diff --git a/bugsigdb_signatures_genus_metaphlan.gmt b/bugsigdb_signatures_genus_metaphlan.gmt
index 8939a9d71..84ff45b3b 100644
--- a/bugsigdb_signatures_genus_metaphlan.gmt
+++ b/bugsigdb_signatures_genus_metaphlan.gmt
@@ -1,4 +1,4 @@
-# BugSigDB 2025-01-14_11:58_UTC, License: Creative Commons Attribution 4.0 International, URL: https://bugsigdb.org
+# BugSigDB 2025-01-14_13:02_UTC, License: Creative Commons Attribution 4.0 International, URL: https://bugsigdb.org
 bsdb:1/1/1_Colorectal-adenoma:conventional-adenoma-cases_vs_controls_UP	NA	k__Bacteria|p__Actinomycetota|c__Actinomycetes|o__Actinomycetales|f__Actinomycetaceae|g__Actinomyces	k__Bacteria|p__Actinomycetota|c__Actinomycetes|o__Mycobacteriales|f__Corynebacteriaceae|g__Corynebacterium	k__Bacteria|p__Bacillota|c__Bacilli|o__Lactobacillales|f__Streptococcaceae|g__Streptococcus	k__Bacteria|p__Bacillota|c__Tissierellia|o__Tissierellales|f__Peptoniphilaceae|g__Peptoniphilus	k__Bacteria|p__Bacillota|c__Clostridia|o__Lachnospirales|f__Lachnospiraceae|g__Dorea	k__Bacteria|p__Bacillota|c__Negativicutes|o__Acidaminococcales|f__Acidaminococcaceae|g__Phascolarctobacterium	k__Bacteria|p__Pseudomonadota|c__Betaproteobacteria|o__Burkholderiales|f__Sutterellaceae|g__Sutterella	k__Bacteria|p__Bacillota|c__Bacilli|o__Lactobacillales|f__Lactobacillaceae|g__Lacticaseibacillus	k__Bacteria|p__Bacillota|c__Bacilli|o__Bacillales|f__Bacillaceae|g__Bacillus
 bsdb:1/1/2_Colorectal-adenoma:conventional-adenoma-cases_vs_controls_DOWN	NA	k__Bacteria|p__Bacillota|c__Erysipelotrichia|o__Erysipelotrichales|f__Coprobacillaceae|g__Coprobacillus
 bsdb:1/2/1_Hyperplastic-Polyp:hyperplastic-polyp-cases_vs_controls_UP	NA	k__Bacteria|p__Bacillota|c__Clostridia|o__Lachnospirales|f__Lachnospiraceae|g__Anaerostipes	k__Bacteria|p__Bacillota|c__Bacilli|o__Lactobacillales|f__Lactobacillaceae|g__Lacticaseibacillus
@@ -4570,12 +4570,12 @@ bsdb:1086/6/1_Phenylketonuria:Phenylketonuria-Children-subgingival-plaque-(PKU-C
 bsdb:1086/6/2_Phenylketonuria:Phenylketonuria-Children-subgingival-plaque-(PKU-Ch-SP)-patients_vs_Control-Children-subgingival-plaque-(Ctrl-Ch-SP)-patients_DOWN	NA	k__Bacteria|k__Pseudomonadati|p__Pseudomonadota|c__Gammaproteobacteria|o__Pasteurellales|f__Pasteurellaceae|g__Aggregatibacter	k__Bacteria|k__Pseudomonadati|p__Bacteroidota|c__Flavobacteriia|o__Flavobacteriales|f__Flavobacteriaceae|g__Capnocytophaga	k__Bacteria|k__Bacillati|p__Bacillota|c__Bacilli|o__Bacillales|f__Gemellaceae|g__Gemella	k__Bacteria|k__Fusobacteriati|p__Fusobacteriota|c__Fusobacteriia|o__Fusobacteriales|f__Leptotrichiaceae|g__Leptotrichia
 bsdb:1086/7/1_Phenylketonuria:ChCtrlUnrel-S-(unrelated-control-children-saliva)-patients_vs_ChCtrlRel-S-[related-control-children-saliva-(Healthy-siblings-of-PKU-patients)]_UP	NA	k__Bacteria|k__Pseudomonadati|p__Pseudomonadota|c__Gammaproteobacteria|o__Pasteurellales|f__Pasteurellaceae|g__Haemophilus	k__Bacteria|k__Bacillati|p__Bacillota|c__Clostridia|o__Lachnospirales|f__Lachnospiraceae|g__Lachnoanaerobaculum	k__Bacteria|k__Bacillati|p__Bacillota|c__Clostridia|o__Lachnospirales|f__Lachnospiraceae|g__Oribacterium
 bsdb:1086/7/2_Phenylketonuria:ChCtrlUnrel-S-(unrelated-control-children-saliva)-patients_vs_ChCtrlRel-S-[related-control-children-saliva-(Healthy-siblings-of-PKU-patients)]_DOWN	NA	k__Bacteria|k__Bacillati|p__Actinomycetota|c__Actinomycetes|o__Actinomycetales|f__Actinomycetaceae|g__Actinomyces	k__Bacteria|k__Bacillati|p__Actinomycetota|c__Actinomycetes|o__Propionibacteriales|f__Propionibacteriaceae|g__Arachnia	k__Bacteria|k__Bacillati|p__Actinomycetota|c__Coriobacteriia|o__Coriobacteriales|f__Atopobiaceae|g__Atopobium	k__Bacteria|k__Thermotogati|p__Synergistota|c__Synergistia|o__Synergistales|f__Aminobacteriaceae|g__Fretibacterium	k__Bacteria|k__Pseudomonadati|p__Pseudomonadota|c__Betaproteobacteria|o__Burkholderiales|f__Burkholderiaceae|g__Lautropia	k__Bacteria|k__Bacillati|p__Bacillota|c__Clostridia|o__Peptostreptococcales|f__Peptostreptococcaceae|g__Peptostreptococcus
-bsdb:1086/8/1_Phenylketonuria:Ch-PKU-(PKU-children)_vs_Ch-CTRL-rel-(Healthy-siblings-of-PKU-patients)_UP	NA	k__Bacteria|p__Bacteroidota|c__Flavobacteriia|o__Flavobacteriales|f__Flavobacteriaceae|g__Capnocytophaga	k__Bacteria|p__Bacillota|c__Clostridia|o__Peptostreptococcales|f__Peptostreptococcaceae|g__Peptostreptococcus	k__Bacteria|p__Bacillota|c__Clostridia|o__Eubacteriales|f__Peptococcaceae|g__Peptococcus	k__Bacteria|p__Fusobacteriota|c__Fusobacteriia|o__Fusobacteriales|f__Leptotrichiaceae|g__Leptotrichia	k__Bacteria|p__Bacillota|c__Clostridia|o__Lachnospirales|f__Lachnospiraceae|g__Lachnoanaerobaculum	k__Bacteria|p__Bacteroidota|c__Bacteroidia|o__Bacteroidales|f__Porphyromonadaceae|g__Porphyromonas	k__Bacteria|p__Pseudomonadota|c__Gammaproteobacteria|o__Pasteurellales|f__Pasteurellaceae|g__Aggregatibacter
-bsdb:1086/8/2_Phenylketonuria:Ch-PKU-(PKU-children)_vs_Ch-CTRL-rel-(Healthy-siblings-of-PKU-patients)_DOWN	NA	k__Bacteria|p__Actinomycetota|c__Coriobacteriia|o__Coriobacteriales|f__Atopobiaceae|g__Olsenella	k__Bacteria|p__Bacillota|c__Negativicutes|o__Selenomonadales|f__Selenomonadaceae|g__Selenomonas	k__Bacteria|p__Actinomycetota|c__Coriobacteriia|o__Coriobacteriales|f__Atopobiaceae|g__Atopobium	k__Bacteria|p__Actinomycetota|c__Actinomycetes|o__Actinomycetales|f__Actinomycetaceae|g__Actinomyces	k__Bacteria|p__Synergistota|c__Synergistia|o__Synergistales|f__Aminobacteriaceae|g__Fretibacterium
-bsdb:1086/9/1_Phenylketonuria:Control-(CTRL-SP)_vs_Control-(CTRL-S)_UP	NA	k__Bacteria|p__Bacillota|c__Negativicutes|o__Veillonellales|f__Veillonellaceae|g__Veillonella	k__Bacteria|p__Bacillota|c__Bacilli|o__Lactobacillales|f__Streptococcaceae|g__Streptococcus	k__Bacteria|p__Bacillota|c__Clostridia|o__Lachnospirales|f__Lachnospiraceae|g__Stomatobaculum	k__Bacteria|p__Bacillota|c__Clostridia|o__Peptostreptococcales|f__Peptostreptococcaceae|g__Peptostreptococcus	k__Bacteria|p__Pseudomonadota|c__Gammaproteobacteria|o__Pasteurellales|f__Pasteurellaceae|g__Haemophilus	k__Bacteria|p__Bacillota|c__Bacilli|o__Bacillales|f__Gemellaceae|g__Gemella	k__Bacteria|p__Actinomycetota|c__Coriobacteriia|o__Coriobacteriales|f__Atopobiaceae|g__Atopobium	k__Bacteria|p__Bacteroidota|c__Bacteroidia|o__Bacteroidales|f__Prevotellaceae|g__Alloprevotella	k__Bacteria|p__Pseudomonadota|c__Betaproteobacteria|o__Neisseriales|f__Neisseriaceae|g__Neisseria	k__Bacteria|p__Bacteroidota|c__Bacteroidia|o__Bacteroidales|f__Porphyromonadaceae|g__Porphyromonas	k__Bacteria|p__Bacillota|c__Clostridia|o__Lachnospirales|f__Lachnospiraceae|g__Oribacterium	k__Bacteria|p__Bacteroidota|c__Bacteroidia|o__Bacteroidales|f__Prevotellaceae|g__Prevotella
-bsdb:1086/9/2_Phenylketonuria:Control-(CTRL-SP)_vs_Control-(CTRL-S)_DOWN	NA	k__Bacteria|p__Pseudomonadota|c__Gammaproteobacteria|o__Pasteurellales|f__Pasteurellaceae|g__Aggregatibacter	k__Bacteria|p__Actinomycetota|c__Actinomycetes|o__Propionibacteriales|f__Propionibacteriaceae|g__Arachnia	k__Bacteria|p__Campylobacterota|c__Epsilonproteobacteria|o__Campylobacterales|f__Campylobacteraceae|g__Campylobacter	k__Bacteria|p__Bacteroidota|c__Flavobacteriia|o__Flavobacteriales|f__Flavobacteriaceae|g__Capnocytophaga	k__Bacteria|p__Pseudomonadota|c__Gammaproteobacteria|o__Cardiobacteriales|f__Cardiobacteriaceae|g__Cardiobacterium	k__Bacteria|p__Actinomycetota|c__Actinomycetes|o__Mycobacteriales|f__Corynebacteriaceae|g__Corynebacterium	k__Bacteria|p__Fusobacteriota|c__Fusobacteriia|o__Fusobacteriales|f__Fusobacteriaceae|g__Fusobacterium	k__Bacteria|p__Pseudomonadota|c__Betaproteobacteria|o__Neisseriales|f__Neisseriaceae|g__Kingella	k__Bacteria|p__Fusobacteriota|c__Fusobacteriia|o__Fusobacteriales|f__Leptotrichiaceae|g__Leptotrichia	k__Bacteria|p__Actinomycetota|c__Coriobacteriia|o__Coriobacteriales|f__Atopobiaceae|g__Olsenella	k__Bacteria|p__Bacillota|c__Negativicutes|o__Selenomonadales|f__Selenomonadaceae|g__Selenomonas	k__Bacteria|p__Bacteroidota|c__Bacteroidia|o__Bacteroidales|f__Tannerellaceae|g__Tannerella
-bsdb:1086/10/1_Phenylketonuria:Control-Adults-(CTRL-SP)_vs_Control-Adults-(CTRL-S)_UP	NA	k__Bacteria|p__Bacillota|c__Negativicutes|o__Veillonellales|f__Veillonellaceae|g__Veillonella	k__Bacteria|p__Bacillota|c__Bacilli|o__Lactobacillales|f__Streptococcaceae|g__Streptococcus	k__Bacteria|p__Bacillota|c__Clostridia|o__Lachnospirales|f__Lachnospiraceae|g__Stomatobaculum	k__Bacteria|p__Bacillota|c__Clostridia|o__Peptostreptococcales|f__Peptostreptococcaceae|g__Peptostreptococcus	k__Bacteria|p__Pseudomonadota|c__Gammaproteobacteria|o__Pasteurellales|f__Pasteurellaceae|g__Haemophilus	k__Bacteria|p__Bacillota|c__Bacilli|o__Bacillales|f__Gemellaceae|g__Gemella	k__Bacteria|p__Actinomycetota|c__Coriobacteriia|o__Coriobacteriales|f__Atopobiaceae|g__Atopobium	k__Bacteria|p__Bacteroidota|c__Bacteroidia|o__Bacteroidales|f__Prevotellaceae|g__Alloprevotella	k__Bacteria|p__Pseudomonadota|c__Betaproteobacteria|o__Neisseriales|f__Neisseriaceae|g__Neisseria	k__Bacteria|p__Bacteroidota|c__Bacteroidia|o__Bacteroidales|f__Porphyromonadaceae|g__Porphyromonas	k__Bacteria|p__Bacillota|c__Clostridia|o__Lachnospirales|f__Lachnospiraceae|g__Oribacterium	k__Bacteria|p__Bacteroidota|c__Bacteroidia|o__Bacteroidales|f__Prevotellaceae|g__Prevotella
-bsdb:1086/10/2_Phenylketonuria:Control-Adults-(CTRL-SP)_vs_Control-Adults-(CTRL-S)_DOWN	NA	k__Bacteria|p__Pseudomonadota|c__Gammaproteobacteria|o__Pasteurellales|f__Pasteurellaceae|g__Aggregatibacter	k__Bacteria|p__Actinomycetota|c__Actinomycetes|o__Propionibacteriales|f__Propionibacteriaceae|g__Arachnia	k__Bacteria|p__Campylobacterota|c__Epsilonproteobacteria|o__Campylobacterales|f__Campylobacteraceae|g__Campylobacter	k__Bacteria|p__Bacteroidota|c__Flavobacteriia|o__Flavobacteriales|f__Flavobacteriaceae|g__Capnocytophaga	k__Bacteria|p__Pseudomonadota|c__Gammaproteobacteria|o__Cardiobacteriales|f__Cardiobacteriaceae|g__Cardiobacterium	k__Bacteria|p__Actinomycetota|c__Actinomycetes|o__Mycobacteriales|f__Corynebacteriaceae|g__Corynebacterium	k__Bacteria|p__Fusobacteriota|c__Fusobacteriia|o__Fusobacteriales|f__Fusobacteriaceae|g__Fusobacterium	k__Bacteria|p__Pseudomonadota|c__Betaproteobacteria|o__Neisseriales|f__Neisseriaceae|g__Kingella	k__Bacteria|p__Actinomycetota|c__Coriobacteriia|o__Coriobacteriales|f__Atopobiaceae|g__Olsenella	k__Bacteria|p__Bacillota|c__Negativicutes|o__Selenomonadales|f__Selenomonadaceae|g__Selenomonas	k__Bacteria|p__Bacteroidota|c__Bacteroidia|o__Bacteroidales|f__Tannerellaceae|g__Tannerella
+bsdb:1086/8/1_Phenylketonuria:ChPKU-S-(PKU-children-saliva)-patients_vs_ChCtrlRel-S-[related-control-children-saliva-(Healthy-siblings-of-PKU-patients)]_UP	NA	k__Bacteria|p__Bacteroidota|c__Flavobacteriia|o__Flavobacteriales|f__Flavobacteriaceae|g__Capnocytophaga	k__Bacteria|p__Bacillota|c__Clostridia|o__Peptostreptococcales|f__Peptostreptococcaceae|g__Peptostreptococcus	k__Bacteria|p__Bacillota|c__Clostridia|o__Eubacteriales|f__Peptococcaceae|g__Peptococcus	k__Bacteria|p__Fusobacteriota|c__Fusobacteriia|o__Fusobacteriales|f__Leptotrichiaceae|g__Leptotrichia	k__Bacteria|p__Bacillota|c__Clostridia|o__Lachnospirales|f__Lachnospiraceae|g__Lachnoanaerobaculum	k__Bacteria|p__Bacteroidota|c__Bacteroidia|o__Bacteroidales|f__Porphyromonadaceae|g__Porphyromonas	k__Bacteria|p__Pseudomonadota|c__Gammaproteobacteria|o__Pasteurellales|f__Pasteurellaceae|g__Aggregatibacter
+bsdb:1086/8/2_Phenylketonuria:ChPKU-S-(PKU-children-saliva)-patients_vs_ChCtrlRel-S-[related-control-children-saliva-(Healthy-siblings-of-PKU-patients)]_DOWN	NA	k__Bacteria|p__Actinomycetota|c__Coriobacteriia|o__Coriobacteriales|f__Atopobiaceae|g__Olsenella	k__Bacteria|p__Bacillota|c__Negativicutes|o__Selenomonadales|f__Selenomonadaceae|g__Selenomonas	k__Bacteria|p__Actinomycetota|c__Coriobacteriia|o__Coriobacteriales|f__Atopobiaceae|g__Atopobium	k__Bacteria|p__Actinomycetota|c__Actinomycetes|o__Actinomycetales|f__Actinomycetaceae|g__Actinomyces	k__Bacteria|p__Synergistota|c__Synergistia|o__Synergistales|f__Aminobacteriaceae|g__Fretibacterium
+bsdb:1086/9/1_Phenylketonuria:Control-Subgingival-plaque-(Ctrl-SP)-patients_vs_Control-Saliva-(Ctrl-S)-patients_UP	NA	k__Bacteria|k__Pseudomonadati|p__Bacteroidota|c__Bacteroidia|o__Bacteroidales|f__Prevotellaceae|g__Alloprevotella	k__Bacteria|k__Bacillati|p__Actinomycetota|c__Coriobacteriia|o__Coriobacteriales|f__Atopobiaceae|g__Atopobium	k__Bacteria|k__Bacillati|p__Bacillota|c__Bacilli|o__Bacillales|f__Gemellaceae|g__Gemella	k__Bacteria|k__Pseudomonadati|p__Pseudomonadota|c__Gammaproteobacteria|o__Pasteurellales|f__Pasteurellaceae|g__Haemophilus	k__Bacteria|k__Pseudomonadati|p__Pseudomonadota|c__Betaproteobacteria|o__Neisseriales|f__Neisseriaceae|g__Neisseria	k__Bacteria|k__Bacillati|p__Bacillota|c__Clostridia|o__Lachnospirales|f__Lachnospiraceae|g__Oribacterium	k__Bacteria|k__Bacillati|p__Bacillota|c__Clostridia|o__Peptostreptococcales|f__Peptostreptococcaceae|g__Peptostreptococcus	k__Bacteria|k__Pseudomonadati|p__Bacteroidota|c__Bacteroidia|o__Bacteroidales|f__Porphyromonadaceae|g__Porphyromonas	k__Bacteria|k__Pseudomonadati|p__Bacteroidota|c__Bacteroidia|o__Bacteroidales|f__Prevotellaceae|g__Prevotella	k__Bacteria|k__Bacillati|p__Bacillota|c__Clostridia|o__Lachnospirales|f__Lachnospiraceae|g__Stomatobaculum	k__Bacteria|k__Bacillati|p__Bacillota|c__Bacilli|o__Lactobacillales|f__Streptococcaceae|g__Streptococcus	k__Bacteria|k__Bacillati|p__Bacillota|c__Negativicutes|o__Veillonellales|f__Veillonellaceae|g__Veillonella	k__Eukaryota|k__Viridiplantae|p__Streptophyta|c__Magnoliopsida|o__Fabales|f__Fabaceae|s__Papilionoideae|g__Rothia	k__Bacteria|k__Bacillati|p__Bacillota|c__Clostridia|o__Lachnospirales|f__Lachnospiraceae|g__Lachnoanaerobaculum
+bsdb:1086/9/2_Phenylketonuria:Control-Subgingival-plaque-(Ctrl-SP)-patients_vs_Control-Saliva-(Ctrl-S)-patients_DOWN	NA	k__Bacteria|k__Pseudomonadati|p__Pseudomonadota|c__Gammaproteobacteria|o__Pasteurellales|f__Pasteurellaceae|g__Aggregatibacter	k__Bacteria|k__Bacillati|p__Actinomycetota|c__Actinomycetes|o__Propionibacteriales|f__Propionibacteriaceae|g__Arachnia	k__Bacteria|k__Pseudomonadati|p__Campylobacterota|c__Epsilonproteobacteria|o__Campylobacterales|f__Campylobacteraceae|g__Campylobacter	k__Bacteria|k__Pseudomonadati|p__Bacteroidota|c__Flavobacteriia|o__Flavobacteriales|f__Flavobacteriaceae|g__Capnocytophaga	k__Bacteria|k__Pseudomonadati|p__Pseudomonadota|c__Gammaproteobacteria|o__Cardiobacteriales|f__Cardiobacteriaceae|g__Cardiobacterium	k__Bacteria|k__Bacillati|p__Actinomycetota|c__Actinomycetes|o__Mycobacteriales|f__Corynebacteriaceae|g__Corynebacterium	k__Bacteria|k__Fusobacteriati|p__Fusobacteriota|c__Fusobacteriia|o__Fusobacteriales|f__Fusobacteriaceae|g__Fusobacterium	k__Bacteria|k__Pseudomonadati|p__Pseudomonadota|c__Betaproteobacteria|o__Neisseriales|f__Neisseriaceae|g__Kingella	k__Bacteria|k__Fusobacteriati|p__Fusobacteriota|c__Fusobacteriia|o__Fusobacteriales|f__Leptotrichiaceae|g__Leptotrichia	k__Bacteria|k__Bacillati|p__Actinomycetota|c__Coriobacteriia|o__Coriobacteriales|f__Atopobiaceae|g__Olsenella	k__Bacteria|k__Bacillati|p__Bacillota|c__Negativicutes|o__Selenomonadales|f__Selenomonadaceae|g__Selenomonas	k__Bacteria|k__Pseudomonadati|p__Bacteroidota|c__Bacteroidia|o__Bacteroidales|f__Tannerellaceae|g__Tannerella
+bsdb:1086/10/1_Phenylketonuria:Control-Adults-Subgingival-plaque-(Ctrl-Adults-SP)-patients_vs_Control-Adults-Saliva-(Ctrl-Adults-S)-patients_UP	NA	k__Bacteria|k__Pseudomonadati|p__Bacteroidota|c__Bacteroidia|o__Bacteroidales|f__Prevotellaceae|g__Alloprevotella	k__Bacteria|k__Bacillati|p__Actinomycetota|c__Coriobacteriia|o__Coriobacteriales|f__Atopobiaceae|g__Atopobium	k__Bacteria|k__Bacillati|p__Bacillota|c__Bacilli|o__Bacillales|f__Gemellaceae|g__Gemella	k__Bacteria|k__Pseudomonadati|p__Pseudomonadota|c__Gammaproteobacteria|o__Pasteurellales|f__Pasteurellaceae|g__Haemophilus	k__Bacteria|k__Pseudomonadati|p__Pseudomonadota|c__Betaproteobacteria|o__Neisseriales|f__Neisseriaceae|g__Neisseria	k__Bacteria|k__Bacillati|p__Bacillota|c__Clostridia|o__Lachnospirales|f__Lachnospiraceae|g__Oribacterium	k__Bacteria|k__Bacillati|p__Bacillota|c__Clostridia|o__Peptostreptococcales|f__Peptostreptococcaceae|g__Peptostreptococcus	k__Bacteria|k__Pseudomonadati|p__Bacteroidota|c__Bacteroidia|o__Bacteroidales|f__Porphyromonadaceae|g__Porphyromonas	k__Bacteria|k__Pseudomonadati|p__Bacteroidota|c__Bacteroidia|o__Bacteroidales|f__Prevotellaceae|g__Prevotella	k__Bacteria|k__Bacillati|p__Bacillota|c__Clostridia|o__Lachnospirales|f__Lachnospiraceae|g__Stomatobaculum	k__Bacteria|k__Bacillati|p__Bacillota|c__Bacilli|o__Lactobacillales|f__Streptococcaceae|g__Streptococcus	k__Bacteria|k__Bacillati|p__Bacillota|c__Negativicutes|o__Veillonellales|f__Veillonellaceae|g__Veillonella	k__Eukaryota|k__Viridiplantae|p__Streptophyta|c__Magnoliopsida|o__Fabales|f__Fabaceae|s__Papilionoideae|g__Rothia
+bsdb:1086/10/2_Phenylketonuria:Control-Adults-Subgingival-plaque-(Ctrl-Adults-SP)-patients_vs_Control-Adults-Saliva-(Ctrl-Adults-S)-patients_DOWN	NA	k__Bacteria|k__Pseudomonadati|p__Pseudomonadota|c__Gammaproteobacteria|o__Pasteurellales|f__Pasteurellaceae|g__Aggregatibacter	k__Bacteria|k__Bacillati|p__Actinomycetota|c__Actinomycetes|o__Propionibacteriales|f__Propionibacteriaceae|g__Arachnia	k__Bacteria|k__Pseudomonadati|p__Campylobacterota|c__Epsilonproteobacteria|o__Campylobacterales|f__Campylobacteraceae|g__Campylobacter	k__Bacteria|k__Pseudomonadati|p__Bacteroidota|c__Flavobacteriia|o__Flavobacteriales|f__Flavobacteriaceae|g__Capnocytophaga	k__Bacteria|k__Pseudomonadati|p__Pseudomonadota|c__Gammaproteobacteria|o__Cardiobacteriales|f__Cardiobacteriaceae|g__Cardiobacterium	k__Bacteria|k__Bacillati|p__Actinomycetota|c__Actinomycetes|o__Mycobacteriales|f__Corynebacteriaceae|g__Corynebacterium	k__Bacteria|k__Fusobacteriati|p__Fusobacteriota|c__Fusobacteriia|o__Fusobacteriales|f__Fusobacteriaceae|g__Fusobacterium	k__Bacteria|k__Pseudomonadati|p__Pseudomonadota|c__Betaproteobacteria|o__Neisseriales|f__Neisseriaceae|g__Kingella	k__Bacteria|k__Bacillati|p__Actinomycetota|c__Coriobacteriia|o__Coriobacteriales|f__Atopobiaceae|g__Olsenella	k__Bacteria|k__Bacillati|p__Bacillota|c__Negativicutes|o__Selenomonadales|f__Selenomonadaceae|g__Selenomonas	k__Bacteria|k__Pseudomonadati|p__Bacteroidota|c__Bacteroidia|o__Bacteroidales|f__Tannerellaceae|g__Tannerella
 bsdb:1086/11/1_Phenylketonuria:Control-Children-(CTRL-Ch-SP)_vs_Control-Children-(CTRL-Ch-S)_UP	NA	k__Bacteria|p__Bacteroidota|c__Bacteroidia|o__Bacteroidales|f__Prevotellaceae|g__Prevotella	k__Bacteria|p__Bacillota|c__Clostridia|o__Lachnospirales|f__Lachnospiraceae|g__Oribacterium	k__Bacteria|p__Bacteroidota|c__Bacteroidia|o__Bacteroidales|f__Porphyromonadaceae|g__Porphyromonas	k__Bacteria|p__Pseudomonadota|c__Betaproteobacteria|o__Neisseriales|f__Neisseriaceae|g__Neisseria	k__Bacteria|p__Bacteroidota|c__Bacteroidia|o__Bacteroidales|f__Prevotellaceae|g__Alloprevotella	k__Bacteria|p__Actinomycetota|c__Coriobacteriia|o__Coriobacteriales|f__Atopobiaceae|g__Atopobium	k__Bacteria|p__Bacillota|c__Bacilli|o__Bacillales|f__Gemellaceae|g__Gemella	k__Bacteria|p__Pseudomonadota|c__Gammaproteobacteria|o__Pasteurellales|f__Pasteurellaceae|g__Haemophilus	k__Bacteria|p__Bacillota|c__Clostridia|o__Peptostreptococcales|f__Peptostreptococcaceae|g__Peptostreptococcus	k__Bacteria|p__Bacillota|c__Clostridia|o__Lachnospirales|f__Lachnospiraceae|g__Stomatobaculum	k__Bacteria|p__Bacillota|c__Bacilli|o__Lactobacillales|f__Streptococcaceae|g__Streptococcus	k__Bacteria|p__Bacillota|c__Negativicutes|o__Veillonellales|f__Veillonellaceae|g__Veillonella
 bsdb:1086/11/2_Phenylketonuria:Control-Children-(CTRL-Ch-SP)_vs_Control-Children-(CTRL-Ch-S)_DOWN	NA	k__Bacteria|p__Bacteroidota|c__Flavobacteriia|o__Flavobacteriales|f__Flavobacteriaceae|g__Capnocytophaga	k__Bacteria|p__Fusobacteriota|c__Fusobacteriia|o__Fusobacteriales|f__Fusobacteriaceae|g__Fusobacterium	k__Bacteria|p__Actinomycetota|c__Actinomycetes|o__Mycobacteriales|f__Corynebacteriaceae|g__Corynebacterium	k__Bacteria|p__Pseudomonadota|c__Betaproteobacteria|o__Neisseriales|f__Neisseriaceae|g__Kingella	k__Bacteria|p__Actinomycetota|c__Actinomycetes|o__Propionibacteriales|f__Propionibacteriaceae|g__Arachnia	k__Bacteria|p__Pseudomonadota|c__Gammaproteobacteria|o__Cardiobacteriales|f__Cardiobacteriaceae|g__Cardiobacterium	k__Bacteria|p__Actinomycetota|c__Coriobacteriia|o__Coriobacteriales|f__Atopobiaceae|g__Olsenella	k__Bacteria|p__Bacteroidota|c__Bacteroidia|o__Bacteroidales|f__Tannerellaceae|g__Tannerella	k__Bacteria|p__Campylobacterota|c__Epsilonproteobacteria|o__Campylobacterales|f__Campylobacteraceae|g__Campylobacter	k__Bacteria|p__Synergistota|c__Synergistia|o__Synergistales|f__Aminobacteriaceae|g__Fretibacterium
