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antiSMASH - the antibiotics and Secondary Metabolite Analysis SHell

This repository is used to port antiSMASH to be compatible with Python 3, along with mayor restructuring and code cleanup efforts. It is not feature-compatible with previous antiSMASH versions for now, and certainly is not production-quality code.

Development & Funding

The development of antiSMASH was started as a collaboration of the Department of Microbial Physiology and Groningen Bioinformatics Centre of the University of Groningen, the Department of Microbiology of the University of Tübingen, and the Department of Bioengineering and Therapeutic Sciences at the University of California, San Francisco. With the move of the PIs and developers, development continues now at the Manchester Institute of Biotechnology, the Bioinformatics Group at Wageningen University and The Novo Nordisk Foundation Center for Biosustainability in Lyngby.

antiSMASH development was/is supported by the GenBiotics program of the Dutch Technology Foundation (STW), which is the applied-science division of The Netherlands Organisation for Scientific Research (NWO) and the Technology Programme of the Ministry of Economic Affairs (grant STW 10463), GenBioCom program of the German Ministry of Education and Research (BMBF) grant 0315585A, the German Center for Infection Research (DZIF) and the Novo Nordisk Foundation.

Publications

See http://antismash.secondarymetabolites.org/#!/about for information on citing antiSMASH.

Installation

There are multiple options on how to get your own copy of antiSMASH up and running. See our install documentation for detailed information.

License

antiSMASH is an open source tool available under the GNU Affero General Public License version 3.0 or greater. See the LICENSE.txt file for details.

Acknowledgements

Some icons used courtesy of fontawesome.com


Instructions for cluster splitting functionality

If the genes flanking a cluster are known, this fork of antiSMASH is able to set the boundaries of this cluster directly at the flanking genes. This automates manual cluster trimming based on known boundary genes. It does not function when boundary genes are not known. Amino acid sequences of flanking genes at which to split a cluster need to be supplied in FASTA format, and copied into the antismash/detection/dmz_cds/data directory.

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antiSMASH with manual cluster splitting

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