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varGWAS: GWAS of SNP variance effects

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Software to perform genome-wide association study of SNP effects on trait variance

Documentation

Full documentation available from https://mrcieu.github.io/varGWAS

R

R-package also available from https://github.com/MRCIEU/varGWASR

Citation

Lyon M, Millard L, Davey Smith G, Gaunt T, Tilling K. Hypothesis-free detection of gene-interaction effects on biomarker concentration in UK Biobank using variance prioritisation. MedRxiv (2022). https://doi.org/10.1101/2022.01.05.21268406

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GWAS of trait variance (C++)

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  • R 56.4%
  • C++ 40.3%
  • CMake 2.0%
  • Other 1.3%