 bsdb:1086/12/1_Phenylketonuria:Phenylketonuria-(PKU-SP)_vs_Phenylketonuria-(PKU-S)_UP	NA	k__Bacteria|p__Bacteroidota|c__Bacteroidia|o__Bacteroidales|f__Prevotellaceae|g__Alloprevotella	k__Bacteria|p__Actinomycetota|c__Coriobacteriia|o__Coriobacteriales|f__Atopobiaceae|g__Atopobium	k__Bacteria|p__Bacillota|c__Bacilli|o__Bacillales|f__Gemellaceae|g__Gemella	k__Bacteria|p__Pseudomonadota|c__Gammaproteobacteria|o__Pasteurellales|f__Pasteurellaceae|g__Haemophilus	k__Bacteria|p__Bacillota|c__Clostridia|o__Lachnospirales|f__Lachnospiraceae|g__Lachnoanaerobaculum	k__Bacteria|p__Pseudomonadota|c__Betaproteobacteria|o__Neisseriales|f__Neisseriaceae|g__Neisseria	k__Bacteria|p__Bacillota|c__Clostridia|o__Lachnospirales|f__Lachnospiraceae|g__Oribacterium	k__Bacteria|p__Bacillota|c__Clostridia|o__Peptostreptococcales|f__Peptostreptococcaceae|g__Peptostreptococcus	k__Bacteria|p__Bacteroidota|c__Bacteroidia|o__Bacteroidales|f__Porphyromonadaceae|g__Porphyromonas	k__Bacteria|p__Bacteroidota|c__Bacteroidia|o__Bacteroidales|f__Prevotellaceae|g__Prevotella	k__Eukaryota|k__Viridiplantae|p__Streptophyta|c__Magnoliopsida|o__Fabales|f__Fabaceae|s__Papilionoideae|g__Rothia	k__Bacteria|p__Bacillota|c__Clostridia|o__Lachnospirales|f__Lachnospiraceae|g__Stomatobaculum	k__Bacteria|p__Bacillota|c__Bacilli|o__Lactobacillales|f__Streptococcaceae|g__Streptococcus	k__Bacteria|p__Bacillota|c__Negativicutes|o__Veillonellales|f__Veillonellaceae|g__Veillonella
diff --git a/bugsigdb_signatures_genus_metaphlan_exact.gmt b/bugsigdb_signatures_genus_metaphlan_exact.gmt
index 144177130..b8315a86e 100644
--- a/bugsigdb_signatures_genus_metaphlan_exact.gmt
+++ b/bugsigdb_signatures_genus_metaphlan_exact.gmt
@@ -1,4 +1,4 @@
-# BugSigDB 2025-01-14_11:58_UTC, License: Creative Commons Attribution 4.0 International, URL: https://bugsigdb.org
+# BugSigDB 2025-01-14_13:02_UTC, License: Creative Commons Attribution 4.0 International, URL: https://bugsigdb.org
 bsdb:1/1/1_Colorectal-adenoma:conventional-adenoma-cases_vs_controls_UP	NA	k__Bacteria|p__Actinomycetota|c__Actinomycetes|o__Actinomycetales|f__Actinomycetaceae|g__Actinomyces	k__Bacteria|p__Actinomycetota|c__Actinomycetes|o__Mycobacteriales|f__Corynebacteriaceae|g__Corynebacterium	k__Bacteria|p__Bacillota|c__Bacilli|o__Lactobacillales|f__Streptococcaceae|g__Streptococcus	k__Bacteria|p__Bacillota|c__Tissierellia|o__Tissierellales|f__Peptoniphilaceae|g__Peptoniphilus	k__Bacteria|p__Bacillota|c__Clostridia|o__Lachnospirales|f__Lachnospiraceae|g__Dorea	k__Bacteria|p__Bacillota|c__Negativicutes|o__Acidaminococcales|f__Acidaminococcaceae|g__Phascolarctobacterium	k__Bacteria|p__Pseudomonadota|c__Betaproteobacteria|o__Burkholderiales|f__Sutterellaceae|g__Sutterella	k__Bacteria|p__Bacillota|c__Bacilli|o__Bacillales|f__Bacillaceae|g__Bacillus
 bsdb:1/1/2_Colorectal-adenoma:conventional-adenoma-cases_vs_controls_DOWN	NA	k__Bacteria|p__Bacillota|c__Erysipelotrichia|o__Erysipelotrichales|f__Coprobacillaceae|g__Coprobacillus
 bsdb:1/2/1_Hyperplastic-Polyp:hyperplastic-polyp-cases_vs_controls_UP	NA	k__Bacteria|p__Bacillota|c__Clostridia|o__Lachnospirales|f__Lachnospiraceae|g__Anaerostipes
@@ -3825,12 +3825,12 @@ bsdb:1086/6/1_Phenylketonuria:Phenylketonuria-Children-subgingival-plaque-(PKU-C
 bsdb:1086/6/2_Phenylketonuria:Phenylketonuria-Children-subgingival-plaque-(PKU-Ch-SP)-patients_vs_Control-Children-subgingival-plaque-(Ctrl-Ch-SP)-patients_DOWN	NA	k__Bacteria|k__Pseudomonadati|p__Pseudomonadota|c__Gammaproteobacteria|o__Pasteurellales|f__Pasteurellaceae|g__Aggregatibacter	k__Bacteria|k__Pseudomonadati|p__Bacteroidota|c__Flavobacteriia|o__Flavobacteriales|f__Flavobacteriaceae|g__Capnocytophaga	k__Bacteria|k__Bacillati|p__Bacillota|c__Bacilli|o__Bacillales|f__Gemellaceae|g__Gemella	k__Bacteria|k__Fusobacteriati|p__Fusobacteriota|c__Fusobacteriia|o__Fusobacteriales|f__Leptotrichiaceae|g__Leptotrichia
 bsdb:1086/7/1_Phenylketonuria:ChCtrlUnrel-S-(unrelated-control-children-saliva)-patients_vs_ChCtrlRel-S-[related-control-children-saliva-(Healthy-siblings-of-PKU-patients)]_UP	NA	k__Bacteria|k__Pseudomonadati|p__Pseudomonadota|c__Gammaproteobacteria|o__Pasteurellales|f__Pasteurellaceae|g__Haemophilus	k__Bacteria|k__Bacillati|p__Bacillota|c__Clostridia|o__Lachnospirales|f__Lachnospiraceae|g__Lachnoanaerobaculum	k__Bacteria|k__Bacillati|p__Bacillota|c__Clostridia|o__Lachnospirales|f__Lachnospiraceae|g__Oribacterium
 bsdb:1086/7/2_Phenylketonuria:ChCtrlUnrel-S-(unrelated-control-children-saliva)-patients_vs_ChCtrlRel-S-[related-control-children-saliva-(Healthy-siblings-of-PKU-patients)]_DOWN	NA	k__Bacteria|k__Bacillati|p__Actinomycetota|c__Actinomycetes|o__Actinomycetales|f__Actinomycetaceae|g__Actinomyces	k__Bacteria|k__Bacillati|p__Actinomycetota|c__Actinomycetes|o__Propionibacteriales|f__Propionibacteriaceae|g__Arachnia	k__Bacteria|k__Bacillati|p__Actinomycetota|c__Coriobacteriia|o__Coriobacteriales|f__Atopobiaceae|g__Atopobium	k__Bacteria|k__Thermotogati|p__Synergistota|c__Synergistia|o__Synergistales|f__Aminobacteriaceae|g__Fretibacterium	k__Bacteria|k__Pseudomonadati|p__Pseudomonadota|c__Betaproteobacteria|o__Burkholderiales|f__Burkholderiaceae|g__Lautropia	k__Bacteria|k__Bacillati|p__Bacillota|c__Clostridia|o__Peptostreptococcales|f__Peptostreptococcaceae|g__Peptostreptococcus
-bsdb:1086/8/1_Phenylketonuria:Ch-PKU-(PKU-children)_vs_Ch-CTRL-rel-(Healthy-siblings-of-PKU-patients)_UP	NA	k__Bacteria|p__Bacteroidota|c__Flavobacteriia|o__Flavobacteriales|f__Flavobacteriaceae|g__Capnocytophaga	k__Bacteria|p__Bacillota|c__Clostridia|o__Peptostreptococcales|f__Peptostreptococcaceae|g__Peptostreptococcus	k__Bacteria|p__Bacillota|c__Clostridia|o__Eubacteriales|f__Peptococcaceae|g__Peptococcus	k__Bacteria|p__Fusobacteriota|c__Fusobacteriia|o__Fusobacteriales|f__Leptotrichiaceae|g__Leptotrichia	k__Bacteria|p__Bacillota|c__Clostridia|o__Lachnospirales|f__Lachnospiraceae|g__Lachnoanaerobaculum	k__Bacteria|p__Bacteroidota|c__Bacteroidia|o__Bacteroidales|f__Porphyromonadaceae|g__Porphyromonas	k__Bacteria|p__Pseudomonadota|c__Gammaproteobacteria|o__Pasteurellales|f__Pasteurellaceae|g__Aggregatibacter
-bsdb:1086/8/2_Phenylketonuria:Ch-PKU-(PKU-children)_vs_Ch-CTRL-rel-(Healthy-siblings-of-PKU-patients)_DOWN	NA	k__Bacteria|p__Actinomycetota|c__Coriobacteriia|o__Coriobacteriales|f__Atopobiaceae|g__Olsenella	k__Bacteria|p__Bacillota|c__Negativicutes|o__Selenomonadales|f__Selenomonadaceae|g__Selenomonas	k__Bacteria|p__Actinomycetota|c__Coriobacteriia|o__Coriobacteriales|f__Atopobiaceae|g__Atopobium	k__Bacteria|p__Actinomycetota|c__Actinomycetes|o__Actinomycetales|f__Actinomycetaceae|g__Actinomyces	k__Bacteria|p__Synergistota|c__Synergistia|o__Synergistales|f__Aminobacteriaceae|g__Fretibacterium
-bsdb:1086/9/1_Phenylketonuria:Control-(CTRL-SP)_vs_Control-(CTRL-S)_UP	NA	k__Bacteria|p__Bacillota|c__Negativicutes|o__Veillonellales|f__Veillonellaceae|g__Veillonella	k__Bacteria|p__Bacillota|c__Bacilli|o__Lactobacillales|f__Streptococcaceae|g__Streptococcus	k__Bacteria|p__Bacillota|c__Clostridia|o__Lachnospirales|f__Lachnospiraceae|g__Stomatobaculum	k__Bacteria|p__Bacillota|c__Clostridia|o__Peptostreptococcales|f__Peptostreptococcaceae|g__Peptostreptococcus	k__Bacteria|p__Pseudomonadota|c__Gammaproteobacteria|o__Pasteurellales|f__Pasteurellaceae|g__Haemophilus	k__Bacteria|p__Bacillota|c__Bacilli|o__Bacillales|f__Gemellaceae|g__Gemella	k__Bacteria|p__Actinomycetota|c__Coriobacteriia|o__Coriobacteriales|f__Atopobiaceae|g__Atopobium	k__Bacteria|p__Bacteroidota|c__Bacteroidia|o__Bacteroidales|f__Prevotellaceae|g__Alloprevotella	k__Bacteria|p__Pseudomonadota|c__Betaproteobacteria|o__Neisseriales|f__Neisseriaceae|g__Neisseria	k__Bacteria|p__Bacteroidota|c__Bacteroidia|o__Bacteroidales|f__Porphyromonadaceae|g__Porphyromonas	k__Bacteria|p__Bacillota|c__Clostridia|o__Lachnospirales|f__Lachnospiraceae|g__Oribacterium	k__Bacteria|p__Bacteroidota|c__Bacteroidia|o__Bacteroidales|f__Prevotellaceae|g__Prevotella
-bsdb:1086/9/2_Phenylketonuria:Control-(CTRL-SP)_vs_Control-(CTRL-S)_DOWN	NA	k__Bacteria|p__Pseudomonadota|c__Gammaproteobacteria|o__Pasteurellales|f__Pasteurellaceae|g__Aggregatibacter	k__Bacteria|p__Actinomycetota|c__Actinomycetes|o__Propionibacteriales|f__Propionibacteriaceae|g__Arachnia	k__Bacteria|p__Campylobacterota|c__Epsilonproteobacteria|o__Campylobacterales|f__Campylobacteraceae|g__Campylobacter	k__Bacteria|p__Bacteroidota|c__Flavobacteriia|o__Flavobacteriales|f__Flavobacteriaceae|g__Capnocytophaga	k__Bacteria|p__Pseudomonadota|c__Gammaproteobacteria|o__Cardiobacteriales|f__Cardiobacteriaceae|g__Cardiobacterium	k__Bacteria|p__Actinomycetota|c__Actinomycetes|o__Mycobacteriales|f__Corynebacteriaceae|g__Corynebacterium	k__Bacteria|p__Fusobacteriota|c__Fusobacteriia|o__Fusobacteriales|f__Fusobacteriaceae|g__Fusobacterium	k__Bacteria|p__Pseudomonadota|c__Betaproteobacteria|o__Neisseriales|f__Neisseriaceae|g__Kingella	k__Bacteria|p__Fusobacteriota|c__Fusobacteriia|o__Fusobacteriales|f__Leptotrichiaceae|g__Leptotrichia	k__Bacteria|p__Actinomycetota|c__Coriobacteriia|o__Coriobacteriales|f__Atopobiaceae|g__Olsenella	k__Bacteria|p__Bacillota|c__Negativicutes|o__Selenomonadales|f__Selenomonadaceae|g__Selenomonas	k__Bacteria|p__Bacteroidota|c__Bacteroidia|o__Bacteroidales|f__Tannerellaceae|g__Tannerella
-bsdb:1086/10/1_Phenylketonuria:Control-Adults-(CTRL-SP)_vs_Control-Adults-(CTRL-S)_UP	NA	k__Bacteria|p__Bacillota|c__Negativicutes|o__Veillonellales|f__Veillonellaceae|g__Veillonella	k__Bacteria|p__Bacillota|c__Bacilli|o__Lactobacillales|f__Streptococcaceae|g__Streptococcus	k__Bacteria|p__Bacillota|c__Clostridia|o__Lachnospirales|f__Lachnospiraceae|g__Stomatobaculum	k__Bacteria|p__Bacillota|c__Clostridia|o__Peptostreptococcales|f__Peptostreptococcaceae|g__Peptostreptococcus	k__Bacteria|p__Pseudomonadota|c__Gammaproteobacteria|o__Pasteurellales|f__Pasteurellaceae|g__Haemophilus	k__Bacteria|p__Bacillota|c__Bacilli|o__Bacillales|f__Gemellaceae|g__Gemella	k__Bacteria|p__Actinomycetota|c__Coriobacteriia|o__Coriobacteriales|f__Atopobiaceae|g__Atopobium	k__Bacteria|p__Bacteroidota|c__Bacteroidia|o__Bacteroidales|f__Prevotellaceae|g__Alloprevotella	k__Bacteria|p__Pseudomonadota|c__Betaproteobacteria|o__Neisseriales|f__Neisseriaceae|g__Neisseria	k__Bacteria|p__Bacteroidota|c__Bacteroidia|o__Bacteroidales|f__Porphyromonadaceae|g__Porphyromonas	k__Bacteria|p__Bacillota|c__Clostridia|o__Lachnospirales|f__Lachnospiraceae|g__Oribacterium	k__Bacteria|p__Bacteroidota|c__Bacteroidia|o__Bacteroidales|f__Prevotellaceae|g__Prevotella
-bsdb:1086/10/2_Phenylketonuria:Control-Adults-(CTRL-SP)_vs_Control-Adults-(CTRL-S)_DOWN	NA	k__Bacteria|p__Pseudomonadota|c__Gammaproteobacteria|o__Pasteurellales|f__Pasteurellaceae|g__Aggregatibacter	k__Bacteria|p__Actinomycetota|c__Actinomycetes|o__Propionibacteriales|f__Propionibacteriaceae|g__Arachnia	k__Bacteria|p__Campylobacterota|c__Epsilonproteobacteria|o__Campylobacterales|f__Campylobacteraceae|g__Campylobacter	k__Bacteria|p__Bacteroidota|c__Flavobacteriia|o__Flavobacteriales|f__Flavobacteriaceae|g__Capnocytophaga	k__Bacteria|p__Pseudomonadota|c__Gammaproteobacteria|o__Cardiobacteriales|f__Cardiobacteriaceae|g__Cardiobacterium	k__Bacteria|p__Actinomycetota|c__Actinomycetes|o__Mycobacteriales|f__Corynebacteriaceae|g__Corynebacterium	k__Bacteria|p__Fusobacteriota|c__Fusobacteriia|o__Fusobacteriales|f__Fusobacteriaceae|g__Fusobacterium	k__Bacteria|p__Pseudomonadota|c__Betaproteobacteria|o__Neisseriales|f__Neisseriaceae|g__Kingella	k__Bacteria|p__Actinomycetota|c__Coriobacteriia|o__Coriobacteriales|f__Atopobiaceae|g__Olsenella	k__Bacteria|p__Bacillota|c__Negativicutes|o__Selenomonadales|f__Selenomonadaceae|g__Selenomonas	k__Bacteria|p__Bacteroidota|c__Bacteroidia|o__Bacteroidales|f__Tannerellaceae|g__Tannerella
+bsdb:1086/8/1_Phenylketonuria:ChPKU-S-(PKU-children-saliva)-patients_vs_ChCtrlRel-S-[related-control-children-saliva-(Healthy-siblings-of-PKU-patients)]_UP	NA	k__Bacteria|p__Bacteroidota|c__Flavobacteriia|o__Flavobacteriales|f__Flavobacteriaceae|g__Capnocytophaga	k__Bacteria|p__Bacillota|c__Clostridia|o__Peptostreptococcales|f__Peptostreptococcaceae|g__Peptostreptococcus	k__Bacteria|p__Bacillota|c__Clostridia|o__Eubacteriales|f__Peptococcaceae|g__Peptococcus	k__Bacteria|p__Fusobacteriota|c__Fusobacteriia|o__Fusobacteriales|f__Leptotrichiaceae|g__Leptotrichia	k__Bacteria|p__Bacillota|c__Clostridia|o__Lachnospirales|f__Lachnospiraceae|g__Lachnoanaerobaculum	k__Bacteria|p__Bacteroidota|c__Bacteroidia|o__Bacteroidales|f__Porphyromonadaceae|g__Porphyromonas	k__Bacteria|p__Pseudomonadota|c__Gammaproteobacteria|o__Pasteurellales|f__Pasteurellaceae|g__Aggregatibacter
+bsdb:1086/8/2_Phenylketonuria:ChPKU-S-(PKU-children-saliva)-patients_vs_ChCtrlRel-S-[related-control-children-saliva-(Healthy-siblings-of-PKU-patients)]_DOWN	NA	k__Bacteria|p__Actinomycetota|c__Coriobacteriia|o__Coriobacteriales|f__Atopobiaceae|g__Olsenella	k__Bacteria|p__Bacillota|c__Negativicutes|o__Selenomonadales|f__Selenomonadaceae|g__Selenomonas	k__Bacteria|p__Actinomycetota|c__Coriobacteriia|o__Coriobacteriales|f__Atopobiaceae|g__Atopobium	k__Bacteria|p__Actinomycetota|c__Actinomycetes|o__Actinomycetales|f__Actinomycetaceae|g__Actinomyces	k__Bacteria|p__Synergistota|c__Synergistia|o__Synergistales|f__Aminobacteriaceae|g__Fretibacterium
+bsdb:1086/9/1_Phenylketonuria:Control-Subgingival-plaque-(Ctrl-SP)-patients_vs_Control-Saliva-(Ctrl-S)-patients_UP	NA	k__Bacteria|k__Pseudomonadati|p__Bacteroidota|c__Bacteroidia|o__Bacteroidales|f__Prevotellaceae|g__Alloprevotella	k__Bacteria|k__Bacillati|p__Actinomycetota|c__Coriobacteriia|o__Coriobacteriales|f__Atopobiaceae|g__Atopobium	k__Bacteria|k__Bacillati|p__Bacillota|c__Bacilli|o__Bacillales|f__Gemellaceae|g__Gemella	k__Bacteria|k__Pseudomonadati|p__Pseudomonadota|c__Gammaproteobacteria|o__Pasteurellales|f__Pasteurellaceae|g__Haemophilus	k__Bacteria|k__Pseudomonadati|p__Pseudomonadota|c__Betaproteobacteria|o__Neisseriales|f__Neisseriaceae|g__Neisseria	k__Bacteria|k__Bacillati|p__Bacillota|c__Clostridia|o__Lachnospirales|f__Lachnospiraceae|g__Oribacterium	k__Bacteria|k__Bacillati|p__Bacillota|c__Clostridia|o__Peptostreptococcales|f__Peptostreptococcaceae|g__Peptostreptococcus	k__Bacteria|k__Pseudomonadati|p__Bacteroidota|c__Bacteroidia|o__Bacteroidales|f__Porphyromonadaceae|g__Porphyromonas	k__Bacteria|k__Pseudomonadati|p__Bacteroidota|c__Bacteroidia|o__Bacteroidales|f__Prevotellaceae|g__Prevotella	k__Bacteria|k__Bacillati|p__Bacillota|c__Clostridia|o__Lachnospirales|f__Lachnospiraceae|g__Stomatobaculum	k__Bacteria|k__Bacillati|p__Bacillota|c__Bacilli|o__Lactobacillales|f__Streptococcaceae|g__Streptococcus	k__Bacteria|k__Bacillati|p__Bacillota|c__Negativicutes|o__Veillonellales|f__Veillonellaceae|g__Veillonella	k__Eukaryota|k__Viridiplantae|p__Streptophyta|c__Magnoliopsida|o__Fabales|f__Fabaceae|s__Papilionoideae|g__Rothia	k__Bacteria|k__Bacillati|p__Bacillota|c__Clostridia|o__Lachnospirales|f__Lachnospiraceae|g__Lachnoanaerobaculum
+bsdb:1086/9/2_Phenylketonuria:Control-Subgingival-plaque-(Ctrl-SP)-patients_vs_Control-Saliva-(Ctrl-S)-patients_DOWN	NA	k__Bacteria|k__Pseudomonadati|p__Pseudomonadota|c__Gammaproteobacteria|o__Pasteurellales|f__Pasteurellaceae|g__Aggregatibacter	k__Bacteria|k__Bacillati|p__Actinomycetota|c__Actinomycetes|o__Propionibacteriales|f__Propionibacteriaceae|g__Arachnia	k__Bacteria|k__Pseudomonadati|p__Campylobacterota|c__Epsilonproteobacteria|o__Campylobacterales|f__Campylobacteraceae|g__Campylobacter	k__Bacteria|k__Pseudomonadati|p__Bacteroidota|c__Flavobacteriia|o__Flavobacteriales|f__Flavobacteriaceae|g__Capnocytophaga	k__Bacteria|k__Pseudomonadati|p__Pseudomonadota|c__Gammaproteobacteria|o__Cardiobacteriales|f__Cardiobacteriaceae|g__Cardiobacterium	k__Bacteria|k__Bacillati|p__Actinomycetota|c__Actinomycetes|o__Mycobacteriales|f__Corynebacteriaceae|g__Corynebacterium	k__Bacteria|k__Fusobacteriati|p__Fusobacteriota|c__Fusobacteriia|o__Fusobacteriales|f__Fusobacteriaceae|g__Fusobacterium	k__Bacteria|k__Pseudomonadati|p__Pseudomonadota|c__Betaproteobacteria|o__Neisseriales|f__Neisseriaceae|g__Kingella	k__Bacteria|k__Fusobacteriati|p__Fusobacteriota|c__Fusobacteriia|o__Fusobacteriales|f__Leptotrichiaceae|g__Leptotrichia	k__Bacteria|k__Bacillati|p__Actinomycetota|c__Coriobacteriia|o__Coriobacteriales|f__Atopobiaceae|g__Olsenella	k__Bacteria|k__Bacillati|p__Bacillota|c__Negativicutes|o__Selenomonadales|f__Selenomonadaceae|g__Selenomonas	k__Bacteria|k__Pseudomonadati|p__Bacteroidota|c__Bacteroidia|o__Bacteroidales|f__Tannerellaceae|g__Tannerella
+bsdb:1086/10/1_Phenylketonuria:Control-Adults-Subgingival-plaque-(Ctrl-Adults-SP)-patients_vs_Control-Adults-Saliva-(Ctrl-Adults-S)-patients_UP	NA	k__Bacteria|k__Pseudomonadati|p__Bacteroidota|c__Bacteroidia|o__Bacteroidales|f__Prevotellaceae|g__Alloprevotella	k__Bacteria|k__Bacillati|p__Actinomycetota|c__Coriobacteriia|o__Coriobacteriales|f__Atopobiaceae|g__Atopobium	k__Bacteria|k__Bacillati|p__Bacillota|c__Bacilli|o__Bacillales|f__Gemellaceae|g__Gemella	k__Bacteria|k__Pseudomonadati|p__Pseudomonadota|c__Gammaproteobacteria|o__Pasteurellales|f__Pasteurellaceae|g__Haemophilus	k__Bacteria|k__Pseudomonadati|p__Pseudomonadota|c__Betaproteobacteria|o__Neisseriales|f__Neisseriaceae|g__Neisseria	k__Bacteria|k__Bacillati|p__Bacillota|c__Clostridia|o__Lachnospirales|f__Lachnospiraceae|g__Oribacterium	k__Bacteria|k__Bacillati|p__Bacillota|c__Clostridia|o__Peptostreptococcales|f__Peptostreptococcaceae|g__Peptostreptococcus	k__Bacteria|k__Pseudomonadati|p__Bacteroidota|c__Bacteroidia|o__Bacteroidales|f__Porphyromonadaceae|g__Porphyromonas	k__Bacteria|k__Pseudomonadati|p__Bacteroidota|c__Bacteroidia|o__Bacteroidales|f__Prevotellaceae|g__Prevotella	k__Bacteria|k__Bacillati|p__Bacillota|c__Clostridia|o__Lachnospirales|f__Lachnospiraceae|g__Stomatobaculum	k__Bacteria|k__Bacillati|p__Bacillota|c__Bacilli|o__Lactobacillales|f__Streptococcaceae|g__Streptococcus	k__Bacteria|k__Bacillati|p__Bacillota|c__Negativicutes|o__Veillonellales|f__Veillonellaceae|g__Veillonella	k__Eukaryota|k__Viridiplantae|p__Streptophyta|c__Magnoliopsida|o__Fabales|f__Fabaceae|s__Papilionoideae|g__Rothia
+bsdb:1086/10/2_Phenylketonuria:Control-Adults-Subgingival-plaque-(Ctrl-Adults-SP)-patients_vs_Control-Adults-Saliva-(Ctrl-Adults-S)-patients_DOWN	NA	k__Bacteria|k__Pseudomonadati|p__Pseudomonadota|c__Gammaproteobacteria|o__Pasteurellales|f__Pasteurellaceae|g__Aggregatibacter	k__Bacteria|k__Bacillati|p__Actinomycetota|c__Actinomycetes|o__Propionibacteriales|f__Propionibacteriaceae|g__Arachnia	k__Bacteria|k__Pseudomonadati|p__Campylobacterota|c__Epsilonproteobacteria|o__Campylobacterales|f__Campylobacteraceae|g__Campylobacter	k__Bacteria|k__Pseudomonadati|p__Bacteroidota|c__Flavobacteriia|o__Flavobacteriales|f__Flavobacteriaceae|g__Capnocytophaga	k__Bacteria|k__Pseudomonadati|p__Pseudomonadota|c__Gammaproteobacteria|o__Cardiobacteriales|f__Cardiobacteriaceae|g__Cardiobacterium	k__Bacteria|k__Bacillati|p__Actinomycetota|c__Actinomycetes|o__Mycobacteriales|f__Corynebacteriaceae|g__Corynebacterium	k__Bacteria|k__Fusobacteriati|p__Fusobacteriota|c__Fusobacteriia|o__Fusobacteriales|f__Fusobacteriaceae|g__Fusobacterium	k__Bacteria|k__Pseudomonadati|p__Pseudomonadota|c__Betaproteobacteria|o__Neisseriales|f__Neisseriaceae|g__Kingella	k__Bacteria|k__Bacillati|p__Actinomycetota|c__Coriobacteriia|o__Coriobacteriales|f__Atopobiaceae|g__Olsenella	k__Bacteria|k__Bacillati|p__Bacillota|c__Negativicutes|o__Selenomonadales|f__Selenomonadaceae|g__Selenomonas	k__Bacteria|k__Pseudomonadati|p__Bacteroidota|c__Bacteroidia|o__Bacteroidales|f__Tannerellaceae|g__Tannerella
 bsdb:1086/11/1_Phenylketonuria:Control-Children-(CTRL-Ch-SP)_vs_Control-Children-(CTRL-Ch-S)_UP	NA	k__Bacteria|p__Bacteroidota|c__Bacteroidia|o__Bacteroidales|f__Prevotellaceae|g__Prevotella	k__Bacteria|p__Bacillota|c__Clostridia|o__Lachnospirales|f__Lachnospiraceae|g__Oribacterium	k__Bacteria|p__Bacteroidota|c__Bacteroidia|o__Bacteroidales|f__Porphyromonadaceae|g__Porphyromonas	k__Bacteria|p__Pseudomonadota|c__Betaproteobacteria|o__Neisseriales|f__Neisseriaceae|g__Neisseria	k__Bacteria|p__Bacteroidota|c__Bacteroidia|o__Bacteroidales|f__Prevotellaceae|g__Alloprevotella	k__Bacteria|p__Actinomycetota|c__Coriobacteriia|o__Coriobacteriales|f__Atopobiaceae|g__Atopobium	k__Bacteria|p__Bacillota|c__Bacilli|o__Bacillales|f__Gemellaceae|g__Gemella	k__Bacteria|p__Pseudomonadota|c__Gammaproteobacteria|o__Pasteurellales|f__Pasteurellaceae|g__Haemophilus	k__Bacteria|p__Bacillota|c__Clostridia|o__Peptostreptococcales|f__Peptostreptococcaceae|g__Peptostreptococcus	k__Bacteria|p__Bacillota|c__Clostridia|o__Lachnospirales|f__Lachnospiraceae|g__Stomatobaculum	k__Bacteria|p__Bacillota|c__Bacilli|o__Lactobacillales|f__Streptococcaceae|g__Streptococcus	k__Bacteria|p__Bacillota|c__Negativicutes|o__Veillonellales|f__Veillonellaceae|g__Veillonella
