLX,000187,GPCR +GPCRs,FPLX,000187,GPCR +GPI transamidase complex,FPLX,000189,GPIT +GPIb-IX-V complex,FPLX,000188,GPIb_IX_V +GPIb-IX-V,FPLX,000188,GPIb_IX_V +GpIb-V-IX,FPLX,000188,GPIb_IX_V +GPIT complex,FPLX,000189,GPIT +GPIT,FPLX,000189,GPIT +Gq alpha subunit,FPLX,000216,G_q_alpha +Gq alpha,FPLX,000216,G_q_alpha +Gq α subunit,FPLX,000216,G_q_alpha +Gq α,FPLX,000216,G_q_alpha +Gq/11,FPLX,000215,G_q +GR,UP,P00390,GSHR_HUMAN +GRB2,UP,P62993,GRB2_HUMAN +Grb2,UP,P62993,GRB2_HUMAN +GRK,FPLX,000192,GRK +GRKs,FPLX,000192,GRK +group IV-PLA(2),FPLX,000368,PLA2G4 +GRP78,UP,P11021,BIP_HUMAN +Gs alpha subunit,FPLX,000218,G_s_alpha +Gs alpha,FPLX,000218,G_s_alpha +Gs family,FPLX,000217,G_s +Gs protein,FPLX,000217,G_s +Gs α subunit,FPLX,000218,G_s_alpha +Gs α,FPLX,000218,G_s_alpha +GSH,PUBCHEM,124886, +GSH,CHEBI,CHEBI:16856,glutathione +GSH,HMDB,HMDB00125, +GSK-3,FPLX,000194,GSK3 +GSK-3beta,UP,P49841,GSK3B_HUMAN +GSK-3β,UP,P49841,GSK3B_HUMAN +GSK3,FPLX,000194,GSK3 +GSK3beta,UP,P49841,GSK3B_HUMAN +GSK3β,UP,P49841,GSK3B_HUMAN +GST,FPLX,000195,GST +GSTs,FPLX,000195,GST +GTP,HMDB,HMDB01273, +GTP,CHEBI,CHEBI:15996,GTP +GTP,PUBCHEM,135398633, +GTPase,FPLX,000204,GTPase +GTPase-activating proteins,FPLX,000182,GAP +guanine,PUBCHEM,135398634, +guanine,CHEBI,CHEBI:16235,guanine +guanylate cyclase,FPLX,000205,GUCY +guanylyl cyclase,FPLX,000205,GUCY +G_alpha,FPLX,000209,G_alpha +G_α,FPLX,000209,G_alpha +Gβ,FPLX,000210,G_beta +Gα12,FPLX,000208,G_12_alpha +Gαi,FPLX,000213,G_i_alpha +Gαq,FPLX,000216,G_q_alpha +GαS,FPLX,000218,G_s_alpha +H-Ras,UP,P01112,RASH_HUMAN +H/R,MESH,D015687,Cell Hypoxia +H2AX,UP,P16104,H2AX_HUMAN +H2B,FPLX,000236,Histone_H2B +H3,FPLX,000237,Histone_H3 +h9-1-1 complex,FPLX,000001,9_1_1 +haem oxygenase,FPLX,000240,HMOX +hAxin,FPLX,000062,AXIN +HB-EGF,UP,Q99075,HBEGF_HUMAN +HBx,UP,Q157B2, +hCG,FPLX,000219,hCG +HDAC inhibitor,CHEBI,CHEBI:61115,EC 3.5.1.98 (histone deacetylase) inhibitor +HDAC,FPLX,000220,HDAC +HDAC1,UP,Q13547,HDAC1_HUMAN +HDAC2,UP,Q92769,HDAC2_HUMAN +HDAC3,UP,O15379,HDAC3_HUMAN +HDACi,CHEBI,CHEBI:61115,EC 3.5.1.98 (histone deacetylase) inhibitor +HDL,FPLX,000225,HDL +HDM2,UP,Q00987,MDM2_HUMAN +Heat Shock Protein 70,FPLX,000244,HSPA +heat shock protein family B,FPLX,000245,HSPB +Hedgehog family,FPLX,000226,Hedgehog +hedgehog protein,FPLX,000226,Hedgehog +hedgehog signaling proteins,FPLX,000226,Hedgehog +Hedgehog,FPLX,000226,Hedgehog +heme oxygenase,FPLX,000240,HMOX +hemoglobin,FPLX,000227,Hemoglobin +HER-2,UP,P04626,ERBB2_HUMAN +HER2 receptor,UP,P04626,ERBB2_HUMAN +HER2,UP,P04626,ERBB2_HUMAN +HER3,UP,P21860,ERBB3_HUMAN +Hes gene family,FPLX,000228,HES +Hes genes,FPLX,000228,HES +HES,FPLX,000228,HES +Hes,FPLX,000228,HES +HG,HMDB,HMDB00122, +HGF,UP,P14210,HGF_HUMAN +Hic-5,UP,O43294,TGFI1_HUMAN +HIF,FPLX,000229,HIF +HIF-1,FPLX,000230,HIF1 +HIF-1alpha protein,UP,Q16665,HIF1A_HUMAN +HIF-1alpha,UP,Q16665,HIF1A_HUMAN +HIF-1α protein,UP,Q16665,HIF1A_HUMAN +HIF-1α,UP,Q16665,HIF1A_HUMAN +HIF1alpha protein,UP,Q16665,HIF1A_HUMAN +HIF1alpha,UP,Q16665,HIF1A_HUMAN +HIF1α protein,UP,Q16665,HIF1A_HUMAN +HIF1α,UP,Q16665,HIF1A_HUMAN +HIFalpha,FPLX,000231,HIF_alpha +Hifalpha,FPLX,000231,HIF_alpha +HIFbeta,FPLX,000232,HIF_beta +Hifbeta,FPLX,000232,HIF_beta +HIFs,FPLX,000229,HIF +HIFα,FPLX,000231,HIF_alpha +Hifα,FPLX,000231,HIF_alpha +HIFβ,FPLX,000232,HIF_beta +Hifβ,FPLX,000232,HIF_beta +High-density lipoproteins,FPLX,000225,HDL +HIPK2,UP,Q9H2X6,HIPK2_HUMAN +Histone 2A,FPLX,000235,Histone_H2A +histone deacetylase,FPLX,000220,HDAC +histone deacetylases,FPLX,000220,HDAC +histone H1,FPLX,000234,Histone_H1 +Histone H2A,FPLX,000235,Histone_H2A +histone H2A,FPLX,000235,Histone_H2A +histone H2B,FPLX,000236,Histone_H2B +histone H3,FPLX,000237,Histone_H3 +histone H4,FPLX,000238,Histone_H4 +Histone,FPLX,000233,Histone +histone,FPLX,000233,Histone +histone-3,FPLX,000237,Histone_H3 +histones,FPLX,000233,Histone +HLA-DR,FPLX,000239,HLA_DR +HMGB1,UP,P09429,HMGB1_HUMAN +HO-1,UP,P09601,HMOX1_HUMAN +homeodomain iroquois proteins,FPLX,000265,IRX +HOTAIR,HGNC,33510,HOTAIR +HOTAIR,NONCODE,NONHSAT028507.2, +HOTAIR,LNCRNADB,HOTAIR, +HR,GO,GO:0000725,recombinational repair +HR,MESH,D059767,Recombinational DNA Repair +HRAS,UP,P01112,RASH_HUMAN +HRASV12,UP,P01112,RASH_HUMAN +HSF1,UP,Q00613,HSF1_HUMAN +HSP20,UP,O14558,HSPB6_HUMAN +HSP27,UP,P04792,HSPB1_HUMAN +HSP70,FPLX,000244,HSPA +Hsp70,FPLX,000244,HSPA +HSP90,FPLX,000241,HSP90 +Hsp90,FPLX,000241,HSP90 +HSP90A,FPLX,000242,HSP90A +HSP90AA,FPLX,000243,HSP90AA +HSPB proteins,FPLX,000245,HSPB +HSPB,FPLX,000245,HSPB +hTERT,UP,O14746,TERT_HUMAN +HuR,HGNC,3312,ELAVL1 +HuR,UP,Q15717,ELAV1_HUMAN +hydrogen peroxide,PUBCHEM,784, +hydrogen peroxide,CHEBI,CHEBI:16240,hydrogen peroxide +hypoxia-inducible factors,FPLX,000229,HIF +I/R,MESH,D011839,"Radiation, Ionizing" +ICAM-1,UP,P05362,ICAM1_HUMAN +IER3,UP,P46695,IEX1_HUMAN +IFI16,UP,Q16666,IF16_HUMAN +IFN,FPLX,000262,Interferon +IFN-a,FPLX,000246,IFNA +IFN-alpha,FPLX,000246,IFNA +IFN-beta,FPLX,000247,IFNB +IFN-beta,UP,P01574,IFNB_HUMAN +IFN-gamma,UP,P01579,IFNG_HUMAN +IFN-α,FPLX,000246,IFNA +IFN-β,FPLX,000247,IFNB +IFN-β,UP,P01574,IFNB_HUMAN +IFN-γ,UP,P01579,IFNG_HUMAN +IFNalpha,FPLX,000246,IFNA +IFNgamma,UP,P01579,IFNG_HUMAN +IFNGR,FPLX,000263,Interferon_gamma_receptor +IFNα,FPLX,000246,IFNA +IFNγ,UP,P01579,IFNG_HUMAN +IGF-1,UP,P05019,IGF1_HUMAN +IGF-1R,UP,P08069,IGF1R_HUMAN +IGF-1Rbeta,UP,P08069,IGF1R_HUMAN +IGF-1Rβ,UP,P08069,IGF1R_HUMAN +IGF-BP,FPLX,000248,IGFBP +IGF-I,UP,P05019,IGF1_HUMAN +IGF-IR,UP,P08069,IGF1R_HUMAN +IGF1,UP,P05019,IGF1_HUMAN +IGF1R,UP,P08069,IGF1R_HUMAN +IGFBP,FPLX,000248,IGFBP +IGFBPs,FPLX,000248,IGFBP +IkappaB kinase,FPLX,000251,IKK_family +IkappaB,FPLX,000249,IKB +IkappaB-alpha,HGNC,7797,NFKBIA +IkappaBalpha,UP,P25963,IKBA_HUMAN +IKK complex,FPLX,000250,IKK_complex +IKK,FPLX,000251,IKK_family +IKKalpha,UP,O15111,IKKA_HUMAN +IKKbeta,UP,O14920,IKKB_HUMAN +IKKβ,UP,O14920,IKKB_HUMAN +IKKα,UP,O15111,IKKA_HUMAN +IL-1,FPLX,000252,IL1 +IL-10,UP,P22301,IL10_HUMAN +IL-12,FPLX,000253,IL12 +IL-15 receptor,FPLX,000254,IL15R +IL-15R,FPLX,000254,IL15R +IL-17,UP,Q16552,IL17_HUMAN +IL-18,UP,Q14116,IL18_HUMAN +IL-1beta,UP,P01584,IL1B_HUMAN +IL-1β,UP,P01584,IL1B_HUMAN +IL-2 receptor,FPLX,000255,IL2R +IL-2,UP,P60568,IL2_HUMAN +IL-2R,FPLX,000255,IL2R +IL-4,UP,P05112,IL4_HUMAN +IL-6,UP,P05231,IL6_HUMAN +IL-8,UP,P10145,IL8_HUMAN +IL1 family,FPLX,000252,IL1 +IL12,FPLX,000253,IL12 +imatinib,PUBCHEM,5291, +imatinib,LINCS,10023-103, +imatinib,CHEBI,CHEBI:45783,imatinib +immune response,GO,GO:0006955,immune response +infiltration,MESH,D009361,Neoplasm Invasiveness +inflammation,GO,GO:0006954,inflammatory response +inflammation,MESH,D007249,Inflammation +inflammatory response,GO,GO:0006954,inflammatory response +inflammatory response,MESH,0007249, +inhibin A,FPLX,000257,Inhibin_A +inhibin B,FPLX,000258,Inhibin_B +Inhibin,FPLX,000256,Inhibin +inhibin,FPLX,000256,Inhibin +inhibin-A,FPLX,000257,Inhibin_A +inhibin-a,FPLX,000257,Inhibin_A +inhibin-B,FPLX,000258,Inhibin_B +inhibin-b,FPLX,000258,Inhibin_B +initiation factor 4E binding proteins,FPLX,000154,EIF4EBP +iNOS,UP,P35228,NOS2_HUMAN +insulin family,FPLX,000259,INS +Insulin receptor family,FPLX,000260,INSR +insulin receptor family,FPLX,000260,INSR +insulin receptor substrate,FPLX,000264,IRS +insulin receptor,UP,P06213,INSR_HUMAN +insulin receptor/insulin-like growth factor receptor family,FPLX,000260,INSR +Insulin,UP,P01308,INS_HUMAN +insulin,UP,P01308,INS_HUMAN +insulin-like growth factor binding proteins,FPLX,000248,IGFBP +integrin,FPLX,000261,Integrins +integrins,FPLX,000261,Integrins +Interferon beta,FPLX,000247,IFNB +interferon beta,FPLX,000247,IFNB +interferon gamma receptor,FPLX,000263,Interferon_gamma_receptor +interferon γ receptor,FPLX,000263,Interferon_gamma_receptor +Interferon β,FPLX,000247,IFNB +interferon β,FPLX,000247,IFNB +interferon,FPLX,000262,Interferon +interferon-gamma receptor,FPLX,000263,Interferon_gamma_receptor +interferon-γ receptor,FPLX,000263,Interferon_gamma_receptor +invasion,MESH,D009361,Neoplasm Invasiveness +invasiveness,MESH,D009361,Neoplasm Invasiveness +IQGAP1,UP,P46940,IQGA1_HUMAN +IR,MESH,D011839,"Radiation, Ionizing" +IR,UP,P06213,INSR_HUMAN +IRF3,UP,Q14653,IRF3_HUMAN +iron,PUBCHEM,23925, +iron,CHEBI,CHEBI:18248,iron atom +Iroquois family,FPLX,000265,IRX +Iroquois proteins,FPLX,000265,IRX +Iroquois-class homeodomain proteins,FPLX,000265,IRX +IRS family,FPLX,000264,IRS +IRS,FPLX,000264,IRS +IRS-1,UP,P35568,IRS1_HUMAN +IRS-2,UP,Q9Y4H2,IRS2_HUMAN +IRS1,UP,P35568,IRS1_HUMAN +IRS2,UP,Q9Y4H2,IRS2_HUMAN +isoflurane,PUBCHEM,3763, +isoflurane,CHEBI,CHEBI:6015,isoflurane +IκB kinase,FPLX,000251,IKK_family +IκB,FPLX,000249,IKB +IκB-α,HGNC,7797,NFKBIA +IκBα,UP,P25963,IKBA_HUMAN +JAK,FPLX,000266,JAK +Jak,FPLX,000266,JAK +JAK2,UP,O60674,JAK2_HUMAN +JAKs,FPLX,000266,JAK +JNK MAPK,FPLX,000267,JNK +JNK,FPLX,000267,JNK +JNK1,UP,P45983,MK08_HUMAN +JNK1/2,FPLX,000267,JNK +JNKs,FPLX,000267,JNK +JQ1,PUBCHEM,46907787, +JQ1,CHEBI,CHEBI:95080,LSM-6332 +JUN,FPLX,000268,JUN_family +K-Ras,UP,P01116,RASK_HUMAN +Kainate receptors,FPLX,000269,Kainate_family +kallikrein,FPLX,000271,KLK +kallikrein-related peptidases,FPLX,000271,KLK +KARs,FPLX,000269,Kainate_family +Keap1,UP,Q14145,KEAP1_HUMAN +kinetochore centromere binding factor 3,FPLX,000084,CBF3 +kinetochore complex,FPLX,000270,Kinetochore +kinetochore,FPLX,000270,Kinetochore +kinetochores,FPLX,000270,Kinetochore +KLF5,UP,Q13887,KLF5_HUMAN +Klf5,UP,Q13887,KLF5_HUMAN +KLKs,FPLX,000271,KLK +KRAS,UP,P01116,RASK_HUMAN +Kras,UP,P01116,RASK_HUMAN +KSR,FPLX,000272,KSR +LA,CHEBI,CHEBI:30314,(R)-lipoic acid +LA,PUBCHEM,6112, +lactate,PUBCHEM,91435, +lactate,CHEBI,CHEBI:24996,lactate +laminin 332 chains,FPLX,000274,Laminin_332 +laminin 332,FPLX,000274,Laminin_332 +laminin-332 chains,FPLX,000274,Laminin_332 +laminin-332,FPLX,000274,Laminin_332 +Laminin-5,FPLX,000274,Laminin_332 +laminin-5,FPLX,000274,Laminin_332 +lapatinib,PUBCHEM,208908, +lapatinib,CHEBI,CHEBI:49603,lapatinib +LAT,UP,O43561,LAT_HUMAN +LC3,FPLX,000280,MAP1LC3 +Lck,UP,P06239,LCK_HUMAN +LDH,FPLX,000275,LDH +lead,PUBCHEM,5352425, +lead,CHEBI,CHEBI:25016,lead atom +leptin,UP,P41159,LEP_HUMAN +LFA-1 (integrin),FPLX,000261,Integrins +LH,FPLX,000276,LH +LIF,UP,P15018,LIF_HUMAN +lipopolysaccharide,CHEBI,CHEBI:16412,lipopolysaccharide +lipopolysaccharide,MESH,D008070,Lipopolysaccharides +LKB1,UP,Q15831,STK11_HUMAN +LM-1,FPLX,000273,Laminin_111 +LMP1,UP,P03230,LMP1_EBVB9 +localization,GO,GO:0051179,localization +long-chain acyl-CoA synthetase,FPLX,000008,ACSL +LPA,UP,P08519,APOA_HUMAN +LPS,CHEBI,CHEBI:16412,lipopolysaccharide +LPS,MESH,D008070,Lipopolysaccharides +LRRK2,UP,Q5S007,LRRK2_HUMAN +Luteinizing hormone,FPLX,000276,LH +luteinizing hormone,FPLX,000276,LH +luteinizing-hormone,FPLX,000276,LH +luteolin,PUBCHEM,5280445, +luteolin,CHEBI,CHEBI:15864,luteolin +MA,PUBCHEM,10836, +MA,CHEBI,CHEBI:6809,methamphetamine +MA,PUBCHEM,73659, +MA,CHEBI,CHEBI:66682,maslinic acid +MA,UP,P04591,GAG_HV1H2 +MAC,FPLX,000278,MAC +MAC-1 (integrin),FPLX,000261,Integrins +Mad2,UP,Q13257,MD2L1_HUMAN +Maf subfamily,FPLX,000279,MAF +MAF,FPLX,000279,MAF +Maf,FPLX,000279,MAF +maf,FPLX,000279,MAF +MAF,UP,O75444,MAF_HUMAN +Maf,UP,O75444,MAF_HUMAN +maf,UP,O75444,MAF_HUMAN +mammalian target of rapamycin,UP,P42345,MTOR_HUMAN +mangiferin,CHEBI,CHEBI:6682,mangiferin +mangiferin,PUBCHEM,5281647, +MAP kinase,FPLX,000283,MAPK +MAP kinases,FPLX,000283,MAPK +MAP2K1,UP,Q02750,MP2K1_HUMAN +MAP2K2,UP,P36507,MP2K2_HUMAN +MAP3K,FPLX,000282,MAP3K +MAP3K2,UP,Q9Y2U5,M3K2_HUMAN +MAPK kinase kinase,FPLX,000282,MAP3K +MAPK kinase,FPLX,000281,MAP2K +MAPK p38,FPLX,000326,p38 +MAPK,FPLX,000161,ERK +MAPK1,UP,P28482,MK01_HUMAN +MAPK3,UP,P27361,MK03_HUMAN +MAPKK kinases,FPLX,000282,MAP3K +MAPKKK,FPLX,000282,MAP3K +MAPKs,FPLX,000283,MAPK +MAZ,UP,P56270,MAZ_HUMAN +Mcl-1,UP,Q07820,MCL1_HUMAN +MCM,FPLX,000284,MCM +MCP-1,UP,P0CW71, +MDM2,UP,Q00987,MDM2_HUMAN +Mdm2,UP,Q00987,MDM2_HUMAN +MDMX,UP,O15151,MDM4_HUMAN +Mdmx,UP,O15151,MDM4_HUMAN +MED14,UP,O60244,MED14_HUMAN +MED23,UP,Q9ULK4,MED23_HUMAN +MEF2 family,FPLX,000285,MEF2 +MEF2,FPLX,000285,MEF2 +MEF2C,UP,Q06413,MEF2C_HUMAN +MEK 1/2,FPLX,000286,MEK +MEK inhibitor,CHEBI,CHEBI:88286,EC 2.7.12.2 (mitogen-activated protein kinase kinase) inhibitor +MEK inhibitors,CHEBI,CHEBI:88286,EC 2.7.12.2 (mitogen-activated protein kinase kinase) inhibitor +MEK,FPLX,000286,MEK +MEK1,UP,Q02750,MP2K1_HUMAN +MEK1/2,FPLX,000286,MEK +melanin,PUBCHEM,6325610, +melanin,CHEBI,CHEBI:89634,Melanin +melatonin,CHEBI,CHEBI:16796,melatonin +melatonin,PUBCHEM,896, +membrane attack complex,FPLX,000278,MAC +membrane attack,FPLX,000278,MAC +MET,UP,P08581,MET_HUMAN +Met,UP,P08581,MET_HUMAN +metabolism,GO,GO:0008152,metabolic process +metabolism,MESH,D008660,Metabolism +metabotrophic glutamate receptor,FPLX,000193,GRM +metabotropic glutamate receptor,FPLX,000193,GRM +metastasis,MESH,D009362,Neoplasm Metastasis +Metformin,PUBCHEM,4091, +Metformin,CHEBI,CHEBI:6801,metformin +metformin,PUBCHEM,4091, +metformin,CHEBI,CHEBI:6801,metformin +Metallothionein,FPLX,000292,Metallothionein +metallothionein,FPLX,000292,Metallothionein +MG132,PUBCHEM,462382, +MG132,CHEBI,CHEBI:75142,N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal +mGluRs,FPLX,000193,GRM +MIF,UP,P14174,MIF_HUMAN +mini-chromosome maintenance complex,FPLX,000284,MCM +minichromosome maintenance complex,FPLX,000284,MCM +minichromosome maintenance protein complex,FPLX,000284,MCM +miR-101,MESH,C534072,"MIRN101 microRNA, human" +miR-101,MIRBASE,MI0000103,hsa-mir-101-1 +miR-101,HGNC,31488,MIR101-1 +miR-145,MIRBASE,MI0000461,hsa-mir-145 +miR-145,HGNC,31532,MIR145 +miR-155,MIRBASE,MI0000681,hsa-mir-155 +miR-155,HGNC,31542,MIR155 +miR-21,MIRBASE,MI0000077,hsa-mir-21 +miR-21,HGNC,31586,MIR21 +miR-7,MIRBASE,MI0000263,hsa-mir-7-1 +miR-7,HGNC,31638,MIR7-1 +MITF,UP,O75030,MITF_HUMAN +mammalian mitochondrial ribosome,FPLX,000288,Mitochondrial_Ribosome +Mitochondrial ribosome,FPLX,000288,Mitochondrial_Ribosome +Mitochondrial Ribosome,FPLX,000288,Mitochondrial_Ribosome +mitochondrial ribosomes,FPLX,000288,Mitochondrial_Ribosome +Mitochondrial ribosomes,FPLX,000288,Mitochondrial_Ribosome +Mitochondrial Ribosomes,FPLX,000288,Mitochondrial_Ribosome +mitoribosome,FPLX,000288,Mitochondrial_Ribosome +Mitoribosome,FPLX,000288,Mitochondrial_Ribosome +55S mammalian mitochondrial ribosome,FPLX,000288,Mitochondrial_Ribosome +55S mitoribosome,FPLX,000288,Mitochondrial_Ribosome +55s mitoribosome,FPLX,000288,Mitochondrial_Ribosome +55S Mitoribosome,FPLX,000288,Mitochondrial_Ribosome +55s Mitoribosome,FPLX,000288,Mitochondrial_Ribosome +small mitoribosomal subunit,FPLX,000289,MRPS +Small Mitoribosomal Subunit,FPLX,000289,MRPS +small subunit of the mammalian mitochondrial ribosome,FPLX,000289,MRPS +mitochondrial ribosomal small subunit,FPLX,000289,MRPS +large mitoribosomal subunit,FPLX,000290,MRPL +Large Mitoribosomal Subunit,FPLX,000290,MRPL +large subunit of the mammalian mitochondrial ribosome,FPLX,000290,MRPL +MGAT,FPLX,000287,MGAT +mitochondrial ribosomal large subunit,FPLX,000290,MRPL +mitochondrial membrane potential,MESH,D053078,"Membrane Potential, Mitochondrial" +mitogen activated protein kinase,FPLX,000283,MAPK +mitogen activated protein kinases,FPLX,000283,MAPK +mitogen-activated protein kinase kinase,FPLX,000281,MAP2K +mitogen-activated protein kinase,FPLX,000283,MAPK +mitogen-activated protein kinases,FPLX,000283,MAPK +Miz1,UP,Q13105,ZBT17_HUMAN +MKK4,UP,P45985,MP2K4_HUMAN +MKP-1,UP,P28562,DUS1_HUMAN +MKP3,UP,Q16828,DUS6_HUMAN +MLC,FPLX,000296,MYL +MM,MESH,D009101,Multiple Myeloma +MMC,PUBCHEM,5746, +MMC,CHEBI,CHEBI:27504,mitomycin C +MMP,FPLX,000291,MMP +MMP-2,UP,P08253,MMP2_HUMAN +MMP-9,UP,P14780,MMP9_HUMAN +MMP9,UP,P14780,MMP9_HUMAN +MMPs,FPLX,000291,MMP +Mn,CHEBI,CHEBI:29035,manganese(2+) +Mn,PUBCHEM,27854, +MST1,UP,Q13043,STK4_HUMAN +MST2,UP,Q13188,STK3_HUMAN +MT,FPLX,000292,Metallothionein +mTOR inhibitor,CHEBI,CHEBI:68481,mTOR inhibitor +mTOR inhibitors,CHEBI,CHEBI:68481,mTOR inhibitor +mTOR,UP,P42345,MTOR_HUMAN +mTORC1,FPLX,000293,mTORC1 +mTORC2,FPLX,000294,mTORC2 +MTX,UP,Q13505,MTX1_HUMAN +Mu-A,PUBCHEM,375150, +MUC1,UP,P15941,MUC1_HUMAN +mutp53,UP,P04637,P53_HUMAN +MYC,UP,P01106,MYC_HUMAN +Myc,UP,P01106,MYC_HUMAN +MYCN,UP,P04198,MYCN_HUMAN +myosin alkali light chain proteins,FPLX,000297,MYL_alkali +myosin alkali light chain,FPLX,000297,MYL_alkali +myosin heavy chain genes,FPLX,000295,MYH +myosin heavy chain isoforms,FPLX,000295,MYH +myosin heavy chain protein,FPLX,000295,MYH +Myosin heavy chain,FPLX,000295,MYH +myosin heavy chain,FPLX,000295,MYH +Myosin heavy chains,FPLX,000295,MYH +myosin heavy chains,FPLX,000295,MYH +myosin light chain protein,FPLX,000296,MYL +myosin light chain,FPLX,000296,MYL +myosin light chains,FPLX,000296,MYL +MYPT1,UP,O14974,MYPT1_HUMAN +MYST family,FPLX,000300,MYST +MYST histone acetylase,FPLX,000300,MYST +MYST proteins,FPLX,000300,MYST +N-cadherin,UP,P19022,CADH2_HUMAN +N-myc downstream regulated gene family,FPLX,000307,NDRG +N-Myc,UP,P04198,MYCN_HUMAN +N-Ras,UP,P01111,RASN_HUMAN +Na+/K+-exchanging ATPase,FPLX,000303,Na_K_ATPase +Na+/K+ATPase,FPLX,000303,Na_K_ATPase +Na/K ATPase alpha,FPLX,000057,ATP1A +Na/K ATPase α,FPLX,000057,ATP1A +Na/K-ATPase,FPLX,000303,Na_K_ATPase +NAC,PUBCHEM,443227, +NAC,CHEBI,CHEBI:7421,NAC +nAChR,FPLX,000103,CHRN +NAD(P)H oxidase,FPLX,000302,NADPH_oxidase +NAD(P)H-oxidase,FPLX,000302,NADPH_oxidase +NADH dehydrogenase (ubiquinone),FPLX,000301,NADH_dehydrogenase +NADH dehydrogenase,FPLX,000301,NADH_dehydrogenase +NADPH oxidase,FPLX,000302,NADPH_oxidase +NADPH,PUBCHEM,5884, +NADPH,CHEBI,CHEBI:16474,NADPH +NADPH,HMDB,HMDB00221, +naked cuticle,FPLX,000315,NKD +NAP,UP,P80723,BASP1_HUMAN +Natriuretic Peptide,FPLX,000304,Natriuretic_peptide +Natriuretic peptide,FPLX,000304,Natriuretic_peptide +natriuretic peptide,FPLX,000304,Natriuretic_peptide +Natriuretic Peptides,FPLX,000304,Natriuretic_peptide +Natriuretic peptides,FPLX,000304,Natriuretic_peptide +natriuretic peptides,FPLX,000304,Natriuretic_peptide +NDR family,FPLX,000307,NDRG +NDR-family,FPLX,000307,NDRG +NDRG2,UP,Q9UN36,NDRG2_HUMAN +necroptosis,GO,GO:0070266,necroptotic process +necrosis,GO,GO:0070265,necrotic cell death +necrosis,MESH,D009336,Necrosis +Nef,UP,P03406,NEF_HV1BR +NEMO,UP,Q9Y6K9,NEMO_HUMAN +neovascularization,GO,GO:0001525,angiogenesis +neovascularization,MESH,D018919,"Neovascularization, Physiologic" +Net1,UP,Q7Z628,ARHG8_HUMAN +neuregulin family,FPLX,000318,NRG +Neuregulin,FPLX,000318,NRG +neuregulin,FPLX,000318,NRG +Neuregulins,FPLX,000318,NRG +neuregulins,FPLX,000318,NRG +Neurexins,FPLX,000308,Neurexins +NF-E2,FPLX,000310,NFE +NF-E2-related factor,FPLX,000310,NFE +NF-kappaB Class 1,FPLX,000312,NFkappaB_1 +NF-kappaB class 1,FPLX,000312,NFkappaB_1 +NF-kappaB Class 2,FPLX,000313,NFkappaB_2 +NF-kappaB class 2,FPLX,000313,NFkappaB_2 +NF-kappaB Class I,FPLX,000312,NFkappaB_1 +NF-kappaB class I,FPLX,000312,NFkappaB_1 +NF-kappaB Class II,FPLX,000313,NFkappaB_2 +NF-kappaB class II,FPLX,000313,NFkappaB_2 +NF-kappaB complexes,FPLX,000311,NFkappaB +NF-kappaB dimers,FPLX,000311,NFkappaB +NF-kappaB Factors,FPLX,000311,NFkappaB +NF-kappaB factors,FPLX,000311,NFkappaB +NF-kappaB genes,FPLX,000311,NFkappaB +NF-kappaB p50,HGNC,7794,NFKB1 +NF-kappaB p65,HGNC,9955,RELA +NF-kappaB p65,UP,Q04206,TF65_HUMAN +NF-kappaB subunits,FPLX,000311,NFkappaB +NF-kappaB TFs,FPLX,000311,NFkappaB +NF-kappaB,FPLX,000311,NFkappaB +NF-kappaB1,HGNC,7794,NFKB1 +NF-kappaB2,HGNC,7795,NFKB2 +NF-kappabeta,FPLX,000311,NFkappaB +NF-kappaBp50,HGNC,7794,NFKB1 +NF-kappaBp65,HGNC,9955,RELA +NF-kappaBs,FPLX,000311,NFkappaB +NF-kB,FPLX,000311,NFkappaB +NF-Y,FPLX,000314,NFY +NF-κB Class 1,FPLX,000312,NFkappaB_1 +NF-κB class 1,FPLX,000312,NFkappaB_1 +NF-κB Class 2,FPLX,000313,NFkappaB_2 +NF-κB class 2,FPLX,000313,NFkappaB_2 +NF-κB Class I,FPLX,000312,NFkappaB_1 +NF-κB class I,FPLX,000312,NFkappaB_1 +NF-κB Class II,FPLX,000313,NFkappaB_2 +NF-κB class II,FPLX,000313,NFkappaB_2 +NF-κB complexes,FPLX,000311,NFkappaB +NF-κB dimers,FPLX,000311,NFkappaB +NF-κB Factors,FPLX,000311,NFkappaB +NF-κB factors,FPLX,000311,NFkappaB +NF-κB genes,FPLX,000311,NFkappaB +NF-κB p50,HGNC,7794,NFKB1 +NF-κB p65,HGNC,9955,RELA +NF-κB p65,UP,Q04206,TF65_HUMAN +NF-κB subunits,FPLX,000311,NFkappaB +NF-κB TFs,FPLX,000311,NFkappaB +NF-κB,FPLX,000311,NFkappaB +NF-κB1,HGNC,7794,NFKB1 +NF-κB2,HGNC,7795,NFKB2 +NF-κBp50,HGNC,7794,NFKB1 +NF-κBp65,HGNC,9955,RELA +NF-κBs,FPLX,000311,NFkappaB +NF-κβ,FPLX,000311,NFkappaB +NFAT,FPLX,000309,NFAT +NFkappaB complexes,FPLX,000311,NFkappaB +NFkappaB p50,HGNC,7794,NFKB1 +NFkappaB p65,HGNC,9955,RELA +NFkappaB,FPLX,000311,NFkappaB +NFkappaBp65,HGNC,9955,RELA +NFY,FPLX,000314,NFY +NFκB complexes,FPLX,000311,NFkappaB +NFκB p50,HGNC,7794,NFKB1 +NFκB p65,HGNC,9955,RELA +NFκB,FPLX,000311,NFkappaB +NFκBp65,HGNC,9955,RELA +NGF,UP,P01138,NGF_HUMAN +nicotine class acetylcholine receptors,FPLX,000103,CHRN +nicotinic acetylcholine receptor,FPLX,000103,CHRN +nitric oxide,PUBCHEM,145068, +nitric oxide,CHEBI,CHEBI:16480,nitric oxide +nmMLCK,UP,Q15746-1,MYLK_HUMAN +nmMLCK1,UP,Q15746-1,MYLK_HUMAN +NO,HMDB,HMDB03378, +NO,CHEBI,CHEBI:16480,nitric oxide +NO,PUBCHEM,145068, +non-ELR-CXC chemokines,FPLX,000128,CXCL_ELR_negative +NOS,FPLX,000316,NOS +Notch,FPLX,000317,Notch +Notch1,UP,P46531,NOTC1_HUMAN +NOX1,UP,Q9Y5S8,NOX1_HUMAN +NOX2,UP,P04839,CY24B_HUMAN +NOX3,UP,Q9HBY0,NOX3_HUMAN +NOX4,UP,Q9NPH5,NOX4_HUMAN +Noxa,UP,Q13794,APR_HUMAN +NPM,UP,P06748,NPM_HUMAN +NRAS,UP,P01111,RASN_HUMAN +NRF2,UP,Q16236,NF2L2_HUMAN +Nrf2,UP,Q16236,NF2L2_HUMAN +NRG1,UP,Q02297,NRG1_HUMAN +NRG1-NRG2,FPLX,000319,NRG_1_2 +NRG1/2,FPLX,000319,NRG_1_2 +NRG3-NRG4,FPLX,000320,NRG_3_4 +NRG3/4,FPLX,000320,NRG_3_4 +NRGs,FPLX,000318,NRG +NRXN,FPLX,000308,Neurexins +NTF3,UP,P20783,NTF3_HUMAN +NTRK,FPLX,000321,NTRK +NTRKs,FPLX,000321,NTRK +Nuclear factor erythroid 2-related factor,FPLX,000310,NFE +nuclear factor Y,FPLX,000314,NFY +nuclear factor-Y,FPLX,000314,NFY +Nuclear Receptor Co-Repressor,FPLX,000306,NCOR +nuclear receptor co-repressor,FPLX,000306,NCOR +Nuclear receptor corepressor,FPLX,000306,NCOR +nuclear receptor corepressor,FPLX,000306,NCOR +Nutlin-3,PUBCHEM,16755649, +Nutlin-3,CHEBI,CHEBI:46742,Nutlin-3 +NVP-BEZ235,PUBCHEM,11977753, +NVP-BEZ235,LINCS,10232-101, +NVP-BEZ235,CHEBI,CHEBI:71952,dactolisib +NVP-LDE-225,PUBCHEM,24775005, +NVP-LDE-225,CHEBI,CHEBI:90863,sonidegib +OA,CHEBI,CHEBI:37659,oleanolic acid +OA,PUBCHEM,10494, +OA,CHEBI,CHEBI:44658,okadaic acid +OA,PUBCHEM,446512, +ofalpha(2)-adrenoceptor,FPLX,000020,ADRA2 +ofα(2)-adrenoceptor,FPLX,000020,ADRA2 +OPG,UP,O00300,TR11B_HUMAN +OPN,UP,P10451,OSTP_HUMAN +ov-serpins,FPLX,000431,SERPINB +oxaliplatin,CHEBI,CHEBI:31941,oxaliplatin +oxaliplatin,PUBCHEM,6857599, +oxygen,HMDB,HMDB01377, +oxygen,CHEBI,CHEBI:15379,dioxygen +oxygen,PUBCHEM,977, +P-REX1,UP,Q8TCU6,PREX1_HUMAN +p100,HGNC,7795,NFKB2 +p105,HGNC,7794,NFKB1 +p110,FPLX,000359,PI3K_p110 +p110alpha,UP,P42336,PK3CA_HUMAN +p110beta,UP,P42338,PK3CB_HUMAN +p110α,UP,P42336,PK3CA_HUMAN +p110β,UP,P42338,PK3CB_HUMAN +p120,UP,O60716,CTND1_HUMAN +p130,UP,P56945,BCAR1_HUMAN +p16,UP,P42771,CDN2A_HUMAN +p160/SRC,FPLX,000305,NCOA +p21 Cip1,UP,P38936,CDN1A_HUMAN +p21 WAF1,UP,P38936,CDN1A_HUMAN +p21,UP,P38936,CDN1A_HUMAN +p22 phox,UP,P13498,CY24A_HUMAN +p27 Kip1,UP,P46527,CDN1B_HUMAN +p27,UP,P46527,CDN1B_HUMAN +P2X purinoreceptor,FPLX,000324,P2RX +P2X purinoreceptors,FPLX,000324,P2RX +P2X receptor,FPLX,000324,P2RX +P2X receptors,FPLX,000324,P2RX +P2X,FPLX,000324,P2RX +P2Y receptor,FPLX,000325,P2RY +p300,UP,Q09472,EP300_HUMAN +P38 MAPK,FPLX,000326,p38 +p38 MAPK,FPLX,000326,p38 +p38 MAPKs,FPLX,000326,p38 +p38,FPLX,000326,p38 +p38-MAPK,FPLX,000326,p38 +p38MAPK,FPLX,000326,p38 +p40 phox,UP,Q15080,NCF4_HUMAN +p42,UP,P28482,MK01_HUMAN +p42,UP,Q9UQ80,PA2G4_HUMAN +p47 phox,UP,P14598,NCF1_HUMAN +p50,UP,P19838,NFKB1_HUMAN +p52,HGNC,7795,NFKB2 +P53 family,FPLX,000327,p53_family +p53 Family,FPLX,000327,p53_family +p53 family,FPLX,000327,p53_family +P53,UP,P04637,P53_HUMAN +p53,UP,P04637,P53_HUMAN +p53/p63/p73 family,FPLX,000327,p53_family +p62,UP,Q13501,SQSTM_HUMAN +p63,UP,Q9H3D4,P63_HUMAN +p65,UP,Q04206,TF65_HUMAN +p66Shc,UP,P29353-1,SHC1_HUMAN +p67 phox,UP,P19878,NCF2_HUMAN +p70 S6 kinase,FPLX,000328,P70S6K +p70,UP,P23443,KS6B1_HUMAN +P70RSK,FPLX,000328,P70S6K +p70RSK,FPLX,000328,P70S6K +p70S6 kinase,UP,P23443,KS6B1_HUMAN +P70S6K,FPLX,000328,P70S6K +p70S6K,UP,P23443,KS6B1_HUMAN +p73,UP,O15350,P73_HUMAN +p85,FPLX,000360,PI3K_p85 +p85alpha,UP,P27986,P85A_HUMAN +p85α,UP,P27986,P85A_HUMAN +p90RSK,FPLX,000329,P90RSK +PA,CHEBI,CHEBI:16337,phosphatidic acid +PA,PUBCHEM,8144759, +paeoniflorin,CHEBI,CHEBI:7889,paeoniflorin +paeoniflorin,PUBCHEM,442534, +PAI-1,UP,P05121,PAI1_HUMAN +PAK,FPLX,000330,PAK +Pak,FPLX,000330,PAK +PAK1,UP,Q13153,PAK1_HUMAN +Pak1,UP,Q13153,PAK1_HUMAN +Pak2,UP,Q13177,PAK2_HUMAN +PAK4,UP,O96013,PAK4_HUMAN +palmitate,PUBCHEM,985, +palmitate,CHEBI,CHEBI:15756,hexadecanoic acid +palmitate,HMDB,HMDB00220, +PAR3,UP,Q8TEW0,PARD3_HUMAN +Parkin,UP,O60260,PRKN_HUMAN +PARP genes,FPLX,000331,PARP +PARP,UP,P09874,PARP1_HUMAN +Parp,UP,P09874,PARP1_HUMAN +PARP-1,UP,P09874,PARP1_HUMAN +PARPs,FPLX,000331,PARP +Parvin,FPLX,000332,PARV +parvin,FPLX,000332,PARV +Parvins,FPLX,000332,PARV +parvins,FPLX,000332,PARV +PATCHED,FPLX,000333,Patched +Patched,FPLX,000333,Patched +paxillin,UP,P49023,PAXI_HUMAN +PBX,FPLX,000334,PBX +Pbx,FPLX,000334,PBX +pbx,FPLX,000334,PBX +PBXs,FPLX,000334,PBX +Pca,MESH,D011471,Prostatic Neoplasms +PCNA,UP,P12004,PCNA_HUMAN +PD,MESH,D010300,Parkinson Disease +PD98509,CHEBI,CHEBI:79091,EC 2.7.11.24 (mitogen-activated protein kinase) inhibitor +PDE 2,HGNC,8777,PDE2A +PDE 3,FPLX,000337,PDE3 +PDE,FPLX,000335,PDE +PDE1 family,FPLX,000336,PDE1 +PDE1,FPLX,000336,PDE1 +PDE3 family,FPLX,000337,PDE3 +PDE3,FPLX,000337,PDE3 +PDE4 family,FPLX,000338,PDE4 +PDE4 isoforms,FPLX,000338,PDE4 +PDE4,FPLX,000338,PDE4 +PDE5,HGNC,8784,PDE5A +PDE6 family,FPLX,000339,PDE6 +PDE6,FPLX,000339,PDE6 +PDE7,FPLX,000340,PDE7 +PDE8,FPLX,000341,PDE8 +PDEs,FPLX,000335,PDE +PDGF CC,FPLX,000350,PDGF_CC +PDGF DD,FPLX,000351,PDGF_DD +PDGF,FPLX,000342,PDGF +PDGF-AA,FPLX,000347,PDGF_AA +PDGF-aa,FPLX,000347,PDGF_AA +PDGF-AB,FPLX,000348,PDGF_AB +PDGF-ab,FPLX,000348,PDGF_AB +PDGF-BB,FPLX,000349,PDGF_BB +PDGF-bb,FPLX,000349,PDGF_BB +PDGF-CC,FPLX,000350,PDGF_CC +PDGF-cc,FPLX,000350,PDGF_CC +PDGF-DD,FPLX,000351,PDGF_DD +PDGF-dd,FPLX,000351,PDGF_DD +PDGFAA,FPLX,000347,PDGF_AA +PDGFAB,FPLX,000348,PDGF_AB +PDGFBB,FPLX,000349,PDGF_BB +PDGFR,FPLX,000343,PDGFR +PDGFR-AA,FPLX,000344,PDGFR_AA +PDGFR-AB,FPLX,000345,PDGFR_AB +PDGFR-alphaalpha,FPLX,000344,PDGFR_AA +PDGFR-alphabeta,FPLX,000345,PDGFR_AB +PDGFR-BB,FPLX,000346,PDGFR_BB +PDGFR-betabeta,FPLX,000346,PDGFR_BB +PDGFR-αα,FPLX,000344,PDGFR_AA +PDGFR-αβ,FPLX,000345,PDGFR_AB +PDGFR-ββ,FPLX,000346,PDGFR_BB +PDGFRalpha,UP,P16234,PGFRA_HUMAN +PDGFRalphaalpha,FPLX,000344,PDGFR_AA +PDGFRalphabeta,FPLX,000345,PDGFR_AB +PDGFRbeta,UP,P09619,PGFRB_HUMAN +PDGFRbetabeta,FPLX,000346,PDGFR_BB +PDGFRβ,UP,P09619,PGFRB_HUMAN +PDGFRα,UP,P16234,PGFRA_HUMAN +PDGFRαα,FPLX,000344,PDGFR_AA +PDGFRαβ,FPLX,000345,PDGFR_AB +PDGFRββ,FPLX,000346,PDGFR_BB +PDH,FPLX,000352,PDH +PDK,FPLX,000353,PDK +PDK,UP,O15530,PDPK1_HUMAN +PDK1,UP,O15530,PDPK1_HUMAN +PDKs,FPLX,000353,PDK +PDPK1,UP,O15530,PDPK1_HUMAN +PDT,MESH,D010778,Photochemotherapy +PEA-15,UP,Q15121,PEA15_HUMAN +PERK,UP,Q9NZJ5,E2AK3_HUMAN +Peroxiredoxin,FPLX,000388,PRDX +peroxiredoxin,FPLX,000388,PRDX +Peroxiredoxins,FPLX,000388,PRDX +peroxiredoxins,FPLX,000388,PRDX +Pertussis toxin,FPLX,000354,Pertussis_toxin +pertussis toxin,FPLX,000354,Pertussis_toxin +PF-3758309,PUBCHEM,25227462, +PF-3758309,CHEBI,CHEBI:93751,"N-[(1S)-2-(dimethylamino)-1-phenylethyl]-6,6-dimethyl-3-[(2-methyl-4-thieno[3,2-d]pyrimidinyl)amino]-1,4-dihydropyrrolo[3,4-c]pyrazole-5-carboxamide" +PGC-1alpha,UP,Q9UBK2,PRGC1_HUMAN +PGC-1α,UP,Q9UBK2,PRGC1_HUMAN +PGE 2,CHEBI,CHEBI:73965,prostaglandin E2-UM +PGE 2,PUBCHEM,161468, +PGE2,UP,P35408,PE2R4_HUMAN +phenformin,PUBCHEM,8249, +phenformin,CHEBI,CHEBI:8064,phenformin +PhK,FPLX,000356,PhK +phosphatase,FPLX,000357,Phosphatase +phosphatidylinositol 3-kinase,FPLX,000358,PI3K +phosphatidylinositol,CHEBI,CHEBI:28874,phosphatidylinositol +phosphatidylinositol,MESH,D010716,Phosphatidylinositols +phospho-ERK1/2,FPLX,000161,ERK +Phosphodiesterase 1,FPLX,000336,PDE1 +phosphodiesterase 1,FPLX,000336,PDE1 +Phosphodiesterase 2,HGNC,8777,PDE2A +phosphodiesterase 2,HGNC,8777,PDE2A +Phosphodiesterase 3,FPLX,000337,PDE3 +phosphodiesterase 3,FPLX,000337,PDE3 +Phosphodiesterase 4,FPLX,000338,PDE4 +phosphodiesterase 4,FPLX,000338,PDE4 +Phosphodiesterase 5,HGNC,8784,PDE5A +phosphodiesterase 5,HGNC,8784,PDE5A +Phosphodiesterase 6,FPLX,000339,PDE6 +phosphodiesterase 6,FPLX,000339,PDE6 +Phosphodiesterase 7,FPLX,000340,PDE7 +phosphodiesterase 7,FPLX,000340,PDE7 +Phosphodiesterase 8,FPLX,000341,PDE8 +phosphodiesterase 8,FPLX,000341,PDE8 +Phosphodiesterase,FPLX,000335,PDE +phosphodiesterase,FPLX,000335,PDE +Phosphodiesterase-1,FPLX,000336,PDE1 +phosphodiesterase-1,FPLX,000336,PDE1 +Phosphodiesterase-2,HGNC,8777,PDE2A +phosphodiesterase-2,HGNC,8777,PDE2A +Phosphodiesterase-3,FPLX,000337,PDE3 +phosphodiesterase-3,FPLX,000337,PDE3 +Phosphodiesterase-4,FPLX,000338,PDE4 +phosphodiesterase-4,FPLX,000338,PDE4 +Phosphodiesterase-5,HGNC,8784,PDE5A +phosphodiesterase-5,HGNC,8784,PDE5A +Phosphodiesterase-6,FPLX,000339,PDE6 +phosphodiesterase-6,FPLX,000339,PDE6 +Phosphodiesterase-7,FPLX,000340,PDE7 +phosphodiesterase-7,FPLX,000340,PDE7 +Phosphodiesterase-8,FPLX,000341,PDE8 +phosphodiesterase-8,FPLX,000341,PDE8 +Phosphodiesterases,FPLX,000335,PDE +phosphodiesterases,FPLX,000335,PDE +Phospholipase A2 Group IV,FPLX,000368,PLA2G4 +phospholipase A2 group-II,FPLX,000367,PLA2G2 +phospholipase A2 group-IV,FPLX,000368,PLA2G4 +phospholipase A2,FPLX,000366,PLA2 +Phospholipase C,FPLX,000369,PLC +phospholipase C,FPLX,000369,PLC +Phospholipase C-beta,FPLX,000370,PLCB +phospholipase C-beta,FPLX,000370,PLCB +Phospholipase C-delta,FPLX,000371,PLCD +phospholipase C-delta,FPLX,000371,PLCD +Phospholipase C-β,FPLX,000370,PLCB +phospholipase C-β,FPLX,000370,PLCB +Phospholipase C-δ,FPLX,000371,PLCD +phospholipase C-δ,FPLX,000371,PLCD +Phospholipase Cbeta,FPLX,000370,PLCB +phospholipase Cbeta,FPLX,000370,PLCB +Phospholipase Cdelta,FPLX,000371,PLCD +phospholipase Cdelta,FPLX,000371,PLCD +Phospholipase Cβ,FPLX,000370,PLCB +phospholipase Cβ,FPLX,000370,PLCB +Phospholipase Cδ,FPLX,000371,PLCD +phospholipase Cδ,FPLX,000371,PLCD +Phospholipase D,FPLX,000373,PLD +phospholipase D,FPLX,000373,PLD +Phospholipase-C,FPLX,000369,PLC +phospholipase-C,FPLX,000369,PLC +Phosphorylase kinase,FPLX,000356,PhK +phosphorylase kinase,FPLX,000356,PhK +PI 3-kinase,FPLX,000358,PI3K +PI 3-kinases,FPLX,000358,PI3K +PI,CHEBI,CHEBI:28874,phosphatidylinositol +PI,MESH,D010716,Phosphatidylinositols +PI3-kinase,FPLX,000358,PI3K +PI3K inhibitor,CHEBI,CHEBI:84801,EC 2.7.1.127 (inositol-trisphosphate 3-kinase) inhibitor +PI3K p110 subunit,FPLX,000359,PI3K_p110 +PI3K,FPLX,000358,PI3K +PI3Kinase,FPLX,000358,PI3K +PIK3C,FPLX,000359,PI3K_p110 +PIK3CA,UP,P42336,PK3CA_HUMAN +PIK3R,FPLX,000361,PIK3R_I +PIM,FPLX,000362,PIM +Pin1,UP,Q13526,PIN1_HUMAN +PIP,CHEBI,CHEBI:28765,phosphatidylinositol phosphate +PIP3,MESH,C060974,"phosphatidylinositol 3,4,5-triphosphate" +PIP3,CHEBI,CHEBI:60169,phosphatidylinositol trisphosphate +PK-A,FPLX,000363,PKA +PKA catalytic subunit,FPLX,000389,PRKAC +PKA catalytic subunits,FPLX,000389,PRKAC +PKA regulatory subunit,FPLX,000390,PRKAR +PKA regulatory subunits,FPLX,000390,PRKAR +PKA,FPLX,000363,PKA +PKB,FPLX,000023,AKT +PKB-Akt,FPLX,000023,AKT +PKB/Akt,FPLX,000023,AKT +PKC,FPLX,000364,PKC +PKCalpha,UP,P17252,KPCA_HUMAN +PKCdelta,UP,Q05655,KPCD_HUMAN +PKCepsilon,UP,Q02156,KPCE_HUMAN +PKCα,UP,P17252,KPCA_HUMAN +PKCε,UP,Q02156,KPCE_HUMAN +PKCδ,UP,Q05655,KPCD_HUMAN +PKG,FPLX,000391,PRKG +PKI,FPLX,000365,PKI +PKM2,UP,P14618,KPYM_HUMAN +PKR,UP,P19525,E2AK2_HUMAN +PLA2G2,FPLX,000367,PLA2G2 +PLA2g2,FPLX,000367,PLA2G2 +PLA2G4,FPLX,000368,PLA2G4 +PLB,UP,P26678,PPLA_HUMAN +PLC,FPLX,000369,PLC +PLC-gamma,FPLX,000372,PLCG +PLC-gamma1,UP,P19174,PLCG1_HUMAN +PLC-γ,FPLX,000372,PLCG +PLC-γ1,UP,P19174,PLCG1_HUMAN +PLCgamma1,UP,P19174,PLCG1_HUMAN +PLCγ1,UP,P19174,PLCG1_HUMAN +PLK1,UP,P53350,PLK1_HUMAN +Plk1,UP,P53350,PLK1_HUMAN +PLX,PUBCHEM,42611257, +PLX,CHEBI,CHEBI:63637,vemurafenib +PLX4032,PUBCHEM,42611257, +PLX4032,CHEBI,CHEBI:63637,vemurafenib +PML,UP,P29590,PML_HUMAN +Pol delta,FPLX,000141,DNA_polymerase_delta +pol delta,FPLX,000141,DNA_polymerase_delta +Pol I,FPLX,000416,RNApo_I +Pol δ,FPLX,000141,DNA_polymerase_delta +pol δ,FPLX,000141,DNA_polymerase_delta +Poly(ADP-ribose) polymerase,FPLX,000331,PARP +Poly(ADP-ribose) polymerases,FPLX,000331,PARP +polycomb Repressive Complex (PRC) 1,FPLX,000386,PRC1_complex +Polycomb Repressive Complex 1,FPLX,000386,PRC1_complex +Polycomb repressive complex 1,FPLX,000386,PRC1_complex +polycomb repressive complex 1,FPLX,000386,PRC1_complex +Polycomb Repressive Complex 2,FPLX,000387,PRC2_complex +Polycomb repressive complex 2,FPLX,000387,PRC2_complex +polycomb repressive complex 2,FPLX,000387,PRC2_complex +Polycomb repressive complex PRC1,FPLX,000386,PRC1_complex +Polycomb repressive complex PRC2,FPLX,000387,PRC2_complex +Polycomb Repressive Complexes 1,FPLX,000386,PRC1_complex +Polycomb Repressive Complexes 2,FPLX,000387,PRC2_complex +Polycomb-repressive complex 1,FPLX,000386,PRC1_complex +Polycomb-repressive complex 2,FPLX,000387,PRC2_complex +PP1 regulator,FPLX,000376,PPP1 +PP1,FPLX,000376,PPP1 +PP1C,FPLX,000377,PPP1C +PP1c,FPLX,000377,PPP1C +PP1R,FPLX,000378,PPP1R +PP1r,FPLX,000378,PPP1R +PP2 phosphatases,FPLX,000379,PPP2 +PP2,CHEBI,CHEBI:78331,PP2 +PP2,PUBCHEM,4878, +PP2,FPLX,000379,PPP2 +PP242,PUBCHEM,135565635, +PP242,CHEBI,CHEBI:90679,torkinib +PP2A catalytic C subunit,FPLX,000380,PPP2C +PP2A regulatory subunit A,FPLX,000381,PPP2R_A +PP2A regulatory subunit B,FPLX,000382,PPP2R_B +PP2A,FPLX,000379,PPP2 +PP2A-C,FPLX,000380,PPP2C +PP2Ac,FPLX,000380,PPP2C +PP2B catalytic subunit,FPLX,000384,PPP3C +PP2B,FPLX,000383,PPP3 +PPAR,FPLX,000375,PPAR +PPAR-gamma,UP,P37231,PPARG_HUMAN +PPAR-γ,UP,P37231,PPARG_HUMAN +PPARgamma,UP,P37231,PPARG_HUMAN +PPARγ,UP,P37231,PPARG_HUMAN +PPP1,FPLX,000376,PPP1 +PPP1C,FPLX,000377,PPP1C +PR,UP,P06401,PRGR_HUMAN +PRAS40,UP,Q96B36,AKTS1_HUMAN +pRB,UP,P06400,RB_HUMAN +pRb,UP,P06400,RB_HUMAN +PRC1,FPLX,000386,PRC1_complex +PRC1,UP,O43663,PRC1_HUMAN +PRC2,FPLX,000387,PRC2_complex +PRKAA,FPLX,000044,AMPK_alpha +PRKAB,FPLX,000045,AMPK_beta +PRKAG,FPLX,000046,AMPK_gamma +PRL-3,UP,O75365,TP4A3_HUMAN +Profilin,FPLX,000355,PFN +profilin,FPLX,000355,PFN +Profilins,FPLX,000355,PFN +profilins,FPLX,000355,PFN +progesterone,CHEBI,CHEBI:17026,progesterone +progesterone,PUBCHEM,5994, +Proliferation,GO,GO:0008283,cell population proliferation +Proliferation,MESH,D049109,Cell Proliferation +proliferation,GO,GO:0008283,cell population proliferation +proliferation,MESH,D049109,Cell Proliferation +Propionyl-CoA carboxylase,FPLX,000392,Propionyl_CoA_carboxylase +propionyl-CoA carboxylase,FPLX,000392,Propionyl_CoA_carboxylase +prostaglandin E receptor,FPLX,000395,PTGER +protease,FPLX,000393,Protease +proteasome endopeptidase,FPLX,000394,Proteasome +proteasome,FPLX,000394,Proteasome +protein farnesyltransferase,FPLX,000172,FNT +Protein kinase A catalytic subunit,FPLX,000389,PRKAC +protein kinase A catalytic subunit,FPLX,000389,PRKAC +Protein kinase A catalytic subunits,FPLX,000389,PRKAC +protein kinase A catalytic subunits,FPLX,000389,PRKAC +Protein kinase A regulatory subunit,FPLX,000390,PRKAR +protein kinase A regulatory subunit,FPLX,000390,PRKAR +Protein kinase A regulatory subunits,FPLX,000390,PRKAR +protein kinase A regulatory subunits,FPLX,000390,PRKAR +protein kinase A,FPLX,000363,PKA +protein kinase C,FPLX,000364,PKC +protein kinase G,FPLX,000391,PRKG +protein phosphatase 2,FPLX,000379,PPP2 +protein phosphatase 2B,FPLX,000383,PPP3 +proteolysis,GO,GO:0006508,proteolysis +proteolysis,MESH,D059748,Proteolysis +PTC,UP,P18502,PTC_DROME +Ptc,UP,P18502,PTC_DROME +ptc,UP,P18502,PTC_DROME +PTEN,UP,P60484,PTEN_HUMAN +Pten,UP,P60484,PTEN_HUMAN +PTP1B,UP,P18031,PTN1_HUMAN +PTX,FPLX,000354,Pertussis_toxin +PTX3,HGNC,9692,PTX3 +PTX3,UP,P26022,PTX3_HUMAN +PUMA,UP,Q96PG8,BBC3B_HUMAN +PYG,FPLX,000396,PYG +Pyk2,UP,Q14289,FAK2_HUMAN +pyruvate dehydrogenase (acetyl-transferring),FPLX,000352,PDH +Pyruvate dehydrogenase kinase,FPLX,000353,PDK +pyruvate dehydrogenase kinase,FPLX,000353,PDK +quercetin,CHEBI,CHEBI:16243,quercetin +quercetin,PUBCHEM,5280343, +RA,PUBCHEM,5538, +RA,CHEBI,CHEBI:26536,retinoic acid +RA,HMDB,HMDB06219, +Rab GTPase,FPLX,000397,RAB +Rab GTPases,FPLX,000397,RAB +rab GTPases,FPLX,000397,RAB +rab proteins,FPLX,000397,RAB +RAB,FPLX,000397,RAB +Rab,FPLX,000397,RAB +rab,FPLX,000397,RAB +Rabs,FPLX,000397,RAB +RAC,FPLX,000398,RAC +Rac,UP,P63000,RAC1_HUMAN +RAC1,UP,P63000,RAC1_HUMAN +Rac1,UP,P63000,RAC1_HUMAN +RAD51,UP,Q06609,RAD51_HUMAN +Rad51,UP,Q06609,RAD51_HUMAN +Rad52,UP,P43351,RAD52_HUMAN +RAF inhibitors,CHEBI,CHEBI:75047,B-Raf inhibitor +RAF,FPLX,000399,RAF +Raf,FPLX,000399,RAF +Raf-1,UP,P04049,RAF1_HUMAN +RAGE,UP,Q15109,RAGE_HUMAN +RAL family,FPLX,000400,RAL +Ral family,FPLX,000400,RAL +RAL guanine nucleotide dissociation stimulator like,FPLX,000413,RGL +Ral guanine nucleotide dissociation stimulator like,FPLX,000413,RGL +ral guanine nucleotide dissociation stimulator like,FPLX,000413,RGL +RAL isoforms,FPLX,000400,RAL +Ral isoforms,FPLX,000400,RAL +RAL proteins,FPLX,000400,RAL +Ral proteins,FPLX,000400,RAL +RAL,FPLX,000400,RAL +RAL,HGNC,9839,RALA +RalA,UP,P11233,RALA_HUMAN +RALGDS-like,FPLX,000413,RGL +RANKL,UP,O14788,TNF11_HUMAN +Rap guanine nucleotide exchange factor,FPLX,000402,RAPGEF +Rap guanine nucleotide exchange factors,FPLX,000402,RAPGEF +Rap1,FPLX,000401,RAP1 +Rapamycin,PUBCHEM,5284616, +Rapamycin,CHEBI,CHEBI:9168,sirolimus +rapamycin,PUBCHEM,5284616, +rapamycin,CHEBI,CHEBI:9168,sirolimus +RapGEFs,FPLX,000402,RAPGEF +Raptor,UP,Q8N122,RPTOR_HUMAN +raptor,UP,Q8N122,RPTOR_HUMAN +RAR,FPLX,000403,RAR +RAS association domain family,FPLX,000410,RASSF +Ras association domain family,FPLX,000410,RASSF +Ras GTPase,FPLX,000404,RAS +RAS,FPLX,000404,RAS +Ras,FPLX,000404,RAS +RAS-association domain family,FPLX,000410,RASSF +Ras-association domain family,FPLX,000410,RASSF +RASA,FPLX,000405,RASA +RASAL,FPLX,000406,RASAL +RasGAP,FPLX,000407,RasGAP +RasGAPs,FPLX,000407,RasGAP +RASGRF,FPLX,000408,RASGRF +RASGRP,FPLX,000409,RASGRP +RASSF family,FPLX,000410,RASSF +RASSF1A,UP,Q9NS23,RASF1_HUMAN +RB,UP,P06400,RB_HUMAN +Rb,UP,P06400,RB_HUMAN +RB1,UP,P06400,RB_HUMAN +Rb1,UP,P06400,RB_HUMAN +receptor tyrosine kinase-like orphan receptor,FPLX,000420,ROR +receptor tyrosine kinase-like orphan receptors,FPLX,000420,ROR +REDD1,UP,Q9NX09,DDIT4_HUMAN +regulatory A subunit of PP2A,FPLX,000381,PPP2R_A +regulatory B subunit of PP2A,FPLX,000382,PPP2R_B +regulatory family X,FPLX,000412,RFX +regulatory myosin light chain,FPLX,000298,MYL_regulatory +regulatory subunit of calcineurin,FPLX,000385,PPP3R +RelA,UP,Q04206,TF65_HUMAN +replication factor C,FPLX,000411,RFC +Replication protein A,FPLX,000421,RPA +replication protein A,FPLX,000421,RPA +RES,PUBCHEM,5281611, +Resveratrol,PUBCHEM,445154, +Resveratrol,CHEBI,CHEBI:27881,resveratrol +resveratrol,PUBCHEM,445154, +resveratrol,CHEBI,CHEBI:27881,resveratrol +RET,UP,P07949,RET_HUMAN +retinoblastoma protein,UP,P06400,RB_HUMAN +retinoic acid receptors,FPLX,000403,RAR +retinoid X receptors,FPLX,000424,RXR +retinoid-X receptor,FPLX,000424,RXR +RF-C,FPLX,000411,RFC +RF-X,FPLX,000412,RFX +RFC,FPLX,000411,RFC +RFX family,FPLX,000412,RFX +RFX proteins,FPLX,000412,RFX +RFX,FPLX,000412,RFX +Rheb,UP,Q15382,RHEB_HUMAN +Rho family,FPLX,000414,RHO +RHO,FPLX,000414,RHO +Rho,UP,P61586,RHOA_HUMAN +Rho-GDI,FPLX,000415,RhoGDI +RhoA,UP,P61586,RHOA_HUMAN +RhoB,UP,P62745,RHOB_HUMAN +RhoC,UP,P08134,RHOC_HUMAN +RHOGDI,FPLX,000415,RhoGDI +RhoGDI,FPLX,000415,RhoGDI +rhoGDI,FPLX,000415,RhoGDI +RhoGDIs,FPLX,000415,RhoGDI +ribosomal protein S6,UP,P62753,RS6_HUMAN +ribosomal protein S6,IP,IPR000529, +RICTOR,UP,Q6R327,RICTR_HUMAN +Rictor,UP,Q6R327,RICTR_HUMAN +RIG-I,UP,O95786,DDX58_HUMAN +RIP1,UP,Q13546,RIPK1_HUMAN +RKIP,UP,P30086,PEBP1_HUMAN +RNA polymerase 1,FPLX,000416,RNApo_I +RNA polymerase I,FPLX,000416,RNApo_I +RNA polymerase II,FPLX,000417,RNApo_II +RNAP II,FPLX,000417,RNApo_II +ROCK,FPLX,000419,ROCK +ROCK1,UP,Q13464,ROCK1_HUMAN +ROCK2,UP,O75116,ROCK2_HUMAN +ROR,FPLX,000420,ROR +RORs,FPLX,000420,ROR +ROS,MESH,D017382,Reactive Oxygen Species +ROS,UP,P08922,ROS1_HUMAN +rosiglitazone,CHEBI,CHEBI:50122,rosiglitazone +rosiglitazone,PUBCHEM,77999, +rottlerin,CHEBI,CHEBI:8899,rottlerin +rottlerin,PUBCHEM,5281847, +RPA,FPLX,000421,RPA +rPKA,FPLX,000390,PRKAR +RPS6KA,FPLX,000329,P90RSK +RSK,FPLX,000422,RSK +RSK2,UP,P51812,KS6A3_HUMAN +RTA,UP,O43251,RFOX2_HUMAN +RTKs,FPLX,000423,RTK +RUNX2,UP,Q13950,RUNX2_HUMAN +rutin,CHEBI,CHEBI:28527,rutin +rutin,PUBCHEM,5280805, +RXR,FPLX,000424,RXR +S100,FPLX,000425,S100 +S100A,FPLX,000426,S100A +S100a,FPLX,000426,S100A +S1P receptor,FPLX,000427,S1PR +S1PR,FPLX,000427,S1PR +S6,UP,P62753,RS6_HUMAN +S6,IP,IPR000529, +S6K,FPLX,000328,P70S6K +S6K1,UP,P23443,KS6B1_HUMAN +SAA,FPLX,000428,SAA +SAC,GO,GO:0033316,meiotic spindle assembly checkpoint +SAF-1,UP,P56270,MAZ_HUMAN +SAHA,PUBCHEM,5311, +SAHA,CHEBI,CHEBI:45716,vorinostat +SAHA,CHEMBL,CHEMBL98, +sarcoplasmic/endoplasmic reticulum calcium ATPase,FPLX,000430,SERCA +SB203580,PUBCHEM,176155, +SB203580,CHEBI,CHEBI:90705,SB 203580 +SCF,UP,P21583,SCF_HUMAN +senescence,GO,GO:0090398,cellular senescence +senescence,MESH,D016922,Cellular Senescence +SERCA,FPLX,000430,SERCA +SERCAs,FPLX,000430,SERCA +SFK,FPLX,000451,SRC +SFN,CHEBI,CHEBI:47807,sulforaphane +SFN,PUBCHEM,5350, +Shc family,FPLX,000432,SHC +SHC,FPLX,000432,SHC +Shc,FPLX,000432,SHC +shikonin,CHEBI,CHEBI:81068,Shikonin +shikonin,PUBCHEM,479503, +SHP-2,UP,Q06124,PTN11_HUMAN +SHP2,UP,Q06124,PTN11_HUMAN +Shp2,UP,Q06124,PTN11_HUMAN +Sialytransferase,FPLX,000202,GTF_family_29 +Sialytransferases,FPLX,000202,GTF_family_29 +sialytransferase,FPLX,000202,GTF_family_29 +sialytransferases,FPLX,000202,GTF_family_29 +signal transduction,GO,GO:0007165,signal transduction +signal transduction,MESH,D015398,Signal Transduction +simvastatin,CHEBI,CHEBI:9150,simvastatin +simvastatin,PUBCHEM,54454, +SIRT1,UP,Q96EB6,SIR1_HUMAN +Sirt1,UP,Q96EB6,SIR1_HUMAN +Skp2,UP,Q13309,SKP2_HUMAN +SLC2,FPLX,000434,SLC2A +slow myosin,FPLX,000299,MYL_slow +SLP-76,UP,Q13094,LCP2_HUMAN +SLRP,FPLX,000435,SLRP +SLRPs,FPLX,000435,SLRP +SLRR,FPLX,000435,SLRP +SLRRs,FPLX,000435,SLRP +SMAD 2/3,FPLX,000443,SMAD2_3 +SMAD,FPLX,000441,SMAD +Smad,FPLX,000441,SMAD +smad,FPLX,000441,SMAD +Smad2,UP,Q15796,SMAD2_HUMAN +smad2,UP,Q15796,SMAD2_HUMAN +SMAD2/3,FPLX,000443,SMAD2_3 +Smad2/3,FPLX,000443,SMAD2_3 +Smad3,UP,P84022,SMAD3_HUMAN +Smad4,UP,Q13485,SMAD4_HUMAN +small HSPs,FPLX,000245,HSPB +small leucine rich proteoglycan family,FPLX,000435,SLRP +small leucine rich proteoglycan,FPLX,000435,SLRP +small leucine rich proteoglycans,FPLX,000435,SLRP +small leucine-rich proteoglycan family,FPLX,000435,SLRP +small leucine-rich proteoglycan,FPLX,000435,SLRP +small leucine-rich proteoglycans,FPLX,000435,SLRP +SMC1,FPLX,000444,SMC1 +Smc1,FPLX,000444,SMC1 +SNAI family,FPLX,000446,SNAI +SNAI,FPLX,000446,SNAI +Snail,UP,O95863,SNAI1_HUMAN +SOD,FPLX,000447,SOD +Sorafenib,PUBCHEM,216239, +Sorafenib,CHEBI,CHEBI:50924,sorafenib +sorafenib,PUBCHEM,216239, +sorafenib,CHEBI,CHEBI:50924,sorafenib +SOS,FPLX,000448,SOS +Sos-1,UP,Q07889,SOS1_HUMAN +SOS1,UP,Q07889,SOS1_HUMAN +Sos1,UP,Q07889,SOS1_HUMAN +SOX2,UP,P48431,SOX2_HUMAN +Sp1,UP,P08047,SP1_HUMAN +SP600125,PUBCHEM,8515, +SP600125,CHEBI,CHEBI:90695,"anthra[1,9-cd]pyrazol-6(2H)-one" +SPC,CHEBI,CHEBI:17689,sphingosine-1-phosphocholine +SPC,PUBCHEM,9847290, +Sphingosine 1-phosphate receptor,FPLX,000427,S1PR +sphingosine-1-phosphate receptors,FPLX,000427,S1PR +SPRED,FPLX,000449,SPRED +SPRY,FPLX,000450,SPRY +SR Ca(2+)-ATPase,FPLX,000430,SERCA +Src family kinase,FPLX,000451,SRC +Src family,FPLX,000451,SRC +src kinases,FPLX,000451,SRC +SRC,UP,P12931,SRC_HUMAN +Src,UP,P12931,SRC_HUMAN +SRC-family kinases,FPLX,000451,SRC +Src-kinases,FPLX,000451,SRC +SREBF family,FPLX,000452,SREBF +SREBF,FPLX,000452,SREBF +SRF,UP,P11831,SRF_HUMAN +StAR,HGNC,11359,STAR +StAR,UP,P49675,STAR_HUMAN +STAT,FPLX,000453,STAT +STAT1,UP,P42224,STAT1_HUMAN +STAT3,UP,P40763,STAT3_HUMAN +Stat3,UP,P40763,STAT3_HUMAN +STAT5,FPLX,000454,STAT5 +Stat5,FPLX,000454,STAT5 +STATs,FPLX,000453,STAT +Staurosporine,PUBCHEM,44259, +Staurosporine,CHEBI,CHEBI:15738,staurosporine +staurosporine,PUBCHEM,44259, +staurosporine,CHEBI,CHEBI:15738,staurosporine +stearoyl-CoA 9-desaturase,FPLX,000429,SCD +Stearoyl-CoA desaturase,FPLX,000429,SCD +stearoyl-CoA desaturase,FPLX,000429,SCD +sterol regulatory element binding protein,FPLX,000452,SREBF +sterol regulatory element-binding factor,FPLX,000452,SREBF +STING,UP,Q86WV6,STING_HUMAN +STT3,FPLX,000455,STT3 +STZ,PUBCHEM,29327, +STZ,UP,Q11206,SIA4C_HUMAN +succinate dehydrogenase (ubiquinone),FPLX,000502,ETC_complex_II +succinate dehydrogenase,FPLX,000502,ETC_complex_II +Sulfonylurea Receptor,FPLX,000456,Sulfonylurea_receptor +sulfonylurea receptor,FPLX,000456,Sulfonylurea_receptor +sulfonylurea receptors,FPLX,000456,Sulfonylurea_receptor +sulforaphane,PUBCHEM,5350, +sulforaphane,CHEBI,CHEBI:47807,sulforaphane +superoxide,CHEBI,CHEBI:18421,superoxide +superoxide,PUBCHEM,5359597, +SUR,FPLX,000456,Sulfonylurea_receptor +Survivin,UP,O15392,BIRC5_HUMAN +survivin,UP,O15392,BIRC5_HUMAN +SWI and SNF complex,FPLX,000457,SWI_SNF +SWI/SNF complex,FPLX,000457,SWI_SNF +SWI/SNF,FPLX,000457,SWI_SNF +SWI/SNF-like,FPLX,000457,SWI_SNF +Syk,UP,P43405,KSYK_HUMAN +SYNJ2,UP,O15056,SYNJ2_HUMAN +T-cell factor (TCF)/lymphoid enhancer factor,FPLX,000460,TCF_LEF +TAK1,UP,O43318,M3K7_HUMAN +TAK165,PUBCHEM,6444692, +tamoxifen,PUBCHEM,2733526, +tamoxifen,CHEBI,CHEBI:41774,tamoxifen +TAP transporter,FPLX,000459,TAP +TAP,FPLX,000459,TAP +TAp73,UP,O15350,P73_HUMAN +TAS-116,PUBCHEM,67501411, +Tat,UP,P04608,TAT_HV1H2 +tau,UP,P10636,TAU_HUMAN +Tax,UP,P03409,TAX_HTL1A +TBK1,UP,Q9UHD2,TBK1_HUMAN +TCF,FPLX,000460,TCF_LEF +Tcf,FPLX,000460,TCF_LEF +Tcf/Lef,FPLX,000460,TCF_LEF +TCR,FPLX,000461,TCR +TDRG1,UP,Q3Y452,TDRG1_HUMAN +telomerase,UP,O14746,TERT_HUMAN +Temozolomide,CHEBI,CHEBI:72564,temozolomide +Temozolomide,PUBCHEM,5394, +temozolomide,CHEBI,CHEBI:72564,temozolomide +temozolomide,PUBCHEM,5394, +Tenascin,FPLX,000473,TN +tenascin,FPLX,000473,TN +TFDP,FPLX,000464,TFDP +TFIIE,FPLX,000196,GTF2E +TFIIF,FPLX,000197,GTF2F +TGF beta receptor,FPLX,000466,TGFBR +TGF beta,FPLX,000465,TGFB +TGF β receptor,FPLX,000466,TGFBR +TGF β,FPLX,000465,TGFB +TGF-alpha,UP,P01135,TGFA_HUMAN +TGF-b,FPLX,000465,TGFB +TGF-beta family,FPLX,000465,TGFB +TGF-beta receptor,FPLX,000466,TGFBR +TGF-beta receptors,FPLX,000466,TGFBR +TGF-beta,FPLX,000465,TGFB +TGF-beta1,UP,P01137,TGFB1_HUMAN +TGF-β receptor,FPLX,000466,TGFBR +TGF-β receptors,FPLX,000466,TGFBR +TGF-β,FPLX,000465,TGFB +TGF-α,UP,P01135,TGFA_HUMAN +TGF-β1,UP,P01137,TGFB1_HUMAN +TGFalpha,UP,P01135,TGFA_HUMAN +TGFB family,FPLX,000465,TGFB +TGFB,FPLX,000465,TGFB +TGFbeta,FPLX,000465,TGFB +TGFbeta1,UP,P01137,TGFB1_HUMAN +TGFBR family,FPLX,000466,TGFBR +TGFBR,FPLX,000466,TGFBR +TGFβ receptor,FPLX,000466,TGFBR +TGFβ receptors,FPLX,000466,TGFBR +TGFβ,FPLX,000465,TGFB +TGFα,UP,P01135,TGFA_HUMAN +TGFβ1,UP,P01137,TGFB1_HUMAN +thapsigargin,PUBCHEM,446378, +thapsigargin,CHEBI,CHEBI:9516,thapsigargin +Thioredoxin reductase,FPLX,000488,TXNRD +thioredoxin reductase,FPLX,000488,TXNRD +Thioredoxin,FPLX,000487,TXN +thioredoxin,FPLX,000487,TXN +Thioredoxin,UP,P10599,THIO_HUMAN +thioredoxin,UP,P10599,THIO_HUMAN +thioredoxins,FPLX,000487,TXN +thrombin,IP,IPR003966, +thrombin,UP,P00734,THRB_HUMAN +thrombin-anti-thrombin III complexes,FPLX,000469,Thrombin_antithrombin +thrombospondin protein,FPLX,000467,THBS +Thrombospondin,FPLX,000467,THBS +thrombospondin,FPLX,000467,THBS +Thrombospondins,FPLX,000467,THBS +thrombospondins,FPLX,000467,THBS +thyroid hormone receptor,FPLX,000468,THR +TIAM,FPLX,000470,TIAM +TIAM1,UP,Q13009,TIAM1_HUMAN +Tiam1,UP,Q13009,TIAM1_HUMAN +TIAM2,UP,Q8IVF5,TIAM2_HUMAN +Tiam2,UP,Q8IVF5,TIAM2_HUMAN +TIF-IB,FPLX,000471,TIF_IB +tipifarnib,PUBCHEM,159324, +tipifarnib,CHEBI,CHEBI:141969,tipifarnib +tissue kallikrein,FPLX,000271,KLK +tissue kallikreins,FPLX,000271,KLK +TLR,FPLX,000472,TLR +TLR2,UP,O60603,TLR2_HUMAN +TLR4,UP,O00206,TLR4_HUMAN +TMZ,CHEBI,CHEBI:72564,temozolomide +TMZ,PUBCHEM,5394, +TN-C,FPLX,000478,Troponin_C +TnC,FPLX,000478,Troponin_C +TNF,UP,P01375,TNFA_HUMAN +TNF-alpha,UP,P01375,TNFA_HUMAN +TNF-R superfamily,FPLX,000475,TNFRSF +TNF-receptor family,FPLX,000475,TNFRSF +TNF-α,UP,P01375,TNFA_HUMAN +TNFalpha,UP,P01375,TNFA_HUMAN +TNFR family,FPLX,000475,TNFRSF +TNFR subfamily,FPLX,000475,TNFRSF +TNFR superfamily members,FPLX,000475,TNFRSF +TNFR superfamily receptors,FPLX,000475,TNFRSF +TNFR superfamily,FPLX,000475,TNFRSF +TNFR,FPLX,000475,TNFRSF +TNFR1,UP,P19438,TNR1A_HUMAN +TNFα,UP,P01375,TNFA_HUMAN +topoisomerase II,FPLX,000476,TOP2 +TORC1,FPLX,000293,mTORC1 +TORC2,FPLX,000294,mTORC2 +TP53,UP,P04637,P53_HUMAN +TPA,PUBCHEM,27924, +TPA,CHEBI,CHEBI:37537,phorbol 13-acetate 12-myristate +Tpl2,HGNC,6860,MAP3K8 +TPNI,FPLX,000479,Troponin_I +TPNT,FPLX,000480,Troponin_T +TQ,PUBCHEM,10281, +TQ,CHEBI,CHEBI:113532,"2-methyl-5-propan-2-ylcyclohexa-2,5-diene-1,4-dione" +TRAF2,UP,Q12933,TRAF2_HUMAN +TRAF3,UP,Q13114,TRAF3_HUMAN +TRAF6,UP,Q9Y4K3,TRAF6_HUMAN +TRAIL,UP,P50591,TNF10_HUMAN +trametinib,CHEBI,CHEBI:75998,trametinib +trametinib,PUBCHEM,11707110, +Transcription factor AP-2,FPLX,000463,TFAP2 +transcription factor AP-2,FPLX,000463,TFAP2 +transcription factor DP,FPLX,000464,TFDP +transcription factor II E,FPLX,000196,GTF2E +transcription factor II F,FPLX,000197,GTF2F +transcription factor IIE,FPLX,000196,GTF2E +transcription factor IIF,FPLX,000197,GTF2F +transcription,GO,GO:0006351,"transcription, DNA-templated" +transcription,MESH,D014158,"Transcription, Genetic" +transcriptional cofactor complex CRSP,FPLX,000122,CRSP +transforming growth factor beta,FPLX,000465,TGFB +transforming growth factor β,FPLX,000465,TGFB +transforming growth factor-beta,FPLX,000465,TGFB +transforming growth factor-β,FPLX,000465,TGFB +translation,GO,GO:0006412,translation +translation,MESH,D014176,Protein Biosynthesis +transport,GO,GO:0006810,transport +trastuzumab,MESH,D000068878,Trastuzumab +trastuzumab,CHEMBL,1201585, +TRiC,FPLX,000085,CCT_complex +TRIM,UP,Q6PIZ9,TRAT1_HUMAN +Trk receptor,FPLX,000321,NTRK +trk receptor,FPLX,000321,NTRK +Trk receptors,FPLX,000321,NTRK +trk receptors,FPLX,000321,NTRK +TrkA,UP,P04629,NTRK1_HUMAN +TrkB,UP,Q16620,NTRK2_HUMAN +troponin C,FPLX,000478,Troponin_C +troponin complex,FPLX,000477,Troponin +troponin I,FPLX,000479,Troponin_I +troponin T,FPLX,000480,Troponin_T +troponin,FPLX,000477,Troponin +troponins,FPLX,000477,Troponin +trypsin,CHEBI,CHEBI:9765,Trypsin +Tryptase,FPLX,000481,Tryptase +tryptase,FPLX,000481,Tryptase +tryptases,FPLX,000481,Tryptase +TSA,PUBCHEM,444732, +TSA,CHEBI,CHEBI:46024,trichostatin A +TSC,FPLX,000482,TSC +TSC1,UP,Q92574,TSC1_HUMAN +TSC2,UP,P49815,TSC2_HUMAN +TUBA,FPLX,000483,TUBA +TUBB,FPLX,000484,TUBB +tuberin,UP,P49815,TSC2_HUMAN +tubulin alpha chain,FPLX,000483,TUBA +tubulin beta chain,FPLX,000484,TUBB +tubulin beta,FPLX,000484,TUBB +tubulin delta,HGNC,16811,TUBD1 +tubulin epsilon,HGNC,20775,TUBE1 +tubulin gamma,FPLX,000485,TUBG +tubulin α chain,FPLX,000483,TUBA +tubulin β chain,FPLX,000484,TUBB +tubulin β,FPLX,000484,TUBB +tubulin γ,FPLX,000485,TUBG +tubulin δ,HGNC,16811,TUBD1 +tubulin ε,HGNC,20775,TUBE1 +tubulin,FPLX,000486,Tubulin +tumor necrosis factor,UP,P01375,TNFA_HUMAN +tumorigenesis,MESH,D063646,Carcinogenesis +tunicamycin,CHEBI,CHEBI:29699,tunicamycin +tunicamycin,PUBCHEM,56927680, +type 2 phosphatidic acid phosphatase,FPLX,000374,PPAP2 +type 2 phosphatidic acid phosphatases,FPLX,000374,PPAP2 +type 4 cyclic nucleotide phosphodiesterase,FPLX,000338,PDE4 +Type I collagen,FPLX,000109,COL1 +type I collagen,FPLX,000109,COL1 +type II phosphatidic acid phosphatase,FPLX,000374,PPAP2 +type II phosphatidic acid phosphatases,FPLX,000374,PPAP2 +type V collagen,FPLX,000111,COL5 +type-V collagen,FPLX,000111,COL5 +U0126,PUBCHEM,3006531, +U0126,CHEBI,CHEBI:90693,U0126 +Ub,FPLX,000490,Ubiquitin +ub,FPLX,000490,Ubiquitin +UBE2,FPLX,000489,UBE2 +ubiquitin conjugating enzyme,FPLX,000489,UBE2 +Ubiquitin,FPLX,000490,Ubiquitin +ubiquitin,FPLX,000490,Ubiquitin +ubiquitin-conjugating enzymes,FPLX,000489,UBE2 +UGT,FPLX,000492,UGT +uPA,UP,P00749,UROK_HUMAN +uPAR,UP,Q03405,UPAR_HUMAN +vascular endothelial growth factor,FPLX,000495,VEGF +VAV family,FPLX,000494,VAV +Vav,FPLX,000494,VAV +Vav1,UP,P15498,VAV_HUMAN +VCAM-1,UP,P19320,VCAM1_HUMAN +VEGF receptor,FPLX,000496,VEGFR +VEGF receptors,FPLX,000496,VEGFR +VEGF,FPLX,000495,VEGF +VEGF-A,UP,P15692,VEGFA_HUMAN +VEGFR ligand,FPLX,000496,VEGFR +VEGFR,FPLX,000496,VEGFR +VEGFR-2,UP,P35968,VGFR2_HUMAN +VEGFR2,UP,P35968,VGFR2_HUMAN +VEGFRs,FPLX,000496,VEGFR +Vemurafenib,PUBCHEM,42611257, +Vemurafenib,CHEBI,CHEBI:63637,vemurafenib +vemurafenib,PUBCHEM,42611257, +vemurafenib,CHEBI,CHEBI:63637,vemurafenib +vitronectin receptor (integrin),FPLX,000261,Integrins +VLDL,CHEBI,CHEBI:39027,very-low-density lipoprotein +vorinostat,PUBCHEM,5311, +vorinostat,CHEBI,CHEBI:45716,vorinostat +VPA,PUBCHEM,3121, +VPA,CHEBI,CHEBI:39867,valproic acid +Vpr,UP,P05928,VPR_HV1BR +Vpu,UP,P05919,VPU_HV1H2 +WA,PUBCHEM,265237, +WA,CHEBI,CHEBI:69120,withaferin A +wild type c-Cbl,UP,P22681,CBL_HUMAN +WNT,FPLX,000497,Wnt +Wnt,FPLX,000497,Wnt +Wnt5a,UP,P41221,WNT5A_HUMAN +wogonin,PUBCHEM,5281703, +wogonin,CHEBI,CHEBI:10043,wogonin +XIAP,UP,P98170,XIAP_HUMAN +XYLT,FPLX,000185,GCNT +Xylosyltransferase,FPLX,000185,GCNT +Xylosyltransferases,FPLX,000185,GCNT +xylosyltransferase,FPLX,000185,GCNT +xylosyltransferases,FPLX,000185,GCNT +Y box binding protein,FPLX,000498,YBX +Y-box-binding protein,FPLX,000498,YBX +YAP,UP,P46937,YAP1_HUMAN +YAP1,UP,P46937,YAP1_HUMAN +YBX protein family,FPLX,000498,YBX +ZEB1,UP,P37275,ZEB1_HUMAN +Zeb1,UP,P37275,ZEB1_HUMAN +β adrenergic receptor kinase,FPLX,000022,ADRBK +α catenin,FPLX,000126,CTNNA +β interferons,FPLX,000247,IFNB +γ secretase,FPLX,000181,Gamma_secretase +α tubulin,FPLX,000483,TUBA +γ tubulin,FPLX,000485,TUBG +α(2)-adrenoceptors,FPLX,000020,ADRA2 +α(2)-ARs,FPLX,000020,ADRA2 +α-adrenergic receptor,FPLX,000019,ADRA +β-adrenergic receptor,FPLX,000021,ADRB +α-adrenoreceptor,FPLX,000019,ADRA +β-adrenoreceptor,FPLX,000021,ADRB +α-adrenoreceptors,FPLX,000019,ADRA +γ-aminobutyric-acid A receptor,FPLX,000179,GABR +α-catenin,FPLX,000126,CTNNA +β-catenin,UP,P35222,CTNB1_HUMAN +β-TrCP,UP,Q9Y297,FBW1A_HUMAN +γ-tubulin,FPLX,000485,TUBG +δ-tubulin,HGNC,16811,TUBD1 +ε-tubulin,HGNC,20775,TUBE1 +α1β1γ1,FPLX,000032,AMPK_A1B1G1 +α1β1γ2,FPLX,000033,AMPK_A1B1G2 +α1β1γ3,FPLX,000034,AMPK_A1B1G3 +α1β2γ1,FPLX,000035,AMPK_A1B2G1 +α1β2γ2,FPLX,000036,AMPK_A1B2G2 +α2-AR,FPLX,000020,ADRA2 +α2β1γ1,FPLX,000038,AMPK_A2B1G1 +α2β2γ1,FPLX,000041,AMPK_A2B2G1 +α2β2γ2,FPLX,000042,AMPK_A2B2G2 +α2β2γ3,FPLX,000043,AMPK_A2B2G3 +βAR,FPLX,000021,ADRB +βARK,FPLX,000022,ADRBK +receptor,GO,GO:0038023,signaling receptor activity +eGFR,MESH,D005919,Glomerular Filtration Rate +CDK1/2,FPLX,000093,CDK1_2 +cdk1/2,FPLX,000093,CDK1_2 +Cdk1/2,FPLX,000093,CDK1_2 +Chk1/2,FPLX,000098,CHEK +chromosomal instability,MESH,D043171,Chromosomal Instability +chromosomal instability,NCIT,C48195, +chromosomal instabiliy,MESH,D043171,Chromosomal Instability +chromosomal instabiliy,NCIT,C48195, +CIN,MESH,D043171,Chromosomal Instability +CIN,NCIT,C48195, +CycK,HGNC,1596,CCNK +CycK1,HGNC,1596,CCNK +dinaciclib,PUBCHEM,46926350, +dinaciclib,CHEMBL,CHEMBL2103840, +dinaciclib,CHEBI,CHEBI:95060,"2-[(2S)-1-[3-ethyl-7-[(1-oxido-3-pyridin-1-iumyl)methylamino]-5-pyrazolo[1,5-a]pyrimidinyl]-2-piperidinyl]ethanol" +Dinaciclib,PUBCHEM,46926350, +Dinaciclib,CHEMBL,CHEMBL2103840, +Dinaciclib,CHEBI,CHEBI:95060,"2-[(2S)-1-[3-ethyl-7-[(1-oxido-3-pyridin-1-iumyl)methylamino]-5-pyrazolo[1,5-a]pyrimidinyl]-2-piperidinyl]ethanol" +Ebp1,HGNC,8550,PA2G4 +EBP1,HGNC,8550,PA2G4 +erbB,FPLX,000160,ERBB +Fer-1,PUBCHEM,4068248, +HK2,HGNC,4923,HK2 +NLE,CHEBI,CHEBI:38473,azadirachtin +PD-1,UP,Q15116,PDCD1_HUMAN +PD-1,HGNC,8760,PDCD1 +Se,PUBCHEM,6326970, +Se,CHEBI,CHEBI:27568,selenium atom +THZ531,PUBCHEM,118025540, +THZ531,CHEBI,CHEBI:143122,THZ531 +Hh,FPLX,000226,Hedgehog +SIK,FPLX,000433,SIK +salt inducible kinase,FPLX,000433,SIK +Sik,UP,Q64434,PTK6_MOUSE +DYRK,FPLX,000146,DYRK +Augmin,FPLX,000061,Augmin +HAUS,FPLX,000061,Augmin +HAUS complex,FPLX,000061,Augmin +CRTC,FPLX,000123,CRTC diff --git a/famplex/resources/grounding_map.tsv b/famplex/resources/grounding_map.tsv deleted file mode 100644 index 8c370144e..000000000 --- a/famplex/resources/grounding_map.tsv +++ /dev/null @@ -1,2834 +0,0 @@ -AMPK (alpha 1, beta 1, gamma 1) FPLX 000032 AMPK_A1B1G1 -AMPK (alpha 1, beta 1, gamma 2) FPLX 000033 AMPK_A1B1G2 -AMPK (alpha 1, beta 1, gamma 3) FPLX 000034 AMPK_A1B1G3 -AMPK (alpha 1, beta 2, gamma 1) FPLX 000035 AMPK_A1B2G1 -AMPK (alpha 1, beta 2, gamma 2) FPLX 000036 AMPK_A1B2G2 -AMPK (alpha 1, beta 2, gamma 3) FPLX 000037 AMPK_A1B2G3 -AMPK (alpha 2, beta 1, gamma 1) FPLX 000038 AMPK_A2B1G1 -AMPK (alpha 2, beta 1, gamma 2) FPLX 000039 AMPK_A2B1G2 -AMPK (alpha 2, beta 1, gamma 3) FPLX 000040 AMPK_A2B1G3 -AMPK (alpha 2, beta 2, gamma 1) FPLX 000041 AMPK_A2B2G1 -AMPK (alpha 2, beta 2, gamma 2) FPLX 000042 AMPK_A2B2G2 -AMPK (alpha 2, beta 2, gamma 3) FPLX 000043 AMPK_A2B2G3 -AMPK (α 1, β 1, γ 1) FPLX 000032 AMPK_A1B1G1 -AMPK (α 1, β 1, γ 2) FPLX 000033 AMPK_A1B1G2 -AMPK (α 1, β 1, γ 3) FPLX 000034 AMPK_A1B1G3 -AMPK (α 1, β 2, γ 1) FPLX 000035 AMPK_A1B2G1 -AMPK (α 1, β 2, γ 2) FPLX 000036 AMPK_A1B2G2 -AMPK (α 1, β 2, γ 3) FPLX 000037 AMPK_A1B2G3 -AMPK (α 2, β 1, γ 1) FPLX 000038 AMPK_A2B1G1 -AMPK (α 2, β 1, γ 2) FPLX 000039 AMPK_A2B1G2 -AMPK (α 2, β 1, γ 3) FPLX 000040 AMPK_A2B1G3 -AMPK (α 2, β 2, γ 1) FPLX 000041 AMPK_A2B2G1 -AMPK (α 2, β 2, γ 2) FPLX 000042 AMPK_A2B2G2 -AMPK (α 2, β 2, γ 3) FPLX 000043 AMPK_A2B2G3 -Glutamate receptors, ionotropic, kainate FPLX 000269 Kainate_family -Na(+),K(+)-ATPase FPLX 000303 Na_K_ATPase -Na,K-ATPase beta subunit FPLX 000058 ATP1B -Na,K-ATPase β subunit FPLX 000058 ATP1B -Na,K-ATPase FPLX 000303 Na_K_ATPase -(9-1-1) complex FPLX 000001 9_1_1 -14-3-3 proteins FPLX 000323 p14_3_3 -14-3-3 FPLX 000323 p14_3_3 -14-3-3zeta UP P63104 1433Z_HUMAN -4E-BP1 UP Q13541 4EBP1_HUMAN -4EBP FPLX 000154 EIF4EBP -4EBP1 UP Q13541 4EBP1_HUMAN -53BP1 UP Q12888 TP53B_HUMAN -9-1-1 complex FPLX 000001 9_1_1 -9-1-1 FPLX 000001 9_1_1 -a-adrenoreceptor FPLX 000019 ADRA -a-cathenin FPLX 000126 CTNNA -A2t FPLX 000047 Annexin_II_heterotetramer -ABA PUBCHEM 5280896 . -ABA CHEBI CHEBI:2365 (+)-abscisic acid -Abeta UP P05067 A4_HUMAN -Abeta CHEBI CHEBI:64645 amyloid-beta -Abi1 UP Q8IZP0 ABI1_HUMAN -ABL family FPLX 000003 ABL_family -ABL FPLX 000003 ABL_family -Abl UP P00519 ABL1_HUMAN -AC MESH D000230 Adenocarcinoma -AC UP Q08828 ADCY1_HUMAN -ACAD FPLX 000004 ACAD -ACC FPLX 000005 ACC -ACCs FPLX 000005 ACC -Acetate-CoA ligase FPLX 000006 Acetyl_CoA_synthetase -acetyl CoA ligase FPLX 000006 Acetyl_CoA_synthetase -acetyl CoA synthase FPLX 000006 Acetyl_CoA_synthetase -Acetyl Coenzyme A Carboxylase FPLX 000005 ACC -Acetyl-CoA carboxylase FPLX 000005 ACC -acetyl-CoA carboxylase FPLX 000005 ACC -Acetyl-CoA synthetase FPLX 000006 Acetyl_CoA_synthetase -acetyl-CoA synthetase FPLX 000006 Acetyl_CoA_synthetase -acetyl-coenzyme A synthase FPLX 000006 Acetyl_CoA_synthetase -acetylcholine receptor FPLX 000102 CHRM -Ack1 UP Q07912 ACK1_HUMAN -ACS FPLX 000006 Acetyl_CoA_synthetase -Acsl FPLX 000008 ACSL -actin filament FPLX 000009 Actin -actin FPLX 000009 Actin -actinin FPLX 000014 ACTN -actins FPLX 000009 Actin -Activin A protein FPLX 000011 Activin_A -Activin A FPLX 000011 Activin_A -activin A FPLX 000011 Activin_A -activin AB FPLX 000012 Activin_AB -activin protein FPLX 000010 Activin -Activin FPLX 000010 Activin -activin FPLX 000010 Activin -activin-A FPLX 000011 Activin_A -activin-B FPLX 000013 Activin_B -activinA FPLX 000011 Activin_A -activins FPLX 000010 Activin -acyl CoA dehydrogenase FPLX 000004 ACAD -acyl-CoA dehydrogenase FPLX 000004 ACAD -Acyl-CoA Oxidase FPLX 000007 ACOX -acyl-CoA oxidases FPLX 000007 ACOX -Adaptor Protein 2 complex FPLX 000015 Adaptor_protein_II -adaptor protein complex 2 FPLX 000015 Adaptor_protein_II -adaptor protein complex 3 FPLX 000016 Adaptor_protein_III -adenylate cyclase FPLX 000017 ADCY -adenylyl cyclase FPLX 000017 ADCY -adhesion GO GO:0007155 cell adhesion -adhesion MESH D002448 Cell Adhesion -adiponectin UP Q15848 ADIPO_HUMAN -ADP CHEBI CHEBI:16761 ADP -ADP PUBCHEM 6022 . -ADP ribosylation factor FPLX 000053 ARF_GTPase_family -afatinib PUBCHEM 10184653 . -afatinib LINCS 10133-101 . -afatinib CHEBI CHEBI:61390 afatinib -AHR UP P35869 AHR_HUMAN -AICAR PUBCHEM 65110 . -AICAR CHEBI CHEBI:18406 AICA ribonucleotide -AKT family FPLX 000023 AKT -AKT FPLX 000023 AKT -Akt FPLX 000023 AKT -AKT1 UP P31749 AKT1_HUMAN -Akt1 UP P31749 AKT1_HUMAN -AKT2 UP P31751 AKT2_HUMAN -Akt2 UP P31751 AKT2_HUMAN -alcohol dehydrogenase FPLX 000018 ADH -alcohol PUBCHEM 702 . -alcohol CHEBI CHEBI:16236 ethanol -alcohol HMDB HMDB00108 . -aldehyde dehydrogenase (NAD+) FPLX 000024 ALDH -Aldehyde dehydrogenase FPLX 000024 ALDH -aldehyde dehydrogenase FPLX 000024 ALDH -ALDH FPLX 000024 ALDH -ALDO FPLX 000025 ALDO -aldosterone CHEBI CHEBI:27584 aldosterone -aldosterone PUBCHEM 5839 . -ALG10 FPLX 000026 ALG10 -ALIX HGNC 8766 PDCD6IP -ALIX UP Q8WUM4 PDC6I_HUMAN -ALK UP Q9UM73 ALK_HUMAN -alkali myosin light chains FPLX 000297 MYL_alkali -alpha adrenoceptor FPLX 000019 ADRA -alpha catenin FPLX 000126 CTNNA -alpha tubulin FPLX 000483 TUBA -alpha(2)-adrenoceptors FPLX 000020 ADRA2 -alpha(2)-ARs FPLX 000020 ADRA2 -alpha-adrenergic receptor FPLX 000019 ADRA -alpha-adrenoreceptor FPLX 000019 ADRA -alpha-adrenoreceptors FPLX 000019 ADRA -alpha-catenin FPLX 000126 CTNNA -alpha1 adrenoceptor FPLX 000019 ADRA -Alpha-1,2-glucosyltransferase FPLX 000026 ALG10 -Alpha-1,2-glucosyltransferases FPLX 000026 ALG10 -alpha-1,2-glucosyltransferase FPLX 000026 ALG10 -alpha-1,2-glucosyltransferases FPLX 000026 ALG10 -Alpha-1,3-glucosyltransferase FPLX 000029 ALG6_family -Alpha-1,3-glucosyltransferases FPLX 000029 ALG6_family -alpha-1,3-glucosyltransferase FPLX 000029 ALG6_family -alpha-1,3-glucosyltransferases FPLX 000029 ALG6_family -Alpha-1,4-glucosyltransferase FPLX 000029 ALG6_family -Alpha-1,4-glucosyltransferases FPLX 000029 ALG6_family -alpha-1,4-glucosyltransferase FPLX 000029 ALG6_family -alpha-1,4-glucosyltransferases FPLX 000029 ALG6_family -alpha1beta1gamma1 FPLX 000032 AMPK_A1B1G1 -alpha1beta1gamma2 FPLX 000033 AMPK_A1B1G2 -alpha1beta1gamma3 FPLX 000034 AMPK_A1B1G3 -alpha1beta2gamma1 FPLX 000035 AMPK_A1B2G1 -alpha1beta2gamma2 FPLX 000036 AMPK_A1B2G2 -alpha2 adrenoceptor FPLX 000020 ADRA2 -alpha2-AR FPLX 000020 ADRA2 -alpha2beta1 integrin FPLX 000261 Integrins -alpha2beta1gamma1 FPLX 000038 AMPK_A2B1G1 -alpha2beta2gamma1 FPLX 000041 AMPK_A2B2G1 -alpha2beta2gamma2 FPLX 000042 AMPK_A2B2G2 -alpha2beta2gamma3 FPLX 000043 AMPK_A2B2G3 -ALS UP P35858 ALS_HUMAN -AM HGNC 259 ADM -AM UP P35318 ADML_HUMAN -AM MESH D000650 Amnion -AMG655 MESH C554537 conatumumab -AMLC FPLX 000297 MYL_alkali -AMP HMDB HMDB00045 . -AMP CHEBI CHEBI:16027 adenosine 5'-monophosphate -AMP PUBCHEM 6083 . -AMPA glutamate receptor FPLX 000191 GRIA -AMPA receptor FPLX 000191 GRIA -AMPA-R FPLX 000191 GRIA -AMPA-subtype ionotropic glutamate receptors FPLX 000191 GRIA -AMPAR FPLX 000191 GRIA -AMPARs FPLX 000191 GRIA -AMPK (A1/B1/G1) FPLX 000032 AMPK_A1B1G1 -AMPK (A1/B1/G2) FPLX 000033 AMPK_A1B1G2 -AMPK (A1/B1/G3) FPLX 000034 AMPK_A1B1G3 -AMPK (A1/B2/G1) FPLX 000035 AMPK_A1B2G1 -AMPK (A1/B2/G2) FPLX 000036 AMPK_A1B2G2 -AMPK (A1/B2/G3) FPLX 000037 AMPK_A1B2G3 -AMPK (A2/B1/G1) FPLX 000038 AMPK_A2B1G1 -AMPK (A2/B1/G2) FPLX 000039 AMPK_A2B1G2 -AMPK (A2/B1/G3) FPLX 000040 AMPK_A2B1G3 -AMPK (A2/B2/G1) FPLX 000041 AMPK_A2B2G1 -AMPK (A2/B2/G2) FPLX 000042 AMPK_A2B2G2 -AMPK (A2/B2/G3) FPLX 000043 AMPK_A2B2G3 -AMPK a1b1g1 FPLX 000032 AMPK_A1B1G1 -AMPK a1b1g2 FPLX 000033 AMPK_A1B1G2 -AMPK a1b1g3 FPLX 000034 AMPK_A1B1G3 -AMPK a1b2g1 FPLX 000035 AMPK_A1B2G1 -AMPK a1b2g2 FPLX 000036 AMPK_A1B2G2 -AMPK a2b1g1 FPLX 000038 AMPK_A2B1G1 -AMPK a2b2g1 FPLX 000041 AMPK_A2B2G1 -AMPK a2b2g2 FPLX 000042 AMPK_A2B2G2 -AMPK a2b2g3 FPLX 000043 AMPK_A2B2G3 -AMPK alpha1beta1gamma1 FPLX 000032 AMPK_A1B1G1 -AMPK alpha1beta1gamma2 FPLX 000033 AMPK_A1B1G2 -AMPK alpha1beta1gamma3 FPLX 000034 AMPK_A1B1G3 -AMPK alpha1beta2gamma1 FPLX 000035 AMPK_A1B2G1 -AMPK alpha1beta2gamma2 FPLX 000036 AMPK_A1B2G2 -AMPK alpha1beta2gamma3 FPLX 000037 AMPK_A1B2G3 -AMPK alpha2beta1gamma1 FPLX 000038 AMPK_A2B1G1 -AMPK alpha2beta1gamma2 FPLX 000039 AMPK_A2B1G2 -AMPK alpha2beta1gamma3 FPLX 000040 AMPK_A2B1G3 -AMPK alpha2beta2gamma1 FPLX 000041 AMPK_A2B2G1 -AMPK alpha2beta2gamma2 FPLX 000042 AMPK_A2B2G2 -AMPK alpha2beta2gamma3 FPLX 000043 AMPK_A2B2G3 -AMPK α1β1γ1 FPLX 000032 AMPK_A1B1G1 -AMPK α1β1γ2 FPLX 000033 AMPK_A1B1G2 -AMPK α1β1γ3 FPLX 000034 AMPK_A1B1G3 -AMPK α1β2γ1 FPLX 000035 AMPK_A1B2G1 -AMPK α1β2γ2 FPLX 000036 AMPK_A1B2G2 -AMPK α1β2γ3 FPLX 000037 AMPK_A1B2G3 -AMPK α2β1γ1 FPLX 000038 AMPK_A2B1G1 -AMPK α2β1γ2 FPLX 000039 AMPK_A2B1G2 -AMPK α2β1γ3 FPLX 000040 AMPK_A2B1G3 -AMPK α2β2γ1 FPLX 000041 AMPK_A2B2G1 -AMPK α2β2γ2 FPLX 000042 AMPK_A2B2G2 -AMPK α2β2γ3 FPLX 000043 AMPK_A2B2G3 -AMPK FPLX 000031 AMPK -AMPK-alpha1 UP Q13131 AAPK1_HUMAN -AMPK-alpha2 UP P54646 AAPK2_HUMAN -AMPK-α1 UP Q13131 AAPK1_HUMAN -AMPK-α2 UP P54646 AAPK2_HUMAN -AMPKalpha FPLX 000044 AMPK_alpha -AMPKalpha1 catalytic domain UP Q13131 AAPK1_HUMAN -AMPKalpha1 UP Q13131 AAPK1_HUMAN -AMPKα FPLX 000044 AMPK_alpha -AMPKα1 catalytic domain UP Q13131 AAPK1_HUMAN -AMPKα1 UP Q13131 AAPK1_HUMAN -amyloid beta UP P05067 A4_HUMAN -amyloid beta CHEBI CHEBI:64645 amyloid-beta -amyloid β UP P05067 A4_HUMAN -amyloid β CHEBI CHEBI:64645 amyloid-beta -Ang II UP P01019 ANGT_HUMAN -AngII UP P01019 ANGT_HUMAN -angiogenesis GO GO:0001525 angiogenesis -angiogenesis MESH D018919 Neovascularization, Physiologic -annexin A2 heterotetramer FPLX 000047 Annexin_II_heterotetramer -annexin II heterotetramer FPLX 000047 Annexin_II_heterotetramer -ANXA2 heterotetramer FPLX 000047 Annexin_II_heterotetramer -AP-1 FPLX 000048 AP1 -AP-2 adaptor complex FPLX 000015 Adaptor_protein_II -AP-2 complex FPLX 000015 Adaptor_protein_II -AP-2 transcription factor FPLX 000463 TFAP2 -AP-2 FPLX 000015 Adaptor_protein_II -AP-3 FPLX 000016 Adaptor_protein_III -AP1 FPLX 000048 AP1 -AP2 adaptor complex FPLX 000015 Adaptor_protein_II -AP2 clathrin adaptor complex FPLX 000015 Adaptor_protein_II -AP2 complex FPLX 000015 Adaptor_protein_II -AP2 FPLX 000015 Adaptor_protein_II -AP3 FPLX 000016 Adaptor_protein_III -Apaf-1 UP O14727 APAF_HUMAN -APC UP P25054 APC_HUMAN -APC/C FPLX 000050 APC_C -apigenin CHEBI CHEBI:18388 apigenin -apigenin PUBCHEM 5280443 . -ApoA FPLX 000051 APOA -apoA FPLX 000051 APOA -apocynin CHEBI CHEBI:2781 apocynin -apocynin PUBCHEM 2214 . -apolipoprotein (a) FPLX 000051 APOA -apolipoprotein A FPLX 000051 APOA -apolipoprotein(A) FPLX 000051 APOA -apolipoprotein(a) FPLX 000051 APOA -Apolipoprotein FPLX 000052 Apolipoprotein -apolipoprotein FPLX 000052 Apolipoprotein -apolipoproteins FPLX 000052 Apolipoprotein -Apoptosis GO GO:0006915 apoptotic process -Apoptosis MESH D017209 Apoptosis -apoptosis GO GO:0006915 apoptotic process -apoptosis MESH D017209 Apoptosis -AR UP P10275 ANDR_HUMAN -ARF FPLX 000053 ARF_GTPase_family -ARF UP Q8N726 ARF_HUMAN -Arf UP Q8N726 ARF_HUMAN -Arp2/3 FPLX 000054 Arp2_3_protein -Arsenic trioxide CHEBI CHEBI:30621 diarsenic trioxide -Arsenic trioxide PUBCHEM 518605 . -arsenic PUBCHEM 5359596 . -arsenic CHEBI CHEBI:27563 arsenic atom -arsenite CHEBI CHEBI:29866 arsenite(3-) -arsenite PUBCHEM 544 . -artemisinin CHEBI CHEBI:223316 (+)-artemisinin -artemisinin PUBCHEM 68827 . -ASK1 UP Q99683 M3K5_HUMAN -aspirin PUBCHEM 2244 . -aspirin CHEBI CHEBI:15365 acetylsalicylic acid -ASPP1 UP Q96KQ4 ASPP1_HUMAN -ASPP2 UP Q13625 ASPP2_HUMAN -ATF2 UP P15336 ATF2_HUMAN -ATG4 FPLX 000056 ATG4 -Atg4 FPLX 000056 ATG4 -ATM UP Q13315 ATM_HUMAN -ATP synthase H + transporting mitochondrial F0 complex subunit G FPLX 000059 ATP5G -ATP synthase FPLX 000060 ATP_synthase -ATP HMDB HMDB00538 . -ATP PUBCHEM 5957 . -ATP CHEBI CHEBI:15422 ATP -ATP1A FPLX 000057 ATP1A -ATP1B FPLX 000058 ATP1B -ATPase Na+/K+ transporting subunit alpha FPLX 000057 ATP1A -ATPase Na+/K+ transporting subunit beta FPLX 000057 ATP1A -ATPase Na+/K+ transporting subunit α FPLX 000057 ATP1A -ATPase Na+/K+ transporting subunit β FPLX 000057 ATP1A -ATR UP Q13535 ATR_HUMAN -ATRA CHEBI CHEBI:15367 all-trans-retinoic acid -ATRA PUBCHEM 444795 . -autophagic cell death GO GO:0048102 autophagic cell death -Autophagy GO GO:0006914 autophagy -Autophagy MESH D001343 Autophagy -autophagy GO GO:0006914 autophagy -autophagy MESH D001343 Autophagy -Axin FPLX 000062 AXIN -AZD6244 CHEBI CHEBI:90227 selumetinib -AZD6244 PUBCHEM 10127622 . -Aβ UP P05067 A4_HUMAN -Aβ CHEBI CHEBI:64645 amyloid-beta -B3GAT FPLX 000063 B3GAT -b-adrenergic receptor FPLX 000021 ADRB -b-arrestin FPLX 000055 ARRB -B-Raf UP P15056 BRAF_HUMAN -b-receptors FPLX 000021 ADRB -B1 UP O43157 PLXB1_HUMAN -B1 UP P14635 CCNB1_HUMAN -BAD UP Q92934 BAD_HUMAN -Bad UP Q92934 BAD_HUMAN -Bak UP Q16611 BAK_HUMAN -Bam32 UP Q9UN19 DAPP1_HUMAN -BARK FPLX 000022 ADRBK -barrestins FPLX 000055 ARRB -BAX UP Q07812 BAX_HUMAN -Bax UP Q07812 BAX_HUMAN -BCKDC FPLX 000064 BCKDC -BCKDH FPLX 000064 BCKDC -BCL-2 UP P10415 BCL2_HUMAN -Bcl-2 UP P10415 BCL2_HUMAN -bcl-2 UP P10415 BCL2_HUMAN -Bcl-3 HGNC 998 BCL3 -Bcl-xL UP Q07817 B2CL1_HUMAN -BCL2 UP P10415 BCL2_HUMAN -Bcl2 UP P10415 BCL2_HUMAN -BCR UP P11274 BCR_HUMAN -Beclin-1 UP Q14457 BECN1_HUMAN -berberine CHEBI CHEBI:16118 berberine -berberine PUBCHEM 2353 . -Beta-1,3-glucuronyltransferase FPLX 000063 B3GAT -Beta-1,3-glucuronyltransferases FPLX 000063 B3GAT -beta-1,3-glucuronyltransferase FPLX 000063 B3GAT -beta-1,3-glucuronyltransferases FPLX 000063 B3GAT -Beta 3-glycosyltransferase FPLX 000065 Beta_3_4_GTF -Beta 3-glycosyltransferases FPLX 000065 Beta_3_4_GTF -beta 3-glycosyltransferase FPLX 000065 Beta_3_4_GTF -beta 3-glycosyltransferases FPLX 000065 Beta_3_4_GTF -Beta 4-glycosyltransferase FPLX 000065 Beta_3_4_GTF -Beta 4-glycosyltransferases FPLX 000065 Beta_3_4_GTF -beta 4-glycosyltransferase FPLX 000065 Beta_3_4_GTF -beta 4-glycosyltransferases FPLX 000065 Beta_3_4_GTF -beta adrenergic receptor kinase FPLX 000022 ADRBK -beta interferons FPLX 000247 IFNB -Beta Tubulin FPLX 000484 TUBB -Beta tubulin FPLX 000484 TUBB -beta Tubulin FPLX 000484 TUBB -beta tubulin FPLX 000484 TUBB -beta-adrenergic receptor FPLX 000021 ADRB -beta-adrenoreceptor FPLX 000021 ADRB -beta-catenin UP P35222 CTNB1_HUMAN -beta-TrCP UP Q9Y297 FBW1A_HUMAN -Beta-Tubulin FPLX 000484 TUBB -Beta-tubulin FPLX 000484 TUBB -beta-Tubulin FPLX 000484 TUBB -beta-tubulin FPLX 000484 TUBB -betaAR FPLX 000021 ADRB -betaARK FPLX 000022 ADRBK -BEZ235 PUBCHEM 11977753 . -BEZ235 CHEBI CHEBI:71952 dactolisib -bFGF UP P09038 FGF2_HUMAN -Bid UP P55957 BID_HUMAN -BIM UP O43521 B2L11_HUMAN -Bim UP O43521 B2L11_HUMAN -biosynthesis GO GO:0009058 biosynthetic process -BIRs FPLX 000066 BIRC -BITC PUBCHEM 2346 . -BITC CHEBI CHEBI:17484 benzyl isothiocyanate -BMF UP Q96LC9 BMF_HUMAN -BMI1 UP P35226 BMI1_HUMAN -BMP Receptor Type I FPLX 000069 BMP_receptor_type_I -BMP Receptor Type II FPLX 000070 BMP_receptor_type_II -BMP type I receptor FPLX 000069 BMP_receptor_type_I -BMP type II receptor FPLX 000070 BMP_receptor_type_II -BMP FPLX 000067 BMP -BMP9 UP Q9UK05 GDF2_HUMAN -bone morphogenetic protein I receptor FPLX 000069 BMP_receptor_type_I -bone morphogenetic protein receptor 1 FPLX 000069 BMP_receptor_type_I -bone morphogenetic protein receptor 2 FPLX 000070 BMP_receptor_type_II -bone morphogenetic protein receptor type I FPLX 000069 BMP_receptor_type_I -bone morphogenetic protein receptor type II FPLX 000070 BMP_receptor_type_II -bone morphogenetic protein type I receptors FPLX 000069 BMP_receptor_type_I -bone morphogenetic protein type II receptors FPLX 000070 BMP_receptor_type_II -bortezomib CHEBI CHEBI:52717 bortezomib -bortezomib PUBCHEM 387447 . -BPA CHEBI CHEBI:33216 bisphenol A -BPA PUBCHEM 6623 . -BRAF UP P15056 BRAF_HUMAN -branched-chain alpha-keto acid dehydrogenase complex FPLX 000064 BCKDC -branched-chain alpha-ketoacid dehydrogenase complex FPLX 000064 BCKDC -branched-chain α-keto acid dehydrogenase complex FPLX 000064 BCKDC -branched-chain α-ketoacid dehydrogenase complex FPLX 000064 BCKDC -BRCA FPLX 000071 BRCA -BRCA1 UP P38398 BRCA1_HUMAN -BRCA2 UP P51587 BRCA2_HUMAN -BRI FPLX 000069 BMP_receptor_type_I -BRII FPLX 000070 BMP_receptor_type_II -BRSK1 UP Q8TDC3 BRSK1_HUMAN -BRSK2 UP Q8IWQ3 BRSK2_HUMAN -Bub1 UP O43683 BUB1_HUMAN -BubR1 UP O60566 BUB1B_HUMAN -butein CHEBI CHEBI:3237 butein -butein PUBCHEM 5281222 . -c-Abl Kinase UP P00519 ABL1_HUMAN -c-Abl UP P00519 ABL1_HUMAN -c-Cbl protein UP P22681 CBL_HUMAN -c-Cbl UP P22681 CBL_HUMAN -c-FLIP UP O15519 CFLAR_HUMAN -c-Fos UP P01100 FOS_HUMAN -c-fos UP P01100 FOS_HUMAN -c-JNK FPLX 000267 JNK -c-Jun N-terminal kinase FPLX 000267 JNK -c-Jun NH2-terminal kinase FPLX 000267 JNK -c-Jun UP P05412 JUN_HUMAN -c-jun UP P05412 JUN_HUMAN -C-MAF UP O75444 MAF_HUMAN -c-MAF UP O75444 MAF_HUMAN -c-Maf UP O75444 MAF_HUMAN -c-maf UP O75444 MAF_HUMAN -c-MET HGNC 7029 MET -c-met HGNC 7029 MET -c-Met UP P08581 MET_HUMAN -c-Myb UP P10242 MYB_HUMAN -c-myc oncogene UP P01106 MYC_HUMAN -c-myc proteins UP P01106 MYC_HUMAN -c-MYC UP P01106 MYC_HUMAN -c-Myc UP P01106 MYC_HUMAN -c-myc UP P01106 MYC_HUMAN -C-PARP UP P09874 PARP1_HUMAN -c-Raf UP P04049 RAF1_HUMAN -c-Rel HGNC 9954 REL -c-src HGNC 11283 SRC -c-Src UP P12931 SRC_HUMAN -C/EBP FPLX 000097 CEBP -C/EBPalpha UP P49715 CEBPA_HUMAN -C/EBPbeta UP P17676 CEBPB_HUMAN -C/EBPβ UP P17676 CEBPB_HUMAN -C/EBPα UP P49715 CEBPA_HUMAN -c1 complex FPLX 000072 C1 -C1 FPLX 000072 C1 -C1-complex FPLX 000072 C1 -C1q FPLX 000073 C1q -Ca(2+)-calmodulin-dependent protein kinase II FPLX 000077 CAMK2_complex -Ca(2+)/calmodulin-dependent kinase II FPLX 000077 CAMK2_complex -Ca HMDB HMDB00464 . -Ca CHEBI CHEBI:29108 calcium(2+) -Ca PUBCHEM 271 . -cadherin FPLX 000074 Cadherin -caffeine PUBCHEM 2519 . -caffeine CHEBI CHEBI:27732 caffeine -Calcineurin catalytic subunit FPLX 000384 PPP3C -Calcineurin regulatory subunit FPLX 000385 PPP3R -calcineurin FPLX 000383 PPP3 -calcium HMDB HMDB00464 . -calcium CHEBI CHEBI:29108 calcium(2+) -calcium PUBCHEM 271 . -Calmodulin FPLX 000075 CALM -calmodulin FPLX 000075 CALM -calmodulindependent kinase II FPLX 000078 CAMK2_family -calpain FPLX 000079 CAPN -CaM kinase II FPLX 000077 CAMK2_complex -CaM FPLX 000075 CALM -CaMK family FPLX 000076 CAMK -CaMK II FPLX 000077 CAMK2_complex -CaMK FPLX 000076 CAMK -CAMK2 FPLX 000078 CAMK2_family -CaMK2 FPLX 000078 CAMK2_family -CaMKII FPLX 000077 CAMK2_complex -CAMKII FPLX 000078 CAMK2_family -cAMP PUBCHEM 6076 . -cAMP CHEBI CHEBI:17489 3',5'-cyclic AMP -cAMP HMDB HMDB00058 . -cAMP-dependent PK FPLX 000363 PKA -cAMP-dependent protein kinase FPLX 000363 PKA -CaN FPLX 000383 PPP3 -CAP23 UP P80723 BASP1_HUMAN -CAPE PUBCHEM 5281787 . -CAPE CHEBI CHEBI:8062 phenethyl caffeate -capsaicin PUBCHEM 1548943 . -capsaicin CHEBI CHEBI:3374 capsaicin -carboxylesterase FPLX 000080 Carboxylesterase -carboxylesterases FPLX 000080 Carboxylesterase -CARP-1 UP Q8IX12 CCAR1_HUMAN -Cas UP P56945 BCAR1_HUMAN -Casein kinase 1 FPLX 000124 CSNK1 -casein kinase 1 FPLX 000124 CSNK1 -casein kinase 2 FPLX 000104 CK2 -casein kinase I FPLX 000124 CSNK1 -casein kinase II complex FPLX 000104 CK2 -casein kinase II FPLX 000104 CK2 -caspase 3 UP P42574 CASP3_HUMAN -caspase 8 UP Q14790 CASP8_HUMAN -caspase FPLX 000081 Caspase -caspase-1 UP P29466 CASP1_HUMAN -Caspase-3 UP P42574 CASP3_HUMAN -caspase-3 UP P42574 CASP3_HUMAN -caspase-3/7 FPLX 000082 Caspase_3_7 -caspase-8 UP Q14790 CASP8_HUMAN -caspase-9 UP P55211 CASP9_HUMAN -caspases FPLX 000081 Caspase -catalase UP P04040 CATA_HUMAN -catalytic subunit of calcineurin FPLX 000384 PPP3C -catenin alpha FPLX 000126 CTNNA -catenin α FPLX 000126 CTNNA -Caveolin FPLX 000083 CAV -caveolin FPLX 000083 CAV -caveolin-1 UP Q03135 CAV1_HUMAN -CBF3 complex FPLX 000084 CBF3 -CBF3 FPLX 000084 CBF3 -Cbl UP P22681 CBL_HUMAN -Cbl-b UP Q13191 CBLB_HUMAN -CBP UP Q92793 CBP_HUMAN -Cby UP Q9Y3M2 CBY1_HUMAN -CCAAT/enhancer binding protein FPLX 000097 CEBP -CCN2 UP P29279 CTGF_HUMAN -CCND1 UP P24385 CCND1_HUMAN -CCT complex FPLX 000085 CCT_complex -CCT FPLX 000085 CCT_complex -Cd PUBCHEM 23973 . -Cd CHEBI CHEBI:22977 cadmium atom -CD16 FPLX 000086 CD16 -CD24 UP P25063 CD24_HUMAN -CD28 UP P10747 CD28_HUMAN -CD3 FPLX 000087 CD3 -CD32 FPLX 000088 CD32 -CD4 UP P01730 CD4_HUMAN -CD44 UP P16070 CD44_HUMAN -CD64 FPLX 000089 CD64 -CD8 FPLX 000090 CD8 -CD95 UP P25445 TNR6_HUMAN -Cdc20 UP Q12834 CDC20_HUMAN -CDC25 family FPLX 000091 CDC25 -Cdc25 phosphatases FPLX 000091 CDC25 -CDC25 FPLX 000091 CDC25 -Cdc25 FPLX 000091 CDC25 -CDC42 UP P60953 CDC42_HUMAN -Cdc42 UP P60953 CDC42_HUMAN -Cdc6 UP Q99741 CDC6_HUMAN -CDDP CHEBI CHEBI:27899 cisplatin -CDDP PUBCHEM 441203 . -CDK FPLX 000092 CDK -Cdk FPLX 000092 CDK -CDK1 UP P06493 CDK1_HUMAN -Cdk1 UP P06493 CDK1_HUMAN -CDK2 UP P24941 CDK2_HUMAN -Cdk2 UP P24941 CDK2_HUMAN -cdk2 UP P24941 CDK2_HUMAN -CDK4 UP P11802 CDK4_HUMAN -Cdk4 UP P11802 CDK4_HUMAN -CDK6 UP Q00534 CDK6_HUMAN -CDK8 UP P49336 CDK8_HUMAN -CDK9 UP P50750 CDK9_HUMAN -CDKN FPLX 000094 CDKN -CDKN1 FPLX 000095 CDKN1 -CDKN1A UP P38936 CDN1A_HUMAN -CDKN2 FPLX 000096 CDKN2 -CDKs FPLX 000092 CDK -celecoxib PUBCHEM 2662 . -celecoxib CHEBI CHEBI:41423 celecoxib -cell adhesion GO GO:0007155 cell adhesion -cell adhesion MESH D002448 Cell Adhesion -cell cycle GO GO:0007049 cell cycle -cell cycle MESH D002453 Cell Cycle -cell death GO GO:0008219 cell death -cell death MESH D016923 Cell Death -cell growth GO GO:0016049 cell growth -cell growth MESH D048708 Cell Growth Processes -cell migration GO GO:0016477 cell migration -cell migration MESH D002465 Cell Movement -cell migration NCIT C26169 . -cell motility GO GO:0016477 cell migration -cell motility MESH D002465 Cell Movement -cell motility NCIT C16404 . -cell motility GO GO:0048870 cell motility -cell proliferation GO GO:0008283 cell population proliferation -cell proliferation MESH D049109 Cell Proliferation -cell survival MESH D002470 Cell Survival -cell viability MESH D002470 Cell Survival -cellular senescence GO GO:0090398 cellular senescence -cellular senescence MESH D016922 Cellular Senescence -ceramide CHEBI CHEBI:17761 ceramide -cetuximab CHEMBL 1201577 . -CFM-4 PUBCHEM 2871439 . -chaperonin containing TCP-1 FPLX 000085 CCT_complex -chaperonin FPLX 000085 CCT_complex -chaperonin-containing t-complex polypeptide 1 FPLX 000085 CCT_complex -chaperonin-containing TCP1 complex FPLX 000085 CCT_complex -checkpoint kinase FPLX 000098 CHEK -chemoattractant receptor FPLX 000100 Chemokine_receptor -chemokine FPLX 000099 Chemokine -chemokines FPLX 000099 Chemokine -CHIP UP Q9UNE7 CHIP_HUMAN -CHK1 UP O14757 CHK1_HUMAN -Chk1 UP O14757 CHK1_HUMAN -CHK2 UP O96017 CHK2_HUMAN -Chk2 UP O96017 CHK2_HUMAN -cholesterol CHEBI CHEBI:16113 cholesterol -cholesterol PUBCHEM 5997 . -choline esterase FPLX 000101 Cholinesterase -cholinesterase FPLX 000101 Cholinesterase -CHOP UP P35638 DDIT3_HUMAN -CIP1 UP P38936 CDN1A_HUMAN -CIP2A UP Q8TCG1 CIP2A_HUMAN -Cisplatin CHEBI CHEBI:27899 cisplatin -Cisplatin PUBCHEM 441203 . -cisplatin CHEBI CHEBI:27899 cisplatin -cisplatin PUBCHEM 441203 . -CK2 FPLX 000104 CK2 -CKI FPLX 000094 CDKN -Clade B serpin FPLX 000431 SERPINB -clade B serpins FPLX 000431 SERPINB -Class 1 NF-kappaBs FPLX 000312 NFkappaB_1 -class 1 NF-kappaBs FPLX 000312 NFkappaB_1 -Class 1 NF-κBs FPLX 000312 NFkappaB_1 -class 1 NF-κBs FPLX 000312 NFkappaB_1 -Class 2 NF-kappaBs FPLX 000313 NFkappaB_2 -class 2 NF-kappaBs FPLX 000313 NFkappaB_2 -Class 2 NF-κBs FPLX 000313 NFkappaB_2 -class 2 NF-κBs FPLX 000313 NFkappaB_2 -Class C GPCR FPLX 000187 GPCR -Class I HDACs FPLX 000221 HDAC_I -class I HDACs FPLX 000221 HDAC_I -class I histone deacetylases FPLX 000221 HDAC_I -Class I NF-kappaBs FPLX 000312 NFkappaB_1 -class I NF-kappaBs FPLX 000312 NFkappaB_1 -Class I NF-κBs FPLX 000312 NFkappaB_1 -class I NF-κBs FPLX 000312 NFkappaB_1 -class II HDACs FPLX 000222 HDAC_II -class II histone deacetylases FPLX 000222 HDAC_II -Class II NF-kappaBs FPLX 000313 NFkappaB_2 -class II NF-kappaBs FPLX 000313 NFkappaB_2 -Class II NF-κBs FPLX 000313 NFkappaB_2 -class II NF-κBs FPLX 000313 NFkappaB_2 -Class III HDACs FPLX 000223 HDAC_III -class III HDACs FPLX 000223 HDAC_III -class III histone deacetylases FPLX 000223 HDAC_III -Class IV HDACs FPLX 000224 HDAC_IV -class IV HDACs FPLX 000224 HDAC_IV -class IV histone deacetylases FPLX 000224 HDAC_IV -clathrin coat FPLX 000105 Clathrin -clathrin FPLX 000105 Clathrin -cleaved PARP UP P09874 PARP1_HUMAN -cMet receptor UP P08581 MET_HUMAN -CNKSR FPLX 000106 CNKSR -CO 2 CHEBI CHEBI:16526 carbon dioxide -CO 2 PUBCHEM 280 . -CO CHEBI CHEBI:17245 carbon monoxide -CO PUBCHEM 281 . -cocaine PUBCHEM 446220 . -cocaine CHEBI CHEBI:27958 cocaine -cofilin FPLX 000107 Cofilin -cohesin complex FPLX 000108 Cohesin -cohesin FPLX 000108 Cohesin -Col4 FPLX 000110 COL4 -COLGALT FPLX 000112 COLGALT -ColIV FPLX 000110 COL4 -Collagen beta(1-O)galactosyltransferase FPLX 000112 COLGALT -Collagen beta(1-O)galactosyltransferases FPLX 000112 COLGALT -collagen beta(1-O)galactosyltransferase FPLX 000112 COLGALT -collagen beta(1-O)galactosyltransferases FPLX 000112 COLGALT -collagen IV FPLX 000110 COL4 -collagen type I FPLX 000109 COL1 -Collagen Type IV FPLX 000110 COL4 -collagen type IV FPLX 000110 COL4 -collagen type V FPLX 000111 COL5 -collagen MESH D003094 Collagen -collagen CHEBI CHEBI:3815 Collagen -complex II FPLX 000502 ETC_complex_II -complex III FPLX 000503 ETC_complex_III -Complex IV FPLX 000113 COX -connector enhancer of kinase suppressor of ras FPLX 000106 CNKSR -copper CHEBI CHEBI:29036 copper(2+) -copper PUBCHEM 27099 . -cortactin IP IPR015503 . -cortactin UP Q14247 SRC8_HUMAN -COX-2 UP P35354 PGH2_HUMAN -Cox4 FPLX 000114 COX4 -COX6A FPLX 000115 COX6A -Cox6a FPLX 000115 COX6A -Cox6b FPLX 000116 COX6B -COX7A FPLX 000117 COX7A -Cox7a FPLX 000117 COX7A -Cox7b FPLX 000118 COX7B -Cox8 FPLX 000119 COX8 -cPARP UP P09874 PARP1_HUMAN -cPLA2 FPLX 000366 PLA2 -CRAF UP P04049 RAF1_HUMAN -CREB family FPLX 000120 CREB -CREB FPLX 000120 CREB -CRISP FPLX 000121 CRISP -CRISPs FPLX 000121 CRISP -Crk UP P46108 CRK_HUMAN -CRSP complex FPLX 000122 CRSP -CRSP FPLX 000122 CRSP -CRSP/Med complex FPLX 000122 CRSP -CsA PUBCHEM 5284373 . -CsA CHEBI CHEBI:4031 cyclosporin A -CSC MESH D014411 Neoplastic Stem Cells -CSF-1R UP P07333 CSF1R_HUMAN -CSNK1 FPLX 000124 CSNK1 -CSNK2 FPLX 000125 CSNK2 -CtIP UP Q99708 CTIP_HUMAN -cTnC FPLX 000478 Troponin_C -cTnI FPLX 000478 Troponin_C -cTnT FPLX 000480 Troponin_T -cullin proteins FPLX 000127 CUL -cullin FPLX 000127 CUL -cullins FPLX 000127 CUL -Curcumin CHEBI CHEBI:3962 curcumin -Curcumin PUBCHEM 969516 . -curcumin CHEBI CHEBI:3962 curcumin -curcumin PUBCHEM 969516 . -CXCL12 UP P48061 SDF1_HUMAN -CXCL8 UP P10145 IL8_HUMAN -CXCR2 UP P25025 CXCR2_HUMAN -CXCR4 UP P61073 CXCR4_HUMAN -cyclic AMP-dependent protein kinase FPLX 000363 PKA -cyclic-AMP-dependent protein kinase FPLX 000363 PKA -Cyclin A FPLX 000131 Cyclin_A -cyclin A FPLX 000131 Cyclin_A -Cyclin D FPLX 000132 Cyclin_D -Cyclin D2 UP P30279 CCND2_HUMAN -cyclin D2 UP P30279 CCND2_HUMAN -cyclin dependent kinase inhibitors FPLX 000094 CDKN -cyclin E FPLX 000133 Cyclin_E -cyclin family FPLX 000130 Cyclin -Cyclin FPLX 000130 Cyclin -cyclin FPLX 000130 Cyclin -Cyclin-A FPLX 000131 Cyclin_A -cyclin-dependent kinase inhibitor FPLX 000094 CDKN -cyclin-dependent protein kinase inhibitors FPLX 000094 CDKN -cyclins FPLX 000130 Cyclin -cyclophilin FPLX 000134 Cyclophilin -cyclophilins FPLX 000134 Cyclophilin -CYLD UP Q9NQC7 CYLD_HUMAN -cypermethrin CHEBI CHEBI:4042 cypermethrin -cypermethrin PUBCHEM 2912 . -cysteine rich secretory proteins FPLX 000121 CRISP -cysteine-rich secretory proteins FPLX 000121 CRISP -cytochrome bc1 complex FPLX 000503 ETC_complex_III -Cytochrome c oxidase subunit 6a FPLX 000115 COX6A -cytochrome c oxidase subunit VIII FPLX 000119 COX8 -cytochrome c oxidase FPLX 000113 COX -cytochrome C UP P99999 CYC_HUMAN -cytochrome c UP P99999 CYC_HUMAN -cytokine production GO GO:0001816 cytokine production -cytoplasmic dynein FPLX 000135 Cytoplasmic_dynein -cytosolic phospholipase A(2) FPLX 000366 PLA2 -cytosolic phospholipase A2 FPLX 000366 PLA2 -cytosolic PLA2 FPLX 000366 PLA2 -DA PUBCHEM 681 . -DA CHEBI CHEBI:18243 dopamine -dabrafenib PUBCHEM 44462760 . -dabrafenib CHEBI CHEBI:75045 dabrafenib -DAG kinase FPLX 000140 DGK -DAG PUBCHEM 6026790 . -DAG CHEBI CHEBI:85682 diacylglycerol 30:1 -damage MESH D004249 DNA Damage -Danusertib PUBCHEM 11442891 . -Danusertib CHEMBL CHEMBL402548 . -Danusertib CHEBI CHEBI:94490 N-[5-[(2R)-2-methoxy-1-oxo-2-phenylethyl]-4,6-dihydro-1H-pyrrolo[3,4-c]pyrazol-3-yl]-4-(4-methyl-1-piperazinyl)benzamide -danusertib PUBCHEM 11442891 . -danusertib CHEMBL CHEMBL402548 . -danusertib CHEBI CHEBI:94490 N-[5-[(2R)-2-methoxy-1-oxo-2-phenylethyl]-4,6-dihydro-1H-pyrrolo[3,4-c]pyrazol-3-yl]-4-(4-methyl-1-piperazinyl)benzamide -dapagliflozin CHEBI CHEBI:85078 dapagliflozin -dapagliflozin PUBCHEM 9887712 . -dasatinib CHEBI CHEBI:49375 dasatinib (anhydrous) -dasatinib PUBCHEM 3062316 . -DDR GO GO:0042769 DNA damage response, detection of DNA damage -death receptor FPLX 000137 Death_receptor -death receptors FPLX 000137 Death_receptor -death GO GO:0008219 cell death -death MESH D016923 Cell Death -delta-tubulin HGNC 16811 TUBD1 -desmoglein FPLX 000138 Desmoglein -desmogleins FPLX 000138 Desmoglein -dexamethasone PUBCHEM 5743 . -dexamethasone CHEBI CHEBI:41879 dexamethasone -DGC FPLX 000139 DGC -DGK FPLX 000140 DGK -DHA CHEBI CHEBI:207229 dihydroartemisinin -DHA PUBCHEM 6918483 . -DHT PUBCHEM 11302 . -DHT CHEBI CHEBI:2150 5beta-dihydrotestosterone -diacyl glycerol kinase FPLX 000140 DGK -diacylglycerol kinase FPLX 000140 DGK -differentiation GO GO:0030154 cell differentiation -differentiation MESH D002454 Cell Differentiation -diosmetin CHEBI CHEBI:4630 diosmetin -diosmetin PUBCHEM 5281612 . -discoidin domain receptor family FPLX 000136 DDR -discoidin domain receptors FPLX 000136 DDR -discoidin domain-containing receptor FPLX 000136 DDR -dishevelled FPLX 000145 DVL -DNA polymerase delta FPLX 000141 DNA_polymerase_delta -DNA polymerase δ FPLX 000141 DNA_polymerase_delta -DNA repair GO GO:0006281 DNA repair -DNA repair MESH D004260 DNA Repair -DNA replication factor C complex FPLX 000411 RFC -DNA replication factor C FPLX 000411 RFC -DNA-PKcs UP P78527 PRKDC_HUMAN -DNA-Pkcs UP P78527 PRKDC_HUMAN -docetaxel PUBCHEM 148124 . -docetaxel CHEBI CHEBI:4672 docetaxel anhydrous -Dok1 UP Q99704 DOK1_HUMAN -Dok2 UP O60496 DOK2_HUMAN -dopamine receptor FPLX 000143 DRD -dopamine receptors FPLX 000143 DRD -dopamine PUBCHEM 681 . -dopamine CHEBI CHEBI:18243 dopamine -doxorubicin CHEBI CHEBI:28748 doxorubicin -doxorubicin PUBCHEM 31703 . -doxycycline PUBCHEM 54671203 . -doxycycline CHEBI CHEBI:50845 doxycycline -DP complex FPLX 000464 TFDP -DR4 UP O00220 TR10A_HUMAN -DR5 UP O14763 TR10B_HUMAN -DSB MESH D053903 DNA Breaks, Double-Stranded -DUSP FPLX 000144 DUSP -DUSP1 UP P28562 DUS1_HUMAN -Dvl FPLX 000145 DVL -dynamin family FPLX 000142 DNM -dynamin FPLX 000142 DNM -dystrophin glycoprotein complex FPLX 000139 DGC -dystrophin glycoprotein FPLX 000139 DGC -dystrophin-associated glycoprotein complex FPLX 000139 DGC -dystrophin-glycoprotein complex FPLX 000139 DGC -E-cadherin UP P12830 CADH1_HUMAN -E2 enzyme FPLX 000489 UBE2 -E2 ubiquitin-conjugating enzyme FPLX 000489 UBE2 -E2 FPLX 000489 UBE2 -E2 UP P27958 POLG_HCVH -E2F FPLX 000147 E2F -E2F-1 UP Q01094 E2F1_HUMAN -E2F1 UP Q01094 E2F1_HUMAN -E3 ubiquitin ligase FPLX 000148 E3_Ub_ligase -E3 FPLX 000148 E3_Ub_ligase -E6 UP P03126 VE6_HPV16 -E7 UP P03129 VE7_HPV16 -early growth response proteins FPLX 000151 EGR -EBNA3C UP I1YP21 None -ECM GO GO:0031012 extracellular matrix -Ect2 UP Q9H8V3 ECT2_HUMAN -EGCG PUBCHEM 65064 . -EGCG CHEBI CHEBI:4806 (-)-epigallocatechin 3-gallate -EGF receptor UP P00533 EGFR_HUMAN -EGF UP P01133 EGF_HUMAN -EGFR ligand FPLX 000150 EGFR_ligand -EGFR ligands FPLX 000150 EGFR_ligand -EGFR UP P00533 EGFR_HUMAN -EGFRvIII UP P00533 EGFR_HUMAN -EGR FPLX 000151 EGR -eIF2alpha UP P05198 IF2A_HUMAN -EIF2B FPLX 000152 EIF2B -eIF2B FPLX 000152 EIF2B -eIF2α UP P05198 IF2A_HUMAN -eIF4A FPLX 000153 EIF4A -eIF4E UP P06730 IF4E_HUMAN -eIF4G FPLX 000155 EIF4G -elastase FPLX 000156 ELA -Elk-1 UP P19419 ELK1_HUMAN -Elk1 UP P19419 ELK1_HUMAN -ELMO1 UP Q92556 ELMO1_HUMAN -ELR (+) CXC chemokines FPLX 000129 CXCL_ELR_positive -ELR (-) CXC chemokines FPLX 000128 CXCL_ELR_negative -ELR-negative CXC chemokine FPLX 000128 CXCL_ELR_negative -ELR-negative CXC family FPLX 000128 CXCL_ELR_negative -ELR-positive CXC chemokine FPLX 000129 CXCL_ELR_positive -ELR-positive CXC family FPLX 000129 CXCL_ELR_positive -embelin CHEBI CHEBI:4778 embelin -embelin PUBCHEM 3218 . -emodin PUBCHEM 3220 . -emodin CHEBI CHEBI:42223 emodin -EMT GO GO:0001837 epithelial to mesenchymal transition -EMT MESH D058750 Epithelial-Mesenchymal Transition -endocytosis GO GO:0006897 endocytosis -endocytosis MESH D004705 Endocytosis -endothelin FPLX 000149 EDN -endothelins FPLX 000149 EDN -enolase FPLX 000157 ENO -eNOS UP P29474 NOS3_HUMAN -Env UP U3LIR9 None -Eph receptor FPLX 000158 Ephrin_receptor -Eph receptors FPLX 000158 Ephrin_receptor -EphA2 UP P29317 EPHA2_HUMAN -EphB1 UP P54762 EPHB1_HUMAN -ephrin receptor FPLX 000158 Ephrin_receptor -epidermal growth factor receptor UP P00533 EGFR_HUMAN -epidermal growth factor UP P01133 EGF_HUMAN -Eps8 UP Q12929 EPS8_HUMAN -epsilon-tubulin HGNC 20775 TUBE1 -epsin FPLX 000159 EPN -epsins FPLX 000159 EPN -ER FPLX 000162 ESR -ER MESH D004721 Endoplasmic Reticulum -ER GO GO:0005783 endoplasmic reticulum -ER UP P03372 ESR1_HUMAN -ERalpha UP P03372 ESR1_HUMAN -ErbB FPLX 000160 ERBB -ERBB2 UP P04626 ERBB2_HUMAN -ErbB2 UP P04626 ERBB2_HUMAN -ErbB3 UP P21860 ERBB3_HUMAN -ERK 1/2 FPLX 000161 ERK -ERK inhibitors CHEBI CHEBI:79091 EC 2.7.11.24 (mitogen-activated protein kinase) inhibitor -ERK MAPK FPLX 000161 ERK -ERK mitogen-activated protein kinase FPLX 000161 ERK -ERK FPLX 000161 ERK -Erk FPLX 000161 ERK -ERK-1/2 FPLX 000161 ERK -ERK1 UP P27361 MK03_HUMAN -Erk1 UP P27361 MK03_HUMAN -ERK1/2 MAPK FPLX 000161 ERK -ERK1/2 FPLX 000161 ERK -Erk1/2 FPLX 000161 ERK -ERK2 UP P28482 MK01_HUMAN -ERK5 UP Q13164 MK07_HUMAN -ERKs FPLX 000161 ERK -erlotinib PUBCHEM 176870 . -erlotinib CHEBI CHEBI:114785 erlotinib -ERα UP P03372 ESR1_HUMAN -ESR FPLX 000162 ESR -estradiol CHEBI CHEBI:23965 estradiol -estradiol PUBCHEM 9811784 . -estrogen receptor UP P03372 ESR1_HUMAN -estrogen CHEBI CHEBI:50114 estrogen -ET-1 UP P05305 EDN1_HUMAN -ethanol PUBCHEM 702 . -ethanol CHEBI CHEBI:16236 ethanol -ethanol HMDB HMDB00108 . -etoposide PUBCHEM 36462 . -etoposide CHEBI CHEBI:4911 etoposide -ETS FPLX 000163 ETS -ETS-1 UP P14921 ETS1_HUMAN -Ets-1 UP P14921 ETS1_HUMAN -ETS1 UP P14921 ETS1_HUMAN -eukaryotic initiation factor 4E UP P06730 IF4E_HUMAN -eukaryotic initiation factor-4A FPLX 000153 EIF4A -Everolimus PUBCHEM 6442177 . -Everolimus CHEBI CHEBI:68478 everolimus -everolimus PUBCHEM 6442177 . -everolimus CHEBI CHEBI:68478 everolimus -EXOC FPLX 000164 EXOC -exocyst complex FPLX 000164 EXOC -exocyst FPLX 000164 EXOC -Exostosin glycosyltransferase family FPLX 000165 EXT -exostosin glycosyltransferase family FPLX 000165 EXT -EXT FPLX 000165 EXT -Extracellular Signal Regulated Kinase FPLX 000161 ERK -extracellular signal-regulated kinase FPLX 000161 ERK -EZH2 UP Q15910 EZH2_HUMAN -ezrin UP P15311 EZRI_HUMAN -F-actin FPLX 000178 F_actin -FADD UP Q13158 FADD_HUMAN -FAK UP Q05397 FAK1_HUMAN -FAM83B UP Q5T0W9 FA83B_HUMAN -FANC proteins FPLX 000166 FANC -FANC FPLX 000166 FANC -FANCJ UP Q9BX63 FANCJ_HUMAN -farnesyltransferase FPLX 000172 FNT -Fas UP P25445 TNR6_HUMAN -FasL UP P48023 TNFL6_HUMAN -FGF FPLX 000167 FGF -FGF-2 UP P09038 FGF2_HUMAN -FGF2 UP P09038 FGF2_HUMAN -FGFR FPLX 000168 FGFR -FGFR1 UP P11362 FGFR1_HUMAN -FGFR2 UP P21802 FGFR2_HUMAN -FGFR3 UP P22607 FGFR3_HUMAN -FGFR4 UP P22455 FGFR4_HUMAN -fibrinogen FPLX 000169 Fibrinogen -fibronectin UP P02751 FINC_HUMAN -fisetin CHEBI CHEBI:42567 fisetin -fisetin PUBCHEM 5281614 . -Flip UP O15519 CFLAR_HUMAN -flotillin FPLX 000170 FLOT -FLRT family FPLX 000171 FLRT -Flrt family FPLX 000171 FLRT -FLRT proteins FPLX 000171 FLRT -FLT3 UP P36888 FLT3_HUMAN -FN UP P02751 FINC_HUMAN -follicle-stimulating hormone FPLX 000175 FSH -FOS FPLX 000173 FOS_family -Fos FPLX 000173 FOS_family -FOXM1 UP Q08050 FOXM1_HUMAN -FOXO FPLX 000174 FOXO -FoxO FPLX 000174 FOXO -FOXO1 UP Q12778 FOXO1_HUMAN -FoxO1 UP Q12778 FOXO1_HUMAN -FOXO3 UP O43524 FOXO3_HUMAN -FOXO3a UP O43524 FOXO3_HUMAN -FoxO3a UP O43524 FOXO3_HUMAN -FRK UP P42685 FRK_HUMAN -fructose-bisphosphate aldolase FPLX 000025 ALDO -FSH FPLX 000175 FSH -FTase FPLX 000172 FNT -FTS PUBCHEM 5469318 . -Fucosyltransferase FPLX 000176 FUT -Fucosyltransferases FPLX 000176 FUT -fucosyltransferase FPLX 000176 FUT -fucosyltransferases FPLX 000176 FUT -FUT FPLX 000176 FUT -Fyn UP P06241 FYN_HUMAN -Fz FPLX 000177 FZD -FZD FPLX 000177 FZD -G 1 GO GO:0051318 G1 phase -G 1 MESH D016193 G1 Phase -G 2 MESH D016195 G2 Phase -G alphai FPLX 000213 G_i_alpha -G alphaq FPLX 000216 G_q_alpha -G alphaS FPLX 000218 G_s_alpha -G protein beta FPLX 000210 G_beta -G protein gamma subunit FPLX 000211 G_gamma -G protein gamma FPLX 000211 G_gamma -G protein Gs FPLX 000217 G_s -G protein γ subunit FPLX 000211 G_gamma -G protein β FPLX 000210 G_beta -G protein γ FPLX 000211 G_gamma -G protein(s) FPLX 000217 G_s -G protein FPLX 000214 G_protein -G protein-coupled receptor kinases FPLX 000192 GRK -G proteins FPLX 000214 G_protein -G S protein FPLX 000217 G_s -G αi FPLX 000213 G_i_alpha -G αq FPLX 000216 G_q_alpha -G αS FPLX 000218 G_s_alpha -G(12) FPLX 000207 G_12 -G(q/11) FPLX 000215 G_q -G-alpha(s) FPLX 000218 G_s_alpha -G-AlphaS FPLX 000218 G_s_alpha -G-protein alpha-12 FPLX 000208 G_12_alpha -G-Protein alpha-i FPLX 000213 G_i_alpha -G-Protein alpha-q FPLX 000216 G_q_alpha -G-Protein alpha-s FPLX 000218 G_s_alpha -G-protein beta FPLX 000210 G_beta -G-protein β FPLX 000210 G_beta -G-protein α-12 FPLX 000208 G_12_alpha -G-Protein α-i FPLX 000213 G_i_alpha -G-Protein α-q FPLX 000216 G_q_alpha -G-Protein α-s FPLX 000218 G_s_alpha -G-α(s) FPLX 000218 G_s_alpha -G-αS FPLX 000218 G_s_alpha -G12 family FPLX 000207 G_12 -G12 proteins FPLX 000207 G_12 -G12 FPLX 000207 G_12 -GA PUBCHEM 370 . -GA CHEBI CHEBI:30778 gallic acid -Ga12 FPLX 000208 G_12_alpha -Gab1 UP Q13480 GAB1_HUMAN -Gab2 UP Q9UQC2 GAB2_HUMAN -GABA receptor FPLX 000179 GABR -GABA receptors FPLX 000179 GABR -GABA-A receptor FPLX 000179 GABR -GALNT FPLX 000180 GALNT -Galpha12 FPLX 000208 G_12_alpha -Galphai FPLX 000213 G_i_alpha -Galphaq FPLX 000216 G_q_alpha -GalphaS FPLX 000218 G_s_alpha -gamma secretase FPLX 000181 Gamma_secretase -Gamma tubulin FPLX 000485 TUBG -gamma tubulin FPLX 000485 TUBG -gamma-aminobutyric-acid A receptor FPLX 000179 GABR -gamma-secretase FPLX 000181 Gamma_secretase -gamma-tubulin FPLX 000485 TUBG -GAP FPLX 000182 GAP -Gas6 receptors FPLX 000183 GAS6_receptor -gastrin UP P01350 GAST_HUMAN -GATA family FPLX 000184 GATA -GATA FPLX 000184 GATA -Gbeta FPLX 000210 G_beta -GCNT FPLX 000185 GCNT -GDF15 UP Q99988 GDF15_HUMAN -GDP HMDB HMDB01201 . -GDP PUBCHEM 135398619 . -GDP CHEBI CHEBI:17552 GDP -GEF FPLX 000186 GEF -GEF-H1 UP Q92974 ARHG2_HUMAN -gefitinib PUBCHEM 123631 . -gefitinib CHEBI CHEBI:49668 gefitinib -GEFs FPLX 000186 GEF -general transcription factor II E FPLX 000196 GTF2E -general transcription factor II F FPLX 000197 GTF2F -genistein CHEBI CHEBI:28088 genistein -genistein PUBCHEM 5280961 . -Gi alpha subunit FPLX 000213 G_i_alpha -Gi alpha FPLX 000213 G_i_alpha -Gi protein FPLX 000212 G_i -Gi α subunit FPLX 000213 G_i_alpha -Gi α FPLX 000213 G_i_alpha -Gi FPLX 000212 G_i -GII PLA2 FPLX 000367 PLA2G2 -GIIPLA2 FPLX 000367 PLA2G2 -gIV-PLA(2) FPLX 000368 PLA2G4 -glucose transporter FPLX 000434 SLC2A -glucose transporters FPLX 000434 SLC2A -Glucose HMDB HMDB00122 . -glucose HMDB HMDB00122 . -GLUT FPLX 000434 SLC2A -glutamate metabotropic receptors FPLX 000193 GRM -glutathione peroxidase FPLX 000190 GPX -glutathione S-transferase FPLX 000195 GST -glutathione PUBCHEM 124886 . -glutathione CHEBI CHEBI:16856 glutathione -glutathione HMDB HMDB00125 . -Glycogen phosphorylase FPLX 000396 PYG -Glycogen phosphorylases FPLX 000396 PYG -glycogen phosphorylase FPLX 000396 PYG -glycogen phosphorylases FPLX 000396 PYG -glycogen synthase FPLX 000206 GYS -glycolysis GO GO:0006096 glycolytic process -glycolysis MESH D006019 Glycolysis -glycoprotein Ib-V-IX complex FPLX 000188 GPIb_IX_V -Glycoprotein Ib-V-IX FPLX 000188 GPIb_IX_V -Glycoprotein Ib/V/IX FPLX 000188 GPIb_IX_V -glycosylphosphatidylinositol transamidase complex FPLX 000189 GPIT -Glycosyltransferase family 2 FPLX 000199 GTF_family_2 -glycosyltransferase family 2 FPLX 000199 GTF_family_2 -Glycosyltransferase family 29 FPLX 000202 GTF_family_29 -glycosyltransferase family 29 FPLX 000202 GTF_family_29 -Glycosyltransferase family 6 FPLX 000200 GTF_family_6 -glycosyltransferase family 6 FPLX 000200 GTF_family_6 -Glycosyltransferase family 8 FPLX 000201 GTF_family_8 -glycosyltransferase family 8 FPLX 000201 GTF_family_8 -Glycosyltransferase family 90 FPLX 000203 GTF_family_90 -glycosyltransferase family 90 FPLX 000203 GTF_family_90 -gp120 UP P04578 ENV_HV1H2 -gp47 phox UP P14598 NCF1_HUMAN -gp91 phox UP P04839 CY24B_HUMAN -GPCR kinases FPLX 000192 GRK -GPCR FPLX 000187 GPCR -GPCRs FPLX 000187 GPCR -GPI transamidase complex FPLX 000189 GPIT -GPIb-IX-V complex FPLX 000188 GPIb_IX_V -GPIb-IX-V FPLX 000188 GPIb_IX_V -GpIb-V-IX FPLX 000188 GPIb_IX_V -GPIT complex FPLX 000189 GPIT -GPIT FPLX 000189 GPIT -Gq alpha subunit FPLX 000216 G_q_alpha -Gq alpha FPLX 000216 G_q_alpha -Gq α subunit FPLX 000216 G_q_alpha -Gq α FPLX 000216 G_q_alpha -Gq/11 FPLX 000215 G_q -GR UP P00390 GSHR_HUMAN -GRB2 UP P62993 GRB2_HUMAN -Grb2 UP P62993 GRB2_HUMAN -GRK FPLX 000192 GRK -GRKs FPLX 000192 GRK -group IV-PLA(2) FPLX 000368 PLA2G4 -GRP78 UP P11021 BIP_HUMAN -Gs alpha subunit FPLX 000218 G_s_alpha -Gs alpha FPLX 000218 G_s_alpha -Gs family FPLX 000217 G_s -Gs protein FPLX 000217 G_s -Gs α subunit FPLX 000218 G_s_alpha -Gs α FPLX 000218 G_s_alpha -GSH PUBCHEM 124886 . -GSH CHEBI CHEBI:16856 glutathione -GSH HMDB HMDB00125 . -GSK-3 FPLX 000194 GSK3 -GSK-3beta UP P49841 GSK3B_HUMAN -GSK-3β UP P49841 GSK3B_HUMAN -GSK3 FPLX 000194 GSK3 -GSK3beta UP P49841 GSK3B_HUMAN -GSK3β UP P49841 GSK3B_HUMAN -GST FPLX 000195 GST -GSTs FPLX 000195 GST -GTP HMDB HMDB01273 . -GTP CHEBI CHEBI:15996 GTP -GTP PUBCHEM 135398633 . -GTPase FPLX 000204 GTPase -GTPase-activating proteins FPLX 000182 GAP -guanine PUBCHEM 135398634 . -guanine CHEBI CHEBI:16235 guanine -guanylate cyclase FPLX 000205 GUCY -guanylyl cyclase FPLX 000205 GUCY -G_alpha FPLX 000209 G_alpha -G_α FPLX 000209 G_alpha -Gβ FPLX 000210 G_beta -Gα12 FPLX 000208 G_12_alpha -Gαi FPLX 000213 G_i_alpha -Gαq FPLX 000216 G_q_alpha -GαS FPLX 000218 G_s_alpha -H-Ras UP P01112 RASH_HUMAN -H/R MESH D015687 Cell Hypoxia -H2AX UP P16104 H2AX_HUMAN -H2B FPLX 000236 Histone_H2B -H3 FPLX 000237 Histone_H3 -h9-1-1 complex FPLX 000001 9_1_1 -haem oxygenase FPLX 000240 HMOX -hAxin FPLX 000062 AXIN -HB-EGF UP Q99075 HBEGF_HUMAN -HBx UP Q157B2 None -hCG FPLX 000219 hCG -HDAC inhibitor CHEBI CHEBI:61115 EC 3.5.1.98 (histone deacetylase) inhibitor -HDAC FPLX 000220 HDAC -HDAC1 UP Q13547 HDAC1_HUMAN -HDAC2 UP Q92769 HDAC2_HUMAN -HDAC3 UP O15379 HDAC3_HUMAN -HDACi CHEBI CHEBI:61115 EC 3.5.1.98 (histone deacetylase) inhibitor -HDL FPLX 000225 HDL -HDM2 UP Q00987 MDM2_HUMAN -Heat Shock Protein 70 FPLX 000244 HSPA -heat shock protein family B FPLX 000245 HSPB -Hedgehog family FPLX 000226 Hedgehog -hedgehog protein FPLX 000226 Hedgehog -hedgehog signaling proteins FPLX 000226 Hedgehog -Hedgehog FPLX 000226 Hedgehog -heme oxygenase FPLX 000240 HMOX -hemoglobin FPLX 000227 Hemoglobin -HER-2 UP P04626 ERBB2_HUMAN -HER2 receptor UP P04626 ERBB2_HUMAN -HER2 UP P04626 ERBB2_HUMAN -HER3 UP P21860 ERBB3_HUMAN -Hes gene family FPLX 000228 HES -Hes genes FPLX 000228 HES -HES FPLX 000228 HES -Hes FPLX 000228 HES -HG HMDB HMDB00122 . -HGF UP P14210 HGF_HUMAN -Hic-5 UP O43294 TGFI1_HUMAN -HIF FPLX 000229 HIF -HIF-1 FPLX 000230 HIF1 -HIF-1alpha protein UP Q16665 HIF1A_HUMAN -HIF-1alpha UP Q16665 HIF1A_HUMAN -HIF-1α protein UP Q16665 HIF1A_HUMAN -HIF-1α UP Q16665 HIF1A_HUMAN -HIF1alpha protein UP Q16665 HIF1A_HUMAN -HIF1alpha UP Q16665 HIF1A_HUMAN -HIF1α protein UP Q16665 HIF1A_HUMAN -HIF1α UP Q16665 HIF1A_HUMAN -HIFalpha FPLX 000231 HIF_alpha -Hifalpha FPLX 000231 HIF_alpha -HIFbeta FPLX 000232 HIF_beta -Hifbeta FPLX 000232 HIF_beta -HIFs FPLX 000229 HIF -HIFα FPLX 000231 HIF_alpha -Hifα FPLX 000231 HIF_alpha -HIFβ FPLX 000232 HIF_beta -Hifβ FPLX 000232 HIF_beta -High-density lipoproteins FPLX 000225 HDL -HIPK2 UP Q9H2X6 HIPK2_HUMAN -Histone 2A FPLX 000235 Histone_H2A -histone deacetylase FPLX 000220 HDAC -histone deacetylases FPLX 000220 HDAC -histone H1 FPLX 000234 Histone_H1 -Histone H2A FPLX 000235 Histone_H2A -histone H2A FPLX 000235 Histone_H2A -histone H2B FPLX 000236 Histone_H2B -histone H3 FPLX 000237 Histone_H3 -histone H4 FPLX 000238 Histone_H4 -Histone FPLX 000233 Histone -histone FPLX 000233 Histone -histone-3 FPLX 000237 Histone_H3 -histones FPLX 000233 Histone -HLA-DR FPLX 000239 HLA_DR -HMGB1 UP P09429 HMGB1_HUMAN -HO-1 UP P09601 HMOX1_HUMAN -homeodomain iroquois proteins FPLX 000265 IRX -HOTAIR HGNC 33510 HOTAIR -HOTAIR NONCODE NONHSAT028507.2 . -HOTAIR LNCRNADB HOTAIR . -HR GO GO:0000725 recombinational repair -HR MESH D059767 Recombinational DNA Repair -HRAS UP P01112 RASH_HUMAN -HRASV12 UP P01112 RASH_HUMAN -HSF1 UP Q00613 HSF1_HUMAN -HSP20 UP O14558 HSPB6_HUMAN -HSP27 UP P04792 HSPB1_HUMAN -HSP70 FPLX 000244 HSPA -Hsp70 FPLX 000244 HSPA -HSP90 FPLX 000241 HSP90 -Hsp90 FPLX 000241 HSP90 -HSP90A FPLX 000242 HSP90A -HSP90AA FPLX 000243 HSP90AA -HSPB proteins FPLX 000245 HSPB -HSPB FPLX 000245 HSPB -hTERT UP O14746 TERT_HUMAN -HuR HGNC 3312 ELAVL1 -HuR UP Q15717 ELAV1_HUMAN -hydrogen peroxide PUBCHEM 784 . -hydrogen peroxide CHEBI CHEBI:16240 hydrogen peroxide -hypoxia-inducible factors FPLX 000229 HIF -I/R MESH D011839 Radiation, Ionizing -ICAM-1 UP P05362 ICAM1_HUMAN -IER3 UP P46695 IEX1_HUMAN -IFI16 UP Q16666 IF16_HUMAN -IFN FPLX 000262 Interferon -IFN-a FPLX 000246 IFNA -IFN-alpha FPLX 000246 IFNA -IFN-beta FPLX 000247 IFNB -IFN-beta UP P01574 IFNB_HUMAN -IFN-gamma UP P01579 IFNG_HUMAN -IFN-α FPLX 000246 IFNA -IFN-β FPLX 000247 IFNB -IFN-β UP P01574 IFNB_HUMAN -IFN-γ UP P01579 IFNG_HUMAN -IFNalpha FPLX 000246 IFNA -IFNgamma UP P01579 IFNG_HUMAN -IFNGR FPLX 000263 Interferon_gamma_receptor -IFNα FPLX 000246 IFNA -IFNγ UP P01579 IFNG_HUMAN -IGF-1 UP P05019 IGF1_HUMAN -IGF-1R UP P08069 IGF1R_HUMAN -IGF-1Rbeta UP P08069 IGF1R_HUMAN -IGF-1Rβ UP P08069 IGF1R_HUMAN -IGF-BP FPLX 000248 IGFBP -IGF-I UP P05019 IGF1_HUMAN -IGF-IR UP P08069 IGF1R_HUMAN -IGF1 UP P05019 IGF1_HUMAN -IGF1R UP P08069 IGF1R_HUMAN -IGFBP FPLX 000248 IGFBP -IGFBPs FPLX 000248 IGFBP -IkappaB kinase FPLX 000251 IKK_family -IkappaB FPLX 000249 IKB -IkappaB-alpha HGNC 7797 NFKBIA -IkappaBalpha UP P25963 IKBA_HUMAN -IKK complex FPLX 000250 IKK_complex -IKK FPLX 000251 IKK_family -IKKalpha UP O15111 IKKA_HUMAN -IKKbeta UP O14920 IKKB_HUMAN -IKKβ UP O14920 IKKB_HUMAN -IKKα UP O15111 IKKA_HUMAN -IL-1 FPLX 000252 IL1 -IL-10 UP P22301 IL10_HUMAN -IL-12 FPLX 000253 IL12 -IL-15 receptor FPLX 000254 IL15R -IL-15R FPLX 000254 IL15R -IL-17 UP Q16552 IL17_HUMAN -IL-18 UP Q14116 IL18_HUMAN -IL-1beta UP P01584 IL1B_HUMAN -IL-1β UP P01584 IL1B_HUMAN -IL-2 receptor FPLX 000255 IL2R -IL-2 UP P60568 IL2_HUMAN -IL-2R FPLX 000255 IL2R -IL-4 UP P05112 IL4_HUMAN -IL-6 UP P05231 IL6_HUMAN -IL-8 UP P10145 IL8_HUMAN -IL1 family FPLX 000252 IL1 -IL12 FPLX 000253 IL12 -imatinib PUBCHEM 5291 . -imatinib LINCS 10023-103 . -imatinib CHEBI CHEBI:45783 imatinib -immune response GO GO:0006955 immune response -infiltration MESH D009361 Neoplasm Invasiveness -inflammation GO GO:0006954 inflammatory response -inflammation MESH D007249 Inflammation -inflammatory response GO GO:0006954 inflammatory response -inflammatory response MESH 0007249 None -inhibin A FPLX 000257 Inhibin_A -inhibin B FPLX 000258 Inhibin_B -Inhibin FPLX 000256 Inhibin -inhibin FPLX 000256 Inhibin -inhibin-A FPLX 000257 Inhibin_A -inhibin-a FPLX 000257 Inhibin_A -inhibin-B FPLX 000258 Inhibin_B -inhibin-b FPLX 000258 Inhibin_B -initiation factor 4E binding proteins FPLX 000154 EIF4EBP -iNOS UP P35228 NOS2_HUMAN -insulin family FPLX 000259 INS -Insulin receptor family FPLX 000260 INSR -insulin receptor family FPLX 000260 INSR -insulin receptor substrate FPLX 000264 IRS -insulin receptor UP P06213 INSR_HUMAN -insulin receptor/insulin-like growth factor receptor family FPLX 000260 INSR -Insulin UP P01308 INS_HUMAN -insulin UP P01308 INS_HUMAN -insulin-like growth factor binding proteins FPLX 000248 IGFBP -integrin FPLX 000261 Integrins -integrins FPLX 000261 Integrins -Interferon beta FPLX 000247 IFNB -interferon beta FPLX 000247 IFNB -interferon gamma receptor FPLX 000263 Interferon_gamma_receptor -interferon γ receptor FPLX 000263 Interferon_gamma_receptor -Interferon β FPLX 000247 IFNB -interferon β FPLX 000247 IFNB -interferon FPLX 000262 Interferon -interferon-gamma receptor FPLX 000263 Interferon_gamma_receptor -interferon-γ receptor FPLX 000263 Interferon_gamma_receptor -invasion MESH D009361 Neoplasm Invasiveness -invasiveness MESH D009361 Neoplasm Invasiveness -IQGAP1 UP P46940 IQGA1_HUMAN -IR MESH D011839 Radiation, Ionizing -IR UP P06213 INSR_HUMAN -IRF3 UP Q14653 IRF3_HUMAN -iron PUBCHEM 23925 . -iron CHEBI CHEBI:18248 iron atom -Iroquois family FPLX 000265 IRX -Iroquois proteins FPLX 000265 IRX -Iroquois-class homeodomain proteins FPLX 000265 IRX -IRS family FPLX 000264 IRS -IRS FPLX 000264 IRS -IRS-1 UP P35568 IRS1_HUMAN -IRS-2 UP Q9Y4H2 IRS2_HUMAN -IRS1 UP P35568 IRS1_HUMAN -IRS2 UP Q9Y4H2 IRS2_HUMAN -isoflurane PUBCHEM 3763 . -isoflurane CHEBI CHEBI:6015 isoflurane -IκB kinase FPLX 000251 IKK_family -IκB FPLX 000249 IKB -IκB-α HGNC 7797 NFKBIA -IκBα UP P25963 IKBA_HUMAN -JAK FPLX 000266 JAK -Jak FPLX 000266 JAK -JAK2 UP O60674 JAK2_HUMAN -JAKs FPLX 000266 JAK -JNK MAPK FPLX 000267 JNK -JNK FPLX 000267 JNK -JNK1 UP P45983 MK08_HUMAN -JNK1/2 FPLX 000267 JNK -JNKs FPLX 000267 JNK -JQ1 PUBCHEM 46907787 . -JQ1 CHEBI CHEBI:95080 LSM-6332 -JUN FPLX 000268 JUN_family -K-Ras UP P01116 RASK_HUMAN -Kainate receptors FPLX 000269 Kainate_family -kallikrein FPLX 000271 KLK -kallikrein-related peptidases FPLX 000271 KLK -KARs FPLX 000269 Kainate_family -Keap1 UP Q14145 KEAP1_HUMAN -kinetochore centromere binding factor 3 FPLX 000084 CBF3 -kinetochore complex FPLX 000270 Kinetochore -kinetochore FPLX 000270 Kinetochore -kinetochores FPLX 000270 Kinetochore -KLF5 UP Q13887 KLF5_HUMAN -Klf5 UP Q13887 KLF5_HUMAN -KLKs FPLX 000271 KLK -KRAS UP P01116 RASK_HUMAN -Kras UP P01116 RASK_HUMAN -KSR FPLX 000272 KSR -LA CHEBI CHEBI:30314 (R)-lipoic acid -LA PUBCHEM 6112 . -lactate PUBCHEM 91435 . -lactate CHEBI CHEBI:24996 lactate -laminin 332 chains FPLX 000274 Laminin_332 -laminin 332 FPLX 000274 Laminin_332 -laminin-332 chains FPLX 000274 Laminin_332 -laminin-332 FPLX 000274 Laminin_332 -Laminin-5 FPLX 000274 Laminin_332 -laminin-5 FPLX 000274 Laminin_332 -lapatinib PUBCHEM 208908 . -lapatinib CHEBI CHEBI:49603 lapatinib -LAT UP O43561 LAT_HUMAN -LC3 FPLX 000280 MAP1LC3 -Lck UP P06239 LCK_HUMAN -LDH FPLX 000275 LDH -lead PUBCHEM 5352425 . -lead CHEBI CHEBI:25016 lead atom -leptin UP P41159 LEP_HUMAN -LFA-1 (integrin) FPLX 000261 Integrins -LH FPLX 000276 LH -LIF UP P15018 LIF_HUMAN -lipopolysaccharide CHEBI CHEBI:16412 lipopolysaccharide -lipopolysaccharide MESH D008070 Lipopolysaccharides -LKB1 UP Q15831 STK11_HUMAN -LM-1 FPLX 000273 Laminin_111 -LMP1 UP P03230 LMP1_EBVB9 -localization GO GO:0051179 localization -long-chain acyl-CoA synthetase FPLX 000008 ACSL -LPA UP P08519 APOA_HUMAN -LPS CHEBI CHEBI:16412 lipopolysaccharide -LPS MESH D008070 Lipopolysaccharides -LRRK2 UP Q5S007 LRRK2_HUMAN -Luteinizing hormone FPLX 000276 LH -luteinizing hormone FPLX 000276 LH -luteinizing-hormone FPLX 000276 LH -luteolin PUBCHEM 5280445 . -luteolin CHEBI CHEBI:15864 luteolin -MA PUBCHEM 10836 . -MA CHEBI CHEBI:6809 methamphetamine -MA PUBCHEM 73659 . -MA CHEBI CHEBI:66682 maslinic acid -MA UP P04591 GAG_HV1H2 -MAC FPLX 000278 MAC -MAC-1 (integrin) FPLX 000261 Integrins -Mad2 UP Q13257 MD2L1_HUMAN -Maf subfamily FPLX 000279 MAF -MAF FPLX 000279 MAF -Maf FPLX 000279 MAF -maf FPLX 000279 MAF -MAF UP O75444 MAF_HUMAN -Maf UP O75444 MAF_HUMAN -maf UP O75444 MAF_HUMAN -mammalian target of rapamycin UP P42345 MTOR_HUMAN -mangiferin CHEBI CHEBI:6682 mangiferin -mangiferin PUBCHEM 5281647 . -MAP kinase FPLX 000283 MAPK -MAP kinases FPLX 000283 MAPK -MAP2K1 UP Q02750 MP2K1_HUMAN -MAP2K2 UP P36507 MP2K2_HUMAN -MAP3K FPLX 000282 MAP3K -MAP3K2 UP Q9Y2U5 M3K2_HUMAN -MAPK kinase kinase FPLX 000282 MAP3K -MAPK kinase FPLX 000281 MAP2K -MAPK p38 FPLX 000326 p38 -MAPK FPLX 000161 ERK -MAPK1 UP P28482 MK01_HUMAN -MAPK3 UP P27361 MK03_HUMAN -MAPKK kinases FPLX 000282 MAP3K -MAPKKK FPLX 000282 MAP3K -MAPKs FPLX 000283 MAPK -MAZ UP P56270 MAZ_HUMAN -Mcl-1 UP Q07820 MCL1_HUMAN -MCM FPLX 000284 MCM -MCP-1 UP P0CW71 None -MDM2 UP Q00987 MDM2_HUMAN -Mdm2 UP Q00987 MDM2_HUMAN -MDMX UP O15151 MDM4_HUMAN -Mdmx UP O15151 MDM4_HUMAN -MED14 UP O60244 MED14_HUMAN -MED23 UP Q9ULK4 MED23_HUMAN -MEF2 family FPLX 000285 MEF2 -MEF2 FPLX 000285 MEF2 -MEF2C UP Q06413 MEF2C_HUMAN -MEK 1/2 FPLX 000286 MEK -MEK inhibitor CHEBI CHEBI:88286 EC 2.7.12.2 (mitogen-activated protein kinase kinase) inhibitor -MEK inhibitors CHEBI CHEBI:88286 EC 2.7.12.2 (mitogen-activated protein kinase kinase) inhibitor -MEK FPLX 000286 MEK -MEK1 UP Q02750 MP2K1_HUMAN -MEK1/2 FPLX 000286 MEK -melanin PUBCHEM 6325610 . -melanin CHEBI CHEBI:89634 Melanin -melatonin CHEBI CHEBI:16796 melatonin -melatonin PUBCHEM 896 . -membrane attack complex FPLX 000278 MAC -membrane attack FPLX 000278 MAC -MET UP P08581 MET_HUMAN -Met UP P08581 MET_HUMAN -metabolism GO GO:0008152 metabolic process -metabolism MESH D008660 Metabolism -metabotrophic glutamate receptor FPLX 000193 GRM -metabotropic glutamate receptor FPLX 000193 GRM -metastasis MESH D009362 Neoplasm Metastasis -Metformin PUBCHEM 4091 . -Metformin CHEBI CHEBI:6801 metformin -metformin PUBCHEM 4091 . -metformin CHEBI CHEBI:6801 metformin -Metallothionein FPLX 000292 Metallothionein -metallothionein FPLX 000292 Metallothionein -MG132 PUBCHEM 462382 . -MG132 CHEBI CHEBI:75142 N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal -mGluRs FPLX 000193 GRM -MIF UP P14174 MIF_HUMAN -mini-chromosome maintenance complex FPLX 000284 MCM -minichromosome maintenance complex FPLX 000284 MCM -minichromosome maintenance protein complex FPLX 000284 MCM -miR-101 MESH C534072 MIRN101 microRNA, human -miR-101 MIRBASE MI0000103 hsa-mir-101-1 -miR-101 HGNC 31488 MIR101-1 -miR-145 MIRBASE MI0000461 hsa-mir-145 -miR-145 HGNC 31532 MIR145 -miR-155 MIRBASE MI0000681 hsa-mir-155 -miR-155 HGNC 31542 MIR155 -miR-21 MIRBASE MI0000077 hsa-mir-21 -miR-21 HGNC 31586 MIR21 -miR-7 MIRBASE MI0000263 hsa-mir-7-1 -miR-7 HGNC 31638 MIR7-1 -MITF UP O75030 MITF_HUMAN -mammalian mitochondrial ribosome FPLX 000288 Mitochondrial_Ribosome -Mitochondrial ribosome FPLX 000288 Mitochondrial_Ribosome -Mitochondrial Ribosome FPLX 000288 Mitochondrial_Ribosome -mitochondrial ribosomes FPLX 000288 Mitochondrial_Ribosome -Mitochondrial ribosomes FPLX 000288 Mitochondrial_Ribosome -Mitochondrial Ribosomes FPLX 000288 Mitochondrial_Ribosome -mitoribosome FPLX 000288 Mitochondrial_Ribosome -Mitoribosome FPLX 000288 Mitochondrial_Ribosome -55S mammalian mitochondrial ribosome FPLX 000288 Mitochondrial_Ribosome -55S mitoribosome FPLX 000288 Mitochondrial_Ribosome -55s mitoribosome FPLX 000288 Mitochondrial_Ribosome -55S Mitoribosome FPLX 000288 Mitochondrial_Ribosome -55s Mitoribosome FPLX 000288 Mitochondrial_Ribosome -small mitoribosomal subunit FPLX 000289 MRPS -Small Mitoribosomal Subunit FPLX 000289 MRPS -small subunit of the mammalian mitochondrial ribosome FPLX 000289 MRPS -mitochondrial ribosomal small subunit FPLX 000289 MRPS -large mitoribosomal subunit FPLX 000290 MRPL -Large Mitoribosomal Subunit FPLX 000290 MRPL -large subunit of the mammalian mitochondrial ribosome FPLX 000290 MRPL -MGAT FPLX 000287 MGAT -mitochondrial ribosomal large subunit FPLX 000290 MRPL -mitochondrial membrane potential MESH D053078 Membrane Potential, Mitochondrial -mitogen activated protein kinase FPLX 000283 MAPK -mitogen activated protein kinases FPLX 000283 MAPK -mitogen-activated protein kinase kinase FPLX 000281 MAP2K -mitogen-activated protein kinase FPLX 000283 MAPK -mitogen-activated protein kinases FPLX 000283 MAPK -Miz1 UP Q13105 ZBT17_HUMAN -MKK4 UP P45985 MP2K4_HUMAN -MKP-1 UP P28562 DUS1_HUMAN -MKP3 UP Q16828 DUS6_HUMAN -MLC FPLX 000296 MYL -MM MESH D009101 Multiple Myeloma -MMC PUBCHEM 5746 . -MMC CHEBI CHEBI:27504 mitomycin C -MMP FPLX 000291 MMP -MMP-2 UP P08253 MMP2_HUMAN -MMP-9 UP P14780 MMP9_HUMAN -MMP9 UP P14780 MMP9_HUMAN -MMPs FPLX 000291 MMP -Mn CHEBI CHEBI:29035 manganese(2+) -Mn PUBCHEM 27854 . -MST1 UP Q13043 STK4_HUMAN -MST2 UP Q13188 STK3_HUMAN -MT FPLX 000292 Metallothionein -mTOR inhibitor CHEBI CHEBI:68481 mTOR inhibitor -mTOR inhibitors CHEBI CHEBI:68481 mTOR inhibitor -mTOR UP P42345 MTOR_HUMAN -mTORC1 FPLX 000293 mTORC1 -mTORC2 FPLX 000294 mTORC2 -MTX UP Q13505 MTX1_HUMAN -Mu-A PUBCHEM 375150 . -MUC1 UP P15941 MUC1_HUMAN -mutp53 UP P04637 P53_HUMAN -MYC UP P01106 MYC_HUMAN -Myc UP P01106 MYC_HUMAN -MYCN UP P04198 MYCN_HUMAN -myosin alkali light chain proteins FPLX 000297 MYL_alkali -myosin alkali light chain FPLX 000297 MYL_alkali -myosin heavy chain genes FPLX 000295 MYH -myosin heavy chain isoforms FPLX 000295 MYH -myosin heavy chain protein FPLX 000295 MYH -Myosin heavy chain FPLX 000295 MYH -myosin heavy chain FPLX 000295 MYH -Myosin heavy chains FPLX 000295 MYH -myosin heavy chains FPLX 000295 MYH -myosin light chain protein FPLX 000296 MYL -myosin light chain FPLX 000296 MYL -myosin light chains FPLX 000296 MYL -MYPT1 UP O14974 MYPT1_HUMAN -MYST family FPLX 000300 MYST -MYST histone acetylase FPLX 000300 MYST -MYST proteins FPLX 000300 MYST -N-cadherin UP P19022 CADH2_HUMAN -N-myc downstream regulated gene family FPLX 000307 NDRG -N-Myc UP P04198 MYCN_HUMAN -N-Ras UP P01111 RASN_HUMAN -Na+/K+-exchanging ATPase FPLX 000303 Na_K_ATPase -Na+/K+ATPase FPLX 000303 Na_K_ATPase -Na/K ATPase alpha FPLX 000057 ATP1A -Na/K ATPase α FPLX 000057 ATP1A -Na/K-ATPase FPLX 000303 Na_K_ATPase -NAC PUBCHEM 443227 . -NAC CHEBI CHEBI:7421 NAC -nAChR FPLX 000103 CHRN -NAD(P)H oxidase FPLX 000302 NADPH_oxidase -NAD(P)H-oxidase FPLX 000302 NADPH_oxidase -NADH dehydrogenase (ubiquinone) FPLX 000301 NADH_dehydrogenase -NADH dehydrogenase FPLX 000301 NADH_dehydrogenase -NADPH oxidase FPLX 000302 NADPH_oxidase -NADPH PUBCHEM 5884 . -NADPH CHEBI CHEBI:16474 NADPH -NADPH HMDB HMDB00221 . -naked cuticle FPLX 000315 NKD -NAP UP P80723 BASP1_HUMAN -Natriuretic Peptide FPLX 000304 Natriuretic_peptide -Natriuretic peptide FPLX 000304 Natriuretic_peptide -natriuretic peptide FPLX 000304 Natriuretic_peptide -Natriuretic Peptides FPLX 000304 Natriuretic_peptide -Natriuretic peptides FPLX 000304 Natriuretic_peptide -natriuretic peptides FPLX 000304 Natriuretic_peptide -NDR family FPLX 000307 NDRG -NDR-family FPLX 000307 NDRG -NDRG2 UP Q9UN36 NDRG2_HUMAN -necroptosis GO GO:0070266 necroptotic process -necrosis GO GO:0070265 necrotic cell death -necrosis MESH D009336 Necrosis -Nef UP P03406 NEF_HV1BR -NEMO UP Q9Y6K9 NEMO_HUMAN -neovascularization GO GO:0001525 angiogenesis -neovascularization MESH D018919 Neovascularization, Physiologic -Net1 UP Q7Z628 ARHG8_HUMAN -neuregulin family FPLX 000318 NRG -Neuregulin FPLX 000318 NRG -neuregulin FPLX 000318 NRG -Neuregulins FPLX 000318 NRG -neuregulins FPLX 000318 NRG -Neurexins FPLX 000308 Neurexins -NF-E2 FPLX 000310 NFE -NF-E2-related factor FPLX 000310 NFE -NF-kappaB Class 1 FPLX 000312 NFkappaB_1 -NF-kappaB class 1 FPLX 000312 NFkappaB_1 -NF-kappaB Class 2 FPLX 000313 NFkappaB_2 -NF-kappaB class 2 FPLX 000313 NFkappaB_2 -NF-kappaB Class I FPLX 000312 NFkappaB_1 -NF-kappaB class I FPLX 000312 NFkappaB_1 -NF-kappaB Class II FPLX 000313 NFkappaB_2 -NF-kappaB class II FPLX 000313 NFkappaB_2 -NF-kappaB complexes FPLX 000311 NFkappaB -NF-kappaB dimers FPLX 000311 NFkappaB -NF-kappaB Factors FPLX 000311 NFkappaB -NF-kappaB factors FPLX 000311 NFkappaB -NF-kappaB genes FPLX 000311 NFkappaB -NF-kappaB p50 HGNC 7794 NFKB1 -NF-kappaB p65 HGNC 9955 RELA -NF-kappaB p65 UP Q04206 TF65_HUMAN -NF-kappaB subunits FPLX 000311 NFkappaB -NF-kappaB TFs FPLX 000311 NFkappaB -NF-kappaB FPLX 000311 NFkappaB -NF-kappaB1 HGNC 7794 NFKB1 -NF-kappaB2 HGNC 7795 NFKB2 -NF-kappabeta FPLX 000311 NFkappaB -NF-kappaBp50 HGNC 7794 NFKB1 -NF-kappaBp65 HGNC 9955 RELA -NF-kappaBs FPLX 000311 NFkappaB -NF-kB FPLX 000311 NFkappaB -NF-Y FPLX 000314 NFY -NF-κB Class 1 FPLX 000312 NFkappaB_1 -NF-κB class 1 FPLX 000312 NFkappaB_1 -NF-κB Class 2 FPLX 000313 NFkappaB_2 -NF-κB class 2 FPLX 000313 NFkappaB_2 -NF-κB Class I FPLX 000312 NFkappaB_1 -NF-κB class I FPLX 000312 NFkappaB_1 -NF-κB Class II FPLX 000313 NFkappaB_2 -NF-κB class II FPLX 000313 NFkappaB_2 -NF-κB complexes FPLX 000311 NFkappaB -NF-κB dimers FPLX 000311 NFkappaB -NF-κB Factors FPLX 000311 NFkappaB -NF-κB factors FPLX 000311 NFkappaB -NF-κB genes FPLX 000311 NFkappaB -NF-κB p50 HGNC 7794 NFKB1 -NF-κB p65 HGNC 9955 RELA -NF-κB p65 UP Q04206 TF65_HUMAN -NF-κB subunits FPLX 000311 NFkappaB -NF-κB TFs FPLX 000311 NFkappaB -NF-κB FPLX 000311 NFkappaB -NF-κB1 HGNC 7794 NFKB1 -NF-κB2 HGNC 7795 NFKB2 -NF-κBp50 HGNC 7794 NFKB1 -NF-κBp65 HGNC 9955 RELA -NF-κBs FPLX 000311 NFkappaB -NF-κβ FPLX 000311 NFkappaB -NFAT FPLX 000309 NFAT -NFkappaB complexes FPLX 000311 NFkappaB -NFkappaB p50 HGNC 7794 NFKB1 -NFkappaB p65 HGNC 9955 RELA -NFkappaB FPLX 000311 NFkappaB -NFkappaBp65 HGNC 9955 RELA -NFY FPLX 000314 NFY -NFκB complexes FPLX 000311 NFkappaB -NFκB p50 HGNC 7794 NFKB1 -NFκB p65 HGNC 9955 RELA -NFκB FPLX 000311 NFkappaB -NFκBp65 HGNC 9955 RELA -NGF UP P01138 NGF_HUMAN -nicotine class acetylcholine receptors FPLX 000103 CHRN -nicotinic acetylcholine receptor FPLX 000103 CHRN -nitric oxide PUBCHEM 145068 . -nitric oxide CHEBI CHEBI:16480 nitric oxide -nmMLCK UP Q15746-1 MYLK_HUMAN -nmMLCK1 UP Q15746-1 MYLK_HUMAN -NO HMDB HMDB03378 . -NO CHEBI CHEBI:16480 nitric oxide -NO PUBCHEM 145068 . -non-ELR-CXC chemokines FPLX 000128 CXCL_ELR_negative -NOS FPLX 000316 NOS -Notch FPLX 000317 Notch -Notch1 UP P46531 NOTC1_HUMAN -NOX1 UP Q9Y5S8 NOX1_HUMAN -NOX2 UP P04839 CY24B_HUMAN -NOX3 UP Q9HBY0 NOX3_HUMAN -NOX4 UP Q9NPH5 NOX4_HUMAN -Noxa UP Q13794 APR_HUMAN -NPM UP P06748 NPM_HUMAN -NRAS UP P01111 RASN_HUMAN -NRF2 UP Q16236 NF2L2_HUMAN -Nrf2 UP Q16236 NF2L2_HUMAN -NRG1 UP Q02297 NRG1_HUMAN -NRG1-NRG2 FPLX 000319 NRG_1_2 -NRG1/2 FPLX 000319 NRG_1_2 -NRG3-NRG4 FPLX 000320 NRG_3_4 -NRG3/4 FPLX 000320 NRG_3_4 -NRGs FPLX 000318 NRG -NRXN FPLX 000308 Neurexins -NTF3 UP P20783 NTF3_HUMAN -NTRK FPLX 000321 NTRK -NTRKs FPLX 000321 NTRK -Nuclear factor erythroid 2-related factor FPLX 000310 NFE -nuclear factor Y FPLX 000314 NFY -nuclear factor-Y FPLX 000314 NFY -Nuclear Receptor Co-Repressor FPLX 000306 NCOR -nuclear receptor co-repressor FPLX 000306 NCOR -Nuclear receptor corepressor FPLX 000306 NCOR -nuclear receptor corepressor FPLX 000306 NCOR -Nutlin-3 PUBCHEM 16755649 . -Nutlin-3 CHEBI CHEBI:46742 Nutlin-3 -NVP-BEZ235 PUBCHEM 11977753 . -NVP-BEZ235 LINCS 10232-101 . -NVP-BEZ235 CHEBI CHEBI:71952 dactolisib -NVP-LDE-225 PUBCHEM 24775005 . -NVP-LDE-225 CHEBI CHEBI:90863 sonidegib -OA CHEBI CHEBI:37659 oleanolic acid -OA PUBCHEM 10494 . -OA CHEBI CHEBI:44658 okadaic acid -OA PUBCHEM 446512 . -ofalpha(2)-adrenoceptor FPLX 000020 ADRA2 -ofα(2)-adrenoceptor FPLX 000020 ADRA2 -OPG UP O00300 TR11B_HUMAN -OPN UP P10451 OSTP_HUMAN -ov-serpins FPLX 000431 SERPINB -oxaliplatin CHEBI CHEBI:31941 oxaliplatin -oxaliplatin PUBCHEM 6857599 . -oxygen HMDB HMDB01377 . -oxygen CHEBI CHEBI:15379 dioxygen -oxygen PUBCHEM 977 . -P-REX1 UP Q8TCU6 PREX1_HUMAN -p100 HGNC 7795 NFKB2 -p105 HGNC 7794 NFKB1 -p110 FPLX 000359 PI3K_p110 -p110alpha UP P42336 PK3CA_HUMAN -p110beta UP P42338 PK3CB_HUMAN -p110α UP P42336 PK3CA_HUMAN -p110β UP P42338 PK3CB_HUMAN -p120 UP O60716 CTND1_HUMAN -p130 UP P56945 BCAR1_HUMAN -p16 UP P42771 CDN2A_HUMAN -p160/SRC FPLX 000305 NCOA -p21 Cip1 UP P38936 CDN1A_HUMAN -p21 WAF1 UP P38936 CDN1A_HUMAN -p21 UP P38936 CDN1A_HUMAN -p22 phox UP P13498 CY24A_HUMAN -p27 Kip1 UP P46527 CDN1B_HUMAN -p27 UP P46527 CDN1B_HUMAN -P2X purinoreceptor FPLX 000324 P2RX -P2X purinoreceptors FPLX 000324 P2RX -P2X receptor FPLX 000324 P2RX -P2X receptors FPLX 000324 P2RX -P2X FPLX 000324 P2RX -P2Y receptor FPLX 000325 P2RY -p300 UP Q09472 EP300_HUMAN -P38 MAPK FPLX 000326 p38 -p38 MAPK FPLX 000326 p38 -p38 MAPKs FPLX 000326 p38 -p38 FPLX 000326 p38 -p38-MAPK FPLX 000326 p38 -p38MAPK FPLX 000326 p38 -p40 phox UP Q15080 NCF4_HUMAN -p42 UP P28482 MK01_HUMAN -p42 UP Q9UQ80 PA2G4_HUMAN -p47 phox UP P14598 NCF1_HUMAN -p50 UP P19838 NFKB1_HUMAN -p52 HGNC 7795 NFKB2 -P53 family FPLX 000327 p53_family -p53 Family FPLX 000327 p53_family -p53 family FPLX 000327 p53_family -P53 UP P04637 P53_HUMAN -p53 UP P04637 P53_HUMAN -p53/p63/p73 family FPLX 000327 p53_family -p62 UP Q13501 SQSTM_HUMAN -p63 UP Q9H3D4 P63_HUMAN -p65 UP Q04206 TF65_HUMAN -p66Shc UP P29353-1 SHC1_HUMAN -p67 phox UP P19878 NCF2_HUMAN -p70 S6 kinase FPLX 000328 P70S6K -p70 UP P23443 KS6B1_HUMAN -P70RSK FPLX 000328 P70S6K -p70RSK FPLX 000328 P70S6K -p70S6 kinase UP P23443 KS6B1_HUMAN -P70S6K FPLX 000328 P70S6K -p70S6K UP P23443 KS6B1_HUMAN -p73 UP O15350 P73_HUMAN -p85 FPLX 000360 PI3K_p85 -p85alpha UP P27986 P85A_HUMAN -p85α UP P27986 P85A_HUMAN -p90RSK FPLX 000329 P90RSK -PA CHEBI CHEBI:16337 phosphatidic acid -PA PUBCHEM 8144759 . -paeoniflorin CHEBI CHEBI:7889 paeoniflorin -paeoniflorin PUBCHEM 442534 . -PAI-1 UP P05121 PAI1_HUMAN -PAK FPLX 000330 PAK -Pak FPLX 000330 PAK -PAK1 UP Q13153 PAK1_HUMAN -Pak1 UP Q13153 PAK1_HUMAN -Pak2 UP Q13177 PAK2_HUMAN -PAK4 UP O96013 PAK4_HUMAN -palmitate PUBCHEM 985 . -palmitate CHEBI CHEBI:15756 hexadecanoic acid -palmitate HMDB HMDB00220 . -PAR3 UP Q8TEW0 PARD3_HUMAN -Parkin UP O60260 PRKN_HUMAN -PARP genes FPLX 000331 PARP -PARP UP P09874 PARP1_HUMAN -Parp UP P09874 PARP1_HUMAN -PARP-1 UP P09874 PARP1_HUMAN -PARPs FPLX 000331 PARP -Parvin FPLX 000332 PARV -parvin FPLX 000332 PARV -Parvins FPLX 000332 PARV -parvins FPLX 000332 PARV -PATCHED FPLX 000333 Patched -Patched FPLX 000333 Patched -paxillin UP P49023 PAXI_HUMAN -PBX FPLX 000334 PBX -Pbx FPLX 000334 PBX -pbx FPLX 000334 PBX -PBXs FPLX 000334 PBX -Pca MESH D011471 Prostatic Neoplasms -PCNA UP P12004 PCNA_HUMAN -PD MESH D010300 Parkinson Disease -PD98509 CHEBI CHEBI:79091 EC 2.7.11.24 (mitogen-activated protein kinase) inhibitor -PDE 2 HGNC 8777 PDE2A -PDE 3 FPLX 000337 PDE3 -PDE FPLX 000335 PDE -PDE1 family FPLX 000336 PDE1 -PDE1 FPLX 000336 PDE1 -PDE3 family FPLX 000337 PDE3 -PDE3 FPLX 000337 PDE3 -PDE4 family FPLX 000338 PDE4 -PDE4 isoforms FPLX 000338 PDE4 -PDE4 FPLX 000338 PDE4 -PDE5 HGNC 8784 PDE5A -PDE6 family FPLX 000339 PDE6 -PDE6 FPLX 000339 PDE6 -PDE7 FPLX 000340 PDE7 -PDE8 FPLX 000341 PDE8 -PDEs FPLX 000335 PDE -PDGF CC FPLX 000350 PDGF_CC -PDGF DD FPLX 000351 PDGF_DD -PDGF FPLX 000342 PDGF -PDGF-AA FPLX 000347 PDGF_AA -PDGF-aa FPLX 000347 PDGF_AA -PDGF-AB FPLX 000348 PDGF_AB -PDGF-ab FPLX 000348 PDGF_AB -PDGF-BB FPLX 000349 PDGF_BB -PDGF-bb FPLX 000349 PDGF_BB -PDGF-CC FPLX 000350 PDGF_CC -PDGF-cc FPLX 000350 PDGF_CC -PDGF-DD FPLX 000351 PDGF_DD -PDGF-dd FPLX 000351 PDGF_DD -PDGFAA FPLX 000347 PDGF_AA -PDGFAB FPLX 000348 PDGF_AB -PDGFBB FPLX 000349 PDGF_BB -PDGFR FPLX 000343 PDGFR -PDGFR-AA FPLX 000344 PDGFR_AA -PDGFR-AB FPLX 000345 PDGFR_AB -PDGFR-alphaalpha FPLX 000344 PDGFR_AA -PDGFR-alphabeta FPLX 000345 PDGFR_AB -PDGFR-BB FPLX 000346 PDGFR_BB -PDGFR-betabeta FPLX 000346 PDGFR_BB -PDGFR-αα FPLX 000344 PDGFR_AA -PDGFR-αβ FPLX 000345 PDGFR_AB -PDGFR-ββ FPLX 000346 PDGFR_BB -PDGFRalpha UP P16234 PGFRA_HUMAN -PDGFRalphaalpha FPLX 000344 PDGFR_AA -PDGFRalphabeta FPLX 000345 PDGFR_AB -PDGFRbeta UP P09619 PGFRB_HUMAN -PDGFRbetabeta FPLX 000346 PDGFR_BB -PDGFRβ UP P09619 PGFRB_HUMAN -PDGFRα UP P16234 PGFRA_HUMAN -PDGFRαα FPLX 000344 PDGFR_AA -PDGFRαβ FPLX 000345 PDGFR_AB -PDGFRββ FPLX 000346 PDGFR_BB -PDH FPLX 000352 PDH -PDK FPLX 000353 PDK -PDK UP O15530 PDPK1_HUMAN -PDK1 UP O15530 PDPK1_HUMAN -PDKs FPLX 000353 PDK -PDPK1 UP O15530 PDPK1_HUMAN -PDT MESH D010778 Photochemotherapy -PEA-15 UP Q15121 PEA15_HUMAN -PERK UP Q9NZJ5 E2AK3_HUMAN -Peroxiredoxin FPLX 000388 PRDX -peroxiredoxin FPLX 000388 PRDX -Peroxiredoxins FPLX 000388 PRDX -peroxiredoxins FPLX 000388 PRDX -Pertussis toxin FPLX 000354 Pertussis_toxin -pertussis toxin FPLX 000354 Pertussis_toxin -PF-3758309 PUBCHEM 25227462 . -PF-3758309 CHEBI CHEBI:93751 N-[(1S)-2-(dimethylamino)-1-phenylethyl]-6,6-dimethyl-3-[(2-methyl-4-thieno[3,2-d]pyrimidinyl)amino]-1,4-dihydropyrrolo[3,4-c]pyrazole-5-carboxamide -PGC-1alpha UP Q9UBK2 PRGC1_HUMAN -PGC-1α UP Q9UBK2 PRGC1_HUMAN -PGE 2 CHEBI CHEBI:73965 prostaglandin E2-UM -PGE 2 PUBCHEM 161468 . -PGE2 UP P35408 PE2R4_HUMAN -phenformin PUBCHEM 8249 . -phenformin CHEBI CHEBI:8064 phenformin -PhK FPLX 000356 PhK -phosphatase FPLX 000357 Phosphatase -phosphatidylinositol 3-kinase FPLX 000358 PI3K -phosphatidylinositol CHEBI CHEBI:28874 phosphatidylinositol -phosphatidylinositol MESH D010716 Phosphatidylinositols -phospho-ERK1/2 FPLX 000161 ERK -Phosphodiesterase 1 FPLX 000336 PDE1 -phosphodiesterase 1 FPLX 000336 PDE1 -Phosphodiesterase 2 HGNC 8777 PDE2A -phosphodiesterase 2 HGNC 8777 PDE2A -Phosphodiesterase 3 FPLX 000337 PDE3 -phosphodiesterase 3 FPLX 000337 PDE3 -Phosphodiesterase 4 FPLX 000338 PDE4 -phosphodiesterase 4 FPLX 000338 PDE4 -Phosphodiesterase 5 HGNC 8784 PDE5A -phosphodiesterase 5 HGNC 8784 PDE5A -Phosphodiesterase 6 FPLX 000339 PDE6 -phosphodiesterase 6 FPLX 000339 PDE6 -Phosphodiesterase 7 FPLX 000340 PDE7 -phosphodiesterase 7 FPLX 000340 PDE7 -Phosphodiesterase 8 FPLX 000341 PDE8 -phosphodiesterase 8 FPLX 000341 PDE8 -Phosphodiesterase FPLX 000335 PDE -phosphodiesterase FPLX 000335 PDE -Phosphodiesterase-1 FPLX 000336 PDE1 -phosphodiesterase-1 FPLX 000336 PDE1 -Phosphodiesterase-2 HGNC 8777 PDE2A -phosphodiesterase-2 HGNC 8777 PDE2A -Phosphodiesterase-3 FPLX 000337 PDE3 -phosphodiesterase-3 FPLX 000337 PDE3 -Phosphodiesterase-4 FPLX 000338 PDE4 -phosphodiesterase-4 FPLX 000338 PDE4 -Phosphodiesterase-5 HGNC 8784 PDE5A -phosphodiesterase-5 HGNC 8784 PDE5A -Phosphodiesterase-6 FPLX 000339 PDE6 -phosphodiesterase-6 FPLX 000339 PDE6 -Phosphodiesterase-7 FPLX 000340 PDE7 -phosphodiesterase-7 FPLX 000340 PDE7 -Phosphodiesterase-8 FPLX 000341 PDE8 -phosphodiesterase-8 FPLX 000341 PDE8 -Phosphodiesterases FPLX 000335 PDE -phosphodiesterases FPLX 000335 PDE -Phospholipase A2 Group IV FPLX 000368 PLA2G4 -phospholipase A2 group-II FPLX 000367 PLA2G2 -phospholipase A2 group-IV FPLX 000368 PLA2G4 -phospholipase A2 FPLX 000366 PLA2 -Phospholipase C FPLX 000369 PLC -phospholipase C FPLX 000369 PLC -Phospholipase C-beta FPLX 000370 PLCB -phospholipase C-beta FPLX 000370 PLCB -Phospholipase C-delta FPLX 000371 PLCD -phospholipase C-delta FPLX 000371 PLCD -Phospholipase C-β FPLX 000370 PLCB -phospholipase C-β FPLX 000370 PLCB -Phospholipase C-δ FPLX 000371 PLCD -phospholipase C-δ FPLX 000371 PLCD -Phospholipase Cbeta FPLX 000370 PLCB -phospholipase Cbeta FPLX 000370 PLCB -Phospholipase Cdelta FPLX 000371 PLCD -phospholipase Cdelta FPLX 000371 PLCD -Phospholipase Cβ FPLX 000370 PLCB -phospholipase Cβ FPLX 000370 PLCB -Phospholipase Cδ FPLX 000371 PLCD -phospholipase Cδ FPLX 000371 PLCD -Phospholipase D FPLX 000373 PLD -phospholipase D FPLX 000373 PLD -Phospholipase-C FPLX 000369 PLC -phospholipase-C FPLX 000369 PLC -Phosphorylase kinase FPLX 000356 PhK -phosphorylase kinase FPLX 000356 PhK -PI 3-kinase FPLX 000358 PI3K -PI 3-kinases FPLX 000358 PI3K -PI CHEBI CHEBI:28874 phosphatidylinositol -PI MESH D010716 Phosphatidylinositols -PI3-kinase FPLX 000358 PI3K -PI3K inhibitor CHEBI CHEBI:84801 EC 2.7.1.127 (inositol-trisphosphate 3-kinase) inhibitor -PI3K p110 subunit FPLX 000359 PI3K_p110 -PI3K FPLX 000358 PI3K -PI3Kinase FPLX 000358 PI3K -PIK3C FPLX 000359 PI3K_p110 -PIK3CA UP P42336 PK3CA_HUMAN -PIK3R FPLX 000361 PIK3R_I -PIM FPLX 000362 PIM -Pin1 UP Q13526 PIN1_HUMAN -PIP CHEBI CHEBI:28765 phosphatidylinositol phosphate -PIP3 MESH C060974 phosphatidylinositol 3,4,5-triphosphate -PIP3 CHEBI CHEBI:60169 phosphatidylinositol trisphosphate -PK-A FPLX 000363 PKA -PKA catalytic subunit FPLX 000389 PRKAC -PKA catalytic subunits FPLX 000389 PRKAC -PKA regulatory subunit FPLX 000390 PRKAR -PKA regulatory subunits FPLX 000390 PRKAR -PKA FPLX 000363 PKA -PKB FPLX 000023 AKT -PKB-Akt FPLX 000023 AKT -PKB/Akt FPLX 000023 AKT -PKC FPLX 000364 PKC -PKCalpha UP P17252 KPCA_HUMAN -PKCdelta UP Q05655 KPCD_HUMAN -PKCepsilon UP Q02156 KPCE_HUMAN -PKCα UP P17252 KPCA_HUMAN -PKCε UP Q02156 KPCE_HUMAN -PKCδ UP Q05655 KPCD_HUMAN -PKG FPLX 000391 PRKG -PKI FPLX 000365 PKI -PKM2 UP P14618 KPYM_HUMAN -PKR UP P19525 E2AK2_HUMAN -PLA2G2 FPLX 000367 PLA2G2 -PLA2g2 FPLX 000367 PLA2G2 -PLA2G4 FPLX 000368 PLA2G4 -PLB UP P26678 PPLA_HUMAN -PLC FPLX 000369 PLC -PLC-gamma FPLX 000372 PLCG -PLC-gamma1 UP P19174 PLCG1_HUMAN -PLC-γ FPLX 000372 PLCG -PLC-γ1 UP P19174 PLCG1_HUMAN -PLCgamma1 UP P19174 PLCG1_HUMAN -PLCγ1 UP P19174 PLCG1_HUMAN -PLK1 UP P53350 PLK1_HUMAN -Plk1 UP P53350 PLK1_HUMAN -PLX PUBCHEM 42611257 . -PLX CHEBI CHEBI:63637 vemurafenib -PLX4032 PUBCHEM 42611257 . -PLX4032 CHEBI CHEBI:63637 vemurafenib -PML UP P29590 PML_HUMAN -Pol delta FPLX 000141 DNA_polymerase_delta -pol delta FPLX 000141 DNA_polymerase_delta -Pol I FPLX 000416 RNApo_I -Pol δ FPLX 000141 DNA_polymerase_delta -pol δ FPLX 000141 DNA_polymerase_delta -Poly(ADP-ribose) polymerase FPLX 000331 PARP -Poly(ADP-ribose) polymerases FPLX 000331 PARP -polycomb Repressive Complex (PRC) 1 FPLX 000386 PRC1_complex -Polycomb Repressive Complex 1 FPLX 000386 PRC1_complex -Polycomb repressive complex 1 FPLX 000386 PRC1_complex -polycomb repressive complex 1 FPLX 000386 PRC1_complex -Polycomb Repressive Complex 2 FPLX 000387 PRC2_complex -Polycomb repressive complex 2 FPLX 000387 PRC2_complex -polycomb repressive complex 2 FPLX 000387 PRC2_complex -Polycomb repressive complex PRC1 FPLX 000386 PRC1_complex -Polycomb repressive complex PRC2 FPLX 000387 PRC2_complex -Polycomb Repressive Complexes 1 FPLX 000386 PRC1_complex -Polycomb Repressive Complexes 2 FPLX 000387 PRC2_complex -Polycomb-repressive complex 1 FPLX 000386 PRC1_complex -Polycomb-repressive complex 2 FPLX 000387 PRC2_complex -PP1 regulator FPLX 000376 PPP1 -PP1 FPLX 000376 PPP1 -PP1C FPLX 000377 PPP1C -PP1c FPLX 000377 PPP1C -PP1R FPLX 000378 PPP1R -PP1r FPLX 000378 PPP1R -PP2 phosphatases FPLX 000379 PPP2 -PP2 CHEBI CHEBI:78331 PP2 -PP2 PUBCHEM 4878 . -PP2 FPLX 000379 PPP2 -PP242 PUBCHEM 135565635 . -PP242 CHEBI CHEBI:90679 torkinib -PP2A catalytic C subunit FPLX 000380 PPP2C -PP2A regulatory subunit A FPLX 000381 PPP2R_A -PP2A regulatory subunit B FPLX 000382 PPP2R_B -PP2A FPLX 000379 PPP2 -PP2A-C FPLX 000380 PPP2C -PP2Ac FPLX 000380 PPP2C -PP2B catalytic subunit FPLX 000384 PPP3C -PP2B FPLX 000383 PPP3 -PPAR FPLX 000375 PPAR -PPAR-gamma UP P37231 PPARG_HUMAN -PPAR-γ UP P37231 PPARG_HUMAN -PPARgamma UP P37231 PPARG_HUMAN -PPARγ UP P37231 PPARG_HUMAN -PPP1 FPLX 000376 PPP1 -PPP1C FPLX 000377 PPP1C -PR UP P06401 PRGR_HUMAN -PRAS40 UP Q96B36 AKTS1_HUMAN -pRB UP P06400 RB_HUMAN -pRb UP P06400 RB_HUMAN -PRC1 FPLX 000386 PRC1_complex -PRC1 UP O43663 PRC1_HUMAN -PRC2 FPLX 000387 PRC2_complex -PRKAA FPLX 000044 AMPK_alpha -PRKAB FPLX 000045 AMPK_beta -PRKAG FPLX 000046 AMPK_gamma -PRL-3 UP O75365 TP4A3_HUMAN -Profilin FPLX 000355 PFN -profilin FPLX 000355 PFN -Profilins FPLX 000355 PFN -profilins FPLX 000355 PFN -progesterone CHEBI CHEBI:17026 progesterone -progesterone PUBCHEM 5994 . -Proliferation GO GO:0008283 cell population proliferation -Proliferation MESH D049109 Cell Proliferation -proliferation GO GO:0008283 cell population proliferation -proliferation MESH D049109 Cell Proliferation -Propionyl-CoA carboxylase FPLX 000392 Propionyl_CoA_carboxylase -propionyl-CoA carboxylase FPLX 000392 Propionyl_CoA_carboxylase -prostaglandin E receptor FPLX 000395 PTGER -protease FPLX 000393 Protease -proteasome endopeptidase FPLX 000394 Proteasome -proteasome FPLX 000394 Proteasome -protein farnesyltransferase FPLX 000172 FNT -Protein kinase A catalytic subunit FPLX 000389 PRKAC -protein kinase A catalytic subunit FPLX 000389 PRKAC -Protein kinase A catalytic subunits FPLX 000389 PRKAC -protein kinase A catalytic subunits FPLX 000389 PRKAC -Protein kinase A regulatory subunit FPLX 000390 PRKAR -protein kinase A regulatory subunit FPLX 000390 PRKAR -Protein kinase A regulatory subunits FPLX 000390 PRKAR -protein kinase A regulatory subunits FPLX 000390 PRKAR -protein kinase A FPLX 000363 PKA -protein kinase C FPLX 000364 PKC -protein kinase G FPLX 000391 PRKG -protein phosphatase 2 FPLX 000379 PPP2 -protein phosphatase 2B FPLX 000383 PPP3 -proteolysis GO GO:0006508 proteolysis -proteolysis MESH D059748 Proteolysis -PTC UP P18502 PTC_DROME -Ptc UP P18502 PTC_DROME -ptc UP P18502 PTC_DROME -PTEN UP P60484 PTEN_HUMAN -Pten UP P60484 PTEN_HUMAN -PTP1B UP P18031 PTN1_HUMAN -PTX FPLX 000354 Pertussis_toxin -PTX3 HGNC 9692 PTX3 -PTX3 UP P26022 PTX3_HUMAN -PUMA UP Q96PG8 BBC3B_HUMAN -PYG FPLX 000396 PYG -Pyk2 UP Q14289 FAK2_HUMAN -pyruvate dehydrogenase (acetyl-transferring) FPLX 000352 PDH -Pyruvate dehydrogenase kinase FPLX 000353 PDK -pyruvate dehydrogenase kinase FPLX 000353 PDK -quercetin CHEBI CHEBI:16243 quercetin -quercetin PUBCHEM 5280343 . -RA PUBCHEM 5538 . -RA CHEBI CHEBI:26536 retinoic acid -RA HMDB HMDB06219 . -Rab GTPase FPLX 000397 RAB -Rab GTPases FPLX 000397 RAB -rab GTPases FPLX 000397 RAB -rab proteins FPLX 000397 RAB -RAB FPLX 000397 RAB -Rab FPLX 000397 RAB -rab FPLX 000397 RAB -Rabs FPLX 000397 RAB -RAC FPLX 000398 RAC -Rac UP P63000 RAC1_HUMAN -RAC1 UP P63000 RAC1_HUMAN -Rac1 UP P63000 RAC1_HUMAN -RAD51 UP Q06609 RAD51_HUMAN -Rad51 UP Q06609 RAD51_HUMAN -Rad52 UP P43351 RAD52_HUMAN -RAF inhibitors CHEBI CHEBI:75047 B-Raf inhibitor -RAF FPLX 000399 RAF -Raf FPLX 000399 RAF -Raf-1 UP P04049 RAF1_HUMAN -RAGE UP Q15109 RAGE_HUMAN -RAL family FPLX 000400 RAL -Ral family FPLX 000400 RAL -RAL guanine nucleotide dissociation stimulator like FPLX 000413 RGL -Ral guanine nucleotide dissociation stimulator like FPLX 000413 RGL -ral guanine nucleotide dissociation stimulator like FPLX 000413 RGL -RAL isoforms FPLX 000400 RAL -Ral isoforms FPLX 000400 RAL -RAL proteins FPLX 000400 RAL -Ral proteins FPLX 000400 RAL -RAL FPLX 000400 RAL -RAL HGNC 9839 RALA -RalA UP P11233 RALA_HUMAN -RALGDS-like FPLX 000413 RGL -RANKL UP O14788 TNF11_HUMAN -Rap guanine nucleotide exchange factor FPLX 000402 RAPGEF -Rap guanine nucleotide exchange factors FPLX 000402 RAPGEF -Rap1 FPLX 000401 RAP1 -Rapamycin PUBCHEM 5284616 . -Rapamycin CHEBI CHEBI:9168 sirolimus -rapamycin PUBCHEM 5284616 . -rapamycin CHEBI CHEBI:9168 sirolimus -RapGEFs FPLX 000402 RAPGEF -Raptor UP Q8N122 RPTOR_HUMAN -raptor UP Q8N122 RPTOR_HUMAN -RAR FPLX 000403 RAR -RAS association domain family FPLX 000410 RASSF -Ras association domain family FPLX 000410 RASSF -Ras GTPase FPLX 000404 RAS -RAS FPLX 000404 RAS -Ras FPLX 000404 RAS -RAS-association domain family FPLX 000410 RASSF -Ras-association domain family FPLX 000410 RASSF -RASA FPLX 000405 RASA -RASAL FPLX 000406 RASAL -RasGAP FPLX 000407 RasGAP -RasGAPs FPLX 000407 RasGAP -RASGRF FPLX 000408 RASGRF -RASGRP FPLX 000409 RASGRP -RASSF family FPLX 000410 RASSF -RASSF1A UP Q9NS23 RASF1_HUMAN -RB UP P06400 RB_HUMAN -Rb UP P06400 RB_HUMAN -RB1 UP P06400 RB_HUMAN -Rb1 UP P06400 RB_HUMAN -receptor tyrosine kinase-like orphan receptor FPLX 000420 ROR -receptor tyrosine kinase-like orphan receptors FPLX 000420 ROR -REDD1 UP Q9NX09 DDIT4_HUMAN -regulatory A subunit of PP2A FPLX 000381 PPP2R_A -regulatory B subunit of PP2A FPLX 000382 PPP2R_B -regulatory family X FPLX 000412 RFX -regulatory myosin light chain FPLX 000298 MYL_regulatory -regulatory subunit of calcineurin FPLX 000385 PPP3R -RelA UP Q04206 TF65_HUMAN -replication factor C FPLX 000411 RFC -Replication protein A FPLX 000421 RPA -replication protein A FPLX 000421 RPA -RES PUBCHEM 5281611 . -Resveratrol PUBCHEM 445154 . -Resveratrol CHEBI CHEBI:27881 resveratrol -resveratrol PUBCHEM 445154 . -resveratrol CHEBI CHEBI:27881 resveratrol -RET UP P07949 RET_HUMAN -retinoblastoma protein UP P06400 RB_HUMAN -retinoic acid receptors FPLX 000403 RAR -retinoid X receptors FPLX 000424 RXR -retinoid-X receptor FPLX 000424 RXR -RF-C FPLX 000411 RFC -RF-X FPLX 000412 RFX -RFC FPLX 000411 RFC -RFX family FPLX 000412 RFX -RFX proteins FPLX 000412 RFX -RFX FPLX 000412 RFX -Rheb UP Q15382 RHEB_HUMAN -Rho family FPLX 000414 RHO -RHO FPLX 000414 RHO -Rho UP P61586 RHOA_HUMAN -Rho-GDI FPLX 000415 RhoGDI -RhoA UP P61586 RHOA_HUMAN -RhoB UP P62745 RHOB_HUMAN -RhoC UP P08134 RHOC_HUMAN -RHOGDI FPLX 000415 RhoGDI -RhoGDI FPLX 000415 RhoGDI -rhoGDI FPLX 000415 RhoGDI -RhoGDIs FPLX 000415 RhoGDI -ribosomal protein S6 UP P62753 RS6_HUMAN -ribosomal protein S6 IP IPR000529 . -RICTOR UP Q6R327 RICTR_HUMAN -Rictor UP Q6R327 RICTR_HUMAN -RIG-I UP O95786 DDX58_HUMAN -RIP1 UP Q13546 RIPK1_HUMAN -RKIP UP P30086 PEBP1_HUMAN -RNA polymerase 1 FPLX 000416 RNApo_I -RNA polymerase I FPLX 000416 RNApo_I -RNA polymerase II FPLX 000417 RNApo_II -RNAP II FPLX 000417 RNApo_II -ROCK FPLX 000419 ROCK -ROCK1 UP Q13464 ROCK1_HUMAN -ROCK2 UP O75116 ROCK2_HUMAN -ROR FPLX 000420 ROR -RORs FPLX 000420 ROR -ROS MESH D017382 Reactive Oxygen Species -ROS UP P08922 ROS1_HUMAN -rosiglitazone CHEBI CHEBI:50122 rosiglitazone -rosiglitazone PUBCHEM 77999 . -rottlerin CHEBI CHEBI:8899 rottlerin -rottlerin PUBCHEM 5281847 . -RPA FPLX 000421 RPA -rPKA FPLX 000390 PRKAR -RPS6KA FPLX 000329 P90RSK -RSK FPLX 000422 RSK -RSK2 UP P51812 KS6A3_HUMAN -RTA UP O43251 RFOX2_HUMAN -RTKs FPLX 000423 RTK -RUNX2 UP Q13950 RUNX2_HUMAN -rutin CHEBI CHEBI:28527 rutin -rutin PUBCHEM 5280805 . -RXR FPLX 000424 RXR -S100 FPLX 000425 S100 -S100A FPLX 000426 S100A -S100a FPLX 000426 S100A -S1P receptor FPLX 000427 S1PR -S1PR FPLX 000427 S1PR -S6 UP P62753 RS6_HUMAN -S6 IP IPR000529 . -S6K FPLX 000328 P70S6K -S6K1 UP P23443 KS6B1_HUMAN -SAA FPLX 000428 SAA -SAC GO GO:0033316 meiotic spindle assembly checkpoint -SAF-1 UP P56270 MAZ_HUMAN -SAHA PUBCHEM 5311 . -SAHA CHEBI CHEBI:45716 vorinostat -SAHA CHEMBL CHEMBL98 . -sarcoplasmic/endoplasmic reticulum calcium ATPase FPLX 000430 SERCA -SB203580 PUBCHEM 176155 . -SB203580 CHEBI CHEBI:90705 SB 203580 -SCF UP P21583 SCF_HUMAN -senescence GO GO:0090398 cellular senescence -senescence MESH D016922 Cellular Senescence -SERCA FPLX 000430 SERCA -SERCAs FPLX 000430 SERCA -SFK FPLX 000451 SRC -SFN CHEBI CHEBI:47807 sulforaphane -SFN PUBCHEM 5350 . -Shc family FPLX 000432 SHC -SHC FPLX 000432 SHC -Shc FPLX 000432 SHC -shikonin CHEBI CHEBI:81068 Shikonin -shikonin PUBCHEM 479503 . -SHP-2 UP Q06124 PTN11_HUMAN -SHP2 UP Q06124 PTN11_HUMAN -Shp2 UP Q06124 PTN11_HUMAN -Sialytransferase FPLX 000202 GTF_family_29 -Sialytransferases FPLX 000202 GTF_family_29 -sialytransferase FPLX 000202 GTF_family_29 -sialytransferases FPLX 000202 GTF_family_29 -signal transduction GO GO:0007165 signal transduction -signal transduction MESH D015398 Signal Transduction -simvastatin CHEBI CHEBI:9150 simvastatin -simvastatin PUBCHEM 54454 . -SIRT1 UP Q96EB6 SIR1_HUMAN -Sirt1 UP Q96EB6 SIR1_HUMAN -Skp2 UP Q13309 SKP2_HUMAN -SLC2 FPLX 000434 SLC2A -slow myosin FPLX 000299 MYL_slow -SLP-76 UP Q13094 LCP2_HUMAN -SLRP FPLX 000435 SLRP -SLRPs FPLX 000435 SLRP -SLRR FPLX 000435 SLRP -SLRRs FPLX 000435 SLRP -SMAD 2/3 FPLX 000443 SMAD2_3 -SMAD FPLX 000441 SMAD -Smad FPLX 000441 SMAD -smad FPLX 000441 SMAD -Smad2 UP Q15796 SMAD2_HUMAN -smad2 UP Q15796 SMAD2_HUMAN -SMAD2/3 FPLX 000443 SMAD2_3 -Smad2/3 FPLX 000443 SMAD2_3 -Smad3 UP P84022 SMAD3_HUMAN -Smad4 UP Q13485 SMAD4_HUMAN -small HSPs FPLX 000245 HSPB -small leucine rich proteoglycan family FPLX 000435 SLRP -small leucine rich proteoglycan FPLX 000435 SLRP -small leucine rich proteoglycans FPLX 000435 SLRP -small leucine-rich proteoglycan family FPLX 000435 SLRP -small leucine-rich proteoglycan FPLX 000435 SLRP -small leucine-rich proteoglycans FPLX 000435 SLRP -SMC1 FPLX 000444 SMC1 -Smc1 FPLX 000444 SMC1 -SNAI family FPLX 000446 SNAI -SNAI FPLX 000446 SNAI -Snail UP O95863 SNAI1_HUMAN -SOD FPLX 000447 SOD -Sorafenib PUBCHEM 216239 . -Sorafenib CHEBI CHEBI:50924 sorafenib -sorafenib PUBCHEM 216239 . -sorafenib CHEBI CHEBI:50924 sorafenib -SOS FPLX 000448 SOS -Sos-1 UP Q07889 SOS1_HUMAN -SOS1 UP Q07889 SOS1_HUMAN -Sos1 UP Q07889 SOS1_HUMAN -SOX2 UP P48431 SOX2_HUMAN -Sp1 UP P08047 SP1_HUMAN -SP600125 PUBCHEM 8515 . -SP600125 CHEBI CHEBI:90695 anthra[1,9-cd]pyrazol-6(2H)-one -SPC CHEBI CHEBI:17689 sphingosine-1-phosphocholine -SPC PUBCHEM 9847290 . -Sphingosine 1-phosphate receptor FPLX 000427 S1PR -sphingosine-1-phosphate receptors FPLX 000427 S1PR -SPRED FPLX 000449 SPRED -SPRY FPLX 000450 SPRY -SR Ca(2+)-ATPase FPLX 000430 SERCA -Src family kinase FPLX 000451 SRC -Src family FPLX 000451 SRC -src kinases FPLX 000451 SRC -SRC UP P12931 SRC_HUMAN -Src UP P12931 SRC_HUMAN -SRC-family kinases FPLX 000451 SRC -Src-kinases FPLX 000451 SRC -SREBF family FPLX 000452 SREBF -SREBF FPLX 000452 SREBF -SRF UP P11831 SRF_HUMAN -StAR HGNC 11359 STAR -StAR UP P49675 STAR_HUMAN -STAT FPLX 000453 STAT -STAT1 UP P42224 STAT1_HUMAN -STAT3 UP P40763 STAT3_HUMAN -Stat3 UP P40763 STAT3_HUMAN -STAT5 FPLX 000454 STAT5 -Stat5 FPLX 000454 STAT5 -STATs FPLX 000453 STAT -Staurosporine PUBCHEM 44259 . -Staurosporine CHEBI CHEBI:15738 staurosporine -staurosporine PUBCHEM 44259 . -staurosporine CHEBI CHEBI:15738 staurosporine -stearoyl-CoA 9-desaturase FPLX 000429 SCD -Stearoyl-CoA desaturase FPLX 000429 SCD -stearoyl-CoA desaturase FPLX 000429 SCD -sterol regulatory element binding protein FPLX 000452 SREBF -sterol regulatory element-binding factor FPLX 000452 SREBF -STING UP Q86WV6 STING_HUMAN -STT3 FPLX 000455 STT3 -STZ PUBCHEM 29327 . -STZ UP Q11206 SIA4C_HUMAN -succinate dehydrogenase (ubiquinone) FPLX 000502 ETC_complex_II -succinate dehydrogenase FPLX 000502 ETC_complex_II -Sulfonylurea Receptor FPLX 000456 Sulfonylurea_receptor -sulfonylurea receptor FPLX 000456 Sulfonylurea_receptor -sulfonylurea receptors FPLX 000456 Sulfonylurea_receptor -sulforaphane PUBCHEM 5350 . -sulforaphane CHEBI CHEBI:47807 sulforaphane -superoxide CHEBI CHEBI:18421 superoxide -superoxide PUBCHEM 5359597 . -SUR FPLX 000456 Sulfonylurea_receptor -Survivin UP O15392 BIRC5_HUMAN -survivin UP O15392 BIRC5_HUMAN -SWI and SNF complex FPLX 000457 SWI_SNF -SWI/SNF complex FPLX 000457 SWI_SNF -SWI/SNF FPLX 000457 SWI_SNF -SWI/SNF-like FPLX 000457 SWI_SNF -Syk UP P43405 KSYK_HUMAN -SYNJ2 UP O15056 SYNJ2_HUMAN -T-cell factor (TCF)/lymphoid enhancer factor FPLX 000460 TCF_LEF -TAK1 UP O43318 M3K7_HUMAN -TAK165 PUBCHEM 6444692 . -tamoxifen PUBCHEM 2733526 . -tamoxifen CHEBI CHEBI:41774 tamoxifen -TAP transporter FPLX 000459 TAP -TAP FPLX 000459 TAP -TAp73 UP O15350 P73_HUMAN -TAS-116 PUBCHEM 67501411 . -Tat UP P04608 TAT_HV1H2 -tau UP P10636 TAU_HUMAN -Tax UP P03409 TAX_HTL1A -TBK1 UP Q9UHD2 TBK1_HUMAN -TCF FPLX 000460 TCF_LEF -Tcf FPLX 000460 TCF_LEF -Tcf/Lef FPLX 000460 TCF_LEF -TCR FPLX 000461 TCR -TDRG1 UP Q3Y452 TDRG1_HUMAN -telomerase UP O14746 TERT_HUMAN -Temozolomide CHEBI CHEBI:72564 temozolomide -Temozolomide PUBCHEM 5394 . -temozolomide CHEBI CHEBI:72564 temozolomide -temozolomide PUBCHEM 5394 . -Tenascin FPLX 000473 TN -tenascin FPLX 000473 TN -TFDP FPLX 000464 TFDP -TFIIE FPLX 000196 GTF2E -TFIIF FPLX 000197 GTF2F -TGF beta receptor FPLX 000466 TGFBR -TGF beta FPLX 000465 TGFB -TGF β receptor FPLX 000466 TGFBR -TGF β FPLX 000465 TGFB -TGF-alpha UP P01135 TGFA_HUMAN -TGF-b FPLX 000465 TGFB -TGF-beta family FPLX 000465 TGFB -TGF-beta receptor FPLX 000466 TGFBR -TGF-beta receptors FPLX 000466 TGFBR -TGF-beta FPLX 000465 TGFB -TGF-beta1 UP P01137 TGFB1_HUMAN -TGF-β receptor FPLX 000466 TGFBR -TGF-β receptors FPLX 000466 TGFBR -TGF-β FPLX 000465 TGFB -TGF-α UP P01135 TGFA_HUMAN -TGF-β1 UP P01137 TGFB1_HUMAN -TGFalpha UP P01135 TGFA_HUMAN -TGFB family FPLX 000465 TGFB -TGFB FPLX 000465 TGFB -TGFbeta FPLX 000465 TGFB -TGFbeta1 UP P01137 TGFB1_HUMAN -TGFBR family FPLX 000466 TGFBR -TGFBR FPLX 000466 TGFBR -TGFβ receptor FPLX 000466 TGFBR -TGFβ receptors FPLX 000466 TGFBR -TGFβ FPLX 000465 TGFB -TGFα UP P01135 TGFA_HUMAN -TGFβ1 UP P01137 TGFB1_HUMAN -thapsigargin PUBCHEM 446378 . -thapsigargin CHEBI CHEBI:9516 thapsigargin -Thioredoxin reductase FPLX 000488 TXNRD -thioredoxin reductase FPLX 000488 TXNRD -Thioredoxin FPLX 000487 TXN -thioredoxin FPLX 000487 TXN -Thioredoxin UP P10599 THIO_HUMAN -thioredoxin UP P10599 THIO_HUMAN -thioredoxins FPLX 000487 TXN -thrombin IP IPR003966 . -thrombin UP P00734 THRB_HUMAN -thrombin-anti-thrombin III complexes FPLX 000469 Thrombin_antithrombin -thrombospondin protein FPLX 000467 THBS -Thrombospondin FPLX 000467 THBS -thrombospondin FPLX 000467 THBS -Thrombospondins FPLX 000467 THBS -thrombospondins FPLX 000467 THBS -thyroid hormone receptor FPLX 000468 THR -TIAM FPLX 000470 TIAM -TIAM1 UP Q13009 TIAM1_HUMAN -Tiam1 UP Q13009 TIAM1_HUMAN -TIAM2 UP Q8IVF5 TIAM2_HUMAN -Tiam2 UP Q8IVF5 TIAM2_HUMAN -TIF-IB FPLX 000471 TIF_IB -tipifarnib PUBCHEM 159324 . -tipifarnib CHEBI CHEBI:141969 tipifarnib -tissue kallikrein FPLX 000271 KLK -tissue kallikreins FPLX 000271 KLK -TLR FPLX 000472 TLR -TLR2 UP O60603 TLR2_HUMAN -TLR4 UP O00206 TLR4_HUMAN -TMZ CHEBI CHEBI:72564 temozolomide -TMZ PUBCHEM 5394 . -TN-C FPLX 000478 Troponin_C -TnC FPLX 000478 Troponin_C -TNF UP P01375 TNFA_HUMAN -TNF-alpha UP P01375 TNFA_HUMAN -TNF-R superfamily FPLX 000475 TNFRSF -TNF-receptor family FPLX 000475 TNFRSF -TNF-α UP P01375 TNFA_HUMAN -TNFalpha UP P01375 TNFA_HUMAN -TNFR family FPLX 000475 TNFRSF -TNFR subfamily FPLX 000475 TNFRSF -TNFR superfamily members FPLX 000475 TNFRSF -TNFR superfamily receptors FPLX 000475 TNFRSF -TNFR superfamily FPLX 000475 TNFRSF -TNFR FPLX 000475 TNFRSF -TNFR1 UP P19438 TNR1A_HUMAN -TNFα UP P01375 TNFA_HUMAN -topoisomerase II FPLX 000476 TOP2 -TORC1 FPLX 000293 mTORC1 -TORC2 FPLX 000294 mTORC2 -TP53 UP P04637 P53_HUMAN -TPA PUBCHEM 27924 . -TPA CHEBI CHEBI:37537 phorbol 13-acetate 12-myristate -Tpl2 HGNC 6860 MAP3K8 -TPNI FPLX 000479 Troponin_I -TPNT FPLX 000480 Troponin_T -TQ PUBCHEM 10281 . -TQ CHEBI CHEBI:113532 2-methyl-5-propan-2-ylcyclohexa-2,5-diene-1,4-dione -TRAF2 UP Q12933 TRAF2_HUMAN -TRAF3 UP Q13114 TRAF3_HUMAN -TRAF6 UP Q9Y4K3 TRAF6_HUMAN -TRAIL UP P50591 TNF10_HUMAN -trametinib CHEBI CHEBI:75998 trametinib -trametinib PUBCHEM 11707110 . -Transcription factor AP-2 FPLX 000463 TFAP2 -transcription factor AP-2 FPLX 000463 TFAP2 -transcription factor DP FPLX 000464 TFDP -transcription factor II E FPLX 000196 GTF2E -transcription factor II F FPLX 000197 GTF2F -transcription factor IIE FPLX 000196 GTF2E -transcription factor IIF FPLX 000197 GTF2F -transcription GO GO:0006351 transcription, DNA-templated -transcription MESH D014158 Transcription, Genetic -transcriptional cofactor complex CRSP FPLX 000122 CRSP -transforming growth factor beta FPLX 000465 TGFB -transforming growth factor β FPLX 000465 TGFB -transforming growth factor-beta FPLX 000465 TGFB -transforming growth factor-β FPLX 000465 TGFB -translation GO GO:0006412 translation -translation MESH D014176 Protein Biosynthesis -transport GO GO:0006810 transport -trastuzumab MESH D000068878 Trastuzumab -trastuzumab CHEMBL 1201585 . -TRiC FPLX 000085 CCT_complex -TRIM UP Q6PIZ9 TRAT1_HUMAN -Trk receptor FPLX 000321 NTRK -trk receptor FPLX 000321 NTRK -Trk receptors FPLX 000321 NTRK -trk receptors FPLX 000321 NTRK -TrkA UP P04629 NTRK1_HUMAN -TrkB UP Q16620 NTRK2_HUMAN -troponin C FPLX 000478 Troponin_C -troponin complex FPLX 000477 Troponin -troponin I FPLX 000479 Troponin_I -troponin T FPLX 000480 Troponin_T -troponin FPLX 000477 Troponin -troponins FPLX 000477 Troponin -trypsin CHEBI CHEBI:9765 Trypsin -Tryptase FPLX 000481 Tryptase -tryptase FPLX 000481 Tryptase -tryptases FPLX 000481 Tryptase -TSA PUBCHEM 444732 . -TSA CHEBI CHEBI:46024 trichostatin A -TSC FPLX 000482 TSC -TSC1 UP Q92574 TSC1_HUMAN -TSC2 UP P49815 TSC2_HUMAN -TUBA FPLX 000483 TUBA -TUBB FPLX 000484 TUBB -tuberin UP P49815 TSC2_HUMAN -tubulin alpha chain FPLX 000483 TUBA -tubulin beta chain FPLX 000484 TUBB -tubulin beta FPLX 000484 TUBB -tubulin delta HGNC 16811 TUBD1 -tubulin epsilon HGNC 20775 TUBE1 -tubulin gamma FPLX 000485 TUBG -tubulin α chain FPLX 000483 TUBA -tubulin β chain FPLX 000484 TUBB -tubulin β FPLX 000484 TUBB -tubulin γ FPLX 000485 TUBG -tubulin δ HGNC 16811 TUBD1 -tubulin ε HGNC 20775 TUBE1 -tubulin FPLX 000486 Tubulin -tumor necrosis factor UP P01375 TNFA_HUMAN -tumorigenesis MESH D063646 Carcinogenesis -tunicamycin CHEBI CHEBI:29699 tunicamycin -tunicamycin PUBCHEM 56927680 . -type 2 phosphatidic acid phosphatase FPLX 000374 PPAP2 -type 2 phosphatidic acid phosphatases FPLX 000374 PPAP2 -type 4 cyclic nucleotide phosphodiesterase FPLX 000338 PDE4 -Type I collagen FPLX 000109 COL1 -type I collagen FPLX 000109 COL1 -type II phosphatidic acid phosphatase FPLX 000374 PPAP2 -type II phosphatidic acid phosphatases FPLX 000374 PPAP2 -type V collagen FPLX 000111 COL5 -type-V collagen FPLX 000111 COL5 -U0126 PUBCHEM 3006531 . -U0126 CHEBI CHEBI:90693 U0126 -Ub FPLX 000490 Ubiquitin -ub FPLX 000490 Ubiquitin -UBE2 FPLX 000489 UBE2 -ubiquitin conjugating enzyme FPLX 000489 UBE2 -Ubiquitin FPLX 000490 Ubiquitin -ubiquitin FPLX 000490 Ubiquitin -ubiquitin-conjugating enzymes FPLX 000489 UBE2 -UGT FPLX 000492 UGT -uPA UP P00749 UROK_HUMAN -uPAR UP Q03405 UPAR_HUMAN -vascular endothelial growth factor FPLX 000495 VEGF -VAV family FPLX 000494 VAV -Vav FPLX 000494 VAV -Vav1 UP P15498 VAV_HUMAN -VCAM-1 UP P19320 VCAM1_HUMAN -VEGF receptor FPLX 000496 VEGFR -VEGF receptors FPLX 000496 VEGFR -VEGF FPLX 000495 VEGF -VEGF-A UP P15692 VEGFA_HUMAN -VEGFR ligand FPLX 000496 VEGFR -VEGFR FPLX 000496 VEGFR -VEGFR-2 UP P35968 VGFR2_HUMAN -VEGFR2 UP P35968 VGFR2_HUMAN -VEGFRs FPLX 000496 VEGFR -Vemurafenib PUBCHEM 42611257 . -Vemurafenib CHEBI CHEBI:63637 vemurafenib -vemurafenib PUBCHEM 42611257 . -vemurafenib CHEBI CHEBI:63637 vemurafenib -vitronectin receptor (integrin) FPLX 000261 Integrins -VLDL CHEBI CHEBI:39027 very-low-density lipoprotein -vorinostat PUBCHEM 5311 . -vorinostat CHEBI CHEBI:45716 vorinostat -VPA PUBCHEM 3121 . -VPA CHEBI CHEBI:39867 valproic acid -Vpr UP P05928 VPR_HV1BR -Vpu UP P05919 VPU_HV1H2 -WA PUBCHEM 265237 . -WA CHEBI CHEBI:69120 withaferin A -wild type c-Cbl UP P22681 CBL_HUMAN -WNT FPLX 000497 Wnt -Wnt FPLX 000497 Wnt -Wnt5a UP P41221 WNT5A_HUMAN -wogonin PUBCHEM 5281703 . -wogonin CHEBI CHEBI:10043 wogonin -XIAP UP P98170 XIAP_HUMAN -XYLT FPLX 000185 GCNT -Xylosyltransferase FPLX 000185 GCNT -Xylosyltransferases FPLX 000185 GCNT -xylosyltransferase FPLX 000185 GCNT -xylosyltransferases FPLX 000185 GCNT -Y box binding protein FPLX 000498 YBX -Y-box-binding protein FPLX 000498 YBX -YAP UP P46937 YAP1_HUMAN -YAP1 UP P46937 YAP1_HUMAN -YBX protein family FPLX 000498 YBX -ZEB1 UP P37275 ZEB1_HUMAN -Zeb1 UP P37275 ZEB1_HUMAN -β adrenergic receptor kinase FPLX 000022 ADRBK -α catenin FPLX 000126 CTNNA -β interferons FPLX 000247 IFNB -γ secretase FPLX 000181 Gamma_secretase -α tubulin FPLX 000483 TUBA -γ tubulin FPLX 000485 TUBG -α(2)-adrenoceptors FPLX 000020 ADRA2 -α(2)-ARs FPLX 000020 ADRA2 -α-adrenergic receptor FPLX 000019 ADRA -β-adrenergic receptor FPLX 000021 ADRB -α-adrenoreceptor FPLX 000019 ADRA -β-adrenoreceptor FPLX 000021 ADRB -α-adrenoreceptors FPLX 000019 ADRA -γ-aminobutyric-acid A receptor FPLX 000179 GABR -α-catenin FPLX 000126 CTNNA -β-catenin UP P35222 CTNB1_HUMAN -β-TrCP UP Q9Y297 FBW1A_HUMAN -γ-tubulin FPLX 000485 TUBG -δ-tubulin HGNC 16811 TUBD1 -ε-tubulin HGNC 20775 TUBE1 -α1β1γ1 FPLX 000032 AMPK_A1B1G1 -α1β1γ2 FPLX 000033 AMPK_A1B1G2 -α1β1γ3 FPLX 000034 AMPK_A1B1G3 -α1β2γ1 FPLX 000035 AMPK_A1B2G1 -α1β2γ2 FPLX 000036 AMPK_A1B2G2 -α2-AR FPLX 000020 ADRA2 -α2β1γ1 FPLX 000038 AMPK_A2B1G1 -α2β2γ1 FPLX 000041 AMPK_A2B2G1 -α2β2γ2 FPLX 000042 AMPK_A2B2G2 -α2β2γ3 FPLX 000043 AMPK_A2B2G3 -βAR FPLX 000021 ADRB -βARK FPLX 000022 ADRBK -receptor GO GO:0038023 signaling receptor activity -eGFR MESH D005919 Glomerular Filtration Rate -CDK1/2 FPLX 000093 CDK1_2 -cdk1/2 FPLX 000093 CDK1_2 -Cdk1/2 FPLX 000093 CDK1_2 -Chk1/2 FPLX 000098 CHEK -chromosomal instability MESH D043171 Chromosomal Instability -chromosomal instability NCIT C48195 . -chromosomal instabiliy MESH D043171 Chromosomal Instability -chromosomal instabiliy NCIT C48195 . -CIN MESH D043171 Chromosomal Instability -CIN NCIT C48195 . -CycK HGNC 1596 CCNK -CycK1 HGNC 1596 CCNK -dinaciclib PUBCHEM 46926350 . -dinaciclib CHEMBL CHEMBL2103840 . -dinaciclib CHEBI CHEBI:95060 2-[(2S)-1-[3-ethyl-7-[(1-oxido-3-pyridin-1-iumyl)methylamino]-5-pyrazolo[1,5-a]pyrimidinyl]-2-piperidinyl]ethanol -Dinaciclib PUBCHEM 46926350 . -Dinaciclib CHEMBL CHEMBL2103840 . -Dinaciclib CHEBI CHEBI:95060 2-[(2S)-1-[3-ethyl-7-[(1-oxido-3-pyridin-1-iumyl)methylamino]-5-pyrazolo[1,5-a]pyrimidinyl]-2-piperidinyl]ethanol -Ebp1 HGNC 8550 PA2G4 -EBP1 HGNC 8550 PA2G4 -erbB FPLX 000160 ERBB -Fer-1 PUBCHEM 4068248 . -HK2 HGNC 4923 HK2 -NLE CHEBI CHEBI:38473 azadirachtin -PD-1 UP Q15116 PDCD1_HUMAN -PD-1 HGNC 8760 PDCD1 -Se PUBCHEM 6326970 . -Se CHEBI CHEBI:27568 selenium atom -THZ531 PUBCHEM 118025540 . -THZ531 CHEBI CHEBI:143122 THZ531 -Hh FPLX 000226 Hedgehog -SIK FPLX 000433 SIK -salt inducible kinase FPLX 000433 SIK -Sik UP Q64434 PTK6_MOUSE -DYRK FPLX 000146 DYRK -Augmin FPLX 000061 Augmin -HAUS FPLX 000061 Augmin -HAUS complex FPLX 000061 Augmin -CRTC FPLX 000123 CRTC diff --git a/famplex/resources/metadata.json b/famplex/resources/metadata.json index 0e66bfaf3..8e1c57a8e 100644 --- a/famplex/resources/metadata.json +++ b/famplex/resources/metadata.json @@ -1,5 +1,5 @@ { - "Time Exported": "Sun Jul 21 17:49:55 2019", + "Time Exported": "Sun Jul 21 18:47:42 2019", "Unlabelled Groundings": [ { "db": "CHEMBL", @@ -105,6 +105,10 @@ "db": "LNCRNADB", "db_id": "HOTAIR" }, + { + "db": "MESH", + "db_id": "0007249" + }, { "db": "NCIT", "db_id": "C16404" @@ -704,6 +708,22 @@ { "db": "PUBCHEM", "db_id": "9887712" + }, + { + "db": "UP", + "db_id": "I1YP21" + }, + { + "db": "UP", + "db_id": "P0CW71" + }, + { + "db": "UP", + "db_id": "Q157B2" + }, + { + "db": "UP", + "db_id": "U3LIR9" } ], "Unlabelled Relations": [] diff --git a/famplex/resources/relations.csv b/famplex/resources/relations.csv new file mode 100644 index 000000000..8162d5939 --- /dev/null +++ b/famplex/resources/relations.csv @@ -0,0 +1,2784 @@ +HGNC,3288,EIF4EBP1,isa,FPLX,000154,EIF4EBP +HGNC,3289,EIF4EBP2,isa,FPLX,000154,EIF4EBP +HGNC,3290,EIF4EBP3,isa,FPLX,000154,EIF4EBP +HGNC,129,ACTA1,isa,FPLX,000009,Actin +HGNC,130,ACTA2,isa,FPLX,000009,Actin +HGNC,132,ACTB,isa,FPLX,000009,Actin +HGNC,143,ACTC1,isa,FPLX,000009,Actin +HGNC,144,ACTG1,isa,FPLX,000009,Actin +HGNC,145,ACTG2,isa,FPLX,000009,Actin +FPLX,000011,Activin_A,isa,FPLX,000010,Activin +FPLX,000012,Activin_AB,isa,FPLX,000010,Activin +FPLX,000013,Activin_B,isa,FPLX,000010,Activin +FPLX,000257,Inhibin_A,isa,FPLX,000256,Inhibin +FPLX,000258,Inhibin_B,isa,FPLX,000256,Inhibin +HGNC,6066,INHBA,partof,FPLX,000011,Activin_A +HGNC,6066,INHBA,partof,FPLX,000012,Activin_AB +HGNC,6067,INHBB,partof,FPLX,000012,Activin_AB +HGNC,6067,INHBB,partof,FPLX,000013,Activin_B +HGNC,6065,INHA,partof,FPLX,000257,Inhibin_A +HGNC,6066,INHBA,partof,FPLX,000257,Inhibin_A +HGNC,6065,INHA,partof,FPLX,000258,Inhibin_B +HGNC,6067,INHBB,partof,FPLX,000258,Inhibin_B +HGNC,391,AKT1,isa,FPLX,000023,AKT +HGNC,392,AKT2,isa,FPLX,000023,AKT +HGNC,393,AKT3,isa,FPLX,000023,AKT +FPLX,000044,AMPK_alpha,partof,FPLX,000031,AMPK 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+HGNC,18854,CREB3L4,isa,FPLX,000120,CREB +HGNC,2352,CREM,isa,FPLX,000120,CREB +HGNC,783,ATF1,isa,FPLX,000120,CREB +HGNC,784,ATF2,isa,FPLX,000120,CREB +HGNC,1577,CCNA1,isa,FPLX,000131,Cyclin_A +HGNC,1578,CCNA2,isa,FPLX,000131,Cyclin_A +HGNC,1579,CCNB1,isa,FPLX,000130,Cyclin +HGNC,1580,CCNB2,isa,FPLX,000130,Cyclin +HGNC,18709,CCNB3,isa,FPLX,000130,Cyclin +HGNC,1581,CCNC,isa,FPLX,000130,Cyclin +HGNC,1582,CCND1,isa,FPLX,000132,Cyclin_D +HGNC,1583,CCND2,isa,FPLX,000132,Cyclin_D +HGNC,1585,CCND3,isa,FPLX,000132,Cyclin_D +HGNC,1589,CCNE1,isa,FPLX,000133,Cyclin_E +HGNC,1590,CCNE2,isa,FPLX,000133,Cyclin_E +HGNC,1591,CCNF,isa,FPLX,000130,Cyclin +HGNC,1592,CCNG1,isa,FPLX,000130,Cyclin +HGNC,1593,CCNG2,isa,FPLX,000130,Cyclin +HGNC,1594,CCNH,isa,FPLX,000130,Cyclin +HGNC,1595,CCNI,isa,FPLX,000130,Cyclin +HGNC,33869,CCNI2,isa,FPLX,000130,Cyclin +HGNC,23434,CCNJ,isa,FPLX,000130,Cyclin +HGNC,25876,CCNJL,isa,FPLX,000130,Cyclin +HGNC,1596,CCNK,isa,FPLX,000130,Cyclin +HGNC,20569,CCNL1,isa,FPLX,000130,Cyclin +HGNC,20570,CCNL2,isa,FPLX,000130,Cyclin +HGNC,18576,CCNO,isa,FPLX,000130,Cyclin +HGNC,1599,CCNT1,isa,FPLX,000130,Cyclin +HGNC,1600,CCNT2,isa,FPLX,000130,Cyclin +HGNC,23354,CCNY,isa,FPLX,000130,Cyclin +HGNC,26868,CCNYL1,isa,FPLX,000130,Cyclin +HGNC,33206,CCNYL3,isa,FPLX,000130,Cyclin +FPLX,000131,Cyclin_A,isa,FPLX,000130,Cyclin +FPLX,000132,Cyclin_D,isa,FPLX,000130,Cyclin +FPLX,000133,Cyclin_E,isa,FPLX,000130,Cyclin +HGNC,6871,MAPK1,isa,FPLX,000161,ERK +HGNC,6877,MAPK3,isa,FPLX,000161,ERK +FPLX,000161,ERK,isa,FPLX,000283,MAPK +FPLX,000178,F_actin,isa,FPLX,000009,Actin +HGNC,3688,FGFR1,isa,FPLX,000168,FGFR +HGNC,3689,FGFR2,isa,FPLX,000168,FGFR +HGNC,3690,FGFR3,isa,FPLX,000168,FGFR +HGNC,3691,FGFR4,isa,FPLX,000168,FGFR +HGNC,3693,FGFRL1,isa,FPLX,000168,FGFR +HGNC,4616,GSK3A,isa,FPLX,000194,GSK3 +HGNC,4617,GSK3B,isa,FPLX,000194,GSK3 +HGNC,4852,HDAC1,isa,FPLX,000221,HDAC_I +HGNC,4853,HDAC2,isa,FPLX,000221,HDAC_I +HGNC,4854,HDAC3,isa,FPLX,000221,HDAC_I +HGNC,13315,HDAC8,isa,FPLX,000221,HDAC_I +HGNC,14063,HDAC4,isa,FPLX,000222,HDAC_II +HGNC,14068,HDAC5,isa,FPLX,000222,HDAC_II +HGNC,14067,HDAC7,isa,FPLX,000222,HDAC_II +HGNC,14065,HDAC9,isa,FPLX,000222,HDAC_II +HGNC,14064,HDAC6,isa,FPLX,000222,HDAC_II +HGNC,18128,HDAC10,isa,FPLX,000222,HDAC_II +HGNC,14929,SIRT1,isa,FPLX,000223,HDAC_III +HGNC,10886,SIRT2,isa,FPLX,000223,HDAC_III +HGNC,14931,SIRT3,isa,FPLX,000223,HDAC_III +HGNC,14932,SIRT4,isa,FPLX,000223,HDAC_III +HGNC,14933,SIRT5,isa,FPLX,000223,HDAC_III +HGNC,14934,SIRT6,isa,FPLX,000223,HDAC_III +HGNC,14935,SIRT7,isa,FPLX,000223,HDAC_III +HGNC,19086,HDAC11,isa,FPLX,000224,HDAC_IV +FPLX,000221,HDAC_I,isa,FPLX,000220,HDAC +FPLX,000222,HDAC_II,isa,FPLX,000220,HDAC +FPLX,000223,HDAC_III,isa,FPLX,000220,HDAC +FPLX,000224,HDAC_IV,isa,FPLX,000220,HDAC +HGNC,4910,HIF1A,partof,FPLX,000230,HIF1 +HGNC,700,ARNT,partof,FPLX,000230,HIF1 +HGNC,4910,HIF1A,isa,FPLX,000231,HIF_alpha +HGNC,3374,EPAS1,isa,FPLX,000231,HIF_alpha +HGNC,15825,HIF3A,isa,FPLX,000231,HIF_alpha +HGNC,700,ARNT,isa,FPLX,000232,HIF_beta +HGNC,16876,ARNT2,isa,FPLX,000232,HIF_beta +HGNC,701,ARNTL,isa,FPLX,000232,HIF_beta +FPLX,000231,HIF_alpha,partof,FPLX,000229,HIF +FPLX,000232,HIF_beta,partof,FPLX,000229,HIF +FPLX,000242,HSP90A,isa,FPLX,000241,HSP90 +FPLX,000243,HSP90AA,isa,FPLX,000242,HSP90A +HGNC,5253,HSP90AA1,isa,FPLX,000243,HSP90AA +HGNC,5258,HSP90AB1,isa,FPLX,000242,HSP90A +HGNC,12028,HSP90B1,isa,FPLX,000241,HSP90 +HGNC,16264,TRAP1,isa,FPLX,000241,HSP90 +FPLX,000234,Histone_H1,isa,FPLX,000233,Histone +FPLX,000235,Histone_H2A,isa,FPLX,000233,Histone +FPLX,000236,Histone_H2B,isa,FPLX,000233,Histone +FPLX,000237,Histone_H3,isa,FPLX,000233,Histone +FPLX,000238,Histone_H4,isa,FPLX,000233,Histone +HGNC,4714,H1F0,isa,FPLX,000234,Histone_H1 +HGNC,18463,H1FOO,isa,FPLX,000234,Histone_H1 +HGNC,4722,H1FX,isa,FPLX,000234,Histone_H1 +HGNC,4715,HIST1H1A,isa,FPLX,000234,Histone_H1 +HGNC,4719,HIST1H1B,isa,FPLX,000234,Histone_H1 +HGNC,4716,HIST1H1C,isa,FPLX,000234,Histone_H1 +HGNC,4717,HIST1H1D,isa,FPLX,000234,Histone_H1 +HGNC,4718,HIST1H1E,isa,FPLX,000234,Histone_H1 +HGNC,4720,HIST1H1T,isa,FPLX,000234,Histone_H1 +HGNC,24893,H1FNT,isa,FPLX,000234,Histone_H1 +UP,P0C0S8,H2A1_HUMAN,isa,FPLX,000235,Histone_H2A +HGNC,22516,H2AFB1,isa,FPLX,000235,Histone_H2A +UP,P0C5Y9,H2AB1_HUMAN,isa,FPLX,000235,Histone_H2A +HGNC,14456,H2AFJ,isa,FPLX,000235,Histone_H2A +HGNC,20664,H2AFV,isa,FPLX,000235,Histone_H2A +HGNC,4739,H2AFX,isa,FPLX,000235,Histone_H2A +HGNC,4740,H2AFY,isa,FPLX,000235,Histone_H2A +HGNC,14453,H2AFY2,isa,FPLX,000235,Histone_H2A +HGNC,4741,H2AFZ,isa,FPLX,000235,Histone_H2A +HGNC,18729,HIST1H2AA,isa,FPLX,000235,Histone_H2A +HGNC,4733,HIST1H2AC,isa,FPLX,000235,Histone_H2A +HGNC,4729,HIST1H2AD,isa,FPLX,000235,Histone_H2A +HGNC,13671,HIST1H2AH,isa,FPLX,000235,Histone_H2A +HGNC,4727,HIST1H2AJ,isa,FPLX,000235,Histone_H2A +HGNC,20508,HIST2H2AB,isa,FPLX,000235,Histone_H2A +HGNC,4738,HIST2H2AC,isa,FPLX,000235,Histone_H2A +HGNC,20507,HIST3H2A,isa,FPLX,000235,Histone_H2A +UP,P04908,H2A1B_HUMAN,isa,FPLX,000235,Histone_H2A +UP,Q6FI13,H2A2A_HUMAN,isa,FPLX,000235,Histone_H2A +UP,P62807,H2B1C_HUMAN,isa,FPLX,000236,Histone_H2B +HGNC,18730,HIST1H2BA,isa,FPLX,000236,Histone_H2B +HGNC,4751,HIST1H2BB,isa,FPLX,000236,Histone_H2B +HGNC,4747,HIST1H2BD,isa,FPLX,000236,Histone_H2B +HGNC,4755,HIST1H2BH,isa,FPLX,000236,Histone_H2B +HGNC,4761,HIST1H2BJ,isa,FPLX,000236,Histone_H2B +HGNC,13954,HIST1H2BK,isa,FPLX,000236,Histone_H2B +HGNC,4748,HIST1H2BL,isa,FPLX,000236,Histone_H2B +HGNC,4750,HIST1H2BM,isa,FPLX,000236,Histone_H2B +HGNC,4749,HIST1H2BN,isa,FPLX,000236,Histone_H2B +HGNC,4758,HIST1H2BO,isa,FPLX,000236,Histone_H2B +HGNC,20516,HIST2H2BC,isa,FPLX,000236,Histone_H2B +HGNC,20517,HIST2H2BD,isa,FPLX,000236,Histone_H2B +HGNC,4760,HIST2H2BE,isa,FPLX,000236,Histone_H2B +HGNC,24700,HIST2H2BF,isa,FPLX,000236,Histone_H2B +HGNC,20514,HIST3H2BB,isa,FPLX,000236,Histone_H2B +HGNC,4762,H2BFS,isa,FPLX,000236,Histone_H2B +HGNC,27867,H2BFM,isa,FPLX,000236,Histone_H2B +HGNC,27252,H2BFWT,isa,FPLX,000236,Histone_H2B +UP,P68431,H31_HUMAN,isa,FPLX,000237,Histone_H3 +UP,Q71DI3,H32_HUMAN,isa,FPLX,000237,Histone_H3 +HGNC,4778,HIST3H3,isa,FPLX,000237,Histone_H3 +UP,P84243,H33_HUMAN,isa,FPLX,000237,Histone_H3 +HGNC,33164,H3F3C,isa,FPLX,000237,Histone_H3 +UP,P62805,H4_HUMAN,isa,FPLX,000238,Histone_H4 +HGNC,4792,HIST1H4G,isa,FPLX,000238,Histone_H4 +HGNC,11362,STAT1,isa,FPLX,000453,STAT +HGNC,11363,STAT2,isa,FPLX,000453,STAT +HGNC,11364,STAT3,isa,FPLX,000453,STAT +HGNC,11365,STAT4,isa,FPLX,000453,STAT +HGNC,11366,STAT5A,isa,FPLX,000454,STAT5 +HGNC,11367,STAT5B,isa,FPLX,000454,STAT5 +HGNC,11368,STAT6,isa,FPLX,000453,STAT +FPLX,000454,STAT5,isa,FPLX,000453,STAT +HGNC,8799,PDGFA,isa,FPLX,000342,PDGF +HGNC,8800,PDGFB,isa,FPLX,000342,PDGF +HGNC,8801,PDGFC,isa,FPLX,000342,PDGF +HGNC,30620,PDGFD,isa,FPLX,000342,PDGF +HGNC,8799,PDGFA,partof,FPLX,000347,PDGF_AA +HGNC,8799,PDGFA,partof,FPLX,000348,PDGF_AB +HGNC,8800,PDGFB,partof,FPLX,000348,PDGF_AB +HGNC,8800,PDGFB,partof,FPLX,000349,PDGF_BB +HGNC,8801,PDGFC,partof,FPLX,000350,PDGF_CC +HGNC,30620,PDGFD,partof,FPLX,000351,PDGF_DD +HGNC,8803,PDGFRA,isa,FPLX,000343,PDGFR +HGNC,8804,PDGFRB,isa,FPLX,000343,PDGFR +HGNC,8803,PDGFRA,partof,FPLX,000344,PDGFR_AA +HGNC,8803,PDGFRA,partof,FPLX,000345,PDGFR_AB +HGNC,8804,PDGFRB,partof,FPLX,000345,PDGFR_AB +HGNC,8804,PDGFRB,partof,FPLX,000346,PDGFR_BB +HGNC,4389,GNAO1,isa,FPLX,000213,G_i_alpha +HGNC,4384,GNAI1,isa,FPLX,000213,G_i_alpha +HGNC,4385,GNAI2,isa,FPLX,000213,G_i_alpha +HGNC,4387,GNAI3,isa,FPLX,000213,G_i_alpha +HGNC,4393,GNAT1,isa,FPLX,000213,G_i_alpha +HGNC,4394,GNAT2,isa,FPLX,000213,G_i_alpha +HGNC,22800,GNAT3,isa,FPLX,000213,G_i_alpha +HGNC,4395,GNAZ,isa,FPLX,000213,G_i_alpha +HGNC,4392,GNAS,isa,FPLX,000218,G_s_alpha +HGNC,4388,GNAL,isa,FPLX,000218,G_s_alpha +HGNC,4390,GNAQ,isa,FPLX,000216,G_q_alpha +HGNC,4379,GNA11,isa,FPLX,000216,G_q_alpha +HGNC,4382,GNA14,isa,FPLX,000216,G_q_alpha +HGNC,4383,GNA15,isa,FPLX,000216,G_q_alpha +HGNC,4380,GNA12,isa,FPLX,000208,G_12_alpha +HGNC,4381,GNA13,isa,FPLX,000208,G_12_alpha +FPLX,000213,G_i_alpha,isa,FPLX,000209,G_alpha +FPLX,000218,G_s_alpha,isa,FPLX,000209,G_alpha +FPLX,000216,G_q_alpha,isa,FPLX,000209,G_alpha +FPLX,000208,G_12_alpha,isa,FPLX,000209,G_alpha +FPLX,000213,G_i_alpha,partof,FPLX,000212,G_i +FPLX,000218,G_s_alpha,partof,FPLX,000217,G_s +FPLX,000216,G_q_alpha,partof,FPLX,000215,G_q +FPLX,000208,G_12_alpha,partof,FPLX,000207,G_12 +FPLX,000212,G_i,isa,FPLX,000214,G_protein +FPLX,000217,G_s,isa,FPLX,000214,G_protein +FPLX,000215,G_q,isa,FPLX,000214,G_protein +FPLX,000207,G_12,isa,FPLX,000214,G_protein +HGNC,19989,ANAPC2,partof,FPLX,000050,APC_C +HGNC,14452,ANAPC11,partof,FPLX,000050,APC_C +HGNC,19988,ANAPC1,partof,FPLX,000050,APC_C +HGNC,1720,CDC16,partof,FPLX,000050,APC_C +HGNC,1728,CDC27,partof,FPLX,000050,APC_C +HGNC,1724,CDC23,partof,FPLX,000050,APC_C +HGNC,15713,ANAPC5,partof,FPLX,000050,APC_C +HGNC,24077,ANAPC10,partof,FPLX,000050,APC_C +HGNC,24531,ANAPC15,partof,FPLX,000050,APC_C +HGNC,24540,ANAPC13,partof,FPLX,000050,APC_C +HGNC,17839,CDC26,partof,FPLX,000050,APC_C +HGNC,26976,ANAPC16,partof,FPLX,000050,APC_C +HGNC,17380,ANAPC7,partof,FPLX,000050,APC_C +HGNC,19990,ANAPC4,partof,FPLX,000050,APC_C +HGNC,3236,EGFR,isa,FPLX,000160,ERBB +HGNC,3430,ERBB2,isa,FPLX,000160,ERBB +HGNC,3431,ERBB3,isa,FPLX,000160,ERBB +HGNC,3432,ERBB4,isa,FPLX,000160,ERBB +HGNC,3296,EIF4G1,isa,FPLX,000155,EIF4G +HGNC,3297,EIF4G2,isa,FPLX,000155,EIF4G +HGNC,3298,EIF4G3,isa,FPLX,000155,EIF4G +HGNC,7775,NFATC1,isa,FPLX,000309,NFAT +HGNC,7776,NFATC2,isa,FPLX,000309,NFAT +HGNC,7777,NFATC3,isa,FPLX,000309,NFAT +HGNC,7778,NFATC4,isa,FPLX,000309,NFAT +HGNC,7774,NFAT5,isa,FPLX,000309,NFAT +HGNC,4706,GYS1,isa,FPLX,000206,GYS +HGNC,4707,GYS2,isa,FPLX,000206,GYS +HGNC,20766,TUBA1A,isa,FPLX,000483,TUBA +HGNC,18809,TUBA1B,isa,FPLX,000483,TUBA +HGNC,20768,TUBA1C,isa,FPLX,000483,TUBA +HGNC,12408,TUBA3C,isa,FPLX,000483,TUBA +HGNC,24071,TUBA3D,isa,FPLX,000483,TUBA +HGNC,20765,TUBA3E,isa,FPLX,000483,TUBA +HGNC,12407,TUBA4A,isa,FPLX,000483,TUBA +HGNC,12410,TUBA8,isa,FPLX,000483,TUBA +HGNC,23534,TUBAL3,isa,FPLX,000483,TUBA +HGNC,20778,TUBB,isa,FPLX,000484,TUBB +HGNC,16257,TUBB1,isa,FPLX,000484,TUBB +HGNC,12412,TUBB2A,isa,FPLX,000484,TUBB +HGNC,30829,TUBB2B,isa,FPLX,000484,TUBB +HGNC,20772,TUBB3,isa,FPLX,000484,TUBB +HGNC,20774,TUBB4A,isa,FPLX,000484,TUBB +HGNC,20771,TUBB4B,isa,FPLX,000484,TUBB +HGNC,20776,TUBB6,isa,FPLX,000484,TUBB +HGNC,12417,TUBG1,isa,FPLX,000485,TUBG +HGNC,12419,TUBG2,isa,FPLX,000485,TUBG +FPLX,000483,TUBA,isa,FPLX,000486,Tubulin +FPLX,000484,TUBB,isa,FPLX,000486,Tubulin +FPLX,000485,TUBG,isa,FPLX,000486,Tubulin +HGNC,16811,TUBD1,isa,FPLX,000486,Tubulin +HGNC,20775,TUBE1,isa,FPLX,000486,Tubulin +HGNC,6190,JAK1,isa,FPLX,000266,JAK +HGNC,6192,JAK2,isa,FPLX,000266,JAK +HGNC,6193,JAK3,isa,FPLX,000266,JAK +HGNC,12440,TYK2,isa,FPLX,000266,JAK +HGNC,1706,CD8A,isa,FPLX,000090,CD8 +HGNC,1707,CD8B,isa,FPLX,000090,CD8 +HGNC,6535,LDHA,isa,FPLX,000275,LDH +HGNC,6541,LDHB,isa,FPLX,000275,LDH +HGNC,6544,LDHC,isa,FPLX,000275,LDH +HGNC,10430,RPS6KA1,isa,FPLX,000329,P90RSK +HGNC,10431,RPS6KA2,isa,FPLX,000329,P90RSK +HGNC,10432,RPS6KA3,isa,FPLX,000329,P90RSK +HGNC,10433,RPS6KA4,isa,FPLX,000329,P90RSK +HGNC,10434,RPS6KA5,isa,FPLX,000329,P90RSK +HGNC,10435,RPS6KA6,isa,FPLX,000329,P90RSK +HGNC,10436,RPS6KB1,isa,FPLX,000328,P70S6K +HGNC,10437,RPS6KB2,isa,FPLX,000328,P70S6K +FPLX,000329,P90RSK,isa,FPLX,000422,RSK +FPLX,000328,P70S6K,isa,FPLX,000422,RSK +HGNC,9955,RELA,isa,FPLX,000313,NFkappaB_2 +HGNC,9956,RELB,isa,FPLX,000313,NFkappaB_2 +HGNC,9954,REL,isa,FPLX,000313,NFkappaB_2 +HGNC,7794,NFKB1,isa,FPLX,000312,NFkappaB_1 +HGNC,7795,NFKB2,isa,FPLX,000312,NFkappaB_1 +FPLX,000312,NFkappaB_1,partof,FPLX,000311,NFkappaB +FPLX,000313,NFkappaB_2,partof,FPLX,000311,NFkappaB +HGNC,11847,TLR1,isa,FPLX,000472,TLR 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+HGNC,160,ACTL6B,partof,FPLX,000457,SWI_SNF +HGNC,11099,HLTF,partof,FPLX,000457,SWI_SNF +HGNC,1067,BMP1,isa,FPLX,000067,BMP +HGNC,1069,BMP2,isa,FPLX,000067,BMP +HGNC,1070,BMP3,isa,FPLX,000067,BMP +HGNC,1071,BMP4,isa,FPLX,000067,BMP +HGNC,1072,BMP5,isa,FPLX,000067,BMP +HGNC,1073,BMP6,isa,FPLX,000067,BMP +HGNC,1074,BMP7,isa,FPLX,000067,BMP +HGNC,21650,BMP8A,isa,FPLX,000067,BMP +HGNC,1075,BMP8B,isa,FPLX,000067,BMP +HGNC,20869,BMP10,isa,FPLX,000067,BMP +HGNC,1068,BMP15,isa,FPLX,000067,BMP +HGNC,5969,IL12A,isa,FPLX,000253,IL12 +HGNC,5970,IL12B,isa,FPLX,000253,IL12 +HGNC,5991,IL1A,isa,FPLX,000252,IL1 +HGNC,5992,IL1B,isa,FPLX,000252,IL1 +HGNC,11179,SOD1,isa,FPLX,000447,SOD +HGNC,11180,SOD2,isa,FPLX,000447,SOD +HGNC,11181,SOD3,isa,FPLX,000447,SOD +HGNC,12362,TSC1,isa,FPLX,000482,TSC +HGNC,12363,TSC2,isa,FPLX,000482,TSC +HGNC,3819,FOXO1,isa,FPLX,000174,FOXO +HGNC,3821,FOXO3,isa,FPLX,000174,FOXO +HGNC,7139,FOXO4,isa,FPLX,000174,FOXO +HGNC,24814,FOXO6,isa,FPLX,000174,FOXO 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+HGNC,10252,ROCK2,isa,FPLX,000419,ROCK +HGNC,10840,SHC1,isa,FPLX,000432,SHC +HGNC,29869,SHC2,isa,FPLX,000432,SHC +HGNC,18181,SHC3,isa,FPLX,000432,SHC +HGNC,16743,SHC4,isa,FPLX,000432,SHC +HGNC,11187,SOS1,isa,FPLX,000448,SOS +HGNC,11188,SOS2,isa,FPLX,000448,SOS +HGNC,11269,SPRY1,isa,FPLX,000450,SPRY +HGNC,11270,SPRY2,isa,FPLX,000450,SPRY +HGNC,11271,SPRY3,isa,FPLX,000450,SPRY +HGNC,15533,SPRY4,isa,FPLX,000450,SPRY +HGNC,11749,TFDP1,isa,FPLX,000464,TFDP +HGNC,11751,TFDP2,isa,FPLX,000464,TFDP +HGNC,11805,TIAM1,isa,FPLX,000470,TIAM +HGNC,11806,TIAM2,isa,FPLX,000470,TIAM +HGNC,20249,SPRED1,isa,FPLX,000449,SPRED +HGNC,17722,SPRED2,isa,FPLX,000449,SPRED +HGNC,31041,SPRED3,isa,FPLX,000449,SPRED +HGNC,1885,CGA,partof,FPLX,000219,hCG +HGNC,1886,CGB3,partof,FPLX,000219,hCG +HGNC,10513,SAA1,isa,FPLX,000428,SAA +HGNC,10514,SAA2,isa,FPLX,000428,SAA +HGNC,10516,SAA4,isa,FPLX,000428,SAA +HGNC,6873,MAPK11,isa,FPLX,000326,p38 +HGNC,6874,MAPK12,isa,FPLX,000326,p38 +HGNC,6875,MAPK13,isa,FPLX,000326,p38 +HGNC,6876,MAPK14,isa,FPLX,000326,p38 +FPLX,000326,p38,isa,FPLX,000283,MAPK +HGNC,10773,SFN,isa,FPLX,000323,p14_3_3 +HGNC,12849,YWHAB,isa,FPLX,000323,p14_3_3 +HGNC,12851,YWHAE,isa,FPLX,000323,p14_3_3 +HGNC,12852,YWHAG,isa,FPLX,000323,p14_3_3 +HGNC,12853,YWHAH,isa,FPLX,000323,p14_3_3 +HGNC,12854,YWHAQ,isa,FPLX,000323,p14_3_3 +HGNC,12855,YWHAZ,isa,FPLX,000323,p14_3_3 +HGNC,59,ABCC8,isa,FPLX,000456,Sulfonylurea_receptor +HGNC,60,ABCC9,isa,FPLX,000456,Sulfonylurea_receptor +HGNC,87,ACAD8,isa,FPLX,000004,ACAD +HGNC,21497,ACAD9,isa,FPLX,000004,ACAD +HGNC,88,ACADL,isa,FPLX,000004,ACAD +HGNC,89,ACADM,isa,FPLX,000004,ACAD +HGNC,90,ACADS,isa,FPLX,000004,ACAD +HGNC,92,ACADVL,isa,FPLX,000004,ACAD +HGNC,21597,ACAD10,isa,FPLX,000004,ACAD +HGNC,30211,ACAD11,isa,FPLX,000004,ACAD +HGNC,91,ACADSB,isa,FPLX,000004,ACAD +HGNC,4189,GCDH,isa,FPLX,000004,ACAD +HGNC,6186,IVD,isa,FPLX,000004,ACAD +HGNC,10996,SLC27A2,isa,FPLX,000006,Acetyl_CoA_synthetase +HGNC,3569,ACSL1,isa,FPLX,000006,Acetyl_CoA_synthetase +HGNC,3570,ACSL3,isa,FPLX,000006,Acetyl_CoA_synthetase +HGNC,3571,ACSL4,isa,FPLX,000006,Acetyl_CoA_synthetase +HGNC,16526,ACSL5,isa,FPLX,000006,Acetyl_CoA_synthetase +HGNC,16496,ACSL6,isa,FPLX,000006,Acetyl_CoA_synthetase +HGNC,119,ACOX1,isa,FPLX,000007,ACOX +HGNC,120,ACOX2,isa,FPLX,000007,ACOX +HGNC,121,ACOX3,isa,FPLX,000007,ACOX +HGNC,25621,ACOXL,isa,FPLX,000007,ACOX +HGNC,3569,ACSL1,isa,FPLX,000008,ACSL +HGNC,3570,ACSL3,isa,FPLX,000008,ACSL +HGNC,3571,ACSL4,isa,FPLX,000008,ACSL +HGNC,16526,ACSL5,isa,FPLX,000008,ACSL +HGNC,16496,ACSL6,isa,FPLX,000008,ACSL +HGNC,163,ACTN1,isa,FPLX,000014,ACTN +HGNC,164,ACTN2,isa,FPLX,000014,ACTN +HGNC,165,ACTN3,isa,FPLX,000014,ACTN +HGNC,166,ACTN4,isa,FPLX,000014,ACTN +HGNC,232,ADCY1,isa,FPLX,000017,ADCY +HGNC,233,ADCY2,isa,FPLX,000017,ADCY +HGNC,234,ADCY3,isa,FPLX,000017,ADCY +HGNC,235,ADCY4,isa,FPLX,000017,ADCY +HGNC,236,ADCY5,isa,FPLX,000017,ADCY +HGNC,237,ADCY6,isa,FPLX,000017,ADCY +HGNC,238,ADCY7,isa,FPLX,000017,ADCY +HGNC,239,ADCY8,isa,FPLX,000017,ADCY +HGNC,240,ADCY9,isa,FPLX,000017,ADCY +HGNC,21285,ADCY10,isa,FPLX,000017,ADCY +HGNC,249,ADH1A,isa,FPLX,000018,ADH +HGNC,250,ADH1B,isa,FPLX,000018,ADH +HGNC,251,ADH1C,isa,FPLX,000018,ADH +HGNC,252,ADH4,isa,FPLX,000018,ADH +HGNC,253,ADH5,isa,FPLX,000018,ADH +HGNC,255,ADH6,isa,FPLX,000018,ADH +HGNC,256,ADH7,isa,FPLX,000018,ADH +HGNC,16354,ADHFE1,isa,FPLX,000018,ADH +HGNC,277,ADRA1A,isa,FPLX,000019,ADRA +HGNC,278,ADRA1B,isa,FPLX,000019,ADRA +HGNC,280,ADRA1D,isa,FPLX,000019,ADRA +HGNC,281,ADRA2A,isa,FPLX,000019,ADRA +HGNC,282,ADRA2B,isa,FPLX,000019,ADRA +HGNC,283,ADRA2C,isa,FPLX,000019,ADRA +HGNC,281,ADRA2A,isa,FPLX,000020,ADRA2 +HGNC,282,ADRA2B,isa,FPLX,000020,ADRA2 +HGNC,283,ADRA2C,isa,FPLX,000020,ADRA2 +HGNC,285,ADRB1,isa,FPLX,000021,ADRB +HGNC,286,ADRB2,isa,FPLX,000021,ADRB +HGNC,288,ADRB3,isa,FPLX,000021,ADRB +HGNC,289,GRK2,isa,FPLX,000022,ADRBK +HGNC,290,GRK3,isa,FPLX,000022,ADRBK +HGNC,402,ALDH1A1,isa,FPLX,000024,ALDH +HGNC,15472,ALDH1A2,isa,FPLX,000024,ALDH +HGNC,409,ALDH1A3,isa,FPLX,000024,ALDH +HGNC,404,ALDH2,isa,FPLX,000024,ALDH +HGNC,405,ALDH3A1,isa,FPLX,000024,ALDH +HGNC,403,ALDH3A2,isa,FPLX,000024,ALDH +HGNC,410,ALDH3B1,isa,FPLX,000024,ALDH +HGNC,408,ALDH5A1,isa,FPLX,000024,ALDH +HGNC,877,ALDH7A1,isa,FPLX,000024,ALDH +HGNC,412,ALDH9A1,isa,FPLX,000024,ALDH +HGNC,414,ALDOA,isa,FPLX,000025,ALDO +HGNC,417,ALDOB,isa,FPLX,000025,ALDO +HGNC,418,ALDOC,isa,FPLX,000025,ALDO +HGNC,600,APOA1,isa,FPLX,000051,APOA +HGNC,601,APOA2,isa,FPLX,000051,APOA +HGNC,602,APOA4,isa,FPLX,000051,APOA +HGNC,17288,APOA5,isa,FPLX,000051,APOA +FPLX,000051,APOA,isa,FPLX,000052,Apolipoprotein +HGNC,613,APOE,isa,FPLX,000052,Apolipoprotein +HGNC,711,ARRB1,isa,FPLX,000055,ARRB +HGNC,712,ARRB2,isa,FPLX,000055,ARRB +HGNC,16489,ATG4A,isa,FPLX,000056,ATG4 +HGNC,20790,ATG4B,isa,FPLX,000056,ATG4 +HGNC,16040,ATG4C,isa,FPLX,000056,ATG4 +HGNC,20789,ATG4D,isa,FPLX,000056,ATG4 +HGNC,903,AXIN1,isa,FPLX,000062,AXIN +HGNC,904,AXIN2,isa,FPLX,000062,AXIN +HGNC,590,BIRC2,isa,FPLX,000066,BIRC +HGNC,591,BIRC3,isa,FPLX,000066,BIRC +HGNC,593,BIRC5,isa,FPLX,000066,BIRC +HGNC,13516,BIRC6,isa,FPLX,000066,BIRC +HGNC,13702,BIRC7,isa,FPLX,000066,BIRC +HGNC,14878,BIRC8,isa,FPLX,000066,BIRC +HGNC,7634,NAIP,isa,FPLX,000066,BIRC +HGNC,592,XIAP,isa,FPLX,000066,BIRC +HGNC,4214,GDF1,isa,FPLX,000067,BMP +HGNC,4217,GDF2,isa,FPLX,000067,BMP +HGNC,4218,GDF3,isa,FPLX,000067,BMP +HGNC,4220,GDF5,isa,FPLX,000067,BMP +HGNC,4221,GDF6,isa,FPLX,000067,BMP +HGNC,4222,GDF7,isa,FPLX,000067,BMP +FPLX,000069,BMP_receptor_type_I,isa,FPLX,000068,BMP_receptor +FPLX,000070,BMP_receptor_type_II,isa,FPLX,000068,BMP_receptor +HGNC,171,ACVR1,isa,FPLX,000069,BMP_receptor_type_I +HGNC,1076,BMPR1A,isa,FPLX,000069,BMP_receptor_type_I +HGNC,1077,BMPR1B,isa,FPLX,000069,BMP_receptor_type_I +HGNC,173,ACVR2A,isa,FPLX,000070,BMP_receptor_type_II +HGNC,174,ACVR2B,isa,FPLX,000070,BMP_receptor_type_II +HGNC,1078,BMPR2,isa,FPLX,000070,BMP_receptor_type_II +HGNC,1442,CALM1,isa,FPLX,000075,CALM +HGNC,1445,CALM2,isa,FPLX,000075,CALM +HGNC,1449,CALM3,isa,FPLX,000075,CALM +HGNC,1459,CAMK1,isa,FPLX,000076,CAMK +HGNC,19341,CAMK1D,isa,FPLX,000076,CAMK +HGNC,14585,CAMK1G,isa,FPLX,000076,CAMK +HGNC,1460,CAMK2A,isa,FPLX,000078,CAMK2_family +HGNC,1461,CAMK2B,isa,FPLX,000078,CAMK2_family +HGNC,1462,CAMK2D,isa,FPLX,000078,CAMK2_family +HGNC,1463,CAMK2G,isa,FPLX,000078,CAMK2_family +HGNC,1464,CAMK4,isa,FPLX,000076,CAMK +FPLX,000078,CAMK2_family,isa,FPLX,000076,CAMK +HGNC,1476,CAPN1,isa,FPLX,000079,CAPN +HGNC,1477,CAPN10,isa,FPLX,000079,CAPN +HGNC,1478,CAPN11,isa,FPLX,000079,CAPN +HGNC,13249,CAPN12,isa,FPLX,000079,CAPN +HGNC,16663,CAPN13,isa,FPLX,000079,CAPN +HGNC,16664,CAPN14,isa,FPLX,000079,CAPN +HGNC,1479,CAPN2,isa,FPLX,000079,CAPN +HGNC,1480,CAPN3,isa,FPLX,000079,CAPN +HGNC,1482,CAPN5,isa,FPLX,000079,CAPN +HGNC,1483,CAPN6,isa,FPLX,000079,CAPN +HGNC,1484,CAPN7,isa,FPLX,000079,CAPN +HGNC,1486,CAPN9,isa,FPLX,000079,CAPN +HGNC,11182,CAPN15,isa,FPLX,000079,CAPN +HGNC,1485,CAPN8,isa,FPLX,000079,CAPN +HGNC,1863,CES1,isa,FPLX,000080,Carboxylesterase +HGNC,1864,CES2,isa,FPLX,000080,Carboxylesterase +HGNC,1865,CES3,isa,FPLX,000080,Carboxylesterase +HGNC,26741,CES4A,isa,FPLX,000080,Carboxylesterase +HGNC,26459,CES5A,isa,FPLX,000080,Carboxylesterase +HGNC,1527,CAV1,isa,FPLX,000083,CAV +HGNC,1528,CAV2,isa,FPLX,000083,CAV +HGNC,1529,CAV3,isa,FPLX,000083,CAV +HGNC,3619,FCGR3A,isa,FPLX,000086,CD16 +HGNC,3620,FCGR3B,isa,FPLX,000086,CD16 +HGNC,3616,FCGR2A,isa,FPLX,000088,CD32 +HGNC,3618,FCGR2B,isa,FPLX,000088,CD32 +HGNC,15626,FCGR2C,isa,FPLX,000088,CD32 +HGNC,3613,FCGR1A,isa,FPLX,000089,CD64 +HGNC,3614,FCGR1B,isa,FPLX,000089,CD64 +HGNC,1725,CDC25A,isa,FPLX,000091,CDC25 +HGNC,1726,CDC25B,isa,FPLX,000091,CDC25 +HGNC,1727,CDC25C,isa,FPLX,000091,CDC25 +HGNC,1748,CDH1,isa,FPLX,000074,Cadherin +HGNC,1749,CDH10,isa,FPLX,000074,Cadherin +HGNC,1750,CDH11,isa,FPLX,000074,Cadherin +HGNC,1751,CDH12,isa,FPLX,000074,Cadherin +HGNC,1753,CDH13,isa,FPLX,000074,Cadherin +HGNC,1754,CDH15,isa,FPLX,000074,Cadherin +HGNC,1755,CDH16,isa,FPLX,000074,Cadherin +HGNC,1756,CDH17,isa,FPLX,000074,Cadherin +HGNC,1757,CDH18,isa,FPLX,000074,Cadherin +HGNC,1758,CDH19,isa,FPLX,000074,Cadherin +HGNC,1759,CDH2,isa,FPLX,000074,Cadherin +HGNC,1760,CDH20,isa,FPLX,000074,Cadherin +HGNC,13251,CDH22,isa,FPLX,000074,Cadherin +HGNC,14265,CDH24,isa,FPLX,000074,Cadherin +HGNC,1762,CDH3,isa,FPLX,000074,Cadherin +HGNC,1763,CDH4,isa,FPLX,000074,Cadherin +HGNC,1764,CDH5,isa,FPLX,000074,Cadherin +HGNC,1765,CDH6,isa,FPLX,000074,Cadherin +HGNC,1766,CDH7,isa,FPLX,000074,Cadherin +HGNC,1767,CDH8,isa,FPLX,000074,Cadherin +HGNC,1768,CDH9,isa,FPLX,000074,Cadherin +HGNC,1833,CEBPA,isa,FPLX,000097,CEBP +HGNC,1834,CEBPB,isa,FPLX,000097,CEBP +HGNC,1835,CEBPD,isa,FPLX,000097,CEBP +HGNC,1837,CEBPG,isa,FPLX,000097,CEBP +HGNC,1836,CEBPE,isa,FPLX,000097,CEBP +HGNC,1565,ACKR2,isa,FPLX,000100,Chemokine_receptor +HGNC,1602,CCR1,isa,FPLX,000100,Chemokine_receptor +HGNC,4474,CCR10,isa,FPLX,000100,Chemokine_receptor +HGNC,1603,CCR2,isa,FPLX,000100,Chemokine_receptor +HGNC,1604,CCR3,isa,FPLX,000100,Chemokine_receptor +HGNC,1605,CCR4,isa,FPLX,000100,Chemokine_receptor +HGNC,1606,CCR5,isa,FPLX,000100,Chemokine_receptor +HGNC,1607,CCR6,isa,FPLX,000100,Chemokine_receptor +HGNC,1608,CCR7,isa,FPLX,000100,Chemokine_receptor +HGNC,1609,CCR8,isa,FPLX,000100,Chemokine_receptor +HGNC,1610,CCR9,isa,FPLX,000100,Chemokine_receptor +HGNC,1611,ACKR4,isa,FPLX,000100,Chemokine_receptor +HGNC,1612,CCRL2,isa,FPLX,000100,Chemokine_receptor +HGNC,2558,CX3CR1,isa,FPLX,000100,Chemokine_receptor +HGNC,6026,CXCR1,isa,FPLX,000100,Chemokine_receptor +HGNC,6027,CXCR2,isa,FPLX,000100,Chemokine_receptor +HGNC,4540,CXCR3,isa,FPLX,000100,Chemokine_receptor +HGNC,2561,CXCR4,isa,FPLX,000100,Chemokine_receptor +HGNC,1060,CXCR5,isa,FPLX,000100,Chemokine_receptor +HGNC,16647,CXCR6,isa,FPLX,000100,Chemokine_receptor +HGNC,23692,ACKR3,isa,FPLX,000100,Chemokine_receptor +HGNC,1625,XCR1,isa,FPLX,000100,Chemokine_receptor +HGNC,108,ACHE,isa,FPLX,000101,Cholinesterase +HGNC,983,BCHE,isa,FPLX,000101,Cholinesterase +HGNC,1950,CHRM1,isa,FPLX,000102,CHRM +HGNC,1951,CHRM2,isa,FPLX,000102,CHRM +HGNC,1952,CHRM3,isa,FPLX,000102,CHRM +HGNC,1953,CHRM4,isa,FPLX,000102,CHRM +HGNC,1954,CHRM5,isa,FPLX,000102,CHRM +HGNC,2197,COL1A1,isa,FPLX,000109,COL1 +HGNC,2198,COL1A2,isa,FPLX,000109,COL1 +HGNC,2202,COL4A1,isa,FPLX,000110,COL4 +HGNC,2203,COL4A2,isa,FPLX,000110,COL4 +HGNC,2204,COL4A3,isa,FPLX,000110,COL4 +HGNC,2206,COL4A4,isa,FPLX,000110,COL4 +HGNC,2207,COL4A5,isa,FPLX,000110,COL4 +HGNC,2208,COL4A6,isa,FPLX,000110,COL4 +HGNC,2209,COL5A1,isa,FPLX,000111,COL5 +HGNC,2210,COL5A2,isa,FPLX,000111,COL5 +HGNC,14864,COL5A3,isa,FPLX,000111,COL5 +HGNC,2265,COX4I1,isa,FPLX,000114,COX4 +HGNC,16232,COX4I2,isa,FPLX,000114,COX4 +HGNC,2277,COX6A1,isa,FPLX,000115,COX6A +HGNC,2279,COX6A2,isa,FPLX,000115,COX6A +HGNC,2280,COX6B1,isa,FPLX,000116,COX6B +HGNC,24380,COX6B2,isa,FPLX,000116,COX6B +HGNC,2287,COX7A1,isa,FPLX,000117,COX7A +HGNC,2288,COX7A2,isa,FPLX,000117,COX7A +HGNC,2291,COX7B,isa,FPLX,000118,COX7B +HGNC,24381,COX7B2,isa,FPLX,000118,COX7B +HGNC,2294,COX8A,isa,FPLX,000119,COX8 +HGNC,24382,COX8C,isa,FPLX,000119,COX8 +HGNC,2267,COX5A,partof,FPLX,000113,COX +HGNC,2269,COX5B,partof,FPLX,000113,COX +FPLX,000114,COX4,partof,FPLX,000113,COX +FPLX,000115,COX6A,partof,FPLX,000113,COX +FPLX,000116,COX6B,partof,FPLX,000113,COX +FPLX,000117,COX7A,partof,FPLX,000113,COX +FPLX,000118,COX7B,partof,FPLX,000113,COX +FPLX,000119,COX8,partof,FPLX,000113,COX +HGNC,2260,COX10,partof,FPLX,000113,COX +HGNC,2261,COX11,partof,FPLX,000113,COX +HGNC,2263,COX15,partof,FPLX,000113,COX +HGNC,2264,COX17,partof,FPLX,000113,COX +HGNC,304,CRISP1,isa,FPLX,000121,CRISP +HGNC,12024,CRISP2,isa,FPLX,000121,CRISP +HGNC,16904,CRISP3,isa,FPLX,000121,CRISP +HGNC,2509,CTNNA1,isa,FPLX,000126,CTNNA +HGNC,2510,CTNNA2,isa,FPLX,000126,CTNNA 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+HGNC,23366,ARPC5L,partof,FPLX,000054,Arp2_3_protein +HGNC,986,BCKDHA,partof,FPLX,000064,BCKDC +HGNC,987,BCKDHB,partof,FPLX,000064,BCKDC +HGNC,2698,DBT,partof,FPLX,000064,BCKDC +HGNC,2898,DLD,partof,FPLX,000064,BCKDC +HGNC,1241,C1QA,partof,FPLX,000072,C1 +HGNC,1242,C1QB,partof,FPLX,000072,C1 +HGNC,1245,C1QC,partof,FPLX,000072,C1 +HGNC,1246,C1R,partof,FPLX,000072,C1 +HGNC,1247,C1S,partof,FPLX,000072,C1 +HGNC,1241,C1QA,partof,FPLX,000073,C1q +HGNC,1242,C1QB,partof,FPLX,000073,C1q +HGNC,1460,CAMK2A,partof,FPLX,000077,CAMK2_complex +HGNC,1461,CAMK2B,partof,FPLX,000077,CAMK2_complex +HGNC,1462,CAMK2D,partof,FPLX,000077,CAMK2_complex +HGNC,1463,CAMK2G,partof,FPLX,000077,CAMK2_complex +HGNC,10899,SKP1,partof,FPLX,000084,CBF3 +HGNC,1615,CCT2,partof,FPLX,000085,CCT_complex +HGNC,1616,CCT3,partof,FPLX,000085,CCT_complex +HGNC,1617,CCT4,partof,FPLX,000085,CCT_complex +HGNC,1618,CCT5,partof,FPLX,000085,CCT_complex +HGNC,1620,CCT6A,partof,FPLX,000085,CCT_complex +HGNC,1621,CCT6B,partof,FPLX,000085,CCT_complex +HGNC,1622,CCT7,partof,FPLX,000085,CCT_complex +HGNC,1623,CCT8,partof,FPLX,000085,CCT_complex +HGNC,11655,TCP1,partof,FPLX,000085,CCT_complex +HGNC,1677,CD247,partof,FPLX,000087,CD3 +HGNC,1673,CD3D,partof,FPLX,000087,CD3 +HGNC,1674,CD3E,partof,FPLX,000087,CD3 +HGNC,1675,CD3G,partof,FPLX,000087,CD3 +HGNC,1956,CHRNA2,partof,FPLX,000103,CHRN +HGNC,1957,CHRNA3,partof,FPLX,000103,CHRN +HGNC,1958,CHRNA4,partof,FPLX,000103,CHRN +HGNC,1959,CHRNA5,partof,FPLX,000103,CHRN +HGNC,15963,CHRNA6,partof,FPLX,000103,CHRN +HGNC,1960,CHRNA7,partof,FPLX,000103,CHRN +HGNC,1962,CHRNB2,partof,FPLX,000103,CHRN +HGNC,1963,CHRNB3,partof,FPLX,000103,CHRN +HGNC,1964,CHRNB4,partof,FPLX,000103,CHRN +HGNC,2090,CLTA,partof,FPLX,000105,Clathrin +HGNC,2091,CLTB,partof,FPLX,000105,Clathrin +HGNC,2092,CLTC,partof,FPLX,000105,Clathrin +HGNC,9811,RAD21,partof,FPLX,000108,Cohesin +HGNC,2468,SMC3,partof,FPLX,000108,Cohesin +HGNC,9234,MED1,partof,FPLX,000122,CRSP +HGNC,2370,MED14,partof,FPLX,000122,CRSP +HGNC,2375,MED17,partof,FPLX,000122,CRSP +HGNC,2372,MED23,partof,FPLX,000122,CRSP +HGNC,2376,MED26,partof,FPLX,000122,CRSP +HGNC,2377,MED27,partof,FPLX,000122,CRSP +HGNC,2378,MED7,partof,FPLX,000122,CRSP +HGNC,2961,DYNC1H1,partof,FPLX,000135,Cytoplasmic_dynein +HGNC,2963,DYNC1I1,partof,FPLX,000135,Cytoplasmic_dynein +HGNC,2964,DYNC1I2,partof,FPLX,000135,Cytoplasmic_dynein +HGNC,18745,DYNC1LI1,partof,FPLX,000135,Cytoplasmic_dynein +HGNC,2966,DYNC1LI2,partof,FPLX,000135,Cytoplasmic_dynein +HGNC,15476,DYNLL1,partof,FPLX,000135,Cytoplasmic_dynein +HGNC,15468,DYNLRB1,partof,FPLX,000135,Cytoplasmic_dynein +HGNC,15467,DYNLRB2,partof,FPLX,000135,Cytoplasmic_dynein +HGNC,9175,POLD1,partof,FPLX,000141,DNA_polymerase_delta +HGNC,9176,POLD2,partof,FPLX,000141,DNA_polymerase_delta +HGNC,20932,POLD3,partof,FPLX,000141,DNA_polymerase_delta +HGNC,14106,POLD4,partof,FPLX,000141,DNA_polymerase_delta +HGNC,2666,DAG1,partof,FPLX,000139,DGC +HGNC,2928,DMD,partof,FPLX,000139,DGC +HGNC,3057,DTNA,partof,FPLX,000139,DGC +HGNC,3058,DTNB,partof,FPLX,000139,DGC +HGNC,7872,NOS1,partof,FPLX,000139,DGC +HGNC,10805,SGCA,partof,FPLX,000139,DGC +HGNC,10806,SGCB,partof,FPLX,000139,DGC +HGNC,10807,SGCD,partof,FPLX,000139,DGC +HGNC,10808,SGCE,partof,FPLX,000139,DGC +HGNC,14075,SGCZ,partof,FPLX,000139,DGC +HGNC,11167,SNTA1,partof,FPLX,000139,DGC +HGNC,11168,SNTB1,partof,FPLX,000139,DGC +HGNC,13740,SNTG1,partof,FPLX,000139,DGC +HGNC,13741,SNTG2,partof,FPLX,000139,DGC +HGNC,11322,SSPN,partof,FPLX,000139,DGC +HGNC,12635,UTRN,partof,FPLX,000139,DGC +HGNC,3257,EIF2B1,partof,FPLX,000152,EIF2B +HGNC,3258,EIF2B2,partof,FPLX,000152,EIF2B +HGNC,3259,EIF2B3,partof,FPLX,000152,EIF2B +HGNC,3260,EIF2B4,partof,FPLX,000152,EIF2B +HGNC,3261,EIF2B5,partof,FPLX,000152,EIF2B +HGNC,3661,FGA,partof,FPLX,000169,Fibrinogen +HGNC,3662,FGB,partof,FPLX,000169,Fibrinogen +HGNC,3694,FGG,partof,FPLX,000169,Fibrinogen +HGNC,1885,CGA,partof,FPLX,000175,FSH +HGNC,3964,FSHB,partof,FPLX,000175,FSH +HGNC,29509,APH1A,partof,FPLX,000181,Gamma_secretase +HGNC,9508,PSEN1,partof,FPLX,000181,Gamma_secretase +HGNC,30100,PSENEN,partof,FPLX,000181,Gamma_secretase +HGNC,4446,GPAA1,partof,FPLX,000189,GPIT +HGNC,8965,PIGK,partof,FPLX,000189,GPIT +HGNC,14937,PIGS,partof,FPLX,000189,GPIT +HGNC,14938,PIGT,partof,FPLX,000189,GPIT +HGNC,15791,PIGU,partof,FPLX,000189,GPIT +HGNC,4650,GTF2E1,partof,FPLX,000196,GTF2E +HGNC,4651,GTF2E2,partof,FPLX,000196,GTF2E +HGNC,4652,GTF2F1,partof,FPLX,000197,GTF2F +HGNC,4653,GTF2F2,partof,FPLX,000197,GTF2F +HGNC,399,ALB,partof,FPLX,000225,HDL +HGNC,600,APOA1,partof,FPLX,000225,HDL +HGNC,601,APOA2,partof,FPLX,000225,HDL +HGNC,613,APOE,partof,FPLX,000225,HDL +HGNC,2095,CLU,partof,FPLX,000225,HDL +HGNC,4823,HBA1,partof,FPLX,000227,Hemoglobin +HGNC,4824,HBA2,partof,FPLX,000227,Hemoglobin +HGNC,4827,HBB,partof,FPLX,000227,Hemoglobin +HGNC,4829,HBD,partof,FPLX,000227,Hemoglobin +HGNC,4830,HBE1,partof,FPLX,000227,Hemoglobin +HGNC,4831,HBG1,partof,FPLX,000227,Hemoglobin +HGNC,4832,HBG2,partof,FPLX,000227,Hemoglobin +HGNC,4826,HBM,partof,FPLX,000227,Hemoglobin +HGNC,4833,HBQ1,partof,FPLX,000227,Hemoglobin +HGNC,4835,HBZ,partof,FPLX,000227,Hemoglobin +HGNC,4439,GP1BA,partof,FPLX,000188,GPIb_IX_V +HGNC,4440,GP1BB,partof,FPLX,000188,GPIb_IX_V +HGNC,4443,GP5,partof,FPLX,000188,GPIb_IX_V +HGNC,4444,GP9,partof,FPLX,000188,GPIb_IX_V +HGNC,1974,CHUK,partof,FPLX,000250,IKK_complex +HGNC,5960,IKBKB,partof,FPLX,000250,IKK_complex +HGNC,5961,IKBKG,partof,FPLX,000250,IKK_complex +HGNC,5439,IFNGR1,partof,FPLX,000263,Interferon_gamma_receptor +HGNC,5440,IFNGR2,partof,FPLX,000263,Interferon_gamma_receptor +HGNC,1148,BUB1,partof,FPLX,000270,Kinetochore +HGNC,1149,BUB1B,partof,FPLX,000270,Kinetochore +HGNC,1151,BUB3,partof,FPLX,000270,Kinetochore +HGNC,1854,CENPC,partof,FPLX,000270,Kinetochore +HGNC,1856,CENPE,partof,FPLX,000270,Kinetochore +HGNC,1857,CENPF,partof,FPLX,000270,Kinetochore +HGNC,17268,CENPH,partof,FPLX,000270,Kinetochore +HGNC,2712,DCTN2,partof,FPLX,000270,Kinetochore +HGNC,6391,KIF22,partof,FPLX,000270,Kinetochore +HGNC,6763,MAD2L1,partof,FPLX,000270,Kinetochore +HGNC,8574,PAFAH1B1,partof,FPLX,000270,Kinetochore +HGNC,9508,PSEN1,partof,FPLX,000270,Kinetochore +HGNC,9509,PSEN2,partof,FPLX,000270,Kinetochore +HGNC,11111,SMC1A,partof,FPLX,000270,Kinetochore +HGNC,16987,SUGT1,partof,FPLX,000270,Kinetochore +HGNC,11124,SUMO3,partof,FPLX,000270,Kinetochore +HGNC,13194,ZW10,partof,FPLX,000270,Kinetochore +HGNC,6481,LAMA1,partof,FPLX,000273,Laminin_111 +HGNC,6486,LAMB1,partof,FPLX,000273,Laminin_111 +HGNC,6492,LAMC1,partof,FPLX,000273,Laminin_111 +HGNC,6483,LAMA3,partof,FPLX,000274,Laminin_332 +HGNC,6490,LAMB3,partof,FPLX,000274,Laminin_332 +HGNC,6493,LAMC2,partof,FPLX,000274,Laminin_332 +HGNC,1885,CGA,partof,FPLX,000276,LH +HGNC,6584,LHB,partof,FPLX,000276,LH +HGNC,1331,C5,partof,FPLX,000278,MAC +HGNC,1339,C6,partof,FPLX,000278,MAC +HGNC,1346,C7,partof,FPLX,000278,MAC +HGNC,1352,C8A,partof,FPLX,000278,MAC +HGNC,1353,C8B,partof,FPLX,000278,MAC +HGNC,1354,C8G,partof,FPLX,000278,MAC +HGNC,1358,C9,partof,FPLX,000278,MAC +HGNC,799,ATP1A1,isa,FPLX,000057,ATP1A +HGNC,800,ATP1A2,isa,FPLX,000057,ATP1A +HGNC,801,ATP1A3,isa,FPLX,000057,ATP1A +HGNC,14073,ATP1A4,isa,FPLX,000057,ATP1A +HGNC,804,ATP1B1,isa,FPLX,000058,ATP1B +HGNC,805,ATP1B2,isa,FPLX,000058,ATP1B +HGNC,806,ATP1B3,isa,FPLX,000058,ATP1B +HGNC,808,ATP1B4,isa,FPLX,000058,ATP1B +FPLX,000057,ATP1A,partof,FPLX,000303,Na_K_ATPase +FPLX,000058,ATP1B,partof,FPLX,000303,Na_K_ATPase +HGNC,7455,MT-ND1,partof,FPLX,000301,NADH_dehydrogenase +HGNC,7456,MT-ND2,partof,FPLX,000301,NADH_dehydrogenase +HGNC,7458,MT-ND3,partof,FPLX,000301,NADH_dehydrogenase +HGNC,7459,MT-ND4,partof,FPLX,000301,NADH_dehydrogenase +HGNC,7460,MT-ND4L,partof,FPLX,000301,NADH_dehydrogenase +HGNC,7461,MT-ND5,partof,FPLX,000301,NADH_dehydrogenase +HGNC,7462,MT-ND6,partof,FPLX,000301,NADH_dehydrogenase +HGNC,2577,CYBA,partof,FPLX,000302,NADPH_oxidase +HGNC,2578,CYBB,partof,FPLX,000302,NADPH_oxidase +HGNC,3062,DUOX1,partof,FPLX,000302,NADPH_oxidase +HGNC,13273,DUOX2,partof,FPLX,000302,NADPH_oxidase +HGNC,7660,NCF1,partof,FPLX,000302,NADPH_oxidase +HGNC,7661,NCF2,partof,FPLX,000302,NADPH_oxidase +HGNC,7662,NCF4,partof,FPLX,000302,NADPH_oxidase +HGNC,7889,NOX1,partof,FPLX,000302,NADPH_oxidase +HGNC,7890,NOX3,partof,FPLX,000302,NADPH_oxidase +HGNC,7891,NOX4,partof,FPLX,000302,NADPH_oxidase +HGNC,14874,NOX5,partof,FPLX,000302,NADPH_oxidase +HGNC,9801,RAC1,partof,FPLX,000302,NADPH_oxidase +HGNC,7804,NFYA,partof,FPLX,000314,NFY +HGNC,7805,NFYB,partof,FPLX,000314,NFY +HGNC,7806,NFYC,partof,FPLX,000314,NFY +HGNC,1442,CALM1,partof,FPLX,000356,PhK +HGNC,8925,PHKA1,partof,FPLX,000356,PhK +HGNC,8926,PHKA2,partof,FPLX,000356,PhK +HGNC,8927,PHKB,partof,FPLX,000356,PhK +HGNC,8930,PHKG1,partof,FPLX,000356,PhK +HGNC,8931,PHKG2,partof,FPLX,000356,PhK +HGNC,1066,BMI1,partof,FPLX,000386,PRC1_complex +HGNC,1552,CBX2,partof,FPLX,000386,PRC1_complex +HGNC,1554,CBX4,partof,FPLX,000386,PRC1_complex +HGNC,15962,CBX8,partof,FPLX,000386,PRC1_complex +HGNC,12929,PCGF2,partof,FPLX,000386,PRC1_complex +HGNC,3182,PHC1,partof,FPLX,000386,PRC1_complex +HGNC,3183,PHC2,partof,FPLX,000386,PRC1_complex +HGNC,15682,PHC3,partof,FPLX,000386,PRC1_complex +HGNC,8919,PHF1,partof,FPLX,000386,PRC1_complex +HGNC,10018,RING1,partof,FPLX,000386,PRC1_complex +HGNC,10061,RNF2,partof,FPLX,000386,PRC1_complex +HGNC,19003,SCMH1,partof,FPLX,000386,PRC1_complex +HGNC,12856,YY1,partof,FPLX,000386,PRC1_complex +HGNC,12918,ZNF134,partof,FPLX,000386,PRC1_complex +HGNC,3188,EED,partof,FPLX,000387,PRC2_complex +HGNC,3526,EZH1,partof,FPLX,000387,PRC2_complex +HGNC,3527,EZH2,partof,FPLX,000387,PRC2_complex +HGNC,17101,SUZ12,partof,FPLX,000387,PRC2_complex +HGNC,8653,PCCA,partof,FPLX,000392,Propionyl_CoA_carboxylase +HGNC,8654,PCCB,partof,FPLX,000392,Propionyl_CoA_carboxylase +HGNC,9530,PSMA1,partof,FPLX,000394,Proteasome +HGNC,9531,PSMA2,partof,FPLX,000394,Proteasome +HGNC,9532,PSMA3,partof,FPLX,000394,Proteasome +HGNC,9533,PSMA4,partof,FPLX,000394,Proteasome +HGNC,9534,PSMA5,partof,FPLX,000394,Proteasome +HGNC,9535,PSMA6,partof,FPLX,000394,Proteasome +HGNC,9536,PSMA7,partof,FPLX,000394,Proteasome +HGNC,22985,PSMA8,partof,FPLX,000394,Proteasome +HGNC,9537,PSMB1,partof,FPLX,000394,Proteasome +HGNC,9538,PSMB10,partof,FPLX,000394,Proteasome +HGNC,9539,PSMB2,partof,FPLX,000394,Proteasome +HGNC,9540,PSMB3,partof,FPLX,000394,Proteasome +HGNC,9541,PSMB4,partof,FPLX,000394,Proteasome +HGNC,9542,PSMB5,partof,FPLX,000394,Proteasome +HGNC,9543,PSMB6,partof,FPLX,000394,Proteasome +HGNC,9544,PSMB7,partof,FPLX,000394,Proteasome +HGNC,9545,PSMB8,partof,FPLX,000394,Proteasome +HGNC,9546,PSMB9,partof,FPLX,000394,Proteasome +HGNC,9547,PSMC1,partof,FPLX,000394,Proteasome +HGNC,9548,PSMC2,partof,FPLX,000394,Proteasome +HGNC,9549,PSMC3,partof,FPLX,000394,Proteasome +HGNC,9551,PSMC4,partof,FPLX,000394,Proteasome +HGNC,9552,PSMC5,partof,FPLX,000394,Proteasome +HGNC,9553,PSMC6,partof,FPLX,000394,Proteasome +HGNC,9554,PSMD1,partof,FPLX,000394,Proteasome +HGNC,9555,PSMD10,partof,FPLX,000394,Proteasome +HGNC,9556,PSMD11,partof,FPLX,000394,Proteasome +HGNC,9557,PSMD12,partof,FPLX,000394,Proteasome +HGNC,9558,PSMD13,partof,FPLX,000394,Proteasome +HGNC,16889,PSMD14,partof,FPLX,000394,Proteasome +HGNC,9559,PSMD2,partof,FPLX,000394,Proteasome +HGNC,9560,PSMD3,partof,FPLX,000394,Proteasome +HGNC,9561,PSMD4,partof,FPLX,000394,Proteasome +HGNC,9563,PSMD5,partof,FPLX,000394,Proteasome +HGNC,9564,PSMD6,partof,FPLX,000394,Proteasome +HGNC,9565,PSMD7,partof,FPLX,000394,Proteasome +HGNC,9566,PSMD8,partof,FPLX,000394,Proteasome +HGNC,9567,PSMD9,partof,FPLX,000394,Proteasome +HGNC,9568,PSME1,partof,FPLX,000394,Proteasome +HGNC,9569,PSME2,partof,FPLX,000394,Proteasome +HGNC,9570,PSME3,partof,FPLX,000394,Proteasome +HGNC,9571,PSMF1,partof,FPLX,000394,Proteasome +HGNC,10845,SEM1,partof,FPLX,000394,Proteasome +HGNC,12628,USP5,partof,FPLX,000394,Proteasome +HGNC,2896,DLAT,partof,FPLX,000352,PDH +HGNC,2898,DLD,partof,FPLX,000352,PDH +HGNC,8806,PDHA1,partof,FPLX,000352,PDH +HGNC,8807,PDHA2,partof,FPLX,000352,PDH +HGNC,8808,PDHB,partof,FPLX,000352,PDH +HGNC,21350,PDHX,partof,FPLX,000352,PDH +HGNC,9969,RFC1,partof,FPLX,000411,RFC +HGNC,9970,RFC2,partof,FPLX,000411,RFC +HGNC,9971,RFC3,partof,FPLX,000411,RFC +HGNC,9972,RFC4,partof,FPLX,000411,RFC +HGNC,9973,RFC5,partof,FPLX,000411,RFC +HGNC,17264,POLR1A,partof,FPLX,000416,RNApo_I +HGNC,20454,POLR1B,partof,FPLX,000416,RNApo_I +HGNC,20194,POLR1C,partof,FPLX,000416,RNApo_I +HGNC,20422,POLR1D,partof,FPLX,000416,RNApo_I +HGNC,9187,POLR2A,partof,FPLX,000417,RNApo_II +HGNC,9188,POLR2B,partof,FPLX,000417,RNApo_II +HGNC,9189,POLR2C,partof,FPLX,000417,RNApo_II +HGNC,9191,POLR2D,partof,FPLX,000417,RNApo_II +HGNC,9192,POLR2E,partof,FPLX,000417,RNApo_II +HGNC,9193,POLR2F,partof,FPLX,000417,RNApo_II +HGNC,9194,POLR2G,partof,FPLX,000417,RNApo_II +HGNC,9195,POLR2H,partof,FPLX,000417,RNApo_II +HGNC,9196,POLR2I,partof,FPLX,000417,RNApo_II +HGNC,9197,POLR2J,partof,FPLX,000417,RNApo_II +HGNC,23208,POLR2J2,partof,FPLX,000417,RNApo_II +HGNC,9198,POLR2K,partof,FPLX,000417,RNApo_II +HGNC,9199,POLR2L,partof,FPLX,000417,RNApo_II +HGNC,3535,F2,partof,FPLX,000469,Thrombin_antithrombin +HGNC,775,SERPINC1,partof,FPLX,000469,Thrombin_antithrombin +HGNC,11532,TAF1A,partof,FPLX,000471,TIF_IB +HGNC,11533,TAF1B,partof,FPLX,000471,TIF_IB +HGNC,11534,TAF1C,partof,FPLX,000471,TIF_IB +HGNC,11588,TBP,partof,FPLX,000471,TIF_IB +HGNC,18752,MAPKAP1,partof,FPLX,000294,mTORC2 +HGNC,3942,MTOR,partof,FPLX,000294,mTORC2 +HGNC,28611,RICTOR,partof,FPLX,000294,mTORC2 +HGNC,24825,MLST8,partof,FPLX,000294,mTORC2 +HGNC,3942,MTOR,partof,FPLX,000293,mTORC1 +HGNC,30287,RPTOR,partof,FPLX,000293,mTORC1 +HGNC,11998,TP53,isa,FPLX,000327,p53_family +HGNC,15979,TP63,isa,FPLX,000327,p53_family +HGNC,12003,TP73,isa,FPLX,000327,p53_family +HGNC,9585,PTCH1,isa,FPLX,000333,Patched +HGNC,9586,PTCH2,isa,FPLX,000333,Patched +HGNC,11943,TNNC1,isa,FPLX,000478,Troponin_C +HGNC,11944,TNNC2,isa,FPLX,000478,Troponin_C +HGNC,11945,TNNI1,isa,FPLX,000479,Troponin_I +HGNC,11946,TNNI2,isa,FPLX,000479,Troponin_I +HGNC,11947,TNNI3,isa,FPLX,000479,Troponin_I +HGNC,11948,TNNT1,isa,FPLX,000480,Troponin_T +HGNC,11949,TNNT2,isa,FPLX,000480,Troponin_T +HGNC,11950,TNNT3,isa,FPLX,000480,Troponin_T +FPLX,000478,Troponin_C,partof,FPLX,000477,Troponin +FPLX,000479,Troponin_I,partof,FPLX,000477,Troponin +FPLX,000480,Troponin_T,partof,FPLX,000477,Troponin +HGNC,811,ATP2A1,isa,FPLX,000430,SERCA +HGNC,812,ATP2A2,isa,FPLX,000430,SERCA +HGNC,813,ATP2A3,isa,FPLX,000430,SERCA +HGNC,8014,YBX1,isa,FPLX,000498,YBX +HGNC,17948,YBX2,isa,FPLX,000498,YBX +HGNC,2428,YBX3,isa,FPLX,000498,YBX +HGNC,1925,CHEK1,isa,FPLX,000098,CHEK +HGNC,16627,CHEK2,isa,FPLX,000098,CHEK +HGNC,270,PARP1,isa,FPLX,000331,PARP +HGNC,272,PARP2,isa,FPLX,000331,PARP 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+HGNC,14049,MRPS14,partof,FPLX,000289,MRPS +HGNC,14504,MRPS15,partof,FPLX,000289,MRPS +HGNC,14048,MRPS16,partof,FPLX,000289,MRPS +HGNC,14047,MRPS17,partof,FPLX,000289,MRPS +HGNC,14515,MRPS18A,partof,FPLX,000289,MRPS +HGNC,14516,MRPS18B,partof,FPLX,000289,MRPS +HGNC,16633,MRPS18C,partof,FPLX,000289,MRPS +HGNC,14046,MRPS21,partof,FPLX,000289,MRPS +HGNC,14508,MRPS22,partof,FPLX,000289,MRPS +HGNC,14509,MRPS23,partof,FPLX,000289,MRPS +HGNC,14510,MRPS24,partof,FPLX,000289,MRPS +HGNC,14511,MRPS25,partof,FPLX,000289,MRPS +HGNC,14045,MRPS26,partof,FPLX,000289,MRPS +HGNC,14512,MRPS27,partof,FPLX,000289,MRPS +HGNC,14513,MRPS28,partof,FPLX,000289,MRPS +HGNC,2673,DAP3,partof,FPLX,000289,MRPS +HGNC,8769,MRPS30,partof,FPLX,000289,MRPS +HGNC,16632,MRPS31,partof,FPLX,000289,MRPS +HGNC,16634,MRPS33,partof,FPLX,000289,MRPS +HGNC,16618,MRPS34,partof,FPLX,000289,MRPS +HGNC,16635,MRPS35,partof,FPLX,000289,MRPS +HGNC,16631,MRPS36,partof,FPLX,000289,MRPS +FPLX,000289,MRPS,partof,FPLX,000288,Mitochondrial_Ribosome +FPLX,000290,MRPL,partof,FPLX,000288,Mitochondrial_Ribosome +HGNC,7939,NPPA,isa,FPLX,000304,Natriuretic_peptide +HGNC,7940,NPPB,isa,FPLX,000304,Natriuretic_peptide +HGNC,7941,NPPC,isa,FPLX,000304,Natriuretic_peptide +HGNC,7455,MT-ND1,partof,FPLX,000499,ETC_complex_I_core +HGNC,7456,MT-ND2,partof,FPLX,000499,ETC_complex_I_core +HGNC,7458,MT-ND3,partof,FPLX,000499,ETC_complex_I_core +HGNC,7459,MT-ND4,partof,FPLX,000499,ETC_complex_I_core +HGNC,7460,MT-ND4L,partof,FPLX,000499,ETC_complex_I_core +HGNC,7461,MT-ND5,partof,FPLX,000499,ETC_complex_I_core +HGNC,7462,MT-ND6,partof,FPLX,000499,ETC_complex_I_core +HGNC,7707,NDUFS1,partof,FPLX,000499,ETC_complex_I_core +HGNC,7708,NDUFS2,partof,FPLX,000499,ETC_complex_I_core +HGNC,7710,NDUFS3,partof,FPLX,000499,ETC_complex_I_core +HGNC,7714,NDUFS7,partof,FPLX,000499,ETC_complex_I_core +HGNC,7715,NDUFS8,partof,FPLX,000499,ETC_complex_I_core +HGNC,7716,NDUFV1,partof,FPLX,000499,ETC_complex_I_core +HGNC,7717,NDUFV2,partof,FPLX,000499,ETC_complex_I_core +HGNC,7694,NDUFAB1,partof,FPLX,000500,ETC_complex_I_supernumerary +HGNC,7683,NDUFA1,partof,FPLX,000500,ETC_complex_I_supernumerary +HGNC,7685,NDUFA2,partof,FPLX,000500,ETC_complex_I_supernumerary +HGNC,7686,NDUFA3,partof,FPLX,000500,ETC_complex_I_supernumerary +HGNC,7688,NDUFA5,partof,FPLX,000500,ETC_complex_I_supernumerary +HGNC,7690,NDUFA6,partof,FPLX,000500,ETC_complex_I_supernumerary +HGNC,7691,NDUFA7,partof,FPLX,000500,ETC_complex_I_supernumerary +HGNC,7692,NDUFA8,partof,FPLX,000500,ETC_complex_I_supernumerary +HGNC,7693,NDUFA9,partof,FPLX,000500,ETC_complex_I_supernumerary +HGNC,7684,NDUFA10,partof,FPLX,000500,ETC_complex_I_supernumerary +HGNC,20371,NDUFA11,partof,FPLX,000500,ETC_complex_I_supernumerary +HGNC,23987,NDUFA12,partof,FPLX,000500,ETC_complex_I_supernumerary +HGNC,17194,NDUFA13,partof,FPLX,000500,ETC_complex_I_supernumerary +HGNC,7695,NDUFB1,partof,FPLX,000500,ETC_complex_I_supernumerary +HGNC,7697,NDUFB2,partof,FPLX,000500,ETC_complex_I_supernumerary +HGNC,7698,NDUFB3,partof,FPLX,000500,ETC_complex_I_supernumerary +HGNC,7699,NDUFB4,partof,FPLX,000500,ETC_complex_I_supernumerary +HGNC,7700,NDUFB5,partof,FPLX,000500,ETC_complex_I_supernumerary +HGNC,7701,NDUFB6,partof,FPLX,000500,ETC_complex_I_supernumerary +HGNC,7702,NDUFB7,partof,FPLX,000500,ETC_complex_I_supernumerary +HGNC,7703,NDUFB8,partof,FPLX,000500,ETC_complex_I_supernumerary +HGNC,7704,NDUFB9,partof,FPLX,000500,ETC_complex_I_supernumerary +HGNC,7696,NDUFB10,partof,FPLX,000500,ETC_complex_I_supernumerary +HGNC,20372,NDUFB11,partof,FPLX,000500,ETC_complex_I_supernumerary +HGNC,7705,NDUFC1,partof,FPLX,000500,ETC_complex_I_supernumerary +HGNC,7706,NDUFC2,partof,FPLX,000500,ETC_complex_I_supernumerary +HGNC,7711,NDUFS4,partof,FPLX,000500,ETC_complex_I_supernumerary +HGNC,7712,NDUFS5,partof,FPLX,000500,ETC_complex_I_supernumerary +HGNC,7713,NDUFS6,partof,FPLX,000500,ETC_complex_I_supernumerary +HGNC,7719,NDUFV3,partof,FPLX,000500,ETC_complex_I_supernumerary +FPLX,000499,ETC_complex_I_core,partof,FPLX,000501,ETC_complex_I +FPLX,000500,ETC_complex_I_supernumerary,partof,FPLX,000501,ETC_complex_I +HGNC,10680,SDHA,partof,FPLX,000502,ETC_complex_II +HGNC,10681,SDHB,partof,FPLX,000502,ETC_complex_II +HGNC,10682,SDHC,partof,FPLX,000502,ETC_complex_II +HGNC,10683,SDHD,partof,FPLX,000502,ETC_complex_II +HGNC,2579,CYC1,partof,FPLX,000503,ETC_complex_III +HGNC,7427,MT-CYB,partof,FPLX,000503,ETC_complex_III +HGNC,12582,UQCRB,partof,FPLX,000503,ETC_complex_III +HGNC,12585,UQCRC1,partof,FPLX,000503,ETC_complex_III +HGNC,12586,UQCRC2,partof,FPLX,000503,ETC_complex_III +HGNC,12587,UQCRFS1,partof,FPLX,000503,ETC_complex_III +HGNC,12590,UQCRH,partof,FPLX,000503,ETC_complex_III +HGNC,29594,UQCRQ,partof,FPLX,000503,ETC_complex_III +HGNC,30863,UQCR10,partof,FPLX,000503,ETC_complex_III +HGNC,30862,UQCR11,partof,FPLX,000503,ETC_complex_III +HGNC,2265,COX4I1,partof,FPLX,000504,ETC_complex_IV +HGNC,16232,COX4I2,partof,FPLX,000504,ETC_complex_IV +HGNC,2267,COX5A,partof,FPLX,000504,ETC_complex_IV +HGNC,2269,COX5B,partof,FPLX,000504,ETC_complex_IV +HGNC,2277,COX6A1,partof,FPLX,000504,ETC_complex_IV +HGNC,2279,COX6A2,partof,FPLX,000504,ETC_complex_IV +HGNC,2280,COX6B1,partof,FPLX,000504,ETC_complex_IV +HGNC,24380,COX6B2,partof,FPLX,000504,ETC_complex_IV +HGNC,2285,COX6C,partof,FPLX,000504,ETC_complex_IV +HGNC,2287,COX7A1,partof,FPLX,000504,ETC_complex_IV +HGNC,2288,COX7A2,partof,FPLX,000504,ETC_complex_IV +HGNC,2291,COX7B,partof,FPLX,000504,ETC_complex_IV +HGNC,24381,COX7B2,partof,FPLX,000504,ETC_complex_IV +HGNC,2292,COX7C,partof,FPLX,000504,ETC_complex_IV +HGNC,2294,COX8A,partof,FPLX,000504,ETC_complex_IV +HGNC,24382,COX8C,partof,FPLX,000504,ETC_complex_IV +HGNC,7419,MT-CO1,partof,FPLX,000504,ETC_complex_IV +HGNC,7421,MT-CO2,partof,FPLX,000504,ETC_complex_IV +HGNC,7422,MT-CO3,partof,FPLX,000504,ETC_complex_IV +HGNC,823,ATP5F1A,partof,FPLX,000060,ATP_synthase +HGNC,830,ATP5F1B,partof,FPLX,000060,ATP_synthase +HGNC,833,ATP5F1C,partof,FPLX,000060,ATP_synthase +HGNC,837,ATP5F1D,partof,FPLX,000060,ATP_synthase +HGNC,838,ATP5F1E,partof,FPLX,000060,ATP_synthase +HGNC,30889,ATP5MD,partof,FPLX,000060,ATP_synthase +HGNC,846,ATP5ME,partof,FPLX,000060,ATP_synthase +HGNC,848,ATP5MF,partof,FPLX,000060,ATP_synthase +HGNC,14247,ATP5MG,partof,FPLX,000060,ATP_synthase +HGNC,1188,ATP5MPL,partof,FPLX,000060,ATP_synthase +HGNC,7414,MT-ATP6,partof,FPLX,000060,ATP_synthase +HGNC,7415,MT-ATP8,partof,FPLX,000060,ATP_synthase +HGNC,840,ATP5PB,partof,FPLX,000060,ATP_synthase +HGNC,845,ATP5PD,partof,FPLX,000060,ATP_synthase +HGNC,847,ATP5PF,partof,FPLX,000060,ATP_synthase +HGNC,850,ATP5PO,partof,FPLX,000060,ATP_synthase +HGNC,871,ATP5IF1,partof,FPLX,000060,ATP_synthase +HGNC,841,ATP5MC1,isa,FPLX,000059,ATP5G +HGNC,842,ATP5MC2,isa,FPLX,000059,ATP5G +HGNC,843,ATP5MC3,isa,FPLX,000059,ATP5G +FPLX,000059,ATP5G,partof,FPLX,000060,ATP_synthase +HGNC,7393,MT1A,isa,FPLX,000292,Metallothionein +HGNC,7394,MT1B,isa,FPLX,000292,Metallothionein +HGNC,7395,MT1CP,isa,FPLX,000292,Metallothionein +HGNC,7396,MT1DP,isa,FPLX,000292,Metallothionein +HGNC,7397,MT1E,isa,FPLX,000292,Metallothionein +HGNC,7398,MT1F,isa,FPLX,000292,Metallothionein +HGNC,7399,MT1G,isa,FPLX,000292,Metallothionein +HGNC,7400,MT1H,isa,FPLX,000292,Metallothionein +HGNC,31864,MT1HL1,isa,FPLX,000292,Metallothionein +HGNC,7401,MT1IP,isa,FPLX,000292,Metallothionein +HGNC,7402,MT1JP,isa,FPLX,000292,Metallothionein +HGNC,7404,MT1L,isa,FPLX,000292,Metallothionein +HGNC,14296,MT1M,isa,FPLX,000292,Metallothionein +HGNC,23681,MT1P1,isa,FPLX,000292,Metallothionein +HGNC,16120,MT1P3,isa,FPLX,000292,Metallothionein +HGNC,7405,MT1X,isa,FPLX,000292,Metallothionein +HGNC,7406,MT2A,isa,FPLX,000292,Metallothionein +HGNC,7408,MT3,isa,FPLX,000292,Metallothionein +HGNC,18705,MT4,isa,FPLX,000292,Metallothionein +HGNC,660,TRIM23,isa,FPLX,000053,ARF_GTPase_family +HGNC,652,ARF1,isa,FPLX,000053,ARF_GTPase_family +HGNC,654,ARF3,isa,FPLX,000053,ARF_GTPase_family +HGNC,655,ARF4,isa,FPLX,000053,ARF_GTPase_family +HGNC,658,ARF5,isa,FPLX,000053,ARF_GTPase_family +HGNC,659,ARF6,isa,FPLX,000053,ARF_GTPase_family +HGNC,692,ARL1,isa,FPLX,000053,ARF_GTPase_family +HGNC,693,ARL2,isa,FPLX,000053,ARF_GTPase_family +HGNC,694,ARL3,isa,FPLX,000053,ARF_GTPase_family +HGNC,695,ARL4A,isa,FPLX,000053,ARF_GTPase_family +HGNC,698,ARL4C,isa,FPLX,000053,ARF_GTPase_family +HGNC,656,ARL4D,isa,FPLX,000053,ARF_GTPase_family +HGNC,696,ARL5A,isa,FPLX,000053,ARF_GTPase_family +HGNC,23052,ARL5B,isa,FPLX,000053,ARF_GTPase_family +HGNC,31111,ARL5C,isa,FPLX,000053,ARF_GTPase_family +HGNC,13210,ARL6,isa,FPLX,000053,ARF_GTPase_family +HGNC,25192,ARL8A,isa,FPLX,000053,ARF_GTPase_family +HGNC,25564,ARL8B,isa,FPLX,000053,ARF_GTPase_family +HGNC,23592,ARL9,isa,FPLX,000053,ARF_GTPase_family +HGNC,22042,ARL10,isa,FPLX,000053,ARF_GTPase_family +HGNC,24046,ARL11,isa,FPLX,000053,ARF_GTPase_family +HGNC,31709,ARL13A,isa,FPLX,000053,ARF_GTPase_family +HGNC,25419,ARL13B,isa,FPLX,000053,ARF_GTPase_family +HGNC,22974,ARL14,isa,FPLX,000053,ARF_GTPase_family +HGNC,25945,ARL15,isa,FPLX,000053,ARF_GTPase_family +HGNC,27902,ARL16,isa,FPLX,000053,ARF_GTPase_family +HGNC,24096,ARL17A,isa,FPLX,000053,ARF_GTPase_family +HGNC,32387,ARL17B,isa,FPLX,000053,ARF_GTPase_family +HGNC,662,ARFRP1,isa,FPLX,000053,ARF_GTPase_family +HGNC,10534,SAR1A,isa,FPLX,000053,ARF_GTPase_family +HGNC,10535,SAR1B,isa,FPLX,000053,ARF_GTPase_family +FPLX,000002,A4GALT_family,isa,FPLX,000198,Glycosyltransferase +FPLX,000026,ALG10,isa,FPLX,000198,Glycosyltransferase +FPLX,000027,ALG1_family,isa,FPLX,000198,Glycosyltransferase +FPLX,000028,ALG3_family,isa,FPLX,000198,Glycosyltransferase +FPLX,000029,ALG6_family,isa,FPLX,000198,Glycosyltransferase +FPLX,000030,ALG13_family,isa,FPLX,000198,Glycosyltransferase +FPLX,000063,B3GAT,isa,FPLX,000198,Glycosyltransferase +FPLX,000065,Beta_3_4_GTF,isa,FPLX,000198,Glycosyltransferase +FPLX,000112,COLGALT,isa,FPLX,000198,Glycosyltransferase +FPLX,000165,EXT,isa,FPLX,000198,Glycosyltransferase +FPLX,000176,FUT,isa,FPLX,000198,Glycosyltransferase +FPLX,000180,GALNT,isa,FPLX,000198,Glycosyltransferase +FPLX,000185,GCNT,isa,FPLX,000198,Glycosyltransferase +FPLX,000199,GTF_family_2,isa,FPLX,000198,Glycosyltransferase +FPLX,000200,GTF_family_6,isa,FPLX,000198,Glycosyltransferase +FPLX,000201,GTF_family_8,isa,FPLX,000198,Glycosyltransferase +FPLX,000202,GTF_family_29,isa,FPLX,000198,Glycosyltransferase +FPLX,000203,GTF_family_90,isa,FPLX,000198,Glycosyltransferase +FPLX,000287,MGAT,isa,FPLX,000198,Glycosyltransferase +FPLX,000322,OGT_family,isa,FPLX,000198,Glycosyltransferase +FPLX,000396,PYG,isa,FPLX,000198,Glycosyltransferase +FPLX,000455,STT3,isa,FPLX,000198,Glycosyltransferase +FPLX,000491,UGCG,isa,FPLX,000198,Glycosyltransferase +FPLX,000492,UGT,isa,FPLX,000198,Glycosyltransferase +FPLX,000493,UGGT,isa,FPLX,000198,Glycosyltransferase +HGNC,23162,ALG10,isa,FPLX,000026,ALG10 +HGNC,31088,ALG10B,isa,FPLX,000026,ALG10 +HGNC,23157,ALG6,isa,FPLX,000029,ALG6_family +HGNC,23161,ALG8,isa,FPLX,000029,ALG6_family +HGNC,18149,A4GALT,isa,FPLX,000002,A4GALT_family +HGNC,17968,A4GNT,isa,FPLX,000002,A4GALT_family +HGNC,921,B3GAT1,isa,FPLX,000063,B3GAT +HGNC,922,B3GAT2,isa,FPLX,000063,B3GAT +HGNC,923,B3GAT3,isa,FPLX,000063,B3GAT +HGNC,918,B3GALNT1,isa,FPLX,000065,Beta_3_4_GTF +HGNC,28596,B3GALNT2,isa,FPLX,000065,Beta_3_4_GTF +HGNC,20207,B3GLCT,isa,FPLX,000065,Beta_3_4_GTF +HGNC,916,B3GALT1,isa,FPLX,000065,Beta_3_4_GTF +HGNC,917,B3GALT2,isa,FPLX,000065,Beta_3_4_GTF +HGNC,919,B3GALT4,isa,FPLX,000065,Beta_3_4_GTF +HGNC,920,B3GALT5,isa,FPLX,000065,Beta_3_4_GTF +HGNC,17978,B3GALT6,isa,FPLX,000065,Beta_3_4_GTF +HGNC,15629,B3GNT2,isa,FPLX,000065,Beta_3_4_GTF +HGNC,13528,B3GNT3,isa,FPLX,000065,Beta_3_4_GTF +HGNC,15683,B3GNT4,isa,FPLX,000065,Beta_3_4_GTF +HGNC,15684,B3GNT5,isa,FPLX,000065,Beta_3_4_GTF +HGNC,24141,B3GNT6,isa,FPLX,000065,Beta_3_4_GTF +HGNC,18811,B3GNT7,isa,FPLX,000065,Beta_3_4_GTF +HGNC,24139,B3GNT8,isa,FPLX,000065,Beta_3_4_GTF +HGNC,28714,B3GNT9,isa,FPLX,000065,Beta_3_4_GTF +HGNC,24291,CHPF,isa,FPLX,000065,Beta_3_4_GTF +HGNC,29270,CHPF2,isa,FPLX,000065,Beta_3_4_GTF +HGNC,17198,CHSY1,isa,FPLX,000065,Beta_3_4_GTF +HGNC,24293,CHSY3,isa,FPLX,000065,Beta_3_4_GTF +HGNC,24337,C1GALT1,isa,FPLX,000065,Beta_3_4_GTF +HGNC,6560,LFNG,isa,FPLX,000065,Beta_3_4_GTF +HGNC,7038,MFNG,isa,FPLX,000065,Beta_3_4_GTF +HGNC,9974,RFNG,isa,FPLX,000065,Beta_3_4_GTF +HGNC,4117,B4GALNT1,isa,FPLX,000065,Beta_3_4_GTF +HGNC,24136,B4GALNT2,isa,FPLX,000065,Beta_3_4_GTF +HGNC,24137,B4GALNT3,isa,FPLX,000065,Beta_3_4_GTF +HGNC,26315,B4GALNT4,isa,FPLX,000065,Beta_3_4_GTF +HGNC,924,B4GALT1,isa,FPLX,000065,Beta_3_4_GTF +HGNC,925,B4GALT2,isa,FPLX,000065,Beta_3_4_GTF +HGNC,926,B4GALT3,isa,FPLX,000065,Beta_3_4_GTF +HGNC,927,B4GALT4,isa,FPLX,000065,Beta_3_4_GTF +HGNC,928,B4GALT5,isa,FPLX,000065,Beta_3_4_GTF +HGNC,929,B4GALT6,isa,FPLX,000065,Beta_3_4_GTF +HGNC,930,B4GALT7,isa,FPLX,000065,Beta_3_4_GTF +HGNC,24290,CSGALNACT1,isa,FPLX,000065,Beta_3_4_GTF +HGNC,24292,CSGALNACT2,isa,FPLX,000065,Beta_3_4_GTF +HGNC,26182,COLGALT1,isa,FPLX,000112,COLGALT +HGNC,16790,COLGALT2,isa,FPLX,000112,COLGALT +HGNC,23056,ALG3,isa,FPLX,000028,ALG3_family +HGNC,15672,ALG9,isa,FPLX,000028,ALG3_family +HGNC,19358,ALG12,isa,FPLX,000028,ALG3_family +HGNC,8959,PIGB,isa,FPLX,000028,ALG3_family +HGNC,18858,PIGM,isa,FPLX,000028,ALG3_family +HGNC,26031,PIGV,isa,FPLX,000028,ALG3_family +HGNC,30596,PIGZ,isa,FPLX,000028,ALG3_family +HGNC,9202,POMT1,isa,FPLX,000028,ALG3_family +HGNC,19743,POMT2,isa,FPLX,000028,ALG3_family +HGNC,3515,EXTL1,isa,FPLX,000165,EXT +HGNC,3516,EXTL2,isa,FPLX,000165,EXT +HGNC,3518,EXTL3,isa,FPLX,000165,EXT +HGNC,3512,EXT1,isa,FPLX,000165,EXT +HGNC,3513,EXT2,isa,FPLX,000165,EXT +HGNC,4012,FUT1,isa,FPLX,000176,FUT +HGNC,4013,FUT2,isa,FPLX,000176,FUT +HGNC,4014,FUT3,isa,FPLX,000176,FUT +HGNC,4015,FUT4,isa,FPLX,000176,FUT +HGNC,4016,FUT5,isa,FPLX,000176,FUT +HGNC,4017,FUT6,isa,FPLX,000176,FUT +HGNC,4018,FUT7,isa,FPLX,000176,FUT +HGNC,4019,FUT8,isa,FPLX,000176,FUT +HGNC,4020,FUT9,isa,FPLX,000176,FUT +HGNC,19234,FUT10,isa,FPLX,000176,FUT +HGNC,19233,FUT11,isa,FPLX,000176,FUT +HGNC,14988,POFUT1,isa,FPLX,000176,FUT +HGNC,14683,POFUT2,isa,FPLX,000176,FUT +HGNC,4203,GCNT1,isa,FPLX,000185,GCNT +HGNC,4204,GCNT2,isa,FPLX,000185,GCNT +HGNC,4205,GCNT3,isa,FPLX,000185,GCNT +HGNC,17973,GCNT4,isa,FPLX,000185,GCNT +HGNC,16099,GCNT7,isa,FPLX,000185,GCNT +HGNC,15516,XYLT1,isa,FPLX,000185,GCNT +HGNC,15517,XYLT2,isa,FPLX,000185,GCNT +HGNC,9723,PYGB,isa,FPLX,000396,PYG +HGNC,9725,PYGL,isa,FPLX,000396,PYG +HGNC,9726,PYGM,isa,FPLX,000396,PYG +HGNC,20266,ALG5,isa,FPLX,000199,GTF_family_2 +HGNC,21727,B3GNTL1,isa,FPLX,000199,GTF_family_2 +HGNC,3005,DPM1,isa,FPLX,000199,GTF_family_2 +HGNC,4818,HAS1,isa,FPLX,000199,GTF_family_2 +HGNC,4819,HAS2,isa,FPLX,000199,GTF_family_2 +HGNC,4820,HAS3,isa,FPLX,000199,GTF_family_2 +HGNC,79,ABO,isa,FPLX,000200,GTF_family_6 +HGNC,30005,A3GALT2,isa,FPLX,000200,GTF_family_6 +HGNC,20460,GBGT1,isa,FPLX,000200,GTF_family_6 +HGNC,23671,GLT6D1,isa,FPLX,000200,GTF_family_6 +HGNC,24870,GLT8D1,isa,FPLX,000201,GTF_family_8 +HGNC,24890,GLT8D2,isa,FPLX,000201,GTF_family_8 +HGNC,27482,GXYLT1,isa,FPLX,000201,GTF_family_8 +HGNC,33383,GXYLT2,isa,FPLX,000201,GTF_family_8 +HGNC,4699,GYG1,isa,FPLX,000201,GTF_family_8 +HGNC,4700,GYG2,isa,FPLX,000201,GTF_family_8 +HGNC,6511,LARGE1,isa,FPLX,000201,GTF_family_8 +HGNC,16522,LARGE2,isa,FPLX,000201,GTF_family_8 +HGNC,13530,RXYLT1,isa,FPLX,000201,GTF_family_8 +HGNC,26639,XXYLT1,isa,FPLX,000201,GTF_family_8 +HGNC,19350,POGLUT2,isa,FPLX,000203,GTF_family_90 +HGNC,28496,POGLUT3,isa,FPLX,000203,GTF_family_90 +HGNC,22954,POGLUT1,isa,FPLX,000203,GTF_family_90 +HGNC,18294,ALG1,isa,FPLX,000027,ALG1_family +HGNC,33721,ALG1L,isa,FPLX,000027,ALG1_family +HGNC,37258,ALG1L2,isa,FPLX,000027,ALG1_family +HGNC,23159,ALG2,isa,FPLX,000027,ALG1_family +HGNC,32456,ALG11,isa,FPLX,000027,ALG1_family +HGNC,26483,GLT1D1,isa,FPLX,000027,ALG1_family +HGNC,20887,GTDC1,isa,FPLX,000027,ALG1_family +HGNC,4706,GYS1,isa,FPLX,000027,ALG1_family +HGNC,4707,GYS2,isa,FPLX,000027,ALG1_family +HGNC,8957,PIGA,isa,FPLX,000027,ALG1_family +HGNC,7044,MGAT1,isa,FPLX,000287,MGAT +HGNC,7045,MGAT2,isa,FPLX,000287,MGAT +HGNC,7046,MGAT3,isa,FPLX,000287,MGAT +HGNC,7047,MGAT4A,isa,FPLX,000287,MGAT +HGNC,7048,MGAT4B,isa,FPLX,000287,MGAT +HGNC,30871,MGAT4C,isa,FPLX,000287,MGAT +HGNC,43619,MGAT4D,isa,FPLX,000287,MGAT +HGNC,7049,MGAT5,isa,FPLX,000287,MGAT +HGNC,24140,MGAT5B,isa,FPLX,000287,MGAT +HGNC,28526,EOGT,isa,FPLX,000322,OGT_family +HGNC,8127,OGT,isa,FPLX,000322,OGT_family +HGNC,19139,POMGNT1,isa,FPLX,000322,OGT_family +HGNC,25902,POMGNT2,isa,FPLX,000322,OGT_family +HGNC,21725,GALNTL5,isa,FPLX,000180,GALNT +HGNC,33844,GALNTL6,isa,FPLX,000180,GALNT +HGNC,4123,GALNT1,isa,FPLX,000180,GALNT +HGNC,4124,GALNT2,isa,FPLX,000180,GALNT +HGNC,4125,GALNT3,isa,FPLX,000180,GALNT +HGNC,4126,GALNT4,isa,FPLX,000180,GALNT +HGNC,4127,GALNT5,isa,FPLX,000180,GALNT +HGNC,4128,GALNT6,isa,FPLX,000180,GALNT +HGNC,4129,GALNT7,isa,FPLX,000180,GALNT +HGNC,4130,GALNT8,isa,FPLX,000180,GALNT +HGNC,4131,GALNT9,isa,FPLX,000180,GALNT +HGNC,19873,GALNT10,isa,FPLX,000180,GALNT +HGNC,19875,GALNT11,isa,FPLX,000180,GALNT +HGNC,19877,GALNT12,isa,FPLX,000180,GALNT +HGNC,23242,GALNT13,isa,FPLX,000180,GALNT +HGNC,22946,GALNT14,isa,FPLX,000180,GALNT +HGNC,21531,GALNT15,isa,FPLX,000180,GALNT +HGNC,23233,GALNT16,isa,FPLX,000180,GALNT +HGNC,30488,GALNT18,isa,FPLX,000180,GALNT +HGNC,16347,GALNT17,isa,FPLX,000180,GALNT +HGNC,10862,ST3GAL1,isa,FPLX,000202,GTF_family_29 +HGNC,10863,ST3GAL2,isa,FPLX,000202,GTF_family_29 +HGNC,10866,ST3GAL3,isa,FPLX,000202,GTF_family_29 +HGNC,10864,ST3GAL4,isa,FPLX,000202,GTF_family_29 +HGNC,10872,ST3GAL5,isa,FPLX,000202,GTF_family_29 +HGNC,18080,ST3GAL6,isa,FPLX,000202,GTF_family_29 +HGNC,23614,ST6GALNAC1,isa,FPLX,000202,GTF_family_29 +HGNC,10867,ST6GALNAC2,isa,FPLX,000202,GTF_family_29 +HGNC,19343,ST6GALNAC3,isa,FPLX,000202,GTF_family_29 +HGNC,17846,ST6GALNAC4,isa,FPLX,000202,GTF_family_29 +HGNC,19342,ST6GALNAC5,isa,FPLX,000202,GTF_family_29 +HGNC,23364,ST6GALNAC6,isa,FPLX,000202,GTF_family_29 +HGNC,10860,ST6GAL1,isa,FPLX,000202,GTF_family_29 +HGNC,10861,ST6GAL2,isa,FPLX,000202,GTF_family_29 +HGNC,10869,ST8SIA1,isa,FPLX,000202,GTF_family_29 +HGNC,10870,ST8SIA2,isa,FPLX,000202,GTF_family_29 +HGNC,14269,ST8SIA3,isa,FPLX,000202,GTF_family_29 +HGNC,10871,ST8SIA4,isa,FPLX,000202,GTF_family_29 +HGNC,17827,ST8SIA5,isa,FPLX,000202,GTF_family_29 +HGNC,23317,ST8SIA6,isa,FPLX,000202,GTF_family_29 +HGNC,6172,STT3A,isa,FPLX,000455,STT3 +HGNC,30611,STT3B,isa,FPLX,000455,STT3 +HGNC,12524,UGCG,isa,FPLX,000491,UGCG +HGNC,15663,UGGT1,isa,FPLX,000493,UGGT +HGNC,15664,UGGT2,isa,FPLX,000493,UGGT +HGNC,12529,UGT1A,isa,FPLX,000492,UGT +HGNC,12530,UGT1A1,isa,FPLX,000492,UGT +HGNC,12534,UGT1A2P,isa,FPLX,000492,UGT +HGNC,12535,UGT1A3,isa,FPLX,000492,UGT +HGNC,12536,UGT1A4,isa,FPLX,000492,UGT +HGNC,12537,UGT1A5,isa,FPLX,000492,UGT +HGNC,12538,UGT1A6,isa,FPLX,000492,UGT +HGNC,12539,UGT1A7,isa,FPLX,000492,UGT +HGNC,12540,UGT1A8,isa,FPLX,000492,UGT +HGNC,12541,UGT1A9,isa,FPLX,000492,UGT +HGNC,12531,UGT1A10,isa,FPLX,000492,UGT +HGNC,12532,UGT1A11P,isa,FPLX,000492,UGT +HGNC,12533,UGT1A12P,isa,FPLX,000492,UGT +HGNC,32191,UGT1A13P,isa,FPLX,000492,UGT +HGNC,12542,UGT2A1,isa,FPLX,000492,UGT +HGNC,28183,UGT2A2,isa,FPLX,000492,UGT +HGNC,28528,UGT2A3,isa,FPLX,000492,UGT +HGNC,12553,UGT2B4,isa,FPLX,000492,UGT +HGNC,12554,UGT2B7,isa,FPLX,000492,UGT +HGNC,12544,UGT2B10,isa,FPLX,000492,UGT +HGNC,12545,UGT2B11,isa,FPLX,000492,UGT +HGNC,12546,UGT2B15,isa,FPLX,000492,UGT +HGNC,12547,UGT2B17,isa,FPLX,000492,UGT +HGNC,12548,UGT2B24P,isa,FPLX,000492,UGT +HGNC,12549,UGT2B25P,isa,FPLX,000492,UGT +HGNC,12550,UGT2B26P,isa,FPLX,000492,UGT +HGNC,12551,UGT2B27P,isa,FPLX,000492,UGT +HGNC,13479,UGT2B28,isa,FPLX,000492,UGT +HGNC,12552,UGT2B29P,isa,FPLX,000492,UGT +HGNC,26625,UGT3A1,isa,FPLX,000492,UGT +HGNC,27266,UGT3A2,isa,FPLX,000492,UGT +HGNC,12555,UGT8,isa,FPLX,000492,UGT +HGNC,30881,ALG13,isa,FPLX,000030,ALG13_family +HGNC,28287,ALG14,isa,FPLX,000030,ALG13_family +HGNC,9855,RAP1A,isa,FPLX,000401,RAP1 +HGNC,9857,RAP1B,isa,FPLX,000401,RAP1 +HGNC,11142,SIK1,isa,FPLX,000433,SIK +HGNC,21680,SIK2,isa,FPLX,000433,SIK +HGNC,29165,SIK3,isa,FPLX,000433,SIK +HGNC,3091,DYRK1A,isa,FPLX,000146,DYRK +HGNC,3092,DYRK1B,isa,FPLX,000146,DYRK +HGNC,3093,DYRK2,isa,FPLX,000146,DYRK +HGNC,3094,DYRK3,isa,FPLX,000146,DYRK +HGNC,3095,DYRK4,isa,FPLX,000146,DYRK +HGNC,25174,HAUS1,partof,FPLX,000061,Augmin +HGNC,25530,HAUS2,partof,FPLX,000061,Augmin +HGNC,28719,HAUS3,partof,FPLX,000061,Augmin +HGNC,20163,HAUS4,partof,FPLX,000061,Augmin +HGNC,29130,HAUS5,partof,FPLX,000061,Augmin +HGNC,25948,HAUS6,partof,FPLX,000061,Augmin +HGNC,32979,HAUS7,partof,FPLX,000061,Augmin +HGNC,30532,HAUS8,partof,FPLX,000061,Augmin +HGNC,16062,CRTC1,isa,FPLX,000123,CRTC +HGNC,27301,CRTC2,isa,FPLX,000123,CRTC +HGNC,26148,CRTC3,isa,FPLX,000123,CRTC diff --git a/famplex/resources/relations.tsv b/famplex/resources/relations.tsv deleted file mode 100644 index b9a29f52f..000000000 --- a/famplex/resources/relations.tsv +++ /dev/null @@ -1,2784 +0,0 @@ -HGNC 3288 EIF4EBP1 isa FPLX 000154 EIF4EBP -HGNC 3289 EIF4EBP2 isa FPLX 000154 EIF4EBP -HGNC 3290 EIF4EBP3 isa FPLX 000154 EIF4EBP -HGNC 129 ACTA1 isa FPLX 000009 Actin -HGNC 130 ACTA2 isa FPLX 000009 Actin -HGNC 132 ACTB isa FPLX 000009 Actin -HGNC 143 ACTC1 isa FPLX 000009 Actin -HGNC 144 ACTG1 isa FPLX 000009 Actin -HGNC 145 ACTG2 isa FPLX 000009 Actin -FPLX 000011 Activin_A isa FPLX 000010 Activin -FPLX 000012 Activin_AB isa FPLX 000010 Activin -FPLX 000013 Activin_B isa FPLX 000010 Activin -FPLX 000257 Inhibin_A isa FPLX 000256 Inhibin -FPLX 000258 Inhibin_B isa FPLX 000256 Inhibin -HGNC 6066 INHBA partof FPLX 000011 Activin_A -HGNC 6066 INHBA partof FPLX 000012 Activin_AB -HGNC 6067 INHBB partof FPLX 000012 Activin_AB -HGNC 6067 INHBB partof FPLX 000013 Activin_B -HGNC 6065 INHA partof FPLX 000257 Inhibin_A -HGNC 6066 INHBA partof FPLX 000257 Inhibin_A -HGNC 6065 INHA partof FPLX 000258 Inhibin_B -HGNC 6067 INHBB partof FPLX 000258 Inhibin_B -HGNC 391 AKT1 isa FPLX 000023 AKT -HGNC 392 AKT2 isa FPLX 000023 AKT -HGNC 393 AKT3 isa FPLX 000023 AKT -FPLX 000044 AMPK_alpha partof FPLX 000031 AMPK -FPLX 000045 AMPK_beta partof FPLX 000031 AMPK -FPLX 000046 AMPK_gamma partof FPLX 000031 AMPK -HGNC 9376 PRKAA1 isa FPLX 000044 AMPK_alpha -HGNC 9377 PRKAA2 isa FPLX 000044 AMPK_alpha -HGNC 9378 PRKAB1 isa FPLX 000045 AMPK_beta -HGNC 9379 PRKAB2 isa FPLX 000045 AMPK_beta -HGNC 9385 PRKAG1 isa FPLX 000046 AMPK_gamma -HGNC 9386 PRKAG2 isa FPLX 000046 AMPK_gamma -HGNC 9387 PRKAG3 isa FPLX 000046 AMPK_gamma -FPLX 000032 AMPK_A1B1G1 isa FPLX 000031 AMPK -HGNC 9376 PRKAA1 partof FPLX 000032 AMPK_A1B1G1 -HGNC 9378 PRKAB1 partof FPLX 000032 AMPK_A1B1G1 -HGNC 9385 PRKAG1 partof FPLX 000032 AMPK_A1B1G1 -FPLX 000033 AMPK_A1B1G2 isa FPLX 000031 AMPK -HGNC 9376 PRKAA1 partof FPLX 000033 AMPK_A1B1G2 -HGNC 9378 PRKAB1 partof FPLX 000033 AMPK_A1B1G2 -HGNC 9386 PRKAG2 partof FPLX 000033 AMPK_A1B1G2 -FPLX 000034 AMPK_A1B1G3 isa FPLX 000031 AMPK -HGNC 9376 PRKAA1 partof FPLX 000034 AMPK_A1B1G3 -HGNC 9378 PRKAB1 partof FPLX 000034 AMPK_A1B1G3 -HGNC 9387 PRKAG3 partof FPLX 000034 AMPK_A1B1G3 -FPLX 000035 AMPK_A1B2G1 isa FPLX 000031 AMPK -HGNC 9376 PRKAA1 partof FPLX 000035 AMPK_A1B2G1 -HGNC 9379 PRKAB2 partof FPLX 000035 AMPK_A1B2G1 -HGNC 9385 PRKAG1 partof FPLX 000035 AMPK_A1B2G1 -FPLX 000036 AMPK_A1B2G2 isa FPLX 000031 AMPK -HGNC 9376 PRKAA1 partof FPLX 000036 AMPK_A1B2G2 -HGNC 9379 PRKAB2 partof FPLX 000036 AMPK_A1B2G2 -HGNC 9386 PRKAG2 partof FPLX 000036 AMPK_A1B2G2 -FPLX 000037 AMPK_A1B2G3 isa FPLX 000031 AMPK -HGNC 9376 PRKAA1 partof FPLX 000037 AMPK_A1B2G3 -HGNC 9379 PRKAB2 partof FPLX 000037 AMPK_A1B2G3 -HGNC 9387 PRKAG3 partof FPLX 000037 AMPK_A1B2G3 -FPLX 000038 AMPK_A2B1G1 isa FPLX 000031 AMPK -HGNC 9377 PRKAA2 partof FPLX 000038 AMPK_A2B1G1 -HGNC 9378 PRKAB1 partof FPLX 000038 AMPK_A2B1G1 -HGNC 9385 PRKAG1 partof FPLX 000038 AMPK_A2B1G1 -FPLX 000039 AMPK_A2B1G2 isa FPLX 000031 AMPK -HGNC 9377 PRKAA2 partof FPLX 000039 AMPK_A2B1G2 -HGNC 9378 PRKAB1 partof FPLX 000039 AMPK_A2B1G2 -HGNC 9386 PRKAG2 partof FPLX 000039 AMPK_A2B1G2 -FPLX 000040 AMPK_A2B1G3 isa FPLX 000031 AMPK -HGNC 9377 PRKAA2 partof FPLX 000040 AMPK_A2B1G3 -HGNC 9378 PRKAB1 partof FPLX 000040 AMPK_A2B1G3 -HGNC 9387 PRKAG3 partof FPLX 000040 AMPK_A2B1G3 -FPLX 000041 AMPK_A2B2G1 isa FPLX 000031 AMPK -HGNC 9377 PRKAA2 partof FPLX 000041 AMPK_A2B2G1 -HGNC 9379 PRKAB2 partof FPLX 000041 AMPK_A2B2G1 -HGNC 9385 PRKAG1 partof FPLX 000041 AMPK_A2B2G1 -FPLX 000042 AMPK_A2B2G2 isa FPLX 000031 AMPK -HGNC 9377 PRKAA2 partof FPLX 000042 AMPK_A2B2G2 -HGNC 9379 PRKAB2 partof FPLX 000042 AMPK_A2B2G2 -HGNC 9386 PRKAG2 partof FPLX 000042 AMPK_A2B2G2 -FPLX 000043 AMPK_A2B2G3 isa FPLX 000031 AMPK -HGNC 9377 PRKAA2 partof FPLX 000043 AMPK_A2B2G3 -HGNC 9379 PRKAB2 partof FPLX 000043 AMPK_A2B2G3 -HGNC 9387 PRKAG3 partof FPLX 000043 AMPK_A2B2G3 -HGNC 561 AP2A1 isa FPLX 000049 AP2A -HGNC 562 AP2A2 isa FPLX 000049 AP2A -HGNC 563 AP2B1 partof FPLX 000015 Adaptor_protein_II -HGNC 564 AP2M1 partof FPLX 000015 Adaptor_protein_II -HGNC 565 AP2S1 partof FPLX 000015 Adaptor_protein_II -FPLX 000049 AP2A partof FPLX 000015 Adaptor_protein_II -HGNC 3796 FOS isa FPLX 000173 FOS_family -HGNC 3797 FOSB isa FPLX 000173 FOS_family -HGNC 13718 FOSL1 isa FPLX 000173 FOS_family -HGNC 3798 FOSL2 isa FPLX 000173 FOS_family -FPLX 000173 FOS_family partof FPLX 000048 AP1 -HGNC 6204 JUN isa FPLX 000268 JUN_family -HGNC 6205 JUNB isa FPLX 000268 JUN_family -HGNC 6206 JUND isa FPLX 000268 JUN_family -FPLX 000268 JUN_family partof FPLX 000048 AP1 -HGNC 1499 CASP1 isa FPLX 000081 Caspase -HGNC 1503 CASP2 isa FPLX 000081 Caspase -HGNC 1504 CASP3 isa FPLX 000082 Caspase_3_7 -HGNC 1505 CASP4 isa FPLX 000081 Caspase -HGNC 1506 CASP5 isa FPLX 000081 Caspase -HGNC 1507 CASP6 isa FPLX 000081 Caspase -HGNC 1508 CASP7 isa FPLX 000082 Caspase_3_7 -HGNC 1509 CASP8 isa FPLX 000081 Caspase -HGNC 1511 CASP9 isa FPLX 000081 Caspase -HGNC 1500 CASP10 isa FPLX 000081 Caspase -HGNC 19004 CASP12 isa FPLX 000081 Caspase -HGNC 1502 CASP14 isa FPLX 000081 Caspase -FPLX 000082 Caspase_3_7 isa FPLX 000081 Caspase -HGNC 1781 CDKL1 isa FPLX 000092 CDK -HGNC 1782 CDKL2 isa FPLX 000092 CDK -HGNC 15483 CDKL3 isa FPLX 000092 CDK -HGNC 19287 CDKL4 isa FPLX 000092 CDK -HGNC 11411 CDKL5 isa FPLX 000092 CDK -HGNC 1722 CDK1 isa FPLX 000093 CDK1_2 -HGNC 1771 CDK2 isa FPLX 000093 CDK1_2 -FPLX 000093 CDK1_2 isa FPLX 000092 CDK -HGNC 1772 CDK3 isa FPLX 000092 CDK -HGNC 1773 CDK4 isa FPLX 000092 CDK -HGNC 1774 CDK5 isa FPLX 000092 CDK -HGNC 1777 CDK6 isa FPLX 000092 CDK -HGNC 1778 CDK7 isa FPLX 000092 CDK -HGNC 1779 CDK8 isa FPLX 000092 CDK -HGNC 1780 CDK9 isa FPLX 000092 CDK -HGNC 1770 CDK10 isa FPLX 000092 CDK -HGNC 1730 CDK11A isa FPLX 000092 CDK -HGNC 1729 CDK11B isa FPLX 000092 CDK -HGNC 24224 CDK12 isa FPLX 000092 CDK -HGNC 1733 CDK13 isa FPLX 000092 CDK -HGNC 8883 CDK14 isa FPLX 000092 CDK -HGNC 14434 CDK15 isa FPLX 000092 CDK -HGNC 8749 CDK16 isa FPLX 000092 CDK -HGNC 8750 CDK17 isa FPLX 000092 CDK -HGNC 8751 CDK18 isa FPLX 000092 CDK -HGNC 19338 CDK19 isa FPLX 000092 CDK -HGNC 21420 CDK20 isa FPLX 000092 CDK -HGNC 2457 CSNK2A1 isa FPLX 000125 CSNK2 -HGNC 2459 CSNK2A2 isa FPLX 000125 CSNK2 -HGNC 2457 CSNK2A1 partof FPLX 000104 CK2 -HGNC 2459 CSNK2A2 partof FPLX 000104 CK2 -HGNC 2460 CSNK2B partof FPLX 000104 CK2 -HGNC 2451 CSNK1A1 isa FPLX 000124 CSNK1 -HGNC 20289 CSNK1A1L isa FPLX 000124 CSNK1 -HGNC 2452 CSNK1D isa FPLX 000124 CSNK1 -HGNC 2453 CSNK1E isa FPLX 000124 CSNK1 -HGNC 2454 CSNK1G1 isa FPLX 000124 CSNK1 -HGNC 2455 CSNK1G2 isa FPLX 000124 CSNK1 -HGNC 2456 CSNK1G3 isa FPLX 000124 CSNK1 -HGNC 1874 CFL1 isa FPLX 000107 Cofilin -HGNC 1875 CFL2 isa FPLX 000107 Cofilin -HGNC 15750 DSTN isa FPLX 000107 Cofilin -HGNC 2345 CREB1 isa FPLX 000120 CREB -HGNC 2347 CREB3 isa FPLX 000120 CREB -HGNC 16844 CREB5 isa FPLX 000120 CREB -HGNC 18856 CREB3L1 isa FPLX 000120 CREB -HGNC 23720 CREB3L2 isa FPLX 000120 CREB -HGNC 18855 CREB3L3 isa FPLX 000120 CREB -HGNC 18854 CREB3L4 isa FPLX 000120 CREB -HGNC 2352 CREM isa FPLX 000120 CREB -HGNC 783 ATF1 isa FPLX 000120 CREB -HGNC 784 ATF2 isa FPLX 000120 CREB -HGNC 1577 CCNA1 isa FPLX 000131 Cyclin_A -HGNC 1578 CCNA2 isa FPLX 000131 Cyclin_A -HGNC 1579 CCNB1 isa FPLX 000130 Cyclin -HGNC 1580 CCNB2 isa FPLX 000130 Cyclin -HGNC 18709 CCNB3 isa FPLX 000130 Cyclin -HGNC 1581 CCNC isa FPLX 000130 Cyclin -HGNC 1582 CCND1 isa FPLX 000132 Cyclin_D -HGNC 1583 CCND2 isa FPLX 000132 Cyclin_D -HGNC 1585 CCND3 isa FPLX 000132 Cyclin_D -HGNC 1589 CCNE1 isa FPLX 000133 Cyclin_E -HGNC 1590 CCNE2 isa FPLX 000133 Cyclin_E -HGNC 1591 CCNF isa FPLX 000130 Cyclin -HGNC 1592 CCNG1 isa FPLX 000130 Cyclin -HGNC 1593 CCNG2 isa FPLX 000130 Cyclin -HGNC 1594 CCNH isa FPLX 000130 Cyclin -HGNC 1595 CCNI isa FPLX 000130 Cyclin -HGNC 33869 CCNI2 isa FPLX 000130 Cyclin -HGNC 23434 CCNJ isa FPLX 000130 Cyclin -HGNC 25876 CCNJL isa FPLX 000130 Cyclin -HGNC 1596 CCNK isa FPLX 000130 Cyclin -HGNC 20569 CCNL1 isa FPLX 000130 Cyclin -HGNC 20570 CCNL2 isa FPLX 000130 Cyclin -HGNC 18576 CCNO isa FPLX 000130 Cyclin -HGNC 1599 CCNT1 isa FPLX 000130 Cyclin -HGNC 1600 CCNT2 isa FPLX 000130 Cyclin -HGNC 23354 CCNY isa FPLX 000130 Cyclin -HGNC 26868 CCNYL1 isa FPLX 000130 Cyclin -HGNC 33206 CCNYL3 isa FPLX 000130 Cyclin -FPLX 000131 Cyclin_A isa FPLX 000130 Cyclin -FPLX 000132 Cyclin_D isa FPLX 000130 Cyclin -FPLX 000133 Cyclin_E isa FPLX 000130 Cyclin -HGNC 6871 MAPK1 isa FPLX 000161 ERK -HGNC 6877 MAPK3 isa FPLX 000161 ERK -FPLX 000161 ERK isa FPLX 000283 MAPK -FPLX 000178 F_actin isa FPLX 000009 Actin -HGNC 3688 FGFR1 isa FPLX 000168 FGFR -HGNC 3689 FGFR2 isa FPLX 000168 FGFR -HGNC 3690 FGFR3 isa FPLX 000168 FGFR -HGNC 3691 FGFR4 isa FPLX 000168 FGFR -HGNC 3693 FGFRL1 isa FPLX 000168 FGFR -HGNC 4616 GSK3A isa FPLX 000194 GSK3 -HGNC 4617 GSK3B isa FPLX 000194 GSK3 -HGNC 4852 HDAC1 isa FPLX 000221 HDAC_I -HGNC 4853 HDAC2 isa FPLX 000221 HDAC_I -HGNC 4854 HDAC3 isa FPLX 000221 HDAC_I -HGNC 13315 HDAC8 isa FPLX 000221 HDAC_I -HGNC 14063 HDAC4 isa FPLX 000222 HDAC_II -HGNC 14068 HDAC5 isa FPLX 000222 HDAC_II -HGNC 14067 HDAC7 isa FPLX 000222 HDAC_II -HGNC 14065 HDAC9 isa FPLX 000222 HDAC_II -HGNC 14064 HDAC6 isa FPLX 000222 HDAC_II -HGNC 18128 HDAC10 isa FPLX 000222 HDAC_II -HGNC 14929 SIRT1 isa FPLX 000223 HDAC_III -HGNC 10886 SIRT2 isa FPLX 000223 HDAC_III -HGNC 14931 SIRT3 isa FPLX 000223 HDAC_III -HGNC 14932 SIRT4 isa FPLX 000223 HDAC_III -HGNC 14933 SIRT5 isa FPLX 000223 HDAC_III -HGNC 14934 SIRT6 isa FPLX 000223 HDAC_III -HGNC 14935 SIRT7 isa FPLX 000223 HDAC_III -HGNC 19086 HDAC11 isa FPLX 000224 HDAC_IV -FPLX 000221 HDAC_I isa FPLX 000220 HDAC -FPLX 000222 HDAC_II isa FPLX 000220 HDAC -FPLX 000223 HDAC_III isa FPLX 000220 HDAC -FPLX 000224 HDAC_IV isa FPLX 000220 HDAC -HGNC 4910 HIF1A partof FPLX 000230 HIF1 -HGNC 700 ARNT partof FPLX 000230 HIF1 -HGNC 4910 HIF1A isa FPLX 000231 HIF_alpha -HGNC 3374 EPAS1 isa FPLX 000231 HIF_alpha -HGNC 15825 HIF3A isa FPLX 000231 HIF_alpha -HGNC 700 ARNT isa FPLX 000232 HIF_beta -HGNC 16876 ARNT2 isa FPLX 000232 HIF_beta -HGNC 701 ARNTL isa FPLX 000232 HIF_beta -FPLX 000231 HIF_alpha partof FPLX 000229 HIF -FPLX 000232 HIF_beta partof FPLX 000229 HIF -FPLX 000242 HSP90A isa FPLX 000241 HSP90 -FPLX 000243 HSP90AA isa FPLX 000242 HSP90A -HGNC 5253 HSP90AA1 isa FPLX 000243 HSP90AA -HGNC 5258 HSP90AB1 isa FPLX 000242 HSP90A -HGNC 12028 HSP90B1 isa FPLX 000241 HSP90 -HGNC 16264 TRAP1 isa FPLX 000241 HSP90 -FPLX 000234 Histone_H1 isa FPLX 000233 Histone -FPLX 000235 Histone_H2A isa FPLX 000233 Histone -FPLX 000236 Histone_H2B isa FPLX 000233 Histone -FPLX 000237 Histone_H3 isa FPLX 000233 Histone -FPLX 000238 Histone_H4 isa FPLX 000233 Histone -HGNC 4714 H1F0 isa FPLX 000234 Histone_H1 -HGNC 18463 H1FOO isa FPLX 000234 Histone_H1 -HGNC 4722 H1FX isa FPLX 000234 Histone_H1 -HGNC 4715 HIST1H1A isa FPLX 000234 Histone_H1 -HGNC 4719 HIST1H1B isa FPLX 000234 Histone_H1 -HGNC 4716 HIST1H1C isa FPLX 000234 Histone_H1 -HGNC 4717 HIST1H1D isa FPLX 000234 Histone_H1 -HGNC 4718 HIST1H1E isa FPLX 000234 Histone_H1 -HGNC 4720 HIST1H1T isa FPLX 000234 Histone_H1 -HGNC 24893 H1FNT isa FPLX 000234 Histone_H1 -UP P0C0S8 H2A1_HUMAN isa FPLX 000235 Histone_H2A -HGNC 22516 H2AFB1 isa FPLX 000235 Histone_H2A -UP P0C5Y9 H2AB1_HUMAN isa FPLX 000235 Histone_H2A -HGNC 14456 H2AFJ isa FPLX 000235 Histone_H2A -HGNC 20664 H2AFV isa FPLX 000235 Histone_H2A -HGNC 4739 H2AFX isa FPLX 000235 Histone_H2A -HGNC 4740 H2AFY isa FPLX 000235 Histone_H2A -HGNC 14453 H2AFY2 isa FPLX 000235 Histone_H2A -HGNC 4741 H2AFZ isa FPLX 000235 Histone_H2A -HGNC 18729 HIST1H2AA isa FPLX 000235 Histone_H2A -HGNC 4733 HIST1H2AC isa FPLX 000235 Histone_H2A -HGNC 4729 HIST1H2AD isa FPLX 000235 Histone_H2A -HGNC 13671 HIST1H2AH isa FPLX 000235 Histone_H2A -HGNC 4727 HIST1H2AJ isa FPLX 000235 Histone_H2A -HGNC 20508 HIST2H2AB isa FPLX 000235 Histone_H2A -HGNC 4738 HIST2H2AC isa FPLX 000235 Histone_H2A -HGNC 20507 HIST3H2A isa FPLX 000235 Histone_H2A -UP P04908 H2A1B_HUMAN isa FPLX 000235 Histone_H2A -UP Q6FI13 H2A2A_HUMAN isa FPLX 000235 Histone_H2A -UP P62807 H2B1C_HUMAN isa FPLX 000236 Histone_H2B -HGNC 18730 HIST1H2BA isa FPLX 000236 Histone_H2B -HGNC 4751 HIST1H2BB isa FPLX 000236 Histone_H2B -HGNC 4747 HIST1H2BD isa FPLX 000236 Histone_H2B -HGNC 4755 HIST1H2BH isa FPLX 000236 Histone_H2B -HGNC 4761 HIST1H2BJ isa FPLX 000236 Histone_H2B -HGNC 13954 HIST1H2BK isa FPLX 000236 Histone_H2B -HGNC 4748 HIST1H2BL isa FPLX 000236 Histone_H2B -HGNC 4750 HIST1H2BM isa FPLX 000236 Histone_H2B -HGNC 4749 HIST1H2BN isa FPLX 000236 Histone_H2B -HGNC 4758 HIST1H2BO isa FPLX 000236 Histone_H2B -HGNC 20516 HIST2H2BC isa FPLX 000236 Histone_H2B -HGNC 20517 HIST2H2BD isa FPLX 000236 Histone_H2B -HGNC 4760 HIST2H2BE isa FPLX 000236 Histone_H2B -HGNC 24700 HIST2H2BF isa FPLX 000236 Histone_H2B -HGNC 20514 HIST3H2BB isa FPLX 000236 Histone_H2B -HGNC 4762 H2BFS isa FPLX 000236 Histone_H2B -HGNC 27867 H2BFM isa FPLX 000236 Histone_H2B -HGNC 27252 H2BFWT isa FPLX 000236 Histone_H2B -UP P68431 H31_HUMAN isa FPLX 000237 Histone_H3 -UP Q71DI3 H32_HUMAN isa FPLX 000237 Histone_H3 -HGNC 4778 HIST3H3 isa FPLX 000237 Histone_H3 -UP P84243 H33_HUMAN isa FPLX 000237 Histone_H3 -HGNC 33164 H3F3C isa FPLX 000237 Histone_H3 -UP P62805 H4_HUMAN isa FPLX 000238 Histone_H4 -HGNC 4792 HIST1H4G isa FPLX 000238 Histone_H4 -HGNC 11362 STAT1 isa FPLX 000453 STAT -HGNC 11363 STAT2 isa FPLX 000453 STAT -HGNC 11364 STAT3 isa FPLX 000453 STAT -HGNC 11365 STAT4 isa FPLX 000453 STAT -HGNC 11366 STAT5A isa FPLX 000454 STAT5 -HGNC 11367 STAT5B isa FPLX 000454 STAT5 -HGNC 11368 STAT6 isa FPLX 000453 STAT -FPLX 000454 STAT5 isa FPLX 000453 STAT -HGNC 8799 PDGFA isa FPLX 000342 PDGF -HGNC 8800 PDGFB isa FPLX 000342 PDGF -HGNC 8801 PDGFC isa FPLX 000342 PDGF -HGNC 30620 PDGFD isa FPLX 000342 PDGF -HGNC 8799 PDGFA partof FPLX 000347 PDGF_AA -HGNC 8799 PDGFA partof FPLX 000348 PDGF_AB -HGNC 8800 PDGFB partof FPLX 000348 PDGF_AB -HGNC 8800 PDGFB partof FPLX 000349 PDGF_BB -HGNC 8801 PDGFC partof FPLX 000350 PDGF_CC -HGNC 30620 PDGFD partof FPLX 000351 PDGF_DD -HGNC 8803 PDGFRA isa FPLX 000343 PDGFR -HGNC 8804 PDGFRB isa FPLX 000343 PDGFR -HGNC 8803 PDGFRA partof FPLX 000344 PDGFR_AA -HGNC 8803 PDGFRA partof FPLX 000345 PDGFR_AB -HGNC 8804 PDGFRB partof FPLX 000345 PDGFR_AB -HGNC 8804 PDGFRB partof FPLX 000346 PDGFR_BB -HGNC 4389 GNAO1 isa FPLX 000213 G_i_alpha -HGNC 4384 GNAI1 isa FPLX 000213 G_i_alpha -HGNC 4385 GNAI2 isa FPLX 000213 G_i_alpha -HGNC 4387 GNAI3 isa FPLX 000213 G_i_alpha -HGNC 4393 GNAT1 isa FPLX 000213 G_i_alpha -HGNC 4394 GNAT2 isa FPLX 000213 G_i_alpha -HGNC 22800 GNAT3 isa FPLX 000213 G_i_alpha -HGNC 4395 GNAZ isa FPLX 000213 G_i_alpha -HGNC 4392 GNAS isa FPLX 000218 G_s_alpha -HGNC 4388 GNAL isa FPLX 000218 G_s_alpha -HGNC 4390 GNAQ isa FPLX 000216 G_q_alpha -HGNC 4379 GNA11 isa FPLX 000216 G_q_alpha -HGNC 4382 GNA14 isa FPLX 000216 G_q_alpha -HGNC 4383 GNA15 isa FPLX 000216 G_q_alpha -HGNC 4380 GNA12 isa FPLX 000208 G_12_alpha -HGNC 4381 GNA13 isa FPLX 000208 G_12_alpha -FPLX 000213 G_i_alpha isa FPLX 000209 G_alpha -FPLX 000218 G_s_alpha isa FPLX 000209 G_alpha -FPLX 000216 G_q_alpha isa FPLX 000209 G_alpha -FPLX 000208 G_12_alpha isa FPLX 000209 G_alpha -FPLX 000213 G_i_alpha partof FPLX 000212 G_i -FPLX 000218 G_s_alpha partof FPLX 000217 G_s -FPLX 000216 G_q_alpha partof FPLX 000215 G_q -FPLX 000208 G_12_alpha partof FPLX 000207 G_12 -FPLX 000212 G_i isa FPLX 000214 G_protein -FPLX 000217 G_s isa FPLX 000214 G_protein -FPLX 000215 G_q isa FPLX 000214 G_protein -FPLX 000207 G_12 isa FPLX 000214 G_protein -HGNC 19989 ANAPC2 partof FPLX 000050 APC_C -HGNC 14452 ANAPC11 partof FPLX 000050 APC_C -HGNC 19988 ANAPC1 partof FPLX 000050 APC_C -HGNC 1720 CDC16 partof FPLX 000050 APC_C -HGNC 1728 CDC27 partof FPLX 000050 APC_C -HGNC 1724 CDC23 partof FPLX 000050 APC_C -HGNC 15713 ANAPC5 partof FPLX 000050 APC_C -HGNC 24077 ANAPC10 partof FPLX 000050 APC_C -HGNC 24531 ANAPC15 partof FPLX 000050 APC_C -HGNC 24540 ANAPC13 partof FPLX 000050 APC_C -HGNC 17839 CDC26 partof FPLX 000050 APC_C -HGNC 26976 ANAPC16 partof FPLX 000050 APC_C -HGNC 17380 ANAPC7 partof FPLX 000050 APC_C -HGNC 19990 ANAPC4 partof FPLX 000050 APC_C -HGNC 3236 EGFR isa FPLX 000160 ERBB -HGNC 3430 ERBB2 isa FPLX 000160 ERBB -HGNC 3431 ERBB3 isa FPLX 000160 ERBB -HGNC 3432 ERBB4 isa FPLX 000160 ERBB -HGNC 3296 EIF4G1 isa FPLX 000155 EIF4G -HGNC 3297 EIF4G2 isa FPLX 000155 EIF4G -HGNC 3298 EIF4G3 isa FPLX 000155 EIF4G -HGNC 7775 NFATC1 isa FPLX 000309 NFAT -HGNC 7776 NFATC2 isa FPLX 000309 NFAT -HGNC 7777 NFATC3 isa FPLX 000309 NFAT -HGNC 7778 NFATC4 isa FPLX 000309 NFAT -HGNC 7774 NFAT5 isa FPLX 000309 NFAT -HGNC 4706 GYS1 isa FPLX 000206 GYS -HGNC 4707 GYS2 isa FPLX 000206 GYS -HGNC 20766 TUBA1A isa FPLX 000483 TUBA -HGNC 18809 TUBA1B isa FPLX 000483 TUBA -HGNC 20768 TUBA1C isa FPLX 000483 TUBA -HGNC 12408 TUBA3C isa FPLX 000483 TUBA -HGNC 24071 TUBA3D isa FPLX 000483 TUBA -HGNC 20765 TUBA3E isa FPLX 000483 TUBA -HGNC 12407 TUBA4A isa FPLX 000483 TUBA -HGNC 12410 TUBA8 isa FPLX 000483 TUBA -HGNC 23534 TUBAL3 isa FPLX 000483 TUBA -HGNC 20778 TUBB isa FPLX 000484 TUBB -HGNC 16257 TUBB1 isa FPLX 000484 TUBB -HGNC 12412 TUBB2A isa FPLX 000484 TUBB -HGNC 30829 TUBB2B isa FPLX 000484 TUBB -HGNC 20772 TUBB3 isa FPLX 000484 TUBB -HGNC 20774 TUBB4A isa FPLX 000484 TUBB -HGNC 20771 TUBB4B isa FPLX 000484 TUBB -HGNC 20776 TUBB6 isa FPLX 000484 TUBB -HGNC 12417 TUBG1 isa FPLX 000485 TUBG -HGNC 12419 TUBG2 isa FPLX 000485 TUBG -FPLX 000483 TUBA isa FPLX 000486 Tubulin -FPLX 000484 TUBB isa FPLX 000486 Tubulin -FPLX 000485 TUBG isa FPLX 000486 Tubulin -HGNC 16811 TUBD1 isa FPLX 000486 Tubulin -HGNC 20775 TUBE1 isa FPLX 000486 Tubulin -HGNC 6190 JAK1 isa FPLX 000266 JAK -HGNC 6192 JAK2 isa FPLX 000266 JAK -HGNC 6193 JAK3 isa FPLX 000266 JAK -HGNC 12440 TYK2 isa FPLX 000266 JAK -HGNC 1706 CD8A isa FPLX 000090 CD8 -HGNC 1707 CD8B isa FPLX 000090 CD8 -HGNC 6535 LDHA isa FPLX 000275 LDH -HGNC 6541 LDHB isa FPLX 000275 LDH -HGNC 6544 LDHC isa FPLX 000275 LDH -HGNC 10430 RPS6KA1 isa FPLX 000329 P90RSK -HGNC 10431 RPS6KA2 isa FPLX 000329 P90RSK -HGNC 10432 RPS6KA3 isa FPLX 000329 P90RSK -HGNC 10433 RPS6KA4 isa FPLX 000329 P90RSK -HGNC 10434 RPS6KA5 isa FPLX 000329 P90RSK -HGNC 10435 RPS6KA6 isa FPLX 000329 P90RSK -HGNC 10436 RPS6KB1 isa FPLX 000328 P70S6K -HGNC 10437 RPS6KB2 isa FPLX 000328 P70S6K -FPLX 000329 P90RSK isa FPLX 000422 RSK -FPLX 000328 P70S6K isa FPLX 000422 RSK -HGNC 9955 RELA isa FPLX 000313 NFkappaB_2 -HGNC 9956 RELB isa FPLX 000313 NFkappaB_2 -HGNC 9954 REL isa FPLX 000313 NFkappaB_2 -HGNC 7794 NFKB1 isa FPLX 000312 NFkappaB_1 -HGNC 7795 NFKB2 isa FPLX 000312 NFkappaB_1 -FPLX 000312 NFkappaB_1 partof FPLX 000311 NFkappaB -FPLX 000313 NFkappaB_2 partof FPLX 000311 NFkappaB -HGNC 11847 TLR1 isa FPLX 000472 TLR -HGNC 11848 TLR2 isa FPLX 000472 TLR -HGNC 11849 TLR3 isa FPLX 000472 TLR -HGNC 11850 TLR4 isa FPLX 000472 TLR -HGNC 11851 TLR5 isa FPLX 000472 TLR -HGNC 16711 TLR6 isa FPLX 000472 TLR -HGNC 15631 TLR7 isa FPLX 000472 TLR -HGNC 15632 TLR8 isa FPLX 000472 TLR -HGNC 15633 TLR9 isa FPLX 000472 TLR -HGNC 15634 TLR10 isa FPLX 000472 TLR -HGNC 11110 ARID1A partof FPLX 000457 SWI_SNF -HGNC 18040 ARID1B partof FPLX 000457 SWI_SNF -HGNC 11097 SMARCA1 partof FPLX 000457 SWI_SNF -HGNC 11098 SMARCA2 partof FPLX 000457 SWI_SNF -HGNC 11100 SMARCA4 partof FPLX 000457 SWI_SNF -HGNC 11101 SMARCA5 partof FPLX 000457 SWI_SNF -HGNC 11103 SMARCB1 partof FPLX 000457 SWI_SNF -HGNC 11104 SMARCC1 partof FPLX 000457 SWI_SNF -HGNC 11105 SMARCC2 partof FPLX 000457 SWI_SNF -HGNC 11106 SMARCD1 partof FPLX 000457 SWI_SNF -HGNC 11107 SMARCD2 partof FPLX 000457 SWI_SNF -HGNC 11108 SMARCD3 partof FPLX 000457 SWI_SNF -HGNC 11109 SMARCE1 partof FPLX 000457 SWI_SNF -HGNC 24124 ACTL6A partof FPLX 000457 SWI_SNF -HGNC 160 ACTL6B partof FPLX 000457 SWI_SNF -HGNC 11099 HLTF partof FPLX 000457 SWI_SNF -HGNC 1067 BMP1 isa FPLX 000067 BMP -HGNC 1069 BMP2 isa FPLX 000067 BMP -HGNC 1070 BMP3 isa FPLX 000067 BMP -HGNC 1071 BMP4 isa FPLX 000067 BMP -HGNC 1072 BMP5 isa FPLX 000067 BMP -HGNC 1073 BMP6 isa FPLX 000067 BMP -HGNC 1074 BMP7 isa FPLX 000067 BMP -HGNC 21650 BMP8A isa FPLX 000067 BMP -HGNC 1075 BMP8B isa FPLX 000067 BMP -HGNC 20869 BMP10 isa FPLX 000067 BMP -HGNC 1068 BMP15 isa FPLX 000067 BMP -HGNC 5969 IL12A isa FPLX 000253 IL12 -HGNC 5970 IL12B isa FPLX 000253 IL12 -HGNC 5991 IL1A isa FPLX 000252 IL1 -HGNC 5992 IL1B isa FPLX 000252 IL1 -HGNC 11179 SOD1 isa FPLX 000447 SOD -HGNC 11180 SOD2 isa FPLX 000447 SOD -HGNC 11181 SOD3 isa FPLX 000447 SOD -HGNC 12362 TSC1 isa FPLX 000482 TSC -HGNC 12363 TSC2 isa FPLX 000482 TSC -HGNC 3819 FOXO1 isa FPLX 000174 FOXO -HGNC 3821 FOXO3 isa FPLX 000174 FOXO -HGNC 7139 FOXO4 isa FPLX 000174 FOXO -HGNC 24814 FOXO6 isa FPLX 000174 FOXO -HGNC 7155 MMP1 isa FPLX 000291 MMP -HGNC 7166 MMP2 isa FPLX 000291 MMP -HGNC 7173 MMP3 isa FPLX 000291 MMP -HGNC 7174 MMP7 isa FPLX 000291 MMP -HGNC 7175 MMP8 isa FPLX 000291 MMP -HGNC 7176 MMP9 isa FPLX 000291 MMP -HGNC 7156 MMP10 isa FPLX 000291 MMP -HGNC 7157 MMP11 isa FPLX 000291 MMP -HGNC 7158 MMP12 isa FPLX 000291 MMP -HGNC 7159 MMP13 isa FPLX 000291 MMP -HGNC 7160 MMP14 isa FPLX 000291 MMP -HGNC 7161 MMP15 isa FPLX 000291 MMP -HGNC 7162 MMP16 isa FPLX 000291 MMP -HGNC 7163 MMP17 isa FPLX 000291 MMP -HGNC 7165 MMP19 isa FPLX 000291 MMP -HGNC 7167 MMP20 isa FPLX 000291 MMP -HGNC 14357 MMP21 isa FPLX 000291 MMP -HGNC 7171 MMP23B isa FPLX 000291 MMP -HGNC 7172 MMP24 isa FPLX 000291 MMP -HGNC 14246 MMP25 isa FPLX 000291 MMP -HGNC 14249 MMP26 isa FPLX 000291 MMP -HGNC 14250 MMP27 isa FPLX 000291 MMP -HGNC 14366 MMP28 isa FPLX 000291 MMP -HGNC 84 ACACA partof FPLX 000005 ACC -HGNC 85 ACACB partof FPLX 000005 ACC -HGNC 6838 MAP1LC3A isa FPLX 000280 MAP1LC3 -HGNC 13352 MAP1LC3B isa FPLX 000280 MAP1LC3 -HGNC 34390 MAP1LC3B2 isa FPLX 000280 MAP1LC3 -HGNC 13353 MAP1LC3C isa FPLX 000280 MAP1LC3 -HGNC 5417 IFNA1 isa FPLX 000246 IFNA -HGNC 5423 IFNA2 isa FPLX 000246 IFNA -HGNC 5425 IFNA4 isa FPLX 000246 IFNA -HGNC 5426 IFNA5 isa FPLX 000246 IFNA -HGNC 5427 IFNA6 isa FPLX 000246 IFNA -HGNC 5428 IFNA7 isa FPLX 000246 IFNA -HGNC 5429 IFNA8 isa FPLX 000246 IFNA -HGNC 5418 IFNA10 isa FPLX 000246 IFNA -HGNC 5419 IFNA13 isa FPLX 000246 IFNA -HGNC 5420 IFNA14 isa FPLX 000246 IFNA -HGNC 5421 IFNA16 isa FPLX 000246 IFNA -HGNC 5422 IFNA17 isa FPLX 000246 IFNA -HGNC 5424 IFNA21 isa FPLX 000246 IFNA -HGNC 5434 IFNB1 isa FPLX 000247 IFNB -FPLX 000246 IFNA isa FPLX 000262 Interferon -FPLX 000247 IFNB isa FPLX 000262 Interferon -HGNC 21714 IFNK isa FPLX 000262 Interferon -HGNC 5448 IFNW1 isa FPLX 000262 Interferon -HGNC 11916 TNFRSF1A isa FPLX 000137 Death_receptor -HGNC 11917 TNFRSF1B isa FPLX 000137 Death_receptor -HGNC 11904 TNFRSF10A isa FPLX 000137 Death_receptor -HGNC 11905 TNFRSF10B isa FPLX 000137 Death_receptor -HGNC 11906 TNFRSF10C isa FPLX 000137 Death_receptor -HGNC 11907 TNFRSF10D isa FPLX 000137 Death_receptor -HGNC 11920 FAS isa FPLX 000137 Death_receptor -HGNC 11916 TNFRSF1A isa FPLX 000475 TNFRSF -HGNC 11917 TNFRSF1B isa FPLX 000475 TNFRSF -HGNC 11918 TNFRSF4 isa FPLX 000475 TNFRSF -HGNC 11923 TNFRSF8 isa FPLX 000475 TNFRSF -HGNC 11924 TNFRSF9 isa FPLX 000475 TNFRSF -HGNC 11904 TNFRSF10A isa FPLX 000475 TNFRSF -HGNC 11905 TNFRSF10B isa FPLX 000475 TNFRSF -HGNC 11906 TNFRSF10C isa FPLX 000475 TNFRSF -HGNC 11907 TNFRSF10D isa FPLX 000475 TNFRSF -HGNC 11908 TNFRSF11A isa FPLX 000475 TNFRSF -HGNC 11909 TNFRSF11B isa FPLX 000475 TNFRSF -HGNC 18152 TNFRSF12A isa FPLX 000475 TNFRSF -HGNC 18153 TNFRSF13B isa FPLX 000475 TNFRSF -HGNC 17755 TNFRSF13C isa FPLX 000475 TNFRSF -HGNC 11912 TNFRSF14 isa FPLX 000475 TNFRSF -HGNC 11913 TNFRSF17 isa FPLX 000475 TNFRSF -HGNC 11914 TNFRSF18 isa FPLX 000475 TNFRSF -HGNC 11915 TNFRSF19 isa FPLX 000475 TNFRSF -HGNC 13469 TNFRSF21 isa FPLX 000475 TNFRSF -HGNC 11910 TNFRSF25 isa FPLX 000475 TNFRSF -HGNC 3665 FGF1 isa FPLX 000167 FGF -HGNC 3676 FGF2 isa FPLX 000167 FGF -HGNC 3681 FGF3 isa FPLX 000167 FGF -HGNC 3682 FGF4 isa FPLX 000167 FGF -HGNC 3683 FGF5 isa FPLX 000167 FGF -HGNC 3684 FGF6 isa FPLX 000167 FGF -HGNC 3685 FGF7 isa FPLX 000167 FGF -HGNC 3686 FGF8 isa FPLX 000167 FGF -HGNC 3687 FGF9 isa FPLX 000167 FGF -HGNC 3666 FGF10 isa FPLX 000167 FGF -HGNC 3667 FGF11 isa FPLX 000167 FGF -HGNC 3668 FGF12 isa FPLX 000167 FGF -HGNC 3670 FGF13 isa FPLX 000167 FGF -HGNC 3671 FGF14 isa FPLX 000167 FGF -HGNC 3672 FGF16 isa FPLX 000167 FGF -HGNC 3673 FGF17 isa FPLX 000167 FGF -HGNC 3674 FGF18 isa FPLX 000167 FGF -HGNC 3675 FGF19 isa FPLX 000167 FGF -HGNC 3677 FGF20 isa FPLX 000167 FGF -HGNC 3678 FGF21 isa FPLX 000167 FGF -HGNC 3679 FGF22 isa FPLX 000167 FGF -HGNC 3680 FGF23 isa FPLX 000167 FGF -HGNC 12774 WNT1 isa FPLX 000497 Wnt -HGNC 12780 WNT2 isa FPLX 000497 Wnt -HGNC 12781 WNT2B isa FPLX 000497 Wnt -HGNC 12782 WNT3 isa FPLX 000497 Wnt -HGNC 15983 WNT3A isa FPLX 000497 Wnt -HGNC 12783 WNT4 isa FPLX 000497 Wnt -HGNC 12784 WNT5A isa FPLX 000497 Wnt -HGNC 16265 WNT5B isa FPLX 000497 Wnt -HGNC 12785 WNT6 isa FPLX 000497 Wnt -HGNC 12786 WNT7A isa FPLX 000497 Wnt -HGNC 12787 WNT7B isa FPLX 000497 Wnt -HGNC 12788 WNT8A isa FPLX 000497 Wnt -HGNC 12789 WNT8B isa FPLX 000497 Wnt -HGNC 12778 WNT9A isa FPLX 000497 Wnt -HGNC 12779 WNT9B isa FPLX 000497 Wnt -HGNC 13829 WNT10A isa FPLX 000497 Wnt -HGNC 12775 WNT10B isa FPLX 000497 Wnt -HGNC 12776 WNT11 isa FPLX 000497 Wnt -HGNC 16267 WNT16 isa FPLX 000497 Wnt -HGNC 646 ARAF isa FPLX 000399 RAF -HGNC 1097 BRAF isa FPLX 000399 RAF -HGNC 9829 RAF1 isa FPLX 000399 RAF -FPLX 000399 RAF isa FPLX 000282 MAP3K -HGNC 6848 MAP3K1 isa FPLX 000282 MAP3K -HGNC 6854 MAP3K2 isa FPLX 000282 MAP3K -HGNC 6855 MAP3K3 isa FPLX 000282 MAP3K -HGNC 6856 MAP3K4 isa FPLX 000282 MAP3K -HGNC 6857 MAP3K5 isa FPLX 000282 MAP3K -HGNC 6858 MAP3K6 isa FPLX 000282 MAP3K -HGNC 6859 MAP3K7 isa FPLX 000282 MAP3K -HGNC 6860 MAP3K8 isa FPLX 000282 MAP3K -HGNC 6861 MAP3K9 isa FPLX 000282 MAP3K -HGNC 6849 MAP3K10 isa FPLX 000282 MAP3K -HGNC 6850 MAP3K11 isa FPLX 000282 MAP3K -HGNC 6851 MAP3K12 isa FPLX 000282 MAP3K -HGNC 6852 MAP3K13 isa FPLX 000282 MAP3K -HGNC 6853 MAP3K14 isa FPLX 000282 MAP3K -HGNC 31689 MAP3K15 isa FPLX 000282 MAP3K -FPLX 000458 TAOK isa FPLX 000282 MAP3K -HGNC 29259 TAOK1 isa FPLX 000458 TAOK -HGNC 16835 TAOK2 isa FPLX 000458 TAOK -HGNC 18133 TAOK3 isa FPLX 000458 TAOK -HGNC 26249 MAP3K19 isa FPLX 000282 MAP3K -HGNC 17797 MAP3K20 isa FPLX 000282 MAP3K -HGNC 29798 MAP3K21 isa FPLX 000282 MAP3K -HGNC 1100 BRCA1 isa FPLX 000071 BRCA -HGNC 1101 BRCA2 isa FPLX 000071 BRCA -HGNC 19700 CNKSR1 isa FPLX 000106 CNKSR -HGNC 19701 CNKSR2 isa FPLX 000106 CNKSR -HGNC 3064 DUSP1 isa FPLX 000144 DUSP -HGNC 3068 DUSP2 isa FPLX 000144 DUSP -HGNC 3069 DUSP3 isa FPLX 000144 DUSP -HGNC 3070 DUSP4 isa FPLX 000144 DUSP -HGNC 3071 DUSP5 isa FPLX 000144 DUSP -HGNC 3072 DUSP6 isa FPLX 000144 DUSP -HGNC 3488 ETS1 isa FPLX 000163 ETS -HGNC 3489 ETS2 isa FPLX 000163 ETS -HGNC 30380 EXOC1 partof FPLX 000164 EXOC -HGNC 24968 EXOC2 partof FPLX 000164 EXOC -HGNC 30378 EXOC3 partof FPLX 000164 EXOC -HGNC 30389 EXOC4 partof FPLX 000164 EXOC -HGNC 10696 EXOC5 partof FPLX 000164 EXOC -HGNC 23196 EXOC6 partof FPLX 000164 EXOC -HGNC 23214 EXOC7 partof FPLX 000164 EXOC -HGNC 24659 EXOC8 partof FPLX 000164 EXOC -HGNC 3582 FANCA isa FPLX 000166 FANC -HGNC 3583 FANCB isa FPLX 000166 FANC -HGNC 3584 FANCC isa FPLX 000166 FANC -HGNC 1101 BRCA2 isa FPLX 000166 FANC -HGNC 3585 FANCD2 isa FPLX 000166 FANC -HGNC 3586 FANCE isa FPLX 000166 FANC -HGNC 3587 FANCF isa FPLX 000166 FANC -HGNC 3588 FANCG isa FPLX 000166 FANC -HGNC 25568 FANCI isa FPLX 000166 FANC -HGNC 20473 BRIP1 isa FPLX 000166 FANC -HGNC 20748 FANCL isa FPLX 000166 FANC -HGNC 23168 FANCM isa FPLX 000166 FANC -HGNC 26144 PALB2 isa FPLX 000166 FANC -HGNC 9820 RAD51C isa FPLX 000166 FANC -HGNC 23845 SLX4 isa FPLX 000166 FANC -HGNC 3436 ERCC4 isa FPLX 000166 FANC -HGNC 9817 RAD51 isa FPLX 000166 FANC -HGNC 1100 BRCA1 isa FPLX 000166 FANC -HGNC 25009 UBE2T isa FPLX 000166 FANC -HGNC 12829 XRCC2 isa FPLX 000166 FANC -HGNC 3782 FNTA partof FPLX 000172 FNT -HGNC 3785 FNTB partof FPLX 000172 FNT -HGNC 6407 KRAS isa FPLX 000404 RAS -HGNC 5173 HRAS isa FPLX 000404 RAS -HGNC 7989 NRAS isa FPLX 000404 RAS -HGNC 6465 KSR1 isa FPLX 000272 KSR -HGNC 18610 KSR2 isa FPLX 000272 KSR -HGNC 6840 MAP2K1 isa FPLX 000286 MEK -HGNC 6842 MAP2K2 isa FPLX 000286 MEK -FPLX 000286 MEK isa FPLX 000281 MAP2K -HGNC 6843 MAP2K3 isa FPLX 000281 MAP2K -HGNC 6844 MAP2K4 isa FPLX 000281 MAP2K -HGNC 6845 MAP2K5 isa FPLX 000281 MAP2K -HGNC 6846 MAP2K6 isa FPLX 000281 MAP2K -HGNC 6847 MAP2K7 isa FPLX 000281 MAP2K -HGNC 6944 MCM2 isa FPLX 000284 MCM -HGNC 6945 MCM3 isa FPLX 000284 MCM -HGNC 6947 MCM4 isa FPLX 000284 MCM -HGNC 6948 MCM5 isa FPLX 000284 MCM -HGNC 6949 MCM6 isa FPLX 000284 MCM -HGNC 6950 MCM7 isa FPLX 000284 MCM -HGNC 16147 MCM8 isa FPLX 000284 MCM -HGNC 21484 MCM9 isa FPLX 000284 MCM -HGNC 26368 MCMDC2 isa FPLX 000284 MCM -HGNC 8590 PAK1 isa FPLX 000330 PAK -HGNC 8591 PAK2 isa FPLX 000330 PAK -HGNC 8592 PAK3 isa FPLX 000330 PAK -HGNC 16059 PAK4 isa FPLX 000330 PAK -HGNC 15916 PAK5 isa FPLX 000330 PAK -HGNC 16061 PAK6 isa FPLX 000330 PAK -HGNC 9801 RAC1 isa FPLX 000398 RAC -HGNC 9802 RAC2 isa FPLX 000398 RAC -HGNC 9803 RAC3 isa FPLX 000398 RAC -HGNC 672 RHOG isa FPLX 000398 RAC -HGNC 9839 RALA isa FPLX 000400 RAL -HGNC 9840 RALB isa FPLX 000400 RAL -HGNC 4568 RAPGEF1 isa FPLX 000402 RAPGEF -HGNC 16854 RAPGEF2 isa FPLX 000402 RAPGEF -HGNC 9871 RASA1 isa FPLX 000405 RASA -HGNC 9872 RASA2 isa FPLX 000405 RASA -HGNC 20331 RASA3 isa FPLX 000405 RASA -HGNC 9873 RASAL1 isa FPLX 000406 RASAL -HGNC 9874 RASAL2 isa FPLX 000406 RASAL -HGNC 26129 RASAL3 isa FPLX 000406 RASAL -HGNC 9875 RASGRF1 isa FPLX 000408 RASGRF -HGNC 9876 RASGRF2 isa FPLX 000408 RASGRF -HGNC 9878 RASGRP1 isa FPLX 000409 RASGRP -HGNC 9879 RASGRP2 isa FPLX 000409 RASGRP -HGNC 14545 RASGRP3 isa FPLX 000409 RASGRP -HGNC 18958 RASGRP4 isa FPLX 000409 RASGRP -HGNC 9882 RASSF1 isa FPLX 000410 RASSF -HGNC 9883 RASSF2 isa FPLX 000410 RASSF -HGNC 14271 RASSF3 isa FPLX 000410 RASSF -HGNC 20793 RASSF4 isa FPLX 000410 RASSF -HGNC 17609 RASSF5 isa FPLX 000410 RASSF -HGNC 20796 RASSF6 isa FPLX 000410 RASSF -HGNC 1166 RASSF7 isa FPLX 000410 RASSF -HGNC 13232 RASSF8 isa FPLX 000410 RASSF -HGNC 15739 RASSF9 isa FPLX 000410 RASSF -HGNC 33984 RASSF10 isa FPLX 000410 RASSF -HGNC 30281 RGL1 isa FPLX 000413 RGL -HGNC 9769 RGL2 isa FPLX 000413 RGL -HGNC 30282 RGL3 isa FPLX 000413 RGL -HGNC 667 RHOA isa FPLX 000414 RHO -HGNC 668 RHOB isa FPLX 000414 RHO -HGNC 669 RHOC isa FPLX 000414 RHO -HGNC 10251 ROCK1 isa FPLX 000419 ROCK -HGNC 10252 ROCK2 isa FPLX 000419 ROCK -HGNC 10840 SHC1 isa FPLX 000432 SHC -HGNC 29869 SHC2 isa FPLX 000432 SHC -HGNC 18181 SHC3 isa FPLX 000432 SHC -HGNC 16743 SHC4 isa FPLX 000432 SHC -HGNC 11187 SOS1 isa FPLX 000448 SOS -HGNC 11188 SOS2 isa FPLX 000448 SOS -HGNC 11269 SPRY1 isa FPLX 000450 SPRY -HGNC 11270 SPRY2 isa FPLX 000450 SPRY -HGNC 11271 SPRY3 isa FPLX 000450 SPRY -HGNC 15533 SPRY4 isa FPLX 000450 SPRY -HGNC 11749 TFDP1 isa FPLX 000464 TFDP -HGNC 11751 TFDP2 isa FPLX 000464 TFDP -HGNC 11805 TIAM1 isa FPLX 000470 TIAM -HGNC 11806 TIAM2 isa FPLX 000470 TIAM -HGNC 20249 SPRED1 isa FPLX 000449 SPRED -HGNC 17722 SPRED2 isa FPLX 000449 SPRED -HGNC 31041 SPRED3 isa FPLX 000449 SPRED -HGNC 1885 CGA partof FPLX 000219 hCG -HGNC 1886 CGB3 partof FPLX 000219 hCG -HGNC 10513 SAA1 isa FPLX 000428 SAA -HGNC 10514 SAA2 isa FPLX 000428 SAA -HGNC 10516 SAA4 isa FPLX 000428 SAA -HGNC 6873 MAPK11 isa FPLX 000326 p38 -HGNC 6874 MAPK12 isa FPLX 000326 p38 -HGNC 6875 MAPK13 isa FPLX 000326 p38 -HGNC 6876 MAPK14 isa FPLX 000326 p38 -FPLX 000326 p38 isa FPLX 000283 MAPK -HGNC 10773 SFN isa FPLX 000323 p14_3_3 -HGNC 12849 YWHAB isa FPLX 000323 p14_3_3 -HGNC 12851 YWHAE isa FPLX 000323 p14_3_3 -HGNC 12852 YWHAG isa FPLX 000323 p14_3_3 -HGNC 12853 YWHAH isa FPLX 000323 p14_3_3 -HGNC 12854 YWHAQ isa FPLX 000323 p14_3_3 -HGNC 12855 YWHAZ isa FPLX 000323 p14_3_3 -HGNC 59 ABCC8 isa FPLX 000456 Sulfonylurea_receptor -HGNC 60 ABCC9 isa FPLX 000456 Sulfonylurea_receptor -HGNC 87 ACAD8 isa FPLX 000004 ACAD -HGNC 21497 ACAD9 isa FPLX 000004 ACAD -HGNC 88 ACADL isa FPLX 000004 ACAD -HGNC 89 ACADM isa FPLX 000004 ACAD -HGNC 90 ACADS isa FPLX 000004 ACAD -HGNC 92 ACADVL isa FPLX 000004 ACAD -HGNC 21597 ACAD10 isa FPLX 000004 ACAD -HGNC 30211 ACAD11 isa FPLX 000004 ACAD -HGNC 91 ACADSB isa FPLX 000004 ACAD -HGNC 4189 GCDH isa FPLX 000004 ACAD -HGNC 6186 IVD isa FPLX 000004 ACAD -HGNC 10996 SLC27A2 isa FPLX 000006 Acetyl_CoA_synthetase -HGNC 3569 ACSL1 isa FPLX 000006 Acetyl_CoA_synthetase -HGNC 3570 ACSL3 isa FPLX 000006 Acetyl_CoA_synthetase -HGNC 3571 ACSL4 isa FPLX 000006 Acetyl_CoA_synthetase -HGNC 16526 ACSL5 isa FPLX 000006 Acetyl_CoA_synthetase -HGNC 16496 ACSL6 isa FPLX 000006 Acetyl_CoA_synthetase -HGNC 119 ACOX1 isa FPLX 000007 ACOX -HGNC 120 ACOX2 isa FPLX 000007 ACOX -HGNC 121 ACOX3 isa FPLX 000007 ACOX -HGNC 25621 ACOXL isa FPLX 000007 ACOX -HGNC 3569 ACSL1 isa FPLX 000008 ACSL -HGNC 3570 ACSL3 isa FPLX 000008 ACSL -HGNC 3571 ACSL4 isa FPLX 000008 ACSL -HGNC 16526 ACSL5 isa FPLX 000008 ACSL -HGNC 16496 ACSL6 isa FPLX 000008 ACSL -HGNC 163 ACTN1 isa FPLX 000014 ACTN -HGNC 164 ACTN2 isa FPLX 000014 ACTN -HGNC 165 ACTN3 isa FPLX 000014 ACTN -HGNC 166 ACTN4 isa FPLX 000014 ACTN -HGNC 232 ADCY1 isa FPLX 000017 ADCY -HGNC 233 ADCY2 isa FPLX 000017 ADCY -HGNC 234 ADCY3 isa FPLX 000017 ADCY -HGNC 235 ADCY4 isa FPLX 000017 ADCY -HGNC 236 ADCY5 isa FPLX 000017 ADCY -HGNC 237 ADCY6 isa FPLX 000017 ADCY -HGNC 238 ADCY7 isa FPLX 000017 ADCY -HGNC 239 ADCY8 isa FPLX 000017 ADCY -HGNC 240 ADCY9 isa FPLX 000017 ADCY -HGNC 21285 ADCY10 isa FPLX 000017 ADCY -HGNC 249 ADH1A isa FPLX 000018 ADH -HGNC 250 ADH1B isa FPLX 000018 ADH -HGNC 251 ADH1C isa FPLX 000018 ADH -HGNC 252 ADH4 isa FPLX 000018 ADH -HGNC 253 ADH5 isa FPLX 000018 ADH -HGNC 255 ADH6 isa FPLX 000018 ADH -HGNC 256 ADH7 isa FPLX 000018 ADH -HGNC 16354 ADHFE1 isa FPLX 000018 ADH -HGNC 277 ADRA1A isa FPLX 000019 ADRA -HGNC 278 ADRA1B isa FPLX 000019 ADRA -HGNC 280 ADRA1D isa FPLX 000019 ADRA -HGNC 281 ADRA2A isa FPLX 000019 ADRA -HGNC 282 ADRA2B isa FPLX 000019 ADRA -HGNC 283 ADRA2C isa FPLX 000019 ADRA -HGNC 281 ADRA2A isa FPLX 000020 ADRA2 -HGNC 282 ADRA2B isa FPLX 000020 ADRA2 -HGNC 283 ADRA2C isa FPLX 000020 ADRA2 -HGNC 285 ADRB1 isa FPLX 000021 ADRB -HGNC 286 ADRB2 isa FPLX 000021 ADRB -HGNC 288 ADRB3 isa FPLX 000021 ADRB -HGNC 289 GRK2 isa FPLX 000022 ADRBK -HGNC 290 GRK3 isa FPLX 000022 ADRBK -HGNC 402 ALDH1A1 isa FPLX 000024 ALDH -HGNC 15472 ALDH1A2 isa FPLX 000024 ALDH -HGNC 409 ALDH1A3 isa FPLX 000024 ALDH -HGNC 404 ALDH2 isa FPLX 000024 ALDH -HGNC 405 ALDH3A1 isa FPLX 000024 ALDH -HGNC 403 ALDH3A2 isa FPLX 000024 ALDH -HGNC 410 ALDH3B1 isa FPLX 000024 ALDH -HGNC 408 ALDH5A1 isa FPLX 000024 ALDH -HGNC 877 ALDH7A1 isa FPLX 000024 ALDH -HGNC 412 ALDH9A1 isa FPLX 000024 ALDH -HGNC 414 ALDOA isa FPLX 000025 ALDO -HGNC 417 ALDOB isa FPLX 000025 ALDO -HGNC 418 ALDOC isa FPLX 000025 ALDO -HGNC 600 APOA1 isa FPLX 000051 APOA -HGNC 601 APOA2 isa FPLX 000051 APOA -HGNC 602 APOA4 isa FPLX 000051 APOA -HGNC 17288 APOA5 isa FPLX 000051 APOA -FPLX 000051 APOA isa FPLX 000052 Apolipoprotein -HGNC 613 APOE isa FPLX 000052 Apolipoprotein -HGNC 711 ARRB1 isa FPLX 000055 ARRB -HGNC 712 ARRB2 isa FPLX 000055 ARRB -HGNC 16489 ATG4A isa FPLX 000056 ATG4 -HGNC 20790 ATG4B isa FPLX 000056 ATG4 -HGNC 16040 ATG4C isa FPLX 000056 ATG4 -HGNC 20789 ATG4D isa FPLX 000056 ATG4 -HGNC 903 AXIN1 isa FPLX 000062 AXIN -HGNC 904 AXIN2 isa FPLX 000062 AXIN -HGNC 590 BIRC2 isa FPLX 000066 BIRC -HGNC 591 BIRC3 isa FPLX 000066 BIRC -HGNC 593 BIRC5 isa FPLX 000066 BIRC -HGNC 13516 BIRC6 isa FPLX 000066 BIRC -HGNC 13702 BIRC7 isa FPLX 000066 BIRC -HGNC 14878 BIRC8 isa FPLX 000066 BIRC -HGNC 7634 NAIP isa FPLX 000066 BIRC -HGNC 592 XIAP isa FPLX 000066 BIRC -HGNC 4214 GDF1 isa FPLX 000067 BMP -HGNC 4217 GDF2 isa FPLX 000067 BMP -HGNC 4218 GDF3 isa FPLX 000067 BMP -HGNC 4220 GDF5 isa FPLX 000067 BMP -HGNC 4221 GDF6 isa FPLX 000067 BMP -HGNC 4222 GDF7 isa FPLX 000067 BMP -FPLX 000069 BMP_receptor_type_I isa FPLX 000068 BMP_receptor -FPLX 000070 BMP_receptor_type_II isa FPLX 000068 BMP_receptor -HGNC 171 ACVR1 isa FPLX 000069 BMP_receptor_type_I -HGNC 1076 BMPR1A isa FPLX 000069 BMP_receptor_type_I -HGNC 1077 BMPR1B isa FPLX 000069 BMP_receptor_type_I -HGNC 173 ACVR2A isa FPLX 000070 BMP_receptor_type_II -HGNC 174 ACVR2B isa FPLX 000070 BMP_receptor_type_II -HGNC 1078 BMPR2 isa FPLX 000070 BMP_receptor_type_II -HGNC 1442 CALM1 isa FPLX 000075 CALM -HGNC 1445 CALM2 isa FPLX 000075 CALM -HGNC 1449 CALM3 isa FPLX 000075 CALM -HGNC 1459 CAMK1 isa FPLX 000076 CAMK -HGNC 19341 CAMK1D isa FPLX 000076 CAMK -HGNC 14585 CAMK1G isa FPLX 000076 CAMK -HGNC 1460 CAMK2A isa FPLX 000078 CAMK2_family -HGNC 1461 CAMK2B isa FPLX 000078 CAMK2_family -HGNC 1462 CAMK2D isa FPLX 000078 CAMK2_family -HGNC 1463 CAMK2G isa FPLX 000078 CAMK2_family -HGNC 1464 CAMK4 isa FPLX 000076 CAMK -FPLX 000078 CAMK2_family isa FPLX 000076 CAMK -HGNC 1476 CAPN1 isa FPLX 000079 CAPN -HGNC 1477 CAPN10 isa FPLX 000079 CAPN -HGNC 1478 CAPN11 isa FPLX 000079 CAPN -HGNC 13249 CAPN12 isa FPLX 000079 CAPN -HGNC 16663 CAPN13 isa FPLX 000079 CAPN -HGNC 16664 CAPN14 isa FPLX 000079 CAPN -HGNC 1479 CAPN2 isa FPLX 000079 CAPN -HGNC 1480 CAPN3 isa FPLX 000079 CAPN -HGNC 1482 CAPN5 isa FPLX 000079 CAPN -HGNC 1483 CAPN6 isa FPLX 000079 CAPN -HGNC 1484 CAPN7 isa FPLX 000079 CAPN -HGNC 1486 CAPN9 isa FPLX 000079 CAPN -HGNC 11182 CAPN15 isa FPLX 000079 CAPN -HGNC 1485 CAPN8 isa FPLX 000079 CAPN -HGNC 1863 CES1 isa FPLX 000080 Carboxylesterase -HGNC 1864 CES2 isa FPLX 000080 Carboxylesterase -HGNC 1865 CES3 isa FPLX 000080 Carboxylesterase -HGNC 26741 CES4A isa FPLX 000080 Carboxylesterase -HGNC 26459 CES5A isa FPLX 000080 Carboxylesterase -HGNC 1527 CAV1 isa FPLX 000083 CAV -HGNC 1528 CAV2 isa FPLX 000083 CAV -HGNC 1529 CAV3 isa FPLX 000083 CAV -HGNC 3619 FCGR3A isa FPLX 000086 CD16 -HGNC 3620 FCGR3B isa FPLX 000086 CD16 -HGNC 3616 FCGR2A isa FPLX 000088 CD32 -HGNC 3618 FCGR2B isa FPLX 000088 CD32 -HGNC 15626 FCGR2C isa FPLX 000088 CD32 -HGNC 3613 FCGR1A isa FPLX 000089 CD64 -HGNC 3614 FCGR1B isa FPLX 000089 CD64 -HGNC 1725 CDC25A isa FPLX 000091 CDC25 -HGNC 1726 CDC25B isa FPLX 000091 CDC25 -HGNC 1727 CDC25C isa FPLX 000091 CDC25 -HGNC 1748 CDH1 isa FPLX 000074 Cadherin -HGNC 1749 CDH10 isa FPLX 000074 Cadherin -HGNC 1750 CDH11 isa FPLX 000074 Cadherin -HGNC 1751 CDH12 isa FPLX 000074 Cadherin -HGNC 1753 CDH13 isa FPLX 000074 Cadherin -HGNC 1754 CDH15 isa FPLX 000074 Cadherin -HGNC 1755 CDH16 isa FPLX 000074 Cadherin -HGNC 1756 CDH17 isa FPLX 000074 Cadherin -HGNC 1757 CDH18 isa FPLX 000074 Cadherin -HGNC 1758 CDH19 isa FPLX 000074 Cadherin -HGNC 1759 CDH2 isa FPLX 000074 Cadherin -HGNC 1760 CDH20 isa FPLX 000074 Cadherin -HGNC 13251 CDH22 isa FPLX 000074 Cadherin -HGNC 14265 CDH24 isa FPLX 000074 Cadherin -HGNC 1762 CDH3 isa FPLX 000074 Cadherin -HGNC 1763 CDH4 isa FPLX 000074 Cadherin -HGNC 1764 CDH5 isa FPLX 000074 Cadherin -HGNC 1765 CDH6 isa FPLX 000074 Cadherin -HGNC 1766 CDH7 isa FPLX 000074 Cadherin -HGNC 1767 CDH8 isa FPLX 000074 Cadherin -HGNC 1768 CDH9 isa FPLX 000074 Cadherin -HGNC 1833 CEBPA isa FPLX 000097 CEBP -HGNC 1834 CEBPB isa FPLX 000097 CEBP -HGNC 1835 CEBPD isa FPLX 000097 CEBP -HGNC 1837 CEBPG isa FPLX 000097 CEBP -HGNC 1836 CEBPE isa FPLX 000097 CEBP -HGNC 1565 ACKR2 isa FPLX 000100 Chemokine_receptor -HGNC 1602 CCR1 isa FPLX 000100 Chemokine_receptor -HGNC 4474 CCR10 isa FPLX 000100 Chemokine_receptor -HGNC 1603 CCR2 isa FPLX 000100 Chemokine_receptor -HGNC 1604 CCR3 isa FPLX 000100 Chemokine_receptor -HGNC 1605 CCR4 isa FPLX 000100 Chemokine_receptor -HGNC 1606 CCR5 isa FPLX 000100 Chemokine_receptor -HGNC 1607 CCR6 isa FPLX 000100 Chemokine_receptor -HGNC 1608 CCR7 isa FPLX 000100 Chemokine_receptor -HGNC 1609 CCR8 isa FPLX 000100 Chemokine_receptor -HGNC 1610 CCR9 isa FPLX 000100 Chemokine_receptor -HGNC 1611 ACKR4 isa FPLX 000100 Chemokine_receptor -HGNC 1612 CCRL2 isa FPLX 000100 Chemokine_receptor -HGNC 2558 CX3CR1 isa FPLX 000100 Chemokine_receptor -HGNC 6026 CXCR1 isa FPLX 000100 Chemokine_receptor -HGNC 6027 CXCR2 isa FPLX 000100 Chemokine_receptor -HGNC 4540 CXCR3 isa FPLX 000100 Chemokine_receptor -HGNC 2561 CXCR4 isa FPLX 000100 Chemokine_receptor -HGNC 1060 CXCR5 isa FPLX 000100 Chemokine_receptor -HGNC 16647 CXCR6 isa FPLX 000100 Chemokine_receptor -HGNC 23692 ACKR3 isa FPLX 000100 Chemokine_receptor -HGNC 1625 XCR1 isa FPLX 000100 Chemokine_receptor -HGNC 108 ACHE isa FPLX 000101 Cholinesterase -HGNC 983 BCHE isa FPLX 000101 Cholinesterase -HGNC 1950 CHRM1 isa FPLX 000102 CHRM -HGNC 1951 CHRM2 isa FPLX 000102 CHRM -HGNC 1952 CHRM3 isa FPLX 000102 CHRM -HGNC 1953 CHRM4 isa FPLX 000102 CHRM -HGNC 1954 CHRM5 isa FPLX 000102 CHRM -HGNC 2197 COL1A1 isa FPLX 000109 COL1 -HGNC 2198 COL1A2 isa FPLX 000109 COL1 -HGNC 2202 COL4A1 isa FPLX 000110 COL4 -HGNC 2203 COL4A2 isa FPLX 000110 COL4 -HGNC 2204 COL4A3 isa FPLX 000110 COL4 -HGNC 2206 COL4A4 isa FPLX 000110 COL4 -HGNC 2207 COL4A5 isa FPLX 000110 COL4 -HGNC 2208 COL4A6 isa FPLX 000110 COL4 -HGNC 2209 COL5A1 isa FPLX 000111 COL5 -HGNC 2210 COL5A2 isa FPLX 000111 COL5 -HGNC 14864 COL5A3 isa FPLX 000111 COL5 -HGNC 2265 COX4I1 isa FPLX 000114 COX4 -HGNC 16232 COX4I2 isa FPLX 000114 COX4 -HGNC 2277 COX6A1 isa FPLX 000115 COX6A -HGNC 2279 COX6A2 isa FPLX 000115 COX6A -HGNC 2280 COX6B1 isa FPLX 000116 COX6B -HGNC 24380 COX6B2 isa FPLX 000116 COX6B -HGNC 2287 COX7A1 isa FPLX 000117 COX7A -HGNC 2288 COX7A2 isa FPLX 000117 COX7A -HGNC 2291 COX7B isa FPLX 000118 COX7B -HGNC 24381 COX7B2 isa FPLX 000118 COX7B -HGNC 2294 COX8A isa FPLX 000119 COX8 -HGNC 24382 COX8C isa FPLX 000119 COX8 -HGNC 2267 COX5A partof FPLX 000113 COX -HGNC 2269 COX5B partof FPLX 000113 COX -FPLX 000114 COX4 partof FPLX 000113 COX -FPLX 000115 COX6A partof FPLX 000113 COX -FPLX 000116 COX6B partof FPLX 000113 COX -FPLX 000117 COX7A partof FPLX 000113 COX -FPLX 000118 COX7B partof FPLX 000113 COX -FPLX 000119 COX8 partof FPLX 000113 COX -HGNC 2260 COX10 partof FPLX 000113 COX -HGNC 2261 COX11 partof FPLX 000113 COX -HGNC 2263 COX15 partof FPLX 000113 COX -HGNC 2264 COX17 partof FPLX 000113 COX -HGNC 304 CRISP1 isa FPLX 000121 CRISP -HGNC 12024 CRISP2 isa FPLX 000121 CRISP -HGNC 16904 CRISP3 isa FPLX 000121 CRISP -HGNC 2509 CTNNA1 isa FPLX 000126 CTNNA -HGNC 2510 CTNNA2 isa FPLX 000126 CTNNA -HGNC 2511 CTNNA3 isa FPLX 000126 CTNNA -HGNC 2551 CUL1 isa FPLX 000127 CUL -HGNC 2552 CUL2 isa FPLX 000127 CUL -HGNC 2553 CUL3 isa FPLX 000127 CUL -HGNC 2554 CUL4A isa FPLX 000127 CUL -HGNC 2555 CUL4B isa FPLX 000127 CUL -HGNC 2556 CUL5 isa FPLX 000127 CUL -HGNC 21024 CUL7 isa FPLX 000127 CUL -FPLX 000128 CXCL_ELR_negative isa FPLX 000099 Chemokine -FPLX 000129 CXCL_ELR_positive isa FPLX 000099 Chemokine -HGNC 10637 CXCL10 isa FPLX 000128 CXCL_ELR_negative -HGNC 10638 CXCL11 isa FPLX 000128 CXCL_ELR_negative -HGNC 10672 CXCL12 isa FPLX 000128 CXCL_ELR_negative -HGNC 10639 CXCL13 isa FPLX 000128 CXCL_ELR_negative -HGNC 10640 CXCL14 isa FPLX 000128 CXCL_ELR_negative -HGNC 7098 CXCL9 isa FPLX 000128 CXCL_ELR_negative -HGNC 8861 PF4 isa FPLX 000128 CXCL_ELR_negative -HGNC 4602 CXCL1 isa FPLX 000129 CXCL_ELR_positive -HGNC 4603 CXCL2 isa FPLX 000129 CXCL_ELR_positive -HGNC 4604 CXCL3 isa FPLX 000129 CXCL_ELR_positive -HGNC 10642 CXCL5 isa FPLX 000129 CXCL_ELR_positive -HGNC 10643 CXCL6 isa FPLX 000129 CXCL_ELR_positive -HGNC 6025 CXCL8 isa FPLX 000129 CXCL_ELR_positive -HGNC 9240 PPBP isa FPLX 000129 CXCL_ELR_positive -HGNC 10664 CWC27 isa FPLX 000134 Cyclophilin -HGNC 9253 PPIA isa FPLX 000134 Cyclophilin -HGNC 9255 PPIB isa FPLX 000134 Cyclophilin -HGNC 9256 PPIC isa FPLX 000134 Cyclophilin -HGNC 9257 PPID isa FPLX 000134 Cyclophilin -HGNC 9258 PPIE isa FPLX 000134 Cyclophilin -HGNC 9259 PPIF isa FPLX 000134 Cyclophilin -HGNC 14651 PPIH isa FPLX 000134 Cyclophilin -HGNC 9260 PPIL1 isa FPLX 000134 Cyclophilin -HGNC 9261 PPIL2 isa FPLX 000134 Cyclophilin -HGNC 9262 PPIL3 isa FPLX 000134 Cyclophilin -HGNC 15702 PPIL4 isa FPLX 000134 Cyclophilin -HGNC 21557 PPIL6 isa FPLX 000134 Cyclophilin -HGNC 28954 PPWD1 isa FPLX 000134 Cyclophilin -HGNC 24369 PPIAL4A isa FPLX 000134 Cyclophilin -HGNC 33995 PPIAL4C isa FPLX 000134 Cyclophilin -HGNC 33996 PPIAL4G isa FPLX 000134 Cyclophilin -HGNC 2730 DDR1 isa FPLX 000136 DDR -HGNC 2731 DDR2 isa FPLX 000136 DDR -HGNC 3048 DSG1 isa FPLX 000138 Desmoglein -HGNC 3049 DSG2 isa FPLX 000138 Desmoglein -HGNC 3050 DSG3 isa FPLX 000138 Desmoglein -HGNC 21307 DSG4 isa FPLX 000138 Desmoglein -HGNC 2849 DGKA isa FPLX 000140 DGK -HGNC 2850 DGKB isa FPLX 000140 DGK -HGNC 2851 DGKD isa FPLX 000140 DGK -HGNC 2853 DGKG isa FPLX 000140 DGK -HGNC 2854 DGKH isa FPLX 000140 DGK -HGNC 2856 DGKQ isa FPLX 000140 DGK -HGNC 2857 DGKZ isa FPLX 000140 DGK -HGNC 2852 DGKE isa FPLX 000140 DGK -HGNC 2855 DGKI isa FPLX 000140 DGK -HGNC 32395 DGKK isa FPLX 000140 DGK -HGNC 2972 DNM1 isa FPLX 000142 DNM -HGNC 2974 DNM2 isa FPLX 000142 DNM -HGNC 29125 DNM3 isa FPLX 000142 DNM -HGNC 3020 DRD1 isa FPLX 000143 DRD -HGNC 3023 DRD2 isa FPLX 000143 DRD -HGNC 3024 DRD3 isa FPLX 000143 DRD -HGNC 3025 DRD4 isa FPLX 000143 DRD -HGNC 3026 DRD5 isa FPLX 000143 DRD -HGNC 3084 DVL1 isa FPLX 000145 DVL -HGNC 3086 DVL2 isa FPLX 000145 DVL -HGNC 3087 DVL3 isa FPLX 000145 DVL -HGNC 3113 E2F1 isa FPLX 000147 E2F -HGNC 3114 E2F2 isa FPLX 000147 E2F -HGNC 3115 E2F3 isa FPLX 000147 E2F -HGNC 3118 E2F4 isa FPLX 000147 E2F -HGNC 3119 E2F5 isa FPLX 000147 E2F -HGNC 3120 E2F6 isa FPLX 000147 E2F -HGNC 23820 E2F7 isa FPLX 000147 E2F -HGNC 24727 E2F8 isa FPLX 000147 E2F -HGNC 3176 EDN1 isa FPLX 000149 EDN -HGNC 3177 EDN2 isa FPLX 000149 EDN -HGNC 3178 EDN3 isa FPLX 000149 EDN -HGNC 651 AREG isa FPLX 000150 EGFR_ligand -HGNC 3229 EGF isa FPLX 000150 EGFR_ligand -HGNC 11765 TGFA isa FPLX 000150 EGFR_ligand -HGNC 3059 HBEGF isa FPLX 000150 EGFR_ligand -HGNC 1121 BTC isa FPLX 000150 EGFR_ligand -HGNC 3443 EREG isa FPLX 000150 EGFR_ligand -HGNC 17470 EPGN isa FPLX 000150 EGFR_ligand -HGNC 3238 EGR1 isa FPLX 000151 EGR -HGNC 3239 EGR2 isa FPLX 000151 EGR -HGNC 3240 EGR3 isa FPLX 000151 EGR -HGNC 3241 EGR4 isa FPLX 000151 EGR -HGNC 3282 EIF4A1 isa FPLX 000153 EIF4A -HGNC 3284 EIF4A2 isa FPLX 000153 EIF4A -HGNC 18683 EIF4A3 isa FPLX 000153 EIF4A -HGNC 913 AZU1 isa FPLX 000156 ELA -HGNC 3308 CELA1 isa FPLX 000156 ELA -HGNC 24609 CELA2A isa FPLX 000156 ELA -HGNC 29995 CELA2B isa FPLX 000156 ELA -HGNC 15944 CELA3A isa FPLX 000156 ELA -HGNC 15945 CELA3B isa FPLX 000156 ELA -HGNC 2523 CTRC isa FPLX 000156 ELA -HGNC 3309 ELANE isa FPLX 000156 ELA -HGNC 9495 PRTN3 isa FPLX 000156 ELA -HGNC 3350 ENO1 isa FPLX 000157 ENO -HGNC 3353 ENO2 isa FPLX 000157 ENO -HGNC 3354 ENO3 isa FPLX 000157 ENO -HGNC 31670 ENO4 isa FPLX 000157 ENO -HGNC 3385 EPHA1 isa FPLX 000158 Ephrin_receptor -HGNC 3386 EPHA2 isa FPLX 000158 Ephrin_receptor -HGNC 3387 EPHA3 isa FPLX 000158 Ephrin_receptor -HGNC 3388 EPHA4 isa FPLX 000158 Ephrin_receptor -HGNC 3389 EPHA5 isa FPLX 000158 Ephrin_receptor -HGNC 19296 EPHA6 isa FPLX 000158 Ephrin_receptor -HGNC 3390 EPHA7 isa FPLX 000158 Ephrin_receptor -HGNC 3391 EPHA8 isa FPLX 000158 Ephrin_receptor -HGNC 3392 EPHB1 isa FPLX 000158 Ephrin_receptor -HGNC 3393 EPHB2 isa FPLX 000158 Ephrin_receptor -HGNC 3394 EPHB3 isa FPLX 000158 Ephrin_receptor -HGNC 3395 EPHB4 isa FPLX 000158 Ephrin_receptor -HGNC 3396 EPHB6 isa FPLX 000158 Ephrin_receptor -HGNC 19987 EPHA10 isa FPLX 000158 Ephrin_receptor -HGNC 21604 EPN1 isa FPLX 000159 EPN -HGNC 18639 EPN2 isa FPLX 000159 EPN -HGNC 18235 EPN3 isa FPLX 000159 EPN -HGNC 23186 CLINT1 isa FPLX 000159 EPN -HGNC 3467 ESR1 isa FPLX 000162 ESR -HGNC 3468 ESR2 isa FPLX 000162 ESR -HGNC 3757 FLOT1 isa FPLX 000170 FLOT -HGNC 3758 FLOT2 isa FPLX 000170 FLOT -HGNC 3760 FLRT1 isa FPLX 000171 FLRT -HGNC 3761 FLRT2 isa FPLX 000171 FLRT -HGNC 3762 FLRT3 isa FPLX 000171 FLRT -HGNC 4038 FZD1 isa FPLX 000177 FZD -HGNC 4039 FZD10 isa FPLX 000177 FZD -HGNC 4040 FZD2 isa FPLX 000177 FZD -HGNC 4041 FZD3 isa FPLX 000177 FZD -HGNC 4042 FZD4 isa FPLX 000177 FZD -HGNC 4043 FZD5 isa FPLX 000177 FZD -HGNC 4044 FZD6 isa FPLX 000177 FZD -HGNC 4045 FZD7 isa FPLX 000177 FZD -HGNC 4046 FZD8 isa FPLX 000177 FZD -HGNC 4047 FZD9 isa FPLX 000177 FZD -HGNC 4075 GABRA1 isa FPLX 000179 GABR -HGNC 4076 GABRA2 isa FPLX 000179 GABR -HGNC 4077 GABRA3 isa FPLX 000179 GABR -HGNC 4078 GABRA4 isa FPLX 000179 GABR -HGNC 4079 GABRA5 isa FPLX 000179 GABR -HGNC 4080 GABRA6 isa FPLX 000179 GABR -HGNC 4081 GABRB1 isa FPLX 000179 GABR -HGNC 4082 GABRB2 isa FPLX 000179 GABR -HGNC 4083 GABRB3 isa FPLX 000179 GABR -HGNC 4084 GABRD isa FPLX 000179 GABR -HGNC 4085 GABRE isa FPLX 000179 GABR -HGNC 4086 GABRG1 isa FPLX 000179 GABR -HGNC 4087 GABRG2 isa FPLX 000179 GABR -HGNC 4088 GABRG3 isa FPLX 000179 GABR -HGNC 4089 GABRP isa FPLX 000179 GABR -HGNC 14454 GABRQ isa FPLX 000179 GABR -HGNC 4090 GABRR1 isa FPLX 000179 GABR -HGNC 4091 GABRR2 isa FPLX 000179 GABR -HGNC 17969 GABRR3 isa FPLX 000179 GABR -HGNC 905 AXL isa FPLX 000183 GAS6_receptor -HGNC 7027 MERTK isa FPLX 000183 GAS6_receptor -HGNC 12446 TYRO3 isa FPLX 000183 GAS6_receptor -HGNC 4170 GATA1 isa FPLX 000184 GATA -HGNC 4171 GATA2 isa FPLX 000184 GATA -HGNC 4172 GATA3 isa FPLX 000184 GATA -HGNC 4173 GATA4 isa FPLX 000184 GATA -HGNC 15802 GATA5 isa FPLX 000184 GATA -HGNC 4174 GATA6 isa FPLX 000184 GATA -HGNC 4396 GNB1 isa FPLX 000210 G_beta -HGNC 4398 GNB2 isa FPLX 000210 G_beta -HGNC 4400 GNB3 isa FPLX 000210 G_beta -HGNC 20731 GNB4 isa FPLX 000210 G_beta -HGNC 4401 GNB5 isa FPLX 000210 G_beta -HGNC 4402 GNG10 isa FPLX 000211 G_gamma -HGNC 4403 GNG11 isa FPLX 000211 G_gamma -HGNC 19663 GNG12 isa FPLX 000211 G_gamma -HGNC 14131 GNG13 isa FPLX 000211 G_gamma -HGNC 4404 GNG2 isa FPLX 000211 G_gamma -HGNC 4405 GNG3 isa FPLX 000211 G_gamma -HGNC 4407 GNG4 isa FPLX 000211 G_gamma -HGNC 4408 GNG5 isa FPLX 000211 G_gamma -HGNC 4410 GNG7 isa FPLX 000211 G_gamma -HGNC 19664 GNG8 isa FPLX 000211 G_gamma -HGNC 4411 GNGT1 isa FPLX 000211 G_gamma -HGNC 4412 GNGT2 isa FPLX 000211 G_gamma -HGNC 4553 GPX1 isa FPLX 000190 GPX -HGNC 4554 GPX2 isa FPLX 000190 GPX -HGNC 4555 GPX3 isa FPLX 000190 GPX -HGNC 4556 GPX4 isa FPLX 000190 GPX -HGNC 4557 GPX5 isa FPLX 000190 GPX -HGNC 4558 GPX6 isa FPLX 000190 GPX -HGNC 4559 GPX7 isa FPLX 000190 GPX -HGNC 33100 GPX8 isa FPLX 000190 GPX -HGNC 4571 GRIA1 isa FPLX 000191 GRIA -HGNC 4572 GRIA2 isa FPLX 000191 GRIA -HGNC 4573 GRIA3 isa FPLX 000191 GRIA -HGNC 4574 GRIA4 isa FPLX 000191 GRIA -FPLX 000022 ADRBK isa FPLX 000192 GRK -HGNC 10013 GRK1 isa FPLX 000192 GRK -HGNC 4543 GRK4 isa FPLX 000192 GRK -HGNC 4544 GRK5 isa FPLX 000192 GRK -HGNC 4545 GRK6 isa FPLX 000192 GRK -HGNC 17031 GRK7 isa FPLX 000192 GRK -HGNC 4593 GRM1 isa FPLX 000193 GRM -HGNC 4594 GRM2 isa FPLX 000193 GRM -HGNC 4595 GRM3 isa FPLX 000193 GRM -HGNC 4596 GRM4 isa FPLX 000193 GRM -HGNC 4597 GRM5 isa FPLX 000193 GRM -HGNC 4598 GRM6 isa FPLX 000193 GRM -HGNC 4599 GRM7 isa FPLX 000193 GRM -HGNC 4600 GRM8 isa FPLX 000193 GRM -HGNC 4626 GSTA1 isa FPLX 000195 GST -HGNC 4627 GSTA2 isa FPLX 000195 GST -HGNC 4628 GSTA3 isa FPLX 000195 GST -HGNC 4629 GSTA4 isa FPLX 000195 GST -HGNC 19662 GSTA5 isa FPLX 000195 GST -HGNC 16906 GSTK1 isa FPLX 000195 GST -HGNC 4632 GSTM1 isa FPLX 000195 GST -HGNC 4634 GSTM2 isa FPLX 000195 GST -HGNC 4635 GSTM3 isa FPLX 000195 GST -HGNC 4636 GSTM4 isa FPLX 000195 GST -HGNC 4637 GSTM5 isa FPLX 000195 GST -HGNC 13312 GSTO1 isa FPLX 000195 GST -HGNC 23064 GSTO2 isa FPLX 000195 GST -HGNC 4638 GSTP1 isa FPLX 000195 GST -HGNC 4641 GSTT1 isa FPLX 000195 GST -HGNC 4642 GSTT2 isa FPLX 000195 GST -HGNC 4643 GSTZ1 isa FPLX 000195 GST -HGNC 33437 GSTT2B isa FPLX 000195 GST -HGNC 4688 GUCY2C isa FPLX 000205 GUCY -HGNC 4689 GUCY2D isa FPLX 000205 GUCY -HGNC 4691 GUCY2F isa FPLX 000205 GUCY -HGNC 7943 NPR1 isa FPLX 000205 GUCY -HGNC 7944 NPR2 isa FPLX 000205 GUCY -HGNC 2865 DHH isa FPLX 000226 Hedgehog -HGNC 5956 IHH isa FPLX 000226 Hedgehog -HGNC 10848 SHH isa FPLX 000226 Hedgehog -HGNC 5192 HES1 isa FPLX 000228 HES -HGNC 16005 HES2 isa FPLX 000228 HES -HGNC 26226 HES3 isa FPLX 000228 HES -HGNC 24149 HES4 isa FPLX 000228 HES -HGNC 19764 HES5 isa FPLX 000228 HES -HGNC 18254 HES6 isa FPLX 000228 HES -HGNC 15977 HES7 isa FPLX 000228 HES -HGNC 4947 HLA-DRA isa FPLX 000239 HLA_DR -HGNC 4948 HLA-DRB1 isa FPLX 000239 HLA_DR -HGNC 4951 HLA-DRB3 isa FPLX 000239 HLA_DR -HGNC 4952 HLA-DRB4 isa FPLX 000239 HLA_DR -HGNC 4953 HLA-DRB5 isa FPLX 000239 HLA_DR -HGNC 5013 HMOX1 isa FPLX 000240 HMOX -HGNC 5014 HMOX2 isa FPLX 000240 HMOX -HGNC 19022 HSPA12A isa FPLX 000244 HSPA -HGNC 16193 HSPA12B isa FPLX 000244 HSPA -HGNC 11375 HSPA13 isa FPLX 000244 HSPA -HGNC 29526 HSPA14 isa FPLX 000244 HSPA -HGNC 5232 HSPA1A isa FPLX 000244 HSPA -HGNC 5233 HSPA1B isa FPLX 000244 HSPA -HGNC 5234 HSPA1L isa FPLX 000244 HSPA -HGNC 5235 HSPA2 isa FPLX 000244 HSPA -HGNC 5237 HSPA4 isa FPLX 000244 HSPA -HGNC 17041 HSPA4L isa FPLX 000244 HSPA -HGNC 5238 HSPA5 isa FPLX 000244 HSPA -HGNC 5239 HSPA6 isa FPLX 000244 HSPA -HGNC 5241 HSPA8 isa FPLX 000244 HSPA -HGNC 5244 HSPA9 isa FPLX 000244 HSPA -HGNC 16969 HSPH1 isa FPLX 000244 HSPA -HGNC 16931 HYOU1 isa FPLX 000244 HSPA -HGNC 5246 HSPB1 isa FPLX 000245 HSPB -HGNC 5247 HSPB2 isa FPLX 000245 HSPB -HGNC 30171 HSPB8 isa FPLX 000245 HSPB -HGNC 5469 IGFBP1 isa FPLX 000248 IGFBP -HGNC 5471 IGFBP2 isa FPLX 000248 IGFBP -HGNC 5472 IGFBP3 isa FPLX 000248 IGFBP -HGNC 5473 IGFBP4 isa FPLX 000248 IGFBP -HGNC 5474 IGFBP5 isa FPLX 000248 IGFBP -HGNC 5475 IGFBP6 isa FPLX 000248 IGFBP -HGNC 5476 IGFBP7 isa FPLX 000248 IGFBP -HGNC 1974 CHUK isa FPLX 000251 IKK_family -HGNC 5960 IKBKB isa FPLX 000251 IKK_family -HGNC 5961 IKBKG isa FPLX 000251 IKK_family -HGNC 14552 IKBKE isa FPLX 000251 IKK_family -HGNC 11584 TBK1 isa FPLX 000251 IKK_family -HGNC 5465 IGF1R isa FPLX 000260 INSR -HGNC 6081 INS isa FPLX 000259 INS -HGNC 6091 INSR isa FPLX 000260 INSR -HGNC 6093 INSRR isa FPLX 000260 INSR -HGNC 6125 IRS1 isa FPLX 000264 IRS -HGNC 6126 IRS2 isa FPLX 000264 IRS -HGNC 6128 IRS4 isa FPLX 000264 IRS -HGNC 14358 IRX1 isa FPLX 000265 IRX -HGNC 14359 IRX2 isa FPLX 000265 IRX -HGNC 14360 IRX3 isa FPLX 000265 IRX -HGNC 6129 IRX4 isa FPLX 000265 IRX -HGNC 14361 IRX5 isa FPLX 000265 IRX -HGNC 14675 IRX6 isa FPLX 000265 IRX -HGNC 23729 MKX isa FPLX 000265 IRX -HGNC 6357 KLK1 isa FPLX 000271 KLK -HGNC 6358 KLK10 isa FPLX 000271 KLK -HGNC 6359 KLK11 isa FPLX 000271 KLK -HGNC 6360 KLK12 isa FPLX 000271 KLK -HGNC 6361 KLK13 isa FPLX 000271 KLK -HGNC 6362 KLK14 isa FPLX 000271 KLK -HGNC 20453 KLK15 isa FPLX 000271 KLK -HGNC 6363 KLK2 isa FPLX 000271 KLK -HGNC 6364 KLK3 isa FPLX 000271 KLK -HGNC 6365 KLK4 isa FPLX 000271 KLK -HGNC 6366 KLK5 isa FPLX 000271 KLK -HGNC 6367 KLK6 isa FPLX 000271 KLK -HGNC 6368 KLK7 isa FPLX 000271 KLK -HGNC 6369 KLK8 isa FPLX 000271 KLK -HGNC 6370 KLK9 isa FPLX 000271 KLK -HGNC 6371 KLKB1 isa FPLX 000271 KLK -HGNC 6776 MAF isa FPLX 000279 MAF -HGNC 23145 MAFA isa FPLX 000279 MAF -HGNC 6408 MAFB isa FPLX 000279 MAF -HGNC 6780 MAFF isa FPLX 000279 MAF -HGNC 6781 MAFG isa FPLX 000279 MAF -HGNC 6782 MAFK isa FPLX 000279 MAF -HGNC 6881 MAPK8 isa FPLX 000267 JNK -HGNC 6886 MAPK9 isa FPLX 000267 JNK -HGNC 6872 MAPK10 isa FPLX 000267 JNK -FPLX 000267 JNK isa FPLX 000283 MAPK -HGNC 6993 MEF2A isa FPLX 000285 MEF2 -HGNC 6996 MEF2C isa FPLX 000285 MEF2 -HGNC 6997 MEF2D isa FPLX 000285 MEF2 -HGNC 6995 MEF2B isa FPLX 000285 MEF2 -HGNC 7567 MYH1 isa FPLX 000295 MYH -HGNC 7568 MYH10 isa FPLX 000295 MYH -HGNC 7569 MYH11 isa FPLX 000295 MYH -HGNC 7571 MYH13 isa FPLX 000295 MYH -HGNC 23212 MYH14 isa FPLX 000295 MYH -HGNC 31073 MYH15 isa FPLX 000295 MYH -HGNC 7572 MYH2 isa FPLX 000295 MYH -HGNC 7573 MYH3 isa FPLX 000295 MYH -HGNC 7574 MYH4 isa FPLX 000295 MYH -HGNC 7576 MYH6 isa FPLX 000295 MYH -HGNC 7577 MYH7 isa FPLX 000295 MYH -HGNC 15906 MYH7B isa FPLX 000295 MYH -HGNC 7578 MYH8 isa FPLX 000295 MYH -HGNC 7579 MYH9 isa FPLX 000295 MYH -HGNC 7602 MYO5A isa FPLX 000295 MYH -HGNC 7582 MYL1 isa FPLX 000297 MYL_alkali -HGNC 7584 MYL3 isa FPLX 000297 MYL_alkali -HGNC 7585 MYL4 isa FPLX 000297 MYL_alkali -HGNC 7587 MYL6 isa FPLX 000297 MYL_alkali -HGNC 29823 MYL6B isa FPLX 000297 MYL_alkali -HGNC 29825 MYL10 isa FPLX 000298 MYL_regulatory -HGNC 16701 MYL12A isa FPLX 000298 MYL_regulatory -HGNC 29827 MYL12B isa FPLX 000298 MYL_regulatory -HGNC 7583 MYL2 isa FPLX 000298 MYL_regulatory -HGNC 7586 MYL5 isa FPLX 000298 MYL_regulatory -HGNC 21719 MYL7 isa FPLX 000298 MYL_regulatory -HGNC 15754 MYL9 isa FPLX 000298 MYL_regulatory -HGNC 29824 MYLPF isa FPLX 000298 MYL_regulatory -HGNC 7583 MYL2 isa FPLX 000299 MYL_slow -HGNC 7584 MYL3 isa FPLX 000299 MYL_slow -HGNC 29823 MYL6B isa FPLX 000299 MYL_slow -FPLX 000297 MYL_alkali isa FPLX 000296 MYL -FPLX 000298 MYL_regulatory isa FPLX 000296 MYL -FPLX 000299 MYL_slow isa FPLX 000296 MYL -HGNC 17933 KAT8 isa FPLX 000300 MYST -HGNC 17016 KAT7 isa FPLX 000300 MYST -HGNC 13013 KAT6A isa FPLX 000300 MYST -HGNC 17582 KAT6B isa FPLX 000300 MYST -HGNC 5275 KAT5 isa FPLX 000300 MYST -HGNC 7668 NCOA1 isa FPLX 000305 NCOA -HGNC 7669 NCOA2 isa FPLX 000305 NCOA -HGNC 7670 NCOA3 isa FPLX 000305 NCOA -HGNC 7672 NCOR1 isa FPLX 000306 NCOR -HGNC 7673 NCOR2 isa FPLX 000306 NCOR -HGNC 7679 NDRG1 isa FPLX 000307 NDRG -HGNC 14460 NDRG2 isa FPLX 000307 NDRG -HGNC 14462 NDRG3 isa FPLX 000307 NDRG -HGNC 14466 NDRG4 isa FPLX 000307 NDRG -HGNC 17045 NKD1 isa FPLX 000315 NKD -HGNC 17046 NKD2 isa FPLX 000315 NKD -HGNC 7872 NOS1 isa FPLX 000316 NOS -HGNC 7873 NOS2 isa FPLX 000316 NOS -HGNC 7876 NOS3 isa FPLX 000316 NOS -HGNC 7881 NOTCH1 isa FPLX 000317 Notch -HGNC 7882 NOTCH2 isa FPLX 000317 Notch -HGNC 7883 NOTCH3 isa FPLX 000317 Notch -HGNC 7884 NOTCH4 isa FPLX 000317 Notch -HGNC 7997 NRG1 isa FPLX 000319 NRG_1_2 -HGNC 7998 NRG2 isa FPLX 000319 NRG_1_2 -HGNC 7999 NRG3 isa FPLX 000320 NRG_3_4 -HGNC 29862 NRG4 isa FPLX 000320 NRG_3_4 -FPLX 000319 NRG_1_2 isa FPLX 000318 NRG -FPLX 000320 NRG_3_4 isa FPLX 000318 NRG -HGNC 8031 NTRK1 isa FPLX 000321 NTRK -HGNC 8032 NTRK2 isa FPLX 000321 NTRK -HGNC 8033 NTRK3 isa FPLX 000321 NTRK -HGNC 8533 P2RX1 isa FPLX 000324 P2RX -HGNC 15459 P2RX2 isa FPLX 000324 P2RX -HGNC 8534 P2RX3 isa FPLX 000324 P2RX -HGNC 8535 P2RX4 isa FPLX 000324 P2RX -HGNC 8536 P2RX5 isa FPLX 000324 P2RX -HGNC 8538 P2RX6 isa FPLX 000324 P2RX -HGNC 8537 P2RX7 isa FPLX 000324 P2RX -HGNC 8539 P2RY1 isa FPLX 000325 P2RY -HGNC 8541 P2RY2 isa FPLX 000325 P2RY -HGNC 8542 P2RY4 isa FPLX 000325 P2RY -HGNC 8543 P2RY6 isa FPLX 000325 P2RY -HGNC 15524 P2RY8 isa FPLX 000325 P2RY -HGNC 19906 P2RY10 isa FPLX 000325 P2RY -HGNC 8540 P2RY11 isa FPLX 000325 P2RY -HGNC 18124 P2RY12 isa FPLX 000325 P2RY -HGNC 4537 P2RY13 isa FPLX 000325 P2RY -HGNC 16442 P2RY14 isa FPLX 000325 P2RY -HGNC 4478 LPAR4 isa FPLX 000325 P2RY -HGNC 15520 LPAR6 isa FPLX 000325 P2RY -HGNC 14652 PARVA isa FPLX 000332 PARV -HGNC 14653 PARVB isa FPLX 000332 PARV -HGNC 14654 PARVG isa FPLX 000332 PARV -HGNC 8632 PBX1 isa FPLX 000334 PBX -HGNC 8633 PBX2 isa FPLX 000334 PBX -HGNC 8634 PBX3 isa FPLX 000334 PBX -HGNC 13403 PBX4 isa FPLX 000334 PBX -HGNC 8774 PDE1A isa FPLX 000336 PDE1 -HGNC 8775 PDE1B isa FPLX 000336 PDE1 -HGNC 8776 PDE1C isa FPLX 000336 PDE1 -HGNC 8777 PDE2A isa FPLX 000335 PDE -HGNC 8778 PDE3A isa FPLX 000337 PDE3 -HGNC 8779 PDE3B isa FPLX 000337 PDE3 -HGNC 8780 PDE4A isa FPLX 000338 PDE4 -HGNC 8781 PDE4B isa FPLX 000338 PDE4 -HGNC 8782 PDE4C isa FPLX 000338 PDE4 -HGNC 8783 PDE4D isa FPLX 000338 PDE4 -HGNC 8785 PDE6A isa FPLX 000339 PDE6 -HGNC 8786 PDE6B isa FPLX 000339 PDE6 -HGNC 8787 PDE6C isa FPLX 000339 PDE6 -HGNC 8791 PDE7A isa FPLX 000340 PDE7 -HGNC 8792 PDE7B isa FPLX 000340 PDE7 -HGNC 8793 PDE8A isa FPLX 000341 PDE8 -HGNC 8794 PDE8B isa FPLX 000341 PDE8 -HGNC 8795 PDE9A isa FPLX 000335 PDE -HGNC 8772 PDE10A isa FPLX 000335 PDE -HGNC 8773 PDE11A isa FPLX 000335 PDE -FPLX 000336 PDE1 isa FPLX 000335 PDE -FPLX 000337 PDE3 isa FPLX 000335 PDE -FPLX 000338 PDE4 isa FPLX 000335 PDE -FPLX 000339 PDE6 isa FPLX 000335 PDE -FPLX 000340 PDE7 isa FPLX 000335 PDE -FPLX 000341 PDE8 isa FPLX 000335 PDE -HGNC 8809 PDK1 isa FPLX 000353 PDK -HGNC 8810 PDK2 isa FPLX 000353 PDK -HGNC 8811 PDK3 isa FPLX 000353 PDK -HGNC 8812 PDK4 isa FPLX 000353 PDK -HGNC 8881 PFN1 isa FPLX 000355 PFN -HGNC 8882 PFN2 isa FPLX 000355 PFN -HGNC 18627 PFN3 isa FPLX 000355 PFN -HGNC 31103 PFN4 isa FPLX 000355 PFN -HGNC 8975 PIK3CA isa FPLX 000359 PI3K_p110 -HGNC 8976 PIK3CB isa FPLX 000359 PI3K_p110 -HGNC 8977 PIK3CD isa FPLX 000359 PI3K_p110 -HGNC 8978 PIK3CG isa FPLX 000359 PI3K_p110 -HGNC 8979 PIK3R1 isa FPLX 000360 PI3K_p85 -HGNC 8980 PIK3R2 isa FPLX 000360 PI3K_p85 -HGNC 8981 PIK3R3 isa FPLX 000361 PIK3R_I -HGNC 8982 PIK3R4 isa FPLX 000361 PIK3R_I -HGNC 30035 PIK3R5 isa FPLX 000361 PIK3R_I -HGNC 27101 PIK3R6 isa FPLX 000361 PIK3R_I -FPLX 000360 PI3K_p85 isa FPLX 000361 PIK3R_I -FPLX 000359 PI3K_p110 partof FPLX 000358 PI3K -FPLX 000361 PIK3R_I partof FPLX 000358 PI3K -HGNC 9017 PKIA isa FPLX 000365 PKI -HGNC 9018 PKIB isa FPLX 000365 PKI -HGNC 9019 PKIG isa FPLX 000365 PKI -HGNC 9030 PLA2G1B isa FPLX 000366 PLA2 -HGNC 9031 PLA2G2A isa FPLX 000367 PLA2G2 -HGNC 9032 PLA2G2C isa FPLX 000367 PLA2G2 -HGNC 9033 PLA2G2D isa FPLX 000367 PLA2G2 -HGNC 13414 PLA2G2E isa FPLX 000367 PLA2G2 -HGNC 30040 PLA2G2F isa FPLX 000367 PLA2G2 -HGNC 17934 PLA2G3 isa FPLX 000366 PLA2 -HGNC 9035 PLA2G4A isa FPLX 000368 PLA2G4 -HGNC 9037 PLA2G4C isa FPLX 000368 PLA2G4 -HGNC 30038 PLA2G4D isa FPLX 000368 PLA2G4 -HGNC 9038 PLA2G5 isa FPLX 000366 PLA2 -HGNC 9039 PLA2G6 isa FPLX 000366 PLA2 -HGNC 9040 PLA2G7 isa FPLX 000366 PLA2 -HGNC 9029 PLA2G10 isa FPLX 000366 PLA2 -HGNC 18554 PLA2G12A isa FPLX 000366 PLA2 -HGNC 18555 PLA2G12B isa FPLX 000366 PLA2 -FPLX 000367 PLA2G2 isa FPLX 000366 PLA2 -FPLX 000368 PLA2G4 isa FPLX 000366 PLA2 -HGNC 15917 PLCB1 isa FPLX 000370 PLCB -HGNC 9055 PLCB2 isa FPLX 000370 PLCB -HGNC 9056 PLCB3 isa FPLX 000370 PLCB -HGNC 9059 PLCB4 isa FPLX 000370 PLCB -HGNC 9060 PLCD1 isa FPLX 000371 PLCD -HGNC 9061 PLCD3 isa FPLX 000371 PLCD -HGNC 9062 PLCD4 isa FPLX 000371 PLCD -HGNC 17175 PLCE1 isa FPLX 000369 PLC -HGNC 9065 PLCG1 isa FPLX 000372 PLCG -HGNC 9066 PLCG2 isa FPLX 000372 PLCG -HGNC 19218 PLCZ1 isa FPLX 000369 PLC -FPLX 000370 PLCB isa FPLX 000369 PLC -FPLX 000371 PLCD isa FPLX 000369 PLC -FPLX 000372 PLCG isa FPLX 000369 PLC -HGNC 9067 PLD1 isa FPLX 000373 PLD -HGNC 9068 PLD2 isa FPLX 000373 PLD -HGNC 17158 PLD3 isa FPLX 000373 PLD -HGNC 23792 PLD4 isa FPLX 000373 PLD -HGNC 26879 PLD5 isa FPLX 000373 PLD -HGNC 30447 PLD6 isa FPLX 000373 PLD -HGNC 9228 PLPP1 isa FPLX 000374 PPAP2 -HGNC 9230 PLPP2 isa FPLX 000374 PPAP2 -HGNC 9229 PLPP3 isa FPLX 000374 PPAP2 -HGNC 9232 PPARA isa FPLX 000375 PPAR -HGNC 9235 PPARD isa FPLX 000375 PPAR -HGNC 9236 PPARG isa FPLX 000375 PPAR -HGNC 9281 PPP1CA isa FPLX 000377 PPP1C -HGNC 9282 PPP1CB isa FPLX 000377 PPP1C -HGNC 9283 PPP1CC isa FPLX 000377 PPP1C -HGNC 9284 PPP1R10 isa FPLX 000378 PPP1R -HGNC 9285 PPP1R11 isa FPLX 000378 PPP1R -HGNC 7618 PPP1R12A isa FPLX 000378 PPP1R -HGNC 7619 PPP1R12B isa FPLX 000378 PPP1R -HGNC 14947 PPP1R12C isa FPLX 000378 PPP1R -HGNC 14950 PPP1R13B isa FPLX 000378 PPP1R -HGNC 14871 PPP1R14A isa FPLX 000378 PPP1R -HGNC 9057 PPP1R14B isa FPLX 000378 PPP1R -HGNC 14952 PPP1R14C isa FPLX 000378 PPP1R -HGNC 14953 PPP1R14D isa FPLX 000378 PPP1R -HGNC 14375 PPP1R15A isa FPLX 000378 PPP1R -HGNC 14951 PPP1R15B isa FPLX 000378 PPP1R -HGNC 14941 PPP1R16A isa FPLX 000378 PPP1R -HGNC 15850 PPP1R16B isa FPLX 000378 PPP1R -HGNC 9286 PPP1R1A isa FPLX 000378 PPP1R -HGNC 9287 PPP1R1B isa FPLX 000378 PPP1R -HGNC 14940 PPP1R1C isa FPLX 000378 PPP1R -HGNC 9288 PPP1R2 isa FPLX 000378 PPP1R -HGNC 9291 PPP1R3A isa FPLX 000378 PPP1R -HGNC 14942 PPP1R3B isa FPLX 000378 PPP1R -HGNC 9293 PPP1R3C isa FPLX 000378 PPP1R -HGNC 9294 PPP1R3D isa FPLX 000378 PPP1R -HGNC 14944 PPP1R3F isa FPLX 000378 PPP1R -HGNC 9295 PPP1R7 isa FPLX 000378 PPP1R -HGNC 9296 PPP1R8 isa FPLX 000378 PPP1R -HGNC 14946 PPP1R9A isa FPLX 000378 PPP1R -HGNC 9298 PPP1R9B isa FPLX 000378 PPP1R -FPLX 000377 PPP1C partof FPLX 000376 PPP1 -FPLX 000378 PPP1R partof FPLX 000376 PPP1 -HGNC 20785 PPM1J isa FPLX 000380 PPP2C -HGNC 9299 PPP2CA isa FPLX 000380 PPP2C -HGNC 9300 PPP2CB isa FPLX 000380 PPP2C -HGNC 9302 PPP2R1A isa FPLX 000381 PPP2R_A -HGNC 9303 PPP2R1B isa FPLX 000381 PPP2R_A -HGNC 9304 PPP2R2A isa FPLX 000382 PPP2R_B -HGNC 9305 PPP2R2B isa FPLX 000382 PPP2R_B -HGNC 9306 PPP2R2C isa FPLX 000382 PPP2R_B -HGNC 23732 PPP2R2D isa FPLX 000382 PPP2R_B -HGNC 9307 PPP2R3A isa FPLX 000382 PPP2R_B -HGNC 13417 PPP2R3B isa FPLX 000382 PPP2R_B -HGNC 9308 PTPA isa FPLX 000382 PPP2R_B -HGNC 9309 PPP2R5A isa FPLX 000382 PPP2R_B -HGNC 9310 PPP2R5B isa FPLX 000382 PPP2R_B -HGNC 9311 PPP2R5C isa FPLX 000382 PPP2R_B -HGNC 9312 PPP2R5D isa FPLX 000382 PPP2R_B -HGNC 9313 PPP2R5E isa FPLX 000382 PPP2R_B -FPLX 000380 PPP2C partof FPLX 000379 PPP2 -FPLX 000381 PPP2R_A partof FPLX 000379 PPP2 -FPLX 000382 PPP2R_B partof FPLX 000379 PPP2 -HGNC 9314 PPP3CA isa FPLX 000384 PPP3C -HGNC 9315 PPP3CB isa FPLX 000384 PPP3C -HGNC 9316 PPP3CC isa FPLX 000384 PPP3C -HGNC 9317 PPP3R1 isa FPLX 000385 PPP3R -HGNC 9318 PPP3R2 isa FPLX 000385 PPP3R -FPLX 000384 PPP3C partof FPLX 000383 PPP3 -FPLX 000385 PPP3R partof FPLX 000383 PPP3 -HGNC 9352 PRDX1 isa FPLX 000388 PRDX -HGNC 9353 PRDX2 isa FPLX 000388 PRDX -HGNC 9354 PRDX3 isa FPLX 000388 PRDX -HGNC 17169 PRDX4 isa FPLX 000388 PRDX -HGNC 9355 PRDX5 isa FPLX 000388 PRDX -HGNC 16753 PRDX6 isa FPLX 000388 PRDX -HGNC 9388 PRKAR1A isa FPLX 000390 PRKAR -HGNC 9390 PRKAR1B isa FPLX 000390 PRKAR -HGNC 9391 PRKAR2A isa FPLX 000390 PRKAR -HGNC 9392 PRKAR2B isa FPLX 000390 PRKAR -HGNC 9380 PRKACA isa FPLX 000389 PRKAC -HGNC 9381 PRKACB isa FPLX 000389 PRKAC -HGNC 9382 PRKACG isa FPLX 000389 PRKAC -FPLX 000390 PRKAR partof FPLX 000363 PKA -FPLX 000389 PRKAC partof FPLX 000363 PKA -HGNC 9393 PRKCA isa FPLX 000364 PKC -HGNC 9395 PRKCB isa FPLX 000364 PKC -HGNC 9399 PRKCD isa FPLX 000364 PKC -HGNC 9401 PRKCE isa FPLX 000364 PKC -HGNC 9402 PRKCG isa FPLX 000364 PKC -HGNC 9403 PRKCH isa FPLX 000364 PKC -HGNC 9404 PRKCI isa FPLX 000364 PKC -HGNC 9410 PRKCQ isa FPLX 000364 PKC -HGNC 9412 PRKCZ isa FPLX 000364 PKC -HGNC 9408 PRKD3 isa FPLX 000364 PKC -HGNC 9414 PRKG1 isa FPLX 000391 PRKG -HGNC 9416 PRKG2 isa FPLX 000391 PRKG -HGNC 9593 PTGER1 isa FPLX 000395 PTGER -HGNC 9594 PTGER2 isa FPLX 000395 PTGER -HGNC 9595 PTGER3 isa FPLX 000395 PTGER -HGNC 9596 PTGER4 isa FPLX 000395 PTGER -HGNC 9759 RAB10 isa FPLX 000397 RAB -HGNC 9760 RAB11A isa FPLX 000397 RAB -HGNC 9761 RAB11B isa FPLX 000397 RAB -HGNC 31332 RAB12 isa FPLX 000397 RAB -HGNC 9762 RAB13 isa FPLX 000397 RAB -HGNC 16524 RAB14 isa FPLX 000397 RAB -HGNC 20150 RAB15 isa FPLX 000397 RAB -HGNC 16523 RAB17 isa FPLX 000397 RAB -HGNC 14244 RAB18 isa FPLX 000397 RAB -HGNC 19982 RAB19 isa FPLX 000397 RAB -HGNC 9758 RAB1A isa FPLX 000397 RAB -HGNC 18370 RAB1B isa FPLX 000397 RAB -HGNC 23683 RAB1C isa FPLX 000397 RAB -HGNC 18260 RAB20 isa FPLX 000397 RAB -HGNC 18263 RAB21 isa FPLX 000397 RAB -HGNC 9764 RAB22A isa FPLX 000397 RAB -HGNC 14263 RAB23 isa FPLX 000397 RAB -HGNC 9765 RAB24 isa FPLX 000397 RAB -HGNC 18238 RAB25 isa FPLX 000397 RAB -HGNC 14259 RAB26 isa FPLX 000397 RAB -HGNC 9766 RAB27A isa FPLX 000397 RAB -HGNC 9767 RAB27B isa FPLX 000397 RAB -HGNC 9768 RAB28 isa FPLX 000397 RAB -HGNC 9763 RAB2A isa FPLX 000397 RAB -HGNC 20246 RAB2B isa FPLX 000397 RAB -HGNC 9770 RAB30 isa FPLX 000397 RAB -HGNC 9771 RAB31 isa FPLX 000397 RAB -HGNC 9772 RAB32 isa FPLX 000397 RAB -HGNC 9773 RAB33A isa FPLX 000397 RAB -HGNC 16075 RAB33B isa FPLX 000397 RAB -HGNC 16519 RAB34 isa FPLX 000397 RAB -HGNC 9774 RAB35 isa FPLX 000397 RAB -HGNC 9775 RAB36 isa FPLX 000397 RAB -HGNC 30268 RAB37 isa FPLX 000397 RAB -HGNC 9776 RAB38 isa FPLX 000397 RAB -HGNC 16521 RAB39A isa FPLX 000397 RAB -HGNC 16499 RAB39B isa FPLX 000397 RAB -HGNC 9777 RAB3A isa FPLX 000397 RAB -HGNC 9778 RAB3B isa FPLX 000397 RAB -HGNC 30269 RAB3C isa FPLX 000397 RAB -HGNC 9779 RAB3D isa FPLX 000397 RAB -HGNC 18283 RAB40A isa FPLX 000397 RAB -HGNC 25410 RAB40AL isa FPLX 000397 RAB -HGNC 18284 RAB40B isa FPLX 000397 RAB -HGNC 18285 RAB40C isa FPLX 000397 RAB -HGNC 18293 RAB41 isa FPLX 000397 RAB -HGNC 28702 RAB42 isa FPLX 000397 RAB -HGNC 19983 RAB43 isa FPLX 000397 RAB -HGNC 21068 RAB44 isa FPLX 000397 RAB -HGNC 9781 RAB4A isa FPLX 000397 RAB -HGNC 9782 RAB4B isa FPLX 000397 RAB -HGNC 9783 RAB5A isa FPLX 000397 RAB -HGNC 9784 RAB5B isa FPLX 000397 RAB -HGNC 9785 RAB5C isa FPLX 000397 RAB -HGNC 9786 RAB6A isa FPLX 000397 RAB -HGNC 14902 RAB6B isa FPLX 000397 RAB -HGNC 16525 RAB6C isa FPLX 000397 RAB -HGNC 9788 RAB7A isa FPLX 000397 RAB -HGNC 30513 RAB7B isa FPLX 000397 RAB -HGNC 9789 RAB29 isa FPLX 000397 RAB -HGNC 7007 RAB8A isa FPLX 000397 RAB -HGNC 30273 RAB8B isa FPLX 000397 RAB -HGNC 9792 RAB9A isa FPLX 000397 RAB -HGNC 14090 RAB9B isa FPLX 000397 RAB -HGNC 9799 RABL2A isa FPLX 000397 RAB -HGNC 9800 RABL2B isa FPLX 000397 RAB -HGNC 18072 RABL3 isa FPLX 000397 RAB -HGNC 21895 IFT22 isa FPLX 000397 RAB -HGNC 9864 RARA isa FPLX 000403 RAR -HGNC 9865 RARB isa FPLX 000403 RAR -HGNC 9866 RARG isa FPLX 000403 RAR -HGNC 9982 RFX1 isa FPLX 000412 RFX -HGNC 9983 RFX2 isa FPLX 000412 RFX -HGNC 9984 RFX3 isa FPLX 000412 RFX -HGNC 9985 RFX4 isa FPLX 000412 RFX -HGNC 9986 RFX5 isa FPLX 000412 RFX -HGNC 21478 RFX6 isa FPLX 000412 RFX -HGNC 25777 RFX7 isa FPLX 000412 RFX -HGNC 37253 RFX8 isa FPLX 000412 RFX -HGNC 10256 ROR1 isa FPLX 000420 ROR -HGNC 10257 ROR2 isa FPLX 000420 ROR -HGNC 10477 RXRA isa FPLX 000424 RXR -HGNC 10478 RXRB isa FPLX 000424 RXR -HGNC 10479 RXRG isa FPLX 000424 RXR -HGNC 20846 HRNR isa FPLX 000426 S100A -HGNC 10486 S100A1 isa FPLX 000426 S100A -HGNC 10487 S100A10 isa FPLX 000426 S100A -HGNC 10488 S100A11 isa FPLX 000426 S100A -HGNC 10489 S100A12 isa FPLX 000426 S100A -HGNC 10490 S100A13 isa FPLX 000426 S100A -HGNC 18901 S100A14 isa FPLX 000426 S100A -HGNC 20441 S100A16 isa FPLX 000426 S100A -HGNC 10492 S100A2 isa FPLX 000426 S100A -HGNC 10493 S100A3 isa FPLX 000426 S100A -HGNC 10494 S100A4 isa FPLX 000426 S100A -HGNC 10495 S100A5 isa FPLX 000426 S100A -HGNC 10496 S100A6 isa FPLX 000426 S100A -HGNC 10497 S100A7 isa FPLX 000426 S100A -HGNC 21657 S100A7A isa FPLX 000426 S100A -HGNC 10498 S100A8 isa FPLX 000426 S100A -HGNC 10499 S100A9 isa FPLX 000426 S100A -HGNC 31796 TCHHL1 isa FPLX 000426 S100A -FPLX 000426 S100A isa FPLX 000425 S100 -HGNC 10500 S100B isa FPLX 000425 S100 -HGNC 1436 S100G isa FPLX 000425 S100 -HGNC 10504 S100P isa FPLX 000425 S100 -HGNC 30367 S100Z isa FPLX 000425 S100 -HGNC 3165 S1PR1 isa FPLX 000427 S1PR -HGNC 3169 S1PR2 isa FPLX 000427 S1PR -HGNC 3167 S1PR3 isa FPLX 000427 S1PR -HGNC 3170 S1PR4 isa FPLX 000427 S1PR -HGNC 14299 S1PR5 isa FPLX 000427 S1PR -HGNC 10571 SCD isa FPLX 000429 SCD -HGNC 21088 SCD5 isa FPLX 000429 SCD -HGNC 3311 SERPINB1 isa FPLX 000431 SERPINB -HGNC 8584 SERPINB2 isa FPLX 000431 SERPINB -HGNC 10569 SERPINB3 isa FPLX 000431 SERPINB -HGNC 10570 SERPINB4 isa FPLX 000431 SERPINB -HGNC 8949 SERPINB5 isa FPLX 000431 SERPINB -HGNC 8950 SERPINB6 isa FPLX 000431 SERPINB -HGNC 13902 SERPINB7 isa FPLX 000431 SERPINB -HGNC 8952 SERPINB8 isa FPLX 000431 SERPINB -HGNC 8955 SERPINB9 isa FPLX 000431 SERPINB -HGNC 8942 SERPINB10 isa FPLX 000431 SERPINB -HGNC 14221 SERPINB11 isa FPLX 000431 SERPINB -HGNC 14220 SERPINB12 isa FPLX 000431 SERPINB -HGNC 8944 SERPINB13 isa FPLX 000431 SERPINB -HGNC 11005 SLC2A1 isa FPLX 000434 SLC2A -HGNC 11006 SLC2A2 isa FPLX 000434 SLC2A -HGNC 11007 SLC2A3 isa FPLX 000434 SLC2A -HGNC 11009 SLC2A4 isa FPLX 000434 SLC2A -HGNC 11010 SLC2A5 isa FPLX 000434 SLC2A -HGNC 11011 SLC2A6 isa FPLX 000434 SLC2A -HGNC 13445 SLC2A7 isa FPLX 000434 SLC2A -HGNC 13812 SLC2A8 isa FPLX 000434 SLC2A -HGNC 13446 SLC2A9 isa FPLX 000434 SLC2A -HGNC 13444 SLC2A10 isa FPLX 000434 SLC2A -HGNC 14239 SLC2A11 isa FPLX 000434 SLC2A -HGNC 18067 SLC2A12 isa FPLX 000434 SLC2A -HGNC 18301 SLC2A14 isa FPLX 000434 SLC2A -HGNC 6767 SMAD1 isa FPLX 000441 SMAD -HGNC 6767 SMAD1 isa FPLX 000442 SMAD1_5_9 -HGNC 6768 SMAD2 isa FPLX 000443 SMAD2_3 -HGNC 6769 SMAD3 isa FPLX 000443 SMAD2_3 -HGNC 6770 SMAD4 isa FPLX 000441 SMAD -HGNC 6771 SMAD5 isa FPLX 000441 SMAD -HGNC 6771 SMAD5 isa FPLX 000442 SMAD1_5_9 -HGNC 6772 SMAD6 isa FPLX 000441 SMAD -HGNC 6773 SMAD7 isa FPLX 000441 SMAD -HGNC 6774 SMAD9 isa FPLX 000441 SMAD -HGNC 6774 SMAD9 isa FPLX 000442 SMAD1_5_9 -FPLX 000443 SMAD2_3 isa FPLX 000441 SMAD -FPLX 000442 SMAD1_5_9 isa FPLX 000441 SMAD -HGNC 11111 SMC1A isa FPLX 000444 SMC1 -HGNC 11112 SMC1B isa FPLX 000444 SMC1 -HGNC 11128 SNAI1 isa FPLX 000446 SNAI -HGNC 11094 SNAI2 isa FPLX 000446 SNAI -HGNC 18411 SNAI3 isa FPLX 000446 SNAI -HGNC 3697 FGR isa FPLX 000451 SRC -HGNC 4037 FYN isa FPLX 000451 SRC -HGNC 11283 SRC isa FPLX 000451 SRC -HGNC 12841 YES1 isa FPLX 000451 SRC -HGNC 11289 SREBF1 isa FPLX 000452 SREBF -HGNC 11290 SREBF2 isa FPLX 000452 SREBF -HGNC 43 TAP1 isa FPLX 000459 TAP -HGNC 44 TAP2 isa FPLX 000459 TAP -HGNC 50 ABCB9 isa FPLX 000459 TAP -HGNC 6551 LEF1 isa FPLX 000460 TCF_LEF -HGNC 11639 TCF7 isa FPLX 000460 TCF_LEF -HGNC 11640 TCF7L1 isa FPLX 000460 TCF_LEF -HGNC 11641 TCF7L2 isa FPLX 000460 TCF_LEF -HGNC 11742 TFAP2A isa FPLX 000463 TFAP2 -HGNC 11743 TFAP2B isa FPLX 000463 TFAP2 -HGNC 11744 TFAP2C isa FPLX 000463 TFAP2 -HGNC 15581 TFAP2D isa FPLX 000463 TFAP2 -HGNC 30774 TFAP2E isa FPLX 000463 TFAP2 -HGNC 11766 TGFB1 isa FPLX 000465 TGFB -HGNC 11768 TGFB2 isa FPLX 000465 TGFB -HGNC 11769 TGFB3 isa FPLX 000465 TGFB -HGNC 11772 TGFBR1 isa FPLX 000466 TGFBR -HGNC 11773 TGFBR2 isa FPLX 000466 TGFBR -HGNC 11774 TGFBR3 isa FPLX 000466 TGFBR -HGNC 11785 THBS1 isa FPLX 000467 THBS -HGNC 11786 THBS2 isa FPLX 000467 THBS -HGNC 11787 THBS3 isa FPLX 000467 THBS -HGNC 11788 THBS4 isa FPLX 000467 THBS -HGNC 2227 COMP isa FPLX 000467 THBS -HGNC 11796 THRA isa FPLX 000468 THR -HGNC 11799 THRB isa FPLX 000468 THR -HGNC 5318 TNC isa FPLX 000473 TN -HGNC 22942 TNN isa FPLX 000473 TN -HGNC 11953 TNR isa FPLX 000473 TN -HGNC 11976 TNXB isa FPLX 000473 TN -HGNC 11989 TOP2A isa FPLX 000476 TOP2 -HGNC 11990 TOP2B isa FPLX 000476 TOP2 -HGNC 12019 TPSAB1 isa FPLX 000481 Tryptase -HGNC 14120 TPSB2 isa FPLX 000481 Tryptase -HGNC 14118 TPSD1 isa FPLX 000481 Tryptase -HGNC 14134 TPSG1 isa FPLX 000481 Tryptase -HGNC 12435 TXN isa FPLX 000487 TXN -HGNC 17772 TXN2 isa FPLX 000487 TXN -HGNC 12437 TXNRD1 isa FPLX 000488 TXNRD -HGNC 18155 TXNRD2 isa FPLX 000488 TXNRD -HGNC 20667 TXNRD3 isa FPLX 000488 TXNRD -HGNC 1734 CDC34 isa FPLX 000489 UBE2 -HGNC 12472 UBE2A isa FPLX 000489 UBE2 -HGNC 12473 UBE2B isa FPLX 000489 UBE2 -HGNC 15937 UBE2C isa FPLX 000489 UBE2 -HGNC 12474 UBE2D1 isa FPLX 000489 UBE2 -HGNC 12475 UBE2D2 isa FPLX 000489 UBE2 -HGNC 12476 UBE2D3 isa FPLX 000489 UBE2 -HGNC 21647 UBE2D4 isa FPLX 000489 UBE2 -HGNC 12477 UBE2E1 isa FPLX 000489 UBE2 -HGNC 12478 UBE2E2 isa FPLX 000489 UBE2 -HGNC 12479 UBE2E3 isa FPLX 000489 UBE2 -HGNC 12480 UBE2F isa FPLX 000489 UBE2 -HGNC 12482 UBE2G1 isa FPLX 000489 UBE2 -HGNC 12483 UBE2G2 isa FPLX 000489 UBE2 -HGNC 12484 UBE2H isa FPLX 000489 UBE2 -HGNC 12485 UBE2I isa FPLX 000489 UBE2 -HGNC 17598 UBE2J1 isa FPLX 000489 UBE2 -HGNC 19268 UBE2J2 isa FPLX 000489 UBE2 -HGNC 12488 UBE2L3 isa FPLX 000489 UBE2 -HGNC 12490 UBE2L6 isa FPLX 000489 UBE2 -HGNC 12491 UBE2M isa FPLX 000489 UBE2 -HGNC 12492 UBE2N isa FPLX 000489 UBE2 -HGNC 31710 UBE2NL isa FPLX 000489 UBE2 -HGNC 15698 UBE2Q1 isa FPLX 000489 UBE2 -HGNC 19907 UBE2R2 isa FPLX 000489 UBE2 -HGNC 17895 UBE2S isa FPLX 000489 UBE2 -HGNC 12494 UBE2V1 isa FPLX 000489 UBE2 -HGNC 12495 UBE2V2 isa FPLX 000489 UBE2 -HGNC 25616 UBE2W isa FPLX 000489 UBE2 -HGNC 12657 VAV1 isa FPLX 000494 VAV -HGNC 12658 VAV2 isa FPLX 000494 VAV -HGNC 12659 VAV3 isa FPLX 000494 VAV -HGNC 12680 VEGFA isa FPLX 000495 VEGF -HGNC 12681 VEGFB isa FPLX 000495 VEGF -HGNC 12682 VEGFC isa FPLX 000495 VEGF -HGNC 3708 VEGFD isa FPLX 000495 VEGF -HGNC 8893 PGF isa FPLX 000495 VEGF -HGNC 3763 FLT1 isa FPLX 000496 VEGFR -HGNC 3767 FLT4 isa FPLX 000496 VEGFR -HGNC 6307 KDR isa FPLX 000496 VEGFR -HGNC 76 ABL1 isa FPLX 000003 ABL_family -HGNC 77 ABL2 isa FPLX 000003 ABL_family -HGNC 5309 HUS1 partof FPLX 000001 9_1_1 -HGNC 9806 RAD1 partof FPLX 000001 9_1_1 -HGNC 9827 RAD9A partof FPLX 000001 9_1_1 -HGNC 566 AP3B1 partof FPLX 000016 Adaptor_protein_III -HGNC 568 AP3D1 partof FPLX 000016 Adaptor_protein_III -HGNC 2013 AP3S1 partof FPLX 000016 Adaptor_protein_III -HGNC 571 AP3S2 partof FPLX 000016 Adaptor_protein_III -HGNC 537 ANXA2 partof FPLX 000047 Annexin_II_heterotetramer -HGNC 10487 S100A10 partof FPLX 000047 Annexin_II_heterotetramer -HGNC 703 ARPC1A partof FPLX 000054 Arp2_3_protein -HGNC 704 ARPC1B partof FPLX 000054 Arp2_3_protein -HGNC 705 ARPC2 partof FPLX 000054 Arp2_3_protein -HGNC 706 ARPC3 partof FPLX 000054 Arp2_3_protein -HGNC 707 ARPC4 partof FPLX 000054 Arp2_3_protein -HGNC 708 ARPC5 partof FPLX 000054 Arp2_3_protein -HGNC 23366 ARPC5L partof FPLX 000054 Arp2_3_protein -HGNC 986 BCKDHA partof FPLX 000064 BCKDC -HGNC 987 BCKDHB partof FPLX 000064 BCKDC -HGNC 2698 DBT partof FPLX 000064 BCKDC -HGNC 2898 DLD partof FPLX 000064 BCKDC -HGNC 1241 C1QA partof FPLX 000072 C1 -HGNC 1242 C1QB partof FPLX 000072 C1 -HGNC 1245 C1QC partof FPLX 000072 C1 -HGNC 1246 C1R partof FPLX 000072 C1 -HGNC 1247 C1S partof FPLX 000072 C1 -HGNC 1241 C1QA partof FPLX 000073 C1q -HGNC 1242 C1QB partof FPLX 000073 C1q -HGNC 1460 CAMK2A partof FPLX 000077 CAMK2_complex -HGNC 1461 CAMK2B partof FPLX 000077 CAMK2_complex -HGNC 1462 CAMK2D partof FPLX 000077 CAMK2_complex -HGNC 1463 CAMK2G partof FPLX 000077 CAMK2_complex -HGNC 10899 SKP1 partof FPLX 000084 CBF3 -HGNC 1615 CCT2 partof FPLX 000085 CCT_complex -HGNC 1616 CCT3 partof FPLX 000085 CCT_complex -HGNC 1617 CCT4 partof FPLX 000085 CCT_complex -HGNC 1618 CCT5 partof FPLX 000085 CCT_complex -HGNC 1620 CCT6A partof FPLX 000085 CCT_complex -HGNC 1621 CCT6B partof FPLX 000085 CCT_complex -HGNC 1622 CCT7 partof FPLX 000085 CCT_complex -HGNC 1623 CCT8 partof FPLX 000085 CCT_complex -HGNC 11655 TCP1 partof FPLX 000085 CCT_complex -HGNC 1677 CD247 partof FPLX 000087 CD3 -HGNC 1673 CD3D partof FPLX 000087 CD3 -HGNC 1674 CD3E partof FPLX 000087 CD3 -HGNC 1675 CD3G partof FPLX 000087 CD3 -HGNC 1956 CHRNA2 partof FPLX 000103 CHRN -HGNC 1957 CHRNA3 partof FPLX 000103 CHRN -HGNC 1958 CHRNA4 partof FPLX 000103 CHRN -HGNC 1959 CHRNA5 partof FPLX 000103 CHRN -HGNC 15963 CHRNA6 partof FPLX 000103 CHRN -HGNC 1960 CHRNA7 partof FPLX 000103 CHRN -HGNC 1962 CHRNB2 partof FPLX 000103 CHRN -HGNC 1963 CHRNB3 partof FPLX 000103 CHRN -HGNC 1964 CHRNB4 partof FPLX 000103 CHRN -HGNC 2090 CLTA partof FPLX 000105 Clathrin -HGNC 2091 CLTB partof FPLX 000105 Clathrin -HGNC 2092 CLTC partof FPLX 000105 Clathrin -HGNC 9811 RAD21 partof FPLX 000108 Cohesin -HGNC 2468 SMC3 partof FPLX 000108 Cohesin -HGNC 9234 MED1 partof FPLX 000122 CRSP -HGNC 2370 MED14 partof FPLX 000122 CRSP -HGNC 2375 MED17 partof FPLX 000122 CRSP -HGNC 2372 MED23 partof FPLX 000122 CRSP -HGNC 2376 MED26 partof FPLX 000122 CRSP -HGNC 2377 MED27 partof FPLX 000122 CRSP -HGNC 2378 MED7 partof FPLX 000122 CRSP -HGNC 2961 DYNC1H1 partof FPLX 000135 Cytoplasmic_dynein -HGNC 2963 DYNC1I1 partof FPLX 000135 Cytoplasmic_dynein -HGNC 2964 DYNC1I2 partof FPLX 000135 Cytoplasmic_dynein -HGNC 18745 DYNC1LI1 partof FPLX 000135 Cytoplasmic_dynein -HGNC 2966 DYNC1LI2 partof FPLX 000135 Cytoplasmic_dynein -HGNC 15476 DYNLL1 partof FPLX 000135 Cytoplasmic_dynein -HGNC 15468 DYNLRB1 partof FPLX 000135 Cytoplasmic_dynein -HGNC 15467 DYNLRB2 partof FPLX 000135 Cytoplasmic_dynein -HGNC 9175 POLD1 partof FPLX 000141 DNA_polymerase_delta -HGNC 9176 POLD2 partof FPLX 000141 DNA_polymerase_delta -HGNC 20932 POLD3 partof FPLX 000141 DNA_polymerase_delta -HGNC 14106 POLD4 partof FPLX 000141 DNA_polymerase_delta -HGNC 2666 DAG1 partof FPLX 000139 DGC -HGNC 2928 DMD partof FPLX 000139 DGC -HGNC 3057 DTNA partof FPLX 000139 DGC -HGNC 3058 DTNB partof FPLX 000139 DGC -HGNC 7872 NOS1 partof FPLX 000139 DGC -HGNC 10805 SGCA partof FPLX 000139 DGC -HGNC 10806 SGCB partof FPLX 000139 DGC -HGNC 10807 SGCD partof FPLX 000139 DGC -HGNC 10808 SGCE partof FPLX 000139 DGC -HGNC 14075 SGCZ partof FPLX 000139 DGC -HGNC 11167 SNTA1 partof FPLX 000139 DGC -HGNC 11168 SNTB1 partof FPLX 000139 DGC -HGNC 13740 SNTG1 partof FPLX 000139 DGC -HGNC 13741 SNTG2 partof FPLX 000139 DGC -HGNC 11322 SSPN partof FPLX 000139 DGC -HGNC 12635 UTRN partof FPLX 000139 DGC -HGNC 3257 EIF2B1 partof FPLX 000152 EIF2B -HGNC 3258 EIF2B2 partof FPLX 000152 EIF2B -HGNC 3259 EIF2B3 partof FPLX 000152 EIF2B -HGNC 3260 EIF2B4 partof FPLX 000152 EIF2B -HGNC 3261 EIF2B5 partof FPLX 000152 EIF2B -HGNC 3661 FGA partof FPLX 000169 Fibrinogen -HGNC 3662 FGB partof FPLX 000169 Fibrinogen -HGNC 3694 FGG partof FPLX 000169 Fibrinogen -HGNC 1885 CGA partof FPLX 000175 FSH -HGNC 3964 FSHB partof FPLX 000175 FSH -HGNC 29509 APH1A partof FPLX 000181 Gamma_secretase -HGNC 9508 PSEN1 partof FPLX 000181 Gamma_secretase -HGNC 30100 PSENEN partof FPLX 000181 Gamma_secretase -HGNC 4446 GPAA1 partof FPLX 000189 GPIT -HGNC 8965 PIGK partof FPLX 000189 GPIT -HGNC 14937 PIGS partof FPLX 000189 GPIT -HGNC 14938 PIGT partof FPLX 000189 GPIT -HGNC 15791 PIGU partof FPLX 000189 GPIT -HGNC 4650 GTF2E1 partof FPLX 000196 GTF2E -HGNC 4651 GTF2E2 partof FPLX 000196 GTF2E -HGNC 4652 GTF2F1 partof FPLX 000197 GTF2F -HGNC 4653 GTF2F2 partof FPLX 000197 GTF2F -HGNC 399 ALB partof FPLX 000225 HDL -HGNC 600 APOA1 partof FPLX 000225 HDL -HGNC 601 APOA2 partof FPLX 000225 HDL -HGNC 613 APOE partof FPLX 000225 HDL -HGNC 2095 CLU partof FPLX 000225 HDL -HGNC 4823 HBA1 partof FPLX 000227 Hemoglobin -HGNC 4824 HBA2 partof FPLX 000227 Hemoglobin -HGNC 4827 HBB partof FPLX 000227 Hemoglobin -HGNC 4829 HBD partof FPLX 000227 Hemoglobin -HGNC 4830 HBE1 partof FPLX 000227 Hemoglobin -HGNC 4831 HBG1 partof FPLX 000227 Hemoglobin -HGNC 4832 HBG2 partof FPLX 000227 Hemoglobin -HGNC 4826 HBM partof FPLX 000227 Hemoglobin -HGNC 4833 HBQ1 partof FPLX 000227 Hemoglobin -HGNC 4835 HBZ partof FPLX 000227 Hemoglobin -HGNC 4439 GP1BA partof FPLX 000188 GPIb_IX_V -HGNC 4440 GP1BB partof FPLX 000188 GPIb_IX_V -HGNC 4443 GP5 partof FPLX 000188 GPIb_IX_V -HGNC 4444 GP9 partof FPLX 000188 GPIb_IX_V -HGNC 1974 CHUK partof FPLX 000250 IKK_complex -HGNC 5960 IKBKB partof FPLX 000250 IKK_complex -HGNC 5961 IKBKG partof FPLX 000250 IKK_complex -HGNC 5439 IFNGR1 partof FPLX 000263 Interferon_gamma_receptor -HGNC 5440 IFNGR2 partof FPLX 000263 Interferon_gamma_receptor -HGNC 1148 BUB1 partof FPLX 000270 Kinetochore -HGNC 1149 BUB1B partof FPLX 000270 Kinetochore -HGNC 1151 BUB3 partof FPLX 000270 Kinetochore -HGNC 1854 CENPC partof FPLX 000270 Kinetochore -HGNC 1856 CENPE partof FPLX 000270 Kinetochore -HGNC 1857 CENPF partof FPLX 000270 Kinetochore -HGNC 17268 CENPH partof FPLX 000270 Kinetochore -HGNC 2712 DCTN2 partof FPLX 000270 Kinetochore -HGNC 6391 KIF22 partof FPLX 000270 Kinetochore -HGNC 6763 MAD2L1 partof FPLX 000270 Kinetochore -HGNC 8574 PAFAH1B1 partof FPLX 000270 Kinetochore -HGNC 9508 PSEN1 partof FPLX 000270 Kinetochore -HGNC 9509 PSEN2 partof FPLX 000270 Kinetochore -HGNC 11111 SMC1A partof FPLX 000270 Kinetochore -HGNC 16987 SUGT1 partof FPLX 000270 Kinetochore -HGNC 11124 SUMO3 partof FPLX 000270 Kinetochore -HGNC 13194 ZW10 partof FPLX 000270 Kinetochore -HGNC 6481 LAMA1 partof FPLX 000273 Laminin_111 -HGNC 6486 LAMB1 partof FPLX 000273 Laminin_111 -HGNC 6492 LAMC1 partof FPLX 000273 Laminin_111 -HGNC 6483 LAMA3 partof FPLX 000274 Laminin_332 -HGNC 6490 LAMB3 partof FPLX 000274 Laminin_332 -HGNC 6493 LAMC2 partof FPLX 000274 Laminin_332 -HGNC 1885 CGA partof FPLX 000276 LH -HGNC 6584 LHB partof FPLX 000276 LH -HGNC 1331 C5 partof FPLX 000278 MAC -HGNC 1339 C6 partof FPLX 000278 MAC -HGNC 1346 C7 partof FPLX 000278 MAC -HGNC 1352 C8A partof FPLX 000278 MAC -HGNC 1353 C8B partof FPLX 000278 MAC -HGNC 1354 C8G partof FPLX 000278 MAC -HGNC 1358 C9 partof FPLX 000278 MAC -HGNC 799 ATP1A1 isa FPLX 000057 ATP1A -HGNC 800 ATP1A2 isa FPLX 000057 ATP1A -HGNC 801 ATP1A3 isa FPLX 000057 ATP1A -HGNC 14073 ATP1A4 isa FPLX 000057 ATP1A -HGNC 804 ATP1B1 isa FPLX 000058 ATP1B -HGNC 805 ATP1B2 isa FPLX 000058 ATP1B -HGNC 806 ATP1B3 isa FPLX 000058 ATP1B -HGNC 808 ATP1B4 isa FPLX 000058 ATP1B -FPLX 000057 ATP1A partof FPLX 000303 Na_K_ATPase -FPLX 000058 ATP1B partof FPLX 000303 Na_K_ATPase -HGNC 7455 MT-ND1 partof FPLX 000301 NADH_dehydrogenase -HGNC 7456 MT-ND2 partof FPLX 000301 NADH_dehydrogenase -HGNC 7458 MT-ND3 partof FPLX 000301 NADH_dehydrogenase -HGNC 7459 MT-ND4 partof FPLX 000301 NADH_dehydrogenase -HGNC 7460 MT-ND4L partof FPLX 000301 NADH_dehydrogenase -HGNC 7461 MT-ND5 partof FPLX 000301 NADH_dehydrogenase -HGNC 7462 MT-ND6 partof FPLX 000301 NADH_dehydrogenase -HGNC 2577 CYBA partof FPLX 000302 NADPH_oxidase -HGNC 2578 CYBB partof FPLX 000302 NADPH_oxidase -HGNC 3062 DUOX1 partof FPLX 000302 NADPH_oxidase -HGNC 13273 DUOX2 partof FPLX 000302 NADPH_oxidase -HGNC 7660 NCF1 partof FPLX 000302 NADPH_oxidase -HGNC 7661 NCF2 partof FPLX 000302 NADPH_oxidase -HGNC 7662 NCF4 partof FPLX 000302 NADPH_oxidase -HGNC 7889 NOX1 partof FPLX 000302 NADPH_oxidase -HGNC 7890 NOX3 partof FPLX 000302 NADPH_oxidase -HGNC 7891 NOX4 partof FPLX 000302 NADPH_oxidase -HGNC 14874 NOX5 partof FPLX 000302 NADPH_oxidase -HGNC 9801 RAC1 partof FPLX 000302 NADPH_oxidase -HGNC 7804 NFYA partof FPLX 000314 NFY -HGNC 7805 NFYB partof FPLX 000314 NFY -HGNC 7806 NFYC partof FPLX 000314 NFY -HGNC 1442 CALM1 partof FPLX 000356 PhK -HGNC 8925 PHKA1 partof FPLX 000356 PhK -HGNC 8926 PHKA2 partof FPLX 000356 PhK -HGNC 8927 PHKB partof FPLX 000356 PhK -HGNC 8930 PHKG1 partof FPLX 000356 PhK -HGNC 8931 PHKG2 partof FPLX 000356 PhK -HGNC 1066 BMI1 partof FPLX 000386 PRC1_complex -HGNC 1552 CBX2 partof FPLX 000386 PRC1_complex -HGNC 1554 CBX4 partof FPLX 000386 PRC1_complex -HGNC 15962 CBX8 partof FPLX 000386 PRC1_complex -HGNC 12929 PCGF2 partof FPLX 000386 PRC1_complex -HGNC 3182 PHC1 partof FPLX 000386 PRC1_complex -HGNC 3183 PHC2 partof FPLX 000386 PRC1_complex -HGNC 15682 PHC3 partof FPLX 000386 PRC1_complex -HGNC 8919 PHF1 partof FPLX 000386 PRC1_complex -HGNC 10018 RING1 partof FPLX 000386 PRC1_complex -HGNC 10061 RNF2 partof FPLX 000386 PRC1_complex -HGNC 19003 SCMH1 partof FPLX 000386 PRC1_complex -HGNC 12856 YY1 partof FPLX 000386 PRC1_complex -HGNC 12918 ZNF134 partof FPLX 000386 PRC1_complex -HGNC 3188 EED partof FPLX 000387 PRC2_complex -HGNC 3526 EZH1 partof FPLX 000387 PRC2_complex -HGNC 3527 EZH2 partof FPLX 000387 PRC2_complex -HGNC 17101 SUZ12 partof FPLX 000387 PRC2_complex -HGNC 8653 PCCA partof FPLX 000392 Propionyl_CoA_carboxylase -HGNC 8654 PCCB partof FPLX 000392 Propionyl_CoA_carboxylase -HGNC 9530 PSMA1 partof FPLX 000394 Proteasome -HGNC 9531 PSMA2 partof FPLX 000394 Proteasome -HGNC 9532 PSMA3 partof FPLX 000394 Proteasome -HGNC 9533 PSMA4 partof FPLX 000394 Proteasome -HGNC 9534 PSMA5 partof FPLX 000394 Proteasome -HGNC 9535 PSMA6 partof FPLX 000394 Proteasome -HGNC 9536 PSMA7 partof FPLX 000394 Proteasome -HGNC 22985 PSMA8 partof FPLX 000394 Proteasome -HGNC 9537 PSMB1 partof FPLX 000394 Proteasome -HGNC 9538 PSMB10 partof FPLX 000394 Proteasome -HGNC 9539 PSMB2 partof FPLX 000394 Proteasome -HGNC 9540 PSMB3 partof FPLX 000394 Proteasome -HGNC 9541 PSMB4 partof FPLX 000394 Proteasome -HGNC 9542 PSMB5 partof FPLX 000394 Proteasome -HGNC 9543 PSMB6 partof FPLX 000394 Proteasome -HGNC 9544 PSMB7 partof FPLX 000394 Proteasome -HGNC 9545 PSMB8 partof FPLX 000394 Proteasome -HGNC 9546 PSMB9 partof FPLX 000394 Proteasome -HGNC 9547 PSMC1 partof FPLX 000394 Proteasome -HGNC 9548 PSMC2 partof FPLX 000394 Proteasome -HGNC 9549 PSMC3 partof FPLX 000394 Proteasome -HGNC 9551 PSMC4 partof FPLX 000394 Proteasome -HGNC 9552 PSMC5 partof FPLX 000394 Proteasome -HGNC 9553 PSMC6 partof FPLX 000394 Proteasome -HGNC 9554 PSMD1 partof FPLX 000394 Proteasome -HGNC 9555 PSMD10 partof FPLX 000394 Proteasome -HGNC 9556 PSMD11 partof FPLX 000394 Proteasome -HGNC 9557 PSMD12 partof FPLX 000394 Proteasome -HGNC 9558 PSMD13 partof FPLX 000394 Proteasome -HGNC 16889 PSMD14 partof FPLX 000394 Proteasome -HGNC 9559 PSMD2 partof FPLX 000394 Proteasome -HGNC 9560 PSMD3 partof FPLX 000394 Proteasome -HGNC 9561 PSMD4 partof FPLX 000394 Proteasome -HGNC 9563 PSMD5 partof FPLX 000394 Proteasome -HGNC 9564 PSMD6 partof FPLX 000394 Proteasome -HGNC 9565 PSMD7 partof FPLX 000394 Proteasome -HGNC 9566 PSMD8 partof FPLX 000394 Proteasome -HGNC 9567 PSMD9 partof FPLX 000394 Proteasome -HGNC 9568 PSME1 partof FPLX 000394 Proteasome -HGNC 9569 PSME2 partof FPLX 000394 Proteasome -HGNC 9570 PSME3 partof FPLX 000394 Proteasome -HGNC 9571 PSMF1 partof FPLX 000394 Proteasome -HGNC 10845 SEM1 partof FPLX 000394 Proteasome -HGNC 12628 USP5 partof FPLX 000394 Proteasome -HGNC 2896 DLAT partof FPLX 000352 PDH -HGNC 2898 DLD partof FPLX 000352 PDH -HGNC 8806 PDHA1 partof FPLX 000352 PDH -HGNC 8807 PDHA2 partof FPLX 000352 PDH -HGNC 8808 PDHB partof FPLX 000352 PDH -HGNC 21350 PDHX partof FPLX 000352 PDH -HGNC 9969 RFC1 partof FPLX 000411 RFC -HGNC 9970 RFC2 partof FPLX 000411 RFC -HGNC 9971 RFC3 partof FPLX 000411 RFC -HGNC 9972 RFC4 partof FPLX 000411 RFC -HGNC 9973 RFC5 partof FPLX 000411 RFC -HGNC 17264 POLR1A partof FPLX 000416 RNApo_I -HGNC 20454 POLR1B partof FPLX 000416 RNApo_I -HGNC 20194 POLR1C partof FPLX 000416 RNApo_I -HGNC 20422 POLR1D partof FPLX 000416 RNApo_I -HGNC 9187 POLR2A partof FPLX 000417 RNApo_II -HGNC 9188 POLR2B partof FPLX 000417 RNApo_II -HGNC 9189 POLR2C partof FPLX 000417 RNApo_II -HGNC 9191 POLR2D partof FPLX 000417 RNApo_II -HGNC 9192 POLR2E partof FPLX 000417 RNApo_II -HGNC 9193 POLR2F partof FPLX 000417 RNApo_II -HGNC 9194 POLR2G partof FPLX 000417 RNApo_II -HGNC 9195 POLR2H partof FPLX 000417 RNApo_II -HGNC 9196 POLR2I partof FPLX 000417 RNApo_II -HGNC 9197 POLR2J partof FPLX 000417 RNApo_II -HGNC 23208 POLR2J2 partof FPLX 000417 RNApo_II -HGNC 9198 POLR2K partof FPLX 000417 RNApo_II -HGNC 9199 POLR2L partof FPLX 000417 RNApo_II -HGNC 3535 F2 partof FPLX 000469 Thrombin_antithrombin -HGNC 775 SERPINC1 partof FPLX 000469 Thrombin_antithrombin -HGNC 11532 TAF1A partof FPLX 000471 TIF_IB -HGNC 11533 TAF1B partof FPLX 000471 TIF_IB -HGNC 11534 TAF1C partof FPLX 000471 TIF_IB -HGNC 11588 TBP partof FPLX 000471 TIF_IB -HGNC 18752 MAPKAP1 partof FPLX 000294 mTORC2 -HGNC 3942 MTOR partof FPLX 000294 mTORC2 -HGNC 28611 RICTOR partof FPLX 000294 mTORC2 -HGNC 24825 MLST8 partof FPLX 000294 mTORC2 -HGNC 3942 MTOR partof FPLX 000293 mTORC1 -HGNC 30287 RPTOR partof FPLX 000293 mTORC1 -HGNC 11998 TP53 isa FPLX 000327 p53_family -HGNC 15979 TP63 isa FPLX 000327 p53_family -HGNC 12003 TP73 isa FPLX 000327 p53_family -HGNC 9585 PTCH1 isa FPLX 000333 Patched -HGNC 9586 PTCH2 isa FPLX 000333 Patched -HGNC 11943 TNNC1 isa FPLX 000478 Troponin_C -HGNC 11944 TNNC2 isa FPLX 000478 Troponin_C -HGNC 11945 TNNI1 isa FPLX 000479 Troponin_I -HGNC 11946 TNNI2 isa FPLX 000479 Troponin_I -HGNC 11947 TNNI3 isa FPLX 000479 Troponin_I -HGNC 11948 TNNT1 isa FPLX 000480 Troponin_T -HGNC 11949 TNNT2 isa FPLX 000480 Troponin_T -HGNC 11950 TNNT3 isa FPLX 000480 Troponin_T -FPLX 000478 Troponin_C partof FPLX 000477 Troponin -FPLX 000479 Troponin_I partof FPLX 000477 Troponin -FPLX 000480 Troponin_T partof FPLX 000477 Troponin -HGNC 811 ATP2A1 isa FPLX 000430 SERCA -HGNC 812 ATP2A2 isa FPLX 000430 SERCA -HGNC 813 ATP2A3 isa FPLX 000430 SERCA -HGNC 8014 YBX1 isa FPLX 000498 YBX -HGNC 17948 YBX2 isa FPLX 000498 YBX -HGNC 2428 YBX3 isa FPLX 000498 YBX -HGNC 1925 CHEK1 isa FPLX 000098 CHEK -HGNC 16627 CHEK2 isa FPLX 000098 CHEK -HGNC 270 PARP1 isa FPLX 000331 PARP -HGNC 272 PARP2 isa FPLX 000331 PARP -HGNC 273 PARP3 isa FPLX 000331 PARP -HGNC 271 PARP4 isa FPLX 000331 PARP -HGNC 26921 PARP6 isa FPLX 000331 PARP -HGNC 26124 PARP8 isa FPLX 000331 PARP -HGNC 24118 PARP9 isa FPLX 000331 PARP -HGNC 25895 PARP10 isa FPLX 000331 PARP -HGNC 1186 PARP11 isa FPLX 000331 PARP -HGNC 21919 PARP12 isa FPLX 000331 PARP -HGNC 29232 PARP14 isa FPLX 000331 PARP -HGNC 26876 PARP15 isa FPLX 000331 PARP -HGNC 26040 PARP16 isa FPLX 000331 PARP -HGNC 11941 TNKS isa FPLX 000331 PARP -HGNC 15677 TNKS2 isa FPLX 000331 PARP -HGNC 23696 TIPARP isa FPLX 000331 PARP -HGNC 7781 NFE2L1 isa FPLX 000310 NFE -HGNC 7782 NFE2L2 isa FPLX 000310 NFE -HGNC 7783 NFE2L3 isa FPLX 000310 NFE -HGNC 1784 CDKN1A isa FPLX 000095 CDKN1 -HGNC 1785 CDKN1B isa FPLX 000095 CDKN1 -HGNC 1786 CDKN1C isa FPLX 000095 CDKN1 -HGNC 1787 CDKN2A isa FPLX 000096 CDKN2 -HGNC 1788 CDKN2B isa FPLX 000096 CDKN2 -HGNC 1789 CDKN2C isa FPLX 000096 CDKN2 -HGNC 1790 CDKN2D isa FPLX 000096 CDKN2 -FPLX 000095 CDKN1 isa FPLX 000094 CDKN -FPLX 000096 CDKN2 isa FPLX 000094 CDKN -HGNC 1791 CDKN3 isa FPLX 000094 CDKN -HGNC 678 ARHGDIA isa FPLX 000415 RhoGDI -HGNC 679 ARHGDIB isa FPLX 000415 RhoGDI -HGNC 680 ARHGDIG isa FPLX 000415 RhoGDI -HGNC 10289 RPA1 partof FPLX 000421 RPA -HGNC 10290 RPA2 partof FPLX 000421 RPA -HGNC 10291 RPA3 partof FPLX 000421 RPA -HGNC 12027 TRA partof FPLX 000461 TCR -HGNC 12155 TRB partof FPLX 000461 TCR -HGNC 12252 TRD partof FPLX 000461 TCR -HGNC 12271 TRG partof FPLX 000461 TCR -HGNC 10249 ROBO1 isa FPLX 000418 ROBO -HGNC 10250 ROBO2 isa FPLX 000418 ROBO -HGNC 13433 ROBO3 isa FPLX 000418 ROBO -HGNC 11714 TEAD1 isa FPLX 000462 TEAD -HGNC 11715 TEAD2 isa FPLX 000462 TEAD -HGNC 11716 TEAD3 isa FPLX 000462 TEAD -HGNC 11717 TEAD4 isa FPLX 000462 TEAD -HGNC 16807 SMURF1 isa FPLX 000445 SMURF -HGNC 16809 SMURF2 isa FPLX 000445 SMURF -HGNC 3166 LPAR1 isa FPLX 000277 LPAR -HGNC 3168 LPAR2 isa FPLX 000277 LPAR -HGNC 14298 LPAR3 isa FPLX 000277 LPAR -HGNC 1044 BGN isa FPLX 000436 SLRP_1 -HGNC 2705 DCN isa FPLX 000436 SLRP_1 -HGNC 14872 ASPN isa FPLX 000436 SLRP_1 -HGNC 3154 ECM2 isa FPLX 000436 SLRP_1 -HGNC 3774 FMOD isa FPLX 000437 SLRP_2 -HGNC 6724 LUM isa FPLX 000437 SLRP_2 -HGNC 9357 PRELP isa FPLX 000437 SLRP_2 -HGNC 6309 KERA isa FPLX 000437 SLRP_2 -HGNC 8134 OMD isa FPLX 000437 SLRP_2 -HGNC 3053 EPYC isa FPLX 000438 SLRP_3 -HGNC 8158 OPTC isa FPLX 000438 SLRP_3 -HGNC 8126 OGN isa FPLX 000438 SLRP_3 -HGNC 1909 CHAD isa FPLX 000439 SLRP_4 -HGNC 8082 NYX isa FPLX 000439 SLRP_4 -HGNC 28850 TSKU isa FPLX 000439 SLRP_4 -HGNC 23174 PODN isa FPLX 000440 SLRP_5 -HGNC 26275 PODNL1 isa FPLX 000440 SLRP_5 -FPLX 000436 SLRP_1 isa FPLX 000435 SLRP -FPLX 000437 SLRP_2 isa FPLX 000435 SLRP -FPLX 000438 SLRP_3 isa FPLX 000435 SLRP -FPLX 000439 SLRP_4 isa FPLX 000435 SLRP -FPLX 000440 SLRP_5 isa FPLX 000435 SLRP -HGNC 8986 PIM1 isa FPLX 000362 PIM -HGNC 8987 PIM2 isa FPLX 000362 PIM -HGNC 19310 PIM3 isa FPLX 000362 PIM -HGNC 4579 GRIK1 isa FPLX 000269 Kainate_family -HGNC 4580 GRIK2 isa FPLX 000269 Kainate_family -HGNC 4581 GRIK3 isa FPLX 000269 Kainate_family -HGNC 4582 GRIK4 isa FPLX 000269 Kainate_family -HGNC 4583 GRIK5 isa FPLX 000269 Kainate_family -HGNC 8008 NRXN1 isa FPLX 000308 Neurexins -HGNC 8009 NRXN2 isa FPLX 000308 Neurexins -HGNC 8010 NRXN3 isa FPLX 000308 Neurexins -HGNC 6008 IL2RA partof FPLX 000255 IL2R -HGNC 6009 IL2RB partof FPLX 000255 IL2R -HGNC 6010 IL2RG partof FPLX 000255 IL2R -HGNC 5978 IL15RA partof FPLX 000254 IL15R -HGNC 6009 IL2RB partof FPLX 000254 IL15R -HGNC 6010 IL2RG partof FPLX 000254 IL15R -HGNC 14275 MRPL1 partof FPLX 000290 MRPL -HGNC 14056 MRPL2 partof FPLX 000290 MRPL -HGNC 10379 MRPL3 partof FPLX 000290 MRPL -HGNC 14276 MRPL4 partof FPLX 000290 MRPL -HGNC 14277 MRPL9 partof FPLX 000290 MRPL -HGNC 14055 MRPL10 partof FPLX 000290 MRPL -HGNC 14042 MRPL11 partof FPLX 000290 MRPL -HGNC 10378 MRPL12 partof FPLX 000290 MRPL -HGNC 14278 MRPL13 partof FPLX 000290 MRPL -HGNC 14279 MRPL14 partof FPLX 000290 MRPL -HGNC 14054 MRPL15 partof FPLX 000290 MRPL -HGNC 14476 MRPL16 partof FPLX 000290 MRPL -HGNC 14053 MRPL17 partof FPLX 000290 MRPL -HGNC 14477 MRPL18 partof FPLX 000290 MRPL -HGNC 14052 MRPL19 partof FPLX 000290 MRPL -HGNC 14478 MRPL20 partof FPLX 000290 MRPL -HGNC 14479 MRPL21 partof FPLX 000290 MRPL -HGNC 14480 MRPL22 partof FPLX 000290 MRPL -HGNC 10322 MRPL23 partof FPLX 000290 MRPL -HGNC 14037 MRPL24 partof FPLX 000290 MRPL -HGNC 14483 MRPL27 partof FPLX 000290 MRPL -HGNC 14484 MRPL28 partof FPLX 000290 MRPL -HGNC 14036 MRPL30 partof FPLX 000290 MRPL -HGNC 14035 MRPL32 partof FPLX 000290 MRPL -HGNC 14487 MRPL33 partof FPLX 000290 MRPL -HGNC 14488 MRPL34 partof FPLX 000290 MRPL -HGNC 14489 MRPL35 partof FPLX 000290 MRPL -HGNC 14490 MRPL36 partof FPLX 000290 MRPL -HGNC 14034 MRPL37 partof FPLX 000290 MRPL -HGNC 14033 MRPL38 partof FPLX 000290 MRPL -HGNC 14027 MRPL39 partof FPLX 000290 MRPL -HGNC 14491 MRPL40 partof FPLX 000290 MRPL -HGNC 14492 MRPL41 partof FPLX 000290 MRPL -HGNC 14493 MRPL42 partof FPLX 000290 MRPL -HGNC 14517 MRPL43 partof FPLX 000290 MRPL -HGNC 16650 MRPL44 partof FPLX 000290 MRPL -HGNC 16651 MRPL45 partof FPLX 000290 MRPL -HGNC 1192 MRPL46 partof FPLX 000290 MRPL -HGNC 16652 MRPL47 partof FPLX 000290 MRPL -HGNC 16653 MRPL48 partof FPLX 000290 MRPL -HGNC 1176 MRPL49 partof FPLX 000290 MRPL -HGNC 16654 MRPL50 partof FPLX 000290 MRPL -HGNC 14044 MRPL51 partof FPLX 000290 MRPL -HGNC 16655 MRPL52 partof FPLX 000290 MRPL -HGNC 16684 MRPL53 partof FPLX 000290 MRPL -HGNC 16685 MRPL54 partof FPLX 000290 MRPL -HGNC 16686 MRPL55 partof FPLX 000290 MRPL -HGNC 14514 MRPL57 partof FPLX 000290 MRPL -HGNC 14495 MRPS2 partof FPLX 000289 MRPS -HGNC 14498 MRPS5 partof FPLX 000289 MRPS -HGNC 14051 MRPS6 partof FPLX 000289 MRPS -HGNC 14499 MRPS7 partof FPLX 000289 MRPS -HGNC 14501 MRPS9 partof FPLX 000289 MRPS -HGNC 14502 MRPS10 partof FPLX 000289 MRPS -HGNC 14050 MRPS11 partof FPLX 000289 MRPS -HGNC 10380 MRPS12 partof FPLX 000289 MRPS -HGNC 14049 MRPS14 partof FPLX 000289 MRPS -HGNC 14504 MRPS15 partof FPLX 000289 MRPS -HGNC 14048 MRPS16 partof FPLX 000289 MRPS -HGNC 14047 MRPS17 partof FPLX 000289 MRPS -HGNC 14515 MRPS18A partof FPLX 000289 MRPS -HGNC 14516 MRPS18B partof FPLX 000289 MRPS -HGNC 16633 MRPS18C partof FPLX 000289 MRPS -HGNC 14046 MRPS21 partof FPLX 000289 MRPS -HGNC 14508 MRPS22 partof FPLX 000289 MRPS -HGNC 14509 MRPS23 partof FPLX 000289 MRPS -HGNC 14510 MRPS24 partof FPLX 000289 MRPS -HGNC 14511 MRPS25 partof FPLX 000289 MRPS -HGNC 14045 MRPS26 partof FPLX 000289 MRPS -HGNC 14512 MRPS27 partof FPLX 000289 MRPS -HGNC 14513 MRPS28 partof FPLX 000289 MRPS -HGNC 2673 DAP3 partof FPLX 000289 MRPS -HGNC 8769 MRPS30 partof FPLX 000289 MRPS -HGNC 16632 MRPS31 partof FPLX 000289 MRPS -HGNC 16634 MRPS33 partof FPLX 000289 MRPS -HGNC 16618 MRPS34 partof FPLX 000289 MRPS -HGNC 16635 MRPS35 partof FPLX 000289 MRPS -HGNC 16631 MRPS36 partof FPLX 000289 MRPS -FPLX 000289 MRPS partof FPLX 000288 Mitochondrial_Ribosome -FPLX 000290 MRPL partof FPLX 000288 Mitochondrial_Ribosome -HGNC 7939 NPPA isa FPLX 000304 Natriuretic_peptide -HGNC 7940 NPPB isa FPLX 000304 Natriuretic_peptide -HGNC 7941 NPPC isa FPLX 000304 Natriuretic_peptide -HGNC 7455 MT-ND1 partof FPLX 000499 ETC_complex_I_core -HGNC 7456 MT-ND2 partof FPLX 000499 ETC_complex_I_core -HGNC 7458 MT-ND3 partof FPLX 000499 ETC_complex_I_core -HGNC 7459 MT-ND4 partof FPLX 000499 ETC_complex_I_core -HGNC 7460 MT-ND4L partof FPLX 000499 ETC_complex_I_core -HGNC 7461 MT-ND5 partof FPLX 000499 ETC_complex_I_core -HGNC 7462 MT-ND6 partof FPLX 000499 ETC_complex_I_core -HGNC 7707 NDUFS1 partof FPLX 000499 ETC_complex_I_core -HGNC 7708 NDUFS2 partof FPLX 000499 ETC_complex_I_core -HGNC 7710 NDUFS3 partof FPLX 000499 ETC_complex_I_core -HGNC 7714 NDUFS7 partof FPLX 000499 ETC_complex_I_core -HGNC 7715 NDUFS8 partof FPLX 000499 ETC_complex_I_core -HGNC 7716 NDUFV1 partof FPLX 000499 ETC_complex_I_core -HGNC 7717 NDUFV2 partof FPLX 000499 ETC_complex_I_core -HGNC 7694 NDUFAB1 partof FPLX 000500 ETC_complex_I_supernumerary -HGNC 7683 NDUFA1 partof FPLX 000500 ETC_complex_I_supernumerary -HGNC 7685 NDUFA2 partof FPLX 000500 ETC_complex_I_supernumerary -HGNC 7686 NDUFA3 partof FPLX 000500 ETC_complex_I_supernumerary -HGNC 7688 NDUFA5 partof FPLX 000500 ETC_complex_I_supernumerary -HGNC 7690 NDUFA6 partof FPLX 000500 ETC_complex_I_supernumerary -HGNC 7691 NDUFA7 partof FPLX 000500 ETC_complex_I_supernumerary -HGNC 7692 NDUFA8 partof FPLX 000500 ETC_complex_I_supernumerary -HGNC 7693 NDUFA9 partof FPLX 000500 ETC_complex_I_supernumerary -HGNC 7684 NDUFA10 partof FPLX 000500 ETC_complex_I_supernumerary -HGNC 20371 NDUFA11 partof FPLX 000500 ETC_complex_I_supernumerary -HGNC 23987 NDUFA12 partof FPLX 000500 ETC_complex_I_supernumerary -HGNC 17194 NDUFA13 partof FPLX 000500 ETC_complex_I_supernumerary -HGNC 7695 NDUFB1 partof FPLX 000500 ETC_complex_I_supernumerary -HGNC 7697 NDUFB2 partof FPLX 000500 ETC_complex_I_supernumerary -HGNC 7698 NDUFB3 partof FPLX 000500 ETC_complex_I_supernumerary -HGNC 7699 NDUFB4 partof FPLX 000500 ETC_complex_I_supernumerary -HGNC 7700 NDUFB5 partof FPLX 000500 ETC_complex_I_supernumerary -HGNC 7701 NDUFB6 partof FPLX 000500 ETC_complex_I_supernumerary -HGNC 7702 NDUFB7 partof FPLX 000500 ETC_complex_I_supernumerary -HGNC 7703 NDUFB8 partof FPLX 000500 ETC_complex_I_supernumerary -HGNC 7704 NDUFB9 partof FPLX 000500 ETC_complex_I_supernumerary -HGNC 7696 NDUFB10 partof FPLX 000500 ETC_complex_I_supernumerary -HGNC 20372 NDUFB11 partof FPLX 000500 ETC_complex_I_supernumerary -HGNC 7705 NDUFC1 partof FPLX 000500 ETC_complex_I_supernumerary -HGNC 7706 NDUFC2 partof FPLX 000500 ETC_complex_I_supernumerary -HGNC 7711 NDUFS4 partof FPLX 000500 ETC_complex_I_supernumerary -HGNC 7712 NDUFS5 partof FPLX 000500 ETC_complex_I_supernumerary -HGNC 7713 NDUFS6 partof FPLX 000500 ETC_complex_I_supernumerary -HGNC 7719 NDUFV3 partof FPLX 000500 ETC_complex_I_supernumerary -FPLX 000499 ETC_complex_I_core partof FPLX 000501 ETC_complex_I -FPLX 000500 ETC_complex_I_supernumerary partof FPLX 000501 ETC_complex_I -HGNC 10680 SDHA partof FPLX 000502 ETC_complex_II -HGNC 10681 SDHB partof FPLX 000502 ETC_complex_II -HGNC 10682 SDHC partof FPLX 000502 ETC_complex_II -HGNC 10683 SDHD partof FPLX 000502 ETC_complex_II -HGNC 2579 CYC1 partof FPLX 000503 ETC_complex_III -HGNC 7427 MT-CYB partof FPLX 000503 ETC_complex_III -HGNC 12582 UQCRB partof FPLX 000503 ETC_complex_III -HGNC 12585 UQCRC1 partof FPLX 000503 ETC_complex_III -HGNC 12586 UQCRC2 partof FPLX 000503 ETC_complex_III -HGNC 12587 UQCRFS1 partof FPLX 000503 ETC_complex_III -HGNC 12590 UQCRH partof FPLX 000503 ETC_complex_III -HGNC 29594 UQCRQ partof FPLX 000503 ETC_complex_III -HGNC 30863 UQCR10 partof FPLX 000503 ETC_complex_III -HGNC 30862 UQCR11 partof FPLX 000503 ETC_complex_III -HGNC 2265 COX4I1 partof FPLX 000504 ETC_complex_IV -HGNC 16232 COX4I2 partof FPLX 000504 ETC_complex_IV -HGNC 2267 COX5A partof FPLX 000504 ETC_complex_IV -HGNC 2269 COX5B partof FPLX 000504 ETC_complex_IV -HGNC 2277 COX6A1 partof FPLX 000504 ETC_complex_IV -HGNC 2279 COX6A2 partof FPLX 000504 ETC_complex_IV -HGNC 2280 COX6B1 partof FPLX 000504 ETC_complex_IV -HGNC 24380 COX6B2 partof FPLX 000504 ETC_complex_IV -HGNC 2285 COX6C partof FPLX 000504 ETC_complex_IV -HGNC 2287 COX7A1 partof FPLX 000504 ETC_complex_IV -HGNC 2288 COX7A2 partof FPLX 000504 ETC_complex_IV -HGNC 2291 COX7B partof FPLX 000504 ETC_complex_IV -HGNC 24381 COX7B2 partof FPLX 000504 ETC_complex_IV -HGNC 2292 COX7C partof FPLX 000504 ETC_complex_IV -HGNC 2294 COX8A partof FPLX 000504 ETC_complex_IV -HGNC 24382 COX8C partof FPLX 000504 ETC_complex_IV -HGNC 7419 MT-CO1 partof FPLX 000504 ETC_complex_IV -HGNC 7421 MT-CO2 partof FPLX 000504 ETC_complex_IV -HGNC 7422 MT-CO3 partof FPLX 000504 ETC_complex_IV -HGNC 823 ATP5F1A partof FPLX 000060 ATP_synthase -HGNC 830 ATP5F1B partof FPLX 000060 ATP_synthase -HGNC 833 ATP5F1C partof FPLX 000060 ATP_synthase -HGNC 837 ATP5F1D partof FPLX 000060 ATP_synthase -HGNC 838 ATP5F1E partof FPLX 000060 ATP_synthase -HGNC 30889 ATP5MD partof FPLX 000060 ATP_synthase -HGNC 846 ATP5ME partof FPLX 000060 ATP_synthase -HGNC 848 ATP5MF partof FPLX 000060 ATP_synthase -HGNC 14247 ATP5MG partof FPLX 000060 ATP_synthase -HGNC 1188 ATP5MPL partof FPLX 000060 ATP_synthase -HGNC 7414 MT-ATP6 partof FPLX 000060 ATP_synthase -HGNC 7415 MT-ATP8 partof FPLX 000060 ATP_synthase -HGNC 840 ATP5PB partof FPLX 000060 ATP_synthase -HGNC 845 ATP5PD partof FPLX 000060 ATP_synthase -HGNC 847 ATP5PF partof FPLX 000060 ATP_synthase -HGNC 850 ATP5PO partof FPLX 000060 ATP_synthase -HGNC 871 ATP5IF1 partof FPLX 000060 ATP_synthase -HGNC 841 ATP5MC1 isa FPLX 000059 ATP5G -HGNC 842 ATP5MC2 isa FPLX 000059 ATP5G -HGNC 843 ATP5MC3 isa FPLX 000059 ATP5G -FPLX 000059 ATP5G partof FPLX 000060 ATP_synthase -HGNC 7393 MT1A isa FPLX 000292 Metallothionein -HGNC 7394 MT1B isa FPLX 000292 Metallothionein -HGNC 7395 MT1CP isa FPLX 000292 Metallothionein -HGNC 7396 MT1DP isa FPLX 000292 Metallothionein -HGNC 7397 MT1E isa FPLX 000292 Metallothionein -HGNC 7398 MT1F isa FPLX 000292 Metallothionein -HGNC 7399 MT1G isa FPLX 000292 Metallothionein -HGNC 7400 MT1H isa FPLX 000292 Metallothionein -HGNC 31864 MT1HL1 isa FPLX 000292 Metallothionein -HGNC 7401 MT1IP isa FPLX 000292 Metallothionein -HGNC 7402 MT1JP isa FPLX 000292 Metallothionein -HGNC 7404 MT1L isa FPLX 000292 Metallothionein -HGNC 14296 MT1M isa FPLX 000292 Metallothionein -HGNC 23681 MT1P1 isa FPLX 000292 Metallothionein -HGNC 16120 MT1P3 isa FPLX 000292 Metallothionein -HGNC 7405 MT1X isa FPLX 000292 Metallothionein -HGNC 7406 MT2A isa FPLX 000292 Metallothionein -HGNC 7408 MT3 isa FPLX 000292 Metallothionein -HGNC 18705 MT4 isa FPLX 000292 Metallothionein -HGNC 660 TRIM23 isa FPLX 000053 ARF_GTPase_family -HGNC 652 ARF1 isa FPLX 000053 ARF_GTPase_family -HGNC 654 ARF3 isa FPLX 000053 ARF_GTPase_family -HGNC 655 ARF4 isa FPLX 000053 ARF_GTPase_family -HGNC 658 ARF5 isa FPLX 000053 ARF_GTPase_family -HGNC 659 ARF6 isa FPLX 000053 ARF_GTPase_family -HGNC 692 ARL1 isa FPLX 000053 ARF_GTPase_family -HGNC 693 ARL2 isa FPLX 000053 ARF_GTPase_family -HGNC 694 ARL3 isa FPLX 000053 ARF_GTPase_family -HGNC 695 ARL4A isa FPLX 000053 ARF_GTPase_family -HGNC 698 ARL4C isa FPLX 000053 ARF_GTPase_family -HGNC 656 ARL4D isa FPLX 000053 ARF_GTPase_family -HGNC 696 ARL5A isa FPLX 000053 ARF_GTPase_family -HGNC 23052 ARL5B isa FPLX 000053 ARF_GTPase_family -HGNC 31111 ARL5C isa FPLX 000053 ARF_GTPase_family -HGNC 13210 ARL6 isa FPLX 000053 ARF_GTPase_family -HGNC 25192 ARL8A isa FPLX 000053 ARF_GTPase_family -HGNC 25564 ARL8B isa FPLX 000053 ARF_GTPase_family -HGNC 23592 ARL9 isa FPLX 000053 ARF_GTPase_family -HGNC 22042 ARL10 isa FPLX 000053 ARF_GTPase_family -HGNC 24046 ARL11 isa FPLX 000053 ARF_GTPase_family -HGNC 31709 ARL13A isa FPLX 000053 ARF_GTPase_family -HGNC 25419 ARL13B isa FPLX 000053 ARF_GTPase_family -HGNC 22974 ARL14 isa FPLX 000053 ARF_GTPase_family -HGNC 25945 ARL15 isa FPLX 000053 ARF_GTPase_family -HGNC 27902 ARL16 isa FPLX 000053 ARF_GTPase_family -HGNC 24096 ARL17A isa FPLX 000053 ARF_GTPase_family -HGNC 32387 ARL17B isa FPLX 000053 ARF_GTPase_family -HGNC 662 ARFRP1 isa FPLX 000053 ARF_GTPase_family -HGNC 10534 SAR1A isa FPLX 000053 ARF_GTPase_family -HGNC 10535 SAR1B isa FPLX 000053 ARF_GTPase_family -FPLX 000002 A4GALT_family isa FPLX 000198 Glycosyltransferase -FPLX 000026 ALG10 isa FPLX 000198 Glycosyltransferase -FPLX 000027 ALG1_family isa FPLX 000198 Glycosyltransferase -FPLX 000028 ALG3_family isa FPLX 000198 Glycosyltransferase -FPLX 000029 ALG6_family isa FPLX 000198 Glycosyltransferase -FPLX 000030 ALG13_family isa FPLX 000198 Glycosyltransferase -FPLX 000063 B3GAT isa FPLX 000198 Glycosyltransferase -FPLX 000065 Beta_3_4_GTF isa FPLX 000198 Glycosyltransferase -FPLX 000112 COLGALT isa FPLX 000198 Glycosyltransferase -FPLX 000165 EXT isa FPLX 000198 Glycosyltransferase -FPLX 000176 FUT isa FPLX 000198 Glycosyltransferase -FPLX 000180 GALNT isa FPLX 000198 Glycosyltransferase -FPLX 000185 GCNT isa FPLX 000198 Glycosyltransferase -FPLX 000199 GTF_family_2 isa FPLX 000198 Glycosyltransferase -FPLX 000200 GTF_family_6 isa FPLX 000198 Glycosyltransferase -FPLX 000201 GTF_family_8 isa FPLX 000198 Glycosyltransferase -FPLX 000202 GTF_family_29 isa FPLX 000198 Glycosyltransferase -FPLX 000203 GTF_family_90 isa FPLX 000198 Glycosyltransferase -FPLX 000287 MGAT isa FPLX 000198 Glycosyltransferase -FPLX 000322 OGT_family isa FPLX 000198 Glycosyltransferase -FPLX 000396 PYG isa FPLX 000198 Glycosyltransferase -FPLX 000455 STT3 isa FPLX 000198 Glycosyltransferase -FPLX 000491 UGCG isa FPLX 000198 Glycosyltransferase -FPLX 000492 UGT isa FPLX 000198 Glycosyltransferase -FPLX 000493 UGGT isa FPLX 000198 Glycosyltransferase -HGNC 23162 ALG10 isa FPLX 000026 ALG10 -HGNC 31088 ALG10B isa FPLX 000026 ALG10 -HGNC 23157 ALG6 isa FPLX 000029 ALG6_family -HGNC 23161 ALG8 isa FPLX 000029 ALG6_family -HGNC 18149 A4GALT isa FPLX 000002 A4GALT_family -HGNC 17968 A4GNT isa FPLX 000002 A4GALT_family -HGNC 921 B3GAT1 isa FPLX 000063 B3GAT -HGNC 922 B3GAT2 isa FPLX 000063 B3GAT -HGNC 923 B3GAT3 isa FPLX 000063 B3GAT -HGNC 918 B3GALNT1 isa FPLX 000065 Beta_3_4_GTF -HGNC 28596 B3GALNT2 isa FPLX 000065 Beta_3_4_GTF -HGNC 20207 B3GLCT isa FPLX 000065 Beta_3_4_GTF -HGNC 916 B3GALT1 isa FPLX 000065 Beta_3_4_GTF -HGNC 917 B3GALT2 isa FPLX 000065 Beta_3_4_GTF -HGNC 919 B3GALT4 isa FPLX 000065 Beta_3_4_GTF -HGNC 920 B3GALT5 isa FPLX 000065 Beta_3_4_GTF -HGNC 17978 B3GALT6 isa FPLX 000065 Beta_3_4_GTF -HGNC 15629 B3GNT2 isa FPLX 000065 Beta_3_4_GTF -HGNC 13528 B3GNT3 isa FPLX 000065 Beta_3_4_GTF -HGNC 15683 B3GNT4 isa FPLX 000065 Beta_3_4_GTF -HGNC 15684 B3GNT5 isa FPLX 000065 Beta_3_4_GTF -HGNC 24141 B3GNT6 isa FPLX 000065 Beta_3_4_GTF -HGNC 18811 B3GNT7 isa FPLX 000065 Beta_3_4_GTF -HGNC 24139 B3GNT8 isa FPLX 000065 Beta_3_4_GTF -HGNC 28714 B3GNT9 isa FPLX 000065 Beta_3_4_GTF -HGNC 24291 CHPF isa FPLX 000065 Beta_3_4_GTF -HGNC 29270 CHPF2 isa FPLX 000065 Beta_3_4_GTF -HGNC 17198 CHSY1 isa FPLX 000065 Beta_3_4_GTF -HGNC 24293 CHSY3 isa FPLX 000065 Beta_3_4_GTF -HGNC 24337 C1GALT1 isa FPLX 000065 Beta_3_4_GTF -HGNC 6560 LFNG isa FPLX 000065 Beta_3_4_GTF -HGNC 7038 MFNG isa FPLX 000065 Beta_3_4_GTF -HGNC 9974 RFNG isa FPLX 000065 Beta_3_4_GTF -HGNC 4117 B4GALNT1 isa FPLX 000065 Beta_3_4_GTF -HGNC 24136 B4GALNT2 isa FPLX 000065 Beta_3_4_GTF -HGNC 24137 B4GALNT3 isa FPLX 000065 Beta_3_4_GTF -HGNC 26315 B4GALNT4 isa FPLX 000065 Beta_3_4_GTF -HGNC 924 B4GALT1 isa FPLX 000065 Beta_3_4_GTF -HGNC 925 B4GALT2 isa FPLX 000065 Beta_3_4_GTF -HGNC 926 B4GALT3 isa FPLX 000065 Beta_3_4_GTF -HGNC 927 B4GALT4 isa FPLX 000065 Beta_3_4_GTF -HGNC 928 B4GALT5 isa FPLX 000065 Beta_3_4_GTF -HGNC 929 B4GALT6 isa FPLX 000065 Beta_3_4_GTF -HGNC 930 B4GALT7 isa FPLX 000065 Beta_3_4_GTF -HGNC 24290 CSGALNACT1 isa FPLX 000065 Beta_3_4_GTF -HGNC 24292 CSGALNACT2 isa FPLX 000065 Beta_3_4_GTF -HGNC 26182 COLGALT1 isa FPLX 000112 COLGALT -HGNC 16790 COLGALT2 isa FPLX 000112 COLGALT -HGNC 23056 ALG3 isa FPLX 000028 ALG3_family -HGNC 15672 ALG9 isa FPLX 000028 ALG3_family -HGNC 19358 ALG12 isa FPLX 000028 ALG3_family -HGNC 8959 PIGB isa FPLX 000028 ALG3_family -HGNC 18858 PIGM isa FPLX 000028 ALG3_family -HGNC 26031 PIGV isa FPLX 000028 ALG3_family -HGNC 30596 PIGZ isa FPLX 000028 ALG3_family -HGNC 9202 POMT1 isa FPLX 000028 ALG3_family -HGNC 19743 POMT2 isa FPLX 000028 ALG3_family -HGNC 3515 EXTL1 isa FPLX 000165 EXT -HGNC 3516 EXTL2 isa FPLX 000165 EXT -HGNC 3518 EXTL3 isa FPLX 000165 EXT -HGNC 3512 EXT1 isa FPLX 000165 EXT -HGNC 3513 EXT2 isa FPLX 000165 EXT -HGNC 4012 FUT1 isa FPLX 000176 FUT -HGNC 4013 FUT2 isa FPLX 000176 FUT -HGNC 4014 FUT3 isa FPLX 000176 FUT -HGNC 4015 FUT4 isa FPLX 000176 FUT -HGNC 4016 FUT5 isa FPLX 000176 FUT -HGNC 4017 FUT6 isa FPLX 000176 FUT -HGNC 4018 FUT7 isa FPLX 000176 FUT -HGNC 4019 FUT8 isa FPLX 000176 FUT -HGNC 4020 FUT9 isa FPLX 000176 FUT -HGNC 19234 FUT10 isa FPLX 000176 FUT -HGNC 19233 FUT11 isa FPLX 000176 FUT -HGNC 14988 POFUT1 isa FPLX 000176 FUT -HGNC 14683 POFUT2 isa FPLX 000176 FUT -HGNC 4203 GCNT1 isa FPLX 000185 GCNT -HGNC 4204 GCNT2 isa FPLX 000185 GCNT -HGNC 4205 GCNT3 isa FPLX 000185 GCNT -HGNC 17973 GCNT4 isa FPLX 000185 GCNT -HGNC 16099 GCNT7 isa FPLX 000185 GCNT -HGNC 15516 XYLT1 isa FPLX 000185 GCNT -HGNC 15517 XYLT2 isa FPLX 000185 GCNT -HGNC 9723 PYGB isa FPLX 000396 PYG -HGNC 9725 PYGL isa FPLX 000396 PYG -HGNC 9726 PYGM isa FPLX 000396 PYG -HGNC 20266 ALG5 isa FPLX 000199 GTF_family_2 -HGNC 21727 B3GNTL1 isa FPLX 000199 GTF_family_2 -HGNC 3005 DPM1 isa FPLX 000199 GTF_family_2 -HGNC 4818 HAS1 isa FPLX 000199 GTF_family_2 -HGNC 4819 HAS2 isa FPLX 000199 GTF_family_2 -HGNC 4820 HAS3 isa FPLX 000199 GTF_family_2 -HGNC 79 ABO isa FPLX 000200 GTF_family_6 -HGNC 30005 A3GALT2 isa FPLX 000200 GTF_family_6 -HGNC 20460 GBGT1 isa FPLX 000200 GTF_family_6 -HGNC 23671 GLT6D1 isa FPLX 000200 GTF_family_6 -HGNC 24870 GLT8D1 isa FPLX 000201 GTF_family_8 -HGNC 24890 GLT8D2 isa FPLX 000201 GTF_family_8 -HGNC 27482 GXYLT1 isa FPLX 000201 GTF_family_8 -HGNC 33383 GXYLT2 isa FPLX 000201 GTF_family_8 -HGNC 4699 GYG1 isa FPLX 000201 GTF_family_8 -HGNC 4700 GYG2 isa FPLX 000201 GTF_family_8 -HGNC 6511 LARGE1 isa FPLX 000201 GTF_family_8 -HGNC 16522 LARGE2 isa FPLX 000201 GTF_family_8 -HGNC 13530 RXYLT1 isa FPLX 000201 GTF_family_8 -HGNC 26639 XXYLT1 isa FPLX 000201 GTF_family_8 -HGNC 19350 POGLUT2 isa FPLX 000203 GTF_family_90 -HGNC 28496 POGLUT3 isa FPLX 000203 GTF_family_90 -HGNC 22954 POGLUT1 isa FPLX 000203 GTF_family_90 -HGNC 18294 ALG1 isa FPLX 000027 ALG1_family -HGNC 33721 ALG1L isa FPLX 000027 ALG1_family -HGNC 37258 ALG1L2 isa FPLX 000027 ALG1_family -HGNC 23159 ALG2 isa FPLX 000027 ALG1_family -HGNC 32456 ALG11 isa FPLX 000027 ALG1_family -HGNC 26483 GLT1D1 isa FPLX 000027 ALG1_family -HGNC 20887 GTDC1 isa FPLX 000027 ALG1_family -HGNC 4706 GYS1 isa FPLX 000027 ALG1_family -HGNC 4707 GYS2 isa FPLX 000027 ALG1_family -HGNC 8957 PIGA isa FPLX 000027 ALG1_family -HGNC 7044 MGAT1 isa FPLX 000287 MGAT -HGNC 7045 MGAT2 isa FPLX 000287 MGAT -HGNC 7046 MGAT3 isa FPLX 000287 MGAT -HGNC 7047 MGAT4A isa FPLX 000287 MGAT -HGNC 7048 MGAT4B isa FPLX 000287 MGAT -HGNC 30871 MGAT4C isa FPLX 000287 MGAT -HGNC 43619 MGAT4D isa FPLX 000287 MGAT -HGNC 7049 MGAT5 isa FPLX 000287 MGAT -HGNC 24140 MGAT5B isa FPLX 000287 MGAT -HGNC 28526 EOGT isa FPLX 000322 OGT_family -HGNC 8127 OGT isa FPLX 000322 OGT_family -HGNC 19139 POMGNT1 isa FPLX 000322 OGT_family -HGNC 25902 POMGNT2 isa FPLX 000322 OGT_family -HGNC 21725 GALNTL5 isa FPLX 000180 GALNT -HGNC 33844 GALNTL6 isa FPLX 000180 GALNT -HGNC 4123 GALNT1 isa FPLX 000180 GALNT -HGNC 4124 GALNT2 isa FPLX 000180 GALNT -HGNC 4125 GALNT3 isa FPLX 000180 GALNT -HGNC 4126 GALNT4 isa FPLX 000180 GALNT -HGNC 4127 GALNT5 isa FPLX 000180 GALNT -HGNC 4128 GALNT6 isa FPLX 000180 GALNT -HGNC 4129 GALNT7 isa FPLX 000180 GALNT -HGNC 4130 GALNT8 isa FPLX 000180 GALNT -HGNC 4131 GALNT9 isa FPLX 000180 GALNT -HGNC 19873 GALNT10 isa FPLX 000180 GALNT -HGNC 19875 GALNT11 isa FPLX 000180 GALNT -HGNC 19877 GALNT12 isa FPLX 000180 GALNT -HGNC 23242 GALNT13 isa FPLX 000180 GALNT -HGNC 22946 GALNT14 isa FPLX 000180 GALNT -HGNC 21531 GALNT15 isa FPLX 000180 GALNT -HGNC 23233 GALNT16 isa FPLX 000180 GALNT -HGNC 30488 GALNT18 isa FPLX 000180 GALNT -HGNC 16347 GALNT17 isa FPLX 000180 GALNT -HGNC 10862 ST3GAL1 isa FPLX 000202 GTF_family_29 -HGNC 10863 ST3GAL2 isa FPLX 000202 GTF_family_29 -HGNC 10866 ST3GAL3 isa FPLX 000202 GTF_family_29 -HGNC 10864 ST3GAL4 isa FPLX 000202 GTF_family_29 -HGNC 10872 ST3GAL5 isa FPLX 000202 GTF_family_29 -HGNC 18080 ST3GAL6 isa FPLX 000202 GTF_family_29 -HGNC 23614 ST6GALNAC1 isa FPLX 000202 GTF_family_29 -HGNC 10867 ST6GALNAC2 isa FPLX 000202 GTF_family_29 -HGNC 19343 ST6GALNAC3 isa FPLX 000202 GTF_family_29 -HGNC 17846 ST6GALNAC4 isa FPLX 000202 GTF_family_29 -HGNC 19342 ST6GALNAC5 isa FPLX 000202 GTF_family_29 -HGNC 23364 ST6GALNAC6 isa FPLX 000202 GTF_family_29 -HGNC 10860 ST6GAL1 isa FPLX 000202 GTF_family_29 -HGNC 10861 ST6GAL2 isa FPLX 000202 GTF_family_29 -HGNC 10869 ST8SIA1 isa FPLX 000202 GTF_family_29 -HGNC 10870 ST8SIA2 isa FPLX 000202 GTF_family_29 -HGNC 14269 ST8SIA3 isa FPLX 000202 GTF_family_29 -HGNC 10871 ST8SIA4 isa FPLX 000202 GTF_family_29 -HGNC 17827 ST8SIA5 isa FPLX 000202 GTF_family_29 -HGNC 23317 ST8SIA6 isa FPLX 000202 GTF_family_29 -HGNC 6172 STT3A isa FPLX 000455 STT3 -HGNC 30611 STT3B isa FPLX 000455 STT3 -HGNC 12524 UGCG isa FPLX 000491 UGCG -HGNC 15663 UGGT1 isa FPLX 000493 UGGT -HGNC 15664 UGGT2 isa FPLX 000493 UGGT -HGNC 12529 UGT1A isa FPLX 000492 UGT -HGNC 12530 UGT1A1 isa FPLX 000492 UGT -HGNC 12534 UGT1A2P isa FPLX 000492 UGT -HGNC 12535 UGT1A3 isa FPLX 000492 UGT -HGNC 12536 UGT1A4 isa FPLX 000492 UGT -HGNC 12537 UGT1A5 isa FPLX 000492 UGT -HGNC 12538 UGT1A6 isa FPLX 000492 UGT -HGNC 12539 UGT1A7 isa FPLX 000492 UGT -HGNC 12540 UGT1A8 isa FPLX 000492 UGT -HGNC 12541 UGT1A9 isa FPLX 000492 UGT -HGNC 12531 UGT1A10 isa FPLX 000492 UGT -HGNC 12532 UGT1A11P isa FPLX 000492 UGT -HGNC 12533 UGT1A12P isa FPLX 000492 UGT -HGNC 32191 UGT1A13P isa FPLX 000492 UGT -HGNC 12542 UGT2A1 isa FPLX 000492 UGT -HGNC 28183 UGT2A2 isa FPLX 000492 UGT -HGNC 28528 UGT2A3 isa FPLX 000492 UGT -HGNC 12553 UGT2B4 isa FPLX 000492 UGT -HGNC 12554 UGT2B7 isa FPLX 000492 UGT -HGNC 12544 UGT2B10 isa FPLX 000492 UGT -HGNC 12545 UGT2B11 isa FPLX 000492 UGT -HGNC 12546 UGT2B15 isa FPLX 000492 UGT -HGNC 12547 UGT2B17 isa FPLX 000492 UGT -HGNC 12548 UGT2B24P isa FPLX 000492 UGT -HGNC 12549 UGT2B25P isa FPLX 000492 UGT -HGNC 12550 UGT2B26P isa FPLX 000492 UGT -HGNC 12551 UGT2B27P isa FPLX 000492 UGT -HGNC 13479 UGT2B28 isa FPLX 000492 UGT -HGNC 12552 UGT2B29P isa FPLX 000492 UGT -HGNC 26625 UGT3A1 isa FPLX 000492 UGT -HGNC 27266 UGT3A2 isa FPLX 000492 UGT -HGNC 12555 UGT8 isa FPLX 000492 UGT -HGNC 30881 ALG13 isa FPLX 000030 ALG13_family -HGNC 28287 ALG14 isa FPLX 000030 ALG13_family -HGNC 9855 RAP1A isa FPLX 000401 RAP1 -HGNC 9857 RAP1B isa FPLX 000401 RAP1 -HGNC 11142 SIK1 isa FPLX 000433 SIK -HGNC 21680 SIK2 isa FPLX 000433 SIK -HGNC 29165 SIK3 isa FPLX 000433 SIK -HGNC 3091 DYRK1A isa FPLX 000146 DYRK -HGNC 3092 DYRK1B isa FPLX 000146 DYRK -HGNC 3093 DYRK2 isa FPLX 000146 DYRK -HGNC 3094 DYRK3 isa FPLX 000146 DYRK -HGNC 3095 DYRK4 isa FPLX 000146 DYRK -HGNC 25174 HAUS1 partof FPLX 000061 Augmin -HGNC 25530 HAUS2 partof FPLX 000061 Augmin -HGNC 28719 HAUS3 partof FPLX 000061 Augmin -HGNC 20163 HAUS4 partof FPLX 000061 Augmin -HGNC 29130 HAUS5 partof FPLX 000061 Augmin -HGNC 25948 HAUS6 partof FPLX 000061 Augmin -HGNC 32979 HAUS7 partof FPLX 000061 Augmin -HGNC 30532 HAUS8 partof FPLX 000061 Augmin -HGNC 16062 CRTC1 isa FPLX 000123 CRTC -HGNC 27301 CRTC2 isa FPLX 000123 CRTC -HGNC 26148 CRTC3 isa FPLX 000123 CRTC From fff88490b8f127058ef75eda8fd532bb0512b61e Mon Sep 17 00:00:00 2001 From: Charles Tapley Hoyt Date: Sun, 21 Jul 2019 18:56:51 +0200 Subject: [PATCH 13/19] Fix filename and update README --- README.md | 10 +++++----- famplex/check_references.py | 10 +++++----- famplex/constants.py | 8 ++++---- famplex/export/export_belns.py | 4 ++-- famplex/export/export_obo.py | 10 +++++----- famplex/export/export_relations_graph.py | 4 ++-- famplex/export/hgnc_ids.py | 6 +++--- famplex/reorganize_old_resources.py | 12 ++++++------ 8 files changed, 32 insertions(+), 32 deletions(-) diff --git a/README.md b/README.md index 15939d8d4..c9ce4320e 100644 --- a/README.md +++ b/README.md @@ -32,7 +32,7 @@ the FamPlex namespace. * ```entities.csv```. A registry of the families and complexes defined in the FamPlex namespace. -* ```descriptions.tsv```. Descriptions and citations of some entities. Contains +* ```descriptions.csv```. Descriptions and citations of some entities. Contains three columns: the FamPlex name, comma separated reference CURIEs, and a textual description. @@ -65,7 +65,7 @@ relationships, including sub-families (families within families) and complexes consisting of families of related subunits (e.g., PI3K, NF-kB). The ```relations.csv``` file consists of five columns: (1) the namespace for -the subject (e.g., ```HGNC``` for gene names, ```UP``` for Uniprot, or +the subject (e.g., ```HGNC``` for gene names, ```UP``` for UniProt, or ```FPLX``` for the FamPlex namespace), (2) the identifier for the subject, (3) the relationship (```isa``` or ```partof```), (4) the namespace for the object, and (5) the identifier for the object. @@ -91,10 +91,10 @@ cancer. Entities are grounded to the following databases: -* Genes/proteins: [Uniprot](http://www.uniprot.org) +* Genes/proteins: [UniProt](http://www.uniprot.org) * Chemicals: [PubChem](https://pubchem.ncbi.nlm.nih.gov/), - [CHEBI](https://www.ebi.ac.uk/chebi/), and [HMDB](http://www.hmdb.ca/) (for + [ChEBI](https://www.ebi.ac.uk/chebi/), and [HMDB](http://www.hmdb.ca/) (for metabolites) * Biological processes: [GO](http://geneontology.org/) and @@ -103,7 +103,7 @@ Entities are grounded to the following databases: * Protein families and named complexes: grounded to entities defined within the FamPlex repository in the ```entities.csv``` and ```relations.csv``` files, and to identifiers in [PFAM](http://pfam.xfam.org/) - and [Interpro](https://www.ebi.ac.uk/interpro/) when possible. + and [InterPro](https://www.ebi.ac.uk/interpro/) when possible. ## Gene prefixes diff --git a/famplex/check_references.py b/famplex/check_references.py index 68722a40b..085ba4687 100644 --- a/famplex/check_references.py +++ b/famplex/check_references.py @@ -6,7 +6,7 @@ import sys from collections import Counter, defaultdict -from famplex.constants import ENTITIES_TSV_PATH, EQUIVALENCES_TSV_PATH, GROUNDING_MAP_TSV_PATH, RELATIONS_TSV_PATH +from famplex.constants import ENTITIES_PATH, EQUIVALENCES_PATH, GROUNDING_MAP_PATH, RELATIONS_PATH def load_csv(path): @@ -111,10 +111,10 @@ def check_duplicates(entries, entry_label): def main(): signal_error = False - entities = load_entity_list(ENTITIES_TSV_PATH) - relationships = load_relationships(RELATIONS_TSV_PATH) - equivalences = load_equivalences(EQUIVALENCES_TSV_PATH) - gm, gm_tuples = load_grounding_map(GROUNDING_MAP_TSV_PATH) + entities = load_entity_list(ENTITIES_PATH) + relationships = load_relationships(RELATIONS_PATH) + equivalences = load_equivalences(EQUIVALENCES_PATH) + gm, gm_tuples = load_grounding_map(GROUNDING_MAP_PATH) em = { eid: ename diff --git a/famplex/constants.py b/famplex/constants.py index 68a7cdb72..50a007d44 100644 --- a/famplex/constants.py +++ b/famplex/constants.py @@ -7,10 +7,10 @@ HERE = os.path.abspath(os.path.dirname(__file__)) RESOURCES = os.path.join(HERE, 'resources') -ENTITIES_TSV_PATH = os.path.join(RESOURCES, 'entities.csv') -EQUIVALENCES_TSV_PATH = os.path.join(RESOURCES, 'equivalences.csv') -GROUNDING_MAP_TSV_PATH = os.path.join(RESOURCES, 'grounding_map.csv') -RELATIONS_TSV_PATH = os.path.join(RESOURCES, 'relations.csv') +ENTITIES_PATH = os.path.join(RESOURCES, 'entities.csv') +EQUIVALENCES_PATH = os.path.join(RESOURCES, 'equivalences.csv') +GROUNDING_MAP_PATH = os.path.join(RESOURCES, 'grounding_map.csv') +RELATIONS_PATH = os.path.join(RESOURCES, 'relations.csv') METADATA_PATH = os.path.join(RESOURCES, 'metadata.json') EXPORT_DIR = os.path.abspath(os.path.join(HERE, os.pardir, 'export')) diff --git a/famplex/export/export_belns.py b/famplex/export/export_belns.py index 8b3f00cd0..b2f970b88 100644 --- a/famplex/export/export_belns.py +++ b/famplex/export/export_belns.py @@ -8,13 +8,13 @@ from bel_resources import write_namespace from bel_resources.constants import NAMESPACE_DOMAIN_GENE -from famplex.constants import ENTITIES_TSV_PATH, EXPORT_DIR +from famplex.constants import ENTITIES_PATH, EXPORT_DIR DEFAULT_BELNS_PATH = os.path.join(EXPORT_DIR, 'famplex.belns') def _get_entities(): - with open(ENTITIES_TSV_PATH) as file: + with open(ENTITIES_PATH) as file: reader = csv.reader( file, delimiter=',', diff --git a/famplex/export/export_obo.py b/famplex/export/export_obo.py index e6bfb7c64..3f4688dbe 100644 --- a/famplex/export/export_obo.py +++ b/famplex/export/export_obo.py @@ -4,7 +4,7 @@ import os from famplex.constants import ( - ENTITIES_TSV_PATH, EQUIVALENCES_TSV_PATH, EXPORT_DIR, GROUNDING_MAP_TSV_PATH, RELATIONS_TSV_PATH, + ENTITIES_PATH, EQUIVALENCES_PATH, EXPORT_DIR, GROUNDING_MAP_PATH, RELATIONS_PATH, ) DEFAULT_OBO_PATH = os.path.join(EXPORT_DIR, 'famplex.obo') @@ -89,7 +89,7 @@ def __str__(self): def get_obo_terms(): obo_terms = [ROOT_OBO_TERM] - with open(ENTITIES_TSV_PATH) as fh: + with open(ENTITIES_PATH) as fh: reader = csv.reader( fh, delimiter=',', @@ -106,7 +106,7 @@ def get_obo_terms(): for fplx_id, fplx_name, description, references in reader } - with open(EQUIVALENCES_TSV_PATH, 'r') as fh: + with open(EQUIVALENCES_PATH, 'r') as fh: reader = csv.reader( fh, delimiter=',', @@ -118,7 +118,7 @@ def get_obo_terms(): for xref_db, xref_id, fplx_id, _ in reader: equivalences[fplx_id].append((xref_db, xref_id)) - with open(GROUNDING_MAP_TSV_PATH) as fh: + with open(GROUNDING_MAP_PATH) as fh: reader = csv.reader( fh, delimiter=',', @@ -131,7 +131,7 @@ def get_obo_terms(): if db == 'FPLX': textrefs[db_id].append(textref) - with open(RELATIONS_TSV_PATH) as fh: + with open(RELATIONS_PATH) as fh: rels = { entity: collections.OrderedDict( is_a=[], diff --git a/famplex/export/export_relations_graph.py b/famplex/export/export_relations_graph.py index 53d148128..380583c56 100644 --- a/famplex/export/export_relations_graph.py +++ b/famplex/export/export_relations_graph.py @@ -3,7 +3,7 @@ import pygraphviz as pgv -from famplex.constants import EXPORT_DIR, RELATIONS_TSV_PATH +from famplex.constants import EXPORT_DIR, RELATIONS_PATH DEFAULT_RELATIONS_GRAPH_PATH = os.path.join(EXPORT_DIR, 'relations_graph.pdf') @@ -29,7 +29,7 @@ def node_label(db, db_id, name): def main(output_file=DEFAULT_RELATIONS_GRAPH_PATH): graph = pgv.AGraph(name='relations', directed=True, rankdir='LR') - with open(RELATIONS_TSV_PATH) as file: + with open(RELATIONS_PATH) as file: reader = csv.reader( file, delimiter=',', diff --git a/famplex/export/hgnc_ids.py b/famplex/export/hgnc_ids.py index 680a203dc..e7b387a43 100644 --- a/famplex/export/hgnc_ids.py +++ b/famplex/export/hgnc_ids.py @@ -8,7 +8,7 @@ import csv import os -from famplex.constants import EXPORT_DIR, GROUNDING_MAP_TSV_PATH, RELATIONS_TSV_PATH +from famplex.constants import EXPORT_DIR, GROUNDING_MAP_PATH, RELATIONS_PATH from indra.databases import hgnc_client HERE = os.path.dirname(os.path.abspath(__file__)) @@ -18,7 +18,7 @@ def main(): hgnc_symbols = set() # Gather all HGNC symbols from relations.csv - with open(RELATIONS_TSV_PATH) as f: + with open(RELATIONS_PATH) as f: for ns1, id1, n1, rel, ns2, id2, n2 in csv.reader(f, delimiter='\t'): if ns1 == 'HGNC': hgnc_symbols.add(n1) @@ -26,7 +26,7 @@ def main(): hgnc_symbols.add(n2) # Gather all HGNC symbols from grounding_map.csv - with open(GROUNDING_MAP_TSV_PATH) as f: + with open(GROUNDING_MAP_PATH) as f: for text, db, db_id, db_name in csv.reader(f, delimiter='\t'): if db == 'HGNC': hgnc_symbols.add(db_name) diff --git a/famplex/reorganize_old_resources.py b/famplex/reorganize_old_resources.py index 397cc09cd..d25877532 100644 --- a/famplex/reorganize_old_resources.py +++ b/famplex/reorganize_old_resources.py @@ -11,8 +11,8 @@ from typing import Tuple from famplex.constants import ( - ENTITIES_TSV_PATH, EQUIVALENCES_TSV_PATH, GROUNDING_MAP_TSV_PATH, METADATA_PATH, - RELATIONS_TSV_PATH, + ENTITIES_PATH, EQUIVALENCES_PATH, GROUNDING_MAP_PATH, METADATA_PATH, + RELATIONS_PATH, ) from indra.databases import chebi_client, go_client, hgnc_client, mesh_client, mirbase_client, uniprot_client @@ -75,7 +75,7 @@ def get_id_label(db: str, db_id: str) -> Tuple[str, str]: for fplx_name, references, description in reader } - with open('entities.csv') as in_file, open(ENTITIES_TSV_PATH, 'w') as out_file: + with open('entities.csv') as in_file, open(ENTITIES_PATH, 'w') as out_file: writer = csv.writer( out_file, delimiter=',', @@ -94,7 +94,7 @@ def get_id_label(db: str, db_id: str) -> Tuple[str, str]: ','.join(references) if references is not None else '', )) - with open('equivalences.csv') as in_file, open(EQUIVALENCES_TSV_PATH, 'w') as out_file: + with open('equivalences.csv') as in_file, open(EQUIVALENCES_PATH, 'w') as out_file: # print('xref_db', 'xref_id', 'fplx_id', 'fplx_name', sep='\t', file=out_file) reader = csv.reader( in_file, @@ -119,7 +119,7 @@ def get_id_label(db: str, db_id: str) -> Tuple[str, str]: )) groundings_unlabelled = set() - with open('grounding_map.csv') as in_file, open(GROUNDING_MAP_TSV_PATH, 'w') as out_file: + with open('grounding_map.csv') as in_file, open(GROUNDING_MAP_PATH, 'w') as out_file: reader = csv.reader( in_file, delimiter=',', @@ -154,7 +154,7 @@ def get_id_label(db: str, db_id: str) -> Tuple[str, str]: print(f'{xref_db:>{s}s} unlabelled {count}') relations_unlabelled = set() - with open('relations.csv') as in_file, open(RELATIONS_TSV_PATH, 'w') as out_file: + with open('relations.csv') as in_file, open(RELATIONS_PATH, 'w') as out_file: # print('sub_db', 'sub_id', 'sub_name', 'rel', # 'obj_db', 'obj_id', 'obj_name', sep='\t', file=out_file) From 06a6dc7241f9cb90a6cb46fe3678701502de70af Mon Sep 17 00:00:00 2001 From: Charles Tapley Hoyt Date: Sun, 21 Jul 2019 19:03:25 +0200 Subject: [PATCH 14/19] Add check for text with multiple groundings to the same database --- famplex/check_references.py | 25 ++++++++++++++++--------- 1 file changed, 16 insertions(+), 9 deletions(-) diff --git a/famplex/check_references.py b/famplex/check_references.py index 085ba4687..88bfd7bb7 100644 --- a/famplex/check_references.py +++ b/famplex/check_references.py @@ -26,9 +26,11 @@ def load_grounding_map(filename): gm_rows = load_csv(filename) check_rows(gm_rows, 4, filename) g_map = defaultdict(dict) + e_map = defaultdict(list) for text, db, db_id, _ in gm_rows: g_map[text][db] = db_id - return g_map, gm_rows + e_map[text, db].append(db_id) + return g_map, gm_rows, e_map def check_file_rows(filename, row_length): @@ -114,11 +116,11 @@ def main(): entities = load_entity_list(ENTITIES_PATH) relationships = load_relationships(RELATIONS_PATH) equivalences = load_equivalences(EQUIVALENCES_PATH) - gm, gm_tuples = load_grounding_map(GROUNDING_MAP_PATH) + gm, gm_tuples, entity_to_texts = load_grounding_map(GROUNDING_MAP_PATH) - em = { - eid: ename - for eid, ename, *_ in entities + famplex_id_to_name = { + fplx_id: fplx_name + for fplx_id, fplx_name, *_ in entities } for entries, entry_label in ((entities, 'entities'), @@ -128,12 +130,17 @@ def main(): if check_duplicates(entries, entry_label): signal_error = True + print("-- Checking for doubly grounded text in grounding map --") + for (text, db), db_ids in entity_to_texts.items(): + if len(db_ids) > 1: + print(f'ERROR "{text}" has multiple {db} groundings: {", ".join(db_ids)}') + print("-- Checking for undeclared FamPlex IDs in grounding map --") # Look through grounding map and find all instances with an FPLX db key entities_missing_gm = [] for text, db_refs in gm.items(): for db_key, db_id in db_refs.items(): - if db_key == 'FPLX' and db_id not in em: + if db_key == 'FPLX' and db_id not in famplex_id_to_name: entities_missing_gm.append(db_id) print("ERROR: ID %s referenced in grounding map " "is not in entities list." % db_id) @@ -162,7 +169,7 @@ def main(): entities_missing_rel = [] for subj, rel, obj in relationships: for term_ns, term_id, term_name in (subj, obj): - if term_ns == 'FPLX' and term_id not in em: + if term_ns == 'FPLX' and term_id not in famplex_id_to_name: entities_missing_rel.append(term_id) print("ERROR: ID %s referenced in relations " "is not in entities list." % term_id) @@ -243,7 +250,7 @@ def main(): print("-- Checking for FamPlexes whose relationships are undefined --") # Check the relationships for consistency with entities rel_missing_entities = [] - for ent in em: + for ent in famplex_id_to_name: found = False for (subj_ns, subj_id, _), rel, (obj_ns, obj_id, _) in relationships: if subj_ns == 'FPLX' and subj_id == ent: @@ -260,7 +267,7 @@ def main(): print("-- Checking for non-existent FamPlexes in equivalences --") entities_missing_eq = [] for eq_ns, eq_id, fplx_id, _ in equivalences: - if fplx_id not in em: + if fplx_id not in famplex_id_to_name: signal_error = True entities_missing_eq.append(fplx_id) print("ERROR: ID %s referenced in equivalences " From 0d643638d03fee26eca7d6fabaa0b66e82713077 Mon Sep 17 00:00:00 2001 From: Charles Tapley Hoyt Date: Sun, 21 Jul 2019 19:05:00 +0200 Subject: [PATCH 15/19] Update formatting of output [skip ci] --- famplex/check_references.py | 3 ++- 1 file changed, 2 insertions(+), 1 deletion(-) diff --git a/famplex/check_references.py b/famplex/check_references.py index 88bfd7bb7..36d5f5c22 100644 --- a/famplex/check_references.py +++ b/famplex/check_references.py @@ -133,7 +133,8 @@ def main(): print("-- Checking for doubly grounded text in grounding map --") for (text, db), db_ids in entity_to_texts.items(): if len(db_ids) > 1: - print(f'ERROR "{text}" has multiple {db} groundings: {", ".join(db_ids)}') + print(f'WARNING "{text}" has multiple {db} groundings: {", ".join(db_ids)}') + print() print("-- Checking for undeclared FamPlex IDs in grounding map --") # Look through grounding map and find all instances with an FPLX db key From 3e945f4bf7b947fb7d6dbe1b3d5225c874ede2e1 Mon Sep 17 00:00:00 2001 From: Charles Tapley Hoyt Date: Sun, 21 Jul 2019 19:15:05 +0200 Subject: [PATCH 16/19] Check for existence of cache files --- import/interpro_mappings.py | 3 ++- import/reactome_mappings.py | 3 ++- 2 files changed, 4 insertions(+), 2 deletions(-) diff --git a/import/interpro_mappings.py b/import/interpro_mappings.py index 3e32c0f67..d3ca6fd30 100644 --- a/import/interpro_mappings.py +++ b/import/interpro_mappings.py @@ -1,4 +1,5 @@ import json +import os from collections import defaultdict from indra.statements import Agent from indra.databases import hgnc_client @@ -9,7 +10,7 @@ import common def get_ip_families_for_be(be_up_ids, cache_file=None): - if cache_file is not None: + if cache_file is not None and os.path.exists(cache_file): with open(cache_file, 'rt') as f: ipfs = [line.strip() for line in f.readlines()] return ipfs diff --git a/import/reactome_mappings.py b/import/reactome_mappings.py index 770368c44..b175be236 100644 --- a/import/reactome_mappings.py +++ b/import/reactome_mappings.py @@ -1,5 +1,6 @@ import csv import json +import os import requests from functools import lru_cache from collections import defaultdict @@ -136,7 +137,7 @@ def get_all_parents(up_id): def get_rx_family_members(up_ids, cache_file=None): """Get dictionary mapping Reactome sets/complexes to member Uniprot IDs.""" # Check to see if we're loading from a cache - if cache_file is not None: + if cache_file is not None and os.path.exists(cache_file): with open(cache_file, 'rt') as f: rx_family_members = json.load(f) return rx_family_members From d9c7775316395592d0bca2516bd386ea3791bf8a Mon Sep 17 00:00:00 2001 From: Charles Tapley Hoyt Date: Sun, 21 Jul 2019 19:16:29 +0200 Subject: [PATCH 17/19] Update hgnc_ids.py --- famplex/export/hgnc_ids.py | 18 ++++++++++++++++-- 1 file changed, 16 insertions(+), 2 deletions(-) diff --git a/famplex/export/hgnc_ids.py b/famplex/export/hgnc_ids.py index e7b387a43..545aaedbe 100644 --- a/famplex/export/hgnc_ids.py +++ b/famplex/export/hgnc_ids.py @@ -19,7 +19,14 @@ def main(): hgnc_symbols = set() # Gather all HGNC symbols from relations.csv with open(RELATIONS_PATH) as f: - for ns1, id1, n1, rel, ns2, id2, n2 in csv.reader(f, delimiter='\t'): + reader = csv.reader( + f, + delimiter=',', + lineterminator='\r\n', + quoting=csv.QUOTE_MINIMAL, + quotechar='"', + ) + for ns1, id1, n1, rel, ns2, id2, n2 in reader: if ns1 == 'HGNC': hgnc_symbols.add(n1) if ns2 == 'HGNC': @@ -27,7 +34,14 @@ def main(): # Gather all HGNC symbols from grounding_map.csv with open(GROUNDING_MAP_PATH) as f: - for text, db, db_id, db_name in csv.reader(f, delimiter='\t'): + reader = csv.reader( + f, + delimiter=',', + lineterminator='\r\n', + quoting=csv.QUOTE_MINIMAL, + quotechar='"', + ) + for text, db, db_id, db_name in reader: if db == 'HGNC': hgnc_symbols.add(db_name) From 864baefcd89f1f7401cf8eeefda25d2769767bb7 Mon Sep 17 00:00:00 2001 From: Charles Tapley Hoyt Date: Mon, 22 Jul 2019 00:08:57 +0200 Subject: [PATCH 18/19] Improve output --- famplex/check_references.py | 114 +++++++++++++++++------------------- 1 file changed, 53 insertions(+), 61 deletions(-) diff --git a/famplex/check_references.py b/famplex/check_references.py index 36d5f5c22..e8b95947a 100644 --- a/famplex/check_references.py +++ b/famplex/check_references.py @@ -27,9 +27,9 @@ def load_grounding_map(filename): check_rows(gm_rows, 4, filename) g_map = defaultdict(dict) e_map = defaultdict(list) - for text, db, db_id, _ in gm_rows: + for text, db, db_id, db_name in gm_rows: g_map[text][db] = db_id - e_map[text, db].append(db_id) + e_map[text, db].append((db_id, db_name)) return g_map, gm_rows, e_map @@ -133,10 +133,13 @@ def main(): print("-- Checking for doubly grounded text in grounding map --") for (text, db), db_ids in entity_to_texts.items(): if len(db_ids) > 1: + db_ids = [ + f'{db}:{db_id} ! {db_name}' + for db_id, db_name in db_ids + ] print(f'WARNING "{text}" has multiple {db} groundings: {", ".join(db_ids)}') - print() - print("-- Checking for undeclared FamPlex IDs in grounding map --") + print("\n-- Checking for undeclared FamPlex IDs in grounding map --") # Look through grounding map and find all instances with an FPLX db key entities_missing_gm = [] for text, db_refs in gm.items(): @@ -147,8 +150,7 @@ def main(): "is not in entities list." % db_id) signal_error = True - print() - print("-- Checking for CHEBI/PUBCHEM IDs--") + print("\n-- Checking for CHEBI/PUBCHEM IDs--") chebi_id_missing = [] pubchem_id_missing = [] for text, db_refs in gm.items(): @@ -156,15 +158,14 @@ def main(): p_and_c = pubchem_and_chebi(db_refs) if p_and_c == 'chebi_missing': chebi_id_missing.append(db_refs['PUBCHEM']) - print("WARNING: %s has PubChem ID (pubchem.compound:%s) but no CHEBI ID." + print("WARNING: %s has PubChem ID (%s) but no CHEBI ID." % (text, db_refs['PUBCHEM'])) if p_and_c == 'pubchem_missing': pubchem_id_missing.append(db_refs['CHEBI']) print("WARNING: %s has ChEBI ID (%s) but no PUBCHEM ID." % (text, db_refs['CHEBI'])) - print() - print("-- Checking for undeclared FamPlex IDs in relationships file --") + print("\n-- Checking for undeclared FamPlex IDs in relationships file --") # Load the relationships # Check the relationships for consistency with entities entities_missing_rel = [] @@ -175,8 +176,8 @@ def main(): print("ERROR: ID %s referenced in relations " "is not in entities list." % term_id) signal_error = True - print() - print("-- Checking for valid namespaces in relations --") + + print("\n-- Checking for valid namespaces in relations --") for ix, (subj, rel, obj) in enumerate(relationships, start=1): for term_ns, term_id, term_name in (subj, obj): if term_ns not in ('FPLX', 'HGNC', 'UP'): @@ -187,9 +188,12 @@ def main(): # This check requires the indra package try: from indra.databases import hgnc_client - - print() - print("-- Checking for invalid HGNC IDs in relationships file --") + except ImportError as e: + print('\nHGNC check could not be performed because of import error') + print(e) + signal_error = True + else: + print("\n-- Checking for invalid HGNC IDs in relationships file --") for subj, rel, obj in relationships: for term_ns, term_id, term_name in (subj, obj): if term_ns == 'HGNC': @@ -202,18 +206,16 @@ def main(): print("ERROR: HGNC %s symbol out of sync." "%s should be %s" % term_id, term_name, lu_term_name) signal_error = True - except ImportError as e: - print('HGNC check could not be performed because of import error') - print(e) - signal_error = True - pass # This check requires the indra package try: from indra.databases import hgnc_client - - print() - print("-- Checking for invalid HGNC IDs in grounding map --") + except ImportError as e: + print('\nHGNC check could not be performed because of import error') + print(e) + signal_error = True + else: + print("\n-- Checking for invalid HGNC IDs in grounding map --") for text, db_refs in gm.items(): if db_refs is not None: for db_key, db_id in db_refs.items(): @@ -223,11 +225,6 @@ def main(): print("ERROR: ID %s in grounding map is " "not a valid HGNC ID." % db_id) signal_error = True - except ImportError: - print('HGNC check could not be performed because of import error') - print(e) - signal_error = True - pass # This check requires a ChEBI resource file to be available. You # can obtain it from here: ftp://ftp.ebi.ac.uk/pub/databases/ @@ -235,37 +232,32 @@ def main(): try: with open('chebi_compounds.tsv', 'rt') as fh: chebi_ids = [lin.split('\t')[2] for lin in fh.readlines()] - print() - print("-- Checking for invalid ChEBI IDs in grounding map --") - for text, db_refs in gm.items(): - if db_refs is not None: - for db_key, db_id in db_refs.items(): - if db_key == 'CHEBI': - if db_id not in chebi_ids: - print("ERROR: ID %s in grounding map is " - "not a valid CHEBI ID." % db_id) except IOError: - pass - - print() - print("-- Checking for FamPlexes whose relationships are undefined --") + print('\n ChEBI ID check could not be performed because of IO error') + print(e) + else: + print("\n-- Checking for invalid ChEBI IDs in grounding map --") + for text, db_refs in gm.items(): + if db_refs is None: + continue + for db_key, db_id in db_refs.items(): + if db_key != 'CHEBI': + continue + if db_id not in chebi_ids: + print("ERROR: ID %s in grounding map is " + "not a valid CHEBI ID." % db_id) + + print("\n-- Checking for FamPlexes whose relationships are undefined --") # Check the relationships for consistency with entities - rel_missing_entities = [] for ent in famplex_id_to_name: - found = False - for (subj_ns, subj_id, _), rel, (obj_ns, obj_id, _) in relationships: - if subj_ns == 'FPLX' and subj_id == ent: - found = True - break - if obj_ns == 'FPLX' and obj_id == ent: - found = True - break + found = any( + (s_ns == 'FPLX' and s_id == ent or o_ns == 'FPLX' and o_id == ent) + for (s_ns, s_id, _), rel, (o_ns, o_id, _) in relationships + ) if not found: - rel_missing_entities.append(ent) print("WARNING: ID %s has no known relations." % ent) - print() - print("-- Checking for non-existent FamPlexes in equivalences --") + print("\n-- Checking for non-existent FamPlexes in equivalences --") entities_missing_eq = [] for eq_ns, eq_id, fplx_id, _ in equivalences: if fplx_id not in famplex_id_to_name: @@ -273,11 +265,14 @@ def main(): entities_missing_eq.append(fplx_id) print("ERROR: ID %s referenced in equivalences " "is not in entities list." % fplx_id) - print() - print("-- Checking for duplicate equivalences --") + + print("\n-- Checking for duplicate equivalences --") equiv_counter = Counter(equivalences) - duplicate_eq = [item for item, count in equiv_counter.items() - if count > 1] + duplicate_eq = [ + item + for item, count in equiv_counter.items() + if count > 1 + ] if duplicate_eq: print("ERROR: Duplicate equivalences found:") for dup in duplicate_eq: @@ -293,8 +288,7 @@ def main(): else: logging.getLogger('requests').setLevel(logging.CRITICAL) logging.getLogger('urllib3').setLevel(logging.CRITICAL) - print() - print("-- Checking for invalid PUBCHEM CIDs in grounding map --") + print("\n-- Checking for invalid PUBCHEM CIDs in grounding map --") pubchem_url = 'https://pubchem.ncbi.nlm.nih.gov/rest/pug/compound/' + \ 'cid/%s/description/XML' @@ -310,9 +304,7 @@ def main(): print("ERROR: ID %s in grounding map is " "not a valid PUBCHEM ID." % db_id) - if signal_error: - sys.exit(1) - sys.exit(0) + sys.exit(1 if signal_error else 0) if __name__ == '__main__': From ee417e4b58bfe718370a1d34bf413a1e737a7387 Mon Sep 17 00:00:00 2001 From: Charles Tapley Hoyt Date: Mon, 22 Jul 2019 00:26:43 +0200 Subject: [PATCH 19/19] Refactor code for import Still can't run interpro, reactome, or signor successfully --- import/bel_grounding_map.py | 9 ++- import/common.py | 12 ++-- import/greek_letter_mappings.py | 8 ++- import/interpro_mappings.py | 65 +++++++++++++------- import/reactome_mappings.py | 106 +++++++++++++++++--------------- import/signor_mappings.py | 41 +++++++----- 6 files changed, 142 insertions(+), 99 deletions(-) diff --git a/import/bel_grounding_map.py b/import/bel_grounding_map.py index ba97de918..6083d2d87 100644 --- a/import/bel_grounding_map.py +++ b/import/bel_grounding_map.py @@ -1,6 +1,7 @@ -from common import * +from common import load_entity_list, load_equivalences, load_grounding_map -if __name__ == '__main__': + +def main(): equivalences = load_equivalences('../equivalences.csv') has_bel_mapping = set() for source_db, source_id, be_id in equivalences: @@ -40,3 +41,7 @@ bel_to_lookup = sorted(bel_counts.items(), key=lambda x: x[1], reverse=True) bel_to_lookup = [b for b in bel_to_lookup if b[1] > 0] + + +if __name__ == '__main__': + main() diff --git a/import/common.py b/import/common.py index 273ef29b4..e0ce6e0cd 100644 --- a/import/common.py +++ b/import/common.py @@ -1,13 +1,11 @@ -import re -import sys import csv -from indra.statements import Agent +import sys + from indra.databases import hgnc_client -from indra.databases import uniprot_client -from indra.tools.expand_families import Expander from indra.preassembler.hierarchy_manager import hierarchies +from indra.statements import Agent +from indra.tools.expand_families import Expander -import common def read_csv(fh, delimiter, quotechar): if sys.version_info.major < 3: @@ -63,7 +61,7 @@ def load_entity_list(filename): def get_child_map(): """Get dictionary mapping FPLX IDs to Uniprot IDs of all children.""" - entities = common.load_entity_list('../entities.csv') + entities = load_entity_list('../entities.csv') be_agents = [Agent(be_id, db_refs={'FPLX': be_id}) for be_id in entities] diff --git a/import/greek_letter_mappings.py b/import/greek_letter_mappings.py index 4c29d9e03..817d2dcdd 100644 --- a/import/greek_letter_mappings.py +++ b/import/greek_letter_mappings.py @@ -4,15 +4,17 @@ character, and add en entry to the grounding map for each of these if they aren't already in there""" -import os import csv +import os + from indra.resources.greek_alphabet import greek_alphabet # These are the characters that are spelled out and we want to map chars_to_map = ['alpha', 'beta', 'gamma', 'delta', 'epsilon', 'kappa', 'theta'] greek_reverse = {v: k for k, v in greek_alphabet.items()} -if __name__ == '__main__': + +def main(): path_this = os.path.dirname(os.path.abspath(__file__)) gm_file = os.path.join(path_this, os.pardir, 'grounding_map.csv') new_rows = [] @@ -53,3 +55,5 @@ csvwriter.writerow(row) +if __name__ == '__main__': + main() diff --git a/import/interpro_mappings.py b/import/interpro_mappings.py index d3ca6fd30..a2ed9d8a2 100644 --- a/import/interpro_mappings.py +++ b/import/interpro_mappings.py @@ -1,20 +1,19 @@ import json import os from collections import defaultdict -from indra.statements import Agent -from indra.databases import hgnc_client -from indra.tools.expand_families import Expander -from indra.preassembler.hierarchy_manager import hierarchies + +from common import get_child_map, jaccard_index, read_csv from indra.databases import uniprot_client -import common def get_ip_families_for_be(be_up_ids, cache_file=None): if cache_file is not None and os.path.exists(cache_file): with open(cache_file, 'rt') as f: ipfs = [line.strip() for line in f.readlines()] return ipfs + # If not cached, read from file + ip_families_for_be = set() with open('protein2ipr.dat', 'rt') as f: counter = 0 while True: @@ -30,9 +29,14 @@ def get_ip_families_for_be(be_up_ids, cache_file=None): ip_families_for_be.add(ip_id) counter += 1 + return ip_families_for_be + -def get_ip_family_members(ip_families_for_be, ip_datafile='protein2ipr.dat', - cache_file=None): +def get_ip_family_members( + ip_families_for_be, + ip_datafile='protein2ipr.dat', + cache_file=None, +): # Check if Interpro info is cached if cache_file is not None: with open(cache_file, 'rt') as f: @@ -52,8 +56,10 @@ def get_ip_family_members(ip_families_for_be, ip_datafile='protein2ipr.dat', if ip_id in ip_families_for_be and uniprot_client.is_human(up_id): ip_fam_info = ip_family_members.get(ip_id) if ip_fam_info is None: - ip_family_members[ip_id] = {'name': ip_name, - 'members': [up_id]} + ip_family_members[ip_id] = { + 'name': ip_name, + 'members': [up_id] + } else: ip_fam_info['members'].append(up_id) counter += 1 @@ -64,7 +70,7 @@ def get_ip_family_members(ip_families_for_be, ip_datafile='protein2ipr.dat', def load_uniprot(filename): with open(filename, 'rt') as f: - entries = common.read_csv(f, delimiter='\t', quotechar='"') + entries = read_csv(f, delimiter='\t', quotechar='"') up_ids = [row[0] for row in entries[1:]] return up_ids @@ -86,31 +92,44 @@ def get_mappings(be_child_map, ip_family_members, uniprot_ids, # Skip empty sets if not ip_set: continue - jacc = common.jaccard_index(be_set, ip_set) + jacc = jaccard_index(be_set, ip_set) if jacc >= jaccard_cutoff: - mapping = {'id': ip_id, 'name': ip_name, - 'members': list(ip_set), 'jaccardIndex': jacc, - 'equivalence': 'IP,%s,%s' % (ip_id, be_id)} + mapping = { + 'id': ip_id, 'name': ip_name, + 'members': list(ip_set), 'jaccardIndex': jacc, + 'equivalence': 'IP,%s,%s' % (ip_id, be_id) + } mappings[be_id].append(mapping) if be_id in mappings: mappings[be_id].sort(key=lambda d: d['jaccardIndex'], reverse=True) return mappings -if __name__ == '__main__': - be_child_map = common.get_child_map() +def main(): + be_child_map = get_child_map() be_up_ids = [up_id for child_list in be_child_map.values() - for up_id in child_list] + for up_id in child_list] - ip_families_for_be = get_ip_families_for_be(be_up_ids, - cache_file='ip_families_for_be.txt') - ip_family_members = get_ip_family_members(ip_families_for_be, - cache_file='ip_family_members.json') + ip_families_for_be = get_ip_families_for_be( + be_up_ids, + cache_file='ip_families_for_be.txt', + ) + ip_family_members = get_ip_family_members( + ip_families_for_be, + cache_file='ip_family_members.json', + ) up_ids = load_uniprot('uniprot_reviewed_human.tsv') - mappings = get_mappings(be_child_map, ip_family_members, up_ids, - jaccard_cutoff=1) + mappings = get_mappings( + be_child_map, + ip_family_members, + up_ids, + jaccard_cutoff=1, + ) for be_id, map_list in mappings.items(): for map_info in map_list: ip_id = map_info['id'] print("IP,%s,%s" % (ip_id, be_id)) + +if __name__ == '__main__': + main() diff --git a/import/reactome_mappings.py b/import/reactome_mappings.py index b175be236..569c588a6 100644 --- a/import/reactome_mappings.py +++ b/import/reactome_mappings.py @@ -1,24 +1,24 @@ -import csv import json import os -import requests -from functools import lru_cache from collections import defaultdict +from functools import lru_cache + +import requests -import common +from common import get_child_map, jaccard_index @lru_cache(10000) def rx_id_from_up_id(up_id): """Get the Reactome Stable ID for a given Uniprot ID.""" react_search_url = 'http://www.reactome.org/ContentService/search/query' - params = {'query': up_id, 'cluster': 'true', 'species':'Homo sapiens'} + params = {'query': up_id, 'cluster': 'true', 'species': 'Homo sapiens'} headers = {'Accept': 'application/json'} res = requests.get(react_search_url, headers=headers, params=params) if not res.status_code == 200: return None - json = res.json() - results = json.get('results') + res_json = res.json() + results = res_json.get('results') if not results: print('No results for %s' % up_id) return None @@ -54,16 +54,16 @@ def up_id_from_rx_id(reactome_id): @lru_cache(10000) def get_participants(reactome_id): - """Get Uniprot IDs of members of a Reactome DefinedSet or CandidateSet.""" + """Get UniProt IDs of members of a Reactome DefinedSet or CandidateSet.""" react_url = 'http://www.reactome.org/ContentService/data/event/' \ + reactome_id + '/participatingReferenceEntities' headers = {'Accept': 'application/json'} res = requests.get(react_url, headers=headers) if not res.status_code == 200: return [] - json = res.json() + res_json = res.json() up_ids = [] - for res in json: + for res in res_json: if not res.get('databaseName') == 'UniProt': continue up_id = res.get('identifier') @@ -74,16 +74,16 @@ def get_participants(reactome_id): @lru_cache(10000) def get_subunits(complex_id): - """Get Uniprot IDs of subunits of a Reactome Complex.""" + """Get UniProt IDs of subunits of a Reactome Complex.""" react_url = 'http://www.reactome.org/ContentService/data/complex/' \ + complex_id + '/subunits' headers = {'Accept': 'application/json'} res = requests.get(react_url, headers=headers) if not res.status_code == 200: return [] - json = res.json() + res_json = res.json() up_ids = [] - for subunit in json: + for subunit in res_json: subunit_rx_id = subunit.get('stId') if not subunit_rx_id: continue @@ -95,20 +95,19 @@ def get_subunits(complex_id): @lru_cache(10000) def _get_parents(stable_id): - """Recursively get all parents of a Reactome ID.""" + """Get all parents of a Reactome ID recursively.""" react_data_url = 'http://www.reactome.org/ContentService/data/entity/' + \ stable_id + '/componentOf' headers = {'Accept': 'application/json'} res = requests.get(react_data_url, headers=headers) if not res.status_code == 200: return [] - json = res.json() + res_json = res.json() names = [] stable_ids = [] schema_classes = [] - for parent_group in json: - if not parent_group.get('type') in \ - ['hasComponent', 'hasMember', 'hasCandidate']: + for parent_group in res_json: + if not parent_group.get('type') in ['hasComponent', 'hasMember', 'hasCandidate']: continue names += parent_group.get('names') stable_ids += parent_group.get('stIds') @@ -122,10 +121,10 @@ def _get_parents(stable_id): @lru_cache(10000) def get_all_parents(up_id): - """Get all parents for all Reactome IDs linked to a Uniprot ID.""" + """Get all parents for all Reactome IDs linked to a UniProt ID.""" linked_stable_ids = rx_id_from_up_id(up_id) if linked_stable_ids is None: - return ([], []) + return [], [] parents = [] for ls_id in linked_stable_ids: parents += _get_parents(ls_id) @@ -134,8 +133,8 @@ def get_all_parents(up_id): return sets, complexes -def get_rx_family_members(up_ids, cache_file=None): - """Get dictionary mapping Reactome sets/complexes to member Uniprot IDs.""" +def get_rx_family_members(fplx_id_to_children, cache_file=None): + """Get dictionary mapping Reactome sets/complexes to member UniProt IDs.""" # Check to see if we're loading from a cache if cache_file is not None and os.path.exists(cache_file): with open(cache_file, 'rt') as f: @@ -144,12 +143,12 @@ def get_rx_family_members(up_ids, cache_file=None): # Not cached, get members from the Reactome web service rx_family_members = {} - for be_id, children_up_ids in be_child_map.items(): - print("Getting family info for %s" % be_id) + for fplx_id, up_ids in fplx_id_to_children.items(): + print("Getting family info for FPLX:%s" % fplx_id) # For every child, get all parents in Reactome rx_sets = set([]) rx_complexes = set([]) - for up_id in children_up_ids: + for up_id in up_ids: sets, complexes = get_all_parents(up_id) rx_sets = rx_sets.union(sets) rx_complexes = rx_complexes.union(complexes) @@ -170,8 +169,10 @@ def get_rx_family_members(up_ids, cache_file=None): (rx_type, name, rx_id)) continue # Save info in dict - rx_family_members[rx_id] = {'name': name, 'type': rx_type, - 'members': list(rx_members)} + rx_family_members[rx_id] = { + 'name': name, 'type': rx_type, + 'members': list(rx_members) + } # Save to JSON with open('rx_family_members.json', 'wt') as f: json.dump(rx_family_members, f, indent=2) @@ -179,13 +180,14 @@ def get_rx_family_members(up_ids, cache_file=None): return rx_family_members -def get_mappings(be_child_map, rx_family_members, jaccard_cutoff=1.): +def get_mappings(fplx_id_to_children, rx_family_members, jaccard_cutoff=1.): """Find matches between FPLX and Reactome families/complexes.""" mappings = defaultdict(list) - for be_id, be_children in be_child_map.items(): + + for fplx_id, up_ids in fplx_id_to_children.items(): # Skip empty sets - be_set = set(be_children) - if not be_set: + up_ids = set(up_ids) + if not up_ids: continue for rx_id, rx_info in rx_family_members.items(): rx_name = rx_info['name'] @@ -194,24 +196,32 @@ def get_mappings(be_child_map, rx_family_members, jaccard_cutoff=1.): # Skip empty sets if not rx_set: continue - jacc = common.jaccard_index(be_set, rx_set) + jacc = jaccard_index(up_ids, rx_set) if jacc >= jaccard_cutoff: - mapping = {'reactomeId': rx_id, 'reactomeType': rx_type, - 'reactomeName': rx_name, - 'reactomeMembers': list(rx_set), - 'jaccardIndex': jacc} - mappings[be_id].append(mapping) - if be_id in mappings: - mappings[be_id].sort(key=lambda d: d['jaccardIndex'], reverse=True) - return mappings + mappings[fplx_id].append({ + 'reactomeId': rx_id, + 'reactomeType': rx_type, + 'reactomeName': rx_name, + 'reactomeMembers': list(rx_set), + 'jaccardIndex': jacc, + }) + + if fplx_id in mappings: + mappings[fplx_id].sort(key=lambda d: d['jaccardIndex'], reverse=True) + + return dict(mappings) + + +def main(): + fplx_child_map = get_child_map() + rx_family_members = get_rx_family_members( + fplx_child_map, + cache_file='rx_family_members.json', + ) + mappings = get_mappings(fplx_child_map, rx_family_members, jaccard_cutoff=1.) + with open('reactome_mappings.json', 'wt') as f: + json.dump(mappings, f, indent=2) if __name__ == '__main__': - be_child_map = common.get_child_map() - be_up_ids = [up_id for child_list in be_child_map.values() - for up_id in child_list] - rx_family_members = get_rx_family_members(be_up_ids, - cache_file='rx_family_members.json') - mappings = get_mappings(be_child_map, rx_family_members, jaccard_cutoff=1.) - with open('reactome_mappings.json', 'wt') as f: - json.dump(mappings, f, indent=2) + main() diff --git a/import/signor_mappings.py b/import/signor_mappings.py index 3856d29e3..133faa3d6 100644 --- a/import/signor_mappings.py +++ b/import/signor_mappings.py @@ -1,14 +1,16 @@ """Propose mappings between FamPlex and Signor families based on members.""" + import csv -from collections import namedtuple, defaultdict -import common +from collections import defaultdict + +from common import get_child_map, jaccard_index def get_signor_pf_map(pf_filename): signor_pf = {} with open(pf_filename, 'rt') as f: csvreader = csv.reader(f, delimiter=';') - next(csvreader) # Skip header row + next(csvreader) # Skip header row for row in csvreader: pf_id, pf_name, pf_member_list = row up_ids = [s.strip() for s in pf_member_list.split(',')] @@ -29,26 +31,31 @@ def get_mappings(fplx_child_map, signor_pf_map, jaccard_cutoff=1.): fplx_set = set(fplx_children) if not fplx_set: continue - jacc = common.jaccard_index(fplx_set, signor_set) + jacc = jaccard_index(fplx_set, signor_set) if jacc >= jaccard_cutoff: - mapping = {'signorId': signor_id, - 'signorName': signor_name, - 'signorMembers': list(signor_set), - 'fplxId': fplx_id, - 'fplxMembers': list(fplx_set), - 'eqEntry': 'SIGNOR,%s,%s' % (signor_id, fplx_id), - 'jaccardIndex': jacc} - mappings[signor_id].append(mapping) + mappings[signor_id].append({ + 'signorId': signor_id, + 'signorName': signor_name, + 'signorMembers': list(signor_set), + 'fplxId': fplx_id, + 'fplxMembers': list(fplx_set), + 'eqEntry': 'SIGNOR,%s,%s' % (signor_id, fplx_id), + 'jaccardIndex': jacc, + }) + if signor_id in mappings: - mappings[signor_id].sort(key=lambda d: d['jaccardIndex'], - reverse=True) - return mappings + mappings[signor_id].sort(key=lambda d: d['jaccardIndex'], reverse=True) + return dict(mappings) -if __name__ == '__main__': - fplx_child_map = common.get_child_map() + +def main(): + fplx_child_map = get_child_map() signor_pf_map = get_signor_pf_map('SIGNOR_PF.csv') mappings = get_mappings(fplx_child_map, signor_pf_map, jaccard_cutoff=1.) for k, v in mappings.items(): print(v[0]['eqEntry']) + +if __name__ == '__main__': + main()

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