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docs: api: reduce methods text, esp. duplicated in appendix
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jessexknight committed Nov 16, 2021
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5 changes: 4 additions & 1 deletion docs/api/app.search.tex
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\section{Search Strategy}
\label{a:search}
We designed our search strategy with guidance from
an information specialist at our affiliate library.
an information specialist at our affiliate library (KF).
% ==============================================================================
\subsection{Search Terms}
\label{aa:search:terms}
Expand All @@ -10,6 +10,9 @@ \subsection{Search Terms}
\st{.mp} searches the main text fields, including
title, abstract, and heading words.
We searched MEDLINE and EMBASE via Ovid on 2020 March 20.
Duplicate studies were removed automatically by Ovid and by Covidence;
four additional duplicates with subtly different titles
were later identified and removed manually.
\input{tab/search}
% ==============================================================================
\subsection{Inclusion/Exclusion Criteria}
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55 changes: 14 additions & 41 deletions docs/api/methods.tex
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Expand Up @@ -2,20 +2,13 @@ \section{Methods}
\label{s:meth}
We conducted a scoping review according to the PRISMA extension for scoping reviews
(Appendix~\ref{a:prisma}).
First, we developed a conceptual framework to organize
assumptions and representations of risk heterogeneity
in compartmental HIV transmission models.
Then, we designed and implemented the search strategy,
and extracted data relevant to the framework to address our objectives.
% ==============================================================================
\subsection{Conceptual Framework for Risk Heterogeneity}
\label{ss:meth:framework}
We conceptualized ``factors of risk heterogeneity'', meaning
epidemiological stratifications and phenomena which may/not be included in transmission models.
Such factors could include if/how populations, rates, and probabilities
are stratified along various dimensions.
We defined the following 4 domains in which
these factors might influence the transmission impact of ART.
We defined ``factors of risk heterogeneity'' as
epidemiological phenomena and stratifications of populations, rates, or probabilities
which may/not be included in transmission models.
We defined 4 domains in which such factors might influence the transmission impact of ART:
\begin{itemize}
\item \textbf{Biological Effects:}
differential transmission risk within HIV disease course
Expand Down Expand Up @@ -50,41 +43,21 @@ \subsection{Search}
We searched MEDLINE and EMBASE via Ovid
using search terms related to Sub-Saharan Africa (SSA), HIV, and transmission modelling
(Table~\ref{tab:search}).
Search results were imported into Covidence \cite{Covidence} for screening.
Duplicate studies were removed automatically by Ovid and by Covidence;
four additional duplicates with subtly different titles were later identified and removed manually.
Potentially relevant studies were identified by title and abstract screening, followed
by full-text screening using the inclusion/exclusion criteria below.
Search results were de-duplicated and screened by title and abstract in Covidence \cite{Covidence},
followed by full-text screening using the criteria below.
One reviewer (JK) conducted the search, screening, and data extraction.
% ------------------------------------------------------------------------------
\subsubsection{Inclusion/Exclusion Criteria}
\label{sss:meth:criteria}
We included peer-reviewed, primarily modelling studies that used non-linear models of sexual HIV transmission
See Table~\ref{tab:criteria} for complete inclusion/exclusion criteria and definitions.
We included peer-reviewed, primary modelling studies that used
non-linear compartmental models of sexual HIV transmission
to project the prevention impacts of ART in any setting within SSA.
See Table~\ref{tab:criteria} for complete inclusion/exclusion criteria.
We only included studies published in English anytime before Jan~1, 2020.
We excluded conference publications, and those without primary modelling results and description of the methods,
such as commentaries and reviews.
If a model's details were provided in another peer-reviewed publication,
we extracted data from both publications as required.
\par
Inclusion criteria were as follows:
1) Used a non-linear compartmental model of sexual HIV transmission at the population level.
We defined \emph{non-linear models} as those where
future projected infections are a function of previously projected infections,
and \emph{compartmental models} as those where
system variables represent the numbers of individuals in each state,
rather than unique individuals \cite{Garnett2011}.
Thus, statistical models, models without dynamic transmission, and individual-based models were excluded.
2) The model was parameterized/calibrated to reflect at least one setting within SSA
(see Appendix~\ref{aa:defs:context} for countries).
3) The study simulated at least one scenario with increasing ART coverage,
We included studies published in English anytime before Jan~1, 2020,
that simulated at least one scenario with increasing ART coverage,
possibly alongside other interventions.
The included studies formed Dataset~A,
used to complete objectives \ref{rq:1}~and~\ref{rq:2}.
\par
A subset of Dataset~A formed Dataset~B,
used to complete objective~\ref{rq:3}.
The included studies formed Dataset~A, used to complete objectives \ref{rq:1}~and~\ref{rq:2}.
A subset of Dataset~A formed Dataset~B, used to complete objective~\ref{rq:3}.
Studies in Dataset~B met three additional criteria:
1) examined scale-up of ART coverage alone (versus combination intervention);
2) examined ART intervention for the whole population (versus ART prioritized to subgroups); and
Expand All @@ -95,7 +68,7 @@ \subsection{Data Extraction}
\label{ss:meth:data}
Data extraction used the full text and all available supplementary material.
Data were extracted per-study for objectives \ref{rq:1}~and~\ref{rq:2}, and
per-scenario for objective~\ref{rq:3}.
per-scenario for objective~\ref{rq:3}, possibly including multiple time horizons.
Detailed variables definitions are given in Appendix~\ref{a:defs}.
% ------------------------------------------------------------------------------
\subsubsection{Epidemic Context}
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5 changes: 4 additions & 1 deletion docs/api/tab/criteria.tex
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rather than unique individuals.}
\tnt[4]{SSA was defined based on the countries in
the UN regions of East, South, Central, and West Africa, plus South Sudan
(see Table~\ref{tab:search} for full country list).}
(see Table~\ref{tab:search} for full country list).
Studies were included if the model was parameterized/calirated to reflect
at least one context within SSA.
Only model parameters \& outcomes for SSA contexts were extracted.}
\tnt[5]{Articles reporting HIV incidence reduction and/or
cumulative HIV infections averted among the whole population due to
increased coverage or initiation rate of ART for the whole population.}
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