 bsdb:1086/11/2_Phenylketonuria:Control-Children-(CTRL-Ch-SP)_vs_Control-Children-(CTRL-Ch-S)_DOWN	NA	k__Bacteria|p__Bacteroidota|c__Flavobacteriia|o__Flavobacteriales|f__Flavobacteriaceae|g__Capnocytophaga	k__Bacteria|p__Fusobacteriota|c__Fusobacteriia|o__Fusobacteriales|f__Fusobacteriaceae|g__Fusobacterium	k__Bacteria|p__Actinomycetota|c__Actinomycetes|o__Mycobacteriales|f__Corynebacteriaceae|g__Corynebacterium	k__Bacteria|p__Pseudomonadota|c__Betaproteobacteria|o__Neisseriales|f__Neisseriaceae|g__Kingella	k__Bacteria|p__Actinomycetota|c__Actinomycetes|o__Propionibacteriales|f__Propionibacteriaceae|g__Arachnia	k__Bacteria|p__Pseudomonadota|c__Gammaproteobacteria|o__Cardiobacteriales|f__Cardiobacteriaceae|g__Cardiobacterium	k__Bacteria|p__Actinomycetota|c__Coriobacteriia|o__Coriobacteriales|f__Atopobiaceae|g__Olsenella	k__Bacteria|p__Bacteroidota|c__Bacteroidia|o__Bacteroidales|f__Tannerellaceae|g__Tannerella	k__Bacteria|p__Campylobacterota|c__Epsilonproteobacteria|o__Campylobacterales|f__Campylobacteraceae|g__Campylobacter	k__Bacteria|p__Synergistota|c__Synergistia|o__Synergistales|f__Aminobacteriaceae|g__Fretibacterium
 bsdb:1086/12/1_Phenylketonuria:Phenylketonuria-(PKU-SP)_vs_Phenylketonuria-(PKU-S)_UP	NA	k__Bacteria|p__Bacteroidota|c__Bacteroidia|o__Bacteroidales|f__Prevotellaceae|g__Alloprevotella	k__Bacteria|p__Actinomycetota|c__Coriobacteriia|o__Coriobacteriales|f__Atopobiaceae|g__Atopobium	k__Bacteria|p__Bacillota|c__Bacilli|o__Bacillales|f__Gemellaceae|g__Gemella	k__Bacteria|p__Pseudomonadota|c__Gammaproteobacteria|o__Pasteurellales|f__Pasteurellaceae|g__Haemophilus	k__Bacteria|p__Bacillota|c__Clostridia|o__Lachnospirales|f__Lachnospiraceae|g__Lachnoanaerobaculum	k__Bacteria|p__Pseudomonadota|c__Betaproteobacteria|o__Neisseriales|f__Neisseriaceae|g__Neisseria	k__Bacteria|p__Bacillota|c__Clostridia|o__Lachnospirales|f__Lachnospiraceae|g__Oribacterium	k__Bacteria|p__Bacillota|c__Clostridia|o__Peptostreptococcales|f__Peptostreptococcaceae|g__Peptostreptococcus	k__Bacteria|p__Bacteroidota|c__Bacteroidia|o__Bacteroidales|f__Porphyromonadaceae|g__Porphyromonas	k__Bacteria|p__Bacteroidota|c__Bacteroidia|o__Bacteroidales|f__Prevotellaceae|g__Prevotella	k__Eukaryota|k__Viridiplantae|p__Streptophyta|c__Magnoliopsida|o__Fabales|f__Fabaceae|s__Papilionoideae|g__Rothia	k__Bacteria|p__Bacillota|c__Clostridia|o__Lachnospirales|f__Lachnospiraceae|g__Stomatobaculum	k__Bacteria|p__Bacillota|c__Bacilli|o__Lactobacillales|f__Streptococcaceae|g__Streptococcus	k__Bacteria|p__Bacillota|c__Negativicutes|o__Veillonellales|f__Veillonellaceae|g__Veillonella
diff --git a/bugsigdb_signatures_genus_ncbi.gmt b/bugsigdb_signatures_genus_ncbi.gmt
index ee1750af3..73203dde7 100644
--- a/bugsigdb_signatures_genus_ncbi.gmt
+++ b/bugsigdb_signatures_genus_ncbi.gmt
@@ -1,4 +1,4 @@
-# BugSigDB 2025-01-14_11:58_UTC, License: Creative Commons Attribution 4.0 International, URL: https://bugsigdb.org
+# BugSigDB 2025-01-14_13:02_UTC, License: Creative Commons Attribution 4.0 International, URL: https://bugsigdb.org
 bsdb:1/1/1_Colorectal-adenoma:conventional-adenoma-cases_vs_controls_UP	NA	1654	1716	1301	162289	189330	33024	40544	2759736	1386
 bsdb:1/1/2_Colorectal-adenoma:conventional-adenoma-cases_vs_controls_DOWN	NA	100883
 bsdb:1/2/1_Hyperplastic-Polyp:hyperplastic-polyp-cases_vs_controls_UP	NA	207244	2759736
@@ -4570,12 +4570,12 @@ bsdb:1086/6/1_Phenylketonuria:Phenylketonuria-Children-subgingival-plaque-(PKU-C
 bsdb:1086/6/2_Phenylketonuria:Phenylketonuria-Children-subgingival-plaque-(PKU-Ch-SP)-patients_vs_Control-Children-subgingival-plaque-(Ctrl-Ch-SP)-patients_DOWN	NA	416916	1016	1378	32067
 bsdb:1086/7/1_Phenylketonuria:ChCtrlUnrel-S-(unrelated-control-children-saliva)-patients_vs_ChCtrlRel-S-[related-control-children-saliva-(Healthy-siblings-of-PKU-patients)]_UP	NA	724	1164882	265975
 bsdb:1086/7/2_Phenylketonuria:ChCtrlUnrel-S-(unrelated-control-children-saliva)-patients_vs_ChCtrlRel-S-[related-control-children-saliva-(Healthy-siblings-of-PKU-patients)]_DOWN	NA	1654	2801844	1380	1434006	47670	1257
-bsdb:1086/8/1_Phenylketonuria:Ch-PKU-(PKU-children)_vs_Ch-CTRL-rel-(Healthy-siblings-of-PKU-patients)_UP	NA	1016	1257	2740	32067	1164882	836	416916
-bsdb:1086/8/2_Phenylketonuria:Ch-PKU-(PKU-children)_vs_Ch-CTRL-rel-(Healthy-siblings-of-PKU-patients)_DOWN	NA	133925	970	1380	1654	1434006
-bsdb:1086/9/1_Phenylketonuria:Control-(CTRL-SP)_vs_Control-(CTRL-S)_UP	NA	29465	1301	1213720	1257	724	1378	1380	1283313	482	836	265975	838
-bsdb:1086/9/2_Phenylketonuria:Control-(CTRL-SP)_vs_Control-(CTRL-S)_DOWN	NA	416916	2801844	194	1016	2717	1716	848	32257	32067	133925	970	195950
-bsdb:1086/10/1_Phenylketonuria:Control-Adults-(CTRL-SP)_vs_Control-Adults-(CTRL-S)_UP	NA	29465	1301	1213720	1257	724	1378	1380	1283313	482	836	265975	838
-bsdb:1086/10/2_Phenylketonuria:Control-Adults-(CTRL-SP)_vs_Control-Adults-(CTRL-S)_DOWN	NA	416916	2801844	194	1016	2717	1716	848	32257	133925	970	195950
+bsdb:1086/8/1_Phenylketonuria:ChPKU-S-(PKU-children-saliva)-patients_vs_ChCtrlRel-S-[related-control-children-saliva-(Healthy-siblings-of-PKU-patients)]_UP	NA	1016	1257	2740	32067	1164882	836	416916
+bsdb:1086/8/2_Phenylketonuria:ChPKU-S-(PKU-children-saliva)-patients_vs_ChCtrlRel-S-[related-control-children-saliva-(Healthy-siblings-of-PKU-patients)]_DOWN	NA	133925	970	1380	1654	1434006
+bsdb:1086/9/1_Phenylketonuria:Control-Subgingival-plaque-(Ctrl-SP)-patients_vs_Control-Saliva-(Ctrl-S)-patients_UP	NA	1283313	1380	1378	724	482	265975	1257	836	838	1213720	1301	29465	508215	1164882
+bsdb:1086/9/2_Phenylketonuria:Control-Subgingival-plaque-(Ctrl-SP)-patients_vs_Control-Saliva-(Ctrl-S)-patients_DOWN	NA	416916	2801844	194	1016	2717	1716	848	32257	32067	133925	970	195950
+bsdb:1086/10/1_Phenylketonuria:Control-Adults-Subgingival-plaque-(Ctrl-Adults-SP)-patients_vs_Control-Adults-Saliva-(Ctrl-Adults-S)-patients_UP	NA	1283313	1380	1378	724	482	265975	1257	836	838	1213720	1301	29465	508215
+bsdb:1086/10/2_Phenylketonuria:Control-Adults-Subgingival-plaque-(Ctrl-Adults-SP)-patients_vs_Control-Adults-Saliva-(Ctrl-Adults-S)-patients_DOWN	NA	416916	2801844	194	1016	2717	1716	848	32257	133925	970	195950
 bsdb:1086/11/1_Phenylketonuria:Control-Children-(CTRL-Ch-SP)_vs_Control-Children-(CTRL-Ch-S)_UP	NA	838	265975	836	482	1283313	1380	1378	724	1257	1213720	1301	29465
 bsdb:1086/11/2_Phenylketonuria:Control-Children-(CTRL-Ch-SP)_vs_Control-Children-(CTRL-Ch-S)_DOWN	NA	1016	848	1716	32257	2801844	2717	133925	195950	194	1434006
 bsdb:1086/12/1_Phenylketonuria:Phenylketonuria-(PKU-SP)_vs_Phenylketonuria-(PKU-S)_UP	NA	1283313	1380	1378	724	1164882	482	265975	1257	836	838	508215	1213720	1301	29465
diff --git a/bugsigdb_signatures_genus_ncbi_exact.gmt b/bugsigdb_signatures_genus_ncbi_exact.gmt
index 8bcda0a55..6fd1b4ff2 100644
--- a/bugsigdb_signatures_genus_ncbi_exact.gmt
+++ b/bugsigdb_signatures_genus_ncbi_exact.gmt
@@ -1,4 +1,4 @@
-# BugSigDB 2025-01-14_11:58_UTC, License: Creative Commons Attribution 4.0 International, URL: https://bugsigdb.org
+# BugSigDB 2025-01-14_13:02_UTC, License: Creative Commons Attribution 4.0 International, URL: https://bugsigdb.org
 bsdb:1/1/1_Colorectal-adenoma:conventional-adenoma-cases_vs_controls_UP	NA	1654	1716	1301	162289	189330	33024	40544	1386
 bsdb:1/1/2_Colorectal-adenoma:conventional-adenoma-cases_vs_controls_DOWN	NA	100883
 bsdb:1/2/1_Hyperplastic-Polyp:hyperplastic-polyp-cases_vs_controls_UP	NA	207244
@@ -3825,12 +3825,12 @@ bsdb:1086/6/1_Phenylketonuria:Phenylketonuria-Children-subgingival-plaque-(PKU-C
 bsdb:1086/6/2_Phenylketonuria:Phenylketonuria-Children-subgingival-plaque-(PKU-Ch-SP)-patients_vs_Control-Children-subgingival-plaque-(Ctrl-Ch-SP)-patients_DOWN	NA	416916	1016	1378	32067
 bsdb:1086/7/1_Phenylketonuria:ChCtrlUnrel-S-(unrelated-control-children-saliva)-patients_vs_ChCtrlRel-S-[related-control-children-saliva-(Healthy-siblings-of-PKU-patients)]_UP	NA	724	1164882	265975
 bsdb:1086/7/2_Phenylketonuria:ChCtrlUnrel-S-(unrelated-control-children-saliva)-patients_vs_ChCtrlRel-S-[related-control-children-saliva-(Healthy-siblings-of-PKU-patients)]_DOWN	NA	1654	2801844	1380	1434006	47670	1257
-bsdb:1086/8/1_Phenylketonuria:Ch-PKU-(PKU-children)_vs_Ch-CTRL-rel-(Healthy-siblings-of-PKU-patients)_UP	NA	1016	1257	2740	32067	1164882	836	416916
-bsdb:1086/8/2_Phenylketonuria:Ch-PKU-(PKU-children)_vs_Ch-CTRL-rel-(Healthy-siblings-of-PKU-patients)_DOWN	NA	133925	970	1380	1654	1434006
-bsdb:1086/9/1_Phenylketonuria:Control-(CTRL-SP)_vs_Control-(CTRL-S)_UP	NA	29465	1301	1213720	1257	724	1378	1380	1283313	482	836	265975	838
-bsdb:1086/9/2_Phenylketonuria:Control-(CTRL-SP)_vs_Control-(CTRL-S)_DOWN	NA	416916	2801844	194	1016	2717	1716	848	32257	32067	133925	970	195950
-bsdb:1086/10/1_Phenylketonuria:Control-Adults-(CTRL-SP)_vs_Control-Adults-(CTRL-S)_UP	NA	29465	1301	1213720	1257	724	1378	1380	1283313	482	836	265975	838
-bsdb:1086/10/2_Phenylketonuria:Control-Adults-(CTRL-SP)_vs_Control-Adults-(CTRL-S)_DOWN	NA	416916	2801844	194	1016	2717	1716	848	32257	133925	970	195950
+bsdb:1086/8/1_Phenylketonuria:ChPKU-S-(PKU-children-saliva)-patients_vs_ChCtrlRel-S-[related-control-children-saliva-(Healthy-siblings-of-PKU-patients)]_UP	NA	1016	1257	2740	32067	1164882	836	416916
+bsdb:1086/8/2_Phenylketonuria:ChPKU-S-(PKU-children-saliva)-patients_vs_ChCtrlRel-S-[related-control-children-saliva-(Healthy-siblings-of-PKU-patients)]_DOWN	NA	133925	970	1380	1654	1434006
+bsdb:1086/9/1_Phenylketonuria:Control-Subgingival-plaque-(Ctrl-SP)-patients_vs_Control-Saliva-(Ctrl-S)-patients_UP	NA	1283313	1380	1378	724	482	265975	1257	836	838	1213720	1301	29465	508215	1164882
+bsdb:1086/9/2_Phenylketonuria:Control-Subgingival-plaque-(Ctrl-SP)-patients_vs_Control-Saliva-(Ctrl-S)-patients_DOWN	NA	416916	2801844	194	1016	2717	1716	848	32257	32067	133925	970	195950
+bsdb:1086/10/1_Phenylketonuria:Control-Adults-Subgingival-plaque-(Ctrl-Adults-SP)-patients_vs_Control-Adults-Saliva-(Ctrl-Adults-S)-patients_UP	NA	1283313	1380	1378	724	482	265975	1257	836	838	1213720	1301	29465	508215
+bsdb:1086/10/2_Phenylketonuria:Control-Adults-Subgingival-plaque-(Ctrl-Adults-SP)-patients_vs_Control-Adults-Saliva-(Ctrl-Adults-S)-patients_DOWN	NA	416916	2801844	194	1016	2717	1716	848	32257	133925	970	195950
 bsdb:1086/11/1_Phenylketonuria:Control-Children-(CTRL-Ch-SP)_vs_Control-Children-(CTRL-Ch-S)_UP	NA	838	265975	836	482	1283313	1380	1378	724	1257	1213720	1301	29465
 bsdb:1086/11/2_Phenylketonuria:Control-Children-(CTRL-Ch-SP)_vs_Control-Children-(CTRL-Ch-S)_DOWN	NA	1016	848	1716	32257	2801844	2717	133925	195950	194	1434006
 bsdb:1086/12/1_Phenylketonuria:Phenylketonuria-(PKU-SP)_vs_Phenylketonuria-(PKU-S)_UP	NA	1283313	1380	1378	724	1164882	482	265975	1257	836	838	508215	1213720	1301	29465
diff --git a/bugsigdb_signatures_genus_taxname.gmt b/bugsigdb_signatures_genus_taxname.gmt
index c739cdc44..201c4fe6c 100644
--- a/bugsigdb_signatures_genus_taxname.gmt
+++ b/bugsigdb_signatures_genus_taxname.gmt
@@ -1,4 +1,4 @@
-# BugSigDB 2025-01-14_11:58_UTC, License: Creative Commons Attribution 4.0 International, URL: https://bugsigdb.org
+# BugSigDB 2025-01-14_13:02_UTC, License: Creative Commons Attribution 4.0 International, URL: https://bugsigdb.org
 bsdb:1/1/1_Colorectal-adenoma:conventional-adenoma-cases_vs_controls_UP	NA	Actinomyces	Corynebacterium	Streptococcus	Peptoniphilus	Dorea	Phascolarctobacterium	Sutterella	Lacticaseibacillus	Bacillus
 bsdb:1/1/2_Colorectal-adenoma:conventional-adenoma-cases_vs_controls_DOWN	NA	Coprobacillus
 bsdb:1/2/1_Hyperplastic-Polyp:hyperplastic-polyp-cases_vs_controls_UP	NA	Anaerostipes	Lacticaseibacillus
@@ -4570,12 +4570,12 @@ bsdb:1086/6/1_Phenylketonuria:Phenylketonuria-Children-subgingival-plaque-(PKU-C
 bsdb:1086/6/2_Phenylketonuria:Phenylketonuria-Children-subgingival-plaque-(PKU-Ch-SP)-patients_vs_Control-Children-subgingival-plaque-(Ctrl-Ch-SP)-patients_DOWN	NA	Aggregatibacter	Capnocytophaga	Gemella	Leptotrichia
 bsdb:1086/7/1_Phenylketonuria:ChCtrlUnrel-S-(unrelated-control-children-saliva)-patients_vs_ChCtrlRel-S-[related-control-children-saliva-(Healthy-siblings-of-PKU-patients)]_UP	NA	Haemophilus	Lachnoanaerobaculum	Oribacterium
 bsdb:1086/7/2_Phenylketonuria:ChCtrlUnrel-S-(unrelated-control-children-saliva)-patients_vs_ChCtrlRel-S-[related-control-children-saliva-(Healthy-siblings-of-PKU-patients)]_DOWN	NA	Actinomyces	Arachnia	Atopobium	Fretibacterium	Lautropia	Peptostreptococcus
-bsdb:1086/8/1_Phenylketonuria:Ch-PKU-(PKU-children)_vs_Ch-CTRL-rel-(Healthy-siblings-of-PKU-patients)_UP	NA	Capnocytophaga	Peptostreptococcus	Peptococcus	Leptotrichia	Lachnoanaerobaculum	Porphyromonas	Aggregatibacter
-bsdb:1086/8/2_Phenylketonuria:Ch-PKU-(PKU-children)_vs_Ch-CTRL-rel-(Healthy-siblings-of-PKU-patients)_DOWN	NA	Olsenella	Selenomonas	Atopobium	Actinomyces	Fretibacterium
-bsdb:1086/9/1_Phenylketonuria:Control-(CTRL-SP)_vs_Control-(CTRL-S)_UP	NA	Veillonella	Streptococcus	Stomatobaculum	Peptostreptococcus	Haemophilus	Gemella	Atopobium	Alloprevotella	Neisseria	Porphyromonas	Oribacterium	Prevotella
-bsdb:1086/9/2_Phenylketonuria:Control-(CTRL-SP)_vs_Control-(CTRL-S)_DOWN	NA	Aggregatibacter	Arachnia	Campylobacter	Capnocytophaga	Cardiobacterium	Corynebacterium	Fusobacterium	Kingella	Leptotrichia	Olsenella	Selenomonas	Tannerella
-bsdb:1086/10/1_Phenylketonuria:Control-Adults-(CTRL-SP)_vs_Control-Adults-(CTRL-S)_UP	NA	Veillonella	Streptococcus	Stomatobaculum	Peptostreptococcus	Haemophilus	Gemella	Atopobium	Alloprevotella	Neisseria	Porphyromonas	Oribacterium	Prevotella
-bsdb:1086/10/2_Phenylketonuria:Control-Adults-(CTRL-SP)_vs_Control-Adults-(CTRL-S)_DOWN	NA	Aggregatibacter	Arachnia	Campylobacter	Capnocytophaga	Cardiobacterium	Corynebacterium	Fusobacterium	Kingella	Olsenella	Selenomonas	Tannerella
+bsdb:1086/8/1_Phenylketonuria:ChPKU-S-(PKU-children-saliva)-patients_vs_ChCtrlRel-S-[related-control-children-saliva-(Healthy-siblings-of-PKU-patients)]_UP	NA	Capnocytophaga	Peptostreptococcus	Peptococcus	Leptotrichia	Lachnoanaerobaculum	Porphyromonas	Aggregatibacter
+bsdb:1086/8/2_Phenylketonuria:ChPKU-S-(PKU-children-saliva)-patients_vs_ChCtrlRel-S-[related-control-children-saliva-(Healthy-siblings-of-PKU-patients)]_DOWN	NA	Olsenella	Selenomonas	Atopobium	Actinomyces	Fretibacterium
+bsdb:1086/9/1_Phenylketonuria:Control-Subgingival-plaque-(Ctrl-SP)-patients_vs_Control-Saliva-(Ctrl-S)-patients_UP	NA	Alloprevotella	Atopobium	Gemella	Haemophilus	Neisseria	Oribacterium	Peptostreptococcus	Porphyromonas	Prevotella	Stomatobaculum	Streptococcus	Veillonella	Rothia	Lachnoanaerobaculum
+bsdb:1086/9/2_Phenylketonuria:Control-Subgingival-plaque-(Ctrl-SP)-patients_vs_Control-Saliva-(Ctrl-S)-patients_DOWN	NA	Aggregatibacter	Arachnia	Campylobacter	Capnocytophaga	Cardiobacterium	Corynebacterium	Fusobacterium	Kingella	Leptotrichia	Olsenella	Selenomonas	Tannerella
+bsdb:1086/10/1_Phenylketonuria:Control-Adults-Subgingival-plaque-(Ctrl-Adults-SP)-patients_vs_Control-Adults-Saliva-(Ctrl-Adults-S)-patients_UP	NA	Alloprevotella	Atopobium	Gemella	Haemophilus	Neisseria	Oribacterium	Peptostreptococcus	Porphyromonas	Prevotella	Stomatobaculum	Streptococcus	Veillonella	Rothia
+bsdb:1086/10/2_Phenylketonuria:Control-Adults-Subgingival-plaque-(Ctrl-Adults-SP)-patients_vs_Control-Adults-Saliva-(Ctrl-Adults-S)-patients_DOWN	NA	Aggregatibacter	Arachnia	Campylobacter	Capnocytophaga	Cardiobacterium	Corynebacterium	Fusobacterium	Kingella	Olsenella	Selenomonas	Tannerella
 bsdb:1086/11/1_Phenylketonuria:Control-Children-(CTRL-Ch-SP)_vs_Control-Children-(CTRL-Ch-S)_UP	NA	Prevotella	Oribacterium	Porphyromonas	Neisseria	Alloprevotella	Atopobium	Gemella	Haemophilus	Peptostreptococcus	Stomatobaculum	Streptococcus	Veillonella
 bsdb:1086/11/2_Phenylketonuria:Control-Children-(CTRL-Ch-SP)_vs_Control-Children-(CTRL-Ch-S)_DOWN	NA	Capnocytophaga	Fusobacterium	Corynebacterium	Kingella	Arachnia	Cardiobacterium	Olsenella	Tannerella	Campylobacter	Fretibacterium
 bsdb:1086/12/1_Phenylketonuria:Phenylketonuria-(PKU-SP)_vs_Phenylketonuria-(PKU-S)_UP	NA	Alloprevotella	Atopobium	Gemella	Haemophilus	Lachnoanaerobaculum	Neisseria	Oribacterium	Peptostreptococcus	Porphyromonas	Prevotella	Rothia	Stomatobaculum	Streptococcus	Veillonella
diff --git a/bugsigdb_signatures_genus_taxname_exact.gmt b/bugsigdb_signatures_genus_taxname_exact.gmt
index b6838a54d..7905dd4e0 100644
--- a/bugsigdb_signatures_genus_taxname_exact.gmt
+++ b/bugsigdb_signatures_genus_taxname_exact.gmt
@@ -1,4 +1,4 @@
-# BugSigDB 2025-01-14_11:58_UTC, License: Creative Commons Attribution 4.0 International, URL: https://bugsigdb.org
+# BugSigDB 2025-01-14_13:02_UTC, License: Creative Commons Attribution 4.0 International, URL: https://bugsigdb.org
 bsdb:1/1/1_Colorectal-adenoma:conventional-adenoma-cases_vs_controls_UP	NA	Actinomyces	Corynebacterium	Streptococcus	Peptoniphilus	Dorea	Phascolarctobacterium	Sutterella	Bacillus
 bsdb:1/1/2_Colorectal-adenoma:conventional-adenoma-cases_vs_controls_DOWN	NA	Coprobacillus
 bsdb:1/2/1_Hyperplastic-Polyp:hyperplastic-polyp-cases_vs_controls_UP	NA	Anaerostipes
@@ -3825,12 +3825,12 @@ bsdb:1086/6/1_Phenylketonuria:Phenylketonuria-Children-subgingival-plaque-(PKU-C
 bsdb:1086/6/2_Phenylketonuria:Phenylketonuria-Children-subgingival-plaque-(PKU-Ch-SP)-patients_vs_Control-Children-subgingival-plaque-(Ctrl-Ch-SP)-patients_DOWN	NA	Aggregatibacter	Capnocytophaga	Gemella	Leptotrichia
 bsdb:1086/7/1_Phenylketonuria:ChCtrlUnrel-S-(unrelated-control-children-saliva)-patients_vs_ChCtrlRel-S-[related-control-children-saliva-(Healthy-siblings-of-PKU-patients)]_UP	NA	Haemophilus	Lachnoanaerobaculum	Oribacterium
 bsdb:1086/7/2_Phenylketonuria:ChCtrlUnrel-S-(unrelated-control-children-saliva)-patients_vs_ChCtrlRel-S-[related-control-children-saliva-(Healthy-siblings-of-PKU-patients)]_DOWN	NA	Actinomyces	Arachnia	Atopobium	Fretibacterium	Lautropia	Peptostreptococcus
-bsdb:1086/8/1_Phenylketonuria:Ch-PKU-(PKU-children)_vs_Ch-CTRL-rel-(Healthy-siblings-of-PKU-patients)_UP	NA	Capnocytophaga	Peptostreptococcus	Peptococcus	Leptotrichia	Lachnoanaerobaculum	Porphyromonas	Aggregatibacter
-bsdb:1086/8/2_Phenylketonuria:Ch-PKU-(PKU-children)_vs_Ch-CTRL-rel-(Healthy-siblings-of-PKU-patients)_DOWN	NA	Olsenella	Selenomonas	Atopobium	Actinomyces	Fretibacterium
-bsdb:1086/9/1_Phenylketonuria:Control-(CTRL-SP)_vs_Control-(CTRL-S)_UP	NA	Veillonella	Streptococcus	Stomatobaculum	Peptostreptococcus	Haemophilus	Gemella	Atopobium	Alloprevotella	Neisseria	Porphyromonas	Oribacterium	Prevotella
-bsdb:1086/9/2_Phenylketonuria:Control-(CTRL-SP)_vs_Control-(CTRL-S)_DOWN	NA	Aggregatibacter	Arachnia	Campylobacter	Capnocytophaga	Cardiobacterium	Corynebacterium	Fusobacterium	Kingella	Leptotrichia	Olsenella	Selenomonas	Tannerella
-bsdb:1086/10/1_Phenylketonuria:Control-Adults-(CTRL-SP)_vs_Control-Adults-(CTRL-S)_UP	NA	Veillonella	Streptococcus	Stomatobaculum	Peptostreptococcus	Haemophilus	Gemella	Atopobium	Alloprevotella	Neisseria	Porphyromonas	Oribacterium	Prevotella
-bsdb:1086/10/2_Phenylketonuria:Control-Adults-(CTRL-SP)_vs_Control-Adults-(CTRL-S)_DOWN	NA	Aggregatibacter	Arachnia	Campylobacter	Capnocytophaga	Cardiobacterium	Corynebacterium	Fusobacterium	Kingella	Olsenella	Selenomonas	Tannerella
+bsdb:1086/8/1_Phenylketonuria:ChPKU-S-(PKU-children-saliva)-patients_vs_ChCtrlRel-S-[related-control-children-saliva-(Healthy-siblings-of-PKU-patients)]_UP	NA	Capnocytophaga	Peptostreptococcus	Peptococcus	Leptotrichia	Lachnoanaerobaculum	Porphyromonas	Aggregatibacter
+bsdb:1086/8/2_Phenylketonuria:ChPKU-S-(PKU-children-saliva)-patients_vs_ChCtrlRel-S-[related-control-children-saliva-(Healthy-siblings-of-PKU-patients)]_DOWN	NA	Olsenella	Selenomonas	Atopobium	Actinomyces	Fretibacterium
+bsdb:1086/9/1_Phenylketonuria:Control-Subgingival-plaque-(Ctrl-SP)-patients_vs_Control-Saliva-(Ctrl-S)-patients_UP	NA	Alloprevotella	Atopobium	Gemella	Haemophilus	Neisseria	Oribacterium	Peptostreptococcus	Porphyromonas	Prevotella	Stomatobaculum	Streptococcus	Veillonella	Rothia	Lachnoanaerobaculum
