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update readthedocs documentations
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mehrdadbakhtiari committed Mar 24, 2019
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6 changes: 4 additions & 2 deletions docs/installation.rst
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Expand Up @@ -23,9 +23,11 @@ adVNTR could be invoked from command line with ``advntr``

Data Requirements
-----------------
In order to genotype VNTRs, you need to either train models for loci of interest or use pre-trained models (recommended):
* To run adVNTR on trained VNTR models:
- Download `vntr_data.zip <https://cseweb.ucsd.edu/~mbakhtia/adVNTR/vntr_data.zip>`_ and extract it inside the project directory.
Alternatively, you can add model for custom VNTR. See :ref:`add-custom-vntr-label` for more information.
- Download `vntr_data_recommended_loci.zip <https://cseweb.ucsd.edu/~mbakhtia/adVNTR/vntr_data_recommended_loci.zip>`_ and extract it inside the project directory. This includes a set of pre-trained VNTR models for Illumina (6719 loci) and Pacbio (8960 loci) sequencing data.
- You can also download and use `vntr_data_genic_loci.zip <https://cseweb.ucsd.edu/~mbakhtia/adVNTR/vntr_data_genic_loci.zip>`_ for 158522 VNTRs that results in having much longer running time.
Alternatively, you can add model for custom VNTR. See :ref:`add-custom-vntr-label` for more information about training models for custom VNTRs.

Execution:
----------
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10 changes: 5 additions & 5 deletions docs/quickstart.rst
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Expand Up @@ -21,9 +21,9 @@ To install adVNTR, run these commands:
Genotype Predefined VNTR in Simulated Data
------------------------------------------
To genotype a VNTR in the simulated dataset, one option is to use predefined models.
Download `vntr_data.zip <https://cseweb.ucsd.edu/~mbakhtia/adVNTR/vntr_data.zip>`_ and extract it inside the
project directory to use these models from human genome. Here, we genotype a VNTR with id 301645 that corresponds to a
disease-linked VNTR. The list of some known VNTRs and their ID is available at
Download `vntr_data_recommended_loci.zip <https://cseweb.ucsd.edu/~mbakhtia/adVNTR/vntr_data_recommended_loci.zip>`_ and
extract it inside the project directory to use these models from human genome. Here, we genotype a VNTR with id 301645
that corresponds to a disease-linked VNTR. The list of some known VNTRs and their ID is available at
`Disease-linked-VNTRs page <https://github.com/mehrdadbakhtiari/adVNTR/wiki/Disease-linked-VNTRs>`_ in wiki.

Then, download `simulated sequencing data of a human sample <https://cseweb.ucsd.edu/~mbakhtia/adVNTR/quickstart/>`_.
Expand All @@ -37,8 +37,8 @@ Run this command to get 2/5 genotype for this VNTR.
Genotype Custom VNTR
--------------------
You can train a new model for a VNTR that doesn't exist in predefined models. Instead of downloading
`vntr_data.zip <https://cseweb.ucsd.edu/~mbakhtia/adVNTR/vntr_data.zip>`_, you need the organism (here, human) reference
genome to train a model for a specific VNTR.
`vntr_data_recommended_loci.zip <https://cseweb.ucsd.edu/~mbakhtia/adVNTR/vntr_data_recommended_loci.zip>`_, you need
the organism (here, human) reference genome to train a model for a specific VNTR.
`Download chromosome 21 of hg19 <http://hgdownload.cse.ucsc.edu/goldenPath/hg19/chromosomes/chr21.fa.gz>`_ and extract it.
It is recommended to have full reference genome of the organism to add the model, however, we use a single chromosome
in quickstart since it is easier to download and runs faster.
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