Note: This is a work in progress and subject to change.
The following is a basic workflow in four steps:
Step (1) - Create a repo
$ repo.py --init
Step (2) - Add a target file
$ repo.py --add foo.tar.gz
Step (3) - Serve the repo
$ cd "tufrepo/"
$ python -m SimpleHTTPServer 8001
or with Python 3...
$ python3 -m http.server 8001
Step (4) - Retrieve a target file
$ cd "tufclient/"
$ client.py --repo http://localhost:8001 foo.tar.gz
See CLI.md for more examples. A tutorial is also available, and intended for users that want more control over the creation process.