+bsdb:1086/9/2_Phenylketonuria:Control-Subgingival-plaque-(Ctrl-SP)-patients_vs_Control-Saliva-(Ctrl-S)-patients_DOWN	NA	Aggregatibacter	Arachnia	Campylobacter	Capnocytophaga	Cardiobacterium	Corynebacterium	Fusobacterium	Kingella	Leptotrichia	Olsenella	Selenomonas	Tannerella
+bsdb:1086/10/1_Phenylketonuria:Control-Adults-Subgingival-plaque-(Ctrl-Adults-SP)-patients_vs_Control-Adults-Saliva-(Ctrl-Adults-S)-patients_UP	NA	Alloprevotella	Atopobium	Gemella	Haemophilus	Neisseria	Oribacterium	Peptostreptococcus	Porphyromonas	Prevotella	Stomatobaculum	Streptococcus	Veillonella	Rothia
+bsdb:1086/10/2_Phenylketonuria:Control-Adults-Subgingival-plaque-(Ctrl-Adults-SP)-patients_vs_Control-Adults-Saliva-(Ctrl-Adults-S)-patients_DOWN	NA	Aggregatibacter	Arachnia	Campylobacter	Capnocytophaga	Cardiobacterium	Corynebacterium	Fusobacterium	Kingella	Olsenella	Selenomonas	Tannerella
 bsdb:1086/11/1_Phenylketonuria:Control-Children-(CTRL-Ch-SP)_vs_Control-Children-(CTRL-Ch-S)_UP	NA	Prevotella	Oribacterium	Porphyromonas	Neisseria	Alloprevotella	Atopobium	Gemella	Haemophilus	Peptostreptococcus	Stomatobaculum	Streptococcus	Veillonella
 bsdb:1086/11/2_Phenylketonuria:Control-Children-(CTRL-Ch-SP)_vs_Control-Children-(CTRL-Ch-S)_DOWN	NA	Capnocytophaga	Fusobacterium	Corynebacterium	Kingella	Arachnia	Cardiobacterium	Olsenella	Tannerella	Campylobacter	Fretibacterium
 bsdb:1086/12/1_Phenylketonuria:Phenylketonuria-(PKU-SP)_vs_Phenylketonuria-(PKU-S)_UP	NA	Alloprevotella	Atopobium	Gemella	Haemophilus	Lachnoanaerobaculum	Neisseria	Oribacterium	Peptostreptococcus	Porphyromonas	Prevotella	Rothia	Stomatobaculum	Streptococcus	Veillonella
diff --git a/bugsigdb_signatures_mixed_metaphlan.gmt b/bugsigdb_signatures_mixed_metaphlan.gmt
index 192bab645..fe78cce0f 100644
--- a/bugsigdb_signatures_mixed_metaphlan.gmt
+++ b/bugsigdb_signatures_mixed_metaphlan.gmt
@@ -1,4 +1,4 @@
-# BugSigDB 2025-01-14_11:58_UTC, License: Creative Commons Attribution 4.0 International, URL: https://bugsigdb.org
+# BugSigDB 2025-01-14_13:02_UTC, License: Creative Commons Attribution 4.0 International, URL: https://bugsigdb.org
 bsdb:1/1/1_Colorectal-adenoma:conventional-adenoma-cases_vs_controls_UP	NA	k__Bacteria|p__Bacillota|c__Bacilli	k__Bacteria|p__Pseudomonadota|c__Gammaproteobacteria	k__Bacteria|p__Actinomycetota|c__Actinomycetes|o__Actinomycetales|f__Actinomycetaceae|g__Actinomyces	k__Bacteria|p__Actinomycetota|c__Actinomycetes|o__Mycobacteriales|f__Corynebacteriaceae|g__Corynebacterium	k__Bacteria|p__Bacillota|c__Bacilli|o__Lactobacillales|f__Streptococcaceae|g__Streptococcus	k__Bacteria|p__Bacillota|c__Tissierellia|o__Tissierellales|f__Peptoniphilaceae|g__Peptoniphilus	k__Bacteria|p__Bacillota|c__Clostridia|o__Lachnospirales|f__Lachnospiraceae|g__Dorea	k__Bacteria|p__Bacillota|c__Negativicutes|o__Acidaminococcales|f__Acidaminococcaceae|g__Phascolarctobacterium	k__Bacteria|p__Pseudomonadota|c__Betaproteobacteria|o__Burkholderiales|f__Sutterellaceae|g__Sutterella	k__Bacteria|p__Actinomycetota|c__Actinomycetes|o__Actinomycetales	k__Bacteria|p__Actinomycetota|c__Actinomycetes|o__Actinomycetales|f__Actinomycetaceae	k__Bacteria|p__Pseudomonadota|c__Betaproteobacteria|o__Burkholderiales|f__Alcaligenaceae	k__Bacteria|p__Bacillota|c__Bacilli|o__Lactobacillales	k__Bacteria|p__Bacillota|c__Bacilli|o__Lactobacillales|f__Streptococcaceae	k__Bacteria|p__Bacillota|c__Negativicutes|o__Veillonellales|f__Veillonellaceae	k__Bacteria|p__Pseudomonadota|c__Gammaproteobacteria|o__Enterobacterales	k__Bacteria|p__Actinomycetota|c__Actinomycetes|o__Mycobacteriales|f__Corynebacteriaceae	k__Bacteria|p__Bacillota|c__Bacilli|o__Lactobacillales|f__Lactobacillaceae|g__Lacticaseibacillus|s__Lacticaseibacillus zeae	k__Bacteria|p__Bacillota|c__Bacilli|o__Bacillales|f__Bacillaceae|g__Bacillus	k__Bacteria|p__Bacillota|c__Bacilli|o__Bacillales|f__Bacillaceae
 bsdb:1/1/2_Colorectal-adenoma:conventional-adenoma-cases_vs_controls_DOWN	NA	k__Bacteria|p__Bacillota|c__Erysipelotrichia|o__Erysipelotrichales|f__Coprobacillaceae|g__Coprobacillus	k__Bacteria|p__Cyanobacteriota
 bsdb:1/2/1_Hyperplastic-Polyp:hyperplastic-polyp-cases_vs_controls_UP	NA	k__Bacteria|p__Bacillota|c__Clostridia|o__Lachnospirales|f__Lachnospiraceae|g__Anaerostipes	k__Bacteria|p__Bacillota|c__Bacilli|o__Lactobacillales|f__Lactobacillaceae|g__Lacticaseibacillus|s__Lacticaseibacillus zeae
@@ -5094,12 +5094,12 @@ bsdb:1086/6/1_Phenylketonuria:Phenylketonuria-Children-subgingival-plaque-(PKU-C
 bsdb:1086/6/2_Phenylketonuria:Phenylketonuria-Children-subgingival-plaque-(PKU-Ch-SP)-patients_vs_Control-Children-subgingival-plaque-(Ctrl-Ch-SP)-patients_DOWN	NA	k__Bacteria|k__Pseudomonadati|p__Pseudomonadota|c__Gammaproteobacteria|o__Pasteurellales|f__Pasteurellaceae|g__Aggregatibacter	k__Bacteria|k__Pseudomonadati|p__Bacteroidota|c__Flavobacteriia|o__Flavobacteriales|f__Flavobacteriaceae|g__Capnocytophaga	k__Bacteria|k__Bacillati|p__Bacillota|c__Bacilli|o__Bacillales|f__Gemellaceae|g__Gemella	k__Bacteria|k__Fusobacteriati|p__Fusobacteriota|c__Fusobacteriia|o__Fusobacteriales|f__Leptotrichiaceae|g__Leptotrichia
 bsdb:1086/7/1_Phenylketonuria:ChCtrlUnrel-S-(unrelated-control-children-saliva)-patients_vs_ChCtrlRel-S-[related-control-children-saliva-(Healthy-siblings-of-PKU-patients)]_UP	NA	k__Bacteria|k__Pseudomonadati|p__Pseudomonadota|c__Gammaproteobacteria|o__Pasteurellales|f__Pasteurellaceae|g__Haemophilus	k__Bacteria|k__Bacillati|p__Bacillota|c__Clostridia|o__Lachnospirales|f__Lachnospiraceae|g__Lachnoanaerobaculum	k__Bacteria|k__Bacillati|p__Bacillota|c__Clostridia|o__Lachnospirales|f__Lachnospiraceae|g__Oribacterium
 bsdb:1086/7/2_Phenylketonuria:ChCtrlUnrel-S-(unrelated-control-children-saliva)-patients_vs_ChCtrlRel-S-[related-control-children-saliva-(Healthy-siblings-of-PKU-patients)]_DOWN	NA	k__Bacteria|k__Bacillati|p__Actinomycetota|c__Actinomycetes|o__Actinomycetales|f__Actinomycetaceae|g__Actinomyces	k__Bacteria|k__Bacillati|p__Actinomycetota|c__Actinomycetes|o__Propionibacteriales|f__Propionibacteriaceae|g__Arachnia	k__Bacteria|k__Bacillati|p__Actinomycetota|c__Coriobacteriia|o__Coriobacteriales|f__Atopobiaceae|g__Atopobium	k__Bacteria|k__Thermotogati|p__Synergistota|c__Synergistia|o__Synergistales|f__Aminobacteriaceae|g__Fretibacterium	k__Bacteria|k__Pseudomonadati|p__Pseudomonadota|c__Betaproteobacteria|o__Burkholderiales|f__Burkholderiaceae|g__Lautropia	k__Bacteria|k__Bacillati|p__Bacillota|c__Clostridia|o__Peptostreptococcales|f__Peptostreptococcaceae|g__Peptostreptococcus
-bsdb:1086/8/1_Phenylketonuria:Ch-PKU-(PKU-children)_vs_Ch-CTRL-rel-(Healthy-siblings-of-PKU-patients)_UP	NA	k__Bacteria|p__Bacteroidota|c__Flavobacteriia|o__Flavobacteriales|f__Flavobacteriaceae|g__Capnocytophaga	k__Bacteria|p__Bacillota|c__Clostridia|o__Peptostreptococcales|f__Peptostreptococcaceae|g__Peptostreptococcus	k__Bacteria|p__Bacillota|c__Clostridia|o__Eubacteriales|f__Peptococcaceae|g__Peptococcus	k__Bacteria|p__Fusobacteriota|c__Fusobacteriia|o__Fusobacteriales|f__Leptotrichiaceae|g__Leptotrichia	k__Bacteria|p__Bacillota|c__Clostridia|o__Lachnospirales|f__Lachnospiraceae|g__Lachnoanaerobaculum	k__Bacteria|p__Bacteroidota|c__Bacteroidia|o__Bacteroidales|f__Porphyromonadaceae|g__Porphyromonas	k__Bacteria|p__Pseudomonadota|c__Gammaproteobacteria|o__Pasteurellales|f__Pasteurellaceae|g__Aggregatibacter
-bsdb:1086/8/2_Phenylketonuria:Ch-PKU-(PKU-children)_vs_Ch-CTRL-rel-(Healthy-siblings-of-PKU-patients)_DOWN	NA	k__Bacteria|p__Actinomycetota|c__Coriobacteriia|o__Coriobacteriales|f__Atopobiaceae|g__Olsenella	k__Bacteria|p__Bacillota|c__Negativicutes|o__Selenomonadales|f__Selenomonadaceae|g__Selenomonas	k__Bacteria|p__Actinomycetota|c__Coriobacteriia|o__Coriobacteriales|f__Atopobiaceae|g__Atopobium	k__Bacteria|p__Actinomycetota|c__Actinomycetes|o__Actinomycetales|f__Actinomycetaceae|g__Actinomyces	k__Bacteria|p__Synergistota|c__Synergistia|o__Synergistales|f__Aminobacteriaceae|g__Fretibacterium
-bsdb:1086/9/1_Phenylketonuria:Control-(CTRL-SP)_vs_Control-(CTRL-S)_UP	NA	k__Bacteria|p__Bacillota|c__Negativicutes|o__Veillonellales|f__Veillonellaceae|g__Veillonella	k__Bacteria|p__Bacillota|c__Bacilli|o__Lactobacillales|f__Streptococcaceae|g__Streptococcus	k__Bacteria|p__Bacillota|c__Clostridia|o__Lachnospirales|f__Lachnospiraceae|g__Stomatobaculum	k__Bacteria|p__Bacillota|c__Clostridia|o__Peptostreptococcales|f__Peptostreptococcaceae|g__Peptostreptococcus	k__Bacteria|p__Pseudomonadota|c__Gammaproteobacteria|o__Pasteurellales|f__Pasteurellaceae|g__Haemophilus	k__Bacteria|p__Bacillota|c__Bacilli|o__Bacillales|f__Gemellaceae|g__Gemella	k__Bacteria|p__Actinomycetota|c__Coriobacteriia|o__Coriobacteriales|f__Atopobiaceae|g__Atopobium	k__Bacteria|p__Bacteroidota|c__Bacteroidia|o__Bacteroidales|f__Prevotellaceae|g__Alloprevotella	k__Bacteria|p__Pseudomonadota|c__Betaproteobacteria|o__Neisseriales|f__Neisseriaceae|g__Neisseria	k__Bacteria|p__Bacteroidota|c__Bacteroidia|o__Bacteroidales|f__Porphyromonadaceae|g__Porphyromonas	k__Bacteria|p__Bacillota|c__Clostridia|o__Lachnospirales|f__Lachnospiraceae|g__Oribacterium	k__Bacteria|p__Bacteroidota|c__Bacteroidia|o__Bacteroidales|f__Prevotellaceae|g__Prevotella
-bsdb:1086/9/2_Phenylketonuria:Control-(CTRL-SP)_vs_Control-(CTRL-S)_DOWN	NA	k__Bacteria|p__Pseudomonadota|c__Gammaproteobacteria|o__Pasteurellales|f__Pasteurellaceae|g__Aggregatibacter	k__Bacteria|p__Actinomycetota|c__Actinomycetes|o__Propionibacteriales|f__Propionibacteriaceae|g__Arachnia	k__Bacteria|p__Campylobacterota|c__Epsilonproteobacteria|o__Campylobacterales|f__Campylobacteraceae|g__Campylobacter	k__Bacteria|p__Bacteroidota|c__Flavobacteriia|o__Flavobacteriales|f__Flavobacteriaceae|g__Capnocytophaga	k__Bacteria|p__Pseudomonadota|c__Gammaproteobacteria|o__Cardiobacteriales|f__Cardiobacteriaceae|g__Cardiobacterium	k__Bacteria|p__Actinomycetota|c__Actinomycetes|o__Mycobacteriales|f__Corynebacteriaceae|g__Corynebacterium	k__Bacteria|p__Fusobacteriota|c__Fusobacteriia|o__Fusobacteriales|f__Fusobacteriaceae|g__Fusobacterium	k__Bacteria|p__Pseudomonadota|c__Betaproteobacteria|o__Neisseriales|f__Neisseriaceae|g__Kingella	k__Bacteria|p__Fusobacteriota|c__Fusobacteriia|o__Fusobacteriales|f__Leptotrichiaceae|g__Leptotrichia	k__Bacteria|p__Actinomycetota|c__Coriobacteriia|o__Coriobacteriales|f__Atopobiaceae|g__Olsenella	k__Bacteria|p__Bacillota|c__Negativicutes|o__Selenomonadales|f__Selenomonadaceae|g__Selenomonas	k__Bacteria|p__Bacteroidota|c__Bacteroidia|o__Bacteroidales|f__Tannerellaceae|g__Tannerella
-bsdb:1086/10/1_Phenylketonuria:Control-Adults-(CTRL-SP)_vs_Control-Adults-(CTRL-S)_UP	NA	k__Bacteria|p__Bacillota|c__Negativicutes|o__Veillonellales|f__Veillonellaceae|g__Veillonella	k__Bacteria|p__Bacillota|c__Bacilli|o__Lactobacillales|f__Streptococcaceae|g__Streptococcus	k__Bacteria|p__Bacillota|c__Clostridia|o__Lachnospirales|f__Lachnospiraceae|g__Stomatobaculum	k__Bacteria|p__Bacillota|c__Clostridia|o__Peptostreptococcales|f__Peptostreptococcaceae|g__Peptostreptococcus	k__Bacteria|p__Pseudomonadota|c__Gammaproteobacteria|o__Pasteurellales|f__Pasteurellaceae|g__Haemophilus	k__Bacteria|p__Bacillota|c__Bacilli|o__Bacillales|f__Gemellaceae|g__Gemella	k__Bacteria|p__Actinomycetota|c__Coriobacteriia|o__Coriobacteriales|f__Atopobiaceae|g__Atopobium	k__Bacteria|p__Bacteroidota|c__Bacteroidia|o__Bacteroidales|f__Prevotellaceae|g__Alloprevotella	k__Bacteria|p__Pseudomonadota|c__Betaproteobacteria|o__Neisseriales|f__Neisseriaceae|g__Neisseria	k__Bacteria|p__Bacteroidota|c__Bacteroidia|o__Bacteroidales|f__Porphyromonadaceae|g__Porphyromonas	k__Bacteria|p__Bacillota|c__Clostridia|o__Lachnospirales|f__Lachnospiraceae|g__Oribacterium	k__Bacteria|p__Bacteroidota|c__Bacteroidia|o__Bacteroidales|f__Prevotellaceae|g__Prevotella
-bsdb:1086/10/2_Phenylketonuria:Control-Adults-(CTRL-SP)_vs_Control-Adults-(CTRL-S)_DOWN	NA	k__Bacteria|p__Pseudomonadota|c__Gammaproteobacteria|o__Pasteurellales|f__Pasteurellaceae|g__Aggregatibacter	k__Bacteria|p__Actinomycetota|c__Actinomycetes|o__Propionibacteriales|f__Propionibacteriaceae|g__Arachnia	k__Bacteria|p__Campylobacterota|c__Epsilonproteobacteria|o__Campylobacterales|f__Campylobacteraceae|g__Campylobacter	k__Bacteria|p__Bacteroidota|c__Flavobacteriia|o__Flavobacteriales|f__Flavobacteriaceae|g__Capnocytophaga	k__Bacteria|p__Pseudomonadota|c__Gammaproteobacteria|o__Cardiobacteriales|f__Cardiobacteriaceae|g__Cardiobacterium	k__Bacteria|p__Actinomycetota|c__Actinomycetes|o__Mycobacteriales|f__Corynebacteriaceae|g__Corynebacterium	k__Bacteria|p__Fusobacteriota|c__Fusobacteriia|o__Fusobacteriales|f__Fusobacteriaceae|g__Fusobacterium	k__Bacteria|p__Pseudomonadota|c__Betaproteobacteria|o__Neisseriales|f__Neisseriaceae|g__Kingella	k__Bacteria|p__Actinomycetota|c__Coriobacteriia|o__Coriobacteriales|f__Atopobiaceae|g__Olsenella	k__Bacteria|p__Bacillota|c__Negativicutes|o__Selenomonadales|f__Selenomonadaceae|g__Selenomonas	k__Bacteria|p__Bacteroidota|c__Bacteroidia|o__Bacteroidales|f__Tannerellaceae|g__Tannerella
+bsdb:1086/8/1_Phenylketonuria:ChPKU-S-(PKU-children-saliva)-patients_vs_ChCtrlRel-S-[related-control-children-saliva-(Healthy-siblings-of-PKU-patients)]_UP	NA	k__Bacteria|p__Bacteroidota|c__Flavobacteriia|o__Flavobacteriales|f__Flavobacteriaceae|g__Capnocytophaga	k__Bacteria|p__Bacillota|c__Clostridia|o__Peptostreptococcales|f__Peptostreptococcaceae|g__Peptostreptococcus	k__Bacteria|p__Bacillota|c__Clostridia|o__Eubacteriales|f__Peptococcaceae|g__Peptococcus	k__Bacteria|p__Fusobacteriota|c__Fusobacteriia|o__Fusobacteriales|f__Leptotrichiaceae|g__Leptotrichia	k__Bacteria|p__Bacillota|c__Clostridia|o__Lachnospirales|f__Lachnospiraceae|g__Lachnoanaerobaculum	k__Bacteria|p__Bacteroidota|c__Bacteroidia|o__Bacteroidales|f__Porphyromonadaceae|g__Porphyromonas	k__Bacteria|p__Pseudomonadota|c__Gammaproteobacteria|o__Pasteurellales|f__Pasteurellaceae|g__Aggregatibacter
+bsdb:1086/8/2_Phenylketonuria:ChPKU-S-(PKU-children-saliva)-patients_vs_ChCtrlRel-S-[related-control-children-saliva-(Healthy-siblings-of-PKU-patients)]_DOWN	NA	k__Bacteria|p__Actinomycetota|c__Coriobacteriia|o__Coriobacteriales|f__Atopobiaceae|g__Olsenella	k__Bacteria|p__Bacillota|c__Negativicutes|o__Selenomonadales|f__Selenomonadaceae|g__Selenomonas	k__Bacteria|p__Actinomycetota|c__Coriobacteriia|o__Coriobacteriales|f__Atopobiaceae|g__Atopobium	k__Bacteria|p__Actinomycetota|c__Actinomycetes|o__Actinomycetales|f__Actinomycetaceae|g__Actinomyces	k__Bacteria|p__Synergistota|c__Synergistia|o__Synergistales|f__Aminobacteriaceae|g__Fretibacterium
+bsdb:1086/9/1_Phenylketonuria:Control-Subgingival-plaque-(Ctrl-SP)-patients_vs_Control-Saliva-(Ctrl-S)-patients_UP	NA	k__Bacteria|k__Pseudomonadati|p__Bacteroidota|c__Bacteroidia|o__Bacteroidales|f__Prevotellaceae|g__Alloprevotella	k__Bacteria|k__Bacillati|p__Actinomycetota|c__Coriobacteriia|o__Coriobacteriales|f__Atopobiaceae|g__Atopobium	k__Bacteria|k__Bacillati|p__Bacillota|c__Bacilli|o__Bacillales|f__Gemellaceae|g__Gemella	k__Bacteria|k__Pseudomonadati|p__Pseudomonadota|c__Gammaproteobacteria|o__Pasteurellales|f__Pasteurellaceae|g__Haemophilus	k__Bacteria|k__Pseudomonadati|p__Pseudomonadota|c__Betaproteobacteria|o__Neisseriales|f__Neisseriaceae|g__Neisseria	k__Bacteria|k__Bacillati|p__Bacillota|c__Clostridia|o__Lachnospirales|f__Lachnospiraceae|g__Oribacterium	k__Bacteria|k__Bacillati|p__Bacillota|c__Clostridia|o__Peptostreptococcales|f__Peptostreptococcaceae|g__Peptostreptococcus	k__Bacteria|k__Pseudomonadati|p__Bacteroidota|c__Bacteroidia|o__Bacteroidales|f__Porphyromonadaceae|g__Porphyromonas	k__Bacteria|k__Pseudomonadati|p__Bacteroidota|c__Bacteroidia|o__Bacteroidales|f__Prevotellaceae|g__Prevotella	k__Bacteria|k__Bacillati|p__Bacillota|c__Clostridia|o__Lachnospirales|f__Lachnospiraceae|g__Stomatobaculum	k__Bacteria|k__Bacillati|p__Bacillota|c__Bacilli|o__Lactobacillales|f__Streptococcaceae|g__Streptococcus	k__Bacteria|k__Bacillati|p__Bacillota|c__Negativicutes|o__Veillonellales|f__Veillonellaceae|g__Veillonella	k__Eukaryota|k__Viridiplantae|p__Streptophyta|c__Magnoliopsida|o__Fabales|f__Fabaceae|s__Papilionoideae|g__Rothia	k__Bacteria|k__Bacillati|p__Bacillota|c__Clostridia|o__Lachnospirales|f__Lachnospiraceae|g__Lachnoanaerobaculum
+bsdb:1086/9/2_Phenylketonuria:Control-Subgingival-plaque-(Ctrl-SP)-patients_vs_Control-Saliva-(Ctrl-S)-patients_DOWN	NA	k__Bacteria|k__Pseudomonadati|p__Pseudomonadota|c__Gammaproteobacteria|o__Pasteurellales|f__Pasteurellaceae|g__Aggregatibacter	k__Bacteria|k__Bacillati|p__Actinomycetota|c__Actinomycetes|o__Propionibacteriales|f__Propionibacteriaceae|g__Arachnia	k__Bacteria|k__Pseudomonadati|p__Campylobacterota|c__Epsilonproteobacteria|o__Campylobacterales|f__Campylobacteraceae|g__Campylobacter	k__Bacteria|k__Pseudomonadati|p__Bacteroidota|c__Flavobacteriia|o__Flavobacteriales|f__Flavobacteriaceae|g__Capnocytophaga	k__Bacteria|k__Pseudomonadati|p__Pseudomonadota|c__Gammaproteobacteria|o__Cardiobacteriales|f__Cardiobacteriaceae|g__Cardiobacterium	k__Bacteria|k__Bacillati|p__Actinomycetota|c__Actinomycetes|o__Mycobacteriales|f__Corynebacteriaceae|g__Corynebacterium	k__Bacteria|k__Fusobacteriati|p__Fusobacteriota|c__Fusobacteriia|o__Fusobacteriales|f__Fusobacteriaceae|g__Fusobacterium	k__Bacteria|k__Pseudomonadati|p__Pseudomonadota|c__Betaproteobacteria|o__Neisseriales|f__Neisseriaceae|g__Kingella	k__Bacteria|k__Fusobacteriati|p__Fusobacteriota|c__Fusobacteriia|o__Fusobacteriales|f__Leptotrichiaceae|g__Leptotrichia	k__Bacteria|k__Bacillati|p__Actinomycetota|c__Coriobacteriia|o__Coriobacteriales|f__Atopobiaceae|g__Olsenella	k__Bacteria|k__Bacillati|p__Bacillota|c__Negativicutes|o__Selenomonadales|f__Selenomonadaceae|g__Selenomonas	k__Bacteria|k__Pseudomonadati|p__Bacteroidota|c__Bacteroidia|o__Bacteroidales|f__Tannerellaceae|g__Tannerella
+bsdb:1086/10/1_Phenylketonuria:Control-Adults-Subgingival-plaque-(Ctrl-Adults-SP)-patients_vs_Control-Adults-Saliva-(Ctrl-Adults-S)-patients_UP	NA	k__Bacteria|k__Pseudomonadati|p__Bacteroidota|c__Bacteroidia|o__Bacteroidales|f__Prevotellaceae|g__Alloprevotella	k__Bacteria|k__Bacillati|p__Actinomycetota|c__Coriobacteriia|o__Coriobacteriales|f__Atopobiaceae|g__Atopobium	k__Bacteria|k__Bacillati|p__Bacillota|c__Bacilli|o__Bacillales|f__Gemellaceae|g__Gemella	k__Bacteria|k__Pseudomonadati|p__Pseudomonadota|c__Gammaproteobacteria|o__Pasteurellales|f__Pasteurellaceae|g__Haemophilus	k__Bacteria|k__Pseudomonadati|p__Pseudomonadota|c__Betaproteobacteria|o__Neisseriales|f__Neisseriaceae|g__Neisseria	k__Bacteria|k__Bacillati|p__Bacillota|c__Clostridia|o__Lachnospirales|f__Lachnospiraceae|g__Oribacterium	k__Bacteria|k__Bacillati|p__Bacillota|c__Clostridia|o__Peptostreptococcales|f__Peptostreptococcaceae|g__Peptostreptococcus	k__Bacteria|k__Pseudomonadati|p__Bacteroidota|c__Bacteroidia|o__Bacteroidales|f__Porphyromonadaceae|g__Porphyromonas	k__Bacteria|k__Pseudomonadati|p__Bacteroidota|c__Bacteroidia|o__Bacteroidales|f__Prevotellaceae|g__Prevotella	k__Bacteria|k__Bacillati|p__Bacillota|c__Clostridia|o__Lachnospirales|f__Lachnospiraceae|g__Stomatobaculum	k__Bacteria|k__Bacillati|p__Bacillota|c__Bacilli|o__Lactobacillales|f__Streptococcaceae|g__Streptococcus	k__Bacteria|k__Bacillati|p__Bacillota|c__Negativicutes|o__Veillonellales|f__Veillonellaceae|g__Veillonella	k__Eukaryota|k__Viridiplantae|p__Streptophyta|c__Magnoliopsida|o__Fabales|f__Fabaceae|s__Papilionoideae|g__Rothia
+bsdb:1086/10/2_Phenylketonuria:Control-Adults-Subgingival-plaque-(Ctrl-Adults-SP)-patients_vs_Control-Adults-Saliva-(Ctrl-Adults-S)-patients_DOWN	NA	k__Bacteria|k__Pseudomonadati|p__Pseudomonadota|c__Gammaproteobacteria|o__Pasteurellales|f__Pasteurellaceae|g__Aggregatibacter	k__Bacteria|k__Bacillati|p__Actinomycetota|c__Actinomycetes|o__Propionibacteriales|f__Propionibacteriaceae|g__Arachnia	k__Bacteria|k__Pseudomonadati|p__Campylobacterota|c__Epsilonproteobacteria|o__Campylobacterales|f__Campylobacteraceae|g__Campylobacter	k__Bacteria|k__Pseudomonadati|p__Bacteroidota|c__Flavobacteriia|o__Flavobacteriales|f__Flavobacteriaceae|g__Capnocytophaga	k__Bacteria|k__Pseudomonadati|p__Pseudomonadota|c__Gammaproteobacteria|o__Cardiobacteriales|f__Cardiobacteriaceae|g__Cardiobacterium	k__Bacteria|k__Bacillati|p__Actinomycetota|c__Actinomycetes|o__Mycobacteriales|f__Corynebacteriaceae|g__Corynebacterium	k__Bacteria|k__Fusobacteriati|p__Fusobacteriota|c__Fusobacteriia|o__Fusobacteriales|f__Fusobacteriaceae|g__Fusobacterium	k__Bacteria|k__Pseudomonadati|p__Pseudomonadota|c__Betaproteobacteria|o__Neisseriales|f__Neisseriaceae|g__Kingella	k__Bacteria|k__Bacillati|p__Actinomycetota|c__Coriobacteriia|o__Coriobacteriales|f__Atopobiaceae|g__Olsenella	k__Bacteria|k__Bacillati|p__Bacillota|c__Negativicutes|o__Selenomonadales|f__Selenomonadaceae|g__Selenomonas	k__Bacteria|k__Pseudomonadati|p__Bacteroidota|c__Bacteroidia|o__Bacteroidales|f__Tannerellaceae|g__Tannerella
 bsdb:1086/11/1_Phenylketonuria:Control-Children-(CTRL-Ch-SP)_vs_Control-Children-(CTRL-Ch-S)_UP	NA	k__Bacteria|p__Bacteroidota|c__Bacteroidia|o__Bacteroidales|f__Prevotellaceae|g__Prevotella	k__Bacteria|p__Bacillota|c__Clostridia|o__Lachnospirales|f__Lachnospiraceae|g__Oribacterium	k__Bacteria|p__Bacteroidota|c__Bacteroidia|o__Bacteroidales|f__Porphyromonadaceae|g__Porphyromonas	k__Bacteria|p__Pseudomonadota|c__Betaproteobacteria|o__Neisseriales|f__Neisseriaceae|g__Neisseria	k__Bacteria|p__Bacteroidota|c__Bacteroidia|o__Bacteroidales|f__Prevotellaceae|g__Alloprevotella	k__Bacteria|p__Actinomycetota|c__Coriobacteriia|o__Coriobacteriales|f__Atopobiaceae|g__Atopobium	k__Bacteria|p__Bacillota|c__Bacilli|o__Bacillales|f__Gemellaceae|g__Gemella	k__Bacteria|p__Pseudomonadota|c__Gammaproteobacteria|o__Pasteurellales|f__Pasteurellaceae|g__Haemophilus	k__Bacteria|p__Bacillota|c__Clostridia|o__Peptostreptococcales|f__Peptostreptococcaceae|g__Peptostreptococcus	k__Bacteria|p__Bacillota|c__Clostridia|o__Lachnospirales|f__Lachnospiraceae|g__Stomatobaculum	k__Bacteria|p__Bacillota|c__Bacilli|o__Lactobacillales|f__Streptococcaceae|g__Streptococcus	k__Bacteria|p__Bacillota|c__Negativicutes|o__Veillonellales|f__Veillonellaceae|g__Veillonella
 bsdb:1086/11/2_Phenylketonuria:Control-Children-(CTRL-Ch-SP)_vs_Control-Children-(CTRL-Ch-S)_DOWN	NA	k__Bacteria|p__Bacteroidota|c__Flavobacteriia|o__Flavobacteriales|f__Flavobacteriaceae|g__Capnocytophaga	k__Bacteria|p__Fusobacteriota|c__Fusobacteriia|o__Fusobacteriales|f__Fusobacteriaceae|g__Fusobacterium	k__Bacteria|p__Actinomycetota|c__Actinomycetes|o__Mycobacteriales|f__Corynebacteriaceae|g__Corynebacterium	k__Bacteria|p__Pseudomonadota|c__Betaproteobacteria|o__Neisseriales|f__Neisseriaceae|g__Kingella	k__Bacteria|p__Actinomycetota|c__Actinomycetes|o__Propionibacteriales|f__Propionibacteriaceae|g__Arachnia	k__Bacteria|p__Pseudomonadota|c__Gammaproteobacteria|o__Cardiobacteriales|f__Cardiobacteriaceae|g__Cardiobacterium	k__Bacteria|p__Actinomycetota|c__Coriobacteriia|o__Coriobacteriales|f__Atopobiaceae|g__Olsenella	k__Bacteria|p__Bacteroidota|c__Bacteroidia|o__Bacteroidales|f__Tannerellaceae|g__Tannerella	k__Bacteria|p__Campylobacterota|c__Epsilonproteobacteria|o__Campylobacterales|f__Campylobacteraceae|g__Campylobacter	k__Bacteria|p__Synergistota|c__Synergistia|o__Synergistales|f__Aminobacteriaceae|g__Fretibacterium
 bsdb:1086/12/1_Phenylketonuria:Phenylketonuria-(PKU-SP)_vs_Phenylketonuria-(PKU-S)_UP	NA	k__Bacteria|p__Bacteroidota|c__Bacteroidia|o__Bacteroidales|f__Prevotellaceae|g__Alloprevotella	k__Bacteria|p__Actinomycetota|c__Coriobacteriia|o__Coriobacteriales|f__Atopobiaceae|g__Atopobium	k__Bacteria|p__Bacillota|c__Bacilli|o__Bacillales|f__Gemellaceae|g__Gemella	k__Bacteria|p__Pseudomonadota|c__Gammaproteobacteria|o__Pasteurellales|f__Pasteurellaceae|g__Haemophilus	k__Bacteria|p__Bacillota|c__Clostridia|o__Lachnospirales|f__Lachnospiraceae|g__Lachnoanaerobaculum	k__Bacteria|p__Pseudomonadota|c__Betaproteobacteria|o__Neisseriales|f__Neisseriaceae|g__Neisseria	k__Bacteria|p__Bacillota|c__Clostridia|o__Lachnospirales|f__Lachnospiraceae|g__Oribacterium	k__Bacteria|p__Bacillota|c__Clostridia|o__Peptostreptococcales|f__Peptostreptococcaceae|g__Peptostreptococcus	k__Bacteria|p__Bacteroidota|c__Bacteroidia|o__Bacteroidales|f__Porphyromonadaceae|g__Porphyromonas	k__Bacteria|p__Bacteroidota|c__Bacteroidia|o__Bacteroidales|f__Prevotellaceae|g__Prevotella	k__Eukaryota|k__Viridiplantae|p__Streptophyta|c__Magnoliopsida|o__Fabales|f__Fabaceae|s__Papilionoideae|g__Rothia	k__Bacteria|p__Bacillota|c__Clostridia|o__Lachnospirales|f__Lachnospiraceae|g__Stomatobaculum	k__Bacteria|p__Bacillota|c__Bacilli|o__Lactobacillales|f__Streptococcaceae|g__Streptococcus	k__Bacteria|p__Bacillota|c__Negativicutes|o__Veillonellales|f__Veillonellaceae|g__Veillonella
@@ -5553,6 +5553,8 @@ bsdb:1163/1/2_HIV-infection:HIV-positive-(naive)_vs_Non-infected-volunteers-(Con
 bsdb:1163/2/1_HIV-infection:HIV-positive-(cART)_vs_non-infected-volunteers-(Control)_UP	NA	k__Bacteria|k__Pseudomonadati|p__Pseudomonadota
 bsdb:1163/2/2_HIV-infection:HIV-positive-(cART)_vs_non-infected-volunteers-(Control)_DOWN	NA	k__Bacteria|k__Bacillati|p__Bacillota
 bsdb:1163/3/1_HIV-infection:NRTIs-+-PIs_vs_non-infected-volunteers-(Control)_UP	NA	k__Bacteria|k__Bacillati|p__Actinomycetota
+bsdb:1163/3/2_HIV-infection:NRTIs-+-PIs_vs_non-infected-volunteers-(Control)_DOWN	NA	k__Bacteria|k__Bacillati|p__Bacillota
+bsdb:1163/4/1_HIV-infection:NRTIs-+-NNRTIs_vs_non-infected-volunteers-(C0ntrol)_UP	NA	k__Bacteria|k__Pseudomonadati|p__Pseudomonadota
 bsdb:1163/6/1_HIV-infection:NRTIs+PIs_vs_non-infected-volunteers-(Control)_UP	NA	k__Bacteria|k__Bacillati|p__Bacillota|c__Clostridia|o__Eubacteriales|s__Clostridiales bacterium	k__Bacteria|k__Bacillati|p__Bacillota|c__Clostridia|o__Lachnospirales|f__Lachnospiraceae	k__Bacteria|k__Bacillati|p__Actinomycetota|c__Coriobacteriia|o__Eggerthellales|f__Eggerthellaceae|g__Eggerthella	k__Bacteria|k__Bacillati|p__Bacillota|c__Clostridia|o__Eubacteriales|f__Oscillospiraceae|g__Flavonifractor|s__Flavonifractor plautii
 bsdb:1163/6/2_HIV-infection:NRTIs+PIs_vs_non-infected-volunteers-(Control)_DOWN	NA	k__Bacteria|k__Bacillati|p__Actinomycetota|c__Actinomycetes|o__Actinomycetales	k__Bacteria|k__Pseudomonadati|p__Pseudomonadota|c__Gammaproteobacteria|o__Pseudomonadales	k__Bacteria|k__Pseudomonadati|p__Pseudomonadota|c__Alphaproteobacteria|o__Sphingomonadales	k__Bacteria|k__Pseudomonadati|p__Bacteroidota|c__Bacteroidia|o__Bacteroidales|f__Prevotellaceae	k__Bacteria|k__Pseudomonadati|p__Bacteroidota|c__Bacteroidia|o__Bacteroidales|f__Prevotellaceae|g__Prevotella	k__Bacteria|k__Bacillati|p__Bacillota|c__Erysipelotrichia|o__Erysipelotrichales|f__Erysipelotrichaceae|g__Solobacterium
 bsdb:1163/7/1_HIV-infection:NRTIs-+-NNRTIs_vs_non-infected-volunteers-(Control)_UP	NA	k__Bacteria|k__Pseudomonadati|p__Bacteroidota|c__Bacteroidia|o__Bacteroidales|f__Rikenellaceae|g__Alistipes|s__Alistipes senegalensis	k__Bacteria|k__Pseudomonadati|p__Bacteroidota|c__Bacteroidia|o__Bacteroidales|f__Bacteroidaceae|s__Bacteroidaceae bacterium	k__Bacteria|k__Pseudomonadati|p__Bacteroidota|c__Bacteroidia|o__Bacteroidales|s__Bacteroidales bacterium	k__Bacteria|k__Bacillati|p__Actinomycetota|c__Coriobacteriia|o__Coriobacteriales|f__Coriobacteriaceae	k__Bacteria|k__Bacillati|p__Actinomycetota|c__Coriobacteriia|o__Coriobacteriales	k__Bacteria|k__Bacillati|p__Bacillota|c__Clostridia|o__Lachnospirales|f__Lachnospiraceae	k__Bacteria|k__Pseudomonadati|p__Pseudomonadota|c__Gammaproteobacteria|o__Pseudomonadales|f__Pseudomonadaceae|g__Pseudomonas	k__Bacteria|k__Bacillati|p__Bacillota|c__Bacilli|o__Lactobacillales|f__Streptococcaceae|g__Streptococcus
diff --git a/bugsigdb_signatures_mixed_ncbi.gmt b/bugsigdb_signatures_mixed_ncbi.gmt
index 3dd6d8c02..a1f00215a 100644
--- a/bugsigdb_signatures_mixed_ncbi.gmt
+++ b/bugsigdb_signatures_mixed_ncbi.gmt
@@ -1,4 +1,4 @@
-# BugSigDB 2025-01-14_11:58_UTC, License: Creative Commons Attribution 4.0 International, URL: https://bugsigdb.org
+# BugSigDB 2025-01-14_13:02_UTC, License: Creative Commons Attribution 4.0 International, URL: https://bugsigdb.org
 bsdb:1/1/1_Colorectal-adenoma:conventional-adenoma-cases_vs_controls_UP	NA	91061	1236	1654	1716	1301	162289	189330	33024	40544	2037	2049	506	186826	1300	31977	91347	1653	57037	1386	186817
 bsdb:1/1/2_Colorectal-adenoma:conventional-adenoma-cases_vs_controls_DOWN	NA	100883	1117
 bsdb:1/2/1_Hyperplastic-Polyp:hyperplastic-polyp-cases_vs_controls_UP	NA	207244	57037
@@ -5094,12 +5094,12 @@ bsdb:1086/6/1_Phenylketonuria:Phenylketonuria-Children-subgingival-plaque-(PKU-C
 bsdb:1086/6/2_Phenylketonuria:Phenylketonuria-Children-subgingival-plaque-(PKU-Ch-SP)-patients_vs_Control-Children-subgingival-plaque-(Ctrl-Ch-SP)-patients_DOWN	NA	416916	1016	1378	32067
 bsdb:1086/7/1_Phenylketonuria:ChCtrlUnrel-S-(unrelated-control-children-saliva)-patients_vs_ChCtrlRel-S-[related-control-children-saliva-(Healthy-siblings-of-PKU-patients)]_UP	NA	724	1164882	265975
 bsdb:1086/7/2_Phenylketonuria:ChCtrlUnrel-S-(unrelated-control-children-saliva)-patients_vs_ChCtrlRel-S-[related-control-children-saliva-(Healthy-siblings-of-PKU-patients)]_DOWN	NA	1654	2801844	1380	1434006	47670	1257
-bsdb:1086/8/1_Phenylketonuria:Ch-PKU-(PKU-children)_vs_Ch-CTRL-rel-(Healthy-siblings-of-PKU-patients)_UP	NA	1016	1257	2740	32067	1164882	836	416916
-bsdb:1086/8/2_Phenylketonuria:Ch-PKU-(PKU-children)_vs_Ch-CTRL-rel-(Healthy-siblings-of-PKU-patients)_DOWN	NA	133925	970	1380	1654	1434006
-bsdb:1086/9/1_Phenylketonuria:Control-(CTRL-SP)_vs_Control-(CTRL-S)_UP	NA	29465	1301	1213720	1257	724	1378	1380	1283313	482	836	265975	838
-bsdb:1086/9/2_Phenylketonuria:Control-(CTRL-SP)_vs_Control-(CTRL-S)_DOWN	NA	416916	2801844	194	1016	2717	1716	848	32257	32067	133925	970	195950
-bsdb:1086/10/1_Phenylketonuria:Control-Adults-(CTRL-SP)_vs_Control-Adults-(CTRL-S)_UP	NA	29465	1301	1213720	1257	724	1378	1380	1283313	482	836	265975	838
-bsdb:1086/10/2_Phenylketonuria:Control-Adults-(CTRL-SP)_vs_Control-Adults-(CTRL-S)_DOWN	NA	416916	2801844	194	1016	2717	1716	848	32257	133925	970	195950
+bsdb:1086/8/1_Phenylketonuria:ChPKU-S-(PKU-children-saliva)-patients_vs_ChCtrlRel-S-[related-control-children-saliva-(Healthy-siblings-of-PKU-patients)]_UP	NA	1016	1257	2740	32067	1164882	836	416916
+bsdb:1086/8/2_Phenylketonuria:ChPKU-S-(PKU-children-saliva)-patients_vs_ChCtrlRel-S-[related-control-children-saliva-(Healthy-siblings-of-PKU-patients)]_DOWN	NA	133925	970	1380	1654	1434006
+bsdb:1086/9/1_Phenylketonuria:Control-Subgingival-plaque-(Ctrl-SP)-patients_vs_Control-Saliva-(Ctrl-S)-patients_UP	NA	1283313	1380	1378	724	482	265975	1257	836	838	1213720	1301	29465	508215	1164882
+bsdb:1086/9/2_Phenylketonuria:Control-Subgingival-plaque-(Ctrl-SP)-patients_vs_Control-Saliva-(Ctrl-S)-patients_DOWN	NA	416916	2801844	194	1016	2717	1716	848	32257	32067	133925	970	195950
+bsdb:1086/10/1_Phenylketonuria:Control-Adults-Subgingival-plaque-(Ctrl-Adults-SP)-patients_vs_Control-Adults-Saliva-(Ctrl-Adults-S)-patients_UP	NA	1283313	1380	1378	724	482	265975	1257	836	838	1213720	1301	29465	508215
+bsdb:1086/10/2_Phenylketonuria:Control-Adults-Subgingival-plaque-(Ctrl-Adults-SP)-patients_vs_Control-Adults-Saliva-(Ctrl-Adults-S)-patients_DOWN	NA	416916	2801844	194	1016	2717	1716	848	32257	133925	970	195950
 bsdb:1086/11/1_Phenylketonuria:Control-Children-(CTRL-Ch-SP)_vs_Control-Children-(CTRL-Ch-S)_UP	NA	838	265975	836	482	1283313	1380	1378	724	1257	1213720	1301	29465
 bsdb:1086/11/2_Phenylketonuria:Control-Children-(CTRL-Ch-SP)_vs_Control-Children-(CTRL-Ch-S)_DOWN	NA	1016	848	1716	32257	2801844	2717	133925	195950	194	1434006
 bsdb:1086/12/1_Phenylketonuria:Phenylketonuria-(PKU-SP)_vs_Phenylketonuria-(PKU-S)_UP	NA	1283313	1380	1378	724	1164882	482	265975	1257	836	838	508215	1213720	1301	29465
@@ -5553,6 +5553,8 @@ bsdb:1163/1/2_HIV-infection:HIV-positive-(naive)_vs_Non-infected-volunteers-(Con
 bsdb:1163/2/1_HIV-infection:HIV-positive-(cART)_vs_non-infected-volunteers-(Control)_UP	NA	1224
 bsdb:1163/2/2_HIV-infection:HIV-positive-(cART)_vs_non-infected-volunteers-(Control)_DOWN	NA	1239
 bsdb:1163/3/1_HIV-infection:NRTIs-+-PIs_vs_non-infected-volunteers-(Control)_UP	NA	201174
+bsdb:1163/3/2_HIV-infection:NRTIs-+-PIs_vs_non-infected-volunteers-(Control)_DOWN	NA	1239
+bsdb:1163/4/1_HIV-infection:NRTIs-+-NNRTIs_vs_non-infected-volunteers-(C0ntrol)_UP	NA	1224
 bsdb:1163/6/1_HIV-infection:NRTIs+PIs_vs_non-infected-volunteers-(Control)_UP	NA	1898207	186803	84111	292800
 bsdb:1163/6/2_HIV-infection:NRTIs+PIs_vs_non-infected-volunteers-(Control)_DOWN	NA	2037	72274	204457	171552	838	123375
 bsdb:1163/7/1_HIV-infection:NRTIs-+-NNRTIs_vs_non-infected-volunteers-(Control)_UP	NA	1288121	2212467	2030927	84107	84999	186803	286	1301
diff --git a/bugsigdb_signatures_mixed_taxname.gmt b/bugsigdb_signatures_mixed_taxname.gmt
index 28df13bb6..d4f127a81 100644
--- a/bugsigdb_signatures_mixed_taxname.gmt
+++ b/bugsigdb_signatures_mixed_taxname.gmt
@@ -1,4 +1,4 @@
-# BugSigDB 2025-01-14_11:58_UTC, License: Creative Commons Attribution 4.0 International, URL: https://bugsigdb.org
+# BugSigDB 2025-01-14_13:02_UTC, License: Creative Commons Attribution 4.0 International, URL: https://bugsigdb.org
 bsdb:1/1/1_Colorectal-adenoma:conventional-adenoma-cases_vs_controls_UP	NA	Bacilli	Gammaproteobacteria	Actinomyces	Corynebacterium	Streptococcus	Peptoniphilus	Dorea	Phascolarctobacterium	Sutterella	Actinomycetales	Actinomycetaceae	Alcaligenaceae	Lactobacillales	Streptococcaceae	Veillonellaceae	Enterobacterales	Corynebacteriaceae	Lacticaseibacillus zeae	Bacillus	Bacillaceae
 bsdb:1/1/2_Colorectal-adenoma:conventional-adenoma-cases_vs_controls_DOWN	NA	Coprobacillus	Cyanobacteriota
 bsdb:1/2/1_Hyperplastic-Polyp:hyperplastic-polyp-cases_vs_controls_UP	NA	Anaerostipes	Lacticaseibacillus zeae
@@ -5094,12 +5094,12 @@ bsdb:1086/6/1_Phenylketonuria:Phenylketonuria-Children-subgingival-plaque-(PKU-C
 bsdb:1086/6/2_Phenylketonuria:Phenylketonuria-Children-subgingival-plaque-(PKU-Ch-SP)-patients_vs_Control-Children-subgingival-plaque-(Ctrl-Ch-SP)-patients_DOWN	NA	Aggregatibacter	Capnocytophaga	Gemella	Leptotrichia
 bsdb:1086/7/1_Phenylketonuria:ChCtrlUnrel-S-(unrelated-control-children-saliva)-patients_vs_ChCtrlRel-S-[related-control-children-saliva-(Healthy-siblings-of-PKU-patients)]_UP	NA	Haemophilus	Lachnoanaerobaculum	Oribacterium
 bsdb:1086/7/2_Phenylketonuria:ChCtrlUnrel-S-(unrelated-control-children-saliva)-patients_vs_ChCtrlRel-S-[related-control-children-saliva-(Healthy-siblings-of-PKU-patients)]_DOWN	NA	Actinomyces	Arachnia	Atopobium	Fretibacterium	Lautropia	Peptostreptococcus
-bsdb:1086/8/1_Phenylketonuria:Ch-PKU-(PKU-children)_vs_Ch-CTRL-rel-(Healthy-siblings-of-PKU-patients)_UP	NA	Capnocytophaga	Peptostreptococcus	Peptococcus	Leptotrichia	Lachnoanaerobaculum	Porphyromonas	Aggregatibacter
-bsdb:1086/8/2_Phenylketonuria:Ch-PKU-(PKU-children)_vs_Ch-CTRL-rel-(Healthy-siblings-of-PKU-patients)_DOWN	NA	Olsenella	Selenomonas	Atopobium	Actinomyces	Fretibacterium
-bsdb:1086/9/1_Phenylketonuria:Control-(CTRL-SP)_vs_Control-(CTRL-S)_UP	NA	Veillonella	Streptococcus	Stomatobaculum	Peptostreptococcus	Haemophilus	Gemella	Atopobium	Alloprevotella	Neisseria	Porphyromonas	Oribacterium	Prevotella
-bsdb:1086/9/2_Phenylketonuria:Control-(CTRL-SP)_vs_Control-(CTRL-S)_DOWN	NA	Aggregatibacter	Arachnia	Campylobacter	Capnocytophaga	Cardiobacterium	Corynebacterium	Fusobacterium	Kingella	Leptotrichia	Olsenella	Selenomonas	Tannerella
-bsdb:1086/10/1_Phenylketonuria:Control-Adults-(CTRL-SP)_vs_Control-Adults-(CTRL-S)_UP	NA	Veillonella	Streptococcus	Stomatobaculum	Peptostreptococcus	Haemophilus	Gemella	Atopobium	Alloprevotella	Neisseria	Porphyromonas	Oribacterium	Prevotella
-bsdb:1086/10/2_Phenylketonuria:Control-Adults-(CTRL-SP)_vs_Control-Adults-(CTRL-S)_DOWN	NA	Aggregatibacter	Arachnia	Campylobacter	Capnocytophaga	Cardiobacterium	Corynebacterium	Fusobacterium	Kingella	Olsenella	Selenomonas	Tannerella
+bsdb:1086/8/1_Phenylketonuria:ChPKU-S-(PKU-children-saliva)-patients_vs_ChCtrlRel-S-[related-control-children-saliva-(Healthy-siblings-of-PKU-patients)]_UP	NA	Capnocytophaga	Peptostreptococcus	Peptococcus	Leptotrichia	Lachnoanaerobaculum	Porphyromonas	Aggregatibacter
+bsdb:1086/8/2_Phenylketonuria:ChPKU-S-(PKU-children-saliva)-patients_vs_ChCtrlRel-S-[related-control-children-saliva-(Healthy-siblings-of-PKU-patients)]_DOWN	NA	Olsenella	Selenomonas	Atopobium	Actinomyces	Fretibacterium
+bsdb:1086/9/1_Phenylketonuria:Control-Subgingival-plaque-(Ctrl-SP)-patients_vs_Control-Saliva-(Ctrl-S)-patients_UP	NA	Alloprevotella	Atopobium	Gemella	Haemophilus	Neisseria	Oribacterium	Peptostreptococcus	Porphyromonas	Prevotella	Stomatobaculum	Streptococcus	Veillonella	Rothia	Lachnoanaerobaculum
+bsdb:1086/9/2_Phenylketonuria:Control-Subgingival-plaque-(Ctrl-SP)-patients_vs_Control-Saliva-(Ctrl-S)-patients_DOWN	NA	Aggregatibacter	Arachnia	Campylobacter	Capnocytophaga	Cardiobacterium	Corynebacterium	Fusobacterium	Kingella	Leptotrichia	Olsenella	Selenomonas	Tannerella
+bsdb:1086/10/1_Phenylketonuria:Control-Adults-Subgingival-plaque-(Ctrl-Adults-SP)-patients_vs_Control-Adults-Saliva-(Ctrl-Adults-S)-patients_UP	NA	Alloprevotella	Atopobium	Gemella	Haemophilus	Neisseria	Oribacterium	Peptostreptococcus	Porphyromonas	Prevotella	Stomatobaculum	Streptococcus	Veillonella	Rothia
+bsdb:1086/10/2_Phenylketonuria:Control-Adults-Subgingival-plaque-(Ctrl-Adults-SP)-patients_vs_Control-Adults-Saliva-(Ctrl-Adults-S)-patients_DOWN	NA	Aggregatibacter	Arachnia	Campylobacter	Capnocytophaga	Cardiobacterium	Corynebacterium	Fusobacterium	Kingella	Olsenella	Selenomonas	Tannerella
 bsdb:1086/11/1_Phenylketonuria:Control-Children-(CTRL-Ch-SP)_vs_Control-Children-(CTRL-Ch-S)_UP	NA	Prevotella	Oribacterium	Porphyromonas	Neisseria	Alloprevotella	Atopobium	Gemella	Haemophilus	Peptostreptococcus	Stomatobaculum	Streptococcus	Veillonella
 bsdb:1086/11/2_Phenylketonuria:Control-Children-(CTRL-Ch-SP)_vs_Control-Children-(CTRL-Ch-S)_DOWN	NA	Capnocytophaga	Fusobacterium	Corynebacterium	Kingella	Arachnia	Cardiobacterium	Olsenella	Tannerella	Campylobacter	Fretibacterium
 bsdb:1086/12/1_Phenylketonuria:Phenylketonuria-(PKU-SP)_vs_Phenylketonuria-(PKU-S)_UP	NA	Alloprevotella	Atopobium	Gemella	Haemophilus	Lachnoanaerobaculum	Neisseria	Oribacterium	Peptostreptococcus	Porphyromonas	Prevotella	Rothia	Stomatobaculum	Streptococcus	Veillonella
@@ -5553,6 +5553,8 @@ bsdb:1163/1/2_HIV-infection:HIV-positive-(naive)_vs_Non-infected-volunteers-(Con
 bsdb:1163/2/1_HIV-infection:HIV-positive-(cART)_vs_non-infected-volunteers-(Control)_UP	NA	Pseudomonadota
 bsdb:1163/2/2_HIV-infection:HIV-positive-(cART)_vs_non-infected-volunteers-(Control)_DOWN	NA	Bacillota
 bsdb:1163/3/1_HIV-infection:NRTIs-+-PIs_vs_non-infected-volunteers-(Control)_UP	NA	Actinomycetota
+bsdb:1163/3/2_HIV-infection:NRTIs-+-PIs_vs_non-infected-volunteers-(Control)_DOWN	NA	Bacillota
+bsdb:1163/4/1_HIV-infection:NRTIs-+-NNRTIs_vs_non-infected-volunteers-(C0ntrol)_UP	NA	Pseudomonadota
 bsdb:1163/6/1_HIV-infection:NRTIs+PIs_vs_non-infected-volunteers-(Control)_UP	NA	Clostridiales bacterium	Lachnospiraceae	Eggerthella	Flavonifractor plautii
 bsdb:1163/6/2_HIV-infection:NRTIs+PIs_vs_non-infected-volunteers-(Control)_DOWN	NA	Actinomycetales	Pseudomonadales	Sphingomonadales	Prevotellaceae	Prevotella	Solobacterium
 bsdb:1163/7/1_HIV-infection:NRTIs-+-NNRTIs_vs_non-infected-volunteers-(Control)_UP	NA	Alistipes senegalensis	Bacteroidaceae bacterium	Bacteroidales bacterium	Coriobacteriaceae	Coriobacteriales	Lachnospiraceae	Pseudomonas	Streptococcus
diff --git a/file_size.csv b/file_size.csv
index 6dc9860d7..118364fdc 100644
--- a/file_size.csv
+++ b/file_size.csv
@@ -2533,3 +2533,4 @@
 "2025-01-14_09:58_UTC" "4898" "5742" "4898" "5742" "4898" "5742" "6664" "6664" "6664" "3012" "3012" "3012" "3012" "3012" "3012" "4497" "7770" "7375" "1368"
 "2025-01-14_10:58_UTC" "4898" "5742" "4898" "5742" "4898" "5742" "6664" "6664" "6664" "3012" "3012" "3012" "3012" "3012" "3012" "4497" "7770" "7375" "1368"
 "2025-01-14_11:58_UTC" "4898" "5742" "4898" "5742" "4898" "5742" "6667" "6667" "6667" "3012" "3012" "3012" "3012" "3012" "3012" "4497" "7770" "7375" "1368"
+"2025-01-14_13:02_UTC" "4898" "5742" "4898" "5742" "4898" "5742" "6669" "6669" "6669" "3012" "3012" "3012" "3012" "3012" "3012" "4497" "7770" "7375" "1368"
diff --git a/full_dump.csv b/full_dump.csv
index 856c90e83..28e0a2741 100644
--- a/full_dump.csv
+++ b/full_dump.csv
@@ -1,4 +1,4 @@
-# BugSigDB 2025-01-14_11:58_UTC, License: Creative Commons Attribution 4.0 International, URL: https://bugsigdb.org
+# BugSigDB 2025-01-14_13:02_UTC, License: Creative Commons Attribution 4.0 International, URL: https://bugsigdb.org
 BSDB ID,Study,Study design,PMID,DOI,URL,Authors list,Title,Journal,Year,Keywords,Experiment,Location of subjects,Host species,Body site,UBERON ID,Condition,EFO ID,Group 0 name,Group 1 name,Group 1 definition,Group 0 sample size,Group 1 sample size,Antibiotics exclusion,Sequencing type,16S variable region,Sequencing platform,Statistical test,Significance threshold,MHT correction,LDA Score above,Matched on,Confounders controlled for,Pielou,Shannon,Chao1,Simpson,Inverse Simpson,Richness,Signature page name,Source,Curated date,Curator,Revision editor,Description,Abundance in Group 1,MetaPhlAn taxon names,NCBI Taxonomy IDs,State,Reviewer
 bsdb:1/1/1,Study 1,case-control,28038683,10.1186/s40168-016-0218-6,NA,"Peters BA, Dominianni C, Shapiro JA, Church TR, Wu J, Miller G, Yuen E, Freiman H, Lustbader I, Salik J, Friedlander C, Hayes RB , Ahn J",The gut microbiota in conventional and serrated precursors of colorectal cancer,Microbiome,2016,"Adenoma, Cancer, Colorectal, Microbiome, Microbiota, Polyp, Serrated",Experiment 1,United States of America,Homo sapiens,Feces,UBERON:0001988,Colorectal adenoma,EFO:0005406,controls,conventional adenoma cases,"conventional adenoma cases; those with at least one tubular or tubulovillous adenoma and no other polyps of hyperplastic, SSA, or unclassified histology. HP cases; having at least one HP, with no other polyps of tubular, tubulovillous, SSA, or unclassified histology. SSA cases; having at least one SSA, with or without HP(s), and with no other polyps of tubular, tubulovillous, or unclassified histology. Proximal polyps; polyps located in the cecum, ascending colon, hepatic flexure, transverse colon, or splenic flexure. Distal polyps; polyps located in the descending colon, sigmoid colon, or rectum.",323,144,NYU included who had not been on long-term antibiotic treatment,16S,4,Illumina,DESeq2,0.1,TRUE,NA,NA,"age,body mass index,sex",NA,decreased,NA,NA,NA,decreased,Signature 1,Table 2 + Supplemental Table S5 + S3+ S4,10 January 2021,Levi Waldron,WikiWorks,"Differential abundance was detected by the “DESeq” function in the DESeq2 package. All classes and genera with an FDR-adjusted q < 0.10 are included in the table. Models were adjusted for sex, age, study, and categorical BMI. See Additional file 1: Table S5 for comparisons at the phylum, order, and family level",increased,"k__Bacteria|p__Bacillota|c__Bacilli,k__Bacteria|p__Pseudomonadota|c__Gammaproteobacteria,k__Bacteria|p__Actinomycetota|c__Actinomycetes|o__Actinomycetales|f__Actinomycetaceae|g__Actinomyces,k__Bacteria|p__Actinomycetota|c__Actinomycetes|o__Mycobacteriales|f__Corynebacteriaceae|g__Corynebacterium,k__Bacteria|p__Bacillota|c__Bacilli|o__Lactobacillales|f__Streptococcaceae|g__Streptococcus,k__Bacteria|p__Bacillota|c__Tissierellia|o__Tissierellales|f__Peptoniphilaceae|g__Peptoniphilus,k__Bacteria|p__Bacillota|c__Clostridia|o__Lachnospirales|f__Lachnospiraceae|g__Dorea,k__Bacteria|p__Bacillota|c__Negativicutes|o__Acidaminococcales|f__Acidaminococcaceae|g__Phascolarctobacterium,k__Bacteria|p__Pseudomonadota|c__Betaproteobacteria|o__Burkholderiales|f__Sutterellaceae|g__Sutterella,k__Bacteria|p__Actinomycetota|c__Actinomycetes|o__Actinomycetales,k__Bacteria|p__Actinomycetota|c__Actinomycetes|o__Actinomycetales|f__Actinomycetaceae,k__Bacteria|p__Pseudomonadota|c__Betaproteobacteria|o__Burkholderiales|f__Alcaligenaceae,k__Bacteria|p__Bacillota|c__Bacilli|o__Lactobacillales,k__Bacteria|p__Bacillota|c__Bacilli|o__Lactobacillales|f__Streptococcaceae,k__Bacteria|p__Bacillota|c__Negativicutes|o__Veillonellales|f__Veillonellaceae,k__Bacteria|p__Pseudomonadota|c__Gammaproteobacteria|o__Enterobacterales,k__Bacteria|p__Actinomycetota|c__Actinomycetes|o__Mycobacteriales|f__Corynebacteriaceae,k__Bacteria|p__Bacillota|c__Bacilli|o__Lactobacillales|f__Lactobacillaceae|g__Lacticaseibacillus|s__Lacticaseibacillus zeae,k__Bacteria|p__Bacillota|c__Bacilli|o__Bacillales|f__Bacillaceae|g__Bacillus,k__Bacteria|p__Bacillota|c__Bacilli|o__Bacillales|f__Bacillaceae",2|1239|91061;2|1224|1236;2|201174|1760|2037|2049|1654;2|201174|1760|85007|1653|1716;2|1239|91061|186826|1300|1301;2|1239|1737404|1737405|1570339|162289;2|1239|186801|3085636|186803|189330;2|1239|909932|1843488|909930|33024;2|1224|28216|80840|995019|40544;2|201174|1760|2037;2|201174|1760|2037|2049;2|1224|28216|80840|506;2|1239|91061|186826;2|1239|91061|186826|1300;2|1239|909932|1843489|31977;2|1224|1236|91347;2|201174|1760|85007|1653;2|1239|91061|186826|33958|2759736|57037;2|1239|91061|1385|186817|1386;2|1239|91061|1385|186817,Complete,Fatima
 bsdb:1/1/2,Study 1,case-control,28038683,10.1186/s40168-016-0218-6,NA,"Peters BA, Dominianni C, Shapiro JA, Church TR, Wu J, Miller G, Yuen E, Freiman H, Lustbader I, Salik J, Friedlander C, Hayes RB , Ahn J",The gut microbiota in conventional and serrated precursors of colorectal cancer,Microbiome,2016,"Adenoma, Cancer, Colorectal, Microbiome, Microbiota, Polyp, Serrated",Experiment 1,United States of America,Homo sapiens,Feces,UBERON:0001988,Colorectal adenoma,EFO:0005406,controls,conventional adenoma cases,"conventional adenoma cases; those with at least one tubular or tubulovillous adenoma and no other polyps of hyperplastic, SSA, or unclassified histology. HP cases; having at least one HP, with no other polyps of tubular, tubulovillous, SSA, or unclassified histology. SSA cases; having at least one SSA, with or without HP(s), and with no other polyps of tubular, tubulovillous, or unclassified histology. Proximal polyps; polyps located in the cecum, ascending colon, hepatic flexure, transverse colon, or splenic flexure. Distal polyps; polyps located in the descending colon, sigmoid colon, or rectum.",323,144,NYU included who had not been on long-term antibiotic treatment,16S,4,Illumina,DESeq2,0.1,TRUE,NA,NA,"age,body mass index,sex",NA,decreased,NA,NA,NA,decreased,Signature 2,Table 2 + Supplemental Table S5 + S3+ S4,10 January 2021,Levi Waldron,WikiWorks,"Differential abundance was detected by the “DESeq” function in the DESeq2 package. All classes and genera with an FDR-adjusted q < 0.10 are included in the table. Models were adjusted for sex, age, study, and categorical BMI. See Additional file 1: Table S5 for comparisons at the phylum, order, and family level",decreased,"k__Bacteria|p__Bacillota|c__Erysipelotrichia|o__Erysipelotrichales|f__Coprobacillaceae|g__Coprobacillus,k__Bacteria|p__Cyanobacteriota",2|1239|526524|526525|2810280|100883;2|1117,Complete,Shaimaa Elsafoury
@@ -6010,12 +6010,12 @@ bsdb:1086/6/1,Study 1086,case-control,38745393,10.1111/jcpe.13998,NA,"Bingöl M,
 bsdb:1086/6/2,Study 1086,case-control,38745393,10.1111/jcpe.13998,NA,"Bingöl M, Cardilli A, Bingöl AC, Löber U, Bang C, Franke A, Bartzela T, Beblo S, Mönch E, Stolz S, Schaefer AS, Forslund SK , Richter GM",Oral microbiota of patients with phenylketonuria: A nation-based cross-sectional study,Journal of clinical periodontology,2024,"16s rDNA sequencing, periodontitis, phenylketonuria, saliva, subgingival plaque",Experiment 6,Germany,Homo sapiens,Subgingival dental plaque,UBERON:0016484,Phenylketonuria,MONDO:0009861,Control Children subgingival plaque (Ctrl-Ch-SP) patients,Phenylketonuria Children subgingival plaque (PKU-Ch-SP) patients,Children Patients diagnosed with Phenylketonuria (PKU) and who stimulated Sub gingival plaque samples were gotten from.,61,51,NA,16S,12,Illumina,Mann-Whitney (Wilcoxon),0.05,TRUE,NA,age,NA,unchanged,unchanged,NA,NA,NA,unchanged,Signature 2,Appendix Table 5,12 August 2024,MyleeeA,MyleeeA,Differential abundant genera in Phenylketonuria (PKU-Ch-SP) and Control (Ctrl-Ch-SP) Children Subgingival plague Patients.,decreased,"k__Bacteria|k__Pseudomonadati|p__Pseudomonadota|c__Gammaproteobacteria|o__Pasteurellales|f__Pasteurellaceae|g__Aggregatibacter,k__Bacteria|k__Pseudomonadati|p__Bacteroidota|c__Flavobacteriia|o__Flavobacteriales|f__Flavobacteriaceae|g__Capnocytophaga,k__Bacteria|k__Bacillati|p__Bacillota|c__Bacilli|o__Bacillales|f__Gemellaceae|g__Gemella,k__Bacteria|k__Fusobacteriati|p__Fusobacteriota|c__Fusobacteriia|o__Fusobacteriales|f__Leptotrichiaceae|g__Leptotrichia",2|3379134|1224|1236|135625|712|416916;2|3379134|976|117743|200644|49546|1016;2|1783272|1239|91061|1385|539738|1378;2|3384189|32066|203490|203491|1129771|32067,Complete,NA
 bsdb:1086/7/1,Study 1086,case-control,38745393,10.1111/jcpe.13998,NA,"Bingöl M, Cardilli A, Bingöl AC, Löber U, Bang C, Franke A, Bartzela T, Beblo S, Mönch E, Stolz S, Schaefer AS, Forslund SK , Richter GM",Oral microbiota of patients with phenylketonuria: A nation-based cross-sectional study,Journal of clinical periodontology,2024,"16s rDNA sequencing, periodontitis, phenylketonuria, saliva, subgingival plaque",Experiment 7,Germany,Homo sapiens,Saliva,UBERON:0001836,Phenylketonuria,MONDO:0009861,ChCtrlRel-S [related control children saliva (Healthy siblings of PKU patients)],ChCtrlUnrel-S (unrelated control children saliva) patients,Control Children unrelated to Phenylketonuria (PKU) patients who stimulated saliva samples were gotten from.,12,26,NA,16S,12,Illumina,Mann-Whitney (Wilcoxon),0.05,TRUE,NA,age,NA,decreased,unchanged,NA,NA,NA,increased,Signature 1,Appendix Table 5,13 August 2024,MyleeeA,"MyleeeA,Tosin",Differential abundant genera in ChCtrlRel-S (related control children saliva) and ChCtrlUnrel-S (unrelated control children saliva) to Phenylketonuria Patients.,increased,"k__Bacteria|k__Pseudomonadati|p__Pseudomonadota|c__Gammaproteobacteria|o__Pasteurellales|f__Pasteurellaceae|g__Haemophilus,k__Bacteria|k__Bacillati|p__Bacillota|c__Clostridia|o__Lachnospirales|f__Lachnospiraceae|g__Lachnoanaerobaculum,k__Bacteria|k__Bacillati|p__Bacillota|c__Clostridia|o__Lachnospirales|f__Lachnospiraceae|g__Oribacterium",2|3379134|1224|1236|135625|712|724;2|1783272|1239|186801|3085636|186803|1164882;2|1783272|1239|186801|3085636|186803|265975,Complete,NA
 bsdb:1086/7/2,Study 1086,case-control,38745393,10.1111/jcpe.13998,NA,"Bingöl M, Cardilli A, Bingöl AC, Löber U, Bang C, Franke A, Bartzela T, Beblo S, Mönch E, Stolz S, Schaefer AS, Forslund SK , Richter GM",Oral microbiota of patients with phenylketonuria: A nation-based cross-sectional study,Journal of clinical periodontology,2024,"16s rDNA sequencing, periodontitis, phenylketonuria, saliva, subgingival plaque",Experiment 7,Germany,Homo sapiens,Saliva,UBERON:0001836,Phenylketonuria,MONDO:0009861,ChCtrlRel-S [related control children saliva (Healthy siblings of PKU patients)],ChCtrlUnrel-S (unrelated control children saliva) patients,Control Children unrelated to Phenylketonuria (PKU) patients who stimulated saliva samples were gotten from.,12,26,NA,16S,12,Illumina,Mann-Whitney (Wilcoxon),0.05,TRUE,NA,age,NA,decreased,unchanged,NA,NA,NA,increased,Signature 2,Appendix Table 5,13 August 2024,MyleeeA,MyleeeA,Differential abundant genera in ChCtrlRel-S (related control children saliva) and ChCtrlUnrel-S (unrelated control children saliva) to Phenylketonuria Patients.,decreased,"k__Bacteria|k__Bacillati|p__Actinomycetota|c__Actinomycetes|o__Actinomycetales|f__Actinomycetaceae|g__Actinomyces,k__Bacteria|k__Bacillati|p__Actinomycetota|c__Actinomycetes|o__Propionibacteriales|f__Propionibacteriaceae|g__Arachnia,k__Bacteria|k__Bacillati|p__Actinomycetota|c__Coriobacteriia|o__Coriobacteriales|f__Atopobiaceae|g__Atopobium,k__Bacteria|k__Thermotogati|p__Synergistota|c__Synergistia|o__Synergistales|f__Aminobacteriaceae|g__Fretibacterium,k__Bacteria|k__Pseudomonadati|p__Pseudomonadota|c__Betaproteobacteria|o__Burkholderiales|f__Burkholderiaceae|g__Lautropia,k__Bacteria|k__Bacillati|p__Bacillota|c__Clostridia|o__Peptostreptococcales|f__Peptostreptococcaceae|g__Peptostreptococcus",2|1783272|201174|1760|2037|2049|1654;2|1783272|201174|1760|85009|31957|2801844;2|1783272|201174|84998|84999|1643824|1380;2|3384194|508458|649775|649776|3029087|1434006;2|3379134|1224|28216|80840|119060|47670;2|1783272|1239|186801|3082720|186804|1257,Complete,NA
-bsdb:1086/8/1,Study 1086,case-control,38745393,10.1111/jcpe.13998,NA,"Bingöl M, Cardilli A, Bingöl AC, Löber U, Bang C, Franke A, Bartzela T, Beblo S, Mönch E, Stolz S, Schaefer AS, Forslund SK , Richter GM",Oral microbiota of patients with phenylketonuria: A nation-based cross-sectional study,Journal of clinical periodontology,2024,"16s rDNA sequencing, periodontitis, phenylketonuria, saliva, subgingival plaque",Experiment 8,Germany,Homo sapiens,Saliva,UBERON:0001836,Phenylketonuria,MONDO:0009861,Ch CTRL rel (Healthy siblings of PKU patients),Ch PKU (PKU children),Children diagnosed with Phenylketonuria (PKU) and who stimulated Saliva samples were gotten from.,12,59,NA,16S,12,Illumina,Mann-Whitney (Wilcoxon),0.05,TRUE,NA,age,NA,unchanged,unchanged,NA,NA,NA,unchanged,Signature 1,Figure 2(D),13 August 2024,MyleeeA,MyleeeA,Differential abundant genera in Ch-CTRL-related and Phenylketonuria (PKU-Ch) Saliva Patients.,increased,"k__Bacteria|p__Bacteroidota|c__Flavobacteriia|o__Flavobacteriales|f__Flavobacteriaceae|g__Capnocytophaga,k__Bacteria|p__Bacillota|c__Clostridia|o__Peptostreptococcales|f__Peptostreptococcaceae|g__Peptostreptococcus,k__Bacteria|p__Bacillota|c__Clostridia|o__Eubacteriales|f__Peptococcaceae|g__Peptococcus,k__Bacteria|p__Fusobacteriota|c__Fusobacteriia|o__Fusobacteriales|f__Leptotrichiaceae|g__Leptotrichia,k__Bacteria|p__Bacillota|c__Clostridia|o__Lachnospirales|f__Lachnospiraceae|g__Lachnoanaerobaculum,k__Bacteria|p__Bacteroidota|c__Bacteroidia|o__Bacteroidales|f__Porphyromonadaceae|g__Porphyromonas,k__Bacteria|p__Pseudomonadota|c__Gammaproteobacteria|o__Pasteurellales|f__Pasteurellaceae|g__Aggregatibacter",2|976|117743|200644|49546|1016;2|1239|186801|3082720|186804|1257;2|1239|186801|186802|186807|2740;2|32066|203490|203491|1129771|32067;2|1239|186801|3085636|186803|1164882;2|976|200643|171549|171551|836;2|1224|1236|135625|712|416916,Complete,NA
-bsdb:1086/8/2,Study 1086,case-control,38745393,10.1111/jcpe.13998,NA,"Bingöl M, Cardilli A, Bingöl AC, Löber U, Bang C, Franke A, Bartzela T, Beblo S, Mönch E, Stolz S, Schaefer AS, Forslund SK , Richter GM",Oral microbiota of patients with phenylketonuria: A nation-based cross-sectional study,Journal of clinical periodontology,2024,"16s rDNA sequencing, periodontitis, phenylketonuria, saliva, subgingival plaque",Experiment 8,Germany,Homo sapiens,Saliva,UBERON:0001836,Phenylketonuria,MONDO:0009861,Ch CTRL rel (Healthy siblings of PKU patients),Ch PKU (PKU children),Children diagnosed with Phenylketonuria (PKU) and who stimulated Saliva samples were gotten from.,12,59,NA,16S,12,Illumina,Mann-Whitney (Wilcoxon),0.05,TRUE,NA,age,NA,unchanged,unchanged,NA,NA,NA,unchanged,Signature 2,Figure 2(D),13 August 2024,MyleeeA,MyleeeA,Differential abundant genera in Ch-CTRL-related and Phenylketonuria (PKU-Ch) Saliva Patients.,decreased,"k__Bacteria|p__Actinomycetota|c__Coriobacteriia|o__Coriobacteriales|f__Atopobiaceae|g__Olsenella,k__Bacteria|p__Bacillota|c__Negativicutes|o__Selenomonadales|f__Selenomonadaceae|g__Selenomonas,k__Bacteria|p__Actinomycetota|c__Coriobacteriia|o__Coriobacteriales|f__Atopobiaceae|g__Atopobium,k__Bacteria|p__Actinomycetota|c__Actinomycetes|o__Actinomycetales|f__Actinomycetaceae|g__Actinomyces,k__Bacteria|p__Synergistota|c__Synergistia|o__Synergistales|f__Aminobacteriaceae|g__Fretibacterium",2|201174|84998|84999|1643824|133925;2|1239|909932|909929|1843491|970;2|201174|84998|84999|1643824|1380;2|201174|1760|2037|2049|1654;2|508458|649775|649776|3029087|1434006,Complete,NA
-bsdb:1086/9/1,Study 1086,case-control,38745393,10.1111/jcpe.13998,NA,"Bingöl M, Cardilli A, Bingöl AC, Löber U, Bang C, Franke A, Bartzela T, Beblo S, Mönch E, Stolz S, Schaefer AS, Forslund SK , Richter GM",Oral microbiota of patients with phenylketonuria: A nation-based cross-sectional study,Journal of clinical periodontology,2024,"16s rDNA sequencing, periodontitis, phenylketonuria, saliva, subgingival plaque",Experiment 9,Germany,Homo sapiens,Mouth,UBERON:0000165,Phenylketonuria,MONDO:0009861,Control (CTRL-S),Control (CTRL-SP),Healthy Controls who stimulated Subgingival plaque samples were gotten from.,114,113,NA,16S,12,Illumina,Mann-Whitney (Wilcoxon),0.05,TRUE,NA,age,NA,NA,NA,NA,NA,NA,NA,Signature 1,Figure 2(D),12 August 2024,MyleeeA,MyleeeA,Differential abundant genera in Control Saliva and Control Subgingival Plague samples,increased,"k__Bacteria|p__Bacillota|c__Negativicutes|o__Veillonellales|f__Veillonellaceae|g__Veillonella,k__Bacteria|p__Bacillota|c__Bacilli|o__Lactobacillales|f__Streptococcaceae|g__Streptococcus,k__Bacteria|p__Bacillota|c__Clostridia|o__Lachnospirales|f__Lachnospiraceae|g__Stomatobaculum,k__Bacteria|p__Bacillota|c__Clostridia|o__Peptostreptococcales|f__Peptostreptococcaceae|g__Peptostreptococcus,k__Bacteria|p__Pseudomonadota|c__Gammaproteobacteria|o__Pasteurellales|f__Pasteurellaceae|g__Haemophilus,k__Bacteria|p__Bacillota|c__Bacilli|o__Bacillales|f__Gemellaceae|g__Gemella,k__Bacteria|p__Actinomycetota|c__Coriobacteriia|o__Coriobacteriales|f__Atopobiaceae|g__Atopobium,k__Bacteria|p__Bacteroidota|c__Bacteroidia|o__Bacteroidales|f__Prevotellaceae|g__Alloprevotella,k__Bacteria|p__Pseudomonadota|c__Betaproteobacteria|o__Neisseriales|f__Neisseriaceae|g__Neisseria,k__Bacteria|p__Bacteroidota|c__Bacteroidia|o__Bacteroidales|f__Porphyromonadaceae|g__Porphyromonas,k__Bacteria|p__Bacillota|c__Clostridia|o__Lachnospirales|f__Lachnospiraceae|g__Oribacterium,k__Bacteria|p__Bacteroidota|c__Bacteroidia|o__Bacteroidales|f__Prevotellaceae|g__Prevotella",2|1239|909932|1843489|31977|29465;2|1239|91061|186826|1300|1301;2|1239|186801|3085636|186803|1213720;2|1239|186801|3082720|186804|1257;2|1224|1236|135625|712|724;2|1239|91061|1385|539738|1378;2|201174|84998|84999|1643824|1380;2|976|200643|171549|171552|1283313;2|1224|28216|206351|481|482;2|976|200643|171549|171551|836;2|1239|186801|3085636|186803|265975;2|976|200643|171549|171552|838,Complete,NA
-bsdb:1086/9/2,Study 1086,case-control,38745393,10.1111/jcpe.13998,NA,"Bingöl M, Cardilli A, Bingöl AC, Löber U, Bang C, Franke A, Bartzela T, Beblo S, Mönch E, Stolz S, Schaefer AS, Forslund SK , Richter GM",Oral microbiota of patients with phenylketonuria: A nation-based cross-sectional study,Journal of clinical periodontology,2024,"16s rDNA sequencing, periodontitis, phenylketonuria, saliva, subgingival plaque",Experiment 9,Germany,Homo sapiens,Mouth,UBERON:0000165,Phenylketonuria,MONDO:0009861,Control (CTRL-S),Control (CTRL-SP),Healthy Controls who stimulated Subgingival plaque samples were gotten from.,114,113,NA,16S,12,Illumina,Mann-Whitney (Wilcoxon),0.05,TRUE,NA,age,NA,NA,NA,NA,NA,NA,NA,Signature 2,Figure 2(D),12 August 2024,MyleeeA,MyleeeA,Differential abundant genera in Control Saliva and Control Subgingival plague,decreased,"k__Bacteria|p__Pseudomonadota|c__Gammaproteobacteria|o__Pasteurellales|f__Pasteurellaceae|g__Aggregatibacter,k__Bacteria|p__Actinomycetota|c__Actinomycetes|o__Propionibacteriales|f__Propionibacteriaceae|g__Arachnia,k__Bacteria|p__Campylobacterota|c__Epsilonproteobacteria|o__Campylobacterales|f__Campylobacteraceae|g__Campylobacter,k__Bacteria|p__Bacteroidota|c__Flavobacteriia|o__Flavobacteriales|f__Flavobacteriaceae|g__Capnocytophaga,k__Bacteria|p__Pseudomonadota|c__Gammaproteobacteria|o__Cardiobacteriales|f__Cardiobacteriaceae|g__Cardiobacterium,k__Bacteria|p__Actinomycetota|c__Actinomycetes|o__Mycobacteriales|f__Corynebacteriaceae|g__Corynebacterium,k__Bacteria|p__Fusobacteriota|c__Fusobacteriia|o__Fusobacteriales|f__Fusobacteriaceae|g__Fusobacterium,k__Bacteria|p__Pseudomonadota|c__Betaproteobacteria|o__Neisseriales|f__Neisseriaceae|g__Kingella,k__Bacteria|p__Fusobacteriota|c__Fusobacteriia|o__Fusobacteriales|f__Leptotrichiaceae|g__Leptotrichia,k__Bacteria|p__Actinomycetota|c__Coriobacteriia|o__Coriobacteriales|f__Atopobiaceae|g__Olsenella,k__Bacteria|p__Bacillota|c__Negativicutes|o__Selenomonadales|f__Selenomonadaceae|g__Selenomonas,k__Bacteria|p__Bacteroidota|c__Bacteroidia|o__Bacteroidales|f__Tannerellaceae|g__Tannerella",2|1224|1236|135625|712|416916;2|201174|1760|85009|31957|2801844;2|29547|3031852|213849|72294|194;2|976|117743|200644|49546|1016;2|1224|1236|135615|868|2717;2|201174|1760|85007|1653|1716;2|32066|203490|203491|203492|848;2|1224|28216|206351|481|32257;2|32066|203490|203491|1129771|32067;2|201174|84998|84999|1643824|133925;2|1239|909932|909929|1843491|970;2|976|200643|171549|2005525|195950,Complete,NA
-bsdb:1086/10/1,Study 1086,case-control,38745393,10.1111/jcpe.13998,NA,"Bingöl M, Cardilli A, Bingöl AC, Löber U, Bang C, Franke A, Bartzela T, Beblo S, Mönch E, Stolz S, Schaefer AS, Forslund SK , Richter GM",Oral microbiota of patients with phenylketonuria: A nation-based cross-sectional study,Journal of clinical periodontology,2024,"16s rDNA sequencing, periodontitis, phenylketonuria, saliva, subgingival plaque",Experiment 10,Germany,Homo sapiens,Mouth,UBERON:0000165,Phenylketonuria,MONDO:0009861,Control Adults (CTRL-S),Control Adults (CTRL-SP),Healthy Control adults who stimulated Sub gingival plaque samples were gotten from,52,52,NA,16S,12,Illumina,Mann-Whitney (Wilcoxon),0.05,TRUE,NA,age,NA,NA,NA,NA,NA,NA,NA,Signature 1,Figure 2(D),12 August 2024,MyleeeA,MyleeeA,Differential abundant genera in Control Saliva and Control Subgingival plague Adult samples,increased,"k__Bacteria|p__Bacillota|c__Negativicutes|o__Veillonellales|f__Veillonellaceae|g__Veillonella,k__Bacteria|p__Bacillota|c__Bacilli|o__Lactobacillales|f__Streptococcaceae|g__Streptococcus,k__Bacteria|p__Bacillota|c__Clostridia|o__Lachnospirales|f__Lachnospiraceae|g__Stomatobaculum,k__Bacteria|p__Bacillota|c__Clostridia|o__Peptostreptococcales|f__Peptostreptococcaceae|g__Peptostreptococcus,k__Bacteria|p__Pseudomonadota|c__Gammaproteobacteria|o__Pasteurellales|f__Pasteurellaceae|g__Haemophilus,k__Bacteria|p__Bacillota|c__Bacilli|o__Bacillales|f__Gemellaceae|g__Gemella,k__Bacteria|p__Actinomycetota|c__Coriobacteriia|o__Coriobacteriales|f__Atopobiaceae|g__Atopobium,k__Bacteria|p__Bacteroidota|c__Bacteroidia|o__Bacteroidales|f__Prevotellaceae|g__Alloprevotella,k__Bacteria|p__Pseudomonadota|c__Betaproteobacteria|o__Neisseriales|f__Neisseriaceae|g__Neisseria,k__Bacteria|p__Bacteroidota|c__Bacteroidia|o__Bacteroidales|f__Porphyromonadaceae|g__Porphyromonas,k__Bacteria|p__Bacillota|c__Clostridia|o__Lachnospirales|f__Lachnospiraceae|g__Oribacterium,k__Bacteria|p__Bacteroidota|c__Bacteroidia|o__Bacteroidales|f__Prevotellaceae|g__Prevotella",2|1239|909932|1843489|31977|29465;2|1239|91061|186826|1300|1301;2|1239|186801|3085636|186803|1213720;2|1239|186801|3082720|186804|1257;2|1224|1236|135625|712|724;2|1239|91061|1385|539738|1378;2|201174|84998|84999|1643824|1380;2|976|200643|171549|171552|1283313;2|1224|28216|206351|481|482;2|976|200643|171549|171551|836;2|1239|186801|3085636|186803|265975;2|976|200643|171549|171552|838,Complete,NA
-bsdb:1086/10/2,Study 1086,case-control,38745393,10.1111/jcpe.13998,NA,"Bingöl M, Cardilli A, Bingöl AC, Löber U, Bang C, Franke A, Bartzela T, Beblo S, Mönch E, Stolz S, Schaefer AS, Forslund SK , Richter GM",Oral microbiota of patients with phenylketonuria: A nation-based cross-sectional study,Journal of clinical periodontology,2024,"16s rDNA sequencing, periodontitis, phenylketonuria, saliva, subgingival plaque",Experiment 10,Germany,Homo sapiens,Mouth,UBERON:0000165,Phenylketonuria,MONDO:0009861,Control Adults (CTRL-S),Control Adults (CTRL-SP),Healthy Control adults who stimulated Sub gingival plaque samples were gotten from,52,52,NA,16S,12,Illumina,Mann-Whitney (Wilcoxon),0.05,TRUE,NA,age,NA,NA,NA,NA,NA,NA,NA,Signature 2,Figure 2(D),12 August 2024,MyleeeA,MyleeeA,Differential abundant genera in Control Saliva and Control Subgingival plague Adult samples,decreased,"k__Bacteria|p__Pseudomonadota|c__Gammaproteobacteria|o__Pasteurellales|f__Pasteurellaceae|g__Aggregatibacter,k__Bacteria|p__Actinomycetota|c__Actinomycetes|o__Propionibacteriales|f__Propionibacteriaceae|g__Arachnia,k__Bacteria|p__Campylobacterota|c__Epsilonproteobacteria|o__Campylobacterales|f__Campylobacteraceae|g__Campylobacter,k__Bacteria|p__Bacteroidota|c__Flavobacteriia|o__Flavobacteriales|f__Flavobacteriaceae|g__Capnocytophaga,k__Bacteria|p__Pseudomonadota|c__Gammaproteobacteria|o__Cardiobacteriales|f__Cardiobacteriaceae|g__Cardiobacterium,k__Bacteria|p__Actinomycetota|c__Actinomycetes|o__Mycobacteriales|f__Corynebacteriaceae|g__Corynebacterium,k__Bacteria|p__Fusobacteriota|c__Fusobacteriia|o__Fusobacteriales|f__Fusobacteriaceae|g__Fusobacterium,k__Bacteria|p__Pseudomonadota|c__Betaproteobacteria|o__Neisseriales|f__Neisseriaceae|g__Kingella,k__Bacteria|p__Actinomycetota|c__Coriobacteriia|o__Coriobacteriales|f__Atopobiaceae|g__Olsenella,k__Bacteria|p__Bacillota|c__Negativicutes|o__Selenomonadales|f__Selenomonadaceae|g__Selenomonas,k__Bacteria|p__Bacteroidota|c__Bacteroidia|o__Bacteroidales|f__Tannerellaceae|g__Tannerella",2|1224|1236|135625|712|416916;2|201174|1760|85009|31957|2801844;2|29547|3031852|213849|72294|194;2|976|117743|200644|49546|1016;2|1224|1236|135615|868|2717;2|201174|1760|85007|1653|1716;2|32066|203490|203491|203492|848;2|1224|28216|206351|481|32257;2|201174|84998|84999|1643824|133925;2|1239|909932|909929|1843491|970;2|976|200643|171549|2005525|195950,Complete,NA
+bsdb:1086/8/1,Study 1086,case-control,38745393,10.1111/jcpe.13998,NA,"Bingöl M, Cardilli A, Bingöl AC, Löber U, Bang C, Franke A, Bartzela T, Beblo S, Mönch E, Stolz S, Schaefer AS, Forslund SK , Richter GM",Oral microbiota of patients with phenylketonuria: A nation-based cross-sectional study,Journal of clinical periodontology,2024,"16s rDNA sequencing, periodontitis, phenylketonuria, saliva, subgingival plaque",Experiment 8,Germany,Homo sapiens,Saliva,UBERON:0001836,Phenylketonuria,MONDO:0009861,ChCtrlRel-S [related control children saliva (Healthy siblings of PKU patients)],ChPKU-S (PKU children saliva) patients,Children diagnosed with Phenylketonuria (PKU) and who stimulated Saliva samples were gotten from.,12,59,NA,16S,12,Illumina,Mann-Whitney (Wilcoxon),0.05,TRUE,NA,age,NA,unchanged,unchanged,NA,NA,NA,unchanged,Signature 1,Figure 2(D),13 August 2024,MyleeeA,MyleeeA,Differential abundant genera in Ch-CTRL-related and Phenylketonuria (PKU-Ch) Saliva Patients.,increased,"k__Bacteria|p__Bacteroidota|c__Flavobacteriia|o__Flavobacteriales|f__Flavobacteriaceae|g__Capnocytophaga,k__Bacteria|p__Bacillota|c__Clostridia|o__Peptostreptococcales|f__Peptostreptococcaceae|g__Peptostreptococcus,k__Bacteria|p__Bacillota|c__Clostridia|o__Eubacteriales|f__Peptococcaceae|g__Peptococcus,k__Bacteria|p__Fusobacteriota|c__Fusobacteriia|o__Fusobacteriales|f__Leptotrichiaceae|g__Leptotrichia,k__Bacteria|p__Bacillota|c__Clostridia|o__Lachnospirales|f__Lachnospiraceae|g__Lachnoanaerobaculum,k__Bacteria|p__Bacteroidota|c__Bacteroidia|o__Bacteroidales|f__Porphyromonadaceae|g__Porphyromonas,k__Bacteria|p__Pseudomonadota|c__Gammaproteobacteria|o__Pasteurellales|f__Pasteurellaceae|g__Aggregatibacter",2|976|117743|200644|49546|1016;2|1239|186801|3082720|186804|1257;2|1239|186801|186802|186807|2740;2|32066|203490|203491|1129771|32067;2|1239|186801|3085636|186803|1164882;2|976|200643|171549|171551|836;2|1224|1236|135625|712|416916,Complete,NA
+bsdb:1086/8/2,Study 1086,case-control,38745393,10.1111/jcpe.13998,NA,"Bingöl M, Cardilli A, Bingöl AC, Löber U, Bang C, Franke A, Bartzela T, Beblo S, Mönch E, Stolz S, Schaefer AS, Forslund SK , Richter GM",Oral microbiota of patients with phenylketonuria: A nation-based cross-sectional study,Journal of clinical periodontology,2024,"16s rDNA sequencing, periodontitis, phenylketonuria, saliva, subgingival plaque",Experiment 8,Germany,Homo sapiens,Saliva,UBERON:0001836,Phenylketonuria,MONDO:0009861,ChCtrlRel-S [related control children saliva (Healthy siblings of PKU patients)],ChPKU-S (PKU children saliva) patients,Children diagnosed with Phenylketonuria (PKU) and who stimulated Saliva samples were gotten from.,12,59,NA,16S,12,Illumina,Mann-Whitney (Wilcoxon),0.05,TRUE,NA,age,NA,unchanged,unchanged,NA,NA,NA,unchanged,Signature 2,Figure 2(D),13 August 2024,MyleeeA,MyleeeA,Differential abundant genera in Ch-CTRL-related and Phenylketonuria (PKU-Ch) Saliva Patients.,decreased,"k__Bacteria|p__Actinomycetota|c__Coriobacteriia|o__Coriobacteriales|f__Atopobiaceae|g__Olsenella,k__Bacteria|p__Bacillota|c__Negativicutes|o__Selenomonadales|f__Selenomonadaceae|g__Selenomonas,k__Bacteria|p__Actinomycetota|c__Coriobacteriia|o__Coriobacteriales|f__Atopobiaceae|g__Atopobium,k__Bacteria|p__Actinomycetota|c__Actinomycetes|o__Actinomycetales|f__Actinomycetaceae|g__Actinomyces,k__Bacteria|p__Synergistota|c__Synergistia|o__Synergistales|f__Aminobacteriaceae|g__Fretibacterium",2|201174|84998|84999|1643824|133925;2|1239|909932|909929|1843491|970;2|201174|84998|84999|1643824|1380;2|201174|1760|2037|2049|1654;2|508458|649775|649776|3029087|1434006,Complete,NA
+bsdb:1086/9/1,Study 1086,case-control,38745393,10.1111/jcpe.13998,NA,"Bingöl M, Cardilli A, Bingöl AC, Löber U, Bang C, Franke A, Bartzela T, Beblo S, Mönch E, Stolz S, Schaefer AS, Forslund SK , Richter GM",Oral microbiota of patients with phenylketonuria: A nation-based cross-sectional study,Journal of clinical periodontology,2024,"16s rDNA sequencing, periodontitis, phenylketonuria, saliva, subgingival plaque",Experiment 9,Germany,Homo sapiens,Mouth,UBERON:0000165,Phenylketonuria,MONDO:0009861,Control Saliva (Ctrl-S) patients,Control Subgingival plaque (Ctrl-SP) patients,Healthy Controls who stimulated Subgingival plaque samples were gotten from.,114,113,NA,16S,12,Illumina,Mann-Whitney (Wilcoxon),0.05,TRUE,NA,age,NA,NA,NA,NA,NA,NA,NA,Signature 1,Appendix Table 10,12 August 2024,MyleeeA,"MyleeeA,Tosin",Differential abundant genera in Control Saliva (Ctrl-S) and Control Subgingival Plague (Ctrl-SP) patients,increased,"k__Bacteria|k__Pseudomonadati|p__Bacteroidota|c__Bacteroidia|o__Bacteroidales|f__Prevotellaceae|g__Alloprevotella,k__Bacteria|k__Bacillati|p__Actinomycetota|c__Coriobacteriia|o__Coriobacteriales|f__Atopobiaceae|g__Atopobium,k__Bacteria|k__Bacillati|p__Bacillota|c__Bacilli|o__Bacillales|f__Gemellaceae|g__Gemella,k__Bacteria|k__Pseudomonadati|p__Pseudomonadota|c__Gammaproteobacteria|o__Pasteurellales|f__Pasteurellaceae|g__Haemophilus,k__Bacteria|k__Pseudomonadati|p__Pseudomonadota|c__Betaproteobacteria|o__Neisseriales|f__Neisseriaceae|g__Neisseria,k__Bacteria|k__Bacillati|p__Bacillota|c__Clostridia|o__Lachnospirales|f__Lachnospiraceae|g__Oribacterium,k__Bacteria|k__Bacillati|p__Bacillota|c__Clostridia|o__Peptostreptococcales|f__Peptostreptococcaceae|g__Peptostreptococcus,k__Bacteria|k__Pseudomonadati|p__Bacteroidota|c__Bacteroidia|o__Bacteroidales|f__Porphyromonadaceae|g__Porphyromonas,k__Bacteria|k__Pseudomonadati|p__Bacteroidota|c__Bacteroidia|o__Bacteroidales|f__Prevotellaceae|g__Prevotella,k__Bacteria|k__Bacillati|p__Bacillota|c__Clostridia|o__Lachnospirales|f__Lachnospiraceae|g__Stomatobaculum,k__Bacteria|k__Bacillati|p__Bacillota|c__Bacilli|o__Lactobacillales|f__Streptococcaceae|g__Streptococcus,k__Bacteria|k__Bacillati|p__Bacillota|c__Negativicutes|o__Veillonellales|f__Veillonellaceae|g__Veillonella,k__Eukaryota|k__Viridiplantae|p__Streptophyta|c__Magnoliopsida|o__Fabales|f__Fabaceae|s__Papilionoideae|g__Rothia,k__Bacteria|k__Bacillati|p__Bacillota|c__Clostridia|o__Lachnospirales|f__Lachnospiraceae|g__Lachnoanaerobaculum",2|3379134|976|200643|171549|171552|1283313;2|1783272|201174|84998|84999|1643824|1380;2|1783272|1239|91061|1385|539738|1378;2|3379134|1224|1236|135625|712|724;2|3379134|1224|28216|206351|481|482;2|1783272|1239|186801|3085636|186803|265975;2|1783272|1239|186801|3082720|186804|1257;2|3379134|976|200643|171549|171551|836;2|3379134|976|200643|171549|171552|838;2|1783272|1239|186801|3085636|186803|1213720;2|1783272|1239|91061|186826|1300|1301;2|1783272|1239|909932|1843489|31977|29465;2759|33090|35493|3398|72025|3803|3814|508215;2|1783272|1239|186801|3085636|186803|1164882,Complete,NA
+bsdb:1086/9/2,Study 1086,case-control,38745393,10.1111/jcpe.13998,NA,"Bingöl M, Cardilli A, Bingöl AC, Löber U, Bang C, Franke A, Bartzela T, Beblo S, Mönch E, Stolz S, Schaefer AS, Forslund SK , Richter GM",Oral microbiota of patients with phenylketonuria: A nation-based cross-sectional study,Journal of clinical periodontology,2024,"16s rDNA sequencing, periodontitis, phenylketonuria, saliva, subgingival plaque",Experiment 9,Germany,Homo sapiens,Mouth,UBERON:0000165,Phenylketonuria,MONDO:0009861,Control Saliva (Ctrl-S) patients,Control Subgingival plaque (Ctrl-SP) patients,Healthy Controls who stimulated Subgingival plaque samples were gotten from.,114,113,NA,16S,12,Illumina,Mann-Whitney (Wilcoxon),0.05,TRUE,NA,age,NA,NA,NA,NA,NA,NA,NA,Signature 2,Appendix Table 10,12 August 2024,MyleeeA,"MyleeeA,Tosin",Differential abundant genera in Control Saliva (Ctrl-S) and Control Subgingival plague (Ctrl-SP) patients,decreased,"k__Bacteria|k__Pseudomonadati|p__Pseudomonadota|c__Gammaproteobacteria|o__Pasteurellales|f__Pasteurellaceae|g__Aggregatibacter,k__Bacteria|k__Bacillati|p__Actinomycetota|c__Actinomycetes|o__Propionibacteriales|f__Propionibacteriaceae|g__Arachnia,k__Bacteria|k__Pseudomonadati|p__Campylobacterota|c__Epsilonproteobacteria|o__Campylobacterales|f__Campylobacteraceae|g__Campylobacter,k__Bacteria|k__Pseudomonadati|p__Bacteroidota|c__Flavobacteriia|o__Flavobacteriales|f__Flavobacteriaceae|g__Capnocytophaga,k__Bacteria|k__Pseudomonadati|p__Pseudomonadota|c__Gammaproteobacteria|o__Cardiobacteriales|f__Cardiobacteriaceae|g__Cardiobacterium,k__Bacteria|k__Bacillati|p__Actinomycetota|c__Actinomycetes|o__Mycobacteriales|f__Corynebacteriaceae|g__Corynebacterium,k__Bacteria|k__Fusobacteriati|p__Fusobacteriota|c__Fusobacteriia|o__Fusobacteriales|f__Fusobacteriaceae|g__Fusobacterium,k__Bacteria|k__Pseudomonadati|p__Pseudomonadota|c__Betaproteobacteria|o__Neisseriales|f__Neisseriaceae|g__Kingella,k__Bacteria|k__Fusobacteriati|p__Fusobacteriota|c__Fusobacteriia|o__Fusobacteriales|f__Leptotrichiaceae|g__Leptotrichia,k__Bacteria|k__Bacillati|p__Actinomycetota|c__Coriobacteriia|o__Coriobacteriales|f__Atopobiaceae|g__Olsenella,k__Bacteria|k__Bacillati|p__Bacillota|c__Negativicutes|o__Selenomonadales|f__Selenomonadaceae|g__Selenomonas,k__Bacteria|k__Pseudomonadati|p__Bacteroidota|c__Bacteroidia|o__Bacteroidales|f__Tannerellaceae|g__Tannerella",2|3379134|1224|1236|135625|712|416916;2|1783272|201174|1760|85009|31957|2801844;2|3379134|29547|3031852|213849|72294|194;2|3379134|976|117743|200644|49546|1016;2|3379134|1224|1236|135615|868|2717;2|1783272|201174|1760|85007|1653|1716;2|3384189|32066|203490|203491|203492|848;2|3379134|1224|28216|206351|481|32257;2|3384189|32066|203490|203491|1129771|32067;2|1783272|201174|84998|84999|1643824|133925;2|1783272|1239|909932|909929|1843491|970;2|3379134|976|200643|171549|2005525|195950,Complete,NA
+bsdb:1086/10/1,Study 1086,case-control,38745393,10.1111/jcpe.13998,NA,"Bingöl M, Cardilli A, Bingöl AC, Löber U, Bang C, Franke A, Bartzela T, Beblo S, Mönch E, Stolz S, Schaefer AS, Forslund SK , Richter GM",Oral microbiota of patients with phenylketonuria: A nation-based cross-sectional study,Journal of clinical periodontology,2024,"16s rDNA sequencing, periodontitis, phenylketonuria, saliva, subgingival plaque",Experiment 10,Germany,Homo sapiens,Mouth,UBERON:0000165,Phenylketonuria,MONDO:0009861,Control Adults Saliva (Ctrl-Adults-S) patients,Control Adults Subgingival plaque (Ctrl-Adults-SP) patients,Healthy Control adults who stimulated Sub gingival plaque samples were gotten from,52,52,NA,16S,12,Illumina,Mann-Whitney (Wilcoxon),0.05,TRUE,NA,age,NA,NA,NA,NA,NA,NA,NA,Signature 1,Appendix Table 10,12 August 2024,MyleeeA,"MyleeeA,Tosin",Differential abundant genera in Control Adults Saliva (Ctrl-Adults-S) and Control Adults Subgingival plague (Ctrl-Adults-SP) patients,increased,"k__Bacteria|k__Pseudomonadati|p__Bacteroidota|c__Bacteroidia|o__Bacteroidales|f__Prevotellaceae|g__Alloprevotella,k__Bacteria|k__Bacillati|p__Actinomycetota|c__Coriobacteriia|o__Coriobacteriales|f__Atopobiaceae|g__Atopobium,k__Bacteria|k__Bacillati|p__Bacillota|c__Bacilli|o__Bacillales|f__Gemellaceae|g__Gemella,k__Bacteria|k__Pseudomonadati|p__Pseudomonadota|c__Gammaproteobacteria|o__Pasteurellales|f__Pasteurellaceae|g__Haemophilus,k__Bacteria|k__Pseudomonadati|p__Pseudomonadota|c__Betaproteobacteria|o__Neisseriales|f__Neisseriaceae|g__Neisseria,k__Bacteria|k__Bacillati|p__Bacillota|c__Clostridia|o__Lachnospirales|f__Lachnospiraceae|g__Oribacterium,k__Bacteria|k__Bacillati|p__Bacillota|c__Clostridia|o__Peptostreptococcales|f__Peptostreptococcaceae|g__Peptostreptococcus,k__Bacteria|k__Pseudomonadati|p__Bacteroidota|c__Bacteroidia|o__Bacteroidales|f__Porphyromonadaceae|g__Porphyromonas,k__Bacteria|k__Pseudomonadati|p__Bacteroidota|c__Bacteroidia|o__Bacteroidales|f__Prevotellaceae|g__Prevotella,k__Bacteria|k__Bacillati|p__Bacillota|c__Clostridia|o__Lachnospirales|f__Lachnospiraceae|g__Stomatobaculum,k__Bacteria|k__Bacillati|p__Bacillota|c__Bacilli|o__Lactobacillales|f__Streptococcaceae|g__Streptococcus,k__Bacteria|k__Bacillati|p__Bacillota|c__Negativicutes|o__Veillonellales|f__Veillonellaceae|g__Veillonella,k__Eukaryota|k__Viridiplantae|p__Streptophyta|c__Magnoliopsida|o__Fabales|f__Fabaceae|s__Papilionoideae|g__Rothia",2|3379134|976|200643|171549|171552|1283313;2|1783272|201174|84998|84999|1643824|1380;2|1783272|1239|91061|1385|539738|1378;2|3379134|1224|1236|135625|712|724;2|3379134|1224|28216|206351|481|482;2|1783272|1239|186801|3085636|186803|265975;2|1783272|1239|186801|3082720|186804|1257;2|3379134|976|200643|171549|171551|836;2|3379134|976|200643|171549|171552|838;2|1783272|1239|186801|3085636|186803|1213720;2|1783272|1239|91061|186826|1300|1301;2|1783272|1239|909932|1843489|31977|29465;2759|33090|35493|3398|72025|3803|3814|508215,Complete,NA
+bsdb:1086/10/2,Study 1086,case-control,38745393,10.1111/jcpe.13998,NA,"Bingöl M, Cardilli A, Bingöl AC, Löber U, Bang C, Franke A, Bartzela T, Beblo S, Mönch E, Stolz S, Schaefer AS, Forslund SK , Richter GM",Oral microbiota of patients with phenylketonuria: A nation-based cross-sectional study,Journal of clinical periodontology,2024,"16s rDNA sequencing, periodontitis, phenylketonuria, saliva, subgingival plaque",Experiment 10,Germany,Homo sapiens,Mouth,UBERON:0000165,Phenylketonuria,MONDO:0009861,Control Adults Saliva (Ctrl-Adults-S) patients,Control Adults Subgingival plaque (Ctrl-Adults-SP) patients,Healthy Control adults who stimulated Sub gingival plaque samples were gotten from,52,52,NA,16S,12,Illumina,Mann-Whitney (Wilcoxon),0.05,TRUE,NA,age,NA,NA,NA,NA,NA,NA,NA,Signature 2,Appendix Table 10,12 August 2024,MyleeeA,MyleeeA,Differential abundant genera in Control Saliva (Ctrl-S) and Control Subgingival plague (Ctrl-SP) patients.,decreased,"k__Bacteria|k__Pseudomonadati|p__Pseudomonadota|c__Gammaproteobacteria|o__Pasteurellales|f__Pasteurellaceae|g__Aggregatibacter,k__Bacteria|k__Bacillati|p__Actinomycetota|c__Actinomycetes|o__Propionibacteriales|f__Propionibacteriaceae|g__Arachnia,k__Bacteria|k__Pseudomonadati|p__Campylobacterota|c__Epsilonproteobacteria|o__Campylobacterales|f__Campylobacteraceae|g__Campylobacter,k__Bacteria|k__Pseudomonadati|p__Bacteroidota|c__Flavobacteriia|o__Flavobacteriales|f__Flavobacteriaceae|g__Capnocytophaga,k__Bacteria|k__Pseudomonadati|p__Pseudomonadota|c__Gammaproteobacteria|o__Cardiobacteriales|f__Cardiobacteriaceae|g__Cardiobacterium,k__Bacteria|k__Bacillati|p__Actinomycetota|c__Actinomycetes|o__Mycobacteriales|f__Corynebacteriaceae|g__Corynebacterium,k__Bacteria|k__Fusobacteriati|p__Fusobacteriota|c__Fusobacteriia|o__Fusobacteriales|f__Fusobacteriaceae|g__Fusobacterium,k__Bacteria|k__Pseudomonadati|p__Pseudomonadota|c__Betaproteobacteria|o__Neisseriales|f__Neisseriaceae|g__Kingella,k__Bacteria|k__Bacillati|p__Actinomycetota|c__Coriobacteriia|o__Coriobacteriales|f__Atopobiaceae|g__Olsenella,k__Bacteria|k__Bacillati|p__Bacillota|c__Negativicutes|o__Selenomonadales|f__Selenomonadaceae|g__Selenomonas,k__Bacteria|k__Pseudomonadati|p__Bacteroidota|c__Bacteroidia|o__Bacteroidales|f__Tannerellaceae|g__Tannerella",2|3379134|1224|1236|135625|712|416916;2|1783272|201174|1760|85009|31957|2801844;2|3379134|29547|3031852|213849|72294|194;2|3379134|976|117743|200644|49546|1016;2|3379134|1224|1236|135615|868|2717;2|1783272|201174|1760|85007|1653|1716;2|3384189|32066|203490|203491|203492|848;2|3379134|1224|28216|206351|481|32257;2|1783272|201174|84998|84999|1643824|133925;2|1783272|1239|909932|909929|1843491|970;2|3379134|976|200643|171549|2005525|195950,Complete,NA
 bsdb:1086/11/1,Study 1086,case-control,38745393,10.1111/jcpe.13998,NA,"Bingöl M, Cardilli A, Bingöl AC, Löber U, Bang C, Franke A, Bartzela T, Beblo S, Mönch E, Stolz S, Schaefer AS, Forslund SK , Richter GM",Oral microbiota of patients with phenylketonuria: A nation-based cross-sectional study,Journal of clinical periodontology,2024,"16s rDNA sequencing, periodontitis, phenylketonuria, saliva, subgingival plaque",Experiment 11,Germany,Homo sapiens,Mouth,UBERON:0000165,Phenylketonuria,MONDO:0009861,Control Children (CTRL Ch-S),Control Children (CTRL Ch-SP),Healthy Control Children without PKU who stimulated Sub gingival plaque samples were gotten from.,62,61,NA,16S,12,Illumina,Mann-Whitney (Wilcoxon),0.05,TRUE,NA,age,NA,NA,NA,NA,NA,NA,NA,Signature 1,Figure 2(D),12 August 2024,MyleeeA,MyleeeA,Differential abundant genera in Control Saliva and Control Subgingival plague Children samples,increased,"k__Bacteria|p__Bacteroidota|c__Bacteroidia|o__Bacteroidales|f__Prevotellaceae|g__Prevotella,k__Bacteria|p__Bacillota|c__Clostridia|o__Lachnospirales|f__Lachnospiraceae|g__Oribacterium,k__Bacteria|p__Bacteroidota|c__Bacteroidia|o__Bacteroidales|f__Porphyromonadaceae|g__Porphyromonas,k__Bacteria|p__Pseudomonadota|c__Betaproteobacteria|o__Neisseriales|f__Neisseriaceae|g__Neisseria,k__Bacteria|p__Bacteroidota|c__Bacteroidia|o__Bacteroidales|f__Prevotellaceae|g__Alloprevotella,k__Bacteria|p__Actinomycetota|c__Coriobacteriia|o__Coriobacteriales|f__Atopobiaceae|g__Atopobium,k__Bacteria|p__Bacillota|c__Bacilli|o__Bacillales|f__Gemellaceae|g__Gemella,k__Bacteria|p__Pseudomonadota|c__Gammaproteobacteria|o__Pasteurellales|f__Pasteurellaceae|g__Haemophilus,k__Bacteria|p__Bacillota|c__Clostridia|o__Peptostreptococcales|f__Peptostreptococcaceae|g__Peptostreptococcus,k__Bacteria|p__Bacillota|c__Clostridia|o__Lachnospirales|f__Lachnospiraceae|g__Stomatobaculum,k__Bacteria|p__Bacillota|c__Bacilli|o__Lactobacillales|f__Streptococcaceae|g__Streptococcus,k__Bacteria|p__Bacillota|c__Negativicutes|o__Veillonellales|f__Veillonellaceae|g__Veillonella",2|976|200643|171549|171552|838;2|1239|186801|3085636|186803|265975;2|976|200643|171549|171551|836;2|1224|28216|206351|481|482;2|976|200643|171549|171552|1283313;2|201174|84998|84999|1643824|1380;2|1239|91061|1385|539738|1378;2|1224|1236|135625|712|724;2|1239|186801|3082720|186804|1257;2|1239|186801|3085636|186803|1213720;2|1239|91061|186826|1300|1301;2|1239|909932|1843489|31977|29465,Complete,NA
 bsdb:1086/11/2,Study 1086,case-control,38745393,10.1111/jcpe.13998,NA,"Bingöl M, Cardilli A, Bingöl AC, Löber U, Bang C, Franke A, Bartzela T, Beblo S, Mönch E, Stolz S, Schaefer AS, Forslund SK , Richter GM",Oral microbiota of patients with phenylketonuria: A nation-based cross-sectional study,Journal of clinical periodontology,2024,"16s rDNA sequencing, periodontitis, phenylketonuria, saliva, subgingival plaque",Experiment 11,Germany,Homo sapiens,Mouth,UBERON:0000165,Phenylketonuria,MONDO:0009861,Control Children (CTRL Ch-S),Control Children (CTRL Ch-SP),Healthy Control Children without PKU who stimulated Sub gingival plaque samples were gotten from.,62,61,NA,16S,12,Illumina,Mann-Whitney (Wilcoxon),0.05,TRUE,NA,age,NA,NA,NA,NA,NA,NA,NA,Signature 2,Figure 2(D),12 August 2024,MyleeeA,MyleeeA,Differential abundant genera in Control Saliva and Control Subgingival plague Children samples,decreased,"k__Bacteria|p__Bacteroidota|c__Flavobacteriia|o__Flavobacteriales|f__Flavobacteriaceae|g__Capnocytophaga,k__Bacteria|p__Fusobacteriota|c__Fusobacteriia|o__Fusobacteriales|f__Fusobacteriaceae|g__Fusobacterium,k__Bacteria|p__Actinomycetota|c__Actinomycetes|o__Mycobacteriales|f__Corynebacteriaceae|g__Corynebacterium,k__Bacteria|p__Pseudomonadota|c__Betaproteobacteria|o__Neisseriales|f__Neisseriaceae|g__Kingella,k__Bacteria|p__Actinomycetota|c__Actinomycetes|o__Propionibacteriales|f__Propionibacteriaceae|g__Arachnia,k__Bacteria|p__Pseudomonadota|c__Gammaproteobacteria|o__Cardiobacteriales|f__Cardiobacteriaceae|g__Cardiobacterium,k__Bacteria|p__Actinomycetota|c__Coriobacteriia|o__Coriobacteriales|f__Atopobiaceae|g__Olsenella,k__Bacteria|p__Bacteroidota|c__Bacteroidia|o__Bacteroidales|f__Tannerellaceae|g__Tannerella,k__Bacteria|p__Campylobacterota|c__Epsilonproteobacteria|o__Campylobacterales|f__Campylobacteraceae|g__Campylobacter,k__Bacteria|p__Synergistota|c__Synergistia|o__Synergistales|f__Aminobacteriaceae|g__Fretibacterium",2|976|117743|200644|49546|1016;2|32066|203490|203491|203492|848;2|201174|1760|85007|1653|1716;2|1224|28216|206351|481|32257;2|201174|1760|85009|31957|2801844;2|1224|1236|135615|868|2717;2|201174|84998|84999|1643824|133925;2|976|200643|171549|2005525|195950;2|29547|3031852|213849|72294|194;2|508458|649775|649776|3029087|1434006,Complete,NA
 bsdb:1086/12/1,Study 1086,case-control,38745393,10.1111/jcpe.13998,NA,"Bingöl M, Cardilli A, Bingöl AC, Löber U, Bang C, Franke A, Bartzela T, Beblo S, Mönch E, Stolz S, Schaefer AS, Forslund SK , Richter GM",Oral microbiota of patients with phenylketonuria: A nation-based cross-sectional study,Journal of clinical periodontology,2024,"16s rDNA sequencing, periodontitis, phenylketonuria, saliva, subgingival plaque",Experiment 12,Germany,Homo sapiens,Mouth,UBERON:0000165,Phenylketonuria,MONDO:0009861,Phenylketonuria (PKU-S),Phenylketonuria (PKU-SP),Patients diagnosed with Phenylketonuria (PKU) and who stimulated Sub gingival plaque samples were gotten from.,109,96,NA,16S,12,Illumina,Mann-Whitney (Wilcoxon),0.05,TRUE,NA,age,NA,NA,NA,NA,NA,NA,NA,Signature 1,Figure 2(D),12 August 2024,MyleeeA,MyleeeA,Differential abundant genera in PKU Saliva and PKU Subgingival plague Patient samples,increased,"k__Bacteria|p__Bacteroidota|c__Bacteroidia|o__Bacteroidales|f__Prevotellaceae|g__Alloprevotella,k__Bacteria|p__Actinomycetota|c__Coriobacteriia|o__Coriobacteriales|f__Atopobiaceae|g__Atopobium,k__Bacteria|p__Bacillota|c__Bacilli|o__Bacillales|f__Gemellaceae|g__Gemella,k__Bacteria|p__Pseudomonadota|c__Gammaproteobacteria|o__Pasteurellales|f__Pasteurellaceae|g__Haemophilus,k__Bacteria|p__Bacillota|c__Clostridia|o__Lachnospirales|f__Lachnospiraceae|g__Lachnoanaerobaculum,k__Bacteria|p__Pseudomonadota|c__Betaproteobacteria|o__Neisseriales|f__Neisseriaceae|g__Neisseria,k__Bacteria|p__Bacillota|c__Clostridia|o__Lachnospirales|f__Lachnospiraceae|g__Oribacterium,k__Bacteria|p__Bacillota|c__Clostridia|o__Peptostreptococcales|f__Peptostreptococcaceae|g__Peptostreptococcus,k__Bacteria|p__Bacteroidota|c__Bacteroidia|o__Bacteroidales|f__Porphyromonadaceae|g__Porphyromonas,k__Bacteria|p__Bacteroidota|c__Bacteroidia|o__Bacteroidales|f__Prevotellaceae|g__Prevotella,k__Eukaryota|k__Viridiplantae|p__Streptophyta|c__Magnoliopsida|o__Fabales|f__Fabaceae|s__Papilionoideae|g__Rothia,k__Bacteria|p__Bacillota|c__Clostridia|o__Lachnospirales|f__Lachnospiraceae|g__Stomatobaculum,k__Bacteria|p__Bacillota|c__Bacilli|o__Lactobacillales|f__Streptococcaceae|g__Streptococcus,k__Bacteria|p__Bacillota|c__Negativicutes|o__Veillonellales|f__Veillonellaceae|g__Veillonella",2|976|200643|171549|171552|1283313;2|201174|84998|84999|1643824|1380;2|1239|91061|1385|539738|1378;2|1224|1236|135625|712|724;2|1239|186801|3085636|186803|1164882;2|1224|28216|206351|481|482;2|1239|186801|3085636|186803|265975;2|1239|186801|3082720|186804|1257;2|976|200643|171549|171551|836;2|976|200643|171549|171552|838;2759|33090|35493|3398|72025|3803|3814|508215;2|1239|186801|3085636|186803|1213720;2|1239|91061|186826|1300|1301;2|1239|909932|1843489|31977|29465,Complete,NA
@@ -6572,9 +6572,9 @@ bsdb:1163/1/2,Study 1163,"cross-sectional observational, not case-control",28362
 bsdb:1163/2/1,Study 1163,"cross-sectional observational, not case-control",28362071,https://doi.org/10.7448/IAS.20.1.21526,NA,"Villanueva-Millán MJ, Pérez-Matute P, Recio-Fernández E, Lezana Rosales JM , Oteo JA",Differential effects of antiretrovirals on microbial translocation and gut microbiota composition of HIV-infected patients,Journal of the International AIDS Society,2017,"HIV infection, antiretroviral therapy, bacterial diversity, gut microbiota, inflammation, microbial translocation",Experiment 2,Spain,Homo sapiens,Feces,UBERON:0001988,HIV infection,EFO:0000764,non-infected volunteers (Control),HIV-positive (cART),This group includes HIV-infected patients on cART (HIV+(cART)) for at least one year and with viral load of <20 cop/mL.,21,45,3 months,16S,4,Illumina,Kruskall-Wallis,0.05,TRUE,NA,"age,body mass index,sex",NA,NA,increased,increased,NA,NA,increased,Signature 1,Table 2,9 January 2025,Joiejoie,Joiejoie,Relative abundance of major phyla present in the gut in HIV-positive (cART).,increased,k__Bacteria|k__Pseudomonadati|p__Pseudomonadota,2|3379134|1224,Complete,NA
 bsdb:1163/2/2,Study 1163,"cross-sectional observational, not case-control",28362071,https://doi.org/10.7448/IAS.20.1.21526,NA,"Villanueva-Millán MJ, Pérez-Matute P, Recio-Fernández E, Lezana Rosales JM , Oteo JA",Differential effects of antiretrovirals on microbial translocation and gut microbiota composition of HIV-infected patients,Journal of the International AIDS Society,2017,"HIV infection, antiretroviral therapy, bacterial diversity, gut microbiota, inflammation, microbial translocation",Experiment 2,Spain,Homo sapiens,Feces,UBERON:0001988,HIV infection,EFO:0000764,non-infected volunteers (Control),HIV-positive (cART),This group includes HIV-infected patients on cART (HIV+(cART)) for at least one year and with viral load of <20 cop/mL.,21,45,3 months,16S,4,Illumina,Kruskall-Wallis,0.05,TRUE,NA,"age,body mass index,sex",NA,NA,increased,increased,NA,NA,increased,Signature 2,Table 2,9 January 2025,Joiejoie,Joiejoie,Relative abundance of major phyla present in the gut in HIV-positive (cART).,decreased,k__Bacteria|k__Bacillati|p__Bacillota,2|1783272|1239,Complete,NA
 bsdb:1163/3/1,Study 1163,"cross-sectional observational, not case-control",28362071,https://doi.org/10.7448/IAS.20.1.21526,NA,"Villanueva-Millán MJ, Pérez-Matute P, Recio-Fernández E, Lezana Rosales JM , Oteo JA",Differential effects of antiretrovirals on microbial translocation and gut microbiota composition of HIV-infected patients,Journal of the International AIDS Society,2017,"HIV infection, antiretroviral therapy, bacterial diversity, gut microbiota, inflammation, microbial translocation",Experiment 3,Spain,Homo sapiens,Feces,UBERON:0001988,HIV infection,EFO:0000764,non-infected volunteers (Control),NRTIs + PIs,This group includes patients on family treatment of nucleoside reverse transcriptase inhibitors (NRTIs) and protease inhibitors (PIs),21,15,3 months,16S,4,Illumina,Kruskall-Wallis,0.05,TRUE,NA,"age,body mass index,sex",NA,NA,decreased,decreased,NA,NA,decreased,Signature 1,Table 2,9 January 2025,Joiejoie,Joiejoie,Relative abundance of major phyla present in the gut in NRTIs + PIs.,increased,k__Bacteria|k__Bacillati|p__Actinomycetota,2|1783272|201174,Complete,NA
-bsdb:1163/3/2,Study 1163,"cross-sectional observational, not case-control",28362071,https://doi.org/10.7448/IAS.20.1.21526,NA,"Villanueva-Millán MJ, Pérez-Matute P, Recio-Fernández E, Lezana Rosales JM , Oteo JA",Differential effects of antiretrovirals on microbial translocation and gut microbiota composition of HIV-infected patients,Journal of the International AIDS Society,2017,"HIV infection, antiretroviral therapy, bacterial diversity, gut microbiota, inflammation, microbial translocation",Experiment 3,Spain,Homo sapiens,Feces,UBERON:0001988,HIV infection,EFO:0000764,non-infected volunteers (Control),NRTIs + PIs,This group includes patients on family treatment of nucleoside reverse transcriptase inhibitors (NRTIs) and protease inhibitors (PIs),21,15,3 months,16S,4,Illumina,Kruskall-Wallis,0.05,TRUE,NA,"age,body mass index,sex",NA,NA,decreased,decreased,NA,NA,decreased,Signature 2,Table 2,9 January 2025,NA,NA,Relative abundance of major phyla present in the gut in NRTIs + PIs.,decreased,NA,NA,Complete,NA
-bsdb:1163/4/1,Study 1163,"cross-sectional observational, not case-control",28362071,https://doi.org/10.7448/IAS.20.1.21526,NA,"Villanueva-Millán MJ, Pérez-Matute P, Recio-Fernández E, Lezana Rosales JM , Oteo JA",Differential effects of antiretrovirals on microbial translocation and gut microbiota composition of HIV-infected patients,Journal of the International AIDS Society,2017,"HIV infection, antiretroviral therapy, bacterial diversity, gut microbiota, inflammation, microbial translocation",Experiment 4,Spain,Homo sapiens,Feces,UBERON:0001988,HIV infection,EFO:0000764,non-infected volunteers (C0ntrol),NRTIs + NNRTIs,This group includes patients on family treatment of nucleoside reverse transcriptase inhibitors (NRTIs) and non-nucleoside reverse transcriptase inhibitors (NNRTIs),21,22,3 months,16S,4,Illumina,Kruskall-Wallis,0.05,TRUE,NA,"age,body mass index,sex",NA,NA,increased,increased,NA,NA,increased,Signature 1,Table 2,9 January 2025,NA,NA,Relative abundance of major phyla present in the gut in NRTIs + NNRTIs.,increased,NA,NA,Complete,NA
-bsdb:1163/4/2,Study 1163,"cross-sectional observational, not case-control",28362071,https://doi.org/10.7448/IAS.20.1.21526,NA,"Villanueva-Millán MJ, Pérez-Matute P, Recio-Fernández E, Lezana Rosales JM , Oteo JA",Differential effects of antiretrovirals on microbial translocation and gut microbiota composition of HIV-infected patients,Journal of the International AIDS Society,2017,"HIV infection, antiretroviral therapy, bacterial diversity, gut microbiota, inflammation, microbial translocation",Experiment 4,Spain,Homo sapiens,Feces,UBERON:0001988,HIV infection,EFO:0000764,non-infected volunteers (C0ntrol),NRTIs + NNRTIs,This group includes patients on family treatment of nucleoside reverse transcriptase inhibitors (NRTIs) and non-nucleoside reverse transcriptase inhibitors (NNRTIs),21,22,3 months,16S,4,Illumina,Kruskall-Wallis,0.05,TRUE,NA,"age,body mass index,sex",NA,NA,increased,increased,NA,NA,increased,Signature 2,Table 2,9 January 2025,NA,NA,Relative abundance of major phyla present in the gut in NRTIs + NNRTIs.,decreased,NA,NA,Complete,NA
+bsdb:1163/3/2,Study 1163,"cross-sectional observational, not case-control",28362071,https://doi.org/10.7448/IAS.20.1.21526,NA,"Villanueva-Millán MJ, Pérez-Matute P, Recio-Fernández E, Lezana Rosales JM , Oteo JA",Differential effects of antiretrovirals on microbial translocation and gut microbiota composition of HIV-infected patients,Journal of the International AIDS Society,2017,"HIV infection, antiretroviral therapy, bacterial diversity, gut microbiota, inflammation, microbial translocation",Experiment 3,Spain,Homo sapiens,Feces,UBERON:0001988,HIV infection,EFO:0000764,non-infected volunteers (Control),NRTIs + PIs,This group includes patients on family treatment of nucleoside reverse transcriptase inhibitors (NRTIs) and protease inhibitors (PIs),21,15,3 months,16S,4,Illumina,Kruskall-Wallis,0.05,TRUE,NA,"age,body mass index,sex",NA,NA,decreased,decreased,NA,NA,decreased,Signature 2,Table 2,9 January 2025,Joiejoie,Joiejoie,Relative abundance of major phyla present in the gut in NRTIs + PIs.,decreased,k__Bacteria|k__Bacillati|p__Bacillota,2|1783272|1239,Complete,NA
+bsdb:1163/4/1,Study 1163,"cross-sectional observational, not case-control",28362071,https://doi.org/10.7448/IAS.20.1.21526,NA,"Villanueva-Millán MJ, Pérez-Matute P, Recio-Fernández E, Lezana Rosales JM , Oteo JA",Differential effects of antiretrovirals on microbial translocation and gut microbiota composition of HIV-infected patients,Journal of the International AIDS Society,2017,"HIV infection, antiretroviral therapy, bacterial diversity, gut microbiota, inflammation, microbial translocation",Experiment 4,Spain,Homo sapiens,Feces,UBERON:0001988,HIV infection,EFO:0000764,non-infected volunteers (C0ntrol),NRTIs + NNRTIs,This group includes patients on family treatment of nucleoside reverse transcriptase inhibitors (NRTIs) and non-nucleoside reverse transcriptase inhibitors (NNRTIs),21,22,3 months,16S,4,Illumina,Kruskall-Wallis,0.05,TRUE,NA,"age,body mass index,sex",NA,NA,increased,increased,NA,NA,increased,Signature 1,Table 2,9 January 2025,Joiejoie,Joiejoie,Relative abundance of major phyla present in the gut in NRTIs + NNRTIs.,increased,k__Bacteria|k__Pseudomonadati|p__Pseudomonadota,2|3379134|1224,Complete,NA
+bsdb:1163/4/2,Study 1163,"cross-sectional observational, not case-control",28362071,https://doi.org/10.7448/IAS.20.1.21526,NA,"Villanueva-Millán MJ, Pérez-Matute P, Recio-Fernández E, Lezana Rosales JM , Oteo JA",Differential effects of antiretrovirals on microbial translocation and gut microbiota composition of HIV-infected patients,Journal of the International AIDS Society,2017,"HIV infection, antiretroviral therapy, bacterial diversity, gut microbiota, inflammation, microbial translocation",Experiment 4,Spain,Homo sapiens,Feces,UBERON:0001988,HIV infection,EFO:0000764,non-infected volunteers (C0ntrol),NRTIs + NNRTIs,This group includes patients on family treatment of nucleoside reverse transcriptase inhibitors (NRTIs) and non-nucleoside reverse transcriptase inhibitors (NNRTIs),21,22,3 months,16S,4,Illumina,Kruskall-Wallis,0.05,TRUE,NA,"age,body mass index,sex",NA,NA,increased,increased,NA,NA,increased,Signature 2,Table 2,9 January 2025,Joiejoie,Joiejoie,Relative abundance of major phyla present in the gut in NRTIs + NNRTIs.,decreased,NA,NA,Complete,NA
 bsdb:1163/5/1,Study 1163,"cross-sectional observational, not case-control",28362071,https://doi.org/10.7448/IAS.20.1.21526,NA,"Villanueva-Millán MJ, Pérez-Matute P, Recio-Fernández E, Lezana Rosales JM , Oteo JA",Differential effects of antiretrovirals on microbial translocation and gut microbiota composition of HIV-infected patients,Journal of the International AIDS Society,2017,"HIV infection, antiretroviral therapy, bacterial diversity, gut microbiota, inflammation, microbial translocation",Experiment 5,Spain,Homo sapiens,Feces,UBERON:0001988,HIV infection,EFO:0000764,Non-infected volunteers (Control),NRTIs + INSTIs,This group includes patients on family treatment of nucleoside reverse transcriptase inhibitors (NRTIs) with integrase strand transfer inhibitors (INSTIs),21,8,3 months,16S,4,Illumina,Kruskall-Wallis,0.05,TRUE,NA,"age,body mass index,sex",NA,NA,increased,increased,NA,NA,increased,Signature 1,Table 2,9 January 2025,NA,NA,Relative abundance of major phyla present in the gut in NRTIs + INSTIs.,increased,NA,NA,Complete,NA
 bsdb:1163/5/2,Study 1163,"cross-sectional observational, not case-control",28362071,https://doi.org/10.7448/IAS.20.1.21526,NA,"Villanueva-Millán MJ, Pérez-Matute P, Recio-Fernández E, Lezana Rosales JM , Oteo JA",Differential effects of antiretrovirals on microbial translocation and gut microbiota composition of HIV-infected patients,Journal of the International AIDS Society,2017,"HIV infection, antiretroviral therapy, bacterial diversity, gut microbiota, inflammation, microbial translocation",Experiment 5,Spain,Homo sapiens,Feces,UBERON:0001988,HIV infection,EFO:0000764,Non-infected volunteers (Control),NRTIs + INSTIs,This group includes patients on family treatment of nucleoside reverse transcriptase inhibitors (NRTIs) with integrase strand transfer inhibitors (INSTIs),21,8,3 months,16S,4,Illumina,Kruskall-Wallis,0.05,TRUE,NA,"age,body mass index,sex",NA,NA,increased,increased,NA,NA,increased,Signature 2,Table 2,9 January 2025,NA,NA,Relative abundance of major phyla present in the gut in NRTIs + INSTIs.,decreased,NA,NA,Complete,NA
 bsdb:1163/6/1,Study 1163,"cross-sectional observational, not case-control",28362071,https://doi.org/10.7448/IAS.20.1.21526,NA,"Villanueva-Millán MJ, Pérez-Matute P, Recio-Fernández E, Lezana Rosales JM , Oteo JA",Differential effects of antiretrovirals on microbial translocation and gut microbiota composition of HIV-infected patients,Journal of the International AIDS Society,2017,"HIV infection, antiretroviral therapy, bacterial diversity, gut microbiota, inflammation, microbial translocation",Experiment 6,Spain,Homo sapiens,Feces,UBERON:0001988,HIV infection,EFO:0000764,non-infected volunteers (Control),NRTIs+PIs,This group includes patients on family treatment of nucleoside reverse transcriptase inhibitors (NRTIs) and protease inhibitors (PIs),21,15,3 months,16S,4,Illumina,Mann-Whitney (Wilcoxon),0.05,TRUE,NA,"age,body mass index,sex",NA,NA,decreased,decreased,NA,NA,decreased,Signature 1,Table 3,9 January 2025,NA,NA,"Combined antiretroviral therapy modified the relative abundance of taxonomical groups (order, family, genus, species) in NRTIs+PIs",increased,"k__Bacteria|k__Bacillati|p__Bacillota|c__Clostridia|o__Eubacteriales|s__Clostridiales bacterium,k__Bacteria|k__Bacillati|p__Bacillota|c__Clostridia|o__Lachnospirales|f__Lachnospiraceae,k__Bacteria|k__Bacillati|p__Actinomycetota|c__Coriobacteriia|o__Eggerthellales|f__Eggerthellaceae|g__Eggerthella,k__Bacteria|k__Bacillati|p__Bacillota|c__Clostridia|o__Eubacteriales|f__Oscillospiraceae|g__Flavonifractor|s__Flavonifractor plautii",2|1783272|1239|186801|186802|1898207;2|1783272|1239|186801|3085636|186803;2|1783272|201174|84998|1643822|1643826|84111;2|1783272|1239|186801|186802|216572|946234|292800,Complete